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Donald Metcalf

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Jian Zhong Tang; Zhizhuang Joe Zhao; Catherine L Carmichael; Neal G Copeland; Viive M Howell; Craig D Hyland; Nancy A Jenkins; Benjamin T Kile; Donald Metcalf; Ashley Ng; Wei Shi; Gordon K Smyth; Warren S Alexander
Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Seth L Masters; Kate McArthur; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Marc Pellegrini; Simon Preston; Warren S Alexander; Tracey M Baldwin; Louise H Cengia; Stephane Chevrier; Janelle E Collinge; Lionel Feigenbaum; Motti Gerlic; Katya J Henley; Douglas J Hilton; Daniel L Kastner; Benjamin T Kile; Ben A Croker
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Marlyse A Debrincat; Sarah Ellis; Natasha L Harvey; Katya J Henley; Chloé James; Emma C Josefsson; Rachael M Lane; Marion Lebois; Donald Metcalf; Andrew W Roberts; Kelly L Rogers; Michael J White; Kelly L Betterman; Benjamin T Kile
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.

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2013: Jian Zhong Tang; Zhizhuang Joe Zhao; Catherine L Carmichael; Neal G Copeland; Viive M Howell; Craig D Hyland; Nancy A Jenkins; Benjamin T Kile; Donald Metcalf; Ashley Ng; Wei Shi; Gordon K Smyth; Warren S Alexander
Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6091-6.
2012: Seth L Masters; Kate McArthur; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Marc Pellegrini; Simon Preston; Warren S Alexander; Tracey M Baldwin; Louise H Cengia; Stephane Chevrier; Janelle E Collinge; Lionel Feigenbaum; Motti Gerlic; Katya J Henley; Douglas J Hilton; Daniel L Kastner; Benjamin T Kile; Ben A Croker
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Immunity 2012;37(6):1009-23.
2012: Marlyse A Debrincat; Sarah Ellis; Natasha L Harvey; Katya J Henley; Chloé James; Emma C Josefsson; Rachael M Lane; Marion Lebois; Donald Metcalf; Andrew W Roberts; Kelly L Rogers; Michael J White; Kelly L Betterman; Benjamin T Kile
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Blood 2012;119(24):5850-8.
2012: Ashley Ng; Ladina Di Rago; Craig D Hyland; Maria Kauppi; Donald Metcalf; Warren S Alexander
Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2364-9.
2011: Emma C Josefsson; Marlyse A Debrincat; Mark R Dowling; Sarah Ellis; Katya J Henley; David C S Huang; Chloé James; Elizabeth A Kruse; Rachael M Lane; Kylie D Mason; Donald Metcalf; Paquita Nurden; Lorraine A O'Reilly; Andrew W Roberts; Kelly L Rogers; Michael J White; Benjamin T Kile
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
The Journal of experimental medicine 2011;208(10):2017-31.
2011: Ashley Ng; Gordon K Smyth; Carolyn A de Graaf; Douglas J Hilton; Yifang Hu; Craig D Hyland; Benjamin T Kile; Stephen J Loughran; Donald Metcalf; Warren S Alexander
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.
Blood 2011;118(9):2454-61.
2011: Ben A Croker; Grant Dewson; Yifang Hu; Kurt Lackovic; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Lorraine A O'Reilly; Philippe Bouillet; Kirsteen J Campbell; Louise H Cengia; Suzanne Cory; Kelly L Rogers; Gordon K Smyth; Andreas Strasser; Michael White; Jian-Guo Zhang; Andrew W Roberts
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13135-40.
2011: Ben A Croker; Rowena S Lewis; Jeff J Babon; Justine D Mintern; Dieter E Jenne; Donald Metcalf; Jian-Guo Zhang; Louise H Cengia; Joanne A O'Donnell; Andrew W Roberts
Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1131-9.
2010: Kirsteen J Campbell; Mary L Bath; Marian L Turner; Cassandra J Vandenberg; Philippe Bouillet; Donald Metcalf; Clare L Scott; Suzanne Cory
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.
Blood 2010;116(17):3197-207.
2010: Donald Metcalf; Ashley Ng; Sandra Mifsud; Ladina Di Rago
Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16257-61.
2010: Ashley Ng; Craig D Hyland; Donald Metcalf; Catherine L Carmichael; Stephen J Loughran; Ladina Di Rago; Benjamin T Kile; Warren S Alexander
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome.
Blood 2010;115(19):3966-9.
2010: James M Murphy; Donald Metcalf; Ian G Young; Douglas J Hilton
A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.
Growth factors (Chur, Switzerland) 2010;28(2):104-10.
2009: Donald Metcalf; Ashley Ng; Stephen J L Loughran; Belinda Phipson; Gordon K Smyth; Ladina Di Rago; Sandra Mifsud
Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):19102-7.
2009: Elizabeth A Kruse; Stephen J Loughran; Tracey M Baldwin; Emma C Josefsson; Sarah Ellis; Dennis Watson; Paquita Nurden; Donald Metcalf; Douglas J Hilton; Warren S Alexander; Benjamin T Kile
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13814-9.
2009: Kathy D'Costa; Dianne Emslie; Donald Metcalf; Gordon K Smyth; Alexander Karnowski; Axel Kallies; Stephen L Nutt; Lynn M Corcoran
Blimp1 is limiting for transformation in a mouse plasmacytoma model.
Blood 2009;113(23):5911-9.
2008: Jo L Eyles; Michael J Hickey; M Ursula Norman; Ben A Croker; Andrew W Roberts; Sarah F Drake; Will G James; Donald Metcalf; Ian K Campbell; Ian P Wicks
A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis.
Blood 2008;112(13):5193-201.
2008: Donald Metcalf; K T Greig; C A de Graaf; S J Loughran; Warren S Alexander; M Kauppi; Craig D Hyland; Ladina Di Rago; Sandra Mifsud
Two distinct types of murine blast colony-forming cells are multipotential hematopoietic precursors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18501-6.
2008: Stephen J Loughran; Elizabeth A Kruse; Douglas F Hacking; Carolyn A de Graaf; Craig D Hyland; Tracy A Willson; Katya J Henley; Sarah Ellis; Anne K Voss; Donald Metcalf; Douglas J Hilton; Warren S Alexander; Benjamin T Kile
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
Nature immunology 2008;9(7):810-9.
2008: Ben A Croker; Lisa A Mielke; Samuel Wormald; Donald Metcalf; Hiu Kiu; Warren S Alexander; Douglas J Hilton; Andrew W Roberts
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
Experimental hematology 2008;36(7):786-98.
2008: Ian J Majewski; Marnie E Blewitt; Carolyn A de Graaf; Edward J McManus; Melanie Bahlo; Adrienne A Hilton; Craig D Hyland; Gordon K Smyth; Jason E Corbin; Donald Metcalf; Warren S Alexander; Douglas J Hilton
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
PLoS biology 2008;6(4):e93.
2008: Dianne Emslie; Kathy D'Costa; Jhagvaral Hasbold; Donald Metcalf; Kiyoshi Takatsu; Philip O Hodgkin; Lynn M Corcoran
Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.
The Journal of experimental medicine 2008;205(2):409-21.
