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Angel Messeguer

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Chemicals & Drugs

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Vicente Andreu-Fernández; Ainhoa Genovés; Angel Messeguer; Mar Orzáez; Mónica Sancho; Enrique Perez-Paya
BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.
Alvaro C Ucero; María J Vicent; Marta Ruiz-Ortega; Mónica Sancho; Sergio Berzal; Jesús Egido; Angel Messeguer; Carlos Ocaña-Salceda; Alberto Ortiz; Mar Orzáez; Adrián M Ramos
A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
Alejandra Moure; Mar Orzáez; Mónica Sancho; Angel Messeguer
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.

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All Publications

2013: Vicente Andreu-Fernández; Ainhoa Genovés; Angel Messeguer; Mar Orzáez; Mónica Sancho; Enrique Perez-Paya
BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.
PloS one 2013;8(2):e56881.
2013: Alvaro C Ucero; María J Vicent; Marta Ruiz-Ortega; Mónica Sancho; Sergio Berzal; Jesús Egido; Angel Messeguer; Carlos Ocaña-Salceda; Alberto Ortiz; Mar Orzáez; Adrián M Ramos
A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
PloS one 2013;8(1):e51992.
2012: Alejandra Moure; Mar Orzáez; Mónica Sancho; Angel Messeguer
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(23):7097-9.
2012: Antonio Ferrer-Montiel; Gregorio Fernández-Ballester; Asia Fernández-Carvajal; José M González-Ros; Angel Messeguer; Rosa Planells-Cases; Rosario González-Muñiz
Advances in modulating thermosensory TRP channels.
Expert opinion on therapeutic patents 2012;22(9):999-1017.
2011: Miquel Vidal-Mosquera; Alejandra Moure; Rosa Planells-Cases; Pierluigi Valente; Jordi Bujons; Asia Fernández-Carvajal; Antonio Ferrer-Montiel; José M González-Ros; Angel Messeguer
Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.
Journal of medicinal chemistry 2011;54(21):7441-52.
2011: Alejandra Moure; Enrique Perez-Paya; Glòria Sanclimens; Ignacio Alfonso; Angel Alvarez-Larena; Jordi Bujons; Isabel Masip; Angel Messeguer
Chemical modulation of peptoids: synthesis and conformational studies on partially constrained derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(28):7927-39.
2011: Caitriona M O'Driscoll; Nuria Sanvicens; Francesca Doonan; Angel Messeguer; Thomas G Cotter
A novel free radical scavenger rescues retinal cells in vivo.
Experimental eye research 2011;93(1):65-74.
2011: Enrique Perez-Paya; Angel Messeguer; Laura Mondragón; Mar Orzáez; James A Wells; Dennis Wolan; María J Vicent
Molecules that modulate Apaf-1 activity.
Medicinal research reviews 2011;31(4):649-75.
2011: Angel Messeguer
Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS).
Chemico-biological interactions 2011;192(1-2):136-41.
2010: María J Vicent; Laura Cascales; Rodrigo J Carbajo; Nuria Cortés; Angel Messeguer; Enrique Perez-Paya
Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):277-85.
2010: Fernando J Pérez-Asensio; Xavier de la Rosa; Francesc Jiménez-Altayó; Roser Gorina; Emili Martínez; Angel Messeguer; Elisabet Vila; Angel Chamorro; Anna M Planas
Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(3):638-52.
2010: M Carme Mulero; Mar Orzáez; Joaquim Messeguer; Angel Messeguer; Enrique Perez-Paya; Mercè Pérez-Riba
A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex.
Analytical biochemistry 2010;398(1):99-103.
2009: Francesc Jiménez-Altayó; Laura Caracuel; Fernando J Pérez-Asensio; Sonia Martínez-Revelles; Angel Messeguer; Anna M Planas; Elisabet Vila
Participation of oxidative stress on rat middle cerebral artery changes induced by focal cerebral ischemia: beneficial effects of 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6).
The Journal of pharmacology and experimental therapeutics 2009;331(2):429-36.
2009: Marta Montolio; Joaquim Messeguer; Isabel Masip; Patricia Guijarro; Rosalina Gavin; José Antonio Del Río; Angel Messeguer; Eduardo Soriano
A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration.
Chemistry & biology 2009;16(7):691-701.
2009: Ma Carme Mulero; Anna Aubareda; Mar Orzáez; Joaquim Messeguer; Eva Serrano-Candelas; Sergio Martínez-Hoyer; Angel Messeguer; Enrique Perez-Paya; Mercè Pérez-Riba
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity.
The Journal of biological chemistry 2009;284(14):9394-401.
2009: Laura Mondragón; Lorenzo Galluzzi; Shahul Mouhamad; Mar Orzáez; José-Miguel Vicencio; Ilio Vitale; Alejandra Moure; Angel Messeguer; Enrique Perez-Paya; Guido Kroemer
A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.
Apoptosis : an international journal on programmed cell death 2009;14(2):182-90.
