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Philip Meuleman

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Laura Icardi; Geert Leroux-Roels; Philip Meuleman; Raffaele Mori; Xavier Saelens; Michael Boutros; Karolien De Bosscher; Lode De Cauwer; Sven Eyckerman; Viola Gesellchen; Koen Vercauteren; Judith Verhelst; Jan Tavernier
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
Krzysztof Lacek; Geert Leroux-Roels; Philip Meuleman; Mariarosaria Naddeo; Thomas F Baumert; Riccardo Cortese; Samira Fafi-Kremer; Antonella Folgori; Katarzyna Grzyb; Arvind H Patel; Marek Patryk Słowikowski; Koen Vercauteren; Lieven Verhoye; Alfredo Nicosia
Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.
Philip Meuleman; Riccardo Cortese; Isabelle Desombere; Ali Farhoudi; Katarzyna Grzyb; Christopher T Jones; Geert Leroux-Roels; Charles M Rice; Timothy Sheahan; Lieven Verhoye; Maria Teresa Catanese; Alfredo Nicosia
A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo.

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All Publications

2012: Laura Icardi; Geert Leroux-Roels; Philip Meuleman; Raffaele Mori; Xavier Saelens; Michael Boutros; Karolien De Bosscher; Lode De Cauwer; Sven Eyckerman; Viola Gesellchen; Koen Vercauteren; Judith Verhelst; Jan Tavernier
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12058-63.
2012: Krzysztof Lacek; Geert Leroux-Roels; Philip Meuleman; Mariarosaria Naddeo; Thomas F Baumert; Riccardo Cortese; Samira Fafi-Kremer; Antonella Folgori; Katarzyna Grzyb; Arvind H Patel; Marek Patryk Słowikowski; Koen Vercauteren; Lieven Verhoye; Alfredo Nicosia
Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.
Journal of hepatology 2012;57(1):17-23.
2012: Philip Meuleman; Riccardo Cortese; Isabelle Desombere; Ali Farhoudi; Katarzyna Grzyb; Christopher T Jones; Geert Leroux-Roels; Charles M Rice; Timothy Sheahan; Lieven Verhoye; Maria Teresa Catanese; Alfredo Nicosia
A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo.
Hepatology (Baltimore, Md.) 2012;55(2):364-72.
2011: Sandra Ciesek; Che C Colpitts; Martina Friesland; Michael P Manns; Philip Meuleman; Michael Ott; Thomas Pietschmann; Luis M Schang; Jörg Steinmann; Thomas von Hahn; Heiner Wedemeyer; Eike Steinmann
The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry.
Hepatology (Baltimore, Md.) 2011;54(6):1947-55.
2011: Philip Meuleman; Kenneth E Palmer; Koen Vercauteren; Lieven Verhoye; Czeslaw Wychowski; Anna Albecka; Sandrine Belouzard; Geert Leroux-Roels; Jean Dubuisson
Griffithsin has antiviral activity against hepatitis C virus.
Antimicrobial agents and chemotherapy 2011;55(11):5159-67.
2011: Leen Lootens; Philip Meuleman; G Leroux-Roels; P Van Eenoo
Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice.
The Journal of steroid biochemistry and molecular biology 2011;127(3-5):374-81.
2011: Philip Meuleman; Jens Bukh; Lieven Verhoye; Ali Farhoudi; Thomas Vanwolleghem; Richard Y Wang; Isabelle Desombere; Harvey Alter; Robert H Purcell; Geert Leroux-Roels
In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus.
Hepatology (Baltimore, Md.) 2011;53(3):755-62.
2011: Patrick Maillard; Philip Meuleman; Eve-Isabelle Pécheur; Farzin Roohvand; Marine Walic; Thierry Huby; Wilfried Le Goff; Geert Leroux-Roels; Agata Budkowska
Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry.
PloS one 2011;6(10):e26637.
2010: Thomas Vanwolleghem; Louis Libbrecht; Bettina E Hansen; Isabelle Desombere; Tania Roskams; Philip Meuleman; Geert Leroux-Roels
Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice.
Journal of hepatology 2010;53(3):468-76.
2009: Leen Lootens; Peter Van Eenoo; Philip Meuleman; Oscar J Pozo; Pieter Van Renterghem; Geert Leroux-Roels; Frans T Delbeke
Steroid metabolism in chimeric mice with humanized liver.
Drug testing and analysis 2009;1(11-12):531-7.
2009: Philip Meuleman; Geert Leroux-Roels
HCV animal models: a journey of more than 30 years.
Viruses 2009;1(2):222-40.
2009: Thomas Pietschmann; Margarita Zayas; Philip Meuleman; Gang Long; Nicole Appel; George Koutsoudakis; Stephanie Kallis; Geert Leroux-Roels; Volker Lohmann; Ralf Bartenschlager