2008: Donald Metcalf
Hematopoietic cytokines.
Blood 2008;111(2):485-91.
2007: Donald Metcalf; Stefan Glaser; Sandra Mifsud; Ladina Di Rago; Lorraine Robb
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):20013-8.
2007: Christine A White; Jian-Guo Zhang; Lois salamonsen; Manuel Baca; W Douglas Fairlie; Donald Metcalf; Nicos A Nicola; Lorraine Robb; Evdokia Dimitriadis
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19357-62.
2007: Elena Tucker; Kristy O'Donnell; Martina Fuchsberger; Adrienne A Hilton; Donald Metcalf; Kylie Greig; Natalie Sims; Julian M W Quinn; Warren S Alexander; Douglas J Hilton; Benjamin T Kile; David M Tarlinton; Robyn Starr
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7514-22.
2007: Donald Metcalf; Ian Majewski; Sandra Mifsud; Ladina Di Rago; Warren S Alexander
Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18642-7.
2007: Shalin Naik; Priyanka Sathe; Hae-Young Park; Donald Metcalf; Anna I Proietto; Aleksander Dakic; Sebastian Carotta; Meredith O'Keeffe; Melanie Bahlo; Anthony Papenfuss; Jong-Young Kwak; Li Wu; Ken Shortman
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo.
Nature immunology 2007;8(11):1217-26.
2007: Donald Metcalf
Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions.
Stem cells (Dayton, Ohio) 2007;25(10):2390-5.
2007: Kristy Boyle; Paul J Egan; Steven Rakar; Tracy A Willson; Ian P Wicks; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts; Lorraine Robb
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
Blood 2007;110(5):1466-74.
2007: Kylie T Greig; Jennifer Antonchuk; Donald Metcalf; Phillip O Morgan; Danielle L Krebs; Jian-Guo Zhang; Douglas F Hacking; Lars Bode; Lorraine Robb; Christian Kranz; Carolyn de Graaf; Melanie Bahlo; Nicos A Nicola; Stephen L Nutt; Hudson H Freeze; Warren S Alexander; Douglas J Hilton; Benjamin T Kile
Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development.
Molecular and cellular biology 2007;27(16):5849-59.
2007: Donald Metcalf
On hematopoietic stem cell fate.
Immunity 2007;26(6):669-73.
2007: Kylie D Mason; Marina R Carpinelli; Jamie I Fletcher; Janelle E Collinge; Adrienne A Hilton; Sarah Ellis; Priscilla N Kelly; Paul G Ekert; Donald Metcalf; Andrew W Roberts; David C S Huang; Benjamin T Kile
Programmed anuclear cell death delimits platelet life span.
Cell 2007;128(6):1173-86.
2006: Warren S Alexander; Elizabeth M Viney; Jian-Guo Zhang; Donald Metcalf; Maria Kauppi; Craig D Hyland; Marina R Carpinelli; William Stevenson; Ben A Croker; Adrienne A Hilton; Sarah Ellis; Carly Selan; Harshal H Nandurkar; Christopher C Goodnow; Benjamin T Kile; Nicos A Nicola; Andrew W Roberts; Douglas J Hilton
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16442-7.
2006: Stefan Glaser; Donald Metcalf; Li Wu; Adam H Hart; Ladina DiRago; Sandra Mifsud; Angela D'Amico; Samantha Dagger; Chiara Campo; Angela Chan; David J Izon; Lorraine Robb
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16460-5.
2006: Ian J Majewski; Donald Metcalf; Lisa A Mielke; Danielle L Krebs; Sarah Ellis; Marina R Carpinelli; Sandra Mifsud; Ladina Di Rago; Jason Corbin; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14146-51.
2006: Darrin P Smith; Mary L Bath; Donald Metcalf; Alan W Harris; Suzanne Cory
MYC levels govern hematopoietic tumor type and latency in transgenic mice.
Blood 2006;108(2):653-61.
2006: Shalin Naik; Donald Metcalf; Annemarie van Nieuwenhuijze; Ian P Wicks; Li Wu; Meredith O'Keeffe; Ken Shortman
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes.
Nature immunology 2006;7(6):663-71.
2006: Tim Thomas; Lynn M Corcoran; Raffi Gugasyan; Mathew P Dixon; Thomas Brodnicki; Stephen L Nutt; Donald Metcalf; Anne K Voss
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.
Genes & development 2006;20(9):1175-86.
2006: Axel Kallies; Edwin D Hawkins; Gabrielle Belz; Donald Metcalf; Mirja Hommel; Lynn M Corcoran; Philip D Hodgkin; Stephen L Nutt
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.
Nature immunology 2006;7(5):466-74.
2006: Donald Metcalf
Loss of PU.1: one of the many roads to myeloid leukemia.
Cell cycle (Georgetown, Tex.) 2006;5(7):673-4.
2006: Donald Metcalf; Aleksandar Dakic; Sandra Mifsud; Ladina Di Rago; Li Wu; Stephen L Nutt
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1486-91.
2006: Jennifer E Fenner; Robyn Starr; Ann L Cornish; Jian-Guo Zhang; Donald Metcalf; Robert D Schreiber; Kathleen Sheehan; Douglas J Hilton; Warren S Alexander; Paul J Hertzog
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
Nature immunology 2006;7(1):33-9.
2005: Lorraine Robb; Kristy Boyle; Steven Rakar; Lynne Hartley; Janelle Lochland; Andrew W Roberts; Warren S Alexander; Donald Metcalf
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16333-8.
2005: Marc Pellegrini; Sue Bath; Vanessa S Marsden; David C S Huang; Donald Metcalf; Alan W Harris; Andreas Strasser
FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.
Blood 2005;106(5):1581-9.
2005: seth masters; Kirsten R Palmer; W S Stevenson; Donald Metcalf; Elizabeth M Viney; Naomi S Sprigg; Warren S Alexander; Nicos A Nicola; Sandra E Nicholson
Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia.
Molecular and cellular biology 2005;25(13):5639-47.
2005: Aleksandar Dakic; Donald Metcalf; Ladina Di Rago; Sandra Mifsud; Li Wu; Stephen L Nutt
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.
The Journal of experimental medicine 2005;201(9):1487-502.
2005: Donald Metcalf; Marina R Carpinelli; Craig D Hyland; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.
Blood 2005;105(9):3480-7.
2005: Sandra E Nicholson; Donald Metcalf; Naomi S Sprigg; Ruth Columbus; Francesca Walker; Anabel Silva; Dale Cary; Tracy A Willson; Jian-Guo Zhang; Douglas J Hilton; Warren S Alexander; Nicos A Nicola
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2328-33.
2005: Christopher J Greenhalgh; Elizabeth Rico-Bautista; Mattias Lorentzon; Anne L Thaus; Phillip O Morgan; Tracy A Willson; Panagiota Zervoudakis; Donald Metcalf; Ian Street; Nicos A Nicola; Andrew D Nash; Louis J Fabri; Gunnar Norstedt; Claes Ohlsson; Amilcar Flores-Morales; Warren S Alexander; Douglas J Hilton
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
The Journal of clinical investigation 2005;115(2):397-406.
