Flint Beal

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Neymotin Arie; Petri Susanne; Calingasan Noel Y; Wille Elizabeth; Schafer Peter; Stewart Charles; Hensley Kenneth; Beal M Flint; Kiaei Mahmoud
Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis.
Yang Lichuan; Shi Qingli; Ho Daniel J; Starkov Anatoly A; Wille Elizabeth J; Xu Hui; Chen H L; Zhang Steven; Stack Cliona M; Calingasan Noel Y; Gibson Gary E; Beal M Flint
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.
Lee Donna W; Rajagopalan Subramanian; Siddiq Ambreena; Gwiazda Roberto; Yang Lichuan; Beal M Flint; Ratan Rajiv R; Andersen Julie K
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.

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All Publications

2009: Neymotin Arie; Petri Susanne; Calingasan Noel Y; Wille Elizabeth; Schafer Peter; Stewart Charles; Hensley Kenneth; Beal M Flint; Kiaei Mahmoud
Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis.
Experimental neurology 2009;220(1):191-7.
2009: Yang Lichuan; Shi Qingli; Ho Daniel J; Starkov Anatoly A; Wille Elizabeth J; Xu Hui; Chen H L; Zhang Steven; Stack Cliona M; Calingasan Noel Y; Gibson Gary E; Beal M Flint
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.
Neurobiology of disease 2009;36(2):320-30.
2009: Lee Donna W; Rajagopalan Subramanian; Siddiq Ambreena; Gwiazda Roberto; Yang Lichuan; Beal M Flint; Ratan Rajiv R; Andersen Julie K
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
The Journal of biological chemistry 2009;284(42):29065-76.
2009: Dumont Magali; Ho Daniel J; Calingasan Noel Y; Xu Hui; Gibson Gary; Beal M Flint
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.
Free radical biology & medicine 2009;47(7):1019-27.
2009: Karuppagounder Saravanan S; Xu Hui; Shi Qingli; Chen Lian H; Pedrini Steve; Pechman David; Baker Harriet; Beal M Flint; Gandy Sam E; Gibson Gary E
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
Neurobiology of aging 2009;30(10):1587-600.
2009: Chaturvedi Rajnish K; Adhihetty Peter; Shukla Shubha; Hennessy Thomas; Calingasan Noel; Yang Lichuan; Starkov Anatoly; Kiaei Mahmoud; Cannella Milena; Sassone Jenny; Ciammola Andrea; Squitieri Fernando; Beal M Flint
Impaired PGC-1alpha function in muscle in Huntington's disease.
Human molecular genetics 2009;18(16):3048-65.
2009: Dumont Magali; Wille Elizabeth; Stack Cliona; Calingasan Noel Y; Beal M Flint; Lin Michael T
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2459-66.
2009: Li Yanping; Liu Wencheng; Oo Tinmarla F; Wang Lei; Tang Yi; Jackson-Lewis Vernice; Zhou Chun; Geghman Kindiya; Bogdanov Mikhail; Przedborski Serge; Beal M Flint; Burke Robert E; Li Chenjian
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Nature neuroscience 2009;12(7):826-8.
2009: Banerjee Rebecca; Starkov Anatoly A; Beal M Flint; Thomas Bobby
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.
Biochimica et biophysica acta 2009;1792(7):651-63.
2009: Karuppagounder Saravanan S; Pinto John T; Xu Hui; Chen Huan-Lian; Beal M Flint; Gibson Gary E
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Neurochemistry international 2009;54(2):111-8.
2009: Johansen Krisztina K; Wang Lei; Aasly Jan O; White Linda R; Matson Wayne R; Henchcliffe Claire; Beal M Flint; Bogdanov Mikhail
Metabolomic profiling in LRRK2-related Parkinson's disease.
PloS one 2009;4(10):e7551.
2009: Faust Katharina; Gehrke Stephan; Yang Yufeng; Yang Lichuan; Beal M Flint; Lu Bingwei
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease.
BMC neuroscience 2009;10():109.
2009: Yang Lichuan; Calingasan Noel Y; Thomas Bobby; Chaturvedi Rajnish K; Kiaei Mahmoud; Wille Elizabeth J; Liby Karen T; Williams Charlotte; Royce Darlene; Risingsong Renee; Musiek Eric S; Morrow Jason D; Sporn Michael; Beal M Flint
Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.
PloS one 2009;4(6):e5757.
2009: Liu Wencheng; Vives-Bauza Cristofol; Acín-Peréz- Rebeca; Yamamoto Ai; Tan Yingcai; Li Yanping; Magrané Jordi; Stavarache Mihaela A; Shaffer Sebastian; Chang Simon; Kaplitt Michael G; Huang Xin-Yun; Beal M Flint; Manfredi Giovanni; Li Chenjian
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
PloS one 2009;4(2):e4597.
2008: Chaturvedi Rajnish K; Beal M Flint
Mitochondrial approaches for neuroprotection.
Annals of the New York Academy of Sciences 2008;1147():395-412.
2008: Henchcliffe Claire; Shungu Dikoma C; Mao Xiangling; Huang Chaorui; Nirenberg Melissa J; Jenkins Bruce G; Beal M Flint
Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease.
Annals of the New York Academy of Sciences 2008;1147():206-20.
2008: Gibson Gary E; Ratan Rajiv R; Beal M Flint
Mitochondria and oxidative stress in neurodegenerative disorders. Preface.
Annals of the New York Academy of Sciences 2008;1147():xi-xii.
2008: Henchcliffe Claire; Beal M Flint
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis.
Nature clinical practice. Neurology 2008;4(11):600-9.
2008: Akopian Garnik; Crawford Cynthia; Beal M Flint; Cappelletti Maurand; Jakowec Michael W; Petzinger Giselle M; Zheng Ling; Gheorghe Stacey L; Reichel Carmela M; Chow Robert; Walsh John P
Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(38):9585-97.
2008: Chaturvedi Rajnish K; Beal M Flint
PPAR: a therapeutic target in Parkinson's disease.
Journal of neurochemistry 2008;106(2):506-18.
2008: Calingasan N Y; Ho D J; Wille E J; Campagna M V; Ruan J; Dumont M; Yang L; Shi Q; Gibson G E; Beal M F
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.
Neuroscience 2008;153(4):986-96.
2008: Beal M Flint
The urokinase system of plasminogen activator plays a role in amyotrophic lateral sclerosis (ALS) pathogenesis.
Experimental neurology 2008;211(2):332-3.
2008: Yang Yufeng; Ouyang Yingshi; Yang Lichuan; Beal M Flint; McQuibban Angus; Vogel Hannes; Lu Bingwei
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):7070-5.
2008: Yang Lichuan; Calingasan Noel Y; Lorenzo Beverly J; Beal M Flint
Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV.
Experimental neurology 2008;211(1):311-4.
2008: Cleren Carine; Yang Lichuan; Lorenzo Beverly; Calingasan Noel Y; Schomer Andrew; Sireci Anthony; Wille Elizabeth J; Beal M Flint
Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism.
Journal of neurochemistry 2008;104(6):1613-21.
2008: Reddy P Hemachandra; Beal M Flint
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease.
Trends in molecular medicine 2008;14(2):45-53.
2008: Lorenzl Stefan; Buerger Katharina; Hampel Harald; Beal M Flint
Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia.
International psychogeriatrics / IPA 2008;20(1):67-76.
2008: Langley Brett; D'Annibale Melissa A; Suh Kyungsun; Ayoub Issam; Tolhurst Aaron; Bastan Birgül; Yang Lichuan; Ko Brian; Fisher Marc; Cho Sunghee; Beal M Flint; Ratan Rajiv R
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(1):163-76.
2008: Adhihetty Peter J; Beal M Flint
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases.
Neuromolecular medicine 2008;10(4):275-90.
2007: Constantinescu Radu; McDermott Michael P; Dicenzo Robert; de Blieck Elisabeth A; Hyson H Christopher; Beal M Flint; Bednarczyk Edward M; Bogdanov Mikhail; Metakis Linda J; Browne Susan E; Lorenzo Beverly J; Ravina Bernard; Kieburtz Karl
A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone).
Journal of clinical pharmacology 2007;47(12):1580-6.
2007: Stack Edward C; Dedeoglu Alpaslan; Smith Karen M; Cormier Kerry; Kubilus James K; Bogdanov Mikhail; Matson Wayne R; Yang Lichuan; Jenkins Bruce G; Luthi-Carter Ruth; Kowall Neil W; Hersch Steven M; Beal M Flint; Ferrante Robert J
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12908-15.
2007: Strand Andrew D; Baquet Zachary C; Aragaki Aaron K; Holmans Peter; Yang Lichuan; Cleren Carine; Beal M Flint; Jones Lesley; Kooperberg Charles; Olson James M; Jones Kevin R
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(43):11758-68.
