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Urs Meyer

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Urs A Meyer; Ulrich M Zanger; Matthias Schwab
Omics and drug response.
Adrian Roth; Renate Looser; Michel Kaufmann; Urs A Meyer
Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
Adrian Roth; Renate Looser; Michel Kaufmann; Sharon M Blättler; Franck Rencurel; Wendong Huang; David D Moore; Urs A Meyer
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.

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2013: Urs A Meyer; Ulrich M Zanger; Matthias Schwab
Omics and drug response.
Annual review of pharmacology and toxicology 2013;53():475-502.
2008: Adrian Roth; Renate Looser; Michel Kaufmann; Urs A Meyer
Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
Pharmacogenetics and genomics 2008;18(4):325-37.
2008: Adrian Roth; Renate Looser; Michel Kaufmann; Sharon M Blättler; Franck Rencurel; Wendong Huang; David D Moore; Urs A Meyer
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
Molecular pharmacology 2008;73(4):1282-9.
2007: Anne-Kathrin Peyer; Diana Jung; Markus Beer; Carmela Gnerre; Adrian Keogh; Deborah Stroka; Mihaela Zavolan; Urs A Meyer
Regulation of human liver delta-aminolevulinic acid synthase by bile acids.
Hepatology (Baltimore, Md.) 2007;46(6):1960-70.
2007: Mikael Oscarson; Oliver Burk; Stefan Winter; Matthias Schwab; Renzo Wolbold; Jürgen Dippon; Michel Eichelbaum; Urs A Meyer
Effects of rifampicin on global gene expression in human small intestine.
Pharmacogenetics and genomics 2007;17(11):907-18.
2007: Marco Scarsi; Michael Podvinec; Adrian Roth; Hubert Hug; Sander Kersten; Hugo Albrecht; Torsten Schwede; Urs A Meyer; Christoph Rücker
Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach.
Molecular pharmacology 2007;71(2):398-406.
2007: Sharon M Blättler; Franck Rencurel; Michel R Kaufmann; Urs A Meyer
In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):1045-50.
2007: Urs A Meyer
Endo-xenobiotic crosstalk and the regulation of cytochromes P450.
Drug metabolism reviews 2007;39(2-3):639-46.
2006: Franck Rencurel; Marc Foretz; Michel R Kaufmann; Deborah Stroka; Renate Looser; Isabelle Leclerc; Gabriela da Silva Xavier; Guy A Rutter; Benoit Viollet; Urs A Meyer
Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.
Molecular pharmacology 2006;70(6):1925-34.
2006: Mikael Oscarson; Uli Zanger; Oktay F Rifki; Kathrin Klein; Michel Eichelbaum; Urs A Meyer
Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.
Clinical pharmacology and therapeutics 2006;80(5):440-456.
2006: Diana Jung; David J Mangelsdorf; Urs A Meyer
Pregnane X receptor is a target of farnesoid X receptor.
The Journal of biological chemistry 2006;281(28):19081-91.
2006: Michael Podvinec; Urs A Meyer
Prediction of cis-regulatory elements for drug-activated transcription factors in the regulation of drug-metabolising enzymes and drug transporters.
Expert opinion on drug metabolism & toxicology 2006;2(3):367-79.
2005: Ralf P Meyer; Raija L P Lindberg; Francine Hoffmann; Urs A Meyer
Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.
Biological chemistry 2005;386(11):1157-64.
2005: Michael Haberl; Birgit Anwald; Kathrin Klein; Regina Weil; Christine Fuss; Akçahan Gepdiremen; Uli Zanger; Urs A Meyer; Leszek Wojnowski
Three haplotypes associated with CYP2A6 phenotypes in Caucasians.
Pharmacogenetics and genomics 2005;15(9):609-24.
2005: Christoph Handschin; Jiandie Lin; James Rhee; Anne-Kathrin Peyer; Sherry Chin; Pei-Hsuan Wu; Urs A Meyer; Bruce M Spiegelman
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
Cell 2005;122(4):505-15.