2005: Stephen L Nutt; Donald Metcalf; Angela D'Amico; Matthew Polli; Li Wu
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors.
The Journal of experimental medicine 2005;201(2):221-31.
2005: Donald Metcalf; Sandra Mifsud; Ladina Di Rago
Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF.
Stem cells (Dayton, Ohio) 2005;23(1):55-62.
2004: Danielle L Krebs; Donald Metcalf; Tobias Merson; Anne K Voss; Tim Thomas; Jian-Guo Zhang; Steven Rakar; Moira K O'Bryan; Tracy A Willson; Elizabeth M Viney; Lisa A Mielke; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Development of hydrocephalus in mice lacking SOCS7.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15446-51.
2004: Kate E Lawlor; Ian K Campbell; Donald Metcalf; Kristy O'Donnell; Annemarie van Nieuwenhuijze; Andrew W Roberts; Ian P Wicks
Critical role for granulocyte colony-stimulating factor in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11398-403.
2004: Christine Brender; Ruth Columbus; Donald Metcalf; Emanuela Handman; Robyn Starr; Nick Huntington; David M Tarlinton; Niels Ødum; Sandra E Nicholson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
Molecular and cellular biology 2004;24(13):6094-103.
2004: Marina R Carpinelli; Douglas J Hilton; Donald Metcalf; Jennifer Antonchuk; Craig D Hyland; Sandra Mifsud; Ladina Di Rago; Adrienne A Hilton; Tracy A Willson; Andrew W Roberts; Robert G Ramsay; Nicos A Nicola; Warren S Alexander
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6553-8.
2004: Ben A Croker; Donald Metcalf; Lorraine Robb; Wei Wei; Sandra Mifsud; Ladina DiRago; Leonie A Cluse; Kate D Sutherland; Lynne Hartley; Emily Williams; Jian-Guo Zhang; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Immunity 2004;20(2):153-65.
2004: W Douglas Fairlie; Alessandro D Uboldi; Joanne E McCoubrie; Chunxiao C Wang; Erinna Lee; Shenggen Yao; David P De Souza; Sandra Mifsud; Donald Metcalf; Nicos A Nicola; Raymond S Norton; Manuel Baca
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.
The Journal of biological chemistry 2004;279(3):2125-34.
2003: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Warren S Alexander
The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8436-41.
2003: Ben A Croker; Danielle L Krebs; Jian-Guo Zhang; Samuel Wormald; Tracy A Willson; Edouard G Stanley; Lorraine Robb; Christopher J Greenhalgh; Irmgard Förster; Björn E Clausen; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Andrew W Roberts; Warren S Alexander
SOCS3 negatively regulates IL-6 signaling in vivo.
Nature immunology 2003;4(6):540-5.
2003: David M Tarlinton; Amanda Light; Donald Metcalf; Richard P Harvey; Lorraine Robb
Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4002-10.
2003: Mark A Hall; David J Curtis; Donald Metcalf; Andrew G Elefanty; Koula Sourris; Lorraine Robb; Joachim R Gothert; Stephen M Jane; C Glenn Begley
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):992-7.
2003: Donald Metcalf; Ladina Di Rago; Sandra Mifsud
Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1244-9.
2003: Ann L Cornish; Gayle M Davey; Donald Metcalf; Jared F Purton; Jason E Corbin; Christopher J Greenhalgh; Rima Darwiche; Li Wu; Nicos A Nicola; Dale I Godfrey; William R Heath; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):878-86.
2003: Donald Metcalf
The unsolved enigmas of leukemia inhibitory factor.
Stem cells (Dayton, Ohio) 2003;21(1):5-14.
2002: Joanne L Eyles; Donald Metcalf; Michael J Grusby; Douglas J Hilton; Robyn Starr
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.
The Journal of biological chemistry 2002;277(46):43735-40.
2002: Christopher J Greenhalgh; Donald Metcalf; Anne L Thaus; Jason E Corbin; Rachel Uren; Phillip O Morgan; Louis J Fabri; Jian-Guo Zhang; Helene M Martin; Tracy A Willson; Nils Billestrup; Nicos A Nicola; Manuel Baca; Warren S Alexander; Douglas J Hilton
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
The Journal of biological chemistry 2002;277(43):40181-4.
2002: Vanessa S Marsden; Liam O'Connor; Lorraine A O'Reilly; John Silke; Donald Metcalf; Paul G Ekert; David C S Huang; Francesco Cecconi; Keisuke Kuida; Kevin J Tomaselli; Sophie Roy; Don W Nicholson; David L Vaux; Philippe Bouillet; Jerry M Adams; Andreas Strasser
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Nature 2002;419(6907):634-7.
2002: Jacqueline M Tarrant; Joanna Groom; Donald Metcalf; Ruili Li; Bette Borobokas; Mark D Wright; David M Tarlinton; Lorraine Robb
The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
Molecular and cellular biology 2002;22(14):5006-18.
2002: Danielle L Krebs; Rachel Uren; Donald Metcalf; Steven Rakar; Jian-Guo Zhang; Robyn Starr; David P De Souza; Kathy Hanzinikolas; Jo Eyles; Lisa M Connolly; Richard J Simpson; Nicos A Nicola; Sandra E Nicholson; Manuel Baca; Douglas J Hilton; Warren S Alexander
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Molecular and cellular biology 2002;22(13):4567-78.
2002: Christopher J Greenhalgh; Patrick Bertolino; Sylvia Asa; Donald Metcalf; Jason E Corbin; Timothy E Adams; Helen W Davey; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b).
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1394-406.
2002: Thomas Pohl; Raffi Gugasyan; Raelene J Grumont; Andreas Strasser; Donald Metcalf; David M Tarlinton; William Sha; David Baltimore; Steve Gerondakis
The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4514-9.
2002: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):943-8.
2002: Donald Metcalf; Ladina Di Rago; Sandra Mifsud
Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation.
Stem cells (Dayton, Ohio) 2002;20(6):552-60.
2002: Donald Metcalf; Sandra Mifsud; Ladina Di Rago
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio) 2002;20(5):460-9.
2001: Jian-Guo Zhang; Donald Metcalf; Steven Rakar; M Asimakis; Christopher J Greenhalgh; Tracy A Willson; Robyn Starr; Sandra E Nicholson; W Carter; Warren S Alexander; Douglas J Hilton; Nicos A Nicola
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13261-5.
2001: Donald Metcalf; Warren S Alexander; P J Ryan; Sandra Mifsud; Ladina Di Rago
Production of colony-stimulating factors and IL-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4661-7.
2001: Denise V R Bullen; Rima Darwiche; Donald Metcalf; Emanuela Handman; Warren S Alexander
Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease.
Immunology 2001;104(1):92-8.
2001: Benjamin T Kile; Donald Metcalf; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Functional analysis of Asb-1 using genetic modification in mice.
Molecular and cellular biology 2001;21(18):6189-97.
2001: P J Ryan; Tracy A Willson; Warren S Alexander; Ladina Di Rago; Sandra Mifsud; Donald Metcalf
The multi-organ origin of interleukin-5 in the mouse.
Leukemia 2001;15(8):1248-55.
2001: Andrew W Roberts; Lorraine Robb; Steven Rakar; Lynne Hartley; Leonie A Cluse; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Warren S Alexander
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9324-9.
