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Ralf Metzger

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Gene Expression Regulation, Neoplastic

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Peter P Grimminger; Arnulf H Hölscher; Martin K H Maus; Ralf Metzger; Paul M Schneider; Hirofumi Sugita; Hakan Alakus; Peter V Danenberg; Jan Brabender
Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC.
Daniel Vallböhmer; I Wedemeyer; Elfriede Bollschweiler; Jan Brabender; P P Grimminger; C Gutschow; Arnulf H Hölscher; Ralf Metzger; W Schröder; Uta Drebber
Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
Elfriede Bollschweiler; Stephan E Baldus; Sarah Besch; Arnulf H Hölscher; Ralf Metzger; Stefan P Mönig; Uta Drebber
Prognostic significance of a new grading system of lymph node morphology after neoadjuvant radiochemotherapy for esophageal cancer.

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2012: Peter P Grimminger; Arnulf H Hölscher; Martin K H Maus; Ralf Metzger; Paul M Schneider; Hirofumi Sugita; Hakan Alakus; Peter V Danenberg; Jan Brabender
Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC.
Lung cancer (Amsterdam, Netherlands) 2012;78(1):87-91.
2012: Daniel Vallböhmer; I Wedemeyer; Elfriede Bollschweiler; Jan Brabender; P P Grimminger; C Gutschow; Arnulf H Hölscher; Ralf Metzger; W Schröder; Uta Drebber
Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
International journal of colorectal disease 2012;27(10):1295-301.
2011: Elfriede Bollschweiler; Stephan E Baldus; Sarah Besch; Arnulf H Hölscher; Ralf Metzger; Stefan P Mönig; Uta Drebber
Prognostic significance of a new grading system of lymph node morphology after neoadjuvant radiochemotherapy for esophageal cancer.
The Annals of thoracic surgery 2011;92(6):2020-7.
2011: Arnulf H Hölscher; Ralf Metzger; Wolfgang Schröder; Elfriede Bollschweiler; Christian Gutschow; Uta Drebber
Prognostic impact of upper, middle, and lower third mucosal or submucosal infiltration in early esophageal cancer.
Annals of surgery 2011;254(5):802-7; discussion 807-8.
2011: Paul M Schneider; Daniel Vallbohmer; Jan Brabender; Uta Drebber; Frederike C Ling; Georg Lurje; Ralf Metzger; Yvonne Ploenes; Arnulf H Hoelscher
Evaluation of quality indicators following implementation of total mesorectal excision in primarily resected rectal cancer changed future management.
International journal of colorectal disease 2011;26(7):903-9.
2011: Hans Theodor Eich; Anna Stepien; Christian Zimmermann; Martin Hellmich; Ralf Metzger; Arnulf Hölscher; Rolf-Peter Müller
Neoadjuvant radiochemotherapy and surgery for advanced rectal cancer : prognostic significance of tumor regression.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2011;187(4):225-30.
2011: Kosuke Narumiya; Ralf Metzger; Elfriede Bollschweiler; Hakan Alakus; Jan Brabender; Uta Drebber; Arnulf H Hölscher; Ute Warnecke-Eberz
Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer.
Pharmacogenomics 2011;12(2):205-14.
2010: Hakan Alakus; Noor Afriani; Ute Warnecke-Eberz; Elfriede Bollschweiler; Ulrich Fetzner; Uta Drebber; Ralf Metzger; Arnulf H Hölscher; Stefan P Mönig
Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.
World journal of surgery 2010;34(12):2853-9.
2010: Elfriede Bollschweiler; Sarah Besch; Uta Drebber; Wolfgang Schröder; Stefan P Mönig; Daniel Vallböhmer; Stephan E Baldus; Ralf Metzger; Arnulf H Hölscher
Influence of neoadjuvant chemoradiation on the number and size of analyzed lymph nodes in esophageal cancer.
Annals of surgical oncology 2010;17(12):3187-94.
2010: Ralf Metzger; Elfriede Bollschweiler; Arnulf H Hölscher; Ute Warnecke-Eberz
ERCC1: impact in multimodality treatment of upper gastrointestinal cancer.
Future oncology (London, England) 2010;6(11):1735-49.
