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Oded Meyuhas

Research Profile

Physiology

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Mouse
Rats

Chemicals & Drugs

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Phosphorylation

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Abed Khalaileh; Areej Khatib; Norma Kidess-Bassir; Anirban Maitra; Oded Meyuhas; Avital Swisa; Roy Apel; Yuval Dor; Avigail Dreazen; Gideon Zamir
Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer.
Andrew C Hsieh; Maria Costa; Ornella Zollo; Cole Davis; Morris E Feldman; Joseph R Testa; Oded Meyuhas; Kevan M Shokat; Davide Ruggero
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
Zvi Granot; Avital Swisa; Judith Magenheim; Miri Stolovich-Rain; Wakako Fujimoto; Elisabetta Manduchi; Takashi Miki; Jochen K Lennerz; Christian J Stoeckert; Oded Meyuhas; Susumu Seino; M Alan Permutt; Helen Piwnica-Worms; Nabeel Bardeesy; Yuval Dor
LKB1 regulates pancreatic beta cell size, polarity, and function.

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All Publications

2013: Abed Khalaileh; Areej Khatib; Norma Kidess-Bassir; Anirban Maitra; Oded Meyuhas; Avital Swisa; Roy Apel; Yuval Dor; Avigail Dreazen; Gideon Zamir
Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer.
Cancer research 2013;73(6):1811-20.
2010: Andrew C Hsieh; Maria Costa; Ornella Zollo; Cole Davis; Morris E Feldman; Joseph R Testa; Oded Meyuhas; Kevan M Shokat; Davide Ruggero
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
Cancer cell 2010;17(3):249-61.
2009: Zvi Granot; Avital Swisa; Judith Magenheim; Miri Stolovich-Rain; Wakako Fujimoto; Elisabetta Manduchi; Takashi Miki; Jochen K Lennerz; Christian J Stoeckert; Oded Meyuhas; Susumu Seino; M Alan Permutt; Helen Piwnica-Worms; Nabeel Bardeesy; Yuval Dor
LKB1 regulates pancreatic beta cell size, polarity, and function.
Cell metabolism 2009;10(4):296-308.
2009: Ilona Patursky-Polischuk; Miri Stolovich-Rain; Mirit Hausner-Hanochi; Judith Kasir; Nadine Cybulski; Joseph Avruch; Markus A Rüegg; Michael N Hall; Oded Meyuhas
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Molecular and cellular biology 2009;29(3):640-9.
2009: Oded Meyuhas; Avigail Dreazen
Ribosomal protein S6 kinase from TOP mRNAs to cell size.
Progress in molecular biology and translational science 2009;90():109-53.
2009: Igor Ruvinsky; Maximiliano Katz; Avigail Dreazen; Yuval Gielchinsky; Ann Saada (Reisch); Nanette Freedman; Eyal Mishani; Gabriel Zimmerman; Judith Kasir; Oded Meyuhas
Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit.
PloS one 2009;4(5):e5618.
2008: Andreas Markert; Michael Grimm; Javier Martinez; Julia Wiesner; Andreas Meyerhans; Oded Meyuhas; Albert Sickmann; Utz Fischer
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.
EMBO reports 2008;9(6):569-75.
2008: Oded Meyuhas
Physiological roles of ribosomal protein S6: one of its kind.
International review of cell and molecular biology 2008;268():1-37.
2006: Igor Ruvinsky; Oded Meyuhas
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.
Trends in biochemical sciences 2006;31(6):342-8.
2005: Igor Ruvinsky; Nitzan Sharon; Tal Lerer; Hannah Cohen; Miri Stolovich-Rain; Tomer Nir; Yuval Dor; Philip Zisman; Oded Meyuhas
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.
Genes & development 2005;19(18):2199-211.
2005: Rotem Karni; Yael Gus; Yuval Dor; Oded Meyuhas; Alexander Levitzki
Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation.
Molecular and cellular biology 2005;25(12):5031-9.
2005: Miri Stolovich; Tal Lerer; Yoav Bolkier; Hannah Cohen; Oded Meyuhas
Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner.
The Journal of biological chemistry 2005;280(7):5336-42.
2002: Miri Stolovich; Hua Tang; Eran Hornstein; Galit Levy; Ruth Cohen; Sun Sik Bae; Morris J Birnbaum; Oded Meyuhas
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation.
Molecular and cellular biology 2002;22(23):8101-13.
2002: Rotem Karni; Yuval Dor; Eli Keshet; Oded Meyuhas; Alexander Levitzki
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia.
The Journal of biological chemistry 2002;277(45):42919-25.
2002: Diane Barth-Baus; Carl A Stratton; Lou Parrott; Howard Myerson; Oded Meyuhas; Dennis J Templeton; Gary Landreth; Jack O Hensold
S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells.
Nucleic acids research 2002;30(9):1919-28.
2001: Hua Tang; Eran Hornstein; Miri Stolovich; Galit Levy; Mark Livingstone; Dennis J Templeton; J Avruch; Oded Meyuhas
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.
Molecular and cellular biology 2001;21(24):8671-83.
2001: M Kerner; Oded Meyuhas; Danielle Hirsch-Lerner; Laura J Rosen; Z Min; Yechezkel Barenholz
Interplay in lipoplexes between type of pDNA promoter and lipid composition determines transfection efficiency of human growth hormone in NIH3T3 cells in culture.
Biochimica et biophysica acta 2001;1532(1-2):128-36.
2001: Eran Hornstein; Hua Tang; Oded Meyuhas
Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs.