2001: Donald Metcalf; Yacine LAABI
Lineage commitment and maturation induction in normal and leukemic preprogenitor cells.
Annals of the New York Academy of Sciences 2001;938():278-91; discussion 291-2.
2001: K A Kelly; Karen M Lucas; Hubertus Hochrein; Donald Metcalf; Li Wu; Ken Shortman
Development of dendritic cells in culture from human and murine thymic precursor cells.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(1):43-54.
2000: Yacine LAABI; Donald Metcalf; Sandra Mifsud; Ladina Di Rago
Differentiation commitment and regulator-specific granulocyte-macrophage maturation in a novel pro-B murine leukemic cell line.
Leukemia 2000;14(10):1785-95.
2000: Donald Metcalf; Ladina Di Rago; Sandra Mifsud; Lynne Hartley; Warren S Alexander
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9174-9.
2000: Donald Metcalf; Christopher J Greenhalgh; Elizabeth M Viney; Tracy A Willson; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Gigantism in mice lacking suppressor of cytokine signalling-2.
Nature 2000;405(6790):1069-73.
2000: Sandra E Nicholson; David P De Souza; Louis J Fabri; Jason Corbin; Tracy A Willson; Jian-Guo Zhang; A Silva; M Asimakis; A Farley; Andrew D Nash; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6493-8.
2000: M Hasegawa; T M Baldwin; Donald Metcalf; Simon J Foote
Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11.
Blood 2000;95(5):1872-4.
2000: T Gainsford; Harshal H Nandurkar; Donald Metcalf; Lorraine Robb; C Glenn Begley; Warren S Alexander
The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.
Blood 2000;95(2):528-34.
2000: David J Curtis; Donald Metcalf; B Alexander; C Glenn Begley
Leukemic cells from murine myeloid leukemia display an intrinsic ability for autonomous proliferation.
Experimental hematology 2000;28(1):36-45.
1999: Sarah Ogilvy; Donald Metcalf; Cristin G Print; Mary L Bath; Alan W Harris; Jerry M Adams
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14943-8.
1999: Donald Metcalf
The SOCS-1 story.
Experimental hematology 1999;27(12):1715-23.
1999: Philippe Bouillet; Donald Metcalf; David C S Huang; David M Tarlinton; T W Kay; F Köntgen; Jerry M Adams; Andreas Strasser
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Science (New York, N.Y.) 1999;286(5445):1735-8.
1999: M Grossmann; Donald Metcalf; J Merryfull; Amer A Beg; David Baltimore; Steve Gerondakis
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11848-53.
1999: Donald Metcalf
Cellular hematopoiesis in the twentieth century.
Seminars in hematology 1999;36(4 Suppl 7):5-12.
1999: Warren S Alexander; Robyn Starr; Donald Metcalf; Sandra E Nicholson; A Farley; Andrew G Elefanty; M Brysha; Benjamin T Kile; R Richardson; Manuel Baca; Jian-Guo Zhang; Tracy A Willson; Elizabeth M Viney; Naomi S Sprigg; Steven Rakar; Jason Corbin; Sandra Mifsud; Ladina DiRago; Dale Cary; Nicos A Nicola; Douglas J Hilton
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Journal of leukocyte biology 1999;66(4):588-92.
1999: Sarah Ogilvy; Donald Metcalf; L Gibson; Mary L Bath; Alan W Harris; Jerry M Adams
Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment.
Blood 1999;94(6):1855-63.
1999: Warren S Alexander; Robyn Starr; Jennifer E Fenner; Clare L Scott; Emanuela Handman; Naomi S Sprigg; Jason E Corbin; Ann L Cornish; Rima Darwiche; Catherine M Owczarek; Thomas W H Kay; Nicos A Nicola; Paul J Hertzog; Donald Metcalf; Douglas J Hilton
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Cell 1999;98(5):597-608.
1999: Warren S Alexander; Steven Rakar; Lorraine Robb; A Farley; Tracy A Willson; Jian-Guo Zhang; Lynne Hartley; Y Kikuchi; T Kojima; H Nomura; M Hasegawa; M Maeda; Louis J Fabri; K Jachno; Andrew D Nash; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
Current biology : CB 1999;9(11):605-8.
1999: Donald Metcalf; Warren S Alexander; Andrew G Elefanty; Nicos A Nicola; Douglas J Hilton; Robyn Starr; Sandra Mifsud; Ladina Di Rago
Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1.
Leukemia 1999;13(6):926-34.
1999: Donald Metcalf
Stem cells, pre-progenitor cells and lineage-committed cells: are our dogmas correct?
Annals of the New York Academy of Sciences 1999;872():289-303; discussion 303-4.
1999: Jian-Guo Zhang; A Farley; Sandra E Nicholson; Tracy A Willson; L M Zugaro; Richard J Simpson; Robert L Moritz; Dale Cary; R Richardson; George Hausmann; B J Kile; S B Kent; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2071-6.
1999: Donald Metcalf; Nicos A Nicola; Sandra Mifsud; Ladina Di Rago
Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections.
Blood 1999;93(5):1579-85.
1999: Sandra E Nicholson; Tracy A Willson; A Farley; Robyn Starr; Jian-Guo Zhang; Manuel Baca; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The EMBO journal 1999;18(2):375-85.
1999: N Cambier; Y Zhang; G Vairo; K Kosmopoulos; Donald Metcalf; Nicos A Nicola; Andrew G Elefanty
Expression of BCR - ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation.
Oncogene 1999;18(2):343-52.
1999: Nicos A Nicola; Sandra E Nicholson; Donald Metcalf; Jian-Guo Zhang; Manuel Baca; A Farley; Tracy A Willson; Robyn Starr; W Alexander; Douglas J Hilton
Negative regulation of cytokine signaling by the SOCS proteins.
Cold Spring Harbor symposia on quantitative biology 1999;64():397-404.
1999: Donald Metcalf
On relevance.
Stem cells (Dayton, Ohio) 1999;17(1):1-8.
1998: Y Zhang; Tracy A Willson; Donald Metcalf; Dale Cary; Douglas J Hilton; R Clark; Nicos A Nicola
The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.
The Journal of biological chemistry 1998;273(51):34370-83.
1998: Robyn Starr; Donald Metcalf; Andrew G Elefanty; M Brysha; Tracy A Willson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14395-9.
1998: Cristin G Print; Kate L Loveland; L Gibson; Terri Meehan; A Stylianou; Nigel G Wreford; David M de Kretser; Donald Metcalf; F Köntgen; Jerry M Adams; Suzanne Cory
Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12424-31.
1998: Donald Metcalf
Cell-cell signalling in the regulation of blood cell formation and function.
Immunology and cell biology 1998;76(5):441-7.
1998: Andrew G Elefanty; C Glenn Begley; Donald Metcalf; Louise Barnett; F Köntgen; Lorraine Robb
Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11897-902.
1998: Donald Metcalf
Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation.
Blood 1998;92(2):345-7; discussion 352.
1998: Donald Metcalf
Lineage commitment in the progeny of murine hematopoietic preprogenitor cells: influence of thrombopoietin and interleukin 5.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6408-12.
