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Dan Mercola

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

Living Beings

Mouse

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Zhenyu Jia; James A Koziol; Waldemar Lernhardt; Michael McClelland; Christine McLaren; Yipeng Wang; Xiao-Qin Xia; Kai Ye; Yingyan Yu; Yuanjie Hu; Dan Mercola
A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies.
Rebecca Pio; Veronique T Baron; Zhenyu Jia; Dan Mercola
Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.
Xin Chen; Zhenyu Jia; Michael McClelland; Farahnaz Rahmatpanah; Anne Sawyers; Shizhong Xu; Dan Mercola
An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account.

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All Publications

2013: Zhenyu Jia; James A Koziol; Waldemar Lernhardt; Michael McClelland; Christine McLaren; Yipeng Wang; Xiao-Qin Xia; Kai Ye; Yingyan Yu; Yuanjie Hu; Dan Mercola
A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies.
Anti-cancer agents in medicinal chemistry 2013;13(2):203-11.
2013: Rebecca Pio; Veronique T Baron; Zhenyu Jia; Dan Mercola
Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.
PloS one 2013;8(1):e54096.
2012: Xin Chen; Zhenyu Jia; Michael McClelland; Farahnaz Rahmatpanah; Anne Sawyers; Shizhong Xu; Dan Mercola
An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account.
PloS one 2012;7(9):e45178.
2012: Zhenyu Jia; Waldemar Lernhardt; Michael McClelland; Farahnaz Rahmatpanah; Anne Sawyers; Manuel Sutton; Yipeng Wang; Xiao-Qin Xia; Xin Chen; Dan Mercola
Expression changes in the stroma of prostate cancer predict subsequent relapse.
PloS one 2012;7(8):e41371.
2011: Zhenyu Jia; Yipeng Wang; Anne Sawyers; Huazhen Yao; Farahnaz Rahmatpanah; Xiao-Qin Xia; Qiang Xu; Rebecca Pio; Tolga Turan; James A Koziol; Steve Goodison; Philip Carpenter; Jessica Wang-Rodriguez; Anne Simoneau; Frank Meyskens; Manuel Sutton; Waldemar Lernhardt; Thomas Beach; Joseph Monforte; Michael McClelland; Dan Mercola
Diagnosis of prostate cancer using differentially expressed genes in stroma.
Cancer research 2011;71(7):2476-87.
2010: Yipeng Wang; Xiao-Qin Xia; Zhenyu Jia; Anne Sawyers; Huazhen Yao; Jessica Wang-Rodriquez; Dan Mercola; Michael McClelland
In silico estimates of tissue components in surgical samples based on expression profiling data.
Cancer research 2010;70(16):6448-55.
2009: Jianxiu Yu; Sharon S Zhang; Kan Saito; Scott Williams; Yutaka Arimura; Yuliang Ma; Yuehai Ke; Véronique Baron; Dan Mercola; Gen-Sheng Feng; Eileen D Adamson; Tomas Mustelin
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
The EMBO journal 2009;28(1):21-33.
2008: Maryla Krajewska; Shinichi Kitada; Jane N Winter; Daina Variakojis; Alan Lichtenstein; Dayong Zhai; Michael Cuddy; Xianshu Huang; Frederic Luciano; Cheryl H Baker; Hoguen Kim; Eunah Shin; Susan Kennedy; Allen H Olson; Andrzej Badzio; Jacek Jassem; Ivo Meinhold-Heerlein; Michael J Duffy; Aaron D Schimmer; Ming Tsao; Ewan Brown; Anne Sawyers; Michael Andreeff; Dan Mercola; Stan Krajewski; John C Reed
Bcl-B expression in human epithelial and nonepithelial malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(10):3011-21.
2007: Maryla Krajewska; Allen H Olson; Dan Mercola; John C Reed; Stan Krajewski
Claudin-1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate.
The Prostate 2007;67(9):907-10.
2007: J Yu; Véronique Baron; Dan Mercola; Tomas Mustelin; Eileen D Adamson
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells.
Cell death and differentiation 2007;14(3):436-46.
2006: Véronique Baron; Eileen D Adamson; Antonella Calogero; Giuseppe Ragona; Dan Mercola
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.
Cancer gene therapy 2006;13(2):115-24.
2006: Jean Spence; Brendan Duggan; Colleen Eckhardt; Michael McClelland; Dan Mercola
Messenger RNAs under differential translational control in Ki-ras-transformed cells.
Molecular cancer research : MCR 2006;4(1):47-60.
