FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Alfred Merrill

Research Profile

Chemicals & Drugs

Living Beings

Mouse
Rats

Anatomy

Concepts & Ideas

Kinetics

Physiology

Signal Transduction

Co-author Network

Publications

TOP 3
Hila Zigdon; Ruth Goldschmidt; Samuel Kelly; Aviram Kogot-Levin; Alfred H Merrill; Joo-Won Park; Yael Pewzner-Jung; Ann Saada; Avigdor Scherz; Anthony H Futerman
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.
Alfred H Merrill; Robert C Murphy; William L Smith; Dennis E Vance; John E Wilson; Robert K Yu
In memoriam: Charles (Chuck) Crawford Sweeley, Jr. (1930-2012).
Natasha C Lucki; Alfred H Merrill; Sibali Bandyopadhyay; Donghui Li; Elaine Wang; Marion B Sewer
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Alfred Merrill (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Hila Zigdon; Ruth Goldschmidt; Samuel Kelly; Aviram Kogot-Levin; Alfred H Merrill; Joo-Won Park; Yael Pewzner-Jung; Ann Saada; Avigdor Scherz; Anthony H Futerman
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.
The Journal of biological chemistry 2013;288(7):4947-56.
2013: Alfred H Merrill; Robert C Murphy; William L Smith; Dennis E Vance; John E Wilson; Robert K Yu
In memoriam: Charles (Chuck) Crawford Sweeley, Jr. (1930-2012).
Journal of lipid research 2013;54(1):1-4.
2012: Natasha C Lucki; Alfred H Merrill; Sibali Bandyopadhyay; Donghui Li; Elaine Wang; Marion B Sewer
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.
Molecular and cellular biology 2012;32(21):4419-31.
2012: Nathanael J Spann; Shankar Subramaniam; M Cameron Sullards; Sotirios Tsimikas; Elaine W Wang; H Alex Brown; Edward A Dennis; Eoin Fahy; Jesse N Fox; Lana X Garmire; Daniel Heudobler; Samuel L Kelly; Klaus Ley; Andrew C Li; Jeffrey G McDonald; Alfred H Merrill; Stephen B Milne; Robert C Murphy; David S Myers; Oswald Quehenberger; Christian R H Raetz; Donna Reichart; David W Russell; Iftach Shaked; Norihito Shibata; Christopher K Glass
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
Cell 2012;151(1):138-52.
2012: Elad L Laviad; Alfred H Merrill; Samuel Kelly; Anthony H Futerman
Modulation of ceramide synthase activity via dimerization.
The Journal of biological chemistry 2012;287(25):21025-33.
2012: Nadine Hagen-Euteneuer; Dieter Lütjohann; Alfred H Merrill; Hyejung Park; Gerhild van Echten-Deckert
Sphingosine 1-phosphate (S1P) lyase deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.
The Journal of biological chemistry 2012;287(12):9128-36.
2012: Liana C Silva; Johnny Stiban; Sibali Bandyopadhyay; Oshrit Ben David; Elad L Laviad; Alfred H Merrill; Yael Pewzner-Jung; Manuel Prieto; Anthony H Futerman
Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.
Journal of lipid research 2012;53(3):430-6.
2012: Natasha C Lucki; Alfred H Merrill; Sibali Bandyopadhyay; Elaine Wang; Marion B Sewer
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.
Molecular endocrinology (Baltimore, Md.) 2012;26(2):228-43.
2012: Rotem Tidhar; Elaine Wang; Shifra Ben-Dor; Samuel Kelly; Alfred H Merrill; Anthony H Futerman
Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.
The Journal of biological chemistry 2012;287(5):3197-206.
2011: Robert C Murphy; Alfred H Merrill
Lipidomics and imaging mass spectrometry.
Biochimica et biophysica acta 2011;1811(11):635-6.
2011: M Cameron Sullards; Yanfeng Chen; Ying Liu; Alfred H Merrill
Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS).
Biochimica et biophysica acta 2011;1811(11):838-53.
2011: Alfred H Merrill
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.
Chemical reviews 2011;111(10):6387-422.
2011: Oshrit Ben-David; Inbal E Biton; Ori Brenner; Britta Brügger; Alon Friedman; Joseph Alroy; Samuel Kelly; Aviram Kogot-Levin; Elad L Laviad; Alfred H Merrill; Yael Pewzner-Jung; Reut Pienik; Annick Raas-Rothschild; Elaine Wang; Itai Weissberg; Anthony H Futerman
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
The Journal of biological chemistry 2011;286(34):30022-33.
2011: Christopher A Haynes; Samuel L Kelly; M Cameron Sullards; Elaine W Wang; Jeremy C Allegood; Alfred H Merrill
Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.
Journal of lipid research 2011;52(8):1583-94.
2011: Amin A Momin; Hyejung Park; Brent J Portz; Christopher A Haynes; Rebecca L Shaner; Samuel L Kelly; I King Jordan; Alfred H Merrill
A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.
Journal of lipid research 2011;52(6):1073-83.
2011: Mark Dickson; Richard Carvajal; Alfred H Merrill; Mithat Gonen; Lauren M Cane; Gary K Schwartz
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2484-92.
2011: Holly Symolon; Anatoliy Bushnev; Qiong Peng; Harsha Ramaraju; Suzanne G Mays; Jeremy C Allegood; Sarah T Pruett; M Cameron Sullards; Dirck L Dillehay; Dennis C Liotta; Alfred H Merrill
Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.
Molecular cancer therapeutics 2011;10(4):648-57.
2011: Chang F Quo; Richard A Moffitt; Alfred H Merrill; May D Wang
Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation.
Journal of computational biology : a journal of computational molecular cell biology 2011;18(2):169-82.
2011: Shakti Gupta; Mano Ram Maurya; Alfred H Merrill; Christopher K Glass; Shankar Subramaniam
Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism.
BMC systems biology 2011;5():26.
2010: Edward A Dennis; Raymond A Deems; Richard Harkewicz; Oswald Quehenberger; H Alex Brown; Stephen B Milne; David S Myers; Christopher K Glass; Gary Hardiman; Donna Reichart; Alfred H Merrill; M Cameron Sullards; Elaine Wang; Robert C Murphy; Christian R H Raetz; Teresa A Garrett; Ziqiang Guan; Andrea C Ryan; David W Russell; Jeffrey G McDonald; Bonne M Thompson; Walter A Shaw; Manish Sud; Yihua Zhao; Shakti Gupta; Mano R Maurya; Eoin Fahy; Shankar Subramaniam
A mouse macrophage lipidome.
The Journal of biological chemistry 2010;285(51):39976-85.
2010: Kacee Sims; Christopher A Haynes; Samuel Kelly; Jeremy C Allegood; Elaine Wang; Amin Momin; Martina Leipelt; Donna Reichart; Christopher K Glass; M Cameron Sullards; Alfred H Merrill
Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy.
The Journal of biological chemistry 2010;285(49):38568-79.
