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David Meyre

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Aurora Mejía-Benítez; David Meyre; Jesús Peralta-Romero; Elva Pérez-Luque; Loic Yengo; Celia Aradillas; Esperanza Cruz; Miguel Cruz; Samuel Flores-Huerta; philippe froguel; Maria Eugenia Garay; Jaime García-Mena; Miguel Klunder; Juan Manuel Malacara; Amélie Bonnefond
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.
Konstantinos Rouskas; Fanny Stutzmann; Vincent Vatin; Anastasia Kouvatsi; Marion Marchand; David Meyre; Konstantinos Paletas; Dimitrios Papazoglou; philippe froguel
Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population.
Julia S El-Sayed Moustafa; Mario Falchi; philippe froguel; Eleni Hadjigeorgiou; Peter Jacobson; David Meyre; Lars Sjöström; Rob Sladek; Sophie Visvikis-Siest; Andrew Walley; Robin G Walters; Alexessander Couto Alves; Johanna C Andersson-Assarsson; Julian E Asher; Alexandra I F Blakemore; Leonardo Bottolo; Jessica L Buxton; Lena M S Carlsson; Adam J de Smith; Christian Dina; Hariklia Eleftherohorinou; Lachlan J M Coin
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.

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All Publications

2013: Aurora Mejía-Benítez; David Meyre; Jesús Peralta-Romero; Elva Pérez-Luque; Loic Yengo; Celia Aradillas; Esperanza Cruz; Miguel Cruz; Samuel Flores-Huerta; philippe froguel; Maria Eugenia Garay; Jaime García-Mena; Miguel Klunder; Juan Manuel Malacara; Amélie Bonnefond
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.
BMC medical genetics 2013;14():21.
2012: Konstantinos Rouskas; Fanny Stutzmann; Vincent Vatin; Anastasia Kouvatsi; Marion Marchand; David Meyre; Konstantinos Paletas; Dimitrios Papazoglou; philippe froguel
Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population.
Obesity (Silver Spring, Md.) 2012;20(11):2278-82.
2012: Julia S El-Sayed Moustafa; Mario Falchi; philippe froguel; Eleni Hadjigeorgiou; Peter Jacobson; David Meyre; Lars Sjöström; Rob Sladek; Sophie Visvikis-Siest; Andrew Walley; Robin G Walters; Alexessander Couto Alves; Johanna C Andersson-Assarsson; Julian E Asher; Alexandra I F Blakemore; Leonardo Bottolo; Jessica L Buxton; Lena M S Carlsson; Adam J de Smith; Christian Dina; Hariklia Eleftherohorinou; Lachlan J M Coin
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.
Human molecular genetics 2012;21(16):3727-38.
2012: John W M Creemers; Paul Elliott; philippe froguel; Fritz Horber; Marjo-Riitta Jarvelin; Sandra M P Meulemans; Beverley Balkau; Sigri Beckers; Hélène Choquet; François Pattou; Marie Pigeyre; Pieter Stijnen; Maithé Tauber; Manuel E Than; Luc Van Gaal; Wim Van Hul; Vincent Vatin; Loïc Yengo; David Meyre
Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
Diabetes 2012;61(2):383-90.
2012: Konstantinos Rouskas; Apostolos Tsapas; Vincent Vatin; Jérôme Delplanque; Emmanuelle Durand; Anastasia Kouvatsi; Yann Labrune; Stéphane Lobbens; David Meyre; Konstantinos Paletas; Dimitrios Papazoglou; philippe froguel
Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.
Obesity (Silver Spring, Md.) 2012;20(2):389-95.
2012: Anita Morandi; Anneli Pouta; Sheryl L Rifas-Shiman; Aimo Ruokonen; Vincent Vatin; Shikta Das; Paul Elliott; Stefan Gaget; Matthew W Gillman; Anna-Liisa Hartikainen; Marjo-Riitta Järvelin; Marika Kaakinen; Anokhi Ali Khan; Ken Kleinman; Jaana Laitinen; Stéphane Lobbens; Claudio Maffeis; David Meyre; philippe froguel
Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts.
PloS one 2012;7(11):e49919.
