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Jere Meredith

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Alzheimer's Disease

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Molecular Structure

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Publications

TOP 3
Samuel W Gerritz; Andrew C Good; Lawrence G Iben; Kimberley A Lentz; John E Macor; Jere E Meredith; William Metzler; Jodi K Muckelbauer; Ramesh Padmanabha; Michael A Poss; Shuhao Shi; Michael J Sofia; Andrew J Tebben; Charles F Albright; Catherine R Burton; Daniel M Camac; Lynda S Cook; Jeremy H Toyn; Weixu Zhai; Shirong Zhu; Lorin A Thompson
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
Donna M Barten; Gregory W Cadelina; Lynn B DeCarr; Patrizia Fanara; Chancy Fessler; Gemma Gray; Amanda Hanna; Nina Hoque; Kristofor H Husted; Christopher Janus; Soong-Hoon Kim; Francis Y Lee; Victoria Liu; Jere E Meredith; Richard E Olson; Craig T Polson; Joan Protassio; Timothy Riff; Sethu Sankaranarayanan; Holly Turner; Gregory D Vite; P Y Anne Wong; Ling Yang; Cathy Andorfer; Charles F Albright
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

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All Publications

2012: Samuel W Gerritz; Andrew C Good; Lawrence G Iben; Kimberley A Lentz; John E Macor; Jere E Meredith; William Metzler; Jodi K Muckelbauer; Ramesh Padmanabha; Michael A Poss; Shuhao Shi; Michael J Sofia; Andrew J Tebben; Charles F Albright; Catherine R Burton; Daniel M Camac; Lynda S Cook; Jeremy H Toyn; Weixu Zhai; Shirong Zhu; Lorin A Thompson
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
Journal of medicinal chemistry 2012;55(21):9208-23.
2012: Donna M Barten; Gregory W Cadelina; Lynn B DeCarr; Patrizia Fanara; Chancy Fessler; Gemma Gray; Amanda Hanna; Nina Hoque; Kristofor H Husted; Christopher Janus; Soong-Hoon Kim; Francis Y Lee; Victoria Liu; Jere E Meredith; Richard E Olson; Craig T Polson; Joan Protassio; Timothy Riff; Sethu Sankaranarayanan; Holly Turner; Gregory D Vite; P Y Anne Wong; Ling Yang; Cathy Andorfer; Charles F Albright
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(21):7137-45.
2011: Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(22):6909-15.
2011: Kenneth M Boy; Joanne J Bronson; Catherine R Burton; Daniel M Camac; Andrew C Good; Jason M Guernon; Kimberley A Lentz; John E Macor; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Jeremy H Toyn; Lorin A Thompson
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
Bioorganic & medicinal chemistry letters 2011;21(22):6916-24.
2011: Donna M Barten; Gregory W Cadelina; Nina Hoque; Lynn B DeCarr; Valerie L Guss; Ling Yang; Sethu Sankaranarayanan; Paul D Wes; Marianne E Flynn; Jere E Meredith; Michael K Ahlijanian; Charles F Albright
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.
Journal of Alzheimer's disease : JAD 2011;24 Suppl 2():127-41.
2011: Lawrence R Marcin; Mendi A Higgins; F Christopher Zusi; Yunhui Zhang; Michael F Dee; Michael F Parker; Jodi K Muckelbauer; Daniel M Camac; Paul E Morin; Vidhyashankar Ramamurthy; Andrew J Tebben; Kimberley A Lentz; James E Grace; Jovita A Marcinkeviciene; Lisa M Kopcho; Catherine R Burton; Donna M Barten; Jeremy H Toyn; Jere E Meredith; Charles F Albright; Joanne J Bronson; John E Macor; Lorin A Thompson
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorganic & medicinal chemistry letters 2011;21(1):537-41.
2010: Jeremy H Toyn; Xu-Alan Lin; Mark W Thompson; Valerie Guss; Jere E Meredith; Sethu Sankaranarayanan; Nestor Barrezueta; John Corradi; Antara Majumdar; Daniel L Small; Melissa Hansard; Thomas Lanthorn; Ryan S Westphal; Charles F Albright
Viable mouse gene ablations that robustly alter brain Aβ levels are rare.
BMC neuroscience 2010;11():143.
2008: Jere E Meredith; Lorin A Thompson; Jeremy H Toyn; Lawrence Marcin; Donna M Barten; Jovita Marcinkeviciene; Lisa Kopcho; Young Kim; Alan Lin; Valerie Guss; Catherine Burton; Lawrence Iben; Craig Polson; Joe Cantone; Michael Ford; Dieter Drexler; Tracey Fiedler; Kimberley A Lentz; James E Grace; Janet Kolb; Jason Corsa; Maria Pierdomenico; Kelli Jones; Richard E Olson; John E Macor; Charles F Albright
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
The Journal of pharmacology and experimental therapeutics 2008;326(2):502-13.
2008: Michael J Ford; Joseph L Cantone; Craig T Polson; Jeremy H Toyn; Jere E Meredith; Dieter M Drexler
Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.
Journal of neuroscience methods 2008;168(2):465-74.
2006: Lorin A Thompson; Ann Y Liauw; Mercy M Ramanjulu; Padmaja Kasireddy-Polam; Stephen E Mercer; Thomas Maduskuie; Marcie Glicksman; Arthur H Roach; Jere E Meredith; Rui-Qin Liu; Andrew P Combs; Jeffrey N Higaki; Barbara Cordell; Dietmar Seiffert; Robert Zaczek; David W Robertson; Richard E Olson
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(9):2357-63.
2006: Donna M Barten; Jere E Meredith; Robert Zaczek; John G Houston; Charles F Albright
Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.
Drugs in R&D 2006;7(2):87-97.
2002: Jere E Meredith; Qian Wang; Thomas J Mitchell; Richard E Olson; Robert Zaczek; Andrew M Stern; Dietmar Seiffert
Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.
Biochemical and biophysical research communications 2002;299(5):744-50.
2002: Yuval Blat; Jere E Meredith; Qian Wang; Jodi D Bradley; Lorin A Thompson; Richard E Olson; Andrew M Stern; Dietmar Seiffert
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.
Biochemical and biophysical research communications 2002;299(4):569-73.
2000: Dietmar Seiffert; Jodi D Bradley; Cynthia M Rominger; David H Rominger; F Yang; Jere E Meredith; Qian Wang; Arthur H Roach; Lorin A Thompson; Susan M Spitz; Jeffrey N Higaki; Shimoga R Prakash; Andrew P Combs; Robert Copeland; Stephen P Arneric; Paul R Hartig; David W Robertson; Barbara Cordell; Andrew M Stern; Richard E Olson; Robert Zaczek
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.
The Journal of biological chemistry 2000;275(44):34086-91.