2010: Yanfeng Chen; Ying Liu; M Cameron Sullards; Alfred H Merrill
An introduction to sphingolipid metabolism and analysis by new technologies.
Neuromolecular medicine 2010;12(4):306-19.
2010: Oswald Quehenberger; Aaron M Armando; Alex H Brown; Stephen B Milne; David S Myers; Alfred H Merrill; Sibali Bandyopadhyay; Kristin N Jones; Samuel Kelly; Rebecca L Shaner; Cameron M Sullards; Elaine Wang; Robert C Murphy; Robert M Barkley; Thomas J Leiker; Christian R H Raetz; Ziqiang Guan; Gregory M Laird; David A Six; David W Russell; Jeffrey G McDonald; Shankar Subramaniam; Eoin Fahy; Edward A Dennis
Lipidomics reveals a remarkable diversity of lipids in human plasma.
Journal of lipid research 2010;51(11):3299-305.
2010: Alexander Y Andreyev; Eoin Fahy; Ziqiang Guan; Samuel Kelly; Xiang Li; Jeffrey G McDonald; Stephen Milne; David Myers; Hyejung Park; Andrea Ryan; Bonne M Thompson; Elaine Wang; Yihua Zhao; H Alex Brown; Alfred H Merrill; Christian R H Raetz; David W Russell; Shankar Subramaniam; Edward A Dennis
Subcellular organelle lipidomics in TLR-4-activated macrophages.
Journal of lipid research 2010;51(9):2785-97.
2010: Jun Yin; Keiko Miyazaki; Rebecca L Shaner; Alfred H Merrill; Reiji Kannagi
Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers.
FEBS letters 2010;584(9):1872-8.
2010: Yael Pewzner-Jung; Ori Brenner; Svantje Braun; Elad L Laviad; Shifra Ben-Dor; Ester Feldmesser; Shirley Horn-Saban; Daniela Amann-Zalcenstein; Calanit Raanan; Tamara Berkutzki; Racheli Erez-Roman; Oshrit Ben-David; Michal Levy; Dorin Holzman; Hyejung Park; Abraham Nyska; Alfred H Merrill; Anthony H Futerman
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.
The Journal of biological chemistry 2010;285(14):10911-23.
2010: Yael Pewzner-Jung; Hyejung Park; Elad L Laviad; Liana Silva; Sujoy Lahiri; Johnny Stiban; Racheli Erez-Roman; Britta Brügger; Timo Sachsenheimer; Felix Wieland; Manuel Prieto; Alfred H Merrill; Anthony H Futerman
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways.
The Journal of biological chemistry 2010;285(14):10902-10.
2010: Hyejung Park; Christopher A Haynes; Alison V Nairn; Michael Kulik; Stephen Dalton; Kelley W Moremen; Alfred H Merrill
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies.
Journal of lipid research 2010;51(3):480-9.
2010: Yanfeng Chen; Ying Liu; Jeremy C Allegood; Elaine Wang; Begoña Cachón-González; Timothy M Cox; Alfred H Merrill; M Cameron Sullards
Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system.
Methods in molecular biology (Clifton, N.J.) 2010;656():131-46.
2010: Ying Liu; Yanfeng Chen; Amin Momin; Rebecca Shaner; Elaine Wang; Nathan Bowen; Lilya V Matyunina; L Deette Walker; John F McDonald; M Cameron Sullards; Alfred H Merrill
Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry.
Molecular cancer 2010;9():186.
2009: Wei Hu; Jacek Bielawski; Fahumiya Samad; Alfred H Merrill; L Ashley Cowart
Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.
Journal of lipid research 2009;50(9):1852-62.
2009: Amin A Momin; Hyejung Park; Jeremy C Allegood; Martina Leipelt; Samuel L Kelly; Alfred H Merrill; Kentaro Hanada
Characterization of mutant serine palmitoyltransferase 1 in LY-B cells.
Lipids 2009;44(8):725-32.
2009: Jia Wei; Tokunbo Yerokun; Martina Leipelt; Chris A Haynes; Harish Radhakrishna; Amin Momin; Samuel Kelly; Hyejung Park; Elaine Wang; Jill M Carton; David J Uhlinger; Alfred H Merrill
Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology.
Biochimica et biophysica acta 2009;1791(8):746-56.
2009: Rebecca L Shaner; Jeremy C Allegood; Hyejung Park; Elaine Wang; Samuel Kelly; Christopher A Haynes; M Cameron Sullards; Alfred H Merrill
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers.
Journal of lipid research 2009;50(8):1692-707.
2009: Meidan Goldfinger; Elad L Laviad; Rivka Hadar; Miri Shmuel; Arie Dagan; Hyejung Park; Alfred H Merrill; Israel Ringel; Anthony H Futerman; Boaz Tirosh
De novo ceramide synthesis is required for N-linked glycosylation in plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7038-47.
2009: Nadine Hagen; Paul P Van Veldhoven; Richard L Proia; Hyejung Park; Alfred H Merrill; Gerhild van Echten-Deckert
Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons.
The Journal of biological chemistry 2009;284(17):11346-53.
2009: Alfred H Merrill; Todd H Stokes; Amin Momin; Hyejung Park; Brent J Portz; Samuel Kelly; Elaine Wang; M Cameron Sullards; May Dongmei Wang
Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease.
Journal of lipid research 2009;50 Suppl():S97-102.
2009: Gergana M Deevska; Krassimira A Rozenova; Natalia V Giltiay; Melissa A Chambers; James White; Boris B Boyanovsky; Jia Wei; Alan Daugherty; Eric J Smart; Michael B Reid; Alfred H Merrill; Mariana Nikolova-Karakashian
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.
The Journal of biological chemistry 2009;284(13):8359-68.
2009: Nicholas C Zitomer; Trevor Mitchell; Kenneth A Voss; Genevieve S Bondy; Sarah T Pruett; Ethel C Garnier-Amblard; Lanny S Liebeskind; Hyejung Park; Elaine Wang; M Cameron Sullards; Alfred H Merrill; Ronald T Riley
Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.
The Journal of biological chemistry 2009;284(8):4786-95.
2009: Jesse Coward; Grazia Ambrosini; Elgilda Musi; Jean-Philip Truman; Adriana Haimovitz-Friedman; Jeremy C Allegood; Elaine Wang; Alfred H Merrill; Gary K Schwartz
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.
Autophagy 2009;5(2):184-93.
2008: Nicholas J Machesky; Guojuan Zhang; Bindu Raghavan; Pete Zimmerman; Samuel L Kelly; Alfred H Merrill; W James Waldman; James R Van Brocklyn; Joanne Trgovcich
Human cytomegalovirus regulates bioactive sphingolipids.
The Journal of biological chemistry 2008;283(38):26148-60.
2008: Hongtao Wang; Barry J Maurer; Yong-Yu Liu; Elaine Wang; Jeremy C Allegood; Samuel Kelly; Holly Symolon; Ying Liu; Alfred H Merrill; Valérie Gouazé-Andersson; Jing Yuan Yu; Armando E Giuliano; Myles C Cabot
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
Molecular cancer therapeutics 2008;7(9):2967-76.