2012: philippe froguel; Rosa-Maria Guéant-Rodriguez; Bernard Herbeth; Peter Jacobson; Marjo-Riitta Jarvelin; Yann Labrune; Michel R Langlois; Cécile Lecoeur; Claudio Maffeis; David Meyre; Anita Morandi; Ndeye Coumba Ndiaye; Aimo Ruokonen; Gérard Siest; Lars Sjöström; Maria G Stathopoulou; Amélie Bonnefond; Leonardo Bottolo; Nabila Bouatia-Naji; Lena M S Carlsson; Aurélie Dechaume; George V Dedoussis; Joris R Delanghe; Said El Shamieh; Paul Elliott; Mario Falchi; Andrew Walley; Sophie Visvikis-Siest
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.
PloS one 2012;7(3):e32327.
2011: Hélène Choquet; David Meyre
Genetics of Obesity: What have we Learned?
Current genomics 2011;12(3):169-79.
2011: Hélène Choquet; David Meyre
Molecular basis of obesity: current status and future prospects.
Current genomics 2011;12(3):154-68.
2011: Jessica Louise Buxton; Robin G Walters; Sophie Visvikis-Siest; David Meyre; philippe froguel; Alexandra I F Blakemore
Childhood obesity is associated with shorter leukocyte telomere length.
The Journal of clinical endocrinology and metabolism 2011;96(5):1500-5.
2011: Hélène Choquet; Yann Labrune; Franck De Graeve; Anke Hinney; Johannes Hebebrand; André Scherag; Cécile Lecoeur; Maithé Tauber; Beverley Balkau; Paul Elliot; Marjo-Riitta Jarvelin; Andrew J Walley; Philippe Besnard; philippe froguel; David Meyre
Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects.
Obesity (Silver Spring, Md.) 2011;19(4):833-9.
2010: R Bouhaha; H Choquet; David Meyre; H Abid Kamoun; Hajer Ennafaa; T Baroudi; R Sassi; Martine Vaxillaire; Amel Elgaaied; philippe froguel; S Cauchi
TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia.
Pathologie-biologie 2010;58(6):426-9.
2010: Lijun Ma; Robert L Hanson; Michael T Traurig; Yunhua L Muller; Bakhshish P Kaur; Jessica M Perez; David Meyre; Mao Fu; Antje Körner; Paul W Franks; Wieland Kiess; Sayuko Kobes; William C Knowler; Peter Kovacs; philippe froguel; Alan R Shuldiner; Clifton Bogardus; Leslie J Baier
Evaluation of A2BP1 as an obesity gene.
Diabetes 2010;59(11):2837-45.
2010: Nabila Bouatia-Naji; Amélie Bonnefond; Devin A Baerenwald; Marion Marchand; Marco Bugliani; Piero Marchetti; François Pattou; Richard L Printz; Brian P Flemming; Obi C Umunakwe; Nicholas L Conley; Martine Vaxillaire; Olivier Lantieri; Beverley Balkau; Michel Marre; Claire Lévy-Marchal; Paul Elliott; Marjo-Riitta Jarvelin; David Meyre; Christian Dina; James K Oeser; philippe froguel; Richard M O'Brien
Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
Diabetes 2010;59(10):2662-71.
2010: Maya Ghoussaini; Fanny Stutzmann; Cyril Couturier; Vincent Vatin; Emmanuelle Durand; Cécile Lecoeur; Franck Degraeve; Barbara Heude; Maithé Tauber; Serge Hercberg; Claire Levy-Marchal; Patrick Tounian; Jacques Weill; Michael Traurig; Clifton Bogardus; Leslie J Baier; Jacques L Michaud; philippe froguel; David Meyre
Analysis of the SIM1 contribution to polygenic obesity in the French population.
Obesity (Silver Spring, Md.) 2010;18(8):1670-5.
2010: Anita Morandi; Claudio Maffeis; Stéphane Lobbens; Nabila Bouatia-Naji; Barbara Heude; Leonardo Pinelli; David Meyre; philippe froguel
Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia.
Obesity (Silver Spring, Md.) 2010;18(7):1469-73.
2010: Niels Vrang; David Meyre; Phillippe Froguel; Jacob Jelsing; Mads Tang-Christensen; Vincent Vatin; Jens D Mikkelsen; Kenneth Thirstrup; Leif K Larsen; Karina B Cullberg; Jan Fahrenkrug; Peter Jacobson; Lars Sjöström; Lena M S Carlsson; Yongjun Liu; Xiaogang Liu; Hong-Wen Deng; Philip J Larsen
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.