2010: Peter P Grimminger; Jan Brabender; Ute Warnecke-Eberz; Kosuke Narumiya; Christoph Wandhöfer; Uta Drebber; Elfriede Bollschweiler; Arnulf H Hölscher; Ralf Metzger; Daniel Vallböhmer
XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer.
The Journal of surgical research 2010;164(1):e61-6.
2010: Peter P Grimminger; Paul M Schneider; Ralf Metzger; Daniel Vallböhmer; Kathleen D Danenberg; Peter V Danenberg; Arnulf H Hölscher; Jan Brabender
The prognostic role of Bcl-2 mRNA expression in curatively resected non-small cell lung cancer (NSCLC).
Lung cancer (Amsterdam, Netherlands) 2010;70(1):82-7.
2010: Peter P Grimminger; Paul M Schneider; Ralf Metzger; Daniel Vallböhmer; Arnulf H Hölscher; Peter V Danenberg; Jan Brabender
Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer.
Clinical lung cancer 2010;11(5):328-34.
2010: Ralf Metzger; Lukas Heukamp; Uta Drebber; Elfriede Bollschweiler; Thomas Zander; Arnulf H Hoelscher; Ute Warnecke-Eberz
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Pharmacogenomics 2010;11(8):1105-13.
2010: Daniel Vallböhmer; Arnulf H Hölscher; Paul M Schneider; Matthias Schmidt; Markus Dietlein; Elfriede Bollschweiler; S Baldus; Hakan Alakus; Jan Brabender; Ralf Metzger; Stefan P Mönig
[18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer.
Journal of surgical oncology 2010;102(2):135-40.
2010: Hakan Alakus; Mert Batur; Matthias Schmidt; Uta Drebber; Stephan E Baldus; Daniel Vallböhmer; Klaus L Prenzel; Ralf Metzger; Elfriede Bollschweiler; Arnulf H Hölscher; Stefan P Mönig
Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression.
Nuclear medicine communications 2010;31(6):532-8.
2010: Ralf Metzger; Elfriede Bollschweiler; Uta Drebber; Stefan P Mönig; Wolfgang Schröder; Hakan Alakus; Martin Kocher; Stephan E Baldus; Arnulf H Hölscher
Neoadjuvant chemoradiotherapy for esophageal cancer: impact on extracapsular lymph node involvement.
World journal of gastroenterology : WJG 2010;16(16):1986-92.
2010: Peter P Grimminger; Paul M Schneider; Ralf Metzger; Daniel Vallböhmer; Kathleen D Danenberg; Peter V Danenberg; Arnulf H Hölscher; Jan Brabender
Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer.
Clinical lung cancer 2010;11(2):114-9.
2010: Daniel Vallböhmer; Jan Brabender; Ralf Metzger; Arnulf H Hölscher
Genetics in the pathogenesis of esophageal cancer: possible predictive and prognostic factors.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010;14 Suppl 1():S75-80.
2010: Hakan Alakus; Arnulf H Hölscher; Guido Grass; Eva Hartmann; Christian Schulte; Uta Drebber; Stephan E Baldus; Elfriede Bollschweiler; Ralf Metzger; Stefan P Mönig
Extracapsular lymph node spread: a new prognostic factor in gastric cancer.
Cancer 2010;116(2):309-15.
2010: Elfriede Bollschweiler; Arnulf H Hölscher; Ralf Metzger
Histologic tumor type and the rate of complete response after neoadjuvant therapy for esophageal cancer.
Future oncology (London, England) 2010;6(1):25-35.
2010: Ute Warnecke-Eberz; Ralf Metzger; Elfriede Bollschweiler; Stephan E Baldus; Rolf P Mueller; Hans P Dienes; Arnulf H Hoelscher; Paul M Schneider
TaqMan low-density arrays and analysis by artificial neuronal networks predict response to neoadjuvant chemoradiation in esophageal cancer.
Pharmacogenomics 2010;11(1):55-64.
2009: Hakan Alakus; Stefan P Mönig; Ute Warnecke-Eberz; Gül Alakus; Günther Winde; Uta Drebber; Klaus J Schmitz; Kurt W Schmid; Kathrin Riemann; Winfried Siffert; Elfriede Bollschweiler; Arnulf H Hölscher; Ralf Metzger
Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer.
World journal of gastroenterology : WJG 2009;15(48):6061-7.