2008: Sarah T Pruett; Anatoliy Bushnev; Kerri Hagedorn; Madhura Adiga; Christopher A Haynes; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.
Journal of lipid research 2008;49(8):1621-39.
2008: Christopher A Haynes; Jeremy C Allegood; Kacee Sims; Elaine W Wang; M Cameron Sullards; Alfred H Merrill
Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal of lipid research 2008;49(5):1113-25.
2008: Yanfeng Chen; Jeremy C Allegood; Ying Liu; Elaine Wang; Begoña Cachón-Gonzalez; Timothy M Cox; Alfred H Merrill; M Cameron Sullards
Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease.
Analytical chemistry 2008;80(8):2780-8.
2008: Elad L Laviad; Lee Albee; Irene Pankova-Kholmyansky; Sharon Epstein; Hyejung Park; Alfred H Merrill; Anthony H Futerman
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.
The Journal of biological chemistry 2008;283(9):5677-84.
2008: Shray Kapoor; Chang Feng Quo; Alfred H Merrill; May Dongmei Wang
An interactive visualization tool and data model for experimental design in systems biology.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008;2008():2423-6.
2007: Olga Torres; Edwin Palencia; Ligia Lopez de Pratdesaba; Ruben Grajeda; Mario Fuentes; Marcy C Speer; Alfred H Merrill; Kerry O'Donnell; Charles W Bacon; Anthony E Glenn; Ronald T Riley
Estimated fumonisin exposure in Guatemala is greatest in consumers of lowland maize.
The Journal of nutrition 2007;137(12):2723-9.
2007: Alfred H Merrill; May Dongmei Wang; Meeyoung Park; M Cameron Sullards
(Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology.
Trends in biochemical sciences 2007;32(10):457-68.
2007: Dayong Wu; Zhihong Ren; Munkyong Pae; Weimin Guo; Xuelin Cui; Alfred H Merrill; Simin Nikbin Meydani
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4829-39.
2007: Donghui Li; Aarti N Urs; Jeremy C Allegood; Adam Leon; Alfred H Merrill; Marion B Sewer
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Molecular and cellular biology 2007;27(19):6669-85.
2007: Michaela Seiferlein; Hans-Ulrich Humpf; Kenneth A Voss; M Cameron Sullards; Jeremy C Allegood; Elaine Wang; Alfred H Merrill
Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.
Molecular nutrition & food research 2007;51(9):1120-30.
2007: Raghavendra Pralhada Rao; Changqing Yuan; Jeremy C Allegood; Satinder Rawat; Michael Beth Edwards; Xin Wang; Alfred H Merrill; Usha Acharya; Jairaj K Acharya
Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11364-9.
2007: Nadia F Lamour; Robert V Stahelin; Dayanjan S Wijesinghe; Michael Maceyka; Elaine Wang; Jeremy C Allegood; Alfred H Merrill; Wonhwa Cho; Charles E Chalfant
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
Journal of lipid research 2007;48(6):1293-304.
2007: Catherine M Finnegan; Satinder Rawat; Edward Cho; Danielle L Guiffre; Stephen Lockett; Alfred H Merrill; Robert Blumenthal
Sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion.
Journal of virology 2007;81(10):5294-304.
2007: Aarti N Urs; Eric B Dammer; Samuel Kelly; Elaine Wang; Alfred H Merrill; Marion B Sewer
Steroidogenic factor-1 is a sphingolipid binding protein.
Molecular and cellular endocrinology 2007;265-266():174-8.
2007: Shobhika Dhingra; Melissa Freedenberg; Chang Quo; Alfred H Merrill; May Dongmei Wang
Computational modeling of a metabolic pathway in ceramide de novo synthesis.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007;2007():1405-8.
2007: M Cameron Sullards; Jeremy C Allegood; Samuel Kelly; Elaine Wang; Christopher A Haynes; Hyejung Park; Yanfeng Chen; Alfred H Merrill
Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics.
Methods in enzymology 2007;432():83-115.
2007: Pablo R Morales; Dirck L Dillehay; Steven J Moody; David C Pallas; Sarah Pruett; Jeremy C Allgood; Holly Symolon; Alfred H Merrill
Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation.
Drug and chemical toxicology 2007;30(3):197-216.
2007: Manish Sud; Eoin Fahy; Dawn Cotter; Alex Brown; Edward A Dennis; Christopher K Glass; Alfred H Merrill; Robert C Murphy; Christian R H Raetz; David W Russell; Shankar Subramaniam
LMSD: LIPID MAPS structure database.
Nucleic acids research 2007;35(Database issue):D527-32.
2007: Sandii N Brimble; Eric S Sherrer; Elizabeth W Uhl; Elaine Wang; Samuel Kelly; Alfred H Merrill; Allan J Robins; Thomas C Schulz
The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency.
Stem cells (Dayton, Ohio) 2007;25(1):54-62.
2006: Todd E Fox; Xianlin Han; Samuel Kelly; Alfred H Merrill; Rex E Martin; Robert E Anderson; Thomas Gardner; Mark Kester
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.
Diabetes 2006;55(12):3573-80.
2006: Wenjing Zheng; Jessica Kollmeyer; Holly Symolon; Amin Momin; Elizabeth Munter; Elaine Wang; Samuel Kelly; Jeremy C Allegood; Ying Liu; Qiong Peng; Harsha Ramaraju; M Cameron Sullards; Myles Cabot; Alfred H Merrill
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.
Biochimica et biophysica acta 2006;1758(12):1864-84.
2006: Stephen C Linn; Lindsay M Andras; Hee-Sook Kim; Jia Wei; M Marek Nagiec; Robert C Dickson; Alfred H Merrill
Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase.
FEBS letters 2006;580(26):6217-23.
2006: Mihaela Dragusin; Sven Wehner; Samuel Kelly; Elaine Wang; Alfred H Merrill; Jörg C Kalff; Gerhild van Echten-Deckert
Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1930-2.
2006: Paola Giussani; Michael Maceyka; Hervé Le Stunff; Aki Mikami; Sandrine Lépine; Elaine Wang; Samuel Kelly; Alfred H Merrill; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
Molecular and cellular biology 2006;26(13):5055-69.
2006: Philipp C Rittershaus; Talar B Kechichian; Jeremy C Allegood; Alfred H Merrill; Mirko Hennig; Chiara Luberto; Maurizio Del Poeta
Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.
The Journal of clinical investigation 2006;116(6):1651-9.
2006: Ann M Dougherty; Frank E McDonald; Dennis C Liotta; Steven J Moody; David C Pallas; Carrie D Pack; Alfred H Merrill
Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.
Organic letters 2006;8(4):649-52.
2006: Stacey A Missmer; Lucina Suarez; Marilyn Felkner; Elaine Wang; Alfred H Merrill; Kenneth J Rothman; Kate Hendricks
Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border.
Environmental health perspectives 2006;114(2):237-41.
