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Philip Beachy

Research Profile

Chemicals & Drugs

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Publications

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James Kim; Jynho Kim; Emily M King; Alex H Lee; Melika Rezaee; Gregory J Riggins; Blake T Aftab; Philip A Beachy; Alexandra Borodovsky; Baozhi Chen; Ervin H Epstein; Daniel Kim; Jean Y Tang; Charles M Rudin
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
Adrian Creanga; Thomas D Glenn; Randall K Mann; Adam M Saunders; William S Talbot; Philip A Beachy
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
Min-Sung Kim; Philip A Beachy; Brent Y Hamaoka; Adam M Saunders; Daniel J Leahy
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.

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All Publications

2013: James Kim; Jynho Kim; Emily M King; Alex H Lee; Melika Rezaee; Gregory J Riggins; Blake T Aftab; Philip A Beachy; Alexandra Borodovsky; Baozhi Chen; Ervin H Epstein; Daniel Kim; Jean Y Tang; Charles M Rudin
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
Cancer cell 2013;23(1):23-34.
2012: Adrian Creanga; Thomas D Glenn; Randall K Mann; Adam M Saunders; William S Talbot; Philip A Beachy
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
Genes & development 2012;26(12):1312-25.
2011: Min-Sung Kim; Philip A Beachy; Brent Y Hamaoka; Adam M Saunders; Daniel J Leahy
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13112-7.
2008: Jason S McLellan; Xiaoyan Zheng; Glenn Hauk; Rodolfo Ghirlando; Philip A Beachy; Daniel J Leahy
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.
Nature 2008;455(7215):979-83.
2007: Jantje M Gerdes; Yangfan Liu; Norann Zaghloul; Carmen C Leitch; Shaneka S Lawson; Masaki Kato; Philip A Beachy; Philip L Beales; George N DeMartino; Shannon Fisher; Jose L Badano; Nicholas Katsanis
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.
Nature genetics 2007;39(11):1350-60.
2007: CRAIG PEACOCK; Qiuju Wang; Gregory S Gesell; Ian M Corcoran-Schwartz; Evan Jones; Jynho Kim; Wendy L Devereux; Jonathan T Rhodes; Carol Ann Huff; Philip A Beachy; DAVID WATKINS; William Matsui
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4048-53.
2006: Jason S McLellan; Shenqin Yao; Xiaoyan Zheng; Brian V Geisbrecht; Rodolfo Ghirlando; Philip A Beachy; Daniel J Leahy
Structure of a heparin-dependent complex of Hedgehog and Ihog.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17208-13.
2006: Christophe Echeverri; Philip A Beachy; Buzz Baum; Michael Boutros; Frank Buchholz; Sumit K Chanda; Julian Downward; Jan Ellenberg; Andrew G Fraser; Nir Hacohen; William C Hahn; Aimee L Jackson; Amy Kiger; Peter Linsley; Lawrence Lum; Yong Ma; Bernard Mathey-Prévôt; David E Root; David M Sabatini; Jussi Taipale; Norbert Perrimon; René Bernards
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods 2006;3(10):777-9.
2006: Yong Ma; Andreea A Creanga; Lawrence Lum; Philip A Beachy
Prevalence of off-target effects in Drosophila RNA interference screens.
Nature 2006;443(7109):359-63.
2006: Silke Dorner; Lawrence Lum; Michelle Kim; Renato Paro; Philip A Beachy; Rachel Green
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11880-5.
2006: Shenqin Yao; Lawrence Lum; Philip A Beachy
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
Cell 2006;125(2):343-57.
2006: Randall J Roper; Laura L Baxter; Nidhi G Saran; Donna K Klinedinst; Philip A Beachy; Roger H Reeves
Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1452-6.
2005: Tapan Maity; Naoyuki Fuse; Philip A Beachy
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17026-31.
2004: Chi Zhang; Elizabeth H Williams; Yurong Guo; Lawrence Lum; Philip A Beachy
Extensive phosphorylation of Smoothened in Hedgehog pathway activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):17900-7.
2004: Philip A Beachy; Sunil S Karhadkar; berman david
Tissue repair and stem cell renewal in carcinogenesis.
Nature 2004;432(7015):324-31.
2004: Andrew R Hallahan; Joel I Pritchard; Stacey Hansen; Mark Benson; Jennifer Stoeck; Beryl A Hatton; Thomas L Russell; Richard G Ellenbogen; Irwin D Bernstein; Philip A Beachy; James M Olson
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
Cancer research 2004;64(21):7794-800.
2004: Sunil S Karhadkar; G Steven Bova; Nadia Abdallah; Surajit Dhara; Dale Gardner; Anirban Maitra; John T Isaacs; berman david; Philip A Beachy
Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Nature 2004;431(7009):707-12.
2004: Philip A Beachy; Sunil S Karhadkar; berman david
Mending and malignancy.
Nature 2004;431(7007):402.
2004: Lawrence Lum; Philip A Beachy
The Hedgehog response network: sensors, switches, and routers.
Science (New York, N.Y.) 2004;304(5678):1755-9.