1998: T Gainsford; A W Roberts; S Kimura; Donald Metcalf; Glenn Dranoff; R C Mulligan; C Glenn Begley; Lorraine Robb; Warren S Alexander
Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production.
Blood 1998;91(8):2745-52.
1998: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Lorraine Robb; Nicos A Nicola; W Alexander
The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF.
Leukemia 1998;12(3):353-62.
1998: S Kimura; A W Roberts; Donald Metcalf; Warren S Alexander
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1195-200.
1998: N Cambier; R Chopra; Andreas Strasser; Donald Metcalf; Andrew G Elefanty
BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner.
Oncogene 1998;16(3):335-48.
1998: Douglas J Hilton; Rachael Richardson; Warren S Alexander; Elizabeth M Viney; Tracy A Willson; Naomi S Sprigg; Robyn Starr; Sandra E Nicholson; Donald Metcalf; Nicos A Nicola
Twenty proteins containing a C-terminal SOCS box form five structural classes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):114-9.
1998: Donald Metcalf
The molecular control of hematopoiesis: progress and problems with gene manipulation.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():1-9.
1998: Donald Metcalf
Regulatory mechanisms controlling hematopoiesis: principles and problems.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():3-11.
1998: Donald Metcalf
The molecular control of hematopoiesis: progress and problems with gene manipulation.
Stem cells (Dayton, Ohio) 1998;16(5):314-21.
1997: Donald Metcalf; N A Nicola; L Robb
Differentiation commitment in normal hemopoiesis and leukemic transformation.
Journal of cellular physiology 1997;173(2):131-4.
1997: Donald Metcalf
Murine hematopoietic stem cells committed to macrophage/dendritic cell formation: stimulation by Flk2-ligand with enhancement by regulators using the gp130 receptor chain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11552-6.
1997: Donald Metcalf
The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias.
Leukemia 1997;11(10):1599-604.
1997: Catherine M Owczarek; Y Zhang; M J Layton; Donald Metcalf; B Roberts; Nicos A Nicola
The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain.
The Journal of biological chemistry 1997;272(38):23976-85.
1997: Robyn Starr; Tracy A Willson; Elizabeth M Viney; L J Murray; J R Rayner; Brendan J Jenkins; Thomas J Gonda; Warren S Alexander; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
A family of cytokine-inducible inhibitors of signalling.
Nature 1997;387(6636):917-21.
1997: John Rasko; Donald Metcalf; B Alexander; Andreas Strasser; C Glenn Begley
Establishment of multipotential and antigen presenting cell lines derived from myeloid leukemias in GM-CSF transgenic mice.
Leukemia 1997;11(5):732-42.
1997: Andrew W Roberts; Simon J Foote; Warren S Alexander; C Scott; Lorraine Robb; Donald Metcalf
Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor.
Blood 1997;89(8):2736-44.
1997: Jian-Guo Zhang; Douglas J Hilton; Tracy A Willson; C McFarlane; B A Roberts; Robert L Moritz; Richard J Simpson; Warren S Alexander; Donald Metcalf; Nicos A Nicola
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.
The Journal of biological chemistry 1997;272(14):9474-80.
1997: Donald Metcalf
Suppression or overexpression of genes encoding myeloid growth factors or their receptors.
Hematology and cell therapy 1997;39(2):98-101.
1997: Donald Metcalf
The molecular control of granulocytes and macrophages.
Ciba Foundation symposium 1997;204():40-50; discussion 50-6.
1997: Nicos A Nicola; A Smith; Lorraine Robb; Donald Metcalf; C Glenn Begley
The structural basis of the biological actions of the GM-CSF receptor.
Ciba Foundation symposium 1997;204():19-27; discussion 27-32.
1997: David Vremec; GJ Lieschke; Ashley R Dunn; Lorraine Robb; Donald Metcalf; Ken Shortman
The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs.
European journal of immunology 1997;27(1):40-4.
1997: W J McKinstry; C L Li; John Rasko; Nicos A Nicola; G R Johnson; Donald Metcalf
Cytokine receptor expression on hematopoietic stem and progenitor cells.
Blood 1997;89(1):65-71.
1996: G Grigoriadis; Y Zhan; Raelene J Grumont; Donald Metcalf; E Handman; Christina Cheers; Steve Gerondakis
The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.
The EMBO journal 1996;15(24):7099-107.
1996: T Gainsford; Tracy A Willson; Donald Metcalf; E Handman; C McFarlane; Ashley Ng; Nicos A Nicola; Warren S Alexander; Douglas J Hilton
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14564-8.
1996: Donald Metcalf
Forty years at the pitface in the Walter and Eliza Hall Institute of Medical Research.
The Medical journal of Australia 1996;165(11-12):652-5.
1996: Donald Metcalf; Lorraine Robb; Ashley R Dunn; Sandra Mifsud; Ladina Di Rago
Role of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in the development of an acute neutrophil inflammatory response in mice.
Blood 1996;88(10):3755-64.
1996: C Glenn Begley; John Rasko; D Curtis; K Takagi; Donald Metcalf; D Hilton; B Roberts; Nicos A Nicola; M T Rossner
Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal.
Experimental hematology 1996;24(10):1247-57.
1996: Steve Gerondakis; Andreas Strasser; Donald Metcalf; G Grigoriadis; J Y Scheerlinck; Raelene J Grumont
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3405-9.
1996: Nicos A Nicola; Lorraine Robb; Donald Metcalf; Dale Cary; C C Drinkwater; C Glenn Begley
Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells.
Blood 1996;87(7):2665-74.
1996: Donald Metcalf; Ken Shortman; David Vremec; Sandra Mifsud; Ladina Di Rago
Effects of excess GM-CSF levels on hematopoiesis and leukemia development in GM-CSF/max 41 double transgenic mice.
Leukemia 1996;10(4):713-9.
1996: Warren S Alexander; Andrew W Roberts; Nicos A Nicola; R Li; Donald Metcalf
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
Blood 1996;87(6):2162-70.
1996: Donald Metcalf; Andrew W Roberts; Tracy A Willson
The regulation of hematopoiesis in max 41 transgenic mice with sustained excess granulopoiesis.
Leukemia 1996;10(2):311-20.
1996: Douglas J Hilton; Jian-Guo Zhang; Donald Metcalf; Warren S Alexander; Nicos A Nicola; Tracy A Willson
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):497-501.
1996: Warren S Alexander; Andrew W Roberts; A B Maurer; Nicos A Nicola; Ashley R Dunn; Donald Metcalf
Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():124-32.
1995: John Rasko; Donald Metcalf; M T Rossner; C Glenn Begley; Nicos A Nicola
The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation.
Leukemia 1995;9(12):2058-66.
1995: P M Waring; J Presneill; Darryl W Maher; Judith E Layton; Jonathan Cebon; L J Waring; Donald Metcalf
Differential alterations in plasma colony-stimulating factor concentrations in meningococcaemia.
Clinical and experimental immunology 1995;102(3):501-6.
1995: Warren S Alexander; Donald Metcalf; Ashley R Dunn
Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.
The EMBO journal 1995;14(22):5569-78.
