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Ethan Merritt

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Ratika Krishnamurty; Eric T Larson; Stephen E Leonard; Jennifer L Brigham; Edward J Dale; Ethan A Merritt; Pratistha Ranjitkar; Dustin J Maly
Active site profiling reveals coupling between domains in SRC-family kinases.
Pratistha Ranjitkar; Danielle L Swaney; Judit Villén; Daniel L Swaney; Sanjay B Hari; Ratika Krishnamurty; Eric T Larson; Ethan A Merritt; B Gayani K Perera; Dustin J Maly
Affinity-based probes based on type II kinase inhibitors.
Eric T Larson; Frederick S Buckner; Erkang Fan; Wim G J Hol; Jessica E Kim; Alberto J Napuli; Wesley C Van Voorhis; Christophe L M J Verlinde; Frank H Zucker; Ethan A Merritt
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.

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2013: Ratika Krishnamurty; Eric T Larson; Stephen E Leonard; Jennifer L Brigham; Edward J Dale; Ethan A Merritt; Pratistha Ranjitkar; Dustin J Maly
Active site profiling reveals coupling between domains in SRC-family kinases.
Nature chemical biology 2013;9(1):43-50.
2012: Pratistha Ranjitkar; Danielle L Swaney; Judit Villén; Daniel L Swaney; Sanjay B Hari; Ratika Krishnamurty; Eric T Larson; Ethan A Merritt; B Gayani K Perera; Dustin J Maly
Affinity-based probes based on type II kinase inhibitors.
Journal of the American Chemical Society 2012;134(46):19017-25.
2012: Eric T Larson; Frederick S Buckner; Erkang Fan; Wim G J Hol; Jessica E Kim; Alberto J Napuli; Wesley C Van Voorhis; Christophe L M J Verlinde; Frank H Zucker; Ethan A Merritt
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 9):1194-200.
2012: Zhongsheng Zhang; Alejandro Castellanos-Gonzalez; Jennifer A Geiger; Penqing He; Steven M Johnson; Eric T Larson; Dustin J Maly; Ethan A Merritt; Kayode K Ojo; Marilyn Parsons; Wesley C Van Voorhis; Christophe L M J Verlinde; A Clinton White; Erkang Fan
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Bioorganic & medicinal chemistry letters 2012;22(16):5264-7.
2012: Kayode K Ojo; Claudia Pfander; Molly C Reid; Christophe L M J Verlinde; Oliver Billker; Cassie M Bryan; Charlotte Burstroem; Anna M W Fox; Stephen N Hewitt; Steven M Johnson; Stefan Kappe; Mark Kennedy; Eric T Larson; David J Leibly; Dustin J Maly; Henning Mann; Ethan A Merritt; Natascha R Mueller; Ryan C Murphy; Wesley C Van Voorhis
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
The Journal of clinical investigation 2012;122(6):2301-5.
2012: Ethan A Merritt
To B or not to B: a question of resolution?
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 4):468-77.
2012: Eric T Larson; David J Leibly; Dustin J Maly; Ryan C Murphy; Kayode K Ojo; B Gayani K Perera; Molly C Reid; Wesley C Van Voorhis; Christophe L M J Verlinde; Zhongsheng Zhang; Edward J Dale; Erkang Fan; Anna M W Fox; Stephen N Hewitt; Wim G J Hol; Steven M Johnson; Jae Kim; Jessica E Kim; Ethan A Merritt
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
Journal of medicinal chemistry 2012;55(6):2803-10.
2012: Steven M Johnson; Eric T Larson; Edward J Dale; Amy E DeRocher; Erkang Fan; Anna M W Fox; Jennifer A Geiger; Panqing He; Ethan A Merritt; Natascha R Mueller; Ryan C Murphy; Kayode K Ojo; Marilyn Parsons; B Gayani K Perera; Molly C Reid; Wesley C Van Voorhis; Zhongsheng Zhang; Dustin J Maly
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Journal of medicinal chemistry 2012;55(5):2416-26.
2011: Ethan A Merritt
Some B(eq) are more equivalent than others.
Acta crystallographica. Section A, Foundations of crystallography 2011;67(Pt 6):512-6.