2005: Michael Maceyka; Heidi Sankala; Nitai C Hait; Hervé Le Stunff; Hong Liu; Rachelle E Toman; Claiborne Collier; Min Zhang; Leslie S Satin; Alfred H Merrill; Sheldon Milstien; Sarah Spiegel
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
The Journal of biological chemistry 2005;280(44):37118-29.
2005: Alfred H Merrill; M Cameron Sullards; Jeremy C Allegood; Samuel Kelly; Elaine Wang
Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.
Methods (San Diego, Calif.) 2005;36(2):207-24.
2005: Eoin Fahy; Shankar Subramaniam; H Alex Brown; Christopher K Glass; Alfred H Merrill; Robert C Murphy; Christian R H Raetz; David W Russell; Yousuke Seyama; Walter Shaw; Takao Shimizu; Friedrich Spener; Gerrit van Meer; Michael S VanNieuwenhze; Stephen H White; Joseph L Witztum; Edward A Dennis
A comprehensive classification system for lipids.
Journal of lipid research 2005;46(5):839-61.
2005: Peter Henning; Richard Moffitt; Jeremy C Allegood; Elaine Wang; Alfred H Merrill; May Dongmei Wang
Computationally predicting rate constants in pathway models.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2005;5():5093-6.
2004: Tuba Ozbay; Alfred H Merrill; Marion B Sewer
ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism.
Endocrine research 2004;30(4):787-94.
2004: Martha M Monick; Rama K Mallampalli; Mary A Bradford; Diann M McCoy; Thomas J Gross; Dawn M Flaherty; Linda S Powers; Kelli Cameron; Samuel Kelly; Alfred H Merrill; Gary W Hunninghake
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):123-35.
2004: Holly Symolon; Eva M. Schmelz; Dirck L Dillehay; Alfred H Merrill
Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice.
The Journal of nutrition 2004;134(5):1157-61.
2004: Walter F O Marasas; Ronald T Riley; Kate Hendricks; Victoria L Stevens; Thomas W Sadler; Janee Gelineau-van Waes; Stacey A Missmer; Julio Cabrera; Olga Torres; Wentzel C A Gelderblom; Jeremy C Allegood; Carolina Martínez; Joyce Maddox; J David Miller; Lois Starr; M Cameron Sullards; Ana Victoria Roman; Kenneth A Voss; Elaine Wang; Alfred H Merrill
Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize.
The Journal of nutrition 2004;134(4):711-6.
2004: Vadim N Dedov; Irina V Dedova; Alfred H Merrill; Garth A Nicholson
Activity of partially inhibited serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells.
Biochimica et biophysica acta 2004;1688(2):168-75.
2004: Ulrike Reiss; Babak Oskouian; Jianhui Zhou; Vinita Gupta; Prathap Sooriyakumaran; Samuel Kelly; Elaine Wang; Alfred H Merrill; Julie Saba
Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
The Journal of biological chemistry 2004;279(2):1281-90.
2004: Peter A Henning; Alfred H Merrill; May Dongmei Wang
Dynamic pathway modeling of sphingolipid metabolism.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;4():2913-6.
2003: Christian Riebeling; Jeremy C Allegood; Elaine Wang; Alfred H Merrill; Anthony H Futerman
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
The Journal of biological chemistry 2003;278(44):43452-9.
2003: M Cameron Sullards; Elaine Wang; Qiong Peng; Alfred H Merrill
Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(5):789-97.
2003: David S Menaldino; Anatoliy Bushnev; Aiming Sun; Dennis C Liotta; Holly Symolon; Kena Desai; Dirck L Dillehay; Qiong Peng; Elaine Wang; Jeremy C Allegood; Sarah Trotman-Pruett; M Cameron Sullards; Alfred H Merrill
Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(5):373-81.
2002: Kena Desai; M Cameron Sullards; Jeremy C Allegood; Elaine Wang; Eva M. Schmelz; Michaela Hartl; Hans-Ulrich Humpf; Dennis C Liotta; Qiong Peng; Alfred H Merrill
Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):188-92.
2002: Thomas W Sadler; Alfred H Merrill; Victoria L Stevens; M Cameron Sullards; Elaine Wang; Ping Wang
Prevention of fumonisin B1-induced neural tube defects by folic acid.
Teratology 2002;66(4):169-76.
2002: Krishnan Venkataraman; Christian Riebeling; Jacques Bodennec; Howard Riezman; Jeremy C Allegood; M Cameron Sullards; Alfred H Merrill; Anthony H Futerman
Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.
The Journal of biological chemistry 2002;277(38):35642-9.
2002: Emma Patten Hitt; Mary J DeLong; Alfred H Merrill
Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.
Toxicology and applied pharmacology 2002;183(3):160-7.
2002: William L Smith; Alfred H Merrill
Sphingolipid metabolism and signaling minireview series.
The Journal of biological chemistry 2002;277(29):25841-2.
2002: Alfred H Merrill
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
The Journal of biological chemistry 2002;277(29):25843-6.
2001: Christian C Abnet; Craig B Borkowf; You-Lin Qiao; Paul S Albert; E Wang; Alfred H Merrill; Steven D Mark; Zhi-Wei Dong; Philip R Taylor; Sanford M Dawsey
Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china.
Cancer causes & control : CCC 2001;12(9):821-8.
2001: S C Linn; H S Kim; E M Keane; L M Andras; Elaine Wang; Alfred H Merrill
Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption.
Biochemical Society transactions 2001;29(Pt 6):831-5.
2001: Christian C Abnet; Craig B Borkowf; You-Lin Qiao; Paul S Albert; E Wang; Alfred H Merrill; Steven D Mark; Zhi-Wei Dong; Philip R Taylor; Sanford M Dawsey
A cross-sectional study of human serum sphingolipids, diet and physiologic parameters.
The Journal of nutrition 2001;131(10):2748-52.
2001: Eva M. Schmelz; Paul C Roberts; E M Kustin; Lori A Lemonnier; M Cameron Sullards; Dirck L Dillehay; Alfred H Merrill
Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.
Cancer research 2001;61(18):6723-9.
2001: Ronald T Riley; EN Enongene; Kenneth A Voss; William Norred; Filmore I Meredith; Raghubir P Sharma; J Spitsbergen; DE Williams; DB Carlson; Alfred H Merrill
Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
Environmental health perspectives 2001;109 Suppl 2():301-8.
2001: Alfred H Merrill; M Cameron Sullards; Elaine Wang; Kenneth A Voss; Ronald T Riley
Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
Environmental health perspectives 2001;109 Suppl 2():283-9.
2001: M Cameron Sullards; Alfred H Merrill
Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
Science's STKE : signal transduction knowledge environment 2001;2001(67):pl1.
2000: T B Caligan; K Peters; J Ou; Elaine Wang; J Saba; Alfred H Merrill
A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples.
Analytical biochemistry 2000;281(1):36-44.
2000: C Grullich; M Cameron Sullards; Zvi Fuks; Alfred H Merrill; Richard Kolesnick
CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis.
The Journal of biological chemistry 2000;275(12):8650-6.