2007: Manfredi Giovanni; Beal M Flint
Merging mitochondria for neuronal survival.
Nature medicine 2007;13(10):1140-1.
2007: Thomas Bobby; Beal M Flint
Parkinson's disease.
Human molecular genetics 2007;16 Spec No. 2():R183-94.
2007: Inoue Haruhisa; Lin Ling; Lee Xinhua; Shao Zhaohui; Mendes Shannon; Snodgrass-Belt Pamela; Sweigard Harry; Engber Tom; Pepinsky Blake; Yang Lichuan; Beal M Flint; Mi Sha; Isacson Ole
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14430-5.
2007: Petri Susanne; Calingasan Noel Y; Alsaied Osama A; Wille Elizabeth; Kiaei Mahmoud; Friedman Jonathan E; Baranova Oxana; Chavez Juan C; Beal M Flint
The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2007;102(3):991-1000.
2007: Watanabe Shohei; Nagano Seiichi; Duce James; Kiaei Mahmoud; Li Qiao-Xin; Tucker Stephanie M; Tiwari Ashutosh; Brown Robert H; Beal M Flint; Hayward Lawrence J; Culotta Valeria C; Yoshihara Satoshi; Sakoda Saburo; Bush Ashley I
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
Free radical biology & medicine 2007;42(10):1534-42.
2007: Kiaei Mahmoud; Kipiani Khatuna; Calingasan Noel Y; Wille Elizabeth; Chen Junyu; Heissig Beate; Rafii Shahin; Lorenzl Stefan; Beal M Flint
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology 2007;205(1):74-81.
2007: Goldman Steven A; Roy Neeta S; Beal M Flint; Cleren Carine
Large stem cell grafts could lead to erroneous interpretations of behavioral results?
Nature medicine 2007;13(2):118-9.
2007: Rodriguez M Christine; MacDonald Jay R; Mahoney Douglas J; Parise Gianni; Beal M Flint; Tarnopolsky Mark A
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.
Muscle & nerve 2007;35(2):235-42.
2007: Kim Yoon Seong; Choi Dong Hee; Block Michelle L; Lorenzl Stefan; Yang Lichuan; Kim Youn Jung; Sugama Shuei; Cho Byung Pil; Hwang Onyou; Browne Susan E; Kim Soo Yul; Hong Jau-Shyong; Beal M Flint; Joh Tong H
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):179-87.
2007: Henchcliffe Claire; Beal M Flint
Excitotoxicity.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2007;83():553-69.
2007: Beal M Flint
Mitochondria and neurodegeneration.
Novartis Foundation symposium 2007;287():183-92; discussion 192-6.
2006: Saydoff Joel A; Garcia Rolando A G; Browne Susan E; Liu Liansheng; Sheng Jin; Brenneman Denise; Hu Zhongyi; Cardin Sylvain; Gonzalez Alexis; von Borstel Reid W; Gregorio Jason; Burr Holly; Beal M Flint
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
Neurobiology of disease 2006;24(3):455-65.
2006: Lin Michael T; Beal M Flint
Alzheimer's APP mangles mitochondria.
Nature medicine 2006;12(11):1241-3.
2006: McGill Jetta K; Beal M Flint
PGC-1alpha, a new therapeutic target in Huntington's disease?
Cell 2006;127(3):465-8.
2006: Roy Neeta S; Cleren Carine; Singh Shashi K; Yang Lichuan; Beal M Flint; Goldman Steven A
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.
Nature medicine 2006;12(11):1259-68.
2006: Browne Susan E; Beal M Flint
Oxidative damage in Huntington's disease pathogenesis.
Antioxidants & redox signaling 2006;8(11-12):2061-73.
2006: Lin Michael T; Beal M Flint
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
Nature 2006;443(7113):787-95.
2006: Petri Susanne; Kiaei Mahmoud; Damiano Maria; Hiller Andrew; Wille Elizabeth; Manfredi Giovanni; Calingasan Noel Y; Szeto Hazel H; Beal M Flint
Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2006;98(4):1141-8.
2006: Yang Yufeng; Gehrke Stephan; Imai Yuzuru; Huang Zhinong; Ouyang Yingshi; Wang Ji-Wu; Yang Lichuan; Beal M Flint; Vogel Hannes; Lu Bingwei
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10793-8.
2006: Lorenzl Stefan; Narr Sabine; Angele Barabara; Krell Hans Willi; Gregorio Jason; Kiaei Mahmoud; Pfister Hans-Walter; Beal M Flint
The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice.
Experimental neurology 2006;200(1):166-71.
2006: Kwong Jennifer Q; Beal M Flint; Manfredi Giovanni
The role of mitochondria in inherited neurodegenerative diseases.
Journal of neurochemistry 2006;97(6):1659-75.
2006: Browne Susan E; Yang Lichuan; DiMauro Jon-Paul; Fuller Sara W; Licata Stephanie C; Beal M Flint
Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS.
Neurobiology of disease 2006;22(3):599-610.
2006: Hervias Isabel; Beal M Flint; Manfredi Giovanni
Mitochondrial dysfunction and amyotrophic lateral sclerosis.
Muscle & nerve 2006;33(5):598-608.
2006: Elson Joanna L; Herrnstadt Corinna; Preston Gwen; Thal Leon; Morris Christopher M; Edwardson J A; Beal M Flint; Turnbull Douglass M; Howell Neil
Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?
Human genetics 2006;119(3):241-54.
2006: Petri Susanne; Kiaei Mahmoud; Kipiani Khatuna; Chen Junyu; Calingasan Noel Y; Crow John P; Beal M Flint
Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis.
Neurobiology of disease 2006;22(1):40-9.
2006: Kiaei Mahmoud; Petri Susanne; Kipiani Khatuna; Gardian Gabrielle; Choi Dong-Kug; Chen Junyu; Calingasan Noel Y; Schafer Peter; Muller George W; Stewart Charles; Hensley Kenneth; Beal M Flint
Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(9):2467-73.
2006: Klivenyi Peter; Siwek Donald; Gardian Gabrielle; Yang Lichuan; Starkov Anatoly; Cleren Carine; Ferrante Robert J; Kowall Neil W; Abeliovich Asa; Beal M Flint
Mice lacking alpha-synuclein are resistant to mitochondrial toxins.
Neurobiology of disease 2006;21(3):541-8.
2006: Hersch S M; Gevorkian S; Marder K; Moskowitz C; Feigin A; Cox M; Como P; Zimmerman C; Lin M; Zhang L; Ulug A M; Beal M F; Matson W; Bogdanov M; Ebbel E; Zaleta A; Kaneko Y; Jenkins B; Hevelone N; Zhang H; Yu H; Schoenfeld D; Ferrante R; Rosas H D
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.
Neurology 2006;66(2):250-2.
2005: Ferrante K L; Shefner J; Zhang H; Betensky R; O'Brien M; Yu H; Fantasia M; Taft J; Beal M F; Traynor B; Newhall K; Donofrio P; Caress J; Ashburn C; Freiberg B; O'Neill C; Paladenech C; Walker T; Pestronk A; Abrams B; Florence J; Renna R; Schierbecker J; Malkus B; Cudkowicz M
Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.
Neurology 2005;65(11):1834-6.
2005: Cleren Carine; Starkov Anatoly A; Calingasan Noel Y; Lorenzo Beverly J; Chen Junya; Beal M Flint
Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Neurobiology of disease 2005;20(3):701-8.
2005: Li Chenjian; Beal M Flint
Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16535-6.
2005: Reddy P Hemachandra; Beal M Flint
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
Brain research. Brain research reviews 2005;49(3):618-32.
2005: Nathan Carl; Calingasan Noel; Nezezon Jon; Ding Aihao; Lucia M Scott; La Perle Krista; Fuortes Michele; Lin Michael; Ehrt Sabine; Kwon Nyoun Soo; Chen Junyu; Vodovotz Yoram; Kipiani Khatuna; Beal M Flint
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
The Journal of experimental medicine 2005;202(9):1163-9.
2005: Cantuti-Castelvetri Ippolita; Lin Michael T; Zheng Kangni; Keller-McGandy Christine E; Betensky Rebecca A; Johns Donald R; Beal M Flint; Standaert David G; Simon David K
Somatic mitochondrial DNA mutations in single neurons and glia.
Neurobiology of aging 2005;26(10):1343-55.
2005: Kim Soo-Youl; Marekov Lyuben; Bubber Parvesh; Browne Susan E; Stavrovskaya Irina; Lee Jongmin; Steinert Peter M; Blass John P; Beal M Flint; Gibson Gary E; Cooper Arthur J L
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Neurochemical research 2005;30(10):1245-55.
2005: Beal M Flint
Mitochondria take center stage in aging and neurodegeneration.
Annals of neurology 2005;58(4):495-505.