2009: Daniel Vallböhmer; Arnulf H Hölscher; Markus Dietlein; Elfriede Bollschweiler; Stephan E Baldus; Stefan P Mönig; Ralf Metzger; Harald Schicha; Matthias Schmidt
[18F]-Fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemoradiation in esophageal cancer.
Annals of surgery 2009;250(6):888-94.
2009: Ute Warnecke-Eberz; Elfriede Bollschweiler; Uta Drebber; Ralf Metzger; Stephan E Baldus; Arnulf H Hölscher; Stefan P Mönig
Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer.
Anticancer research 2009;29(11):4451-5.
2009: Peter Grimminger; Daniel Vallböhmer; Andreas Hoffmann; Christian Schulte; Elfriede Bollschweiler; Paul M Schneider; Arnulf H Hölscher; Ralf Metzger; Jan Brabender
Quantitative analysis of survivin RNA expression in blood as a non-invasive predictor of response to neoadjuvant radiochemotherapy in esophageal cancer.
Journal of surgical oncology 2009;100(6):447-51.
2009: A C Hoffmann; J T Kaifi; Daniel Vallböhmer; E Yekebas; P Grimminger; Jessica Leers; Jakob R Izbicki; Arnulf H Hölscher; Paul M Schneider; Ralf Metzger; Jan Brabender
Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer.
Journal of surgical oncology 2009;100(5):414-7.
2009: Jessica Leers; Carlo Vivaldi; Hartmut Schäfer; Marc Bludau; Jan Brabender; Georg Lurje; Till Herbold; Arnulf H Hölscher; Ralf Metzger
Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent.
Surgical endoscopy 2009;23(10):2258-62.
2009: Ute Warnecke-Eberz; Daniel Vallböhmer; Hakan Alakus; Fabian Kütting; Georg Lurje; Elfriede Bollschweiler; Anke Wienand-Dorweiler; Uta Drebber; Arnulf H Hölscher; Ralf Metzger
ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2009;13(8):1411-21.
2009: Daniel Vallböhmer; U Drebber; Paul M Schneider; S Baldus; Elfriede Bollschweiler; Jan Brabender; Ute Warnecke-Eberz; S Mönig; Arnulf H Hölscher; Ralf Metzger
Survivin expression in gastric cancer: Association with histomorphological response to neoadjuvant therapy and prognosis.
Journal of surgical oncology 2009;99(7):409-13.
2009: Hakan Alakus; Ute Warnecke-Eberz; Elfriede Bollschweiler; S P Mönig; Daniel Vallböhmer; Jan Brabender; U Drebber; Stephan E Baldus; K Riemann; W Siffert; Arnulf H Hölscher; Ralf Metzger
GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer.
The pharmacogenomics journal 2009;9(3):202-7.
2009: Jan Brabender; Dariusch Arbab; Xi Huan; Daniel Vallböhmer; Peter Grimminger; Frederike Ling; Susanne Neiss; Elfriede Bollschweiler; Paul M Schneider; Arnulf H Hölscher; Ralf Metzger
Death-associated protein kinase (DAPK) promoter methylation and response to neoadjuvant radiochemotherapy in esophageal cancer.
Annals of surgical oncology 2009;16(5):1378-83.
2009: Peter Grimminger; Frederike C Ling; Susanne Neiss; Daniel Vallböhmer; Georg Lurje; Paul M Schneider; Arnulf H Hölscher; Ralf Metzger; Jan Brabender
The role of the homeobox genes BFT and CDX2 in the pathogenesis of non-small cell lung cancer.
Anticancer research 2009;29(4):1281-6.
2009: Ralf Metzger; Daniel Vallbohmer; Carsten Müller-Tidow; Hiroshi Higashi; Elfriede Bollschweiler; Ute Warnecke-Eberz; Jan Brabender; Stephan E Baldus; Huan Xi; Wolfgang E Berdel; Hubert Serve; Arnulf H Hoelscher; Paul M Schneider
Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer.
Anticancer research 2009;29(4):1157-62.
2009: Andreas-Claudius Hoffmann; Jan Brabender; Ralf Metzger; Fredericke Ling; Ute Warnecke-Eberz; Georg Lurje; Arnulf H Hoelscher; Paul M Schneider; Daniel Vallböhmer
Dihydropyrimidine dehydrogenase mRNA expression in peripheral blood of rectal cancer patients is significantly associated with residual tumor and distant metastases following resection.