2000: M Cameron Sullards; D V Lynch; Alfred H Merrill; J Adams
Structure determination of soybean and wheat glucosylceramides by tandem mass spectrometry.
Journal of mass spectrometry : JMS 2000;35(3):347-53.
2000: Eva M. Schmelz; M Cameron Sullards; Dirck L Dillehay; Alfred H Merrill
Colonic cell proliferation and aberrant crypt foci formation are inhibited by dairy glycosphingolipids in 1, 2-dimethylhydrazine-treated CF1 mice.
The Journal of nutrition 2000;130(3):522-7.
2000: Alfred H Merrill; B B Bowman; P C Preusch
Mechanistic aspects of vitamin and coenzyme utilization and function: a symposium in recognition of the distinguished career of Donald B. McCormick.
The Journal of nutrition 2000;130(2S Suppl):321S-322S.
2000: Alfred H Merrill
Compilation of methods published in previous volumes of Methods in Enzymology.
Methods in enzymology 2000;312():583-92.
2000: Elizabeth Smith; Alfred H Merrill; Lina M Obeid; Yusuf A Hannun
Effects of sphingosine and other sphingolipids on protein kinase C.
Methods in enzymology 2000;312():361-73.
2000: Alfred H Merrill; T B Caligan; Elaine Wang; K Peters; J Ou
Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography.
Methods in enzymology 2000;312():3-9.
2000: Mariana Nikolova-Karakashian; Alfred H Merrill
Ceramidases.
Methods in enzymology 2000;311():194-201.
2000: Elaine Wang; Alfred H Merrill
Ceramide synthase.
Methods in enzymology 2000;311():15-21.
1999: lisa Ann warden; David S Menaldino; T Wilson; Dennis C Liotta; Elizabeth Smith; Alfred H Merrill
Identification of ammonium ion and 2,6-bis(omega-aminobutyl)- 3, 5-diiminopiperazine as endogenous factors that account for the "burst" of sphingosine upon changing the medium of J774 cells in culture.
The Journal of biological chemistry 1999;274(48):33875-80.
1999: Eva M. Schmelz; Anatoliy Bushnev; Dirck L Dillehay; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis.
Cancer research 1999;59(22):5768-72.
1999: Filmore I Meredith; Olga Torres; S Saenz de Tejada; Ronald T Riley; Alfred H Merrill
Fumonisin B1 and hydrolyzed fumonisin B1 (AP1) in tortillas and nixtamalized corn (Zea mays L.) from two different geographic locations in Guatemala.
Journal of food protection 1999;62(10):1218-22.
1999: Alfred H Merrill; Edward T Morgan; Mariana Nikolova-Karakashian; Juarine Stewart
Sphingomyelin hydrolysis and regulation of the expression of the gene for cytochrome P450.
Biochemical Society transactions 1999;27(4):383-7.
1999: Nathalie Augé; Mariana Nikolova-Karakashian; S Carpentier; Sampath Parthasarathy; Anne Nègre-Salvayre; Robert Salvayre; Alfred H Merrill; Thierry Levade
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase.
The Journal of biological chemistry 1999;274(31):21533-8.
1999: H Vesper; Eva M. Schmelz; Mariana Nikolova-Karakashian; Dirck L Dillehay; D V Lynch; Alfred H Merrill
Sphingolipids in food and the emerging importance of sphingolipids to nutrition.
The Journal of nutrition 1999;129(7):1239-50.
1999: Ronald T Riley; William Norred; E Wang; Alfred H Merrill
Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices.
Natural toxins 1999;7(6):407-14.
1999: Elaine Wang; Ronald T Riley; Filmore I Meredith; Alfred H Merrill
Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine.
The Journal of nutrition 1999;129(1):214-20.
1998: Eva M. Schmelz; Alfred H Merrill
Ceramides and ceramide metabolites in cell regulation: evidence for dietary sphingolipids as inhibitors of colon carcinogenesis.
Nutrition (Burbank, Los Angeles County, Calif.) 1998;14(9):717-9.
1998: JR Ciacci-Zanella; Alfred H Merrill; E Wang; Clinton Jones
Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(9-10):791-804.
1998: Hans-Ulrich Humpf; Eva M. Schmelz; Filmore I Meredith; H Vesper; T R Vales; Elaine Wang; David S Menaldino; Dennis C Liotta; Alfred H Merrill
Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
The Journal of biological chemistry 1998;273(30):19060-4.
1998: William Norred; Kenneth A Voss; Ronald T Riley; Filmore I Meredith; Charles W Bacon; Alfred H Merrill
Mycotoxins and health hazards: toxicological aspects and mechanism of action of fumonisins.
The Journal of toxicological sciences 1998;23 Suppl 2():160-4.
1998: Eva M. Schmelz; M A Dombrink-Kurtzman; Paul C Roberts; Y Kozutsumi; T Kawasaki; Alfred H Merrill
Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases.
Toxicology and applied pharmacology 1998;148(2):252-60.
1998: Diane F Birt; Alfred H Merrill; T Barnett; B Enkvetchakul; Parviz M Pour; Dennis C Liotta; V Geisler; David S Menaldino; J Schwartzbauer
Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine.
Nutrition and cancer 1998;31(2):119-26.
1997: C Michel; Gerhild van Echten-Deckert; J Rother; Konrad Sandhoff; E Wang; Alfred H Merrill
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
The Journal of biological chemistry 1997;272(36):22432-7.
1997: Mariana Nikolova-Karakashian; R W Russell; R A Booth; D J Jenden; Alfred H Merrill
Sphingomyelin metabolism in rat liver after chronic dietary replacement of choline by N-aminodeanol.
Journal of lipid research 1997;38(9):1764-70.
1997: Jan Willem Kok; Mariana Nikolova-Karakashian; Karin Klappe; C Alexander; Alfred H Merrill
Dihydroceramide biology. Structure-specific metabolism and intracellular localization.
The Journal of biological chemistry 1997;272(34):21128-36.
1997: Mariana Nikolova-Karakashian; Edward T Morgan; C Alexander; Dennis C Liotta; Alfred H Merrill
Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.
The Journal of biological chemistry 1997;272(30):18718-24.
1997: Alfred H Merrill; Eva M. Schmelz; Elaine Wang; Dirck L Dillehay; L G Rice; Filmore I Meredith; Ronald T Riley
Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets.
The Journal of nutrition 1997;127(5 Suppl):830S-833S.
1997: Elizabeth Smith; P L Jones; Jeremy M Boss; Alfred H Merrill
Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases.
The Journal of biological chemistry 1997;272(9):5640-6.
1997: Eva M. Schmelz; Anatoliy Bushnev; Dirck L Dillehay; Dennis C Liotta; Alfred H Merrill
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Nutrition and cancer 1997;28(1):81-5.
1997: Alfred H Merrill; Eva M. Schmelz; Dirck L Dillehay; S Spiegel; James A Shayman; J J Schroeder; Ronald T Riley; Kenneth A Voss; Elaine Wang
Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
Toxicology and applied pharmacology 1997;142(1):208-25.