2005: Jenkins Bruce G; Andreassen Ole A; Dedeoglu Alpaslan; Leavitt Blair; Hayden Michael; Borchelt David; Ross Christopher A; Ferrante Robert J; Beal M Flint
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Journal of neurochemistry 2005;95(2):553-62.
2005: Kleiner-Fisman Galit; Calingasan Noel Y; Putt Mary; Chen June; Beal M Flint; Lang Anthony E
Alterations of striatal neurons in benign hereditary chorea.
Movement disorders : official journal of the Movement Disorder Society 2005;20(10):1353-7.
2005: Yang Yufeng; Gehrke Stephan; Haque Md Emdadul; Imai Yuzuru; Kosek Jon; Yang Lichuan; Beal M Flint; Nishimura Isao; Wakamatsu Kazumasa; Ito Shosuke; Takahashi Ryosuke; Lu Bingwei
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13670-5.
2005: Son Jin H; Kawamata Hibiki; Yoo Myung S; Kim Dae J; Lee Young K; Kim Sooyoul; Dawson Ted M; Zhang Hui; Sulzer David; Yang Lichuan; Beal M Flint; Degiorgio Lorraine A; Chun Hong S; Baker Harriet; Peng Chu
Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.
Journal of neurochemistry 2005;94(4):1040-53.
2005: Cleren Carine; Calingasan Noel Y; Chen Junya; Beal M Flint
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.
Journal of neurochemistry 2005;94(4):995-1004.
2005: Crow John P; Calingasan Noel Y; Chen Junyu; Hill Julie Lynch; Beal M Flint
Manganese porphyrin given at symptom onset markedly extends survival of ALS mice.
Annals of neurology 2005;58(2):258-65.
2005: Beal M Flint
Less stress, longer life.
Nature medicine 2005;11(6):598-9.
2005: Calingasan Noel Y; Chen Junyu; Kiaei Mahmoud; Beal M Flint
Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients.
Neurobiology of disease 2005;19(1-2):340-7.
2005: Beal M Flint
Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment.
Neurobiology of aging 2005;26(5):585-6.
2005: Aguirre Norberto; Beal M Flint; Matson Wayne R; Bogdanov Mikhail B
Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis.
Free radical research 2005;39(4):383-8.
2005: Kiaei Mahmoud; Kipiani Khatuna; Petri Susanne; Choi Dong-Kug; Chen Junyu; Calingasan Noel Y; Beal M Flint
Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2005;93(2):403-11.
2005: Kim Yoon Seong; Kim Sung Soo; Cho Jeong Je; Choi Dong Hee; Hwang Onyou; Shin Dong Hoon; Chun Hong Sung; Beal M Flint; Joh Tong H
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(14):3701-11.
2005: Vijayvergiya Chetan; Beal M Flint; Buck Jochen; Manfredi Giovanni
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2463-70.
2005: Langley Brett; Gensert Joann M; Beal M Flint; Ratan Rajiv R
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Current drug targets. CNS and neurological disorders 2005;4(1):41-50.
2005: Kiaei Mahmoud; Kipiani Khatuna; Chen Junyu; Calingasan Noel Y; Beal M Flint
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology 2005;191(2):331-6.
2005: Andrews Zane B; Horvath Balazs; Barnstable Colin J; Elsworth John; Yang Lichuan; Beal M Flynt; Roth Robert H; Matthews Russell T; Horvath Tamas L
Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(1):184-91.
2005: Yang Lichuan; Calingasan Noel Y; Chen Junyu; Ley James J; Becker David A; Beal M Flint
A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities.
Experimental neurology 2005;191(1):86-93.
2005: Gardian Gabriella; Browne Susan E; Choi Dong-Kug; Klivenyi Peter; Gregorio Jason; Kubilus James K; Ryu Hoon; Langley Brett; Ratan Rajiv R; Ferrante Robert J; Beal M Flint
Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.
The Journal of biological chemistry 2005;280(1):556-63.
2005: Kiaei Mahmoud; Kipiani Khatuna; Petri Susanne; Chen Junyu; Calingasan Noel Y; Beal M Flint
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis.
Neuro-degenerative diseases 2005;2(5):246-54.
2005: Gibson Gary E; Blass John P; Beal M Flint; Bunik Victoria
The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.
Molecular neurobiology 2005;31(1-3):43-63.
2004: Ferrante Robert J; Ryu Hoon; Kubilus James K; D'Mello Santosh; Sugars Katharine L; Lee Junghee; Lu Peiyuan; Smith Karen; Browne Susan; Beal M Flint; Kristal Bruce S; Stavrovskaya Irina G; Hewett Sandra; Rubinsztein David C; Langley Brett; Ratan Rajiv R
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(46):10335-42.
2004: Martinat Cecile; Shendelman Shoshana; Jonason Alan; Leete Thomas; Beal M Flint; Yang Lichuan; Floss Thomas; Abeliovich Asa
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.
PLoS biology 2004;2(11):e327.
2004: Yang Lichuan; Sugama Shuei; Mischak Ronald P; Kiaei Mahmoud; Bizat Nicolas; Brouillet Emmanuel; Joh Tong H; Beal M Flint
A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo.
Neurobiology of disease 2004;17(2):250-9.
2004: Kiaei Mahmoud; Bush Ashley I; Morrison Brett M; Morrison John H; Cherny Robert A; Volitakis Irene; Beal M Flint; Gordon Jon W
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7945-50.
2004: Starkov Anatoly A; Fiskum Gary; Chinopoulos Christos; Lorenzo Beverly J; Browne Susan E; Patel Mulchand S; Beal M Flint
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7779-88.
2004: Beal M Flint
Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment.
Journal of bioenergetics and biomembranes 2004;36(4):381-6.
2004: Kristal Bruce S; Stavrovskaya Irina G; Narayanan Malini V; Krasnikov Boris F; Brown Abraham M; Beal M Flint; Friedlander Robert M
The mitochondrial permeability transition as a target for neuroprotection.
Journal of bioenergetics and biomembranes 2004;36(4):309-12.
2004: Manfredi Giovanni; Beal M Flint
Poison and antidote: a novel model to study pathogenesis and therapy of LHON.
Annals of neurology 2004;56(2):171-2.
2004: Stavrovskaya Irina G; Narayanan Malini V; Zhang Wenhua; Krasnikov Boris F; Heemskerk Jill; Young S Stanley; Blass John P; Brown Abraham M; Beal M Flint; Friedlander Robert M; Kristal Bruce S
Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.
The Journal of experimental medicine 2004;200(2):211-22.
2004: Coskun Pinar E; Beal M Flint; Wallace Douglas C
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10726-31.
2004: Zhu Shan; Li Mingwei; Figueroa Bryan E; Liu Aijian; Stavrovskaya Irina G; Pasinelli Piera; Beal M Flint; Brown Robert H; Kristal Bruce S; Ferrante Robert J; Friedlander Robert M
Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(26):5909-12.
2004: Brownell Anna-Liisa; Chen Y Iris; Yu Meixiang; Wang Xukui; Dedeoglu Alpaslan; Cicchetti Francesca; Jenkins Bruce G; Beal M Flint
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Journal of neurochemistry 2004;89(5):1206-14.
2004: Shults Clifford W; Haas Richard; Oakes David; Kieburtz Karl; Plumb Sandra; Shoulson Ira; Beal M Flint; Juncos Jorge; Nutt John
Measuring the effects of therapy in Parkinson disease.
JAMA : the journal of the American Medical Association 2004;291(20):2430-1; author reply 2431.
2004: Beal M Flint; Ferrante Robert J
Experimental therapeutics in transgenic mouse models of Huntington's disease.
Nature reviews. Neuroscience 2004;5(5):373-84.
2004: Klivenyi Peter; Calingasan Noel Y; Starkov Anatoly; Stavrovskaya Irina G; Kristal Bruce S; Yang Lichuan; Wieringa Bé; Beal M Flint
Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase.
Neurobiology of disease 2004;15(3):610-7.
2004: Beal M Flint
Commentary on "Alpha-synuclein and mitochondria: a tangled skein".
Experimental neurology 2004;186(2):109-11.
2004: Browne Susan E; Roberts L Jackson; Dennery Phyllis A; Doctrow Susan R; Beal M Flint; Barlow Carrolee; Levine Rodney L
Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.
Free radical biology & medicine 2004;36(7):938-42.
2004: Browne Susan E; Beal M Flint
The energetics of Huntington's disease.
Neurochemical research 2004;29(3):531-46.
2004: Klivenyi Peter; Starkov Anatoly A; Calingasan Noel Y; Gardian Gabrielle; Browne Susan E; Yang Lichuan; Bubber Parvesh; Gibson Gary E; Patel Mulchand S; Beal M Flint
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Journal of neurochemistry 2004;88(6):1352-60.
2004: Lorenzl Stefan; Albers David S; Chirichigno Jason W; Augood Sarah J; Beal M Flint
Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy.