Journal of surgical oncology 2009;99(5):296-301.
2009: Ralf Metzger; Uta Drebber; Stephan E Baldus; Stefan P Mönig; Arnulf H Hölscher; Elfriede Bollschweiler
Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus.
Annals of surgical oncology 2009;16(2):447-53.
2009: Elfriede Bollschweiler; Ralf Metzger; Uta Drebber; S Baldus; Daniel Vallböhmer; Martin Kocher; Arnulf H Hölscher
Histological type of esophageal cancer might affect response to neo-adjuvant radiochemotherapy and subsequent prognosis.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(2):231-8.
2009: Peter P Grimminger; Jan Stöhlmacher; Daniel Vallböhmer; Paul M Schneider; Arnulf H Hölscher; Ralf Metzger; Peter V Danenberg; Jan Brabender
Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer.
Journal of oncology 2009;2009():139590.
2009: P Grimminger; Daniel Vallböhmer; M Bludau; Jan Brabender; Ralf Metzger; Arnulf H Hölscher
Successful management of esophageal perforation due to an aortic arch aneurysm replacement.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2009;22(5):471-4.
2008: Jan Brabender; Daniel Vallböhmer; Peter Grimminger; Andreas C Hoffmann; Frederike Ling; Georg Lurje; Elfriede Bollschweiler; Paul M Schneider; Arnulf H Hölscher; Ralf Metzger
ERCC1 RNA expression in peripheral blood predicts minor histopathological response to neoadjuvant radio-chemotherapy in patients with locally advanced cancer of the esophagus.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(11):1815-21.
2008: Daniel Vallböhmer; H E Marcus; Stephan E Baldus; Jan Brabender; Uta Drebber; Ralf Metzger; Arnulf H Hölscher; Paul M Schneider
Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors.
Oncology reports 2008;20(4):779-83.
2008: Andreas-Claudius Hoffmann; Ryutaro Mori; Daniel Vallbohmer; Jan Brabender; Uta Drebber; Stephan E Baldus; Ellen Klein; Mizutomo Azuma; Ralf Metzger; Christina Hoffmann; Arnulf H Hoelscher; Kathleen D Danenberg; Klaus L Prenzel; Peter V Danenberg
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(10):1674-81; discussion 1681-2.
2008: Ute Warnecke-Eberz; Elfriede Bollschweiler; Uta Drebber; Alexandra Pohl; Stephan E Baldus; Arnulf H Hoelscher; Ralf Metzger
Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases.
Oncology reports 2008;20(3):619-24.
2008: Elfriede Bollschweiler; Jonas Apitzsch; Jonas Apitsch; Rainer Obliers; Armin Koerfer; Stefan P Mönig; Ralf Metzger; Arnulf H Hölscher
Improving informed consent of surgical patients using a multimedia-based program? Results of a prospective randomized multicenter study of patients before cholecystectomy.
Annals of surgery 2008;248(2):205-11.
2008: Hakan Alakus; Guido Grass; J K Hennecken; Elfriede Bollschweiler; C Schulte; Uta Drebber; Stephan E Baldus; Ralf Metzger; Arnulf H Hölscher; Stefan P Mönig
Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer.
Histology and histopathology 2008;23(8):917-23.
2008: Andreas-Claudius Hoffmann; Ryutaro Mori; Daniel Vallbohmer; Jan Brabender; Ellen Klein; Uta Drebber; Stephan E Baldus; Janine Cooc; Mizutomo Azuma; Ralf Metzger; Arnulf H Hoelscher; Kathleen D Danenberg; Klaus L Prenzel; Peter V Danenberg
High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.
Neoplasia (New York, N.Y.) 2008;10(7):674-9.
2008: Daniel Vallböhmer; Elmar Kuhn; Ute Warnecke-Eberz; Jan Brabender; Andreas C Hoffmann; Ralf Metzger; Stephan E Baldus; Uta Drebber; Arnulf H Hoelscher; Paul M Schneider
Failure in downregulation of intratumoral survivin expression following neoadjuvant chemoradiation in esophageal cancer.
Pharmacogenomics 2008;9(6):681-90.
2008: Ute Warnecke-Eberz; Stephan E Baldus; Elfriede Bollschweiler; Arnulf H Hoelscher; Ralf Metzger
Up-regulation of survivin mRNA might be a marker for non-invasive detection of non-small cell lung cancer rather than for prognosis.