1995: Lorraine Robb; C C Drinkwater; Donald Metcalf; R Li; F Köntgen; Nicos A Nicola; C Glenn Begley
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9565-9.
1995: Donald Metcalf
In memoriam Professor Laszlo G. Lajtha 1920-1995.
Stem cells (Dayton, Ohio) 1995;13(5):571-3.
1995: Andrew W Roberts; E DeLuca; C Glenn Begley; Russell L Basser; A P Grigg; Donald Metcalf
Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy.
Stem cells (Dayton, Ohio) 1995;13(5):512-6.
1995: Donald Metcalf; Tracy A Willson; Douglas J Hilton; Ladina Di Rago; Sandra Mifsud
Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays.
Leukemia 1995;9(9):1556-64.
1995: F Köntgen; Raelene J Grumont; Andreas Strasser; Donald Metcalf; R Li; David M Tarlinton; Steve Gerondakis
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
Genes & development 1995;9(16):1965-77.
1995: A W Roberts; Donald Metcalf
Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines.
Blood 1995;86(4):1600-5.
1995: Catherine M Owczarek; M J Layton; Donald Metcalf; R Clark; N M Gough; Nicos A Nicola
Inter-species chimeras of leukemia inhibitory factor define a human receptor binding site.
Annals of the New York Academy of Sciences 1995;762():165-78.
1995: Lorraine Robb; I Lyons; R Li; Lynne Hartley; F Köntgen; Richard P Harvey; Donald Metcalf; C Glenn Begley
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7075-9.
1995: Donald Metcalf
The granulocyte-macrophage regulators: reappraisal by gene inactivation.
Experimental hematology 1995;23(7):569-72.
1995: Donald Metcalf; G J Lindeman; Nicos A Nicola
Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes.
Blood 1995;85(9):2364-70.
1995: John Rasko; Donald Metcalf; N M Gough; C Glenn Begley
The cytokine receptor repertoire specifies autocrine growth factor production in factor-dependent cells.
Experimental hematology 1995;23(5):453-60.
1995: P M Waring; L J Waring; T Billington; Donald Metcalf
Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1337-41.
1995: G A McArthur; Donald Metcalf; Steven Rakar; G R Johnson
Overexpression of C-FMS in the myeloid cell line FDC-P1 induces transformation that dissociates M-CSF-induced proliferation and differentiation.
Leukemia 1995;9(1):68-76.
1994: M J Layton; Catherine M Owczarek; Donald Metcalf; R L Clark; D K Smith; Herbert Treutlein; Nicos A Nicola
Conversion of the biological specificity of murine to human leukemia inhibitory factor by replacing 6 amino acid residues.
The Journal of biological chemistry 1994;269(47):29891-6.
1994: P M Waring; L J Waring; Donald Metcalf
Circulating leukemia inhibitory factor levels correlate with disease severity in meningococcemia.
The Journal of infectious diseases 1994;170(5):1224-8.
1994: Donald Metcalf
The 1993 Burnet Lecture. The colony stimulating factors--discovery to clinical use.
Australasian biotechnology 1994;4(6):337-40.
1994: Douglas J Hilton; A A Hilton; A Raicevic; Steven Rakar; M Harrison-Smith; N M Gough; C Glenn Begley; Donald Metcalf; Nicos A Nicola; Tracy A Willson
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
The EMBO journal 1994;13(20):4765-75.
1994: W McKinstry; Donald Metcalf; C L Li
Distribution of IL-6 receptors on murine hemopoietic and lymphoid cells and the anomalous action of IL-6 in stimulating granulocytic proliferation.
Leukemia 1994;8(10):1726-33.
1994: GJ Lieschke; Dianne Grail; George Hodgson; Donald Metcalf; E Stanley; Christina Cheers; K J Fowler; Sunanda Basu; Yifan Zhan; Ashley R Dunn
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.
Blood 1994;84(6):1737-46.
1994: M J Layton; Catherine M Owczarek; Donald Metcalf; P A Lock; T A Wilson; N M Gough; Douglas J Hilton; Nicos A Nicola
Complex binding of leukemia inhibitory factor to its membrane-expressed and soluble receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):295-8.
1994: M J Layton; P Lock; Donald Metcalf; Nicos A Nicola
Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction.
The Journal of biological chemistry 1994;269(25):17048-55.
1994: E Stanley; GJ Lieschke; Dianne Grail; Donald Metcalf; George Hodgson; J A Gall; Darryl W Maher; Jonathan Cebon; V Sinickas; Ashley R Dunn
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5592-6.
1994: M A Brown; Donald Metcalf; N M Gough
Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation.
Cytokine 1994;6(3):300-9.
1994: M T Rossner; G A McArthur; J D Allen; Donald Metcalf
Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(5):549-55.
1994: F Sotzik; Y Rosenberg; A W Boyd; Margo Honeyman; Donald Metcalf; Roland Scollay; Li Wu; Ken Shortman
Assessment of CD4 expression by early T precursor cells and by dendritic cells in the human thymus.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3370-7.
1994: P Lock; Donald Metcalf; Nicos A Nicola
Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):252-6.
1994: Donald Metcalf
Hemopoietic regulators and leukemia development: a personal retrospective.
Advances in cancer research 1994;63():41-91.
1994: Donald Metcalf
Implications of the polyfunctionality of hemopoietic regulators.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():259-75.
1994: Donald Metcalf; Tracy A Willson; M Rossner; P Lock
Receptor insertion into factor-dependent murine cell lines to develop specific bioassays for murine G-CSF and M-CSF and human GM-CSF.
Growth factors (Chur, Switzerland) 1994;11(2):145-52.
1993: Donald Metcalf
Hematopoietic regulators: redundancy or subtlety?
Blood 1993;82(12):3515-23.
1993: N J Elwood; W D Cook; Donald Metcalf; C Glenn Begley
SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line.
Oncogene 1993;8(11):3093-101.
1993: Nicos A Nicola; K Wycherley; A W Boyd; J E Layton; Dale Cary; Donald Metcalf
Neutralizing and nonneutralizing monoclonal antibodies to the human granulocyte-macrophage colony-stimulating factor receptor alpha-chain.
Blood 1993;82(6):1724-31.
1993: Catherine M Owczarek; M J Layton; Donald Metcalf; P Lock; Tracy A Willson; N M Gough; Nicos A Nicola
Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant.
The EMBO journal 1993;12(9):3487-95.
1993: Donald Metcalf
The molecular control of proliferation and differentiation in hemopoietic cells.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(9):860-70.
1993: T Tanigawa; N Elwood; Donald Metcalf; Dale Cary; E DeLuca; Nicos A Nicola; C Glenn Begley
The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7864-8.
1993: P M Waring; G J Carroll; D A Kandiah; G Buirski; Donald Metcalf
Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides.
Arthritis and rheumatism 1993;36(7):911-5.
1993: Donald Metcalf
The cellular basis for enhancement interactions between stem cell factor and the colony stimulating factors.
Stem cells (Dayton, Ohio) 1993;11 Suppl 2():1-11.
1993: Donald Metcalf; John Rasko
Leukemic transformation of immortalized FDC-P1 cells engrafted in GM-CSF transgenic mice.
Leukemia 1993;7(6):878-86.