Obesity (Silver Spring, Md.) 2010;18(7):1289-96.
2010: Ehm A Andersson; Birgitte Holst; Thomas Sparsø; Niels Grarup; Karina Banasik; Johan Holmkvist; Torben Jørgensen; Knut Borch-Johnsen; Kristoffer Lihme Egerod; Torsten Lauritzen; Thorkild I A Sørensen; Amélie Bonnefond; David Meyre; philippe froguel; Thue W Schwartz; Oluf Pedersen; Torben Hansen
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.
Diabetes 2010;59(6):1539-48.
2010: Francis Vasseur; Thomas Caeyseele; Mouna Barat-Houari; Stéphane Lobbens; Aline Meirhaeghe; David Meyre; philippe froguel; Philippe Amouyel; Nicole Helbecque
Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population.
Journal of human genetics 2010;55(4):227-31.
2010: Rym Bouhaha; Thouraya Baroudi; Hajer Ennafaa; Emanuel Vaillant; Hafawa Abid; Rim Sassi; Vincent Vatin; philippe froguel; Amel Benammar-el Gaaied; David Meyre; Martine Vaxillaire
Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.
Clinical biochemistry 2010;43(6):549-52.
2010: Hélène Choquet; David Meyre
Genomic insights into early-onset obesity.
Genome medicine 2010;2(6):36.
2010: David Meyre; Karine Proulx; Hiroko Kawagoe-Takaki; Vincent Vatin; Ruth Gutiérrez-Aguilar; Debbie Lyon; Marcella Ma; Hélène Choquet; Fritz F Horber; Wim Van Hul; Luc Van Gaal; Beverley Balkau; Sophie Visvikis-Siest; François Pattou; I Sadaf Farooqi; Vladimir Saudek; Stephen O'Rahilly; philippe froguel; Barbara Sedgwick; Giles S H Yeo
Prevalence of loss-of-function FTO mutations in lean and obese individuals.
Diabetes 2010;59(1):311-8.
2009: Amélie Bonnefond; Martine Vaxillaire; Yann Labrune; Cécile Lecoeur; Jean-Claude Chèvre; Nabila Bouatia-Naji; Stéphane Cauchi; Beverley Balkau; Michel Marre; Jean Tichet; Jean-Pierre Riveline; Samy HADJADJ; Yves Gallois; Sébastien Czernichow; Serge Hercberg; Marika Kaakinen; Susanne Wiesner; Guillaume Charpentier; Claire Lévy-Marchal; Paul Elliott; Marjo-Riitta Jarvelin; Fritz Horber; Christian Dina; Oluf Pedersen; Robert Sladek; David Meyre; philippe froguel
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
Diabetes 2009;58(11):2687-97.
2009: Alexandra I F Blakemore; David Meyre; Jerome Delplanque; Vincent Vatin; Cecile Lecoeur; Michel Marre; Jean Tichet; Beverley Balkau; philippe froguel; Andrew J Walley
A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity.
Obesity (Silver Spring, Md.) 2009;17(8):1549-53.
2009: Sarah Boissel; Orit Reish; Karine Proulx; Hiroko Kawagoe-Takaki; Barbara Sedgwick; Giles S H Yeo; David Meyre; Christelle Golzio; Florence Molinari; Noman Kadhom; Heather C Etchevers; Vladimir Saudek; I Sadaf Farooqi; philippe froguel; Tomas Lindahl; Stephen O'Rahilly; Arnold Munnich; Laurence Colleaux
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.
American journal of human genetics 2009;85(1):106-11.
2009: Michael Traurig; Janel Mack; Robert L Hanson; Maya Ghoussaini; David Meyre; William C Knowler; Sayuko Kobes; philippe froguel; Clifton Bogardus; Leslie J Baier
Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
Diabetes 2009;58(7):1682-9.
2009: Hélène Choquet; Christine Cavalcanti-Proença; Cécile Lecoeur; Christian Dina; Stéphane Cauchi; Martine Vaxillaire; Samy HADJADJ; Fritz F Horber; Natascha Potoczna; Guillaume Charpentier; Juan Ruiz; Serge Hercberg; Suliya Maimaitiming; Ronan Roussel; Michael Boenhnke; Anne U Jackson; Wolfgang Patsch; Franz Krempler; Benjamin F Voight; David Altshuler; Leif Groop; Gudmar Thorleifsson; Valgerdur Steinthorsdottir; Kari Stefansson; Beverley Balkau; philippe froguel; David Meyre
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.
