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William Metcalf

Research Profile

Living Beings

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Chemicals & Drugs

Physiology

Gene Expression Regulation, Archaeal

Procedures

Phenomena

Oxidation-Reduction

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Publications

TOP 3
William W Metcalf; David A Stahl; Robert M Cicchillo; Benjamin T Circello; Heather A Cooke; Bradley S Evans; Jiangtao Gao; Benjamin M Griffin; Sarath Chandra Janga; Willm Martens-Habbena; Wilfred Adrianus van der Donk
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.
Seung Young Kim; Tomohisa Kuzuyama; William W Metcalf; Bradley S Evans; Kou-San Ju; Wilfred Adrianus van der Donk
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.
John E Hung; Tyler Johannes; William W Metcalf; Harry D Christman; Emily J Fogle; Huimin Zhao; Wilfred Adrianus van der Donk
Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase.

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All Publications

2012: William W Metcalf; David A Stahl; Robert M Cicchillo; Benjamin T Circello; Heather A Cooke; Bradley S Evans; Jiangtao Gao; Benjamin M Griffin; Sarath Chandra Janga; Willm Martens-Habbena; Wilfred Adrianus van der Donk
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.
Science (New York, N.Y.) 2012;337(6098):1104-7.
2012: Seung Young Kim; Tomohisa Kuzuyama; William W Metcalf; Bradley S Evans; Kou-San Ju; Wilfred Adrianus van der Donk
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.
Antimicrobial agents and chemotherapy 2012;56(8):4175-83.
2012: John E Hung; Tyler Johannes; William W Metcalf; Harry D Christman; Emily J Fogle; Huimin Zhao; Wilfred Adrianus van der Donk
Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase.
Biochemistry 2012;51(21):4254-62.
2012: Petra R A Kohler; William W Metcalf
Genetic manipulation of Methanosarcina spp.
Frontiers in microbiology 2012;3():259.
2011: Vinayak Agarwal; Svetlana A Borisova; William W Metcalf; Wilfred Adrianus van der Donk; Satish K Nair
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase.
Chemistry & biology 2011;18(10):1230-40.
2011: Benjamin T Circello; Jin-Hee Lee; Charles G Miller; Wilfred Adrianus van der Donk; William W Metcalf
The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica.
Antimicrobial agents and chemotherapy 2011;55(7):3357-62.
2011: Svetlana A Borisova; Harry D Christman; M E Mourey Metcalf; Wilfred Adrianus van der Donk; Jun Kai Zhang; Nurul A Zulkepli; William W Metcalf
Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021.
The Journal of biological chemistry 2011;286(25):22283-90.
2011: Bradley S Evans; Yunqiu Chen; William W Metcalf; Huimin Zhao; Neil L Kelleher
Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.
Chemistry & biology 2011;18(5):601-7.
2010: Jin-Hee Lee; Brian Bae; Michael Kuemin; Benjamin T Circello; William W Metcalf; Satish K Nair; Wilfred Adrianus van der Donk
Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17557-62.
2010: Ralph S Wolfe; William W Metcalf
A vacuum-vortex technique for preparation of anoxic solutions or liquid culture media in small volumes for cultivating methanogens or other strict anaerobes.
Anaerobe 2010;16(3):216-9.
2010: Benjamin T Circello; Andrew C Eliot; Jin-Hee Lee; Wilfred Adrianus van der Donk; William W Metcalf
Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster.
Chemistry & biology 2010;17(4):402-11.
2010: Nicole R Buan; William W Metcalf
Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.
Molecular microbiology 2010;75(4):843-53.
2010: Tyler Johannes; Matthew A DeSieno; Benjamin M Griffin; Paul M Thomas; Neil L Kelleher; William W Metcalf; Huimin Zhao
Deciphering the late biosynthetic steps of antimalarial compound FR-900098.