1996: Eva M. Schmelz; Dirck L Dillehay; Sonji K Webb; A Reiter; J Adams; Alfred H Merrill
Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis.
Cancer research 1996;56(21):4936-41.
1996: Sarah Spiegel; Alfred H Merrill
Sphingolipid metabolism and cell growth regulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(12):1388-97.
1996: Alfred H Merrill; Dennis C Liotta; Ronald T Riley
Fumonisins: fungal toxins that shed light on sphingolipid function.
Trends in cell biology 1996;6(6):218-23.
1996: C Zacharias; Gerhild van Echten-Deckert; E Wang; Alfred H Merrill; Konrad Sandhoff
The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes.
Glycoconjugate journal 1996;13(2):167-75.
1996: Alfred H Merrill; Elaine Wang; T R Vales; Elizabeth Smith; J J Schroeder; David S Menaldino; C Alexander; H M Crane; J Xia; Dennis C Liotta; Filmore I Meredith; Ronald T Riley
Fumonisin toxicity and sphingolipid biosynthesis.
Advances in experimental medicine and biology 1996;392():297-306.
1996: Edward T Morgan; Mariana Nikolova-Karakashian; J Q Chen; Alfred H Merrill
Sphingolipid-dependent signaling in regulation of cytochrome P450 expression.
Methods in enzymology 1996;272():381-8.
1996: Ronald T Riley; Elaine Wang; J J Schroeder; Elizabeth Smith; R D Plattner; Hamed K Abbas; H S Yoo; Alfred H Merrill
Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins.
Natural toxins 1996;4(1):3-15.
1995: J C Restum; Steven J Bursian; M Millerick; JA Render; Alfred H Merrill; E Wang; G E Rottinghaus; Richard J Aulerich
Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink.
Archives of environmental contamination and toxicology 1995;29(4):545-50.
1995: J Chen; Mariana Nikolova-Karakashian; Alfred H Merrill; Edward T Morgan
Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes.
The Journal of biological chemistry 1995;270(42):25233-8.
1995: Elizabeth Smith; Alfred H Merrill
Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture.
The Journal of biological chemistry 1995;270(32):18749-58.
1995: S Ramasamy; E Wang; Bernhard Hennig; Alfred H Merrill
Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture.
Toxicology and applied pharmacology 1995;133(2):343-8.
1995: Alfred H Merrill; S Lingrell; Elaine Wang; Mariana Nikolova-Karakashian; T R Vales; D E Vance
Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion.
The Journal of biological chemistry 1995;270(23):13834-41.
1995: Wen-I Wu; V M McDonough; J T Nickels; J Ko; A S Fischl; T R Vales; Alfred H Merrill; George M Carman
Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1.
The Journal of biological chemistry 1995;270(22):13171-8.
1995: Alfred H Merrill; Eva M. Schmelz; Elaine Wang; J J Schroeder; Dirck L Dillehay; Ronald T Riley
Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases.
The Journal of nutrition 1995;125(6 Suppl):1677S-1682S.
1995: E A Martinova; Alfred H Merrill
Fumonisin B1 alters sphingolipid metabolism and immune function in BALB/c mice: immunological responses to fumonisin B1.
Mycopathologia 1995;130(3):163-70.
1995: M Pushkareva; R Chao; Alicja Bielawska; Alfred H Merrill; H M Crane; B Lagu; Dennis C Liotta; Yusuf A Hannun
Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine.
Biochemistry 1995;34(6):1885-92.
1994: Eva M. Schmelz; K J Crall; R Larocque; Dirck L Dillehay; Alfred H Merrill
Uptake and metabolism of sphingolipids in isolated intestinal loops of mice.
The Journal of nutrition 1994;124(5):702-12.
1994: Dirck L Dillehay; Sonji K Webb; Eva M. Schmelz; Alfred H Merrill
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
The Journal of nutrition 1994;124(5):615-20.
1994: Ronald T Riley; D M Hinton; W J Chamberlain; Charles W Bacon; E Wang; Alfred H Merrill; Kenneth A Voss
Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity.
The Journal of nutrition 1994;124(4):594-603.
1994: J J Schroeder; H M Crane; J Xia; Dennis C Liotta; Alfred H Merrill
Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.
The Journal of biological chemistry 1994;269(5):3475-81.
1993: Alfred H Merrill; G van Echten; E Wang; K Sandhoff
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
The Journal of biological chemistry 1993;268(36):27299-306.
1993: Alfred H Merrill
Comment by A. H. Merrill, associate editor.
The Journal of nutrition 1993;123(9):1605.
1993: Alfred H Merrill
Apo A-IV: a new satiety signal.
Nutrition reviews 1993;51(9):273-5.
1993: Wen-I Wu; Y P Lin; E Wang; Alfred H Merrill; George M Carman
Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases.
The Journal of biological chemistry 1993;268(19):13830-7.
1993: T S Weibking; David R Ledoux; Alex J Bermudez; James Turk; G E Rottinghaus; E Wang; Alfred H Merrill
Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick.
Poultry science 1993;72(3):456-66.
1993: Z Zhang; Elizabeth Smith; Scott M Surowiec; Alfred H Merrill; D B McCormick
Synthesis of N-(4'-pyridoxyl)sphingosine and its uptake and metabolism by isolated cells.
Membrane biochemistry 1993;10(1):53-9.
1993: Ronald T Riley; N H An; J L Showker; H S Yoo; William Norred; W J Chamberlain; E Wang; Alfred H Merrill; G Motelin; Val R Beasley
Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs.
Toxicology and applied pharmacology 1993;118(1):105-12.
1993: Alfred H Merrill; E Wang; D G Gilchrist; Ronald T Riley
Fumonisins and other inhibitors of de novo sphingolipid biosynthesis.
Advances in lipid research 1993;26():215-34.
1993: Alfred H Merrill; J J Schroeder
Lipid modulation of cell function.
Annual review of nutrition 1993;13():539-59.
1993: Alfred H Merrill; Yusuf A Hannun; R M Bell
Introduction: sphingolipids and their metabolites in cell regulation.
Advances in lipid research 1993;25():1-24.
1993: C Borek; Alfred H Merrill
Sphingolipids inhibit multistage carcinogenesis and protein kinase C.
Basic life sciences 1993;61():367-71.
1992: Elaine Wang; P F Ross; T M Wilson; Ronald T Riley; Alfred H Merrill
Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme.
The Journal of nutrition 1992;122(8):1706-16.
1992: Alfred H Merrill; E Wang; R LaRocque; R E Mullins; Edward T Morgan; J L Hargrove; H L Bonkovsky; I A Popova
Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(2 Suppl):142S-147S.
1992: Alfred H Merrill; E Wang; R E Mullins; Richard E Grindeland; I A Popova
Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(2 Suppl):132S-135S.
1992: H S Yoo; William Norred; E Wang; Alfred H Merrill; Ronald T Riley
Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells.
Toxicology and applied pharmacology 1992;114(1):9-15.
1992: Alfred H Merrill
Ceramide: a new lipid "second messenger"?