Human molecular genetics 2009;18(13):2495-501.
2009: Stéphane Cauchi; Fanny Stutzmann; Christine Cavalcanti-Proença; Emmanuelle Durand; Anneli Pouta; Anna-Liisa Hartikainen; Michel Marre; Sylviane Vol; Tuija Tammelin; Jaana Laitinen; Arturo Gonzalez-Izquierdo; Alexandra I F Blakemore; Paul Elliott; David Meyre; Beverley Balkau; Marjo-Riitta Järvelin; philippe froguel
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):537-46.
2009: Maria Gueorguiev; Cécile Lecoeur; David Meyre; Michael Benzinou; Charles A Mein; Anke Hinney; Vincent Vatin; Jacques Weill; Barbara Heude; Johannes Hebebrand; Ashley B Grossman; Marta Korbonits; philippe froguel
Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.
Obesity (Silver Spring, Md.) 2009;17(4):745-54.
2009: F Stutzmann; Stéphane Cauchi; Emmanuelle Durand; C Calvacanti-Proença; M Pigeyre; A-L Hartikainen; Ulla Sovio; Jean Tichet; Michel Marre; Jacques Weill; Beverley Balkau; Natascha Potoczna; J Laitinen; Paul Elliott; M-R Järvelin; Fritz F Horber; David Meyre; philippe froguel
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.
International journal of obesity (2005) 2009;33(3):373-8.
2008: Fanny Stutzmann; Karen Tan; Vincent Vatin; Christian Dina; Béatrice Jouret; Jean Tichet; Beverley Balkau; Natascha Potoczna; Fritz Horber; Stephen O'Rahilly; I Sadaf Farooqi; philippe froguel; David Meyre
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.
Diabetes 2008;57(9):2511-8.
2008: Anne-Kathrin Wermter; André Scherag; David Meyre; Kathrin Reichwald; Emmanuelle Durand; Thuy Trang Nguyen; Kerstin Koberwitz; Peter Lichtner; Thomas Meitinger; Helmut Schäfer; Anke Hinney; philippe froguel; Johannes Hebebrand; Günter Brönner
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.
European journal of human genetics : EJHG 2008;16(9):1126-34.
2008: Michael Benzinou; Jean-Claude Chèvre; Kirsten J Ward; Cécile Lecoeur; Christian Dina; Stephane Lobbens; Emmanuelle Durand; Jérôme Delplanque; Fritz F Horber; Barbara Heude; Beverley Balkau; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen; David Meyre; philippe froguel
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
Human molecular genetics 2008;17(13):1916-21.
2008: Yong-Jun Liu; Xiao-Gang Liu; Liang Wang; Christian Dina; Han Yan; Jian-Feng Liu; Shawn Levy; Christopher J Papasian; Betty M Drees; James J Hamilton; David Meyre; Jerome Delplanque; Yu-Fang Pei; Lei Zhang; Robert R Recker; philippe froguel; Hong-Wen Deng
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
Human molecular genetics 2008;17(12):1803-13.
2008: David Meyre; Morgane Farge; Cécile Lecoeur; Christine Proenca; Emmanuelle Durand; Frédéric Allegaert; Jean Tichet; Michel Marre; Beverley Balkau; Jacques Weill; Jérôme Delplanque; philippe froguel
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.
Human molecular genetics 2008;17(12):1798-802.
2008: Nabila Bouatia-Naji; Franck De Graeve; Günter Brönner; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Peter Lichtner; Thuy T Nguyen; Barbara Heude; Jacques Weill; Claire Lévy-Marchal; Johannes Hebebrand; philippe froguel; David Meyre
INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study.
Obesity (Silver Spring, Md.) 2008;16(6):1471-5.
2008: Nabila Bouatia-Naji; Ghislain Rocheleau; Leentje Van Lommel; Katleen Lemaire; Frans Schuit; Christine Cavalcanti-Proença; Marion Marchand; Anna-Liisa Hartikainen; Ulla Sovio; Franck De Graeve; Johan Rung; Martine Vaxillaire; Jean Tichet; Michel Marre; Beverley Balkau; Jacques Weill; Paul Elliott; Marjo-Riitta Jarvelin; David Meyre; Constantin Polychronakos; Christian Dina; Robert Sladek; philippe froguel
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.