Chemistry & biology 2010;17(1):57-64.
2010: Svetlana A Borisova; Benjamin T Circello; Jun Kai Zhang; Wilfred Adrianus van der Donk; William W Metcalf
Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633.
Chemistry & biology 2010;17(1):28-37.
2009: Rina B Opulencia; Arpita Bose; William W Metcalf
Physiology and posttranscriptional regulation of methanol:coenzyme M methyltransferase isozymes in Methanosarcina acetivorans C2A.
Journal of bacteriology 2009;191(22):6928-35.
2009: Arpita Bose; Gargi Kulkarni; William W Metcalf
Regulation of putative methyl-sulphide methyltransferases in Methanosarcina acetivorans C2A.
Molecular microbiology 2009;74(1):227-38.
2009: Gargi Kulkarni; Donna M Kridelbaugh; Adam M Guss; William W Metcalf
Hydrogen is a preferred intermediate in the energy-conserving electron transport chain of Methanosarcina barkeri.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15915-20.
2009: Jonathan T Ferguson; Craig D Wenger; William W Metcalf; Neil L Kelleher
Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans.
Journal of the American Society for Mass Spectrometry 2009;20(9):1743-50.
2009: Kechao Yang; Mi Wang; William W Metcalf
Uptake of glycerol-2-phosphate via the ugp-encoded transporter in Escherichia coli K-12.
Journal of bacteriology 2009;191(14):4667-70.
2009: Robert M Cicchillo; Houjin Zhang; Joshua A V Blodgett; John T Whitteck; Gongyong Li; Satish K Nair; Wilfred Adrianus van der Donk; William W Metcalf
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.
Nature 2009;459(7248):871-4.
2009: Adam M Guss; Gargi Kulkarni; William W Metcalf
Differences in hydrogenase gene expression between Methanosarcina acetivorans and Methanosarcina barkeri.
Journal of bacteriology 2009;191(8):2826-33.
2009: William W Metcalf; Wilfred Adrianus van der Donk
Biosynthesis of phosphonic and phosphinic acid natural products.
Annual review of biochemistry 2009;78():65-94.
2008: Adam M Guss; Michael Rother; Jun Kai Zhang; Gargi Kulkarni; William W Metcalf
New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species.
Archaea (Vancouver, B.C.) 2008;2(3):193-203.
2008: Andrew C Eliot; Benjamin M Griffin; Paul M Thomas; Tyler Johannes; Neil L Kelleher; Huimin Zhao; William W Metcalf
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
Chemistry & biology 2008;15(8):765-70.
2008: Zengyi Shao; Joshua A V Blodgett; Benjamin T Circello; Andrew C Eliot; Ryan Woodyer; Gongyong Li; Wilfred Adrianus van der Donk; William W Metcalf; Huimin Zhao
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways.
The Journal of biological chemistry 2008;283(34):23161-8.
2008: Arpita Bose; Matthew A Pritchett; William W Metcalf
Genetic analysis of the methanol- and methylamine-specific methyltransferase 2 genes of Methanosarcina acetivorans C2A.
Journal of bacteriology 2008;190(11):4017-26.
2008: Paula V Welander; William W Metcalf
Mutagenesis of the C1 oxidation pathway in Methanosarcina barkeri: new insights into the Mtr/Mer bypass pathway.
Journal of bacteriology 2008;190(6):1928-36.
2008: Arpita Bose; William W Metcalf
Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
Molecular microbiology 2008;67(3):649-61.
2007: Joshua A V Blodgett; Paul M Thomas; Gongyong Li; Juan E Velasquez; Wilfred Adrianus van der Donk; Neil L Kelleher; William W Metcalf
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
Nature chemical biology 2007;3(8):480-5.
2007: Anirban Mahapatra; Gayathri Srinivasan; Kerstin B Richter; Andrew Meyer; Tanja Lienard; Jun Kai Zhang; Gang Zhao; Patrick T Kang; Michael Chan; Gerhard Gottschalk; William W Metcalf; Joseph A Krzycki
Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.
Molecular microbiology 2007;64(5):1306-18.
2007: Andrea K White; William W Metcalf
Microbial metabolism of reduced phosphorus compounds.