2005: Carmela Gnerre; Gertrud U Schuster; Adrian Roth; Christoph Handschin; Lisen Johansson; Renate Looser; Paolo Parini; Michael Podvinec; Kirsten Robertsson; Jan-�ke GUSTAFSSON; Urs A Meyer
LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.
Journal of lipid research 2005;46(8):1633-42.
2005: Christoph Handschin; Carmela Gnerre; David J Fraser; Celia Martinez-Jimenez; Ramiro Jover; Urs A Meyer
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
Archives of biochemistry and biophysics 2005;434(1):75-85.
2005: Christoph Handschin; Urs A Meyer
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.
Archives of biochemistry and biophysics 2005;433(2):387-96.
2004: Carmela Gnerre; Sharon Blättler; Michel R Kaufmann; Renate Looser; Urs A Meyer
Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.
Pharmacogenetics 2004;14(10):635-45.
2004: Urs A Meyer
Pharmacogenetics - five decades of therapeutic lessons from genetic diversity.
Nature reviews. Genetics 2004;5(9):669-76.
2004: Michael Podvinec; Christoph Handschin; Renate Looser; Urs A Meyer
Identification of the xenosensors regulating human 5-aminolevulinate synthase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9127-32.
2003: Christoph Handschin; Urs A Meyer
Induction of drug metabolism: the role of nuclear receptors.
Pharmacological reviews 2003;55(4):649-73.
2003: David J Fraser; Adrian Zumsteg; Urs A Meyer
Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene.
The Journal of biological chemistry 2003;278(41):39392-401.
2003: Christoph Handschin; Michael Podvinec; Urs A Meyer
In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism.
Drug news & perspectives 2003;16(7):423-34.
2003: Sabyasachi Sanyal; Christoph Handschin; Michael Podvinec; Kwang-Hoon Song; Han-Jong Kim; Joon-Young Kim; Young-Woo Seo; Sung-A Kim; Hyuk Bang Kwon; Keesook Lee; Won-Sun Kim; Urs A Meyer; Hueng-Sik Choi
Molecular cloning and characterization of chicken orphan nuclear receptor cTR2.
General and comparative endocrinology 2003;132(3):474-84.
2002: Urs A Meyer; Josef Gut
Genomics and the prediction of xenobiotic toxicity.
Toxicology 2002;181-182():463-6.
2002: Ralf P Meyer; Michael Podvinec; Urs A Meyer
Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme.
Molecular pharmacology 2002;62(5):1061-7.
2002: David J Fraser; Michael Podvinec; Michel R Kaufmann; Urs A Meyer
Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).
The Journal of biological chemistry 2002;277(38):34717-26.
2002: Paul L M van Giersbergen; Carmela Gnerre; Alexander Treiber; Jasper Dingemanse; Urs A Meyer
Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor.
European journal of pharmacology 2002;450(2):115-21.
2002: Christoph Handschin; Michael Podvinec; Remo Amherd; Renate Looser; Jean-Claude Ourlin; Urs A Meyer
Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.
The Journal of biological chemistry 2002;277(33):29561-7.
2002: Diana Jung; Michael Podvinec; Urs A Meyer; David J Mangelsdorf; Michael Fried; Peter J Meier Abt; Gerd A Kullak-Ublick
Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
Gastroenterology 2002;122(7):1954-66.
2002: Michael Podvinec; Michel R Kaufmann; Christoph Handschin; Urs A Meyer
NUBIScan, an in silico approach for prediction of nuclear receptor response elements.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1269-79.
2002: Manuel Baader; Carmela Gnerre; John J Stegeman; Urs A Meyer
Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit.
The Journal of biological chemistry 2002;277(18):15647-53.
2002: Jean-Claude Ourlin; Christoph Handschin; Michel Kaufmann; Urs A Meyer
A Link between cholesterol levels and phenobarbital induction of cytochromes P450.
Biochemical and biophysical research communications 2002;291(2):378-84.
2001: Christoph Handschin; Michael Podvinec; Renate Looser; Remo Amherd; Urs A Meyer
Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor.
Molecular pharmacology 2001;60(4):681-9.