Journal of the neurological sciences 2004;218(1-2):39-45.
2004: Klivenyi Peter; Kiaei Mahmoud; Gardian Gabrielle; Calingasan Noel Y; Beal M Flint
Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2004;88(3):576-82.
2004: Ulug Aziz M; Grünewald Thomas; Lin Michael T; Kamal Ayeesha K; Filippi Christopher G; Zimmerman Robert D; Beal M Flint
Diffusion tensor imaging in the diagnosis of primary lateral sclerosis.
Journal of magnetic resonance imaging : JMRI 2004;19(1):34-9.
2004: Simon David K; Lin Michael T; Zheng Leiya; Liu Guang-Jun; Ahn Colette H; Kim Lauren M; Mauck William M; Twu Florence; Beal M Flint; Johns Donald R
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
Neurobiology of aging 2004;25(1):71-81.
2004: Klivenyi Peter; Gardian Gabrielle; Calingasan Noel Y; Yang Lichuan; von Borstel Reid; Saydoff Joel; Browne Susan E; Beal M Flint
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.
Neuromolecular medicine 2004;6(2-3):87-92.
2004: Gardian Gabriella; Yang Lichuan; Cleren Carine; Calingasan Noel Y; Klivenyi Peter; Beal M Flint
Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity.
Neuromolecular medicine 2004;5(3):235-41.
2004: Lorenzl Stefan; Calingasan Noel; Yang Lichuan; Albers David S; Shugama Shuei; Gregorio Jason; Krell H W; Chirichigno Jason; Joh Tong; Beal M Flint
Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Neuromolecular medicine 2004;5(2):119-32.
2004: Beal M Flint
Therapeutic effects of coenzyme Q10 in neurodegenerative diseases.
Methods in enzymology 2004;382():473-87.
2003: Diano Sabrina; Matthews Russell T; Patrylo Peter; Yang Lichuan; Beal M Flint; Barnstable Colin J; Horvath Tamas L
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.
Endocrinology 2003;144(11):5014-21.
2003: Yang Lichuan; Sugama Shuei; Chirichigno Jason W; Gregorio Jason; Lorenzl Stefan; Shin Dong H; Browne Susan E; Shimizu Yoshinori; Joh Tong H; Beal M Flint; Albers David S
Minocycline enhances MPTP toxicity to dopaminergic neurons.
Journal of neuroscience research 2003;74(2):278-85.
2003: Barberi Tiziano; Klivenyi Peter; Calingasan Noel Y; Lee Hyojin; Kawamata Hibiki; Loonam Kathleen; Perrier Anselme L; Bruses Juan; Rubio Maria E; Topf Norbert; Tabar Viviane; Harrison Neil L; Beal M Flint; Moore Malcolm A S; Studer Lorenz
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.
Nature biotechnology 2003;21(10):1200-7.
2003: Lorenzl Stefan; Albers David S; Relkin Norman; Ngyuen Terry; Hilgenberg Sarah L; Chirichigno Jason; Cudkowicz Merit E; Beal M Flint
Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.
Neurochemistry international 2003;43(3):191-6.
2003: Klivenyi Peter; Ferrante Robert J; Gardian Gabrielle; Browne Susan; Chabrier Pierre-Etienne; Beal M Flint
Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease.
Journal of neurochemistry 2003;86(1):267-72.
2003: Beal M Flint
Mitochondria, oxidative damage, and inflammation in Parkinson's disease.
Annals of the New York Academy of Sciences 2003;991():120-31.
2003: Dedeoglu Alpaslan; Kubilus James K; Yang Lichuan; Ferrante Kimberly L; Hersch Steven M; Beal M Flint; Ferrante Robert J
Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice.
Journal of neurochemistry 2003;85(6):1359-67.
2003: Lorenzl Stefan; De Pasquale Giovanni; Segal Alan Z; Beal M Flint
Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia.
Stroke; a journal of cerebral circulation 2003;34(6):e37-8; author reply e37-8.
2003: Paul Simon; Bogdanov Mikhail B; Matson Wayne R; Metakis Linda; Jacobs Jonathan; Beal M Flint
Urinary 8-hydroxy-2'-deoxyguanosine, a metabolite of oxidized DNA, is not elevated in HIV patients on combination antiretroviral therapy.
Free radical research 2003;37(5):499-502.
2003: Zhang Lijuan; Ulug Aziz M; Zimmerman Robert D; Lin Michael T; Rubin Michael; Beal M Flint
The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis.
Journal of magnetic resonance imaging : JMRI 2003;17(5):521-7.
2003: Wu Annie S; Kiaei Mahmoud; Aguirre Norberto; Crow John P; Calingasan Noel Y; Browne Susan E; Beal M Flint
Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2003;85(1):142-50.
2003: Kaur Deepinder; Yantiri Ferda; Rajagopalan Subramanian; Kumar Jyothi; Mo Jun Qin; Boonplueang Rapee; Viswanath Veena; Jacobs Russell; Yang Lichuan; Beal M Flint; DiMonte Dino; Volitaskis Irene; Ellerby Lisa; Cherny Robert A; Bush Ashley I; Andersen Julie K
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.
Neuron 2003;37(6):899-909.
2003: Lorenzl S; Albers D S; LeWitt P A; Chirichigno J W; Hilgenberg S L; Cudkowicz M E; Beal M F
Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases.
Journal of the neurological sciences 2003;207(1-2):71-6.
2003: Gajewski Carl D; Lin Michael T; Cudkowicz Merit E; Beal M Flint; Manfredi Giovanni
Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.
Experimental neurology 2003;179(2):229-35.
2003: Sugama Shuei; Yang Lichuan; Cho Byung Pil; DeGiorgio Lorraine A; Lorenzl Stefan; Albers David S; Beal M Flint; Volpe Bruce T; Joh Tong H
Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice.
Brain research 2003;964(2):288-94.
2003: Beal M Flint; Shults Clifford W
Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease.
BioFactors (Oxford, England) 2003;18(1-4):153-61.
2003: Klivenyi Peter; Gardian Gabrielle; Calingasan Noel Y; Yang Lichuan; Beal M Flint
Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Journal of molecular neuroscience : MN 2003;21(3):191-8.
2003: Andreassen O A; Ferrante R J; Aamo T O; Beal M F; Jørgensen H A
Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats.
Neuroscience 2003;122(3):717-25.
2003: Beal M Flint
Bioenergetic approaches for neuroprotection in Parkinson's disease.
Annals of neurology 2003;53 Suppl 3():S39-47; discussion S47-8.
2002: Andreassen Ole A; Dedeoglu Alpaslan; Stanojevic Violeta; Hughes Duncan B; Browne Susan E; Leech Colin A; Ferrante Robert J; Habener Joel F; Beal M Flint; Thomas Melissa K
Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression.
Neurobiology of disease 2002;11(3):410-24.
2002: Lorenzl Stefan; Albers David S; Narr Sabine; Chirichigno Jason; Beal M Flint
Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease.
Experimental neurology 2002;178(1):13-20.
2002: Takahashi Reisuke H; Milner Teresa A; Li Feng; Nam Ellen E; Edgar Mark A; Yamaguchi Haruyasu; Beal M Flint; Xu Huaxi; Greengard Paul; Gouras Gunnar K
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology 2002;161(5):1869-79.
2002: Dedeoglu Alpaslan; Kubilus James K; Jeitner Thomas M; Matson Samantha A; Bogdanov Misha; Kowall Neil W; Matson Wayne R; Cooper Arthur J L; Ratan Rajiv R; Beal M Flint; Hersch Steven M; Ferrante Robert J
Therapeutic effects of cystamine in a murine model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(20):8942-50.
2002: Shults Clifford W; Oakes David; Kieburtz Karl; Beal M Flint; Haas Richard; Plumb Sandy; Juncos Jorge L; Nutt John; Shoulson Ira; Carter Julie; Kompoliti Katie; Perlmutter Joel S; Reich Stephen; Stern Matthew; Watts Ray L; Kurlan Roger; Molho Eric; Harrison Madaline; Lew Mark;
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
Archives of neurology 2002;59(10):1541-50.
2002: Chirichigno Jason W; Manfredi Giovanni; Beal M Flint; Albers David S
Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids.
Brain research 2002;951(1):31-5.
2002: Montine Thomas J; Neely M Diana; Quinn Joseph F; Beal M Flint; Markesbery William R; Roberts L Jackson; Morrow Jason D
Lipid peroxidation in aging brain and Alzheimer's disease.
Free radical biology & medicine 2002;33(5):620-6.
2002: Mattiazzi Marina; D'Aurelio Marilena; Gajewski Carl D; Martushova Katherine; Kiaei Mahmoud; Beal M Flint; Manfredi Giovanni
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.
The Journal of biological chemistry 2002;277(33):29626-33.