1993: P Waring; D Wall; R Dauer; D Parkin; Donald Metcalf
The effects of leukaemia inhibitory factor on platelet function.
British journal of haematology 1993;83(1):80-7.
1992: M J Elliott; B E Faulkner-Jones; H Stanton; J A Hamilton; Donald Metcalf
Plasminogen activator in granulocyte-macrophage-CSF transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(11):3678-81.
1992: Donald Metcalf
The hemopoietic regulators--an embarrassment of riches.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(12):799-805.
1992: P Waring; K Wycherley; Dale Cary; Nicos A Nicola; Donald Metcalf
Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids.
The Journal of clinical investigation 1992;90(5):2031-7.
1992: M J Layton; B A Cross; Donald Metcalf; L D Ward; Richard J Simpson; Nicos A Nicola
A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8616-20.
1992: Donald Metcalf; Nicos A Nicola
The clonal proliferation of normal mouse hematopoietic cells: enhancement and suppression by colony-stimulating factor combinations.
Blood 1992;79(11):2861-6.
1992: Donald Metcalf; Nicos A Nicola; N M Gough; M Elliott; G McArthur; M Li
Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2819-23.
1992: Donald Metcalf; M J Elliott; Nicos A Nicola
The excess numbers of peritoneal macrophages in granulocyte-macrophage colony-stimulating factor transgenic mice are generated by local proliferation.
The Journal of experimental medicine 1992;175(4):877-84.
1992: Donald Metcalf
Mechanisms responsible for size differences between hemopoietic colonies: an analysis using a CSF-dependent hemopoietic cell line.
International journal of cell cloning 1992;10(2):116-25.
1992: Tracy A Willson; Donald Metcalf; N M Gough
Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein.
European journal of biochemistry / FEBS 1992;204(1):21-30.
1992: J L Villeval; Donald Metcalf; G R Johnson
Fatal polycythemia induced in mice by dysregulated erythropoietin production by hematopoietic cells.
Leukemia 1992;6(2):107-15.
1992: Donald Metcalf
Role of hemopoietic growth factors in the development and suppression of myeloid leukemia.
Leukemia 1992;6 Suppl 3():187S-188S.
1992: Donald Metcalf
Leukemia inhibitory factor--a puzzling polyfunctional regulator.
Growth factors (Chur, Switzerland) 1992;7(3):169-73.
1992: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and binding properties of receptors for leukaemia inhibitory factor.
Ciba Foundation symposium 1992;167():227-39; discussion 239-44.
1992: Donald Metcalf; P Waring; Nicos A Nicola
Actions of leukaemia inhibitory factor on megakaryocyte and platelet formation.
Ciba Foundation symposium 1992;167():174-82; discussion 182-7.
1992: Donald Metcalf
Polyfunctional cytokines: IL-6 and LIF. Introduction.
Ciba Foundation symposium 1992;167():1-4.
1991: Donald Metcalf
Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11310-4.
1991: M J Elliott; A Strasser; Donald Metcalf
Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2957-63.
1991: Donald Metcalf
Control of granulocytes and macrophages: molecular, cellular, and clinical aspects.
Science (New York, N.Y.) 1991;254(5031):529-33.
1991: Nicos A Nicola; Donald Metcalf
Subunit promiscuity among hemopoietic growth factor receptors.
Cell 1991;67(1):1-4.
1991: Douglas J Hilton; Nicos A Nicola; P M Waring; Donald Metcalf
Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice.
Journal of cellular physiology 1991;148(3):430-9.
1991: Donald Metcalf
The Florey Lecture, 1991. The colony-stimulating factors: discovery to clinical use.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1991;333(1266):147-73.
1991: Donald Metcalf; Nicos A Nicola
Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6239-43.
1991: Donald Metcalf
Transgenic mice as models of hemopoiesis.
Cancer 1991;67(10 Suppl):2695-9.
1991: Donald Metcalf; D Hilton; Nicos A Nicola
Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.
Blood 1991;77(10):2150-3.
1991: Donald Metcalf; P C Nowell; J D Rowley; L Sachs
Chromosomal and growth factor abnormalities in leukemia. AACR special conference in cancer research.
Cancer research 1991;51(9):2494-7.
1991: Suzanne Cory; T Maekawa; J McNeall; Donald Metcalf
Murine erythroid cell lines derived with c-myc retroviruses respond to leukemia-inhibitory factor, erythropoietin, and interleukin 3.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(3):165-72.
1991: Donald Metcalf
The leukemia inhibitory factor (LIF).
International journal of cell cloning 1991;9(2):95-108.
1991: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells.
Journal of cellular physiology 1991;146(2):207-15.
1991: C Glenn Begley; J Visvader; Anthony R Green; Peter D Aplan; Donald Metcalf; Ilan R Kirsch; N M Gough
Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):869-73.
1990: J L Villeval; A Gearing; Donald Metcalf
Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. II. Nonerythroid populations.
Experimental parasitology 1990;71(4):375-85.
1990: J L Villeval; A Lew; Donald Metcalf
Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. I. Erythropoietic populations.
Experimental parasitology 1990;71(4):364-74.
1990: Donald Metcalf; Nicos A Nicola; D P Gearing
Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice.
Blood 1990;76(1):50-6.
1990: Donald Metcalf; Nicos A Nicola; D P Gearing; N M Gough
Low-affinity placenta-derived receptors for human granulocyte-macrophage colony-stimulating factor can deliver a proliferative signal to murine hemopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4670-4.
1990: Donald Metcalf
The colony stimulating factors. Discovery, development, and clinical applications.
Cancer 1990;65(10):2185-95.
1990: Donald Metcalf
The consequences of excess levels of haemopoietic growth factors.
British journal of haematology 1990;75(1):1-3.
1990: Donald Metcalf
The induction and inhibition of differentiation in normal and leukaemic cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):99-109.
1990: T Maekawa; Donald Metcalf; D P Gearing
Enhanced suppression of human myeloid leukemic cell lines by combinations of IL-6, LIF, GM-CSF and G-CSF.
International journal of cancer. Journal international du cancer 1990;45(2):353-8.
1990: U Dührsen; Donald Metcalf
Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines.
Blood 1990;75(1):190-7.
1990: Anne Kelso; Donald Metcalf
T lymphocyte-derived colony-stimulating factors.
Advances in immunology 1990;48():69-105.
1990: J L Villeval; U Dührsen; G Morstyn; Donald Metcalf
Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advanced malignancies.
British journal of haematology 1990;74(1):36-44.
1990: Donald Metcalf
Disease states induced by hemopoietic growth factor excess: their implications in medicine.
International journal of cell cloning 1990;8 Suppl 1():374-87; discussion 387-90.
1989: U Dührsen; Donald Metcalf
Factors influencing the time and site of leukemic transformation of factor-dependent cells after injection into irradiated recipient mice.
International journal of cancer. Journal international du cancer 1989;44(6):1074-81.
1989: Donald Metcalf; D P Gearing
A myelosclerotic syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor (LIF).
Leukemia 1989;3(12):847-52.
1989: U Dührsen; Donald Metcalf; G J Spangrude; Nicos A Nicola
PGM-1: a transplantable murine leukemia of granulocyte-macrophage progenitor cells.