2001: Christoph Handschin; Michael Podvinec; J Stöckli; K Hoffmann; Urs A Meyer
Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
Molecular endocrinology (Baltimore, Md.) 2001;15(9):1571-85.
2001: R Eiselt; Tammy L Domanski; Arne Zibat; R Mueller; E Presecan-Siedel; Elisabeth Hustert; Uli Zanger; J Brockmoller; H P Klenk; Urs A Meyer; Kishore K Khan; You Ai He; James Halpert; Leszek Wojnowski
Identification and functional characterization of eight CYP3A4 protein variants.
Pharmacogenetics 2001;11(5):447-58.
2001: MM Schuurmans; F Hoffmann; RL Lindberg; Urs A Meyer
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Hepatology (Baltimore, Md.) 2001;33(5):1217-22.
2001: K Gellner; R Eiselt; Elisabeth Hustert; H Arnold; Ina Koch; Michael Haberl; CJ Deglmann; Oliver Burk; D Buntefuss; S Escher; Jack alvarez; HG Koebe; Ulrich Brinkmann; H P Klenk; K Kleine; Urs A Meyer; Leszek Wojnowski
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
Pharmacogenetics 2001;11(2):111-21.
2000: Remo Amherd; E Hintermann; Dieter Walz; M Affolter; Urs A Meyer
Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster.
DNA and cell biology 2000;19(11):697-705.
2000: Christoph Handschin; Michael Podvinec; Urs A Meyer
CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10769-74.
2000: Christoph Handschin; Urs A Meyer
A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.
The Journal of biological chemistry 2000;275(18):13362-9.
2000: Jean-Claude Ourlin; M Baader; D Fraser; James Halpert; Urs A Meyer
Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37).
Archives of biochemistry and biophysics 2000;373(2):375-84.
1999: Urs A Meyer; K Hoffmann
Phenobarbital-mediated changes in gene expression in the liver.
Drug metabolism reviews 1999;31(2):365-73.
1999: RL Lindberg; Rudolf Martini; M Baumgartner; Beat Erne; J Borg; Jürgen Zielasek; K Ricker; A Steck; K V Toyka; Urs A Meyer
Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria.
The Journal of clinical investigation 1999;103(8):1127-34.
1998: D Brodbeck; Remo Amherd; Patrick Callaerts; E Hintermann; Urs A Meyer; M Affolter
Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products.
DNA and cell biology 1998;17(7):621-33.
1998: Urs A Meyer; MM Schuurmans; RL Lindberg
Acute porphyrias: pathogenesis of neurological manifestations.
Seminars in liver disease 1998;18(1):43-52.
1997: F W Frueh; Uli Zanger; Urs A Meyer
Extent and character of phenobarbital-mediated changes in gene expression in the liver.
Molecular pharmacology 1997;51(3):363-9.
1997: Urs A Meyer; Uli Zanger
Molecular mechanisms of genetic polymorphisms of drug metabolism.
Annual review of pharmacology and toxicology 1997;37():269-96.
1996: E Hintermann; Nicole C Grieder; R Amherd; D Brodbeck; Urs A Meyer
Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melanogaster expressed in the nervous system and the gut.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12315-20.
1996: R Jover; K Hoffmann; Urs A Meyer
Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis.
Biochemical and biophysical research communications 1996;226(1):152-7.
1996: R Jover; RL Lindberg; Urs A Meyer
Role of heme in cytochrome P450 transcription and function in mice treated with lead acetate.
Molecular pharmacology 1996;50(3):474-81.
1996: Urs A Meyer; R Amrein; L P Balant; L Bertilsson; M Eichelbaum; T W Guentert; S Henauer; P Jackson; G Laux; H Mikkelsen; C Peck; B G Pollock; R Priest; F Sjöqvist; A Delini-Stula
Antidepressants and drug-metabolizing enzymes--expert group report.
Acta psychiatrica Scandinavica 1996;93(2):71-9.
1996: RL Lindberg; C Porcher; B Grandchamp; Birgit Ledermann; K Bürki; Sebastian Brandner; A Aguzzi; Urs A Meyer
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Nature genetics 1996;12(2):195-9.
