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Frans Merkus
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Research Profile (preview)
Procedures
Anatomy
Phenomena
Living Beings
Chemicals & Drugs
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Network (preview)
24
Verhoef, Jan
19
Romeijn, Stefan
17
Zuidema, J
12
Hooymans, Piet
6
Lohman, J J H M
6
Marttin, E
6
van den Berg, Mascha
3
Graamans, Kees
3
Merkus, Paul
3
Nagelkerke, Fred
2
Huizing, Egbert
2
Janknegt, R
2
Junginger, Hans
2
Boek, Wilbert
2
Duchateau, Guus
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All Publications
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2007: Merkus Frans W H M; van den Berg Mascha P
Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory.
Drugs in R&D 2007;8(3):133-44.
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2005: in 't Veen Joke P M; van den Berg Mascha P; Romeijn Stefan G; Verhoef J Coos; Merkus Frans W H M
Uptake of fluorescein isothiocyanate-labelled dextran into the CSF after intranasal and intravenous administration to rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;61(1-2):27-31.
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2004: van den Berg Mascha P; Verhoef J Coos; Romeijn Stefan G; Merkus Frans W H M
Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(1):131-5.
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2004: van den Berg Mascha P; Merkus Paul; Romeijn Stefan G; Verhoef J Coos; Merkus Frans W H M
Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study.
Pharmaceutical research 2004;21(5):799-802.
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2003: Van den Berg Mascha P; Merkus Paul; Romeijn Stefan G; Verhoef J Coos; Merkus Frans W H M
Hydroxocobalamin uptake into the cerebrospinal fluid after nasal and intravenous delivery in rats and humans.
Journal of drug targeting 2003;11(6):325-31.
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2003: Merkus Paul; Guchelaar Henk-Jan; Bosch D Andries; Merkus Frans W H M
Direct access of drugs to the human brain after intranasal drug administration?
Neurology 2003;60(10):1669-71.
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2002: van den Berg Mascha P; Romeijn Stefan G; Verhoef J Coos; Merkus Frans W H M
Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity.
Journal of neuroscience methods 2002;116(1):99-107.
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2001: Merkus P; Romeijn S G; Verhoef J C; Merkus F W; Schouwenburg P F
Classification of cilio-inhibiting effects of nasal drugs.
The Laryngoscope 2001;111(4 Pt 1):595-602.
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1999: Thanou M M; Verhoef J C; Romeijn S G; Nagelkerke J F; Merkus F W; Junginger H E
Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea.
International journal of pharmaceutics 1999;185(1):73-82.
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1999: Marttin E; Verhoef J C; Spies F; van der Meulen J; Nagelkerke J F; Koerten H K; Merkus F W
The effect of methylated beta-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium: electron microscopic and confocal laser scanning microscopic visualization studies.
Journal of controlled release : official journal of the Controlled Release Society 1999;57(2):205-13.
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1999: Boek W M; Romeijn S G; Graamans K; Verhoef J C; Merkus F W; Huizing E H
Validation of animal experiments on ciliary function in vitro. II. The influence of absorption enhancers, preservatives and physiologic saline.
Acta oto-laryngologica 1999;119(1):98-101.
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1999: Boek W M; Romeijn S G; Graamans K; Verhoef J C; Merkus F W; Huizing E H
Validation of animal experiments on ciliary function in vitro. I. The influence of substances used clinically.
Acta oto-laryngologica 1999;119(1):93-7.
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1998: Marttin E; Verhoef J C; Merkus F W
Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs.
Journal of drug targeting 1998;6(1):17-36.
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1997: Marttin E; Romeijn S G; Verhoef J C; Merkus F W
Nasal absorption of dihydroergotamine from liquid and powder formulations in rabbits.
Journal of pharmaceutical sciences 1997;86(7):802-7.
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1997: Marttin E; Verhoef J C; Cullander C; Romeijn S G; Nagelkerke J F; Merkus F W
Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: effects of absorption enhancers.
Pharmaceutical research 1997;14(5):631-7.
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1997: Romeijn S G; Marttin E; Verhoef J C; Merkus F W
Simplified solid-phase extraction method for determination of dihydroergotamine in rabbit and human serum using high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;692(1):227-32.
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1995: Marttin E; Verhoef J C; Romeijn S G; Merkus F W
Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity.
Pharmaceutical research 1995;12(8):1151-7.
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1995: Schipper N G; Verhoef J C; Romeijn S G; Merkus F W
Methylated beta-cyclodextrins are able to improve the nasal absorption of salmon calcitonin.
Calcified tissue international 1995;56(4):280-2.
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1995: Schols-Hendriks M W; Lohman J J; Janknegt R; Korten J J; Merkus F W; Hooymans P M
Absorption of clonazepam after intranasal and buccal administration.
British journal of clinical pharmacology 1995;39(4):449-51.
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1994: Schipper N G; Romeijn S G; Verhoef J; Merkus F W
Hypocalcemic effect of salmon calcitonin following single and repeated nasal and intravenous administration in young rabbits.