2004: berman david; Nishita Desai; Xi Wang; Sunil S Karhadkar; Melissa Reynon; Cory Abate-Shen; Philip A Beachy; Michael M Shen
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis.
Developmental biology 2004;267(2):387-98.
2004: Randall K Mann; Philip A Beachy
Novel lipid modifications of secreted protein signals.
Annual review of biochemistry 2004;73():891-923.
2003: Lawrence Lum; Chi Zhang; Sekyung Oh; Randall K Mann; Doris P Von Kessler; Jussi Taipale; Frances Weis-Garcia; Ruoyu Gong; Baolin Wang; Philip A Beachy
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
Molecular cell 2003;12(5):1261-74.
2003: berman david; Sunil S Karhadkar; Anirban Maitra; Rocio Montes De Oca; Meg R Gerstenblith; Kimberly Briggs; Antony R Parker; Yutaka Shimada; James R Eshleman; DAVID WATKINS; Philip A Beachy
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
Nature 2003;425(6960):846-51.
2003: Michael K Cooper; Christopher A Wassif; Patrycja A Krakowiak; Jussi Taipale; Ruoyu Gong; Richard I Kelley; Forbes D Porter; Philip A Beachy
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Nature genetics 2003;33(4):508-13.
2003: Lawrence Lum; Shenqin Yao; Brian Mozer; Alessandra C Rovescalli; Doris P Von Kessler; Marshall Nirenberg; Philip A Beachy
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.
Science (New York, N.Y.) 2003;299(5615):2039-45.
2003: DAVID WATKINS; berman david; Scott G Burkholder; Baolin Wang; Philip A Beachy; Stephen B Baylin
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Nature 2003;422(6929):313-7.
2002: James Kenneth Chen; Jussi Taipale; Michael K Cooper; Philip A Beachy
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Genes & development 2002;16(21):2743-8.
2002: James Kenneth Chen; Jussi Taipale; Keith E Young; Tapan Maiti; Philip A Beachy
Small molecule modulation of Smoothened activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14071-6.
2002: Yong Ma; Alfrun Erkner; Ruoyu Gong; Shenqin Yao; Jussi Taipale; Konrad Basler; Philip A Beachy
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Cell 2002;111(1):63-75.
2002: berman david; Sunil S Karhadkar; Andrew R Hallahan; Joel I Pritchard; Charles G Eberhart; DAVID WATKINS; James Kenneth Chen; Michael K Cooper; Jussi Taipale; James M Olson; Philip A Beachy
Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science (New York, N.Y.) 2002;297(5586):1559-61.
2002: Jussi Taipale; Michael K Cooper; Tapan Maiti; Philip A Beachy
Patched acts catalytically to suppress the activity of Smoothened.
Nature 2002;418(6900):892-7.
2001: Z Chamoun; Randall K Mann; Denise Nellen; Doris P Von Kessler; Manolo Bellotto; Philip A Beachy; Konrad Basler
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
Science (New York, N.Y.) 2001;293(5537):2080-4.
2001: Chin Chiang; Ying Litingtung; Matthew P Harris; BK Simandl; Yina Li; Philip A Beachy; John Fallon
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
Developmental biology 2001;236(2):421-35.
2001: Jussi Taipale; Philip A Beachy
The Hedgehog and Wnt signalling pathways in cancer.
Nature 2001;411(6835):349-54.
2001: I Muñoz-Sanjuán; Michael K Cooper; Philip A Beachy; John Fallon; Jeremy Nathans
Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;220(3):238-45.
2000: Randall K Mann; Philip A Beachy
Cholesterol modification of proteins.
Biochimica et biophysica acta 2000;1529(1-3):188-202.
2000: Jussi Taipale; James Kenneth Chen; Michael K Cooper; B Wang; Randall K Mann; L Milenkovic; M P Scott; Philip A Beachy
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Nature 2000;406(6799):1005-9.
2000: B Wang; John Fallon; Philip A Beachy
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
Cell 2000;100(4):423-34.
1999: N Fuse; Tapan Maiti; B Wang; JA Porter; TM Hall; Daniel J Leahy; Philip A Beachy
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10992-9.
1999: C H Chen; Doris P Von Kessler; W Park; B Wang; Yong Ma; Philip A Beachy
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.
Cell 1999;98(3):305-16.
1999: Chin Chiang; R Z Swan; Marina Grachtchouk; M Bolinger; Ying Litingtung; E K Robertson; Michael K Cooper; W Gaffield; Heiner Westphal; Philip A Beachy; Andrzej Dlugosz
Essential role for Sonic hedgehog during hair follicle morphogenesis.
Developmental biology 1999;205(1):1-9.
1998: Michael K Cooper; JA Porter; Keith E Young; Philip A Beachy
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Science (New York, N.Y.) 1998;280(5369):1603-7.
1998: J L Rubenstein; Philip A Beachy
Patterning of the embryonic forebrain.
Current opinion in neurobiology 1998;8(1):18-26.
1997: TM Hall; JA Porter; Keith E Young; E V Koonin; Philip A Beachy; Daniel J Leahy
Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Cell 1997;91(1):85-97.