2008: Joaquim Messeguer; Nuria Cortés; Nuria García-Sanz; Gloria Navarro-Vendrell; Antonio Ferrer-Montiel; Angel Messeguer
Synthesis of a positional scanning library of pentamers of N-alkylglycines assisted by microwave activation and validation via the identification of trypsin inhibitors.
Journal of combinatorial chemistry 2008;10(6):974-80.
2008: Elvira Valera; Francisco J Sánchez-Martín; Antonio Ferrer-Montiel; Angel Messeguer; Jaime M Merino
NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.
Neurochemistry international 2008;53(5):148-54.
2008: L Mondragón; Mar Orzáez; Glòria Sanclimens; A Moure; A Armiñán; Pilar Sepulveda; Angel Messeguer; María J Vicent; Enrique Perez-Paya
Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors.
Journal of medicinal chemistry 2008;51(3):521-9.
2007: María Miranda; María Muriach; Inmaculada Almansa; Emma Arnal; Angel Messeguer; Manuel Díaz-Llopis; Francisco J Romero; Francisco Bosch-Morell
CR-6 protects glutathione peroxidase activity in experimental diabetes.
Free radical biology & medicine 2007;43(11):1494-8.
2007: Anna Martínez-Cabot; Angel Messeguer
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome.
Chemical research in toxicology 2007;20(10):1556-62.
2007: Roser Gorina; Coral Sanfeliu; Aida Galitó; Angel Messeguer; Anna M Planas
Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.
Glia 2007;55(13):1313-24.
2007: Anna Martínez-Cabot; Anna Morató; Jan N M Commandeur; Nico P E Vermeulen; Angel Messeguer
In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome.
Chemical research in toxicology 2007;20(8):1218-24.
2007: María Miranda; Francisco Bosch-Morell; Siv Johnsen-Soriano; Juan A Barcia; Inmaculada Almansa; Samuel Asensio; Javier Araiz; Angel Messeguer; Francisco J Romero
Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.
Neurochemical research 2007;32(7):1156-62.
2007: Carlos Mas-Moruno; Luis J Cruz; Puig Mora; Andrés Francesch; Angel Messeguer; Enrique Pérez-Paya; Fernando Albericio
Smallest peptoids with antiproliferative activity on human neoplastic cells.
Journal of medicinal chemistry 2007;50(10):2443-9.
2007: Mar Orzáez; Laura Mondragón; Isabel Marzo; Glòria Sanclimens; Angel Messeguer; Enrique Perez-Paya; María J Vicent
Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis.
Peptides 2007;28(5):958-68.
2007: Natalia Reig; Rosa E Calaf; Angel Messeguer; Anna Morató; Jordi Escabros; Emilio Gelpí; Joaquin Abian
LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil.
Journal of mass spectrometry : JMS 2007;42(4):527-41.
2007: Angel Messeguer; Nuria Cortés
Combinatorial chemistry in cancer research.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2007;9(2):83-92.
2006: G Malet; A G Martín; Mar Orzáez; María J Vicent; Isabel Masip; Glòria Sanclimens; Antonio Ferrer-Montiel; Ismael Mingarro; Angel Messeguer; Howard Fearnhead; Enrique Perez-Paya
Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.
Cell death and differentiation 2006;13(9):1523-32.
2006: Nuria Sanvicens; Violeta Gómez-Vicente; Angel Messeguer; Thomas G Cotter
The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways.
Journal of neurochemistry 2006;98(3):735-47.
2006: Nieves Márquez; Rocío Sancho; Antonio Macho; Alejandra Moure; Isabel Masip; Angel Messeguer; Eduardo Muñoz
Anti-Tat and anti-HIV activities of trimers of n-alkylglycines.
Biochemical pharmacology 2006;71(5):596-604.
2006: Angel Messeguer; Rosa Planells-Cases; Antonio Ferrer-Montiel
Physiology and pharmacology of the vanilloid receptor.
Current neuropharmacology 2006;4(1):1-15.
2005: Soledad Gallardo; Blanca Cárdaba; Manuel Posada; VICTORIA DEL POZO; Angel Messeguer; Chella S David; Carlos Lahoz
Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice.
Toxicology letters 2005;159(2):173-81.
2005: Anna Martínez-Cabot; Anna Morató; Angel Messeguer
Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome.
Chemical research in toxicology 2005;18(11):1721-8.
2005: Isabel Masip; Enrique Perez-Paya; Angel Messeguer
Peptoids as source of compounds eliciting antibacterial activity.
Combinatorial chemistry & high throughput screening 2005;8(3):235-9.
2005: Anna Morató; Jordi Escabrós; Albert Manich; Natàlia Reig; Yolanda Castaño; Joaquín Abián; Angel Messeguer
On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome.
Chemical research in toxicology 2005;18(4):665-74.
2005: Maria J Abad-Merin; Nuria Cortés; Isabel Masip; Enrique Perez-Paya; José A Ferragut; Angel Messeguer; Antonio Ferrer-Montiel
Trimers of N-alkylglycines are potent modulators of the multidrug resistance phenotype.
The Journal of pharmacology and experimental therapeutics 2005;313(1):112-20.