Anticancer research 2008;28(3A):1525-9.
2008: Ute Warnecke-Eberz; Klaus L Prenzel; Stephan E Baldus; Ralf Metzger; Hans P Dienes; Elfriede Bollschweiler; Arnulf H Hoelscher; Paul M Schneider
Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancer.
Pancreas 2008;36(2):173-7.
2008: Daniel Vallböhmer; Arnulf H Hölscher; Jan Brabender; Klaus L Prenzel; Christian A Gutschow; Wolfgang Schröder; Ralf Metzger; Elfriede Bollschweiler
Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2008;21(7):596-600.
2008: Daniel Vallböhmer; H E Marcus; Stephan E Baldus; Jan Brabender; Georg Lurje; Uta Drebber; Ralf Metzger; Arnulf H Hölscher; Paul M Schneider
Comparative analysis of four histopathological classification systems to discriminate benign and malignant behaviour in gastrointestinal stromal tumors.
Anticancer research 2008;28(1B):367-72.
2007: Georg Lurje; Daniel Vallbohmer; Peter H Collet; Huan Xi; Stephan E Baldus; Jan Brabender; Ralf Metzger; Michaela Heitmann; Susanne Neiss; Uta Drebber; Arnulf H Holscher; Paul M Schneider
COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2007;11(9):1105-11.
2007: Frederike C Ling; Stephan E Baldus; J Khochfar; Huan Xi; Susanne Neiss; Jan Brabender; Ralf Metzger; Uta Drebber; Hans P Dienes; Elfriede Bollschweiler; Arnulf H Hoelscher; Paul M Schneider
Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer.
Histopathology 2007;50(2):203-9.
2007: A-C Hoffmann; Ute Warnecke-Eberz; Thomas Luebke; Klaus L Prenzel; Ralf Metzger; M Heitmann; Susanne Neiss; Daniel Vallbohmer; Arnulf H Hoelscher; Paul M Schneider
Survivin mRNA in peripheral blood is frequently detected and significantly decreased following resection of gastrointestinal cancers.
Journal of surgical oncology 2007;95(1):51-4.
2006: Daniel Vallböhmer; Jan Brabender; Dongyun Yang; Paul M Schneider; Ralf Metzger; Kathleen D Danenberg; Arnulf H Hölscher; Peter V Danenberg
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
Clinical lung cancer 2006;8(1):39-44.
2006: Hiroshi Higashi; Daniel Vallböhmer; Ute Warnecke-Eberz; Shuichi Hokita; Huan Xi; Jan Brabender; Ralf Metzger; Stephan E Baldus; Shoji Natsugoe; Takashi Aikou; Arnulf H Hölscher; Paul M Schneider
Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancer.
Anticancer research 2006;26(3A):2143-7.
2006: Daniel Vallböhmer; Jan Brabender; Dong Yun Yang; Kathleen D Danenberg; Paul M Schneider; Ralf Metzger; Arnulf H Holscher; Peter V Danenberg
Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancer.
Clinical lung cancer 2006;7(5):332-7.
2005: Huan Xi; Stephan E Baldus; Ute Warnecke-Eberz; Jan Brabender; Susanne Neiss; Ralf Metzger; Frederike C Ling; Hans P Dienes; Elfriede Bollschweiler; Stefan P Moenig; Rolf-Peter Mueller; Arnulf H Hoelscher; Paul M Schneider
High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(23):8341-7.
2005: Paul M Schneider; Stephan E Baldus; Ralf Metzger; Martin Kocher; Rudolf Bongartz; Elfriede Bollschweiler; Hartmut Schaefer; Juergen Thiele; Hans P Dienes; Rolf-Peter Mueller; Arnulf H Hoelscher
Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification.
Annals of surgery 2005;242(5):684-92.
2005: Jan Brabender; Paul Marjoram; Reginald V N Lord; Ralf Metzger; Dennis Salonga; Daniel Vallböhmer; Hartmut Schäfer; Kathleen D Danenberg; Peter V Danenberg; Florin Selaru; Stephan E Baldus; Arnulf H Hölscher; Meltzer Stephen J.; Paul M Schneider
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(9):2113-7.