Annual review of microbiology 2007;61():379-400.
2007: John T Whitteck; Weijuan Ni; Benjamin M Griffin; Andrew C Eliot; Paul M Thomas; Neil L Kelleher; William W Metcalf; Wilfred Adrianus van der Donk
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid.
Angewandte Chemie (International ed. in English) 2007;46(47):9089-92.
2006: Ryan Woodyer; Zengyi Shao; Paul M Thomas; Neil L Kelleher; Joshua A V Blodgett; William W Metcalf; Wilfred Adrianus van der Donk; Huimin Zhao
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.
Chemistry & biology 2006;13(11):1171-82.
2006: Dennis L Maeder; Iain Anderson; Thomas S Brettin; David Bruce; Paul Gilna; Cliff S Han; Alla Lapidus; William W Metcalf; Elizabeth Saunders; Roxanne Tapia; Kevin R Sowers
The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes.
Journal of bacteriology 2006;188(22):7922-31.
2006: Arpita Bose; Matthew A Pritchett; Michael Rother; William W Metcalf
Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
Journal of bacteriology 2006;188(20):7274-83.
2006: Anirban Mahapatra; Asmita Patel; Jitesh A Soares; Ross C Larue; Jun Kai Zhang; William W Metcalf; Joseph A Krzycki
Characterization of a Methanosarcina acetivorans mutant unable to translate UAG as pyrrolysine.
Molecular microbiology 2006;59(1):56-66.
2006: Steven M Patrie; Jonathan T Ferguson; Dana E Robinson; Dave Whipple; Michael Rother; William W Metcalf; Neil L Kelleher
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation.
Molecular & cellular proteomics : MCP 2006;5(1):14-25.
2005: Michael Rother; William W Metcalf
Genetic technologies for Archaea.
Current opinion in microbiology 2005;8(6):745-51.
2005: Lucia Forzi; Jürgen Koch; Adam M Guss; Carl G Radosevich; William W Metcalf; Reiner Hedderich
Assignment of the [4Fe-4S] clusters of Ech hydrogenase from Methanosarcina barkeri to individual subunits via the characterization of site-directed mutants.
The FEBS journal 2005;272(18):4741-53.
2005: Michael Rother; Paolo Boccazzi; Arpita Bose; Matthew A Pritchett; William W Metcalf
Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A and allows isolation of mutants with defects in regulation of the methanol utilization pathway.
Journal of bacteriology 2005;187(16):5552-9.
2005: Paula V Welander; William W Metcalf
Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10664-9.
2005: Matthew A Pritchett; William W Metcalf
Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
Molecular microbiology 2005;56(5):1183-94.
2005: Adam M Guss; Biswarup Mukhopadhyay; Jun Kai Zhang; William W Metcalf
Genetic analysis of mch mutants in two Methanosarcina species demonstrates multiple roles for the methanopterin-dependent C-1 oxidation/reduction pathway and differences in H(2) metabolism between closely related species.
Molecular microbiology 2005;55(6):1671-80.
2005: Marlena M Wilson; William W Metcalf
Genetic diversity and horizontal transfer of genes involved in oxidation of reduced phosphorus compounds by Alcaligenes faecalis WM2072.
Applied and environmental microbiology 2005;71(1):290-6.
2005: Joshua A V Blodgett; Jun Kai Zhang; William W Metcalf
Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736.
Antimicrobial agents and chemotherapy 2005;49(1):230-40.
2004: Michael Rother; William W Metcalf
Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: an unusual way of life for a methanogenic archaeon.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16929-34.
2004: Andrea K White; William W Metcalf
The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the pho regulon.
Journal of bacteriology 2004;186(17):5876-82.
2004: Andrea K White; William W Metcalf
Two C-P lyase operons in Pseudomonas stutzeri and their roles in the oxidation of phosphonates, phosphite, and hypophosphite.
Journal of bacteriology 2004;186(14):4730-9.