2011: Sayaka Shibata; Wesley C Van Voorhis; Christophe L M J Verlinde; Zhongsheng Zhang; Frank H Zucker; Wim G J Hol; Angela M Kelley; Konstantin Korotkov; Ethan A Merritt; Natasha Mueller; Alberto Napuli; Jennifer Ross; Frederick S Buckner; Jaclyn Delarosa; Erkang Fan
Screening a fragment cocktail library using ultrafiltration.
Analytical and bioanalytical chemistry 2011;401(5):1585-91.
2011: Eric T Larson; Jessica E Kim; Lisa J Castaneda; Alberto J Napuli; Zhongsheng Zhang; Erkang Fan; Frank H Zucker; Christophe L M J Verlinde; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.
Journal of molecular biology 2011;409(2):159-76.
2011: Sayaka Shibata; John R Gillespie; Angela M Kelley; Alberto J Napuli; Zhongsheng Zhang; Kuzma V Kovzun; Ranae M Pefley; Jocelyn Lam; Frank H Zucker; Wesley C Van Voorhis; Ethan A Merritt; Wim G J Hol; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Antimicrobial agents and chemotherapy 2011;55(5):1982-9.
2011: Ethan A Merritt; Tracy L Arakaki; Robert Gillespie; Alberto J Napuli; Jessica E Kim; Frederick S Buckner; Wesley C Van Voorhis; Christophe L M J Verlinde; Erkang Fan; Frank Zucker; Wim G J Hol
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.
Molecular and biochemical parasitology 2011;177(1):20-8.
2011: Kayode K Ojo; Tracy L Arakaki; Alberto J Napuli; Krishna K Inampudi; Katelyn R Keyloun; Li Zhang; Wim G J Hol; Christophe L M J Verlinde; Ethan A Merritt; Wesley C Van Voorhis
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.
Molecular and biochemical parasitology 2011;176(2):98-108.
2011: Eric T Larson; Jessica E Kim; Frank H Zucker; Angela Kelley; Natascha Mueller; Alberto J Napuli; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner; Wesley C Van Voorhis; Ethan A Merritt; Wim G J Hol
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie 2011;93(3):570-82.
2010: Frank Zucker; P Christoph Champ; Ethan A Merritt
Validation of crystallographic models containing TLS or other descriptions of anisotropy.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 8):889-900.
2010: Tracy L Arakaki; Megan Carter; Alberto J Napuli; Christophe L M J Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.
Journal of structural biology 2010;171(2):238-43.
2010: Frank H Zucker; Jaclyn dela Rosa; Tracy L Arakaki; Frederick S Buckner; Lisa J Castaneda; Erkang Fan; Jessica Kim; Eric T Larson; Ethan A Merritt; Natascha Mueller; Stephen R Nakazawa Hewitt; Alberto J Napuli; Jenni Ross; Christine Stewart; Easwara Subramanian; Wesley C Van Voorhis; Christophe L M J Verlinde; Liren Xiao; Li Zhang; Wim G J Hol
Prediction of protein crystallization outcome using a hybrid method.
Journal of structural biology 2010;171(1):64-73.
2010: Craig A Behnke; Isolde Le Trong; Jeff W Godden; Ethan A Merritt; David C Teller; Jürgen Bajorath; Ronald E Stenkamp
Atomic resolution studies of carbonic anhydrase II.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 5):616-27.
2010: Kayode K Ojo; Eric T Larson; Katelyn R Keyloun; Lisa J Castaneda; Amy E Derocher; Krishna K Inampudi; Jessica E Kim; Tracy L Arakaki; Ryan C Murphy; Li Zhang; Alberto J Napuli; Dustin J Maly; Christophe Verlinde; Frederick S Buckner; Marilyn Parsons; Wim G J Hol; Ethan A Merritt; Wesley C Van Voorhis
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nature structural & molecular biology 2010;17(5):602-7.
2010: Ethan A Merritt; Tracy L Arakaki; John R Gillespie; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Jessica Kim; Li Zhang; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Journal of molecular biology 2010;397(2):481-94.
2010: Eric T Larson; Devaraja G Mudeppa; John R Gillespie; Natascha Mueller; Alberto J Napuli; Jennifer A Arif; Jenni Ross; Tracy L Arakaki; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Christophe Verlinde; Erkang Fan; Wesley C Van Voorhis; Frederick S Buckner; Pradipsinh K Rathod; Wim G J Hol; Ethan A Merritt
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Journal of molecular biology 2010;396(5):1244-59.