1997: Philip A Beachy; Michael K Cooper; Keith E Young; Doris P Von Kessler; W J Park; TM Hall; Daniel J Leahy; JA Porter
Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.
Cold Spring Harbor symposia on quantitative biology 1997;62():191-204.
1996: JA Porter; Keith E Young; Philip A Beachy
Cholesterol modification of hedgehog signaling proteins in animal development.
Science (New York, N.Y.) 1996;274(5285):255-9.
1996: Chin Chiang; Ying Litingtung; E Lee; Keith E Young; Jeffry L Corden; Heiner Westphal; Philip A Beachy
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Nature 1996;383(6599):407-13.
1996: JA Porter; S C Ekker; W J Park; Doris P Von Kessler; Keith E Young; C H Chen; Y Ma; Amina S Woods; Robert J Cotter; E V Koonin; Philip A Beachy
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
Cell 1996;86(1):21-34.
1996: A Szakmary; S M Huang; David T Chang; Philip A Beachy; M Sander
Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1607-12.
1995: T M Hall; JA Porter; Philip A Beachy; Daniel J Leahy
A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog.
Nature 1995;378(6553):212-6.
1995: Chin Chiang; Keith E Young; Philip A Beachy
Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex.
Development (Cambridge, England) 1995;121(11):3901-12.
1995: C J Lai; S C Ekker; Philip A Beachy; Randall T Moon
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage.
Development (Cambridge, England) 1995;121(8):2349-60.
1995: S C Ekker; L L McGrew; C J Lai; J J Lee; Doris P Von Kessler; Randall T Moon; Philip A Beachy
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.
Development (Cambridge, England) 1995;121(8):2337-47.
1995: S C Ekker; A R Ungar; P Greenstein; Doris P Von Kessler; JA Porter; Randall T Moon; Philip A Beachy
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.
Current biology : CB 1995;5(8):944-55.
1995: Mary Hynes; JA Porter; Chin Chiang; D Chang; Marc Tessier-Lavigne; Philip A Beachy; Arnon Rosenthal
Induction of midbrain dopaminergic neurons by Sonic hedgehog.
Neuron 1995;15(1):35-44.
1995: A López-Martínez; David T Chang; Chin Chiang; JA Porter; Maria A Ros; BK Simandl; Philip A Beachy; John Fallon
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.
Current biology : CB 1995;5(7):791-6.
1995: Chen-Ming Fan; JA Porter; Chin Chiang; David T Chang; Philip A Beachy; Marc Tessier-Lavigne
Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway.
Cell 1995;81(3):457-65.
1995: H Roelink; JA Porter; Chin Chiang; Y Tanabe; David T Chang; Philip A Beachy; Thomas M Jessell
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.
Cell 1995;81(3):445-55.
1995: JA Porter; Doris P Von Kessler; S C Ekker; Keith E Young; J J Lee; Kevin Moses; Philip A Beachy
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
Nature 1995;374(6520):363-6.
1995: B Sun; D A Hursh; D Jackson; Philip A Beachy
Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.
The EMBO journal 1995;14(3):520-35.
1994: J J Lee; S C Ekker; Doris P Von Kessler; JA Porter; B I Sun; Philip A Beachy
Autoproteolysis in hedgehog protein biogenesis.
Science (New York, N.Y.) 1994;266(5190):1528-37.
1994: Chin Chiang; Nipam H Patel; Keith E Young; Philip A Beachy
The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells.
Development (Cambridge, England) 1994;120(12):3581-93.
1994: David T Chang; A López; Doris P Von Kessler; Chin Chiang; BK Simandl; R Zhao; Michael F Seldin; John Fallon; Philip A Beachy
Products, genetic linkage and limb patterning activity of a murine hedgehog gene.
Development (Cambridge, England) 1994;120(11):3339-53.
1994: Chin Chiang; Philip A Beachy
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
Mechanisms of development 1994;47(3):225-39.
1994: S C Ekker; D G Jackson; Doris P Von Kessler; B I Sun; Keith E Young; Philip A Beachy
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
The EMBO journal 1994;13(15):3551-60.
1993: C Ma; Y Zhou; Philip A Beachy; Kevin Moses
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.
Cell 1993;75(5):927-38.
1993: Philip A Beachy; J Varkey; Keith E Young; Doris P Von Kessler; B I Sun; S C Ekker
Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites.
Molecular and cellular biology 1993;13(11):6941-56.
1992: S C Ekker; Doris P Von Kessler; Philip A Beachy
Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.
The EMBO journal 1992;11(11):4059-72.
1992: J J Lee; Doris P Von Kessler; S Parks; Philip A Beachy
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.
Cell 1992;71(1):33-50.
1991: S C Ekker; Keith E Young; Doris P Von Kessler; Philip A Beachy
Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.
The EMBO journal 1991;10(5):1179-86.
1990: Philip A Beachy
A molecular view of the Ultrabithorax homeotic gene of Drosophila.
Trends in genetics : TIG 1990;6(2):46-51.