2004: Kechao Yang; William W Metcalf
A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7919-24.
2004: Matthew A Pritchett; Jun Kai Zhang; William W Metcalf
Development of a markerless genetic exchange method for Methanosarcina acetivorans C2A and its use in construction of new genetic tools for methanogenic archaea.
Applied and environmental microbiology 2004;70(3):1425-33.
2002: Andrea K White; William W Metcalf
Isolation and biochemical characterization of hypophosphite/2-oxoglutarate dioxygenase. A novel phosphorus-oxidizing enzyme from Psuedomonas stutzeri WM88.
The Journal of biological chemistry 2002;277(41):38262-71.
2002: Jennifer M Vrtis; Andrea K White; William W Metcalf; Wilfred Adrianus van der Donk
Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme.
Angewandte Chemie (International ed. in English) 2002;41(17):3257-9.
2002: Rachel A Larsen; Marlena M Wilson; Adam M Guss; William W Metcalf
Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria.
Archives of microbiology 2002;178(3):193-201.
2002: Miriam K Sluis; Rachel A Larsen; Jonathan G Krum; Ruth Anderson; William W Metcalf; Scott A Ensign
Biochemical, molecular, and genetic analyses of the acetone carboxylases from Xanthobacter autotrophicus strain Py2 and Rhodobacter capsulatus strain B10.
Journal of bacteriology 2002;184(11):2969-77.
2002: Jörn Meuer; H Craig Kuettner; Jun Kai Zhang; Reiner Hedderich; William W Metcalf
Genetic analysis of the archaeon Methanosarcina barkeri Fusaro reveals a central role for Ech hydrogenase and ferredoxin in methanogenesis and carbon fixation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5632-7.
2002: Jun Kai Zhang; Andrea K White; H Craig Kuettner; Paolo Boccazzi; William W Metcalf
Directed mutagenesis and plasmid-based complementation in the methanogenic archaeon Methanosarcina acetivorans C2A demonstrated by genetic analysis of proline biosynthesis.
Journal of bacteriology 2002;184(5):1449-54.
2001: A M Costas; Andrea K White; William W Metcalf
Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88.
The Journal of biological chemistry 2001;276(20):17429-36.
2001: Jennifer M Vrtis; Andrea K White; William W Metcalf; Wilfred Adrianus van der Donk
Phosphite dehydrogenase: an unusual phosphoryl transfer reaction.
Journal of the American Chemical Society 2001;123(11):2672-3.
2000: Jun Kai Zhang; Matthew A Pritchett; David J Lampe; Hugh M Robertson; William W Metcalf
In vivo transposon mutagenesis of the methanogenic archaeon Methanosarcina acetivorans C2A using a modified version of the insect mariner-family transposable element Himar1.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9665-70.
2000: Paolo Boccazzi; Jun Kai Zhang; William W Metcalf
Generation of dominant selectable markers for resistance to pseudomonic acid by cloning and mutagenesis of the ileS gene from the archaeon Methanosarcina barkeri fusaro.
Journal of bacteriology 2000;182(9):2611-8.
1998: William W Metcalf; RS Wolfe
Molecular genetic analysis of phosphite and hypophosphite oxidation by Pseudomonas stutzeri WM88.
Journal of bacteriology 1998;180(21):5547-58.
1998: William W Metcalf; Jun Kai Zhang; RS Wolfe
An anaerobic, intrachamber incubator for growth of Methanosarcina spp. on methanol-containing solid media.
Applied and environmental microbiology 1998;64(2):768-70.
1997: William W Metcalf; Jun Kai Zhang; E Apolinario; Kevin R Sowers; RS Wolfe
A genetic system for Archaea of the genus Methanosarcina: liposome-mediated transformation and construction of shuttle vectors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2626-31.
1996: William W Metcalf; Jun Kai Zhang; X Shi; RS Wolfe
Molecular, genetic, and biochemical characterization of the serC gene of Methanosarcina barkeri Fusaro.
Journal of bacteriology 1996;178(19):5797-802.