Calcified tissue international 1994;54(1):50-5.
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1993: Schipper N G; Verhoef J C; De Lannoy L M; Romeijn S G; Brakkee J H; Wiegant V M; Gispen W H; Merkus F W
Nasal administration of an ACTH(4-9) peptide analogue with dimethyl-beta-cyclodextrin as an absorption enhancer: pharmacokinetics and dynamics.
British journal of pharmacology 1993;110(4):1335-40.
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1993: Schipper N G; Romeijn S G; Verhoef J C; Merkus F W
Nasal insulin delivery with dimethyl-beta-cyclodextrin as an absorption enhancer in rabbits: powder more effective than liquid formulations.
Pharmaceutical research 1993;10(5):682-6.
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1992: Merkus F W; Schüsler-van Hees M T
Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance.
Allergy 1992;47(3):230-3.
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1992: Hermens W A; Belder C W; Merkus J M; Hooymans P M; Verhoef J; Merkus F W
Intranasal administration of estradiol in combination with progesterone to oophorectomized women: a pilot study.
European journal of obstetrics, gynecology, and reproductive biology 1992;43(1):65-70.
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1991: Merkus F W; Verhoef J C; Romeijn S G; Schipper N G
Interspecies differences in the nasal absorption of insulin.
Pharmaceutical research 1991;8(10):1343.
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1991: Schipper N G; Verhoef J C; Merkus F W
The nasal mucociliary clearance: relevance to nasal drug delivery.
Pharmaceutical research 1991;8(7):807-14.
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1991: Hermens W A; Belder C W; Merkus J M; Hooymans P M; Verhoef J; Merkus F W
Intranasal estradiol administration to oophorectomized women.
European journal of obstetrics, gynecology, and reproductive biology 1991;40(1):35-41.
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1991: Merkus F W; Verhoef J C; Romeijn S G; Schipper N G
Absorption enhancing effect of cyclodextrins on intranasally administered insulin in rats.
Pharmaceutical research 1991;8(5):588-92.
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1990: Hermens W A; Deurloo M J; Romeyn S G; Verhoef J C; Merkus F W
Nasal absorption enhancement of 17 beta-estradiol by dimethyl-beta-cyclodextrin in rabbits and rats.
Pharmaceutical research 1990;7(5):500-3.
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1990: Verhoef J C; Boddé H E; de Boer A G; Bouwstra J A; Junginger H E; Merkus F W; Breimer D D
Transport of peptide and protein drugs across biological membranes.
European journal of drug metabolism and pharmacokinetics 1990;15(2):83-93.
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1990: Hermens W A; Hooymans P M; Verhoef J C; Merkus F W
Effects of absorption enhancers on human nasal tissue ciliary movement in vitro.
Pharmaceutical research 1990;7(2):144-6.
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1989: Deurloo M J; Hermens W A; Romeyn S G; Verhoef J C; Merkus F W
Absorption enhancement of intranasally administered insulin by sodium taurodihydrofusidate (STDHF) in rabbits and rats.
Pharmaceutical research 1989;6(10):853-6.
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1987: Hermens W A; Merkus F W
The influence of drugs on nasal ciliary movement.
Pharmaceutical research 1987;4(6):445-9.
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1987: Lohman J J; Hooymans P M; Merkus F W
Digitoxin protein binding in hemodialysis patients and patients with normal renal function.
Clinical pharmacy 1987;6(7):565-7.
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1987: Lohman J J; Merkus F W
Plasma protein binding of digitoxin and some other drugs in renal disease.
Pharmaceutisch weekblad. Scientific edition 1987;9(2):75-8.
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1987: Overdiek H W; Merkus F W
The metabolism and biopharmaceutics of spironolactone in man.
Reviews on drug metabolism and drug interactions 1987;5(4):273-302.
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1986: Overdiek H W; Merkus F W
Influence of food on the bioavailability of spironolactone.
Clinical pharmacology and therapeutics 1986;40(5):531-6.
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1986: Cilissen J; Hooymans P M; Merkus F W
Modified fluorescence polarization immunoassay compared with radial partition immunoassay and a radioimmunoassay for digoxin.
Clinical chemistry 1986;32(11):2100.
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1986: Pieters F A; Zuidema J; Merkus F W
Sustained release properties of an intra-adiposely administered dapsone depot injection.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1986;54(3):383-8.
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1986: Zuidema J; Hilbers-Modderman E S; Merkus F W
Clinical pharmacokinetics of dapsone.
Clinical pharmacokinetics 1986;11(4):299-315.
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1986: Duchateau G S; Zuidema J; Merkus F W
The in vitro and in vivo effect of a new non-halogenated corticosteroid - budesonide - aerosol on human ciliary epithelial function.
Allergy 1986;41(4):260-5.
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1986: Overdiek J W; Merkus F W
Spironolactone metabolism and gynaecomastia.