2005: Yipeng Wang; Jun Hayakawa; Fred Long; Qiuju Yu; Ann H Cho; Gaelle Rondeau; John Welsh; Shalu Mittal; Ian De Belle; Eileen D Adamson; Michael McClelland; Dan Mercola
"Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells.
Annals of the New York Academy of Sciences 2005;1058():162-85.
2005: Yipeng Wang; Qiuju Yu; Ann H Cho; Gaelle Rondeau; John Welsh; Eileen D Adamson; Dan Mercola; Michael McClelland
Survey of differentially methylated promoters in prostate cancer cell lines.
Neoplasia (New York, N.Y.) 2005;7(8):748-60.
2005: Jun Tang; Xiaomei Qi; Dan Mercola; Jiahuai Han; Guan Chen
Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
The Journal of biological chemistry 2005;280(25):23910-7.
2005: Anja Krones-Herzig; Shalu Mittal; Kelly Yule; Hongyan Liang; Chris English; Rafael Urcis; Tarun Soni; Eileen D Adamson; Dan Mercola
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.
Cancer research 2005;65(12):5133-43.
2004: Jun Hayakawa; Shalu Mittal; Yipeng Wang; Kemal Sami Korkmaz; Eileen D Adamson; Christopher English; Masahide Ohmichi; Masahide Omichi; Michael McClelland; Dan Mercola
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress.
Molecular cell 2004;16(4):521-35.
2004: Dan Mercola; John Welsh
From mRNA to tumor suppressor.
Nature genetics 2004;36(9):937-8.
2004: Robert O Stuart; William Wachsman; Charles C Berry; Jessica Wang-Rodriguez; Linda Wasserman; Igor Klacansky; Daniel R Masys; Karen C Arden; Steve Goodison; Michael McClelland; Yipeng Wang; Anne Sawyers; Iveta Kalcheva; David Tarin; Dan Mercola
In silico dissection of cell-type-associated patterns of gene expression in prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):615-20.
2003: Véronique Baron; Stephan Duss; Johng S Rhim; Dan Mercola
Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice.
Annals of the New York Academy of Sciences 2003;1002():197-216.
2003: Eileen D Adamson; Ian De Belle; Shalu Mittal; Yipeng Wang; Jun Hayakawa; Kemal Sami Korkmaz; David O'Hagan; Michael McClelland; Dan Mercola
Egr1 signaling in prostate cancer.
Cancer biology & therapy 2003;2(6):617-22.
2003: Véronique Baron; Giorgia De Gregorio; Anja Krones-Herzig; Thierry Virolle; Antonella Calogero; Rafael Urcis; Dan Mercola
Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo.
Oncogene 2003;22(27):4194-204.
2003: Jun Hayakawa; Chantal Depatie; Masahide Ohmichi; Dan Mercola
The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair.
The Journal of biological chemistry 2003;278(23):20582-92.
2003: Ian De Belle; Jie-Xin Wu; Sabina Sperandio; Dan Mercola; Eileen D Adamson
In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1.
The Journal of biological chemistry 2003;278(16):14306-12.
2003: Thierry Virolle; Anja Krones-Herzig; Véronique Baron; Giorgia De Gregorio; Eileen D Adamson; Dan Mercola
Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes.
The Journal of biological chemistry 2003;278(14):11802-10.
2003: Anja Krones-Herzig; Eileen D Adamson; Dan Mercola
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3233-8.
2003: Yong-Min Yang; Frédéric Bost; Wilfried Charbono; Nicholas Dean; Robert McKay; Johng S Rhim; Chantal Depatie; Dan Mercola
C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):391-401.
2002: Eileen D Adamson; Dan Mercola
Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2002;23(2):93-102.
2001: Thierry Virolle; Eileen D Adamson; Véronique Baron; Diana Birle; Dan Mercola; Tomas Mustelin; Ian De Belle
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling.
Nature cell biology 2001;3(12):1124-8.
2001: Antonella Calogero; Antonietta Arcella; Giorgia De Gregorio; Antonio Porcellini; Dan Mercola; C Liu; Vincenza Lombari; Massimo Zani; G Giannini; Franco Maria Gagliardi; R Caruso; Alberto Gulino; Luigi Frati; Giuseppe Ragona
The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2788-96.
2001: Olga Potapova; S Basu; Dan Mercola; Nikki J Holbrook
Protective role for c-Jun in the cellular response to DNA damage.
The Journal of biological chemistry 2001;276(30):28546-53.
2001: E Parra; Tomas Mustelin; M Dohlsten; Dan Mercola
Identification of a CD28 response element in the CD40 ligand promoter.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2437-43.