2010: Ethan A Merritt; Tracy L Arakaki; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Li Zhang; George Deditta; Joseph Luft; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Molecular and biochemical parasitology 2010;169(2):95-100.
2009: Christophe L M J Verlinde; Erkang Fan; Sayaka Shibata; Zongsheng Zhang; Zhihua Sun; Wei Deng; Jennifer Ross; Jessica Kim; Liren Xiao; Tracy L Arakaki; Jürgen Bosch; Jonathan M Caruthers; Eric T Larson; Isolde Letrong; Alberto Napuli; Angela Kelly; Natasha Mueller; Frank Zucker; Wesley C Van Voorhis; Frederick S Buckner; Ethan A Merritt; Wim G J Hol
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.
Current topics in medicinal chemistry 2009;9(18):1678-87.
2008: Eric T Larson; Wei Deng; Brian Krumm; Alberto Napuli; Natascha Mueller; Wesley C Van Voorhis; Frederick S Buckner; Erkang Fan; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Wim G J Hol; Christophe Verlinde; Ethan A Merritt
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Journal of molecular biology 2008;381(4):975-88.
2008: Ethan A Merritt; Margaret Holmes; Frederick S Buckner; Wesley C Van Voorhis; Erin Quartly; Eric M Phizicky; Angela Lauricella; Joseph Luft; George deTitta; Helen Neely; Frank Zucker; Wim G J Hol
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):474-8.
2008: Tracy L Arakaki; Frederick S Buckner; John R Gillespie; Nicholas A Malmquist; Margaret A Phillips; Oleksandr Kalyuzhniy; Joseph Luft; George deTitta; Christophe Verlinde; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Molecular microbiology 2008;68(1):37-50.
2007: Gautam Dantas; Colin Corrent; Steve L Reichow; James J Havranek; Ziad M Eletr; Nancy G Isern; Brian Kuhlman; Gabriele Varani; Ethan A Merritt; David Baker
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.
Journal of molecular biology 2007;366(4):1209-21.
2007: Tracy Arakaki; Helen Neely; Erica Boni; Natasha Mueller; Frederick S Buckner; Wesley C Van Voorhis; Angela Lauricella; George deTitta; Joseph Luft; Wim G J Hol; Ethan A Merritt
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):178-82.
2006: Jürgen Bosch; Mark A Robien; Christopher Mehlin; Erica Boni; Aaron Riechers; Frederick S Buckner; Wesley C Van Voorhis; Peter J Myler; Elizabeth A Worthey; George deTitta; Joseph Luft; Angela Lauricella; Stacey Gulde; Lori A Anderson; Oleksandr Kalyuzhniy; Helen M Neely; Jenni Ross; Thomas N Earnest; Michael Soltis; Lori Schoenfeld; Frank Zucker; Ethan A Merritt; Erkang Fan; Christophe Verlinde; Wim G J Hol
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Journal of medicinal chemistry 2006;49(20):5939-46.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christophe Verlinde; Christopher Mehlin; Erica Boni; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Thomas N Earnest; Wim G J Hol; Ethan A Merritt
Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 5):427-31.
2006: Jay Painter; Ethan A Merritt
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 4):439-50.
2006: Mark A Robien; Jürgen Bosch; Frederick S Buckner; Wesley C Van Voorhis; Elizabeth A Worthey; Peter J Myler; Christopher Mehlin; Erica Boni; Oleksandr Kalyuzhniy; Lori Anderson; Angela Lauricella; Stacey Gulde; Joseph Luft; George deTitta; Jonathan M Caruthers; Keith O Hodgson; Michael Soltis; Frank Zucker; Christophe Verlinde; Ethan A Merritt; Lori W Schoenfeld; Wim G J Hol
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Proteins 2006;62(3):570-7.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christopher Mehlin; Erica Boni; Thomas N Earnest; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Wim G J Hol; Ethan A Merritt
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):180-5.
2006: Tracy Arakaki; Isolde Le Trong; Eric M Phizicky; Erin Quartley; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Elizabeth A Worthey; Peter J Myler; David Kim; David Baker; Wim G J Hol; Ethan A Merritt
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):175-9.
2006: David E Hyre; Isolde Le Trong; Ethan A Merritt; John F Eccleston; N Michael Green; Ronald E Stenkamp; Patrick S Stayton
Cooperative hydrogen bond interactions in the streptavidin-biotin system.