Lancet 1986;1(8489):1103.
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1986: Hooymans P M; Merkus F W
[Pharmacokinetic interaction of drugs with cardiac glycosides; which are clinically important?]
Nederlands tijdschrift voor geneeskunde 1986;130(9):395-9.
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1985: Overdiek H W; Hermens W A; Merkus F W
New insights into the pharmacokinetics of spironolactone.
Clinical pharmacology and therapeutics 1985;38(4):469-74.
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1985: Duchateau G S; Graamans K; Zuidema J; Merkus F W
Correlation between nasal ciliary beat frequency and mucus transport rate in volunteers.
The Laryngoscope 1985;95(7 Pt 1):854-9.
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1985: Hooymans P M; Merkus F W
Current status of cardiac glycoside drug interactions.
Clinical pharmacy 1985;4(4):404-13.
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1985: Overdiek J W; Hermens W A; Merkus F W
Determination of the serum concentration of spironolactone and its metabolites by high-performance liquid chromatography.
Journal of chromatography 1985;341(2):279-85.
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1985: Lohman J J; Hooymans P M; Koten M L; Verhey M T; Merkus F W
Effect of heparin on digitoxin protein binding.
Clinical pharmacology and therapeutics 1985;37(1):55-60.
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1984: Lohman J J; Merkus F W; Costongs G M; Hegtermans E P; Hooymans P M
Pitfalls in the determination of unbound carbamazepine concentrations in plasma.
Pharmaceutisch weekblad. Scientific edition 1984;6(2):91-5.
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1983: Janknegt R; Lohman J J; Hooymans P M; Merkus F W
Do evacuated blood collection tubes interfere with therapeutic drug monitoring?
Pharmaceutisch weekblad. Scientific edition 1983;5(6):287-90.
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1983: Modderman E S; Merkus F W; Zuidema J; Hilbers H W; Warndorff T
Sex differences in the absorption of dapsone after intramuscular injection.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1983;51(3):359-65.
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1983: Modderman E S; Merkus F W; Zuidema J; Hilbers H W; Warndorff T
Dapsone levels after oral therapy and weekly oily injections in Ethiopian leprosy patients.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1983;51(2):191-6.
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1983: Merkus F W; Overdiek J W; Cilissen J; Zuidema J
Pharmacokinetics of spironolactone after a single dose: evaluation of the true canrenone serum concentrations during 24 hours.
Clinical and experimental hypertension. Part A, Theory and practice 1983;5(2):239-48.
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1982: van de Donk H J; van den Heuvel A G; Zuidema J; Merkus F W
The effects of nasal drops and their additives on human nasal mucociliary clearance.
Rhinology 1982;20(3):127-37.
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1982: van de Donk H J; Zuidema J; Merkus F W
Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.
Rhinology 1982;20(2):81-7.
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1982: van de Donk H J; Merkus F W
Decreases in ciliary beat frequency due to intranasal administration of propranolol.
Journal of pharmaceutical sciences 1982;71(5):595-6.
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1982: Hooymans P M; Cilissen J; Merkus F W
Assay of netilmicin in serum with the gentamicin radioimmunoassay kit.
American journal of hospital pharmacy 1982;39(5):784, 787-8.
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1982: Modderman E S; Huikeshoven H; Zuidema J; Leiker D L; Merkus F W
Intramuscular injection of dapsone in therapy for leprosy: a new approach.
International journal of clinical pharmacology, therapy, and toxicology 1982;20(2):51-6.
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1981: van de Donk H J; Zuidema J; Merkus F W
The effects of nasal drops on the ciliary beat frequency of chicken embryo tracheas.
Rhinology 1981;19(4):215-30.
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1981: Zuidema J; Verhoeven J; Merkus F W
Pharmacokinetics of etofylline after intravenous and oral administration to humans.
International journal of clinical pharmacology, therapy, and toxicology 1981;19(7):310-3.
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1980: van de Donk H J; Muller-Plantema I P; Zuidema J; Merkus F W
The effects of preservatives on the ciliary beat frequency of chicken embryo tracheas.
Rhinology 1980;18(3):119-33.
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1980: van de Donk H J; Zuidema J; Merkus F W
The influence of the pH and osmotic pressure upon tracheal ciliary beat frequency as determined with a new photo-electric registration device.
Rhinology 1980;18(2):93-104.
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1980: Zuidema J; Modderman E S; Hilbers H W; Merkus F W; Huikeshoven H
Rapid high-performance liquid chromatographic method for the determination of dapsone and monoacetyldapsone in biological fluids.
Journal of chromatography 1980;182(1):130-5.
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1980: Zuidema J; Merkus F W
N-Substituted theophylline derivatives.
American journal of hospital pharmacy 1980;37(2):169-70.
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1980: Merkus F W; Zuidema J
Theophylline and hydroxyethyltheophylline are different drugs.
International journal of clinical pharmacology, therapy, and toxicology 1980;18(2):97.
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