2005: Ute Warnecke-Eberz; Shuichi Hokita; Huan Xi; Hiroshi Higashi; Stephan E Baldus; Ralf Metzger; Jan Brabender; Elfriede Bollschweiler; Rolf-Peter Mueller; Hans P Dienes; Arnulf H Hoelscher; Paul M Schneider
Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer.
Oncology reports 2005;13(6):1241-6.
2005: Jan Brabender; Ralf Metzger; Dennis Salonga; Kathleen D Danenberg; Peter V Danenberg; Arnulf H Hölscher; Paul M Schneider
Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis.
Carcinogenesis 2005;26(3):525-30.
2004: Futoshi Miyazono; Ralf Metzger; Ute Warnecke-Eberz; Stephan E Baldus; Jan Brabender; Elfriede Bollschweiler; Walter Doerfler; Rolf-Peter Mueller; Hans P Dienes; Takashi Aikou; Arnulf H Hoelscher; Paul M Schneider
Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer.
British journal of cancer 2004;91(4):666-72.
2004: Arnulf H Hölscher; Ralf Metzger; Jan Brabender; Daniel Vallböhmer; Elfriede Bollschweiler
High-volume centers--effect of case load on outcome in cancer surgery.
Onkologie 2004;27(4):412-6.
2004: Jan Brabender; Paul Marjoram; Dennis Salonga; Ralf Metzger; Paul M Schneider; Ji Min Park; Sylke Schneider; Arnulf H Hölscher; Jing Yin; Meltzer Stephen J.; Kathleen D Danenberg; Peter V Danenberg; Reginald V N Lord
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus.
Oncogene 2004;23(27):4780-8.
2004: Ute Warnecke-Eberz; Ralf Metzger; Futoshi Miyazono; Stephan E Baldus; Susanne Neiss; Jan Brabender; Hartmut Schaefer; Walter Doerfler; Elfriede Bollschweiler; Hans P Dienes; Rolf-Peter Mueller; Peter V Danenberg; Arnulf H Hoelscher; Paul M Schneider
High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3794-9.
2004: Jan Brabender; Reginald V N Lord; Ralf Metzger; JiMin Park; Dennis Salonga; Kathleen D Danenberg; Arnulf H Hölscher; Peter V Danenberg; Paul M Schneider
Role of retinoid X receptor mRNA expression in Barrett's esophagus.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2004;8(4):413-22.
2004: Ralf Metzger; Paul M Schneider; Ute Warnecke-Eberz; Jan Brabender; Arnulf H Hölscher
Molecular biology of esophageal cancer.
Onkologie 2004;27(2):200-6.
2004: Sylke Schneider; Ji Min Yochim; Jan Brabender; Kazumi Uchida; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; Dennis Salonga; Arnulf H Hölscher; Peter V Danenberg
Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1588-96.
2004: Ralf Metzger; Elfriede Bollschweiler; Daniel Vallböhmer; M Maish; T R DeMeester; Arnulf H Hölscher
High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality?
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2004;17(4):310-4.
2003: Jan Brabender; Reginald V N Lord; Ralf Metzger; JiMin Park; Dennis Salonga; Kathleen D Danenberg; Peter V Danenberg; Arnulf H Hölscher; Paul M Schneider
Differential SPARC mRNA expression in Barrett's oesophagus.
British journal of cancer 2003;89(8):1508-12.
2003: Jan Brabender; Henning Usadel; Ralf Metzger; Paul M Schneider; JiMin Park; Dennis Salonga; Denice D Tsao-Wei; Susan Groshen; Reginald V N Lord; Naoko Takebe; Sylke Schneider; Arnulf H Hölscher; Kathleen D Danenberg; Peter V Danenberg
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):223-7.
2002: Futoshi Miyazono; Paul M Schneider; Ralf Metzger; Ute Warnecke-Eberz; Stephan E Baldus; Hans P Dienes; Takashi Aikou; Arnulf H Hoelscher
Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus.
Oncogene 2002;21(23):3780-3.
2002: Jan Brabender; Reginald V N Lord; Kumari Wickramasinghe; Ralf Metzger; Paul M Schneider; Ji-Min Park; Arnulf H Hölscher; Tom R DeMeester; Kathleen D Danenberg; Peter V Danenberg
Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2002;6(3):359-67.