Nutrition reviews 1992;50(3):78-80.
1992: B Enkvetchakul; T Barnett; Dennis C Liotta; V Geisler; David S Menaldino; Alfred H Merrill; Diane F Birt
Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice.
Cancer letters 1992;62(1):35-42.
1992: William Norred; E Wang; H Yoo; Ronald T Riley; Alfred H Merrill
In vitro toxicology of fumonisins and the mechanistic implications.
Mycopathologia 1992;117(1-2):73-8.
1992: Alfred H Merrill; E Wang
Enzymes of ceramide biosynthesis.
Methods in enzymology 1992;209():427-37.
1991: E Wang; William Norred; Charles W Bacon; Ronald T Riley; Alfred H Merrill
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme.
The Journal of biological chemistry 1991;266(22):14486-90.
1991: D J Uhlinger; D N Burnham; R E Mullins; J R Kalmar; C W Cutler; Roland R Arnold; David J. Lambeth; Alfred H Merrill
Functional differences in human neutrophils isolated pre- and post-prandially.
FEBS letters 1991;286(1-2):28-32.
1991: C Borek; A Ong; V L Stevens; E Wang; Alfred H Merrill
Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1953-7.
1991: Alfred H Merrill
Cell regulation by sphingosine and more complex sphingolipids.
Journal of bioenergetics and biomembranes 1991;23(1):83-104.
1991: Yusuf A Hannun; Alfred H Merrill; R M Bell
Use of sphingosine as inhibitor of protein kinase C.
Methods in enzymology 1991;201():316-28.
1990: P Greenberg; Alfred H Merrill; Dennis C Liotta; G A Grabowski
Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site.
Biochimica et biophysica acta 1990;1039(1):12-20.
1990: Alfred H Merrill; D D Jones
An update of the enzymology and regulation of sphingomyelin metabolism.
Biochimica et biophysica acta 1990;1044(1):1-12.
1990: Y Yamada; Alfred H Merrill; Donald B McCormick
Probable reaction mechanisms of flavokinase and FAD synthetase from rat liver.
Archives of biochemistry and biophysics 1990;278(1):125-30.
1990: Victoria L Stevens; S Nimkar; W C Jamison; Dennis C Liotta; Alfred H Merrill
Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C.
Biochimica et biophysica acta 1990;1051(1):37-45.
1990: Victoria L Stevens; N E Owens; Elliott F Winton; J M Kinkade; Alfred H Merrill
Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.
Cancer research 1990;50(2):222-6.
1990: Alfred H Merrill; M Hoel; E Wang; R E Mullins; J L Hargrove; Dean P Jones; I A Popova
Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(1):95-100.
1990: Alfred H Merrill; J M Henderson
Vitamin B6 metabolism by human liver.
Annals of the New York Academy of Sciences 1990;585():110-7.
1989: C W Slife; Elaine Wang; R Hunter; S Wang; C Burgess; Dennis C Liotta; Alfred H Merrill
Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum.
The Journal of biological chemistry 1989;264(18):10371-7.
1989: Victoria L Stevens; Elliott F Winton; E E Smith; N E Owens; J M Kinkade; Alfred H Merrill
Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3.
Cancer research 1989;49(12):3229-34.
1989: Alfred H Merrill
Lipid modulators of cell function.
Nutrition reviews 1989;47(6):161-9.
1989: D G Robertson; M DiGirolamo; Alfred H Merrill; David J. Lambeth
Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.
The Journal of biological chemistry 1989;264(12):6773-9.
1989: Alfred H Merrill; S Nimkar; D Menaldino; Yusuf A Hannun; C Loomis; R M Bell; S R Tyagi; David J. Lambeth; Victoria L Stevens; R Hunter
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Biochemistry 1989;28(8):3138-45.
1989: J M Henderson; S S Scott; Alfred H Merrill; B Hollins; M H Kutner
Vitamin B6 repletion in cirrhosis with oral pyridoxine: failure to improve amino acid metabolism.
Hepatology (Baltimore, Md.) 1989;9(4):582-8.
1989: T O Messmer; Elaine Wang; Victoria L Stevens; Alfred H Merrill
Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins.
The Journal of nutrition 1989;119(4):534-8.
1989: Alfred H Merrill; Victoria L Stevens
Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction.
Biochimica et biophysica acta 1989;1010(2):131-9.
1989: B Enkvetchakul; Alfred H Merrill; Diane F Birt
Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate.
Carcinogenesis 1989;10(2):379-81.
1988: K A Medlock; Alfred H Merrill
Rapid turnover of sphingosine synthesized de novo from [14C]serine by Chinese hamster ovary cells.
Biochemical and biophysical research communications 1988;157(1):232-7.
1988: K A Medlock; Alfred H Merrill
Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine.
Biochemistry 1988;27(18):7079-84.
1988: E Wilson; Elaine Wang; R E Mullins; D J Uhlinger; Dennis C Liotta; David J. Lambeth; Alfred H Merrill
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
The Journal of biological chemistry 1988;263(19):9304-9.
1988: Alfred H Merrill; Elaine Wang; R E Mullins; W C Jamison; S Nimkar; Dennis C Liotta
Quantitation of free sphingosine in liver by high-performance liquid chromatography.
Analytical biochemistry 1988;171(2):373-81.
1988: Alfred H Merrill; Elaine Wang; R E Mullins
Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway.
Biochemistry 1988;27(1):340-5.
1988: H B White; Alfred H Merrill
Riboflavin-binding proteins.
Annual review of nutrition 1988;8():279-99.
1987: E Wilson; William G Rice; J M Kinkade; Alfred H Merrill; Roland R Arnold; David J. Lambeth
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
Archives of biochemistry and biophysics 1987;259(1):204-14.
1987: P R Girard; V L Stevens; Perry Blackshear; Alfred H Merrill; J G Wood; J F Kuo
Immunocytochemical evidence for phorbol ester-induced directional translocations of protein kinase C in HL60, K562, CHO, and E7SKS cells: possible role in differentiation.
Cancer research 1987;47(11):2892-8.
1987: Alfred H Merrill; E Wang; Dean P Jones; J L Hargrove
Hepatic function in rats after spaceflight: effects on lipids, glycogen, and enzymes.
The American journal of physiology 1987;252(2 Pt 2):R222-6.
1987: Alfred H Merrill; J M Henderson
Diseases associated with defects in vitamin B6 metabolism or utilization.
Annual review of nutrition 1987;7():137-56.
1986: Alfred H Merrill; J M Henderson; E Wang; M A Codner; B Hollins; W J Millikan
Activities of the hepatic enzymes of vitamin B6 metabolism for patients with cirrhosis.
The American journal of clinical nutrition 1986;44(4):461-7.
1986: Alfred H Merrill; A M Sereni; Victoria L Stevens; Yusuf A Hannun; R M Bell; J M Kinkade
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.
The Journal of biological chemistry 1986;261(27):12610-5.
1986: Yusuf A Hannun; C R Loomis; Alfred H Merrill; R M Bell
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.