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations.
PLoS pathogens 2009;5(6):e1000475.
2008: Philip Meuleman; Joseph Hesselgesser; Matthew Paulson; Thomas Vanwolleghem; Isabelle Desombere; Hans Reiser; Geert Leroux-Roels
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo.
Hepatology (Baltimore, Md.) 2008;48(6):1761-8.
2008: Niki Vassilaki; Peter Friebe; Philip Meuleman; Stephanie Kallis; Artur Kaul; Glaucia Paranhos-Baccalà; Geert Leroux-Roels; Penelope Mavromara; Ralf Bartenschlager
Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication.
Journal of virology 2008;82(23):11503-15.
2008: Philip Meuleman; Geert Leroux-Roels
The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV.
Antiviral research 2008;80(3):231-8.
2008: Thomas Vanwolleghem; Jens Bukh; Philip Meuleman; Isabelle Desombere; Jean-Christophe Meunier; Harvey Alter; Robert Purcell; Geert Leroux-Roels
Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.
Hepatology (Baltimore, Md.) 2008;47(6):1846-55.
2008: Leen Lootens; Peter Van Eenoo; Philip Meuleman; Geert Leroux-Roels; Wim Van Thuyne; Frans T Delbeke
Development and validation of a quantitative gas chromatography-mass spectrometry method for the detection of endogenous androgens in mouse urine.
Journal of chromatography. A 2008;1178(1-2):223-30.
2007: Artur Kaul; Ilka Woerz; Philip Meuleman; Geert Leroux-Roels; Ralf Bartenschlager
Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant.
Journal of virology 2007;81(23):13168-79.
2007: Thomas Vanwolleghem; Philip Meuleman; Louis Libbrecht; Tania Roskams; Rita De Vos; Geert Leroux-Roels
Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse.
Gastroenterology 2007;133(4):1144-55.
2007: Joe Grove; Thierry Huby; Zania Stamataki; Thomas Vanwolleghem; Philip Meuleman; Michelle Farquhar; Anne Schwarz; Martine Moreau; James S Owen; Geert Leroux-Roels; Peter Balfe; Jane A McKeating
Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.
Journal of virology 2007;81(7):3162-9.
2006: Philip Meuleman; Sophia Steyaert; Louis Libbrecht; Sibyl Couvent; Freya Van Houtte; Filip Clinckspoor; Bernard De Hemptinne; Tania Roskams; Peter Vanlandschoot; Geert Leroux-Roels
Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection.
Clinica chimica acta; international journal of clinical chemistry 2006;366(1-2):156-62.
2006: Brett D Lindenbach; Philip Meuleman; Alexander Ploss; Thomas Vanwolleghem; Andrew J Syder; Jane A McKeating; Robert E Lanford; Stephen M Feinstone; Marian E Major; Geert Leroux-Roels; Charles M Rice
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3805-9.
2006: Philip Meuleman; Louis Libbrecht; Stefan Wieland; Rita De Vos; Nagy Habib; Anna Kramvis; Tania Roskams; Geert Leroux-Roels
Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus.
Journal of virology 2006;80(6):2797-807.
2005: Philip Meuleman; Louis Libbrecht; Rita De Vos; Bernard De Hemptinne; Kris Gevaert; Joël Vandekerckhove; Tania Roskams; Geert Leroux-Roels
Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera.
Hepatology (Baltimore, Md.) 2005;41(4):847-56.
2004: Isabelle Desombere; Philip Meuleman; H Rigole; Annick Willems; J Irsch; Geert Leroux-Roels
The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level.
Journal of immunological methods 2004;286(1-2):167-85.
2003: Philip Meuleman; Peter Vanlandschoot; Geert Leroux-Roels
A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice.
Biochemical and biophysical research communications 2003;308(2):375-8.
2001: Tinghua Cao; Philip Meuleman; Isabelle Desombere; Matti Sällberg; Geert Leroux-Roels
In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.
Journal of virology 2001;75(23):11449-56.
2001: Geert Leroux-Roels; Tinghua Cao; A De Knibber; Philip Meuleman; Annelies Roobrouck; Ali Farhoudi; Peter Vanlandschoot; Isabelle Desombere
Prevention of hepatitis B infections: vaccination and its limitations.
Acta clinica Belgica 2001;56(4):209-19.
1998: KURT TOURNOY; S Depraetere; Philip Meuleman; Geert Leroux-Roels; Romain A Pauwels
Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice.
European journal of immunology 1998;28(10):3221-30.