Science (New York, N.Y.) 2008;320(5879):1085-8.
2008: Stéphane Cauchi; Christine Proença; Hélène Choquet; Stefan Gaget; Franck De Graeve; Michel Marre; Beverley Balkau; Jean Tichet; David Meyre; Martine Vaxillaire; philippe froguel
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
Journal of molecular medicine (Berlin, Germany) 2008;86(3):341-8.
2008: Stéphane Cauchi; Hélène Choquet; Ruth Gutiérrez-Aguilar; Frédéric Capel; Katrine Grau; Christine Proença; Christian Dina; Alex Duval; Beverley Balkau; Michel Marre; Natascha Potoczna; Dominique Langin; Fritz Horber; Thorkild I A Sørensen; Guillaume Charpentier; David Meyre; philippe froguel
Effects of TCF7L2 polymorphisms on obesity in European populations.
Obesity (Silver Spring, Md.) 2008;16(2):476-82.
2008: Catherine Le Stunff; Agnès Dechartres; Virginie Mariot; Chantal Lotton; Cecelia Trainor; Emanuele Miraglia del Giudice; David Meyre; Ivan Bieche; Ingrid Laurendeau; philippe froguel; Diana Zelenika; Daniele Fallin; Mark Lathrop; Paul-Henri Roméo; Pierre Bougnères
Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.
Diabetes 2008;57(2):494-502.
2008: Emmanuelle Durand; Cécile Lecoeur; Jérôme Delplanque; Michael Benzinou; Franck Degraeve; Philippe Boutin; Michel Marre; Beverley Balkau; Guillaume Charpentier; philippe froguel; David Meyre
Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population.
Obesity facts 2008;1(6):305-9.
2008: Stéphane Cauchi; Kevin T Nead; Hélène Choquet; Fritz Horber; Natascha Potoczna; Beverley Balkau; Michel Marre; Guillaume Charpentier; philippe froguel; David Meyre
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
BMC medical genetics 2008;9():45.
2008: Stéphane Cauchi; David Meyre; Emmanuelle Durand; Christine Proença; Michel Marre; Samy HADJADJ; Hélène Choquet; Franck De Graeve; Stefan Gaget; Frederic Allegaert; Jérôme Delplanque; Marshall Alan Permutt; Jon Wasson; Ilana Blech; Guillaume Charpentier; Beverley Balkau; Anne-Claire Vergnaud; Sebastien czernichow; Wolfgang Patsch; Mohamed Chikri; Benjamin Glaser; Robert Sladek; philippe froguel
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
PloS one 2008;3(5):e2031.
2008: Martine Vaxillaire; Jacques Veslot; Christian Dina; Christine Proença; Stéphane Cauchi; Guillaume Charpentier; Jean Tichet; Frédéric Fumeron; Michel Marre; David Meyre; Beverley Balkau; philippe froguel
Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.
Diabetes 2008;57(1):244-54.
2007: Maya Ghoussaini; Vincent Vatin; Cécile Lecoeur; Victor Abkevich; Adib Younus; Chantal Samson; Christophe Wachter; Barbara Heude; Maïthé Tauber; Patrick Tounian; Serge Hercberg; Jacques Weill; Claire Levy-Marchal; Catherine Le Stunff; Pierre Bougnères; philippe froguel; David Meyre
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
The Journal of clinical endocrinology and metabolism 2007;92(11):4403-9.
2007: David Meyre; Nabila Bouatia-Naji; Vincent Vatin; Jacques Veslot; Chantal Samson; Jean Tichet; Michel Marre; Beverley Balkau; philippe froguel
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.
Diabetologia 2007;50(10):2090-6.
2007: Jukka T Salonen; Pekka Uimari; Juha-Matti Aalto; Mia Pirskanen; Jari Kaikkonen; Boryana Todorova; Jelena Hyppönen; Veli-Pekka Korhonen; Janne Asikainen; Christopher Devine; Tomi-Pekka Tuomainen; Jan Luedemann; Matthias Nauck; Wolfgang Kerner; Richard H Stephens; John P New; W E R Ollier; J Martin Gibson; Antony Payton; Michael A Horan; Neil Pendleton; Walt Mahoney; David Meyre; Jerôme Delplanque; philippe froguel; Oren Luzzatto; Benjamin Yakir; Saurav Guha
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
American journal of human genetics 2007;81(2):338-45.