1995: E Hintermann; Paul Jenö; Urs A Meyer
Isolation and characterization of an arylalkylamine N-acetyltransferase from Drosophila melanogaster.
FEBS letters 1995;375(1-2):148-50.
1995: A C Kempf; Uli Zanger; Urs A Meyer
Truncated human P450 2D6: expression in Escherichia coli, Ni(2+)-chelate affinity purification, and characterization of solubility and aggregation.
Archives of biochemistry and biophysics 1995;321(2):277-88.
1994: Urs A Meyer
Polymorphism of human acetyltransferases.
Environmental health perspectives 1994;102 Suppl 6():213-6.
1994: M R Probst; M Beer; D Beer; Paul Jenö; Urs A Meyer; R Gasser
Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.
The Journal of biological chemistry 1994;269(34):21650-6.
1994: Urs A Meyer
Pharmacogenetics: the slow, the rapid, and the ultrarapid.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):1983-4.
1993: Nathaniel Rothman; R B Hayes; W Bi; Neil Caporaso; F Broly; R L Woosley; Songnian Yin; P Feng; X You; Urs A Meyer
Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males.
Pharmacogenetics 1993;3(5):250-5.
1993: F Broly; Urs A Meyer
Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene.
Pharmacogenetics 1993;3(3):123-30.
1993: R B Hayes; W Bi; Nathaniel Rothman; F Broly; Neil Caporaso; P Feng; X You; Songnian Yin; R L Woosley; Urs A Meyer
N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers.
Carcinogenesis 1993;14(4):675-8.
1993: R S Kerdar; I Fasshauer; M Probst; M Blum; Urs A Meyer; D Wild
32P-postlabelling studies on the DNA adducts of the food mutagens/carcinogens IQ and PhIP--adduct formation in a chemical system, and by rat and human metabolism.
IARC scientific publications 1993;(124):173-9.
1992: M R Probst; M Blum; I Fasshauer; D D'Orazio; Urs A Meyer; D Wild
The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Carcinogenesis 1992;13(10):1713-7.
1992: M H Heim; Urs A Meyer
Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.
Genomics 1992;14(1):49-58.
1992: Urs A Meyer
[Interindividual differences in the reaction to drugs and poisons].
Therapeutische Umschau. Revue thérapeutique 1992;49(2):97-101.
1991: Urs A Meyer
Genotype or phenotype: the definition of a pharmacogenetic polymorphism.
Pharmacogenetics 1991;1(2):66-7.
1991: M H Heim; M Blum; M Beer; Urs A Meyer
Acetylation of serotonin in the rabbit pineal gland: an N-acetyltransferase with properties distinct from NAT1 and NAT2 is responsible.
Journal of neurochemistry 1991;57(4):1095-9.
1991: F Broly; A Gaedigk; M Heim; M Eichelbaum; K Morike; Urs A Meyer
Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.
DNA and cell biology 1991;10(8):545-58.
1991: H Furuya; Urs A Meyer; Harry V Gelboin; Frank J Gonzalez
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.
Molecular pharmacology 1991;40(3):375-82.
1991: Frank J Gonzalez; Urs A Meyer
Molecular genetics of the debrisoquin-sparteine polymorphism.
Clinical pharmacology and therapeutics 1991;50(3):233-8.
1991: M Blum; A Demierre; D M Grant; M Heim; Urs A Meyer
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5237-41.
1991: K Brøsen; T Zeugin; Urs A Meyer
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine.
Clinical pharmacology and therapeutics 1991;49(6):609-17.
1991: M R Probst; Paul Jenö; Urs A Meyer
Purification and characterization of a human liver arylacetamide deacetylase.
Biochemical and biophysical research communications 1991;177(1):453-9.
1991: D M Grant; M Blum; M Beer; Urs A Meyer
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
Molecular pharmacology 1991;39(2):184-91.
1990: N Hanioka; Shioko Kimura; Urs A Meyer; Frank J Gonzalez
The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.