Leukemia 1989;3(11):796-803.
1989: J M Chang; Donald Metcalf; Thomas J Gonda; G R Johnson
Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.
The Journal of clinical investigation 1989;84(5):1488-96.
1989: Donald Metcalf; D P Gearing
Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5948-52.
1989: A J Gearing; Donald Metcalf; J G Moore; Nicos A Nicola
Elevated levels of GM-CSF and IL-1 in the serum, peritoneal and pleural cavities of GM-CSF transgenic mice.
Immunology 1989;67(2):216-20.
1989: Donald Metcalf
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.
Nature 1989;339(6219):27-30.
1989: J M Chang; Donald Metcalf; Richard Lang; Thomas J Gonda; G R Johnson
Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression.
Blood 1989;73(6):1487-97.
1989: Donald Metcalf
The roles of stem cell self-renewal and autocrine growth factor production in the biology of myeloid leukemia.
Cancer research 1989;49(9):2305-11.
1989: Donald Metcalf
Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells.
Leukemia 1989;3(5):349-55.
1989: Donald Metcalf
Haemopoietic growth factors 2: clinical applications.
Lancet 1989;1(8643):885-7.
1989: Donald Metcalf
Haemopoietic growth factors 1.
Lancet 1989;1(8642):825-7.
1989: T Maekawa; Donald Metcalf
Clonal suppression of HL60 and U937 cells by recombinant human leukemia inhibitory factor in combination with GM-CSF or G-CSF.
Leukemia 1989;3(4):270-6.
1989: Donald Metcalf
Hemopoietic growth factor gene transfer.
Transplantation proceedings 1989;21(1 Pt 1):65-6.
1989: G R Johnson; Thomas J Gonda; Donald Metcalf; I K Hariharan; Suzanne Cory
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.
The EMBO journal 1989;8(2):441-8.
1989: I K Hariharan; G R Johnson; Thomas J Gonda; Donald Metcalf; Jerry M Adams; Suzanne Cory
Analysis of the leukemogenic properties of the bcr-v-abl and GM-CSF genes using a new retroviral vector.
Current topics in microbiology and immunology 1989;149():99-107.
1989: N M Gough; R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; J Stahl; D P Gearing; Nicos A Nicola; Donald Metcalf
LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells.
Reproduction, fertility, and development 1989;1(4):281-8.
1988: R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; C L Stewart; D P Gearing; E F Wagner; Donald Metcalf; Nicos A Nicola; N M Gough
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells.
Nature 1988;336(6200):684-7.
1988: U Dührsen; J L Villeval; J Boyd; G Kannourakis; G Morstyn; Donald Metcalf
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients.
Blood 1988;72(6):2074-81.
1988: Donald Metcalf; J G Moore
Divergent disease patterns in granulocyte-macrophage colony-stimulating factor transgenic mice associated with different transgene insertion sites.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7767-71.
1988: Donald Metcalf
Mechanisms contributing to the sex difference in levels of granulocyte-macrophage colony-stimulating factor in the urine of GM-CSF transgenic mice.
Experimental hematology 1988;16(9):794-800.
1988: L M Corcoran; Donald Metcalf; S J Edwards; Emanuela Handman
GM-CSF produced by recombinant vaccinia virus or in GM-CSF transgenic mice has no effect in vivo on murine cutaneous leishmaniasis.
The Journal of parasitology 1988;74(5):763-7.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Purification of a murine leukemia inhibitory factor from Krebs ascites cells.
Analytical biochemistry 1988;173(2):359-67.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5971-5.
1988: Douglas J Hilton; Nicos A Nicola; N M Gough; Donald Metcalf
Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines.
The Journal of biological chemistry 1988;263(19):9238-43.
1988: U Dührsen; Donald Metcalf
A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient mice.
Leukemia 1988;2(6):329-33.
1988: Donald Metcalf
Haemopoietic growth factors.
The Medical journal of Australia 1988;148(10):516-9.
1988: Donald Metcalf; Nicos A Nicola
Tissue localization and fate in mice of injected multipotential colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3160-4.
1988: D J Williamson; C Glenn Begley; M A Vadas; Donald Metcalf
The detection and initial characterization of colony-stimulating factors in synovial fluid.
Clinical and experimental immunology 1988;72(1):67-73.
1988: N M Gough; D P Gearing; J A King; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2623-7.
1988: Donald Metcalf
Colony stimulating factors and hemopoiesis.
Annals of the Academy of Medicine, Singapore 1988;17(2):166-70.
1988: Donald Metcalf; D J Hilton; Nicos A Nicola
Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.
Leukemia 1988;2(4):216-21.
1988: C Glenn Begley; Nicos A Nicola; Donald Metcalf
Proliferation of normal human promyelocytes and myelocytes after a single pulse stimulation by purified GM-CSF or G-CSF.
Blood 1988;71(3):640-5.
1988: N M Gough; Douglas J Hilton; D P Gearing; Tracy A Willson; J A King; Nicos A Nicola; Donald Metcalf
Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells.
Blood cells 1988;14(2-3):431-42.
1988: Nicos A Nicola; Donald Metcalf
Binding, internalization, and degradation of 125I-multipotential colony-stimulating factor (interleukin-3) by FDCP-1 cells.
Growth factors (Chur, Switzerland) 1988;1(1):29-39.
1988: Nicos A Nicola; L Peterson; Douglas J Hilton; Donald Metcalf
Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines.
Growth factors (Chur, Switzerland) 1988;1(1):41-9.
1988: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Binding characteristics and proliferative action of purified granulocyte colony-stimulating factor (G-CSF) on normal and leukemic human promyelocytes.
Experimental hematology 1988;16(1):71-9.
1987: D P Gearing; N M Gough; J A King; Douglas J Hilton; Nicos A Nicola; Richard J Simpson; Edouard Nice; A Kelso; Donald Metcalf
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
The EMBO journal 1987;6(13):3995-4002.
1987: Donald Metcalf; Thomas M Roberts; V Cherington; Ashley R Dunn
The in vitro behavior of hemopoietic cells transformed by polyoma middle T antigen parallels that of primary human myeloid leukemic cells.
The EMBO journal 1987;6(12):3703-9.
1987: Richard Lang; Donald Metcalf; R A Cuthbertson; I Lyons; E Stanley; A Kelso; G Kannourakis; D J Williamson; G K Klintworth; Thomas J Gonda
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage.
Cell 1987;51(4):675-86.
1987: Donald Metcalf
Comments on editorial by G. Brown and co-workers: Stochastic or ordered lineage commitment during hemopoiesis?
Leukemia 1987;1(5):457.
1987: Donald Metcalf
Hemopoietic growth factors and oncogenes in myeloid leukemia development.
Haematology and blood transfusion 1987;31():16-25.
1987: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors.
Leukemia 1987;1(1):1-8.
1985: Richard Lang; Donald Metcalf; N M Gough; Ashley R Dunn; Thomas J Gonda
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity.
Cell 1985;43(2 Pt 1):531-42.
1985: Nicos A Nicola; Donald Metcalf
The colony-stimulating factors and myeloid leukaemia.
Cancer surveys 1985;4(4):789-815.