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Georges Mer

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TOP 3
Gaofeng Cui; Maria-Victoria Botuyan; Georges Mer
(1)H, (15)N and (13)C resonance assignments for the three LOTUS RNA binding domains of Tudor domain-containing protein TDRD7.
Jiangbo Tang; Erica M Manion; Georges Mer; Niraj M Shanbhag; Maria-Victoria Botuyan; Nam Woo Cho; Gaofeng Cui; Roger A Greenberg
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Christopher J Klein; John Kwok; Sarah J Lincoln; Georges Mer; Tom Bird; Peter J Dyck; Nilüfer Ertekin-Taner; Robert Hjorth; Yanhong Wu; Garth A Nicholson
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.

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All Publications

2013: Gaofeng Cui; Maria-Victoria Botuyan; Georges Mer
(1)H, (15)N and (13)C resonance assignments for the three LOTUS RNA binding domains of Tudor domain-containing protein TDRD7.
Biomolecular NMR assignments 2013;7(1):79-83.
2013: Jiangbo Tang; Erica M Manion; Georges Mer; Niraj M Shanbhag; Maria-Victoria Botuyan; Nam Woo Cho; Gaofeng Cui; Roger A Greenberg
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Nature structural & molecular biology 2013;20(3):317-25.
2013: Christopher J Klein; John Kwok; Sarah J Lincoln; Georges Mer; Tom Bird; Peter J Dyck; Nilüfer Ertekin-Taner; Robert Hjorth; Yanhong Wu; Garth A Nicholson
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Neurology 2013;80(9):824-8.
2012: Pradeep L Ramachandran; Georges Mer; Barbara A Owen; Elena A Atanasova; H Robert Bergen; Theodore A Craig; Gaofeng Cui; Rajiv Kumar
The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
The Journal of biological chemistry 2012;287(47):39439-48.
2012: Namit Singh; James R Thompson; Timothy D Wiltshire; Michael B Yaffe; Harihar Basnet; Maria-Victoria Botuyan; Fergus J Couch; Annie Héroux; Duaa H Mohammad; Michael G Rosenfeld; Georges Mer
Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14381-6.
2012: Gaofeng Cui; Satoshi Kaneko; Donghwa Kim; Joseph Lee; Aimee I Badeaux; Mark T Bedford; Maria-Victoria Botuyan; Jin Q Cheng; Sungman Park; James R Thompson; Fei Yan; Zengqiang Yuan; Georges Mer
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nature structural & molecular biology 2012;19(9):916-24.
2012: Ahmed Fazly; Bruce F Horazdovsky; Qi Hu; Qing Li; Georges Mer; Zhiguo Zhang
Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers.
The Journal of biological chemistry 2012;287(14):10753-60.
2012: Dan SU; James R Thompson; Zhiguo Zhang; Maria-Victoria Botuyan; Gaofeng Cui; Brian A Davies; Ahmed Fazly; Qi Hu; Qing Li; Georges Mer
Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature 2012;483(7387):104-7.
2011: Christopher J Klein; Maria-Victoria Botuyan; Yanhong Wu; Christopher J Ward; Garth A Nicholson; Simon Hammans; Kaori Hojo; Hiromitch Yamanishi; Adam R Karpf; Douglas C Wallace; Mariella Simon; Cecilie Lander; Lisa A Boardman; Julie M Cunningham; Glenn Smith; William J Litchy; Benjamin Boes; Elizabeth J Atkinson; Sumit Middha; P James B Dyck; Joseph E Parisi; Georges Mer; David I Smith; Peter J Dyck
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Nature genetics 2011;43(6):595-600.
2011: Dan SU; Qi Hu; Hui Zhou; James R Thompson; Rui-Ming Xu; Zhiguo Zhang; Georges Mer
Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex.
The Journal of biological chemistry 2011;286(18):15625-9.
2010: Gaofeng Cui; Robert C Benirschke; Han-Fang Tuan; Nenad Juranić; Slobodan Macura; Maria-Victoria Botuyan; Georges Mer
Structural basis of ubiquitin recognition by translesion synthesis DNA polymerase ι.
Biochemistry 2010;49(47):10198-207.