2002: Dedeoglu Alpaslan; Ferrante Robert J; Andreassen Ole A; Dillmann Wolfgang H; Beal M Flint
Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid.
Experimental neurology 2002;176(1):262-5.
2002: Mecocci Patrizia; Polidori M Cristina; Cherubini Antonio; Ingegni Tiziana; Mattioli Paola; Catani Marco; Rinaldi Patrizia; Cecchetti Roberta; Stahl Wilhelm; Senin Umberto; Beal M Flint
Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease.
Archives of neurology 2002;59(5):794-8.
2002: Wendt Silke; Dedeoglu Alpaslan; Speer Oliver; Wallimann Theo; Beal M Flint; Andreassen Ole A
Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice.
Free radical biology & medicine 2002;32(9):920-6.
2002: Beal M Flint
Oxidatively modified proteins in aging and disease.
Free radical biology & medicine 2002;32(9):797-803.
2002: Herrnstadt Corinna; Elson Joanna L; Fahy Eoin; Preston Gwen; Turnbull Douglass M; Anderson Christen; Ghosh Soumitra S; Olefsky Jerrold M; Beal M Flint; Davis Robert E; Howell Neil
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.
American journal of human genetics 2002;70(5):1152-71.
2002: Albers David S; Beal M Flint
Mitochondrial dysfunction in progressive supranuclear palsy.
Neurochemistry international 2002;40(6):559-64.
2002: Beal M Flint
Coenzyme Q10 as a possible treatment for neurodegenerative diseases.
Free radical research 2002;36(4):455-60.
2002: Ferrante Robert J; Andreassen Ole A; Dedeoglu Alpaslan; Ferrante Kimberly L; Jenkins Bruce G; Hersch Steven M; Beal M Flint
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1592-9.
2002: Cantuti-Castelvetri Ippolita; Keller-McGandy Christine E; Albers David S; Beal M Flint; Vonsattel Jean Paul; Standaert David G; Augood Sarah J
Expression and activity of antioxidants in the brain in progressive supranuclear palsy.
Brain research 2002;930(1-2):170-81.
2002: Wiedemann Falk R; Manfredi Giovanni; Mawrin Christian; Beal M Flint; Schon Eric A
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients.
Journal of neurochemistry 2002;80(4):616-25.
2002: Vives-Bauza Cristofol; Andreu Antoni L; Manfredi Giovanni; Beal M Flint; Janetzky Bernd; Gruenewald Thomas H; Lin Michael T
Sequence analysis of the entire mitochondrial genome in Parkinson's disease.
Biochemical and biophysical research communications 2002;290(5):1593-601.
2002: Lin Michael T; Simon David K; Ahn Colette H; Kim Lauren M; Beal M Flint
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.
Human molecular genetics 2002;11(2):133-45.
2002: Browne Susan E; Beal M Flint
Toxin-induced mitochondrial dysfunction.
International review of neurobiology 2002;53():243-79.
2002: Kiechle Tamara; Dedeoglu Alpaslan; Kubilus James; Kowall Neil W; Beal M Flint; Friedlander Robert M; Hersch Steven M; Ferrante Robert J
Cytochrome C and caspase-9 expression in Huntington's disease.
Neuromolecular medicine 2002;1(3):183-95.
2001: Bogdanov M B; Andreassen O A; Dedeoglu A; Ferrante R J; Beal M F
Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease.
Journal of neurochemistry 2001;79(6):1246-9.
2001: Park L C; Albers D S; Xu H; Lindsay J G; Beal M F; Gibson G E
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy.
Journal of neuroscience research 2001;66(5):1028-34.
2001: Jeitner T M; Bogdanov M B; Matson W R; Daikhin Y; Yudkoff M; Folk J E; Steinman L; Browne S E; Beal M F; Blass J P; Cooper A J
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.
Journal of neurochemistry 2001;79(5):1109-12.
2001: Viswanath V; Wu Y; Boonplueang R; Chen S; Stevenson F F; Yantiri F; Yang L; Beal M F; Andersen J K
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9519-28.
2001: D'Aurelio M; Pallotti F; Barrientos A; Gajewski C D; Kwong J Q; Bruno C; Beal M F; Manfredi G
In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I.
The Journal of biological chemistry 2001;276(50):46925-32.
2001: Andreassen O A; Ferrante R J; Dedeoglu A; Beal M F
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
Neuroreport 2001;12(15):3371-3.
2001: Rosas H D; Goodman J; Chen Y I; Jenkins B G; Kennedy D N; Makris N; Patti M; Seidman L J; Beal M F; Koroshetz W J
Striatal volume loss in HD as measured by MRI and the influence of CAG repeat.
Neurology 2001;57(6):1025-8.
2001: Ferrante R J; Klein A M; Dedeoglu A; Beal M F
Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of molecular neuroscience : MN 2001;17(1):89-96.
2001: Andreassen O A; Ferrante R J; Huang H M; Dedeoglu A; Park L; Ferrante K L; Kwon J; Borchelt D R; Ross C A; Gibson G E; Beal M F
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.
Annals of neurology 2001;50(1):112-7.
2001: Andreassen O A; Dedeoglu A; Ferrante R J; Jenkins B G; Ferrante K L; Thomas M; Friedlich A; Browne S E; Schilling G; Borchelt D R; Hersch S M; Ross C A; Beal M F
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Neurobiology of disease 2001;8(3):479-91.
2001: Gouras G K; Beal M F
Metal chelator decreases Alzheimer beta-amyloid plaques.
Neuron 2001;30(3):641-2.
2001: Tarnopolsky M A; Beal M F
Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders.
Annals of neurology 2001;49(5):561-74.
2001: Beal M F
Experimental models of Parkinson's disease.
Nature reviews. Neuroscience 2001;2(5):325-34.
2001: Simon D K; Lin M T; Ahn C H; Liu G J; Gibson G E; Beal M F; Johns D R
Low mutational burden of individual acquired mitochondrial DNA mutations in brain.
Genomics 2001;73(1):113-6.
2001: Gasparini L; Gouras G K; Wang R; Gross R S; Beal M F; Greengard P; Xu H
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(8):2561-70.
2001: Andreassen O A; Jenkins B G; Dedeoglu A; Ferrante K L; Bogdanov M B; Kaddurah-Daouk R; Beal M F
Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Journal of neurochemistry 2001;77(2):383-90.
2001: Andreassen O A; Dedeoglu A; Friedlich A; Ferrante K L; Hughes D; Szabo C; Beal M F
Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.
Experimental neurology 2001;168(2):419-24.
2001: Andreassen O A; Ferrante R J; Klivenyi P; Klein A M; Dedeoglu A; Albers D S; Kowall N W; Beal M F
Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid.
Experimental neurology 2001;168(2):356-63.
2001: Albers D S; Swerdlow R H; Manfredi G; Gajewski C; Yang L; Parker W D; Beal M F
Further evidence for mitochondrial dysfunction in progressive supranuclear palsy.
Experimental neurology 2001;168(1):196-8.
2001: Andreassen O A; Ferrante R J; Dedeoglu A; Albers D W; Klivenyi P; Carlson E J; Epstein C J; Beal M F
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.
Experimental neurology 2001;167(1):189-95.
2001: Beal M F; Hantraye P
Novel therapies in the search for a cure for Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):3-4.
2001: Beal M F
Mitochondria and oxidative damage in amyotrophic lateral sclerosis.
Functional neurology 2001;16(4 Suppl):161-9.
2001: Fanò G; Mecocci P; Vecchiet J; Belia S; Fulle S; Polidori M C; Felzani G; Senin U; Vecchiet L; Beal M F
Age and sex influence on oxidative damage and functional status in human skeletal muscle.
Journal of muscle research and cell motility 2001;22(4):345-51.
2000: Fulle S; Mecocci P; Fanó G; Vecchiet I; Vecchini A; Racciotti D; Cherubini A; Pizzigallo E; Vecchiet L; Senin U; Beal M F
Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.
Free radical biology & medicine 2000;29(12):1252-9.
2000: Montine T J; Shinobu L; Montine K S; Roberts L J; Kowall N W; Beal M F; Morrow J D
No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls.
Annals of neurology 2000;48(6):950.
2000: Schulz J B; Dehmer T; Schöls L; Mende H; Hardt C; Vorgerd M; Bürk K; Matson W; Dichgans J; Beal M F; Bogdanov M B
Oxidative stress in patients with Friedreich ataxia.
Neurology 2000;55(11):1719-21.
2000: Kuntz C; Kinoshita Y; Beal M F; Donehower L A; Morrison R S
Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Experimental neurology 2000;165(1):184-90.
2000: Andreassen O A; Dedeoglu A; Klivenyi P; Beal M F; Bush A I
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis.
Neuroreport 2000;11(11):2491-3.