American journal of human genetics 1990;47(6):994-1001.
1990: M Kagimoto; M Heim; K Kagimoto; T Zeugin; Urs A Meyer
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.
The Journal of biological chemistry 1990;265(28):17209-14.
1990: E Matsunaga; T Zeugin; Uli Zanger; T Aoyama; Urs A Meyer; Frank J Gonzalez
Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation.
The Journal of biological chemistry 1990;265(28):17197-201.
1990: M Blum; M Heim; Urs A Meyer
Nucleotide sequence of rabbit NAT2 encoding polymorphic liver arylamine N-acetyltransferase (NAT).
Nucleic acids research 1990;18(17):5295.
1990: M Blum; M Heim; Urs A Meyer
Nucleotide sequence of rabbit NAT1 encoding monomorphic arylamine N-acetyltransferase.
Nucleic acids research 1990;18(17):5287.
1990: M Heim; Urs A Meyer
Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification.
Lancet 1990;336(8714):529-32.
1990: T B Zeugin; K Brosen; Urs A Meyer
Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method.
Analytical biochemistry 1990;189(1):99-102.
1990: U Marti; Hans-Peter Hauri; Urs A Meyer
Induction of cytochrome P450 by phenobarbital in rat liver visualized by monoclonal antibody immunoelectron microscopy in situ.
European journal of cell biology 1990;52(2):193-200.
1990: M Blum; D M Grant; W McBride; M Heim; Urs A Meyer
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.
DNA and cell biology 1990;9(3):193-203.
1990: D M Grant; K Mörike; M Eichelbaum; Urs A Meyer
Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.
The Journal of clinical investigation 1990;85(3):968-72.
1990: P Nef; T M Larabee; K Kagimoto; Urs A Meyer
Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation.
The Journal of biological chemistry 1990;265(5):2903-7.
1990: Mary Relling; T Aoyama; F J Gonzalez; Urs A Meyer
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.
The Journal of pharmacology and experimental therapeutics 1990;252(1):442-7.
1990: Urs A Meyer
Molecular genetics and the future of pharmacogenetics.
Pharmacology & therapeutics 1990;46(3):349-55.
1990: Urs A Meyer; Radek C Skoda; Uli Zanger
The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms.
Pharmacology & therapeutics 1990;46(2):297-308.
1990: Urs A Meyer; Uli Zanger; Radek C Skoda; D Grant; M Blum
Genetic polymorphisms of drug metabolism.
Progress in liver diseases 1990;9():307-23.
1990: Urs A Meyer
Genetic polymorphisms of drug metabolism.
Fundamental & clinical pharmacology 1990;4(6):595-615.
1989: M Blum; D M Grant; A Demierre; Urs A Meyer
N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9554-7.
1989: Shioko Kimura; M Umeno; Radek C Skoda; Urs A Meyer; Frank J Gonzalez
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
American journal of human genetics 1989;45(6):889-904.
1989: M J Bargetzi; T Aoyama; F J Gonzalez; Urs A Meyer
Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.
Clinical pharmacology and therapeutics 1989;46(5):521-7.
1989: E Matsunaga; Uli Zanger; James P Hardwick; Harry V Gelboin; Urs A Meyer; Frank J Gonzalez
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.
Biochemistry 1989;28(18):7349-55.
1989: S Yamano; P T Nhamburo; T Aoyama; Urs A Meyer; T Inaba; W Kalow; Harry V Gelboin; O W McBride; Frank J Gonzalez
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
Biochemistry 1989;28(18):7340-8.
1989: T Kronbach; D Mathys; M Umeno; F J Gonzalez; Urs A Meyer
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.
Molecular pharmacology 1989;36(1):89-96.
1989: T Aoyama; S Yamano; D J Waxman; D P Lapenson; Urs A Meyer; V Fischer; R Tyndale; T Inaba; W Kalow; Harry V Gelboin
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
The Journal of biological chemistry 1989;264(18):10388-95.
1989: D M Grant; M Blum; A Demierre; Urs A Meyer
Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation.