2001: Ruth A Gjerset; Ali Haghighi; S Lebedeva; Dan Mercola
Gene therapy approaches to sensitization of human prostate carcinoma to cisplatin by adenoviral expression of p53 and by antisense jun kinase oligonucleotide methods.
Methods in molecular biology (Clifton, N.J.) 2001;175():495-520.
2000: Olga Potapova; Myriam Gorospe; Frédéric Bost; Nicholas Dean; William A Gaarde; Dan Mercola; Nikki J Holbrook
c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.
The Journal of biological chemistry 2000;275(32):24767-75.
2000: C Liu; J Yao; Dan Mercola; Eileen D Adamson
The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251.
The Journal of biological chemistry 2000;275(27):20315-23.
2000: Ian De Belle; Dan Mercola; Eileen D Adamson
Method for cloning in vivo targets of the Egr-1 transcription factor.
BioTechniques 2000;29(1):162-9.
2000: Ruth A Gjerset; Dan Mercola
Sensitization of tumors to chemotherapy through gene therapy.
Advances in experimental medicine and biology 2000;465():273-91.
2000: Frédéric Bost; Robert McKay; Nicholas Dean; Olga Potapova; Dan Mercola
Antisense methods for discrimination of phenotypic properties of closely related gene products: Jun kinase family.
Methods in enzymology 2000;314():342-62.
1999: A Agadir; G q Chen; Frédéric Bost; Y Li; Dan Mercola; X Zhang
Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines.
The Journal of biological chemistry 1999;274(42):29779-85.
1999: RE Sobol; Daniel L Shawler; C Carson; C Van Beveren; Dan Mercola; Habib Fakhrai; M A Garrett; R Barone; P Goldfarb; Richard Bartholomew; SW Brostoff; Dennis J Carlo; I Royston; DP Gold
Interleukin 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: a Phase I study.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2359-65.
1999: Ruth A Gjerset; S Lebedeva; Ali Haghighi; S T Turla; Dan Mercola
Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(8):545-54.
1999: Ian De Belle; Ruo-Pan Huang; Y Fan; C Liu; Dan Mercola; Eileen D Adamson
p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis.
Oncogene 1999;18(24):3633-42.
1999: Frédéric Bost; Robert McKay; M Bost; Olga Potapova; Nicholas Dean; Dan Mercola
The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells.
Molecular and cellular biology 1999;19(3):1938-49.
1999: C Liu; J Yao; Ian De Belle; Ruo-Pan Huang; Eileen D Adamson; Dan Mercola
The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1.
The Journal of biological chemistry 1999;274(7):4400-11.
1998: Y Li; Bingzhen Lin; A Agadir; R Liu; Marcia I Dawson; John C Reed; Joseph A Fontana; Frédéric Bost; Peter D Hobbs; Y Zheng; Guo-quan Chen; B Shroot; Dan Mercola; Xiao-kun Zhang
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.
Molecular and cellular biology 1998;18(8):4719-31.
1998: C Liu; V M Rangnekar; Eileen D Adamson; Dan Mercola
Suppression of growth and transformation and induction of apoptosis by EGR-1.
Cancer gene therapy 1998;5(1):3-28.
1997: Frédéric Bost; Robert McKay; Nicholas Dean; Dan Mercola
The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.
The Journal of biological chemistry 1997;272(52):33422-9.
1997: Ruo-Pan Huang; Y Fan; Z Ni; Dan Mercola; Eileen D Adamson
Reciprocal modulation between Sp1 and Egr-1.
Journal of cellular biochemistry 1997;66(4):489-99.
1997: Ruo-Pan Huang; Y Fan; Ian De Belle; C Niemeyer; M M Gottardis; Dan Mercola; Eileen D Adamson
Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation.
International journal of cancer. Journal international du cancer 1997;72(1):102-9.
1997: Olga Potapova; Ali Haghighi; Frédéric Bost; C Liu; Michael J Birrer; Ruth A Gjerset; Dan Mercola
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.
The Journal of biological chemistry 1997;272(22):14041-4.
1997: Daniel L Shawler; Habib Fakhrai; C Van Beveren; Dan Mercola; DP Gold; Richard Bartholomew; I Royston; RE Sobol
Gene therapy approaches to enhance antitumor immunity.
Advances in pharmacology (San Diego, Calif.) 1997;40():309-37.
1996: Antonella Calogero; L Cuomo; M D'Onofrio; U de Grazia; P Spinsanti; Dan Mercola; Alberto Faggioni; Luigi Frati; Eileen D Adamson; Giuseppe Ragona
Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines.
Oncogene 1996;13(10):2105-12.