2007: Fanny Stutzmann; Vincent Vatin; Stéphane Cauchi; Anita Morandi; Béatrice Jouret; Olfert Landt; Patrick Tounian; Claire Levy-Marchal; Raffaella Buzzetti; Leonardo Pinelli; Beverley Balkau; Fritz F Horber; Pierre Bougnères; philippe froguel; David Meyre
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.
Human molecular genetics 2007;16(15):1837-44.
2007: Stéphane Cauchi; Younes El Achhab; Hélène Choquet; Christian Dina; Franz Krempler; Raimund Weitgasser; Chakib Nejjari; Wolfgang Patsch; Mohamed Chikri; David Meyre; philippe froguel
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.
Journal of molecular medicine (Berlin, Germany) 2007;85(7):777-82.
2007: Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena Carlsson; Wieland Kiess; Vincent Vatin; Cécile Lecoeur; Jérôme Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz F Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; philippe froguel
Variation in FTO contributes to childhood obesity and severe adult obesity.
Nature genetics 2007;39(6):724-6.
2007: Afshan Siddiq; Maria Gueorguiev; Chantal Samson; S Hercberg; Barbara Heude; Claire Levy-Marchal; Béatrice Jouret; J Weill; David Meyre; Andrew J Walley; philippe froguel
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.
Diabetologia 2007;50(3):574-84.
2007: Christopher G Bell; David Meyre; Enrico Petretto; Claire Levy-Marchal; Serge Hercberg; Marie-Aline Charles; Cliona Boyle; Jacques Weill; Maïte Tauber; Charles A Mein; Timothy J Aitman; philippe froguel; Andrew J Walley
No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases.
European journal of human genetics : EJHG 2007;15(3):320-7.
2007: Robert Sladek; Ghislain Rocheleau; Johan Rung; Christian Dina; Lishuang Shen; david serre; Philippe Boutin; Daniel Vincent; Alexandre Belisle; Samy HADJADJ; Beverley Balkau; Barbara Heude; Guillaume Charpentier; Thomas J Hudson; Alexandre Montpetit; Alexey V Pshezhetsky; Marc Prentki; Barry Posner; David J Balding; David Meyre; Constantin Polychronakos; philippe froguel
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Nature 2007;445(7130):881-5.
2007: Christian Dina; David Meyre; Chantal Samson; Jean Tichet; Michel Marre; Béatrice Jouret; Marie-Aline Charles; Beverley Balkau; philippe froguel
Comment on "A common genetic variant is associated with adult and childhood obesity".
Science (New York, N.Y.) 2007;315(5809):187; author reply 187.
2007: Nabila Bouatia-Naji; Vincent Vatin; Cécile Lecoeur; Barbara Heude; Christine Proença; Jacques Veslot; Béatrice Jouret; Jean Tichet; Guillaume Charpentier; Michel Marre; Beverley Balkau; philippe froguel; David Meyre
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.
BMC medical genetics 2007;8():44.
2007: Stéphane Cauchi; David Meyre; Hélène Choquet; Samia Deghmoun; Emmanuelle Durand; Stefan Gaget; Cécile Lecoeur; philippe froguel; Claire Levy-Marchal
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.
BMC medical genetics 2007;8():37.
2006: Stéphane Cauchi; David Meyre; Hélène Choquet; Christian Dina; Catherine Born; Michel Marre; Beverley Balkau; philippe froguel
TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.
Diabetes 2006;55(11):3189-92.
2006: Stéphane Cauchi; David Meyre; Christian Dina; Hélène Choquet; Chantal Samson; Sophie Gallina; Beverley Balkau; Guillaume Charpentier; François Pattou; Volodymyr Stetsyuk; Raphael Scharfmann; Bart Staels; Gema Frühbeck; philippe froguel
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Diabetes 2006;55(10):2903-8.
2006: Michael Benzinou; Andrew J Walley; Stéphane Lobbens; Marie-Aline Charles; Béatrice Jouret; Frédéric Fumeron; Beverley Balkau; David Meyre; philippe froguel
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians.
Diabetes 2006;55(10):2876-82.
2006: Adrien Kettaneh; Barbara Heude; Jean-Michel Oppert; Philipp Scherer; David Meyre; Jean-Michel Borys; Pierre Ducimetiere; Marie-Aline Charles
Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children: the FLVS II study.
