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Marc Mercken

Research Profile

Chemicals & Drugs

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Francois Bischoff; Herman Borghys; Michel De Cleyn; Didier Berthelot; Gregor Macdonald; Chantal Masungi; Marc Mercken; Garrett Minne; Daniel Oehlrich; Serge Pieters; Michel Surkyn; Andrés A Trabanco; Gary Tresadern; Sven Van Brandt; Ingrid Velter; Mirko Zaja; Harrie J M Gijsen
Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.
Lujia Zhou; Kris Gevaert; Wim Annaert; Soraia Barão; Katrijn Bockstael; Marianne Borgers; Kris Gevaer; Harry Gijsen; Mathias Laga; Marc Mercken; Diederik Moechars; Bart De Strooper
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
Harrie J M Gijsen; Marc Mercken
γ-Secretase Modulators: Can We Combine Potency with Safety?

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All Publications

2012: Francois Bischoff; Herman Borghys; Michel De Cleyn; Didier Berthelot; Gregor Macdonald; Chantal Masungi; Marc Mercken; Garrett Minne; Daniel Oehlrich; Serge Pieters; Michel Surkyn; Andrés A Trabanco; Gary Tresadern; Sven Van Brandt; Ingrid Velter; Mirko Zaja; Harrie J M Gijsen
Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.
Journal of medicinal chemistry 2012;55(21):9089-106.
2012: Lujia Zhou; Kris Gevaert; Wim Annaert; Soraia Barão; Katrijn Bockstael; Marianne Borgers; Kris Gevaer; Harry Gijsen; Mathias Laga; Marc Mercken; Diederik Moechars; Bart De Strooper
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
The Journal of biological chemistry 2012;287(31):25927-40.
2012: Harrie J M Gijsen; Marc Mercken
γ-Secretase Modulators: Can We Combine Potency with Safety?
International journal of Alzheimer's disease 2012;2012():295207.
2012: Herman Borghys; Ellen Clessens; Willy Cools; Filip De Ridder; Lieve Dillen; Harrie Gijsen; Roel Straetemans; marianne tuefferd; Bianca Van Broeck; Petra Vinken; Marc Mercken
A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators.
Journal of Alzheimer's disease : JAD 2012;28(4):809-22.
2011: Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercken; Koen Van Laere; Philip Van Damme; David Demedts; Fred Van Leuven; Kristel Sleegers; Kerensa Broersen; Christine Van Broeckhoven; Rik Vandenberghe; Bart De Strooper
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
EMBO molecular medicine 2011;3(5):291-302.
2008: Bert Brône; Pieter J Peeters; Roger Marrannes; Marc Mercken; Ronny Nuydens; Theo Meert; Harrie J M Gijsen
Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor.
Toxicology and applied pharmacology 2008;231(2):150-6.
2007: Bert Brône; Dieder Moechars; Roger Marrannes; Marc Mercken; Theo F Meert
P2X currents in peritoneal macrophages of wild type and P2X4 -/- mice.
Immunology letters 2007;113(2):83-9.
2007: Ellen W Baxter; Kelly A Conway; Ludo Kennis; François Bischoff; Marc Mercken; Hans L De Winter; Charles H Reynolds; Brett A Tounge; Chi Luo; Malcolm K Scott; Yifang Huang; Mirielle Braeken; Serge M A Pieters; Didier J C Berthelot; Stefan Masure; Wouter D Bruinzeel; Alfonzo D Jordan; Michael H Parker; Robert E Boyd; Junya Qu; Richard S Alexander; Douglas E Brenneman; Allen B Reitz
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Journal of medicinal chemistry 2007;50(18):4261-4.
2006: Rime MADANI; Raphael Poirier; David P Wolfer; Hans Welzl; Peter Groscurth; Hans-Peter Lipp; Bao Lu; Mohammed El Mouedden; Marc Mercken; Roger M Nitsch; M Hasan Mohajeri
Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo.
Journal of neuroscience research 2006;84(8):1871-8.
2006: Kangning Liu; Ingrid Solano; D M A Mann; Cynthia A Lemere; Marc Mercken; John Q Trojanowski; Virginia M-Y Lee
Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
Acta neuropathologica 2006;112(2):163-74.
2006: Mohammed El Mouedden; Marc Vandermeeren; Theo F Meert; Marc Mercken
Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.
Current pharmaceutical design 2006;12(6):671-6.
2005: W Haung Yu; Ana Maria Cuervo; Asok Kumar; Corrinne M Peterhoff; Stephen D Schmidt; Ju-Hyun Lee; Panaiyur S Mohan; Marc Mercken; Mark Farmery; Lars O Tjernberg; Ying Jiang; karen duff; Yasuo Uchiyama; Jan Näslund; Paul Mathews; Anne M Cataldo; Ralph A. Nixon
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology 2005;171(1):87-98.
2005: Mohammed El Mouedden; Marc Haseldonckx; Claire Mackie; Theo F Meert; Marc Mercken
Method for the determination of the levels of beta-amyloid peptide in the CSF sampled from freely moving rats.
Journal of pharmacological and toxicological methods 2005;52(2):229-33.
2005: Mohammed El Mouedden; Marc Vandermeeren; Theo F Meert; Marc Mercken
Development of a specific ELISA for the quantitative study of amino-terminally truncated beta-amyloid peptides.
Journal of neuroscience methods 2005;145(1-2):97-105.
2004: Anne M Cataldo; Suzana Petanceska; Nicole B Terio; Corrinne M Peterhoff; Robert Durham; Marc Mercken; Pankaj D Mehta; Joseph Buxbaum; Vahram Haroutunian; Ralph A. Nixon
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.
Neurobiology of aging 2004;25(10):1263-72.
2003: Mark Burns; Kate Gaynor; Vicki Olm; Marc Mercken; John LaFrancois; Lili Wang; Paul Mathews; Wendy Noble; Yasuji Matsuoka; karen duff