2010: Robert C Benirschke; James R Thompson; Yves Nominé; Emeric Wasielewski; Nenad Juranić; Slobodan Macura; Shigetsugu Hatakeyama; Keiichi I Nakayama; Maria-Victoria Botuyan; Georges Mer
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.
Structure (London, England : 1993) 2010;18(8):955-65.
2009: Gaofeng Cui; Maria-Victoria Botuyan; Georges Mer
Preparation of recombinant peptides with site- and degree-specific lysine (13)C-methylation.
Biochemistry 2009;48(18):3798-800.
2008: CHAO XU; Gaofeng Cui; Maria-Victoria Botuyan; Georges Mer
Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S.
Structure (London, England : 1993) 2008;16(11):1740-50.
2008: Yves Nominé; Maria-Victoria Botuyan; Zeljko Bajzer; Whyte G Owen; Ariel J Caride; Emeric Wasielewski; Georges Mer
Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.
Biochemistry 2008;47(37):9866-79.
2008: CHAO XU; Liming Wu; Gaofeng Cui; Maria-Victoria Botuyan; Junjie Chen; Georges Mer
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
Journal of molecular biology 2008;381(2):361-72.
2008: Sungjo Park; Bernard B C Lim; Carmen Perez-Terzic; Georges Mer; Andre Terzic
Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity.
Journal of proteome research 2008;7(4):1721-8.
2008: Joseph Lee; James R Thompson; Maria-Victoria Botuyan; Georges Mer
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nature structural & molecular biology 2008;15(1):109-11.
2007: Jamie L Wood; Namit Singh; Georges Mer; Junjie Chen
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
The Journal of biological chemistry 2007;282(48):35416-23.
2006: Maria-Victoria Botuyan; Joseph Lee; Irene M Ward; Ja-Eun Kim; James R Thompson; Junjie Chen; Georges Mer
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Cell 2006;127(7):1361-73.
2006: Irene M Ward; Ja-Eun Kim; Kay Minn; Claudia C S Chini; Georges Mer; Junjie Chen
The tandem BRCT domain of 53BP1 is not required for its repair function.
The Journal of biological chemistry 2006;281(50):38472-7.
2006: Fan Gao; Georges Mer; Marco Tonelli; Scott B Hansen; Thomas P Burghardt; Palmer Taylor; Steven M Sine
Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop.
Molecular pharmacology 2006;70(4):1230-5.
2004: Maria-Victoria Botuyan; Yves Nominé; Xiaochun Yu; Nenad Juranic; Slobodan Macura; Junjie Chen; Georges Mer
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.
Structure (London, England : 1993) 2004;12(7):1137-46.
2003: Xiaochun Yu; Claudia C S Chini; Miao He; Georges Mer; Junjie Chen
The BRCT domain is a phospho-protein binding domain.
Science (New York, N.Y.) 2003;302(5645):639-42.
2001: Maria-Victoria Botuyan; Georges Mer; Gwan-Su Yi; Christopher M Koth; D A Case; Aled M Edwards; Walter J Chazin; Cheryl H Arrowsmith
Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.
Journal of molecular biology 2001;312(1):177-86.
2000: Georges Mer; Alexey Bochkarev; R Gupta; Elena Bochkareva; Lori Frappier; C J Ingles; Aled M Edwards; Walter J Chazin
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.
Cell 2000;103(3):449-56.
2000: Georges Mer; Aled M Edwards; Walter J Chazin
1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32 kDa subunit of human replication protein A.
Journal of biomolecular NMR 2000;17(2):179-80.
2000: Georges Mer; Alexey Bochkarev; Walter J Chazin; Aled M Edwards
Three-dimensional structure and function of replication protein A.
Cold Spring Harbor symposia on quantitative biology 2000;65():193-200.
1999: Maria-Victoria Botuyan; Christopher M Koth; Georges Mer; Avijit Chakrabartty; Joan Weliky Conaway; Ronald C Conaway; Aled M Edwards; Cheryl H Arrowsmith; Walter J Chazin
Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9033-8.