2000: Andreassen O A; Ferrante R J; Hughes D B; Klivenyi P; Dedeoglu A; Ona V O; Friedlander R M; Beal M F
Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.
Journal of neurochemistry 2000;75(2):847-52.
2000: Manfredi G; Beal M F
The role of mitochondria in the pathogenesis of neurodegenerative diseases.
Brain pathology (Zurich, Switzerland) 2000;10(3):462-72.
2000: Beal M F
Mitochondria and the pathogenesis of ALS.
Brain : a journal of neurology 2000;123 ( Pt 7)():1291-2.
2000: Beal M F
Energetics in the pathogenesis of neurodegenerative diseases.
Trends in neurosciences 2000;23(7):298-304.
2000: Ferrante R J; Andreassen O A; Jenkins B G; Dedeoglu A; Kuemmerle S; Kubilus J K; Kaddurah-Daouk R; Hersch S M; Beal M F
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(12):4389-97.
2000: Beal M F
Limited-time exposure to mitochondrial toxins may lead to chronic progressive neurodegenerative diseases.
Movement disorders : official journal of the Movement Disorder Society 2000;15(3):434-5.
2000: Jenkins B G; Klivenyi P; Kustermann E; Andreassen O A; Ferrante R J; Rosen B R; Beal M F
Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.
Journal of neurochemistry 2000;74(5):2108-19.
2000: Klivenyi P; Andreassen O A; Ferrante R J; Lancelot E; Reif D; Beal M F
Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity.
Neuroreport 2000;11(6):1265-8.
2000: Andreassen O A; Ferrante R J; Klivenyi P; Klein A M; Shinobu L A; Epstein C J; Beal M F
Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis.
Annals of neurology 2000;47(4):447-55.
2000: Malcon C; Kaddurah-Daouk R; Beal M F
Neuroprotective effects of creatine administration against NMDA and malonate toxicity.
Brain research 2000;860(1-2):195-8.
2000: Simon D K; Mayeux R; Marder K; Kowall N W; Beal M F; Johns D R
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease.
Neurology 2000;54(3):703-9.
2000: Albers D S; Augood S J; Park L C; Browne S E; Martin D M; Adamson J; Hutton M; Standaert D G; Vonsattel J P; Gibson G E; Beal M F
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment.
Journal of neurochemistry 2000;74(2):878-81.
2000: Kowall N W; Hantraye P; Brouillet E; Beal M F; McKee A C; Ferrante R J
MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.
Neuroreport 2000;11(1):211-3.
2000: Klivenyi P; Andreassen O A; Ferrante R J; Dedeoglu A; Mueller G; Lancelot E; Bogdanov M; Andersen J K; Jiang D; Beal M F
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(1):1-7.
2000: Friedlich A L; Beal M F
Prospects for redox-based therapy in neurodegenerative diseases.
Neurotoxicity research 2000;2(2-3):229-37.
2000: Beal M F; Palomo T; Kostrzewa R M; Archer T
Neuroprotective and neurorestorative strategies for neuronal injury.
Neurotoxicity research 2000;2(2-3):71-84.
2000: Beal M F
Oxidative metabolism.
Annals of the New York Academy of Sciences 2000;924():164-9.
2000: Albers D S; Beal M F
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease.
Journal of neural transmission. Supplementum 2000;59():133-54.
1999: Kuemmerle S; Gutekunst C A; Klein A M; Li X J; Li S H; Beal M F; Hersch S M; Ferrante R J
Huntington aggregates may not predict neuronal death in Huntington's disease.
Annals of neurology 1999;46(6):842-9.
1999: Grünewald T; Beal M F
NOS knockouts and neuroprotection.
Nature medicine 1999;5(12):1354-5.
1999: Brouillet E; Condé F; Beal M F; Hantraye P
Replicating Huntington's disease phenotype in experimental animals.
Progress in neurobiology 1999;59(5):427-68.
1999: Simon D K; Pulst S M; Sutton J P; Browne S E; Beal M F; Johns D R
Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation.
Neurology 1999;53(8):1787-93.
1999: Chen Y I; Brownell A L; Galpern W; Isacson O; Bogdanov M; Beal M F; Livni E; Rosen B R; Jenkins B G
Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.
Neuroreport 1999;10(14):2881-6.
1999: Polidori M C; Mecocci P; Browne S E; Senin U; Beal M F
Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex.
Neuroscience letters 1999;272(1):53-6.
1999: Bogdanov M B; Beal M F; McCabe D R; Griffin R M; Matson W R
A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods.
Free radical biology & medicine 1999;27(5-6):647-66.
1999: Cherubini A; Beal M F; Frei B
Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo.
Free radical biology & medicine 1999;27(3-4):381-7.
1999: Dautry C; Condé F; Brouillet E; Mittoux V; Beal M F; Bloch G; Hantraye P
Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.
Neurobiology of disease 1999;6(4):259-68.
1999: Albers D S; Augood S J; Martin D M; Standaert D G; Vonsattel J P; Beal M F
Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy.
Journal of neurochemistry 1999;73(2):881-4.
1999: Lezza A M; Mecocci P; Cormio A; Beal M F; Cherubini A; Cantatore P; Senin U; Gadaleta M N
Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(9):1083-8.
1999: Litt L; Espanol M T; Hasegawa K; Chang L H; Gregory G A; James T L; Beal M F; Chan P H
NOS inhibitors decrease hypoxia-induced ATP reductions in respiring cerebrocortical slices.
Anesthesiology 1999;90(5):1392-401.
1999: Matthews R T; Ferrante R J; Klivenyi P; Yang L; Klein A M; Mueller G; Kaddurah-Daouk R; Beal M F
Creatine and cyclocreatine attenuate MPTP neurotoxicity.
Experimental neurology 1999;157(1):142-9.
1999: Matthews R T; Klivenyi P; Mueller G; Yang L; Wermer M; Thomas C E; Beal M F
Novel free radical spin traps protect against malonate and MPTP neurotoxicity.
Experimental neurology 1999;157(1):120-6.
1999: Fiskum G; Murphy A N; Beal M F
Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(4):351-69.
1999: Montine T J; Beal M F; Robertson D; Cudkowicz M E; Biaggioni I; O'Donnell H; Zackert W E; Roberts L J; Morrow J D
Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease.
Neurology 1999;52(5):1104-5.
1999: Ferrante R J; Hantraye P; Brouillet E; Beal M F
Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase.
Brain research 1999;823(1-2):177-82.
1999: Rosas H D; Koroshetz W J; Jenkins B G; Chen Y I; Hayden D L; Beal M F; Cudkowicz M E
Riluzole therapy in Huntington's disease (HD).
Movement disorders : official journal of the Movement Disorder Society 1999;14(2):326-30.
1999: Klivenyi P; Ferrante R J; Matthews R T; Bogdanov M B; Klein A M; Andreassen O A; Mueller G; Wermer M; Kaddurah-Daouk R; Beal M F
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Nature medicine 1999;5(3):347-50.
1999: Murphy A N; Fiskum G; Beal M F
Mitochondria in neurodegeneration: bioenergetic function in cell life and death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(3):231-45.
1999: Klevenyi P; Andreassen O; Ferrante R J; Schleicher J R; Friedlander R M; Beal M F
Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.
Neuroreport 1999;10(3):635-8.
1999: Bogdanov M B; Ferrante R J; Mueller G; Ramos L E; Martinou J C; Beal M F
Oxidative stress is attenuated in mice overexpressing BCL-2.
Neuroscience letters 1999;262(1):33-6.
1999: Browne S E; Ayata C; Huang P L; Moskowitz M A; Beal M F
The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(2):144-8.
1999: Montine T J; Beal M F; Cudkowicz M E; O'Donnell H; Margolin R A; McFarland L; Bachrach A F; Zackert W E; Roberts L J; Morrow J D
Increased CSF F2-isoprostane concentration in probable AD.
Neurology 1999;52(3):562-5.
1999: Mecocci P; Fanó G; Fulle S; MacGarvey U; Shinobu L; Polidori M C; Cherubini A; Vecchiet J; Senin U; Beal M F
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle.
Free radical biology & medicine 1999;26(3-4):303-8.
1999: Ayoub I A; Lee E J; Ogilvy C S; Beal M F; Maynard K I
Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats.
Neuroscience letters 1999;259(1):21-4.
1999: Browne S E; Ferrante R J; Beal M F
Oxidative stress in Huntington's disease.
Brain pathology (Zurich, Switzerland) 1999;9(1):147-63.
1999: Beal M F
Mitochondria, NO and neurodegeneration.
Biochemical Society symposium 1999;66():43-54.
1999: Jenkins B G; Chen Y I; Kuestermann E; Makris N M; Nguyen T V; Kraft E; Brownell A L; Rosas H D; Kennedy D N; Rosen B R; Koroshetz W J; Beal M F
An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques.
Annals of the New York Academy of Sciences 1999;893():214-42.