2002: Jan Brabender; JiMin Park; Ralf Metzger; Paul M Schneider; Reginald V N Lord; Arnulf H Hölscher; Kathleen D Danenberg; Peter V Danenberg
Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer.
Annals of surgery 2002;235(3):440-3.
2002: Jan Brabender; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; Reginald V N Lord; Susan Groshen; Denice D Tsao-Wei; JiMin Park; Dennis Salonga; Arnulf H Hölscher; Peter V Danenberg
The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):438-43.
2001: Eva Wolfgarten; U Rosendahl; T Nowroth; Jessica Leers; Ralf Metzger; Arnulf H Hölscher; Elfriede Bollschweiler
Coincidence of nutritional habits and esophageal cancer in Germany.
Onkologie 2001;24(6):546-51.
2001: Jan Brabender; Reginald V N Lord; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; Ji-Min Park; Dennis Salonga; Susan Groshen; Denice D Tsao-Wei; Tom R DeMeester; Arnulf H Hölscher; Peter V Danenberg
Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.
The Journal of surgical research 2001;99(2):301-6.
2001: Jan Brabender; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; JiMin Park; Dennis Salonga; Arnulf H Hölscher; Peter V Danenberg
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1850-5.
2001: Jan Brabender; Henning Usadel; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; Reginald V N Lord; Kumari Wickramasinghe; C E Lum; J Park; Dennis Salonga; J Singer; David Sidransky; Arnulf H Hölscher; Meltzer Stephen J.; Peter V Danenberg
Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival.
Oncogene 2001;20(27):3528-32.
2001: Jan Brabender; Reginald V N Lord; Kathleen D Danenberg; Ralf Metzger; Paul M Schneider; Hiroyuki Uetake; K Kawakami; Ji-Min Park; Dennis Salonga; Jeffrey H Peters; Tom R DeMeester; Arnulf H Hölscher; Peter V Danenberg
Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2001;5(2):174-81; discussion 182.
2000: Paul M Schneider; H W Praeuer; O Stoeltzing; J Boehm; J Manning; Ralf Metzger; Ulrich Fink; S Wegerer; Arnulf H Hoelscher; J A Roth
Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer.
British journal of cancer 2000;83(4):473-9.
2000: Dennis Salonga; Kathleen D Danenberg; Martin R Johnson; Ralf Metzger; Susan Groshen; Denice D Tsao-Wei; Heinz-Josef Lenz; Cynthia G Leichman; Lawrence Leichman; R B Diasio; Peter V Danenberg
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1322-7.
2000: Arnulf H Hölscher; Ralf Metzger; Paul M Schneider
[Preoperative radiochemotherapy of esophageal carcinoma. Light at the end of the tunnel?].
Zentralblatt für Chirurgie 2000;125(4):319-25.
1998: Ralf Metzger; Kathleen D Danenberg; Cynthia G Leichman; Dennis Salonga; Edward L Schwartz; Scott Wadler; Heinz-Josef Lenz; Susan Groshen; Lawrence Leichman; Peter V Danenberg
High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2371-6.
1998: Heinz-Josef Lenz; Kazuhiko Hayashi; Dennis Salonga; Kathleen D Danenberg; Peter V Danenberg; Ralf Metzger; D Banerjee; J R Bertino; Susan Groshen; Lawrence Leichman; Cynthia G Leichman
p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1243-50.
1998: Ralf Metzger; Cynthia G Leichman; Kathleen D Danenberg; Peter V Danenberg; Heinz-Josef Lenz; Kazuhiko Hayashi; Susan Groshen; Dennis Salonga; H Cohen; L Laine; Peter F Crookes; Howard Silberman; Joaquina Baranda; B Konda; Lawrence Leichman
ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):309-16.
1997: Cynthia G Leichman; Heinz-Josef Lenz; Lawrence Leichman; Kathleen D Danenberg; Joaquina Baranda; Susan Groshen; William D Boswell; Ralf Metzger; M Tan; Peter V Danenberg
Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(10):3223-9.
1997: K Hayashi; Ralf Metzger; Dennis Salonga; Kathleen D Danenberg; Lawrence Leichman; U Fink; A Sendler; David P Kelsen; Gary K Schwartz; Susan Groshen; H J Lenz; Peter V Danenberg
High frequency of simultaneous loss of p16 and p16beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach.
Oncogene 1997;15(12):1481-8.