1996: C Liu; Eileen D Adamson; Dan Mercola
Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11831-6.
1996: Olga Potapova; Habib Fakhrai; Dan Mercola
Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism.
International journal of cancer. Journal international du cancer 1996;66(5):669-77.
1996: Habib Fakhrai; Oliver Dorigo; Daniel L Shawler; H Lin; Dan Mercola; K L Black; I Royston; R E Sobol
Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2909-14.
1996: Olga Potapova; Habib Fakhrai; S Baird; Dan Mercola
Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells.
Cancer research 1996;56(2):280-6.
1996: C Liu; Antonella Calogero; Giuseppe Ragona; Eileen D Adamson; Dan Mercola
EGR-1, the reluctant suppression factor: EGR-1 is known to function in the regulation of growth, differentiation, and also has significant tumor suppressor activity and a mechanism involving the induction of TGF-beta1 is postulated to account for this suppressor activity.
Critical reviews in oncogenesis 1996;7(1-2):101-25.
1995: Ruth A Gjerset; S T Turla; RE Sobol; J J Scalise; Dan Mercola; H Collins; P J Hopkins
Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.
Molecular carcinogenesis 1995;14(4):275-85.
1995: Ruo-Pan Huang; C Liu; Y Fan; Dan Mercola; Eileen D Adamson
Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.
Cancer research 1995;55(21):5054-62.
1995: Ruth A Gjerset; Habib Fakhrai; Daniel L Shawler; S Turla; Oliver Dorigo; A Grover-Bardwick; Dan Mercola; S F Wen; H Collins; H Lin
Characterization of a new human glioblastoma cell line that expresses mutant p53 and lacks activation of the PDGF pathway.
In vitro cellular & developmental biology. Animal 1995;31(3):207-14.
1995: Dan Mercola; J S Cohen
Antisense approaches to cancer gene therapy.
Cancer gene therapy 1995;2(1):47-59.
1995: RE Sobol; I Royston; Habib Fakhrai; Daniel L Shawler; C Carson; Oliver Dorigo; Ruth A Gjerset; DP Gold; J Koziol; Dan Mercola
Injection of colon carcinoma patients with autologous irradiated tumor cells and fibroblasts genetically modified to secrete interleukin-2 (IL-2): a phase I study.
Human gene therapy 1995;6(2):195-204.
1994: A Grover-Bardwick; E Adamson; Dan Mercola
Transformation-specific pattern of phosphorylation of c-Jun, Jun-B, Jun-D and Egr-1 in v-sis transformed cells.
Carcinogenesis 1994;15(8):1667-74.
1994: Ruo-Pan Huang; T Darland; D Okamura; Dan Mercola; Eileen D Adamson
Suppression of v-sis-dependent transformation by the transcription factor, Egr-1.
Oncogene 1994;9(5):1367-77.
1992: Dan Mercola; Philip M Carpenter; A Grover-Bardwick; M Mercola
Rapid, complete and reversible transformation by v-sis precedes irreversible transformation.
Oncogene 1992;7(9):1793-803.
1992: T Smeal; B Binetruy; Dan Mercola; A Grover-Bardwick; Gisela Heidecker; U R Rapp; Michael Karin
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.
Molecular and cellular biology 1992;12(8):3507-13.
1991: T Smeal; B Binetruy; Dan Mercola; Michael J Birrer; Michael Karin
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Nature 1991;354(6353):494-6.
1991: Giuseppe Ragona; S A Edwards; Dan Mercola; Eileen D Adamson; Antonella Calogero
The transcriptional factor Egr-1 is synthesized by baculovirus-infected insect cells in an active, DNA-binding form.
DNA and cell biology 1991;10(1):61-6.
1991: Philip M Carpenter; M Mercola; Dan Mercola
Reversible transformation by v-sis: a model cell line for analysis of transformation by antisense methods.
Antisense research and development 1991;1(3):289-95.
1990: J X Wu; Philip M Carpenter; C Gresens; R Keh; H Niman; J W Morris; Dan Mercola
The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas.
Oncogene 1990;5(7):989-1000.
1988: Dan Mercola; J Westwick; A Y Rundell; Eileen D Adamson; S A Edwards
Analysis of a transformed cell line using antisense c-fos RNA.
Gene 1988;72(1-2):253-65.
1987: Dan Mercola; A Rundell; J Westwick; S A Edwards
Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line.
Biochemical and biophysical research communications 1987;147(1):288-94.
1987: Dan Mercola
The proto-oncogene c-fos encodes a potential regulatory site that is disrupted by viral transduction.
Journal of theoretical biology 1987;126(2):243-6.