Cold Spring Harbor symposia on quantitative biology 2001;66():477-84.
2000: Oded Meyuhas
Synthesis of the translational apparatus is regulated at the translational level.
European journal of biochemistry / FEBS 2000;267(21):6321-30.
1999: Eran Hornstein; H Harel; Galit Levy; Oded Meyuhas
Overexpression of poly(A)-binding protein down-regulates the translation or the abundance of its own mRNA.
FEBS letters 1999;457(2):209-13.
1999: Y Biberman; Oded Meyuhas
TOP mRNAs are translationally inhibited by a titratable repressor in both wheat germ extract and reticulocyte lysate.
FEBS letters 1999;456(3):357-60.
1999: Eran Hornstein; Anna Git; I Braunstein; D Avni; Oded Meyuhas
The expression of poly(A)-binding protein gene is translationally regulated in a growth-dependent fashion through a 5'-terminal oligopyrimidine tract motif.
The Journal of biological chemistry 1999;274(3):1708-14.
1998: Z C Zhang; hovav nechushtan; Jasmine Jacob-Hirsch; D Avni; Oded Meyuhas; Ehud Razin
Growth-dependent and PKC-mediated translational regulation of the upstream stimulating factor-2 (USF2) mRNA in hematopoietic cells.
Oncogene 1998;16(6):763-9.
1997: Y Biberman; Oded Meyuhas
Substitution of just five nucleotides at and around the transcription start site of rat beta-actin promoter is sufficient to render the resulting transcript a subject for translational control.
FEBS letters 1997;405(3):333-6.
1997: D Avni; Y Biberman; Oded Meyuhas
The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.
Nucleic acids research 1997;25(5):995-1001.
1996: S Shama; Oded Meyuhas
The translational cis-regulatory element of mammalian ribosomal protein mRNAs is recognized by the plant translational apparatus.
European journal of biochemistry / FEBS 1996;236(2):383-8.
1995: S Shama; D Avni; R M Frederickson; N Sonenberg; Oded Meyuhas
Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.
Gene expression 1995;4(4-5):241-52.
1994: D Avni; S Shama; F Loreni; Oded Meyuhas
Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element.
Molecular and cellular biology 1994;14(6):3822-33.
1992: R Aloni; D Peleg; Oded Meyuhas
Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver.
Molecular and cellular biology 1992;12(5):2203-12.
1991: S Levy; D Avni; N Hariharan; R P Perry; Oded Meyuhas
Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3319-23.
1990: A Shiran; G Flusser; R Aloni; Oded Meyuhas
The mammalian genome contains a high proportion of processed pseudogenes corresponding to ribosomal protein L19.
Biochemistry international 1990;22(5):921-8.
1990: Oded Meyuhas; A Klein
The mouse ribosomal protein L7 gene. Its primary structure and functional analysis of the promoter region.
The Journal of biological chemistry 1990;265(20):11465-73.
1990: Oded Meyuhas; Véronique Baldin; G Bouche; François Amalric
Glucocorticoids repress ribosome biosynthesis in lymphosarcoma cells by affecting gene expression at the level of transcription, posttranscription and translation.
Biochimica et biophysica acta 1990;1049(1):38-44.
1990: R P Perry; Oded Meyuhas
Translational control of ribosomal protein production in mammalian cells.
Enzyme 1990;44(1-4):83-92.
1989: G Flusser; V Ginzburg; Oded Meyuhas
Glucocorticoids induce transcription of ribosomal protein genes in rat liver.
Molecular and cellular endocrinology 1989;64(2):213-22.
1989: M L Atchison; Oded Meyuhas; R P Perry
Localization of transcriptional regulatory elements and nuclear factor binding sites in mouse ribosomal protein gene rpL32.
Molecular and cellular biology 1989;9(5):2067-74.
1987: A Lin; Y L Chan; J McNally; D Peleg; Oded Meyuhas; I G Wool
The primary structure of rat ribosomal protein L7. The presence near the amino terminus of L7 of five tandem repeats of a sequence of 12 amino acids.
The Journal of biological chemistry 1987;262(26):12665-71.
1987: Oded Meyuhas; E A Thompson; R P Perry
Glucocorticoids selectively inhibit translation of ribosomal protein mRNAs in P1798 lymphosarcoma cells.
Molecular and cellular biology 1987;7(8):2691-9.
1987: Y L Chan; A Lin; J McNally; D Peleg; Oded Meyuhas; I G Wool
The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein.
The Journal of biological chemistry 1987;262(3):1111-5.
1985: L Theodor; D Peleg; Oded Meyuhas
P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes.
Biochimica et biophysica acta 1985;826(2-3):137-46.
1982: P K Geyer; Oded Meyuhas; R P Perry; Lee F Johnson
Regulation of ribosomal protein mRNA content and translation in growth-stimulated mouse fibroblasts.
Molecular and cellular biology 1982;2(6):685-93.
1981: P D'Eustachio; Oded Meyuhas; F Ruddle; R P Perry
Chromosomal distribution of ribosomal protein genes in the mouse.
Cell 1981;24(2):307-12.
1981: R J Monk; Oded Meyuhas; R P Perry
Mammals have multiple genes for individual ribosomal proteins.
Cell 1981;24(2):301-6.
1980: Oded Meyuhas; R P Perry
Construction and identification of cDNA clones for mouse ribosomal proteins: application for the study of r-protein gene expression.
Gene 1980;10(2):113-29.