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Charles Meng

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Charles Q Meng; Liming Ni; Kimberly J Worsencroft; Zhihong Ye; M David Weingarten; Jacob E Simpson; Jason W Skudlarek; Elaine M Marino; Ki-Ling Suen; Charles Kunsch; Amy Souder; Randy B Howard; Cynthia L Sundell; Martin A Wasserman; James A Sikorski
Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.
Charles Q Meng
Atherosclerosis is an inflammatory disorder after all.
Charles Kunsch; Jayraz Luchoomun; Xi-Lin Chen; Geraldine L Dodd; Kanika S Karu; Charles Q Meng; Elaine M Marino; Lynda K Olliff; J Daniel Piper; Fei-Hua Qiu; James A Sikorski; Patricia K Somers; Ki-Ling Suen; Suzanne Thomas; Anne M Whalen; Martin A Wasserman; Cynthia L Sundell
AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

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All Publications

2007: Charles Q Meng; Liming Ni; Kimberly J Worsencroft; Zhihong Ye; M David Weingarten; Jacob E Simpson; Jason W Skudlarek; Elaine M Marino; Ki-Ling Suen; Charles Kunsch; Amy Souder; Randy B Howard; Cynthia L Sundell; Martin A Wasserman; James A Sikorski
Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.
Journal of medicinal chemistry 2007;50(6):1304-15.
2006: Charles Q Meng
Atherosclerosis is an inflammatory disorder after all.
Current topics in medicinal chemistry 2006;6(2):93-102.
2005: Charles Kunsch; Jayraz Luchoomun; Xi-Lin Chen; Geraldine L Dodd; Kanika S Karu; Charles Q Meng; Elaine M Marino; Lynda K Olliff; J Daniel Piper; Fei-Hua Qiu; James A Sikorski; Patricia K Somers; Ki-Ling Suen; Suzanne Thomas; Anne M Whalen; Martin A Wasserman; Cynthia L Sundell
AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.
The Journal of pharmacology and experimental therapeutics 2005;313(2):492-501.
2005: Charles Q Meng
Inflammation in atherosclerosis: new opportunities for drug discovery.
Mini reviews in medicinal chemistry 2005;5(1):33-40.
2004: Charles Q Meng; Patricia K Somers; Lee K Hoong; X Sharon Zheng; Zhihong Ye; Kimberly J Worsencroft; Jacob E Simpson; Martha R Hotema; M David Weingarten; Mathew L MacDOnald; Russell R Hill; Elaine M Marino; Ki-Ling Suen; Jayraz Luchoomun; Charles Kunsch; Laura K Landers; Dimitria Stefanopoulos; Randy B Howard; Cynthia L Sundell; Uday Saxena; Martin A Wasserman; James A Sikorski
Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.
Journal of medicinal chemistry 2004;47(25):6420-32.
2004: Charles Q Meng; X Sharon Zheng; Liming Ni; Zhihong Ye; Jacob E Simpson; Kimberly J Worsencroft; Martha R Hotema; M David Weingarten; Jason W Skudlarek; Joshua M Gilmore; Lee K Hoong; Russell R Hill; Elaine M Marino; Ki-Ling Suen; Charles Kunsch; Martin A Wasserman; James A Sikorski
Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression.
Bioorganic & medicinal chemistry letters 2004;14(6):1513-7.
2003: Cynthia L Sundell; Patricia K Somers; Charles Q Meng; Lee K Hoong; Ki-Ling Suen; Russell R Hill; Laura K Landers; Angela Chapman; Dustie N Butteiger; Moira Jones; David Edwards; Alan Daugherty; Martin A Wasserman; Wayne R Alexander; Russell Medford; Uday Saxena
AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1116-23.
2003: Liming Ni; X Sharon Zheng; Patricia K Somers; Lee K Hoong; Russell R Hill; Elaine M Marino; Ki-Ling Suen; Uday Saxena; Charles Q Meng
Lead discovery of alpha,beta-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression.
Bioorganic & medicinal chemistry letters 2003;13(4):745-8.
2003: Martin A Wasserman; Cynthia L Sundell; Charles Kunsch; David Edwards; Charles Q Meng; Russell Medford
Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.
The American journal of cardiology 2003;91(3A):34A-40A.
2002: Charles Q Meng; Patricia K Somers; Carolyn L Rachita; Lisa A Holt; Lee K Hoong; X Sharon Zheng; Jacob E Simpson; Russell R Hill; Lynda K Olliff; Charles Kunsch; Cynthia L Sundell; Sampath Parthasarathy; Uday Saxena; James A Sikorski; Martin A Wasserman
Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.
Bioorganic & medicinal chemistry letters 2002;12(18):2545-8.
2001: Charles Q Meng; X Sharon Zheng; L A Holt; Lee K Hoong; Patricia K Somers; Russell R Hill; Uday Saxena
Nitrobenzene compounds inhibit expression of VCAM-1.
Bioorganic & medicinal chemistry letters 2001;11(14):1823-7.