2005: Isabel Masip; Nuria Cortés; Maria-José Abad; Marisa Guardiola; Enrique Perez-Paya; José A Ferragut; Antonio Ferrer-Montiel; Angel Messeguer
Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents.
Bioorganic & medicinal chemistry 2005;13(6):1923-9.
2005: Puig Mora; Isabel Masip; Nuria Cortés; Regina Marquina; Ramón Merino; Jesús Merino; Teresa Carbonell; Ismael Mingarro; Angel Messeguer; Enrique Perez-Paya
Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins.
Journal of medicinal chemistry 2005;48(4):1265-8.
2004: Nuria Sanvicens; Violeta Gómez-Vicente; Isabel Masip; Angel Messeguer; Thomas G Cotter
Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.
The Journal of biological chemistry 2004;279(38):39268-78.
2004: Susana Yenes; Jan N M Commandeur; Nico P E Vermeulen; Angel Messeguer
In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes.
Chemical research in toxicology 2004;17(7):904-13.
2004: Anna Morató; Anna Martínez-Cabot; Jordi Escabrós; Jordi Bujons; Angel Messeguer
Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase.
Chemical research in toxicology 2004;17(7):889-95.
2004: Isabel Masip; Clotilde Ferrándiz-Huertas; Carolina García-Martínez; José A Ferragut; Antonio Ferrer-Montiel; Angel Messeguer
Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds.
Journal of combinatorial chemistry 2004;6(1):135-41.
2003: Rosa Planells-Cases; Enrique Perez-Paya; Angel Messeguer; Cristina Carreño; Antonio Ferrer-Montiel
Small molecules targeting the NMDA receptor complex as drugs for neuropathic pain.
Mini reviews in medicinal chemistry 2003;3(7):749-56.
2003: Marc Humet; Teresa Carbonell; Isabel Masip; Francisco Sánchez-Baeza; Puig Mora; Emilia Cantón; Miguel Gobernado; Concepción Abad; Enrique Perez-Paya; Angel Messeguer
A positional scanning combinatorial library of peptoids as a source of biological active molecules: identification of antimicrobials.
Journal of combinatorial chemistry 2003;5(5):597-605.
2003: Carmen Vale; Elena Fonfría; Jordi Bujons; Angel Messeguer; Eduard Rodríguez-Farré; Cristina Suñol
The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells.
Neuroscience 2003;117(2):397-403.
2002: Rosa Planells-Cases; Carmina Montoliu; Marc Humet; Asia M Fernández; Carolina García-Martínez; Elvira Valera; Jaime M Merino; Enrique Perez-Paya; Angel Messeguer; Vicente Felipo; Antonio Ferrer-Montiel
A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity.
The Journal of pharmacology and experimental therapeutics 2002;302(1):163-73.
2002: Carmina Montoliu; Marc Humet; Juan-José Canales; Jozef Burda; Rosa Planells-Cases; Francisco Sánchez-Baeza; Teresa Carbonell; Enrique Perez-Paya; Angel Messeguer; Antonio Ferrer-Montiel; Vicente Felipo
Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.
The Journal of pharmacology and experimental therapeutics 2002;301(1):29-36.
2002: Carolina García-Martinez; Marc Humet; Rosa Planells-Cases; Ana Gomis; Marco Caprini; Felix Viana; Elvira De La Pena; Francisco Sanchez-Baeza; Teresa Carbonell; Carmen De Felipe; Enrique Pérez-Paya; carlos belmonte; Angel Messeguer; Antonio Ferrer-Montiel
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2374-9.
2002: Elvira Valera; Pedro M Fernández-Salguero; Rosa Planells-Cases; Angel Messeguer; Wim Van Den Nest; Cristina Carreño; Antonio Ferrer-Montiel; Jaime M Merino
Neuroprotection against excitotoxicity by N-alkylglycines in rat hippocampal neurons.
Neuromolecular medicine 2002;2(3):271-80.
2001: Jordi Bujons; MG Ladona; Angel Messeguer; Anna Morató; Coral Ampurdanés
Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.
Chemical research in toxicology 2001;14(8):1097-106.
2001: MG Ladona; Jordi Bujons; Angel Messeguer; Coral Ampurdanés; Anna Morató
Metabolism of R,S enantiomers of 3-phenylamino-1,2-propanediol, a compound associated with the toxic oil syndrome, in C57BL/6- and A/J-strain mice.
Advances in experimental medicine and biology 2001;500():525-9.
2000: Teresa Carbonell; Isabel Masip; Francisco Sánchez-Baeza; M Delgado; E Araya; Oriol Llorens; Francesc J Corcho; Juan Jesús Pérez; Enrique Perez-Paya; Angel Messeguer
Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones.
Molecular diversity 2000;5(3):131-43.
1999: MG Ladona; Jordi Bujons; Angel Messeguer; Coral Ampurdanés; Anna Morató; J Corbella
Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice.
Chemical research in toxicology 1999;12(12):1127-37.
1999: Carmina Montoliu; Marta Llansola; R Sáez; S Yenes; Angel Messeguer; Vicente Felipo
Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide.
Biochemical pharmacology 1999;58(2):255-61.