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James Beadle

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
47
Hostetler, Karl
20
Aldern, Kathy
18
Kern, Earl
11
Hartline, Caroll
11
Wan, William
9
Gardner, Michael
8
Kini, GD
7
Freeman, William
7
Cheng, Lingyun
7
Trahan, Julissa
6
Ciesla, Stephanie
6
Keith, Kathy
5
Korba, Brent
5
Richman, Douglas
4
Quenelle, Debra

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Publications

TOP 3
Botros Sanaa S; William Samia; Beadle James R; Valiaeva Nadejda; Hostetler Karl Y
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(s)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Morrey John D; Korba Brent E; Beadle James R; Wyles David L; Hostetler Karl Y
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Wyles David L; Kaihara Kelly A; Korba Brent E; Schooley Robert T; Beadle James R; Hostetler Karl Y
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.

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All Publications

2009: Botros Sanaa S; William Samia; Beadle James R; Valiaeva Nadejda; Hostetler Karl Y
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(s)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Antimicrobial agents and chemotherapy 2009;53(12):5284-7.
2009: Morrey John D; Korba Brent E; Beadle James R; Wyles David L; Hostetler Karl Y
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Antimicrobial agents and chemotherapy 2009;53(7):2865-70.
2009: Wyles David L; Kaihara Kelly A; Korba Brent E; Schooley Robert T; Beadle James R; Hostetler Karl Y
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Antimicrobial agents and chemotherapy 2009;53(6):2660-2.
2008: Prichard Mark N; Hartline Caroll B; Harden Emma A; Daily Shannon L; Beadle James R; Valiaeva Nadejda; Kern Earl R; Hostetler Karl Y
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2008;52(12):4326-30.
2008: Quenelle Debra C; Collins Deborah J; Pettway Latisha R; Hartline Caroll B; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Antiviral research 2008;79(2):133-5.
2008: Randhawa Parmjeet; Zemlicka Jiri; Sauerbrei Andreas; Meier Chris; Hostetler Karl Y; Beadle James R; Farasati Noush Afarin; Huang Yuchen; Bradley Matthews
Anti-BK virus activity of nucleoside analogs.
Antimicrobial agents and chemotherapy 2008;52(4):1519-21.
2007: Quenelle Debra C; Collins Deborah J; Herrod Bridgett P; Keith Kathy A; Trahan Julissa; Beadle James R; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(11):3940-7.
2007: Tammewar Ajay M; Cheng Lingyun; Hostetler Karl Y; Falkenstein Iryna; Beadle James R; Barron Erin C; Kozak Igor; Freeman William R
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(5):433-44.
2007: Painter George R; Almond Merrick R; Trost Lawrence C; Lampert Bernhard M; Neyts Johan; De Clercq Erik; Korba Brent E; Aldern Kathy A; Beadle James R; Hostetler Karl Y
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Antimicrobial agents and chemotherapy 2007;51(10):3505-9.
2007: Ruiz Jacqueline C; Beadle James R; Aldern Kathy A; Keith Kathy A; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Antiviral research 2007;75(1):87-90.
2007: Dal Pozzo Fabiana; Andrei Graciela; Lebeau Ilya; Beadle James R; Hostetler Karl Y; De Clercq Erik; Snoeck Robert
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
Antiviral research 2007;75(1):52-7.
2007: Beadle James R
Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2007;Chapter 15():Unit 15.2.
2007: Hostetler Karl Y; Beadle James R; Trahan Julissa; Aldern Kathy A; Owens Gelita; Schriewer Jill; Melman Lora; Buller R Mark
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
Antiviral research 2007;73(3):212-8.
2007: Choo Hyunah; Beadle James R; Chong Youhoon; Trahan Julissa; Hostetler Karl Y
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.
Bioorganic & medicinal chemistry 2007;15(4):1771-9.
2007: Choo Hyunah; Beadle James R; Kern Earl R; Prichard Mark N; Keith Kathy A; Hartline Caroll B; Trahan Julissa; Aldern Kathy A; Korba Brent E; Hostetler Karl Y
Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
Antimicrobial agents and chemotherapy 2007;51(2):611-5.
2006: Valiaeva Nadejda; Beadle James R; Aldern Kathy A; Trahan Julissa; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.
Antiviral research 2006;72(1):10-9.
2006: Hostetler Karl Y; Aldern Kathy A; Wan William B; Ciesla Stephanie L; Beadle James R
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
Antimicrobial agents and chemotherapy 2006;50(8):2857-9.
2006: Lebeau Ilya; Andrei Graciela; Dal Pozzo Fabiana; Beadle James R; Hostetler Karl Y; De Clercq Erik; van den Oord Joost; Snoeck Robert
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.
Antimicrobial agents and chemotherapy 2006;50(7):2525-9.
2006: Beadle James R; Wan William B; Ciesla Stephanie L; Keith Kathy A; Hartline Caroll; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Journal of medicinal chemistry 2006;49(6):2010-5.
2006: Hostetler Karl Y; Rought Steffney; Aldern Kathy A; Trahan Julissa; Beadle James R; Corbeil Jacques
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.
Molecular cancer therapeutics 2006;5(1):156-9.
2006: Ruiz Jacqueline C; Aldern Kathy A; Beadle James R; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.
Antiviral chemistry & chemotherapy 2006;17(2):89-95.
2005: Williams-Aziz Stephanie L; Hartline Caroll B; Harden Emma A; Daily Shannon L; Prichard Mark N; Kushner Nicole L; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
Antimicrobial agents and chemotherapy 2005;49(9):3724-33.
2005: Lu Stephanie; Cheng Lingyun; Hostetler Karl Y; Koh Hyoung Jun; Beadle James R; Davidson Marie C; Freeman W R
Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005;21(3):205-9.
2005: Wan William B; Beadle James R; Hartline Caroll; Kern Earl R; Ciesla Stephanie L; Valiaeva Nadejda; Hostetler Karl Y
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
Antimicrobial agents and chemotherapy 2005;49(2):656-62.
2005: Hartline Caroll B; Gustin Kortney M; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
The Journal of infectious diseases 2005;191(3):396-9.
2004: Cheng Lingyun; Hostetler Karl Y; Lee Jeffery; Koh Hyoung Jun; Beadle James R; Bessho Kenichiro; Toyoguchi Mitsuko; Aldern Kathy; Bovet Jean-Marc; Freeman William R
Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
Investigative ophthalmology & visual science 2004;45(11):4138-44.
2004: Kern Earl R; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Quenelle Debra C
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(9):3516-22.
2004: Bidanset Deborah J; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
The Journal of infectious diseases 2004;190(3):499-503.
2004: Smee Donald F; Wong Min-Hui; Bailey Kevin W; Beadle James R; Hostetler Karl Y; Sidwell Robert W
Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.
International journal of antimicrobial agents 2004;23(5):430-7.
2004: Keith Kathy A; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
Antimicrobial agents and chemotherapy 2004;48(5):1869-71.
2004: Quenelle Debra C; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Kern Earl R
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(2):404-12.
2004: Buller R Mark; Owens Gelita; Schriewer Jill; Melman Lora; Beadle James R; Hostetler Karl Y
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.
Virology 2004;318(2):474-81.
2003: Ciesla Stephanie L; Trahan Julissa; Wan W Brad; Beadle James R; Aldern Kathy A; Painter George R; Hostetler Karl Y
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
Antiviral research 2003;59(3):163-71.
2003: Cheng Lingyun; Hostetler Karl Y; Toyoguchi Mitsuko; Beadle James R; Rodanant Nuttawut; Gardner Michael F; Aldern Kathy A; Bergeron-Lynn Germaine; Freeman William R
Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2003;19(2):161-9.
2002: Beadle James R; Hartline Caroll; Aldern Kathy A; Rodriguez Natalie; Harden Emma; Kern Earl R; Hostetler Karl Y
Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.
Antimicrobial agents and chemotherapy 2002;46(8):2381-6.
2002: Kern Earl R; Hartline Caroll; Harden Emma; Keith Kathy; Rodriguez Natalie; Beadle James R; Hostetler Karl Y
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
Antimicrobial agents and chemotherapy 2002;46(4):991-5.
2002: Cheng Lingyun; Hostetler Karl Y; Chaidhawangul Sunan; Gardner Michael F; Beadle James R; Toyoguchi Mitsuko; Bergeron-Lynn Germaine; Freeman William R
Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
Investigative ophthalmology & visual science 2002;43(2):515-21.
2001: Hammond J L; Koontz D L; Bazmi H Z; Beadle J R; Hostetler S E; Kini G D; Aldern K A; Richman D D; Hostetler K Y; Mellors J W
Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance.
Antimicrobial agents and chemotherapy 2001;45(6):1621-8.
2001: Hostetler K Y; Rybak R J; Beadle J R; Gardner M F; Aldern K A; Wright K N; Kern E R
In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.
Antiviral chemistry & chemotherapy 2001;12(1):61-70.
2000: Hostetler K Y; Beadle J R; Hornbuckle W E; Bellezza C A; Tochkov I A; Cote P J; Gerin J L; Korba B E; Tennant B C
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy 2000;44(7):1964-9.
2000: Hostetler K Y; Hammond J L; Kini G D; Hostetler S E; Beadle J R; Aldern K A; Chou T C; Richman D D; Mellors J W
In vitro anti-HIV-1 activity of sn-2-substituted 1-O-octadecyl-sn-glycero-3-phosphonoformate analogues and synergy with zidovudine.
Antiviral chemistry & chemotherapy 2000;11(3):213-9.
2000: Cheng L; Hostetler K Y; Chaidhawangul S; Gardner M F; Beadle J R; Keefe K S; Bergeron-Lynn G; Severson G M; Soules K A; Mueller A J; Freeman W R
Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.
Investigative ophthalmology & visual science 2000;41(6):1523-32.
2000: Beadle J R; Kini G D; Aldern K A; Gardner M F; Wright K N; Rybak R J; Kern E R; Hostetler K Y
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):471-9.
1999: Cheng L; Hostetler K Y; Gardner M F; Avila C P; Bergeron-Lynn G; Keefe K S; Beadle J R; Wiley C A; Freeman W R
Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1999;15(4):363-77.
1998: Beadle J R; Kini G D; Aldern K A; Gardner M F; Wright K N; Richman D D; Hostetler K Y
Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells.
Antiviral chemistry & chemotherapy 1998;9(1):33-40.
1997: Kini G D; Hostetler S E; Beadle J R; Aldern K A
Synthesis and antiviral activity of 1-O-octadecyl-2-O-alkyl-sn-glycero-3-foscarnet conjugates in human cytomegalovirus-infected cells.
Antiviral research 1997;36(2):115-24.
1997: Kini G D; Beadle J R; Xie H; Aldern K A; Richman D D; Hostetler K Y
Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.
Antiviral research 1997;36(1):43-53.
1997: Hostetler K Y; Beadle J R; Kini G D; Gardner M F; Wright K N; Wu T H; Korba B A
Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro.
Biochemical pharmacology 1997;53(12):1815-22.
1996: Hostetler K Y; Kini G D; Beadle J R; Aldern K A; Gardner M F; Border R; Kumar R; Barshak L; Sridhar C N; Wheeler C J; Richman D D
Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro.
Antiviral research 1996;31(1-2):59-67.

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