Protein science : a publication of the Protein Society 2006;15(3):459-67.
2005: Jonathan M Caruthers; Frank Zucker; Elizabeth A Worthey; Peter J Myler; Frederick S Buckner; Wes Van Voorhuis; Christopher Mehlin; Erica Boni; Tiffany Feist; Joseph Luft; Stacey Gulde; Angela Lauricella; Oleksandr Kaluzhniy; Lori Anderson; Isolde Le Trong; Margaret A Holmes; Thomas N Earnest; Michael Soltis; Keith O Hodgson; Wim G J Hol; Ethan A Merritt
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.
Protein science : a publication of the Protein Society 2005;14(11):2887-94.
2005: Jay Painter; Ethan A Merritt
A molecular viewer for the analysis of TLS rigid-body motion in macromolecules.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 4):465-71.
2004: Erkang Fan; Claire J O'Neal; Daniel D Mitchell; Mark A Robien; Zhongsheng Zhang; Jason Pickens; Xiao-Jian Tan; Konstantin Korotkov; Claudia Roach; Brian Krumm; Christophe Verlinde; Ethan A Merritt; Wim G J Hol
Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.
International journal of medical microbiology : IJMM 2004;294(4):217-23.
2002: Zhongsheng Zhang; Ethan A Merritt; Misol Ahn; Claudia Roach; Zheng Hou; Christophe Verlinde; Wim G J Hol; Erkang Fan
Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.
Journal of the American Chemical Society 2002;124(44):12991-8.
2002: Ethan A Merritt; Zhongsheng Zhang; Jason Pickens; Misol Ahn; Wim G J Hol; Erkang Fan
Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.
Journal of the American Chemical Society 2002;124(30):8818-24.
2002: Erkang Fan; Ethan A Merritt
Combating infectious diseases through multivalent design.
Current drug targets. Infectious disorders 2002;2(2):161-7.
2002: Timothy R Hirst; Sylvia Fraser; Marco Soriani; A Tholib Aman; Haan Lolke de; Arron R Hearn; Ethan A Merritt
New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins.
International journal of medical microbiology : IJMM 2002;291(6-7):531-5.
2002: Jason Pickens; Ethan A Merritt; Misol Ahn; Christophe Verlinde; Wim G J Hol; Erkang Fan
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chemistry & biology 2002;9(2):215-24.
2001: A Tholib Aman; S Fraser; Ethan A Merritt; C Rodigherio; M Kenny; Misol Ahn; Wim G J Hol; Neil A Williams; Wayne I Lencer; Timothy R Hirst
A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8536-41.
2001: Erkang Fan; Ethan A Merritt; Zhongsheng Zhang; Jason Pickens; Claudia Roach; Misol Ahn; Wim G J Hol
Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):201-12.
2000: Erkang Fan; Ethan A Merritt; Christophe Verlinde; Wim G J Hol
AB(5) toxins: structures and inhibitor design.
Current opinion in structural biology 2000;10(6):680-6.
2000: WE Minke; Jason Pickens; Ethan A Merritt; Erkang Fan; Christophe Verlinde; Wim G J Hol
Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):795-804.
1999: Ethan A Merritt
Comparing anisotropic displacement parameters in protein structures.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 12):1997-2004.
1999: Ethan A Merritt
Expanding the model: anisotropic displacement parameters in protein structure refinement.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 6):1109-17.
1999: B T Hovey; Christophe Verlinde; Ethan A Merritt; Wim G J Hol
Structure-based discovery of a pore-binding ligand: towards assembly inhibitors for cholera and related AB5 toxins.
Journal of molecular biology 1999;285(3):1169-78.
1998: IK Feil; A A Platas; Focco Van Den Akker; R Reddy; Ethan A Merritt; D R Storm; Wim G J Hol
Stepwise transplantation of an active site loop between heat-labile enterotoxins LT-II and LT-I and characterization of the obtained hybrid toxins.
Protein engineering 1998;11(11):1103-9.
1998: Ethan A Merritt; P Kuhn; S Sarfaty; Jarrod L Erbe; Randall K Holmes; Wim G J Hol
The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site.
Journal of molecular biology 1998;282(5):1043-59.
1997: Focco Van Den Akker; IK Feil; Claudia Roach; A A Platas; Ethan A Merritt; Wim G J Hol
Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit.