Metabolism: clinical and experimental 2006;55(9):1171-6.
2006: Thuy-Ai Vu-Hong; Emmanuelle Durand; Samia Deghmoun; Philippe Boutin; David Meyre; Didier Chevenne; Paul Czernichow; philippe froguel; Claire Levy-Marchal
The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.
The Journal of clinical endocrinology and metabolism 2006;91(6):2437-40.
2006: David Meyre; philippe froguel
[ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes].
Médecine sciences : M/S 2006;22(3):308-12.
2006: Yung Seng Lee; Benjamin G Challis; Darren A Thompson; Giles S H Yeo; Julia M Keogh; Michael E Madonna; Vicki Wraight; Matthew Sims; Vincent Vatin; David Meyre; Julian Shield; Christine Burren; Zala Ibrahim; Tim Cheetham; Peter Swift; Anthea Blackwood; Chiao-Chien Connie Hung; Nicholas J Wareham; philippe froguel; Glenn L Millhauser; Stephen O'Rahilly; I Sadaf Farooqi
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.
Cell metabolism 2006;3(2):135-40.
2006: Nabila Bouatia-Naji; David Meyre; Stéphane Lobbens; Karin Séron; Frédéric Fumeron; Beverley Balkau; Barbara Heude; Béatrice Jouret; Philipp E Scherer; Christian Dina; Jacques Weill; philippe froguel
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity.
Diabetes 2006;55(2):545-50.
2006: Francis Vasseur; David Meyre; philippe froguel
Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies.
Expert reviews in molecular medicine 2006;8(27):1-12.
2005: Christopher G Bell; David Meyre; Chantal Samson; Cliona Boyle; Cécile Lecoeur; Maïte Tauber; Béatrice Jouret; Delphine Jaquet; Claire Levy-Marchal; Marie-Aline Charles; Jacques Weill; Fernando Gibson; Charles A Mein; philippe froguel; Andrew J Walley
Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.
Diabetes 2005;54(10):3049-55.
2005: David Meyre; Nabila Bouatia-Naji; Agnès Tounian; Chantal Samson; Cécile Lecoeur; Vincent Vatin; Maya Ghoussaini; Christophe Wachter; Serge Hercberg; Guillaume Charpentier; Wolfgang Patsch; François Pattou; Marie-Aline Charles; Patrick Tounian; Karine Clément; Béatrice Jouret; Jacques Weill; Betty A Maddux; Ira D Goldfine; Andrew J Walley; Philippe Boutin; Christian Dina; philippe froguel
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Nature genetics 2005;37(8):863-7.
2005: David Meyre; Philippe Boutin; Agnès Tounian; Marianne Deweirder; Mounir Aout; Béatrice Jouret; Barbara Heude; Jacques Weill; Maïthé Tauber; Patrick Tounian; philippe froguel
Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?
The Journal of clinical endocrinology and metabolism 2005;90(4):2384-90.
2005: Maya Ghoussaini; David Meyre; Stéphane Lobbens; Guillaume Charpentier; Karine Clément; Marie-Aline Charles; Maïthé Tauber; Jacques Weill; philippe froguel
Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population.
BMC medical genetics 2005;6():11.
2004: Emmanuelle Durand; Philippe Boutin; David Meyre; Marie-Aline Charles; Karine Clement; Christian Dina; philippe froguel
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians.
Diabetes 2004;53(9):2483-6.
2004: Delphine Eberlé; Karine Clément; David Meyre; Mourad Sahbatou; Martine Vaxillaire; Annie Le Gall; Pascal Ferré; Arnaud Basdevant; philippe froguel; Fabienne Foufelle
SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.
Diabetes 2004;53(8):2153-7.
2004: Christopher G Bell; Michael Benzinou; Afshan Siddiq; Cécile Lecoeur; Christian Dina; Arnaud Lemainque; Karine Clément; Arnaud Basdevant; Bernard Guy-Grand; Charles A Mein; David Meyre; philippe froguel
Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q.
Diabetes 2004;53(7):1857-65.
2004: David Meyre; Cécile Lecoeur; Jérôme Delplanque; Stephan Francke; Vincent Vatin; Emmanuelle Durand; Jacques Weill; Christian Dina; philippe froguel
A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2.
Diabetes 2004;53(3):803-11.