Nucleic acids research 1989;17(10):3978.
1989: M Blum; D M Grant; A Demierre; Urs A Meyer
Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver.
Nucleic acids research 1989;17(9):3589.
1989: D M Grant; F Lottspeich; Urs A Meyer
Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver.
FEBS letters 1989;244(1):203-7.
1989: Mary Relling; William Evans; R Fonné-Pfister; Urs A Meyer
Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes.
Cancer research 1989;49(1):68-71.
1989: Urs A Meyer; Uli Zanger; Radek C Skoda; D M Grant
Genetic polymorphisms of drug-metabolizing enzymes: molecular mechanisms.
Psychopharmacology series 1989;7():141-7.
1988: Uli Zanger; Hans-Peter Hauri; J Loeper; J C Homberg; Urs A Meyer
Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8256-60.
1988: R Fonne-Pfister; Urs A Meyer
Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism.
Biochemical pharmacology 1988;37(20):3829-35.
1988: Uli Zanger; FRancis VILBOIS; James P Hardwick; Urs A Meyer
Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man.
Biochemistry 1988;27(15):5447-54.
1988: Radek C Skoda; F J Gonzalez; A Demierre; Urs A Meyer
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5240-3.
1988: T Kronbach; V Fischer; Urs A Meyer
Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.
Clinical pharmacology and therapeutics 1988;43(6):630-5.
1988: Frank J Gonzalez; B J Schmid; M Umeno; O W Mcbride; James P Hardwick; Urs A Meyer; Harry V Gelboin; Jeffrey Idle
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
DNA (Mary Ann Liebert, Inc.) 1988;7(2):79-86.
1988: Frank J Gonzalez; Radek C Skoda; Shioko Kimura; M Umeno; Uli Zanger; Daniel W Nebert; Harry V Gelboin; James P Hardwick; Urs A Meyer
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
Nature 1988;331(6155):442-6.
1988: Frank J Gonzalez; FRancis VILBOIS; James P Hardwick; O W McBride; Daniel W Nebert; Harry V Gelboin; Urs A Meyer
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
Genomics 1988;2(2):174-9.
1988: Radek C Skoda; A Demierre; O W McBride; F J Gonzalez; Urs A Meyer
Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.
The Journal of biological chemistry 1988;263(3):1549-54.
1987: U T Meier; Urs A Meyer
Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency.
Biochemistry 1987;26(25):8466-74.
1987: P Dayer; T Kronbach; M Eichelbaum; Urs A Meyer
Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency.
Biochemical pharmacology 1987;36(23):4145-52.
1987: R Fonne-Pfister; M J Bargetzi; Urs A Meyer
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
Biochemical and biophysical research communications 1987;148(3):1144-50.
1987: T Kronbach; D Mathys; J Gut; T Catin; Urs A Meyer
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.
Analytical biochemistry 1987;162(1):24-32.
1986: J Gut; U T Meier; T Catin; Urs A Meyer
Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation.
Biochimica et biophysica acta 1986;884(3):435-47.
1986: J Gut; T Catin; P Dayer; T Kronbach; U Zanger; Urs A Meyer
Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.
The Journal of biological chemistry 1986;261(25):11734-43.
1986: Urs A Meyer; J Gut; T Kronbach; C Skoda; U T Meier; T Catin; P Dayer
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
Xenobiotica; the fate of foreign compounds in biological systems 1986;16(5):449-64.
1985: U T Meier; T Kronbach; Urs A Meyer
Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography.
Analytical biochemistry 1985;151(2):286-91.
1985: U T Meier; P Dayer; P J Malè; T Kronbach; Urs A Meyer
Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo.
Clinical pharmacology and therapeutics 1985;38(5):488-94.
1984: P Dayer; R Gasser; J Gut; T Kronbach; G M Robertz; M Eichelbaum; Urs A Meyer
Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.
Biochemical and biophysical research communications 1984;125(1):374-80.
1984: J Gut; R Gasser; P Dayer; T Kronbach; T Catin; Urs A Meyer
Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation.
FEBS letters 1984;173(2):287-90.