Protein science : a publication of the Protein Society 1997;6(12):2644-9.
1997: Ethan A Merritt; S Sarfaty; IK Feil; Wim G J Hol
Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure (London, England : 1993) 1997;5(11):1485-99.
1997: Ethan A Merritt; S Sarfaty; Michael G Jobling; T Chang; Randall K Holmes; Timothy R Hirst; Wim G J Hol
Structural studies of receptor binding by cholera toxin mutants.
Protein science : a publication of the Protein Society 1997;6(7):1516-28.
1996: J Mitchell Guss; Ethan A Merritt; R P Phizackerley; Hans C Freeman
The structure of a phytocyanin, the basic blue protein from cucumber, refined at 1.8 A resolution.
Journal of molecular biology 1996;262(5):686-705.
1996: I K Feil; R Reddy; L de Haan; Ethan A Merritt; Focco Van Den Akker; D R Storm; Wim G J Hol
Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity.
Molecular microbiology 1996;20(4):823-32.
1995: Focco Van Den Akker; Ethan A Merritt; M Pizza; M Domenighini; R Rappuoli; Wim G J Hol
The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry 1995;34(35):10996-1004.
1995: Ethan A Merritt; S Sarfaty; T T Chang; L M Palmer; Michael G Jobling; Randall K Holmes; Wim G J Hol
Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure (London, England : 1993) 1995;3(6):561-70.
1995: Ethan A Merritt; S Sarfaty; M Pizza; M Domenighini; R Rappuoli; Wim G J Hol
Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nature structural biology 1995;2(4):269-72.
1995: Ethan A Merritt; Wim G J Hol
AB5 toxins.
Current opinion in structural biology 1995;5(2):165-71.
1994: Ethan A Merritt; M E Murphy
Raster3D Version 2.0. A program for photorealistic molecular graphics.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 6):869-73.
1994: Christophe Verlinde; Ethan A Merritt; Focco Van Den Akker; H Kim; I Feil; L F Delboni; S C Mande; S Sarfaty; P H Petra; Wim G J Hol
Protein crystallography and infectious diseases.
Protein science : a publication of the Protein Society 1994;3(10):1670-86.
1994: Ethan A Merritt; T K Sixma; Kor H Kalk; B A van Zanten; Wim G J Hol
Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Molecular microbiology 1994;13(4):745-53.
1994: Ethan A Merritt; S Sarfaty; Focco Van Den Akker; C L'Hoir; Joseph A Martial; Wim G J Hol
Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide.
Protein science : a publication of the Protein Society 1994;3(2):166-75.
1994: Ethan A Merritt; S E Pronk; T K Sixma; Kor H Kalk; B A van Zanten; Wim G J Hol
Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution.
FEBS letters 1994;337(1):88-92.
1993: Ethan A Merritt; G H Stout; S Turley; Larry Sieker; L H Jehsen; W H Orme-Johnson
Structure at pH 6.5 of ferredoxin I from Azotobacter vinelandii at 2.3 A resolution.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 2):272-81.
1992: P R Kolatkar; SR Ernst; Marvin L Hackert; C M Ogata; Wayne A Hendrickson; Ethan A Merritt; R P Phizackerley
Structure determination and refinement of homotetrameric hemoglobin from Urechis caupo at 2.5 A resolution.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 2)():191-9.
1989: Wayne A Hendrickson; A Pähler; J L Smith; Y Satow; Ethan A Merritt; R P Phizackerley
Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2190-4.
1988: H M Murthy; Wayne A Hendrickson; W H Orme-Johnson; Ethan A Merritt; R P Phizackerley
Crystal structure of Clostridium acidi-urici ferredoxin at 5-A resolution based on measurements of anomalous X-ray scattering at multiple wavelengths.
The Journal of biological chemistry 1988;263(34):18430-6.
1988: J Mitchell Guss; Ethan A Merritt; R P Phizackerley; Britt Hedman; M Murata; Keith O Hodgson; Hans C Freeman
Phase determination by multiple-wavelength x-ray diffraction: crystal structure of a basic "blue" copper protein from cucumbers.
Science (New York, N.Y.) 1988;241(4867):806-11.
1988: Wayne A Hendrickson; J L Smith; R P Phizackerley; Ethan A Merritt
Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation.
Proteins 1988;4(2):77-88.