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5645-9.
2003: Melanie Meyer-Luehmann; Martina Stalder; Martin C Herzig; Stephan A Kaeser; Esther Kohler; Michelle Pfeifer; Sonia Boncristiano; Paul Mathews; Marc Mercken; Dorothee Abramowski; Matthias Staufenbiel; Mathias Jucker
Extracellular amyloid formation and associated pathology in neural grafts.
Nature neuroscience 2003;6(4):370-7.
2003: Andrew L Darrow; Kelly A Conway; Anil Vaidya; Daniel Rosenthal; Mary Jo Wildey; Lisa Minor; Zina Itkin; Yan Kong; Jennifer Piesvaux; Jenson Qi; Marc Mercken; Patricia Andrade-Gordon; Carlos R Plata-Salamán; Sergey E Ilyin
Virus-based expression systems facilitate rapid target in vivo functionality validation and high-throughput screening.
Journal of biomolecular screening 2003;8(1):65-71.
2003: Stefan Pype; Dieder Moechars; Lieve Dillen; Marc Mercken
Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein.
Journal of neurochemistry 2003;84(3):602-9.
2002: Paul Mathews; Ying Jiang; Stephen D Schmidt; Olivera M Grbovic; Marc Mercken; Ralph A. Nixon
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments.
The Journal of biological chemistry 2002;277(39):36415-24.
2002: Omar Nyabi; Stefan Pype; Marc Mercken; An Herreman; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Willem ANNAERT; Bart De Strooper
No endogenous A beta production in presenilin-deficient fibroblasts.
Nature cell biology 2002;4(7):E164; author reply E165-6.
2002: Ilse Dewachter; Delphine Reversé; Nathalie Caluwaerts; Laurence Ris; Cuno Kuipéri; Chris Van den Haute; Kurt Spittaels; Lieve Umans; Lutgarde Serneels; Els Thiry; Dieder Moechars; Marc Mercken; Emile Godaux; Fred Van Leuven
Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3445-53.
2002: Richard Rozmahel; Jean Huang; Fusheng Chen; Yan Liang; Van Nguyen; Masaki Ikeda; Georges Levesque; Gang G. Yu; M Nishimura; Paul Mathews; Stephen D Schmidt; Marc Mercken; Catherine Bergeron; David Westaway; Peter St George-Hyslop
Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Neurobiology of aging 2002;23(2):187-94.
2002: Paul Mathews; Carolyn B Guerra; Ying Jiang; Olivera M Grbovic; Benjamin H Kao; Stephen D Schmidt; Ravi Dinakar; Marc Mercken; Annette Hille-Rehfeld; Jack Rohrer; Pankaj Mehta; Anne M Cataldo; Ralph A. Nixon
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.
The Journal of biological chemistry 2002;277(7):5299-307.
2002: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; Dick Terwel; K Vandezande; Reena Lasrado; K Bruynseels; Michael C Irizarry; Marleen Verhoye; Johan Van Lint; Jackie R Vandenheede; D Ashton; Marc Mercken; R Loos; Bradley T Hyman; Annemie Van der Linden; Hugo Geerts; Fred Van Leuven
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.
Neuroscience 2002;113(4):797-808.
2001: Marc Vandermeeren; M Geraerts; Stefan Pype; Lieve Dillen; C Van Hove; Marc Mercken
The functional gamma-secretase inhibitor prevents production of amyloid beta 1-34 in human and murine cell lines.
Neuroscience letters 2001;315(3):145-8.
2001: Lorenzo M Refolo; Miguel Pappolla; John LaFrancois; Brian Malester; Stephen D Schmidt; T Thomas-Bryant; Stephen G Tint; Runsheng Wang; Marc Mercken; Suzana Petanceska; karen duff
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2001;8(5):890-9.
2000: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; Hugo Geerts; Marc Mercken; K Bruynseels; Reena Lasrado; K Vandezande; I Laenen; T Boon; Johan Van Lint; Jackie R Vandenheede; Dieder Moechars; R Loos; Fred Van Leuven
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.
The Journal of biological chemistry 2000;275(52):41340-9.
2000: Christopher Janus; J Pearson; JoAnne McLaurin; Paul Mathews; Y Jiang; Stephen D Schmidt; M Azhar Chishti; Patrick Horne; D Heslin; J French; Howard T J Mount; Ralph A. Nixon; Marc Mercken; Catherine Bergeron; Paul E Fraser; Peter St George-Hyslop; David Westaway
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Nature 2000;408(6815):979-82.
2000: Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; R Kleinert; Rong Wang; Marc Mercken; Bart De Strooper; hugo vanderstichele; Ann Löfgren; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; P M Kroisel; Christine Van Broeckhoven
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Human molecular genetics 2000;9(18):2589-98.
2000: Jo Van Dorpe; Liesbet Smeijers; Ilse Dewachter; Dieter Nuyens; Kurt Spittaels; Chris Van den Haute; Marc Mercken; Dieder Moechars; I Laenen; Cuno Kuiperi; K Bruynseels; Ina C. Tesseur; R Loos; hugo vanderstichele; F Checler; Raf Sciot; Fred Van Leuven
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.
The American journal of pathology 2000;157(4):1283-98.
1999: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; K Bruynseels; K Vandezande; I Laenen; Hugo Geerts; Marc Mercken; Raf Sciot; Alfons Van Lommel; R Loos; Fred Van Leuven
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein.
The American journal of pathology 1999;155(6):2153-65.
1997: Emil Adamec; Marc Mercken; ML Beermann; M Didier; Ralph A. Nixon
Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau.
Brain research 1997;757(1):93-101.