1999: Grünewald T; Beal M F
Bioenergetics in Huntington's disease.
Annals of the New York Academy of Sciences 1999;893():203-13.
1999: Fink K B; Andrews L J; Butler W E; Ona V O; Li M; Bogdanov M; Endres M; Khan S Q; Namura S; Stieg P E; Beal M F; Moskowitz M A; Yuan J; Friedlander R M
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.
Neuroscience 1999;94(4):1213-8.
1999: Shults C W; Haas R H; Beal M F
A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease.
BioFactors (Oxford, England) 1999;9(2-4):267-72.
1999: Beal M F
Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases.
BioFactors (Oxford, England) 1999;9(2-4):261-6.
1999: Facchinetti F; Sasaki M; Cutting F B; Zhai P; MacDonald J E; Reif D; Beal M F; Huang P L; Dawson T M; Gurney M E; Dawson V L
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
Neuroscience 1999;90(4):1483-92.
1999: Acworth I N; Bogdanov M B; McCabe D R; Beal M F
Estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection.
Methods in enzymology 1999;300():297-313.
1998: Bogdanov M B; Ferrante R J; Kuemmerle S; Klivenyi P; Beal M F
Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease.
Journal of neurochemistry 1998;71(6):2642-4.
1998: Klivenyi P; Beal M F; Ferrante R J; Andreassen O A; Wermer M; Chin M R; Bonventre J V
Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity.
Journal of neurochemistry 1998;71(6):2634-7.
1998: Andreassen O A; Ferrante R J; Beal M F; Jørgensen H A
Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid.
Neuroscience 1998;87(3):639-48.
1998: Disatnik M H; Dhawan J; Yu Y; Beal M F; Whirl M M; Franco A A; Rando T A
Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state.
Journal of the neurological sciences 1998;161(1):77-84.
1998: Schulz J B; Weller M; Matthews R T; Heneka M T; Groscurth P; Martinou J C; Lommatzsch J; von Coelln R; Wüllner U; Löschmann P A; Beal M F; Dichgans J; Klockgether T
Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia.
Cell death and differentiation 1998;5(10):847-57.
1998: Yang L; Matthews R T; Schulz J B; Klockgether T; Liao A W; Martinou J C; Penney J B; Hyman B T; Beal M F
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8145-52.
1998: Beal M F
Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis.
Annals of neurology 1998;44(3 Suppl 1):S110-4.
1998: Polidori M C; Frei B; Cherubini A; Nelles G; Rordorf G; Keaney J F; Schwamm L; Mecocci P; Koroshetz W J; Beal M F
Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke.
Free radical biology & medicine 1998;25(4-5):561-7.
1998: Bogdanov M B; Ramos L E; Xu Z; Beal M F
Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.
Journal of neurochemistry 1998;71(3):1321-4.
1998: Beal M F
Mitochondrial dysfunction in neurodegenerative diseases.
Biochimica et biophysica acta 1998;1366(1-2):211-23.
1998: Klivenyi P; Matthews R T; Wermer M; Yang L; MacGarvey U; Becker D A; Natero R; Beal M F
Azulenyl nitrone spin traps protect against MPTP neurotoxicity.
Experimental neurology 1998;152(1):163-6.
1998: Matthews R T; Yang L; Browne S; Baik M; Beal M F
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8892-7.
1998: Browne S E; Bowling A C; Baik M J; Gurney M; Brown R H; Beal M F
Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis.
Journal of neurochemistry 1998;71(1):281-7.
1998: Smith M A; Sayre L M; Anderson V E; Harris P L; Beal M F; Kowall N; Perry G
Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(6):731-5.
1998: Jenkins B G; Rosas H D; Chen Y C; Makabe T; Myers R; MacDonald M; Rosen B R; Beal M F; Koroshetz W J
1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers.
Neurology 1998;50(5):1357-65.
1998: McKee A C; Kowall N W; Schumacher J S; Beal M F
The neurotoxicity of amyloid beta protein in aged primates.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(1):1-9.
1998: Shults C W; Beal M F; Fontaine D; Nakano K; Haas R H
Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients.
Neurology 1998;50(3):793-5.
1998: Beal M F; Matthews R T; Tieleman A; Shults C W
Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.
Brain research 1998;783(1):109-14.
1998: Matthews R T; Yang L; Jenkins B G; Ferrante R J; Rosen B R; Kaddurah-Daouk R; Beal M F
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):156-63.
1998: Lancelot E; Beal M F
Glutamate toxicity in chronic neurodegenerative disease.
Progress in brain research 1998;116():331-47.
1997: Ferrante R J; Browne S E; Shinobu L A; Bowling A C; Baik M J; MacGarvey U; Kowall N W; Brown R H; Beal M F
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.
Journal of neurochemistry 1997;69(5):2064-74.
1997: Beal M F; Ferrante R J; Browne S E; Matthews R T; Kowall N W; Brown R H
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.
Annals of neurology 1997;42(4):644-54.
1997: Beal M F
New techniques for investigating mitochondrial DNA in neurodegenerative diseases.
Neurology 1997;49(4):907-8.
1997: Chen Y C; Galpern W R; Brownell A L; Matthews R T; Bogdanov M; Isacson O; Keltner J R; Beal M F; Rosen B R; Jenkins B G
Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997;38(3):389-98.
1997: Schulz J B; Matthews R T; Klockgether T; Dichgans J; Beal M F
The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases.
Molecular and cellular biochemistry 1997;174(1-2):193-7.
1997: Ferrante R J; Shinobu L A; Schulz J B; Matthews R T; Thomas C E; Kowall N W; Gurney M E; Beal M F
Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.
Annals of neurology 1997;42(3):326-34.
1997: Ayata C; Ayata G; Hara H; Matthews R T; Beal M F; Ferrante R J; Endres M; Kim A; Christie R H; Waeber C; Huang P L; Hyman B T; Moskowitz M A
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6908-17.
1997: Shults C W; Haas R H; Passov D; Beal M F
Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.
Annals of neurology 1997;42(2):261-4.
1997: Bruijn L I; Beal M F; Becher M W; Schulz J B; Wong P C; Price D L; Cleveland D W
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7606-11.
1997: Matthews R T; Ferrante R J; Jenkins B G; Browne S E; Goetz K; Berger S; Chen I Y; Beal M F
Iodoacetate produces striatal excitotoxic lesions.
Journal of neurochemistry 1997;69(1):285-9.
1997: Mecocci P; Beal M F; Cecchetti R; Polidori M C; Cherubini A; Chionne F; Avellini L; Romano G; Senin U
Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;31(1):53-64.
1997: Browne S E; Bowling A C; MacGarvey U; Baik M J; Berger S C; Muqit M M; Bird E D; Beal M F
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.
Annals of neurology 1997;41(5):646-53.
1997: Ferrante R J; Gutekunst C A; Persichetti F; McNeil S M; Kowall N W; Gusella J F; MacDonald M E; Beal M F; Hersch S M
Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(9):3052-63.
1997: Schulz J B; Panahian N; Chen Y I; Beal M F; Moskowitz M A; Rosen B R; Jenkins B G
Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques.
The American journal of physiology 1997;272(4 Pt 2):H1986-95.
1997: Ferrante R J; Schulz J B; Kowall N W; Beal M F
Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra.
Brain research 1997;753(1):157-62.
1997: Mazurek M F; Garside S; Beal M F
Cortical peptide changes in Huntington's disease may be independent of striatal degeneration.
Annals of neurology 1997;41(4):540-7.
1997: Davis R E; Miller S; Herrnstadt C; Ghosh S S; Fahy E; Shinobu L A; Galasko D; Thal L J; Beal M F; Howell N; Parker W D
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4526-31.
1997: Fallon J; Matthews R T; Hyman B T; Beal M F
MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Experimental neurology 1997;144(1):193-8.
1997: Matthews R T; Yang L; Beal M F
S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity.
Experimental neurology 1997;143(2):282-6.
1997: Koroshetz W J; Jenkins B G; Rosen B R; Beal M F
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.
Annals of neurology 1997;41(2):160-5.
1997: Matthews R T; Beal M F; Fallon J; Fedorchak K; Huang P L; Fishman M C; Hyman B T
MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice.
Neurobiology of disease 1997;4(2):114-21.
1997: Polidori M C; Frei B; Rordorf G; Ogilvy C S; Koroshetz W J; Beal M F
Increased levels of plasma cholesteryl ester hydroperoxides in patients with subarachnoid hemorrhage.
Free radical biology & medicine 1997;23(5):762-7.
1997: Beal M F; Matthews R T
Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases.
Molecular aspects of medicine 1997;18 Suppl():S169-79.
1996: Galpern W R; Matthews R T; Beal M F; Isacson O
NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.
Neuroreport 1996;7(15-17):2639-42.
