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Lucy Mensah

Research Profile

Chemicals & Drugs

Living Beings

Staphylococcus aureus

Genes & Molecular Sequences

Molecular Structure

Concepts & Ideas

Procedures

Microbial Sensitivity Tests

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Publications

TOP 3
Curtis F Crasto; Andrew K Forrest; Tomislav Karoli; Darren R March; Lucy Mensah; Peter J O'Hanlon; Michael R Nairn; Mark D Oldham; Weimin Yue; Martin G Banwell; Christopher J Easton
Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.
Murray J Brown; Paul S Carter; Ashley S Fenwick; Andrew P Fosberry; Dieter W Hamprecht; Martin J Hibbs; Richard L Jarvest; Lucy Mensah; Peter H Milner; Peter J O'Hanlon; Andrew J Pope; Christine M Richardson; Andrew West; David R Witty
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
Richard L Jarvest; John M Berge; Catherine S V Houge-Frydrych; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

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All Publications

2003: Curtis F Crasto; Andrew K Forrest; Tomislav Karoli; Darren R March; Lucy Mensah; Peter J O'Hanlon; Michael R Nairn; Mark D Oldham; Weimin Yue; Martin G Banwell; Christopher J Easton
Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.
Bioorganic & medicinal chemistry 2003;11(13):2687-94.
2002: Murray J Brown; Paul S Carter; Ashley S Fenwick; Andrew P Fosberry; Dieter W Hamprecht; Martin J Hibbs; Richard L Jarvest; Lucy Mensah; Peter H Milner; Peter J O'Hanlon; Andrew J Pope; Christine M Richardson; Andrew West; David R Witty
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
Bioorganic & medicinal chemistry letters 2002;12(21):3171-4.
2001: Richard L Jarvest; John M Berge; Catherine S V Houge-Frydrych; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.
Bioorganic & medicinal chemistry letters 2001;11(18):2499-502.
2001: Richard L Jarvest; John M Berge; Pamela Brown; Dieter W Hamprecht; David J McNair; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope
Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.
Bioorganic & medicinal chemistry letters 2001;11(5):715-8.
2001: Pamela Brown; Drake S Eggleston; R Curtis Haltiwanger; Richard L Jarvest; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope
Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
Bioorganic & medicinal chemistry letters 2001;11(5):711-4.
2000: John M Berge; NJ Broom; Catherine S V Houge-Frydrych; Richard L Jarvest; Lucy Mensah; David J McNair; Peter J O'Hanlon; Andrew J Pope; Stephen Rittenhouse
Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.
The Journal of antibiotics 2000;53(11):1282-92.
2000: Martin G Banwell; Curtis F Crasto; Christopher J Easton; Andrew K Forrest; Tomislav Karoli; Darren R March; Lucy Mensah; Michael R Nairn; Peter J O'Hanlon; Mark D Oldham; Weimin Yue
Analogues of SB-203207 as inhibitors of tRNA synthetases.
Bioorganic & medicinal chemistry letters 2000;10(20):2263-6.
2000: R Macarrón; Lucy Mensah; C Cid; C Carranza; N Benson; Andrew J Pope; E Díez
A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology.
Analytical biochemistry 2000;284(2):183-90.
2000: Andrew K Forrest; Richard L Jarvest; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope; Robert J Sheppard
Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.
Bioorganic & medicinal chemistry letters 2000;10(16):1871-4.
2000: John M Berge; Royston C B Copley; Drake S Eggleston; Dieter W Hamprecht; Richard L Jarvest; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.
Bioorganic & medicinal chemistry letters 2000;10(16):1811-4.
2000: Murray J Brown; Lucy Mensah; Michael Doyle; NJ Broom; N Osbourne; Andrew K Forrest; Christine M Richardson; Peter J O'Hanlon; Andrew J Pope
Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.
Biochemistry 2000;39(20):6003-11.
2000: AL Stefanska; N J Coates; Lucy Mensah; Andrew J Pope; S J Ready; SR Warr
SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties.
The Journal of antibiotics 2000;53(4):345-50.
1999: P Brown; Christine M Richardson; Lucy Mensah; Peter J O'Hanlon; N F Osborne; Andrew J Pope; G Walker
Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.
Bioorganic & medicinal chemistry 1999;7(11):2473-85.
1999: Richard L Jarvest; John M Berge; Catherine S V Houge-Frydrych; C Janson; Lucy Mensah; Peter J O'Hanlon; Andrew J Pope; A Saldanha; Xiayang Qiu
Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.
Bioorganic & medicinal chemistry letters 1999;9(19):2859-62.
1998: Andrew J Pope; KJ Moore; Mary McVey; Lucy Mensah; N Benson; N Osbourne; NJ Broom; Murray J Brown; Peter J O'Hanlon
Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics.
The Journal of biological chemistry 1998;273(48):31691-701.
1998: Andrew J Pope; J Lapointe; Lucy Mensah; N Benson; Murray J Brown; KJ Moore
Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. I: Kinetic mechanism of the substrate activation reaction studied by transient and steady-state techniques.
The Journal of biological chemistry 1998;273(48):31680-90.