The Journal of biological chemistry 1986;261(27):12604-9.
1986: E Wilson; M C Olcott; R M Bell; Alfred H Merrill; David J. Lambeth
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
The Journal of biological chemistry 1986;261(27):12616-23.
1986: Alfred H Merrill; E Wang; P W Wertz
Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777.
Lipids 1986;21(8):529-30.
1986: V L Stevens; David J. Lambeth; Alfred H Merrill
Use of cytochrome P-450scc to measure cholesterol-lipid interactions.
Biochemistry 1986;25(15):4287-92.
1986: J M Henderson; M A Codner; B Hollins; M H Kutner; Alfred H Merrill
The fasting B6 vitamer profile and response to a pyridoxine load in normal and cirrhotic subjects.
Hepatology (Baltimore, Md.) 1986;6(3):464-71.
1986: Alfred H Merrill; E Wang
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).
The Journal of biological chemistry 1986;261(8):3764-9.
1986: W S Innis; D W Nixon; Douglas R Murray; D B McCormick; Alfred H Merrill
Immunoglobulins associated with elevated riboflavin binding by plasma from cancer patients.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1986;181(2):237-41.
1986: Alfred H Merrill; E Wang
Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism.
Methods in enzymology 1986;122():110-6.
1985: Alfred H Merrill; E Wang; J L Hargrove
Hepatic enzymes of sphingolipid and glycerolipid biosynthesis in rats from Spacelab 3.
The Physiologist 1985;28(6 Suppl):S229.
1985: W S Innis; D B McCormick; Alfred H Merrill
Variations in riboflavin binding by human plasma: identification of immunoglobulins as the major proteins responsible.
Biochemical medicine 1985;34(2):151-65.
1985: Alfred H Merrill; D W Nixon; R D Williams
Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues.
Journal of lipid research 1985;26(5):617-22.
1985: Alfred H Merrill; E Wang; W S Innis; R Mullins
Increases in serum sphingomyelin by 17 beta-estradiol.
Lipids 1985;20(4):252-4.
1984: Alfred H Merrill; J M Henderson; E Wang; B W McDonald; W J Millikan
Metabolism of vitamin B-6 by human liver.
The Journal of nutrition 1984;114(9):1664-74.
1984: R D Williams; D W Nixon; Alfred H Merrill
Comparison of serine palmitoyltransferase in Morris hepatoma 7777 and rat liver.
Cancer research 1984;44(5):1918-23.
1984: Alfred H Merrill; E Wang; J Stevens; G W Brumley
Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen.
Biochemical and biophysical research communications 1984;119(3):995-1000.
1984: Alfred H Merrill; R D Williams
Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain.
Journal of lipid research 1984;25(2):185-8.
1984: R D Williams; E Wang; Alfred H Merrill
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.
Archives of biochemistry and biophysics 1984;228(1):282-91.
1983: Alfred H Merrill
Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells.
Biochimica et biophysica acta 1983;754(3):284-91.
1982: Alfred H Merrill; S Gidwitz; R M Bell
Facile enzymatic synthesis of fatty acylcoenzyme A thioesters.
Journal of lipid research 1982;23(9):1368-73.
1981: P R Green; Alfred H Merrill; R M Bell
Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase.
The Journal of biological chemistry 1981;256(21):11151-9.
1981: Alfred H Merrill; J A Froehlich; D B McCormick
Isolation and identification of alternative riboflavin-binding proteins from human plasma.
Biochemical medicine 1981;25(2):198-206.
1981: Alfred H Merrill; David J. Lambeth; Dale E Edmondson; D B McCormick
Formation and mode of action of flavoproteins.
Annual review of nutrition 1981;1():281-317.
1980: Alfred H Merrill; W Korytnyk; K Horiike; D B McCormick
Spectroscopic studies of complexes between pyridoxamine (pyridoxine)-5'-phosphate oxidase and pyridoxyl 5'-phosphate compounds differing at position 4'.
Biochimica et biophysica acta 1980;626(1):57-63.
1980: Alfred H Merrill; D B McCormick
Affinity chromatographic purification and properties of flavokinase (ATP:riboflavin 5'-phosphotransferase) from rat liver.
The Journal of biological chemistry 1980;255(4):1335-8.
1980: Alfred H Merrill; D B McCormick
Flavin affinity chromatography.
Methods in enzymology 1980;66():338-44.
1980: Alfred H Merrill; D B McCormick
Preparation of flavin 5'-phosphates using immobilized flavokinase.
Methods in enzymology 1980;66():287-90.
1979: Alfred H Merrill; J A Froehlich; D B McCormick
Purification of riboflavin-binding proteins from bovine plasma and discovery of a pregnancy-specific riboflavin-binding protein.
The Journal of biological chemistry 1979;254(19):9362-4.
1979: Alfred H Merrill; D B McCormick
Preparation and properties of immobilized flavokinase.
Biotechnology and bioengineering 1979;21(9):1629-38.
1979: Alfred H Merrill; S Kasai; K Matsui; H Tsuge; D B McCormick
Spectroscopic studies of pyridoxamine (pyridoxine) 5'-phosphate oxidase. Equilibrium dissociation constants and spectra for riboflavin 5'-phosphate and analogues.
Biochemistry 1979;18(16):3635-41.
1979: K Horiike; Alfred H Merrill; D B McCormick
Activation and inactivation of rabbit liver pyridoxamine (pyridoxine) 5'-phosphate oxidase activity by urea and other solutes.
Archives of biochemistry and biophysics 1979;195(2):325-35.
1979: Alfred H Merrill; M N Kazarinoff; H Tsuge; K Horiike; D B McCormick
Pyridoxamine (pyridoxine) 5'-phosphate oxidase from rabbit liver.
Methods in enzymology 1979;62():568-74.
1979: T C Campbell; J R Hayes; Alfred H Merrill; M Maso; M Goetchius
The influence of dietary factors on drug metabolism in animals.
Drug metabolism reviews 1979;9(2):173-84.
1978: J R Hayes; M U Mgbodile; Alfred H Merrill; L S Nerurkar; T C Campbell
The effect of dietary protein depletion and repletion on rat hepatic mixed function oxidase activities.
The Journal of nutrition 1978;108(11):1788-97.
1978: Alfred H Merrill; R Addison; D B McCormick
Induction of hepatic and intestinal flavokinase after oral administration of riboflavin to riboflavin-deficient rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1978;158(4):572-4.
1978: Alfred H Merrill; D B McCormick
Flavin affinity chromatography: general methods for purification of proteins that bind riboflavin.
Analytical biochemistry 1978;89(1):87-102.
1978: Alfred H Merrill; K Horiike; D B McCormick
Evidence for the regulation of pyridoxal 5-phosphate formation in liver by pyridoxamine (pyridoxine) 5 -phosphate oxidase.
Biochemical and biophysical research communications 1978;83(3):984-90.
1974: Alfred H Merrill; T C Campbell
Preliminary study of in vitro aflatoxin B 1 metabolism by human liver.
Toxicology and applied pharmacology 1974;27(1):210-3.