1996: Beal M F
Mitochondria, free radicals, and neurodegeneration.
Current opinion in neurobiology 1996;6(5):661-6.
1996: Hantraye P; Brouillet E; Ferrante R; Palfi S; Dolan R; Matthews R T; Beal M F
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.
Nature medicine 1996;2(9):1017-21.
1996: Schulz J B; Henshaw D R; MacGarvey U; Beal M F
Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity.
Neurochemistry international 1996;29(2):167-71.
1996: Smith M A; Perry G; Richey P L; Sayre L M; Anderson V E; Beal M F; Kowall N
Oxidative damage in Alzheimer's.
Nature 1996;382(6587):120-1.
1996: Schulz J B; Huang P L; Matthews R T; Passov D; Fishman M C; Beal M F
Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.
Journal of neurochemistry 1996;67(1):430-3.
1996: Vécsei L; Beal M F
Huntington's disease, behavioral disturbances, and kynurenines: preclinical findings and therapeutic perspectives.
Biological psychiatry 1996;39(12):1061-3.
1996: Reaume A G; Elliott J L; Hoffman E K; Kowall N W; Ferrante R J; Siwek D F; Wilcox H M; Flood D G; Beal M F; Brown R H; Scott R W; Snider W D
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Nature genetics 1996;13(1):43-7.
1996: Palfi S; Ferrante R J; Brouillet E; Beal M F; Dolan R; Guyot M C; Peschanski M; Hantraye P
Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(9):3019-25.
1996: Jenkins B G; Brouillet E; Chen Y C; Storey E; Schulz J B; Kirschner P; Beal M F; Rosen B R
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(3):450-61.
1996: Matthews R T; Beal M F
Increased 3-nitrotyrosine in brains of Apo E-deficient mice.
Brain research 1996;718(1-2):181-4.
1996: Schulz J B; Matthews R T; Henshaw D R; Beal M F
Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases.
Neuroscience 1996;71(4):1043-8.
1996: Mecocci P; Cherubini A; Beal M F; Cecchetti R; Chionne F; Polidori M C; Romano G; Senin U
Altered mitochondrial membrane fluidity in AD brain.
Neuroscience letters 1996;207(2):129-32.
1996: Kirschner P B; Jenkins B G; Schulz J B; Finkelstein S P; Matthews R T; Rosen B R; Beal M F
NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals.
Brain research 1996;713(1-2):178-85.
1996: Galpern W R; Frim D M; Tatter S B; Altar C A; Beal M F; Isacson O
Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration.
Cell transplantation 1996;5(2):225-32.
1996: Olanow C W; Good P F; Shinotoh H; Hewitt K A; Vingerhoets F; Snow B J; Beal M F; Calne D B; Perl D P
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study.
Neurology 1996;46(2):492-8.
1995: Schulz J B; Matthews R T; Beal M F
Role of nitric oxide in neurodegenerative diseases.
Current opinion in neurology 1995;8(6):480-6.
1995: Beal M F
Metabolic disorders and neurotoxicology.
Current opinion in neurology 1995;8(6):467-8.
1995: Goff D C; Tsai G; Beal M F; Coyle J T
Tardive dyskinesia and substrates of energy metabolism in CSF.
The American journal of psychiatry 1995;152(12):1730-6.
1995: Schulz J B; Matthews R T; Jenkins B G; Brar P; Beal M F
Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(6):948-52.
1995: Aronin N; Chase K; Young C; Sapp E; Schwarz C; Matta N; Kornreich R; Landwehrmeyer B; Bird E; Beal M F
CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Neuron 1995;15(5):1193-201.
1995: Horton T M; Graham B H; Corral-Debrinski M; Shoffner J M; Kaufman A E; Beal M F; Wallace D C
Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients.
Neurology 1995;45(10):1879-83.
1995: Dawson R; Beal M F; Bondy S C; Di Monte D A; Isom G E
Excitotoxins, aging, and environmental neurotoxins: implications for understanding human neurodegenerative diseases.
Toxicology and applied pharmacology 1995;134(1):1-17.
1995: Beal M F
Aging, energy, and oxidative stress in neurodegenerative diseases.
Annals of neurology 1995;38(3):357-66.
1995: Schulz J B; Beal M F
Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease.
Annals of the New York Academy of Sciences 1995;765():100-10; discussion 116-8.
1995: Beal M F; Ferrante R J; Henshaw R; Matthews R T; Chan P H; Kowall N W; Epstein C J; Schulz J B
3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.
Journal of neurochemistry 1995;65(2):919-22.
1995: Kirschner P B; Henshaw R; Weise J; Trubetskoy V; Finklestein S; Schulz J B; Beal M F
Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(4):619-23.
1995: Brouillet E; Hantraye P; Ferrante R J; Dolan R; Leroy-Willig A; Kowall N W; Beal M F
Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7105-9.
1995: Bowling A C; Barkowski E E; McKenna-Yasek D; Sapp P; Horvitz H R; Beal M F; Brown R H
Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis.
Journal of neurochemistry 1995;64(5):2366-9.
1995: Schulz J B; Henshaw D R; Siwek D; Jenkins B G; Ferrante R J; Cipolloni P B; Kowall N W; Rosen B R; Beal M F
Involvement of free radicals in excitotoxicity in vivo.
Journal of neurochemistry 1995;64(5):2239-47.
1995: Schulz J B; Henshaw D R; Matthews R T; Beal M F
Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity.
Experimental neurology 1995;132(2):279-83.
1995: Schulz J B; Matthews R T; Muqit M M; Browne S E; Beal M F
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.
Journal of neurochemistry 1995;64(2):936-9.
1995: Bowling A C; Beal M F
Bioenergetic and oxidative stress in neurodegenerative diseases.
Life sciences 1995;56(14):1151-71.
1994: Beal M F; Henshaw D R; Jenkins B G; Rosen B R; Schulz J B
Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate.
Annals of neurology 1994;36(6):882-8.
1994: Mutisya E M; Bowling A C; Beal M F
Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.
Journal of neurochemistry 1994;63(6):2179-84.
1994: Beal M F
Neurochemistry and toxin models in Huntington's disease.
Current opinion in neurology 1994;7(6):542-7.
1994: Mecocci P; MacGarvey U; Beal M F
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease.
Annals of neurology 1994;36(5):747-51.
1994: Schulz J B; Henshaw D R; Jenkins B G; Ferrante R J; Kowall N W; Rosen B R; Beal M F
3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(6):1024-9.
1994: Browne S E; Beal M F
Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases.
Biochemical Society transactions 1994;22(4):1002-6.
1994: Wüllner U; Young A B; Penney J B; Beal M F
3-Nitropropionic acid toxicity in the striatum.
Journal of neurochemistry 1994;63(5):1772-81.
1994: Brouillet E; Hyman B T; Jenkins B G; Henshaw D R; Schulz J B; Sodhi P; Rosen B R; Beal M F
Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism.
Experimental neurology 1994;129(2):175-82.
1994: Corral-Debrinski M; Horton T; Lott M T; Shoffner J M; McKee A C; Beal M F; Graham B H; Wallace D C
Marked changes in mitochondrial DNA deletion levels in Alzheimer brains.
Genomics 1994;23(2):471-6.
1994: Andersen J K; Frim D M; Isacson O; Beal M F; Breakefield X O
Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Brain research 1994;656(1):108-14.
1994: Frim D M; Wüllner U; Beal M F; Isacson O
Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum.
Experimental neurology 1994;128(2):172-80.
1994: Schulz J B; Beal M F
Mitochondrial dysfunction in movement disorders.
Current opinion in neurology 1994;7(4):333-9.
1994: Brouillet E; Henshaw D R; Schulz J B; Beal M F
Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10.
Neuroscience letters 1994;177(1-2):58-62.
1994: Esteban J; Rosen D R; Bowling A C; Sapp P; McKenna-Yasek D; O'Regan J P; Beal M F; Horvitz H R; Brown R H
Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis.
Human molecular genetics 1994;3(6):997-8.
1994: Storey E; Cipolloni P B; Ferrante R J; Kowall N W; Beal M F
Movement disorder following excitotoxin lesions in primates.
Neuroreport 1994;5(10):1259-61.
1994: Frim D M; Uhler T A; Galpern W R; Beal M F; Breakefield X O; Isacson O
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5104-8.
1994: Henshaw R; Jenkins B G; Schulz J B; Ferrante R J; Kowall N W; Rosen B R; Beal M F
Malonate produces striatal lesions by indirect NMDA receptor activation.
Brain research 1994;647(1):161-6.
1994: Beal M F
Huntington's disease, energy, and excitotoxicity.
Neurobiology of aging 1994;15(2):275-6.
1994: Beal M F
Energy, oxidative damage, and Alzheimer's disease: clues to the underlying puzzle.
Neurobiology of aging 1994;15 Suppl 2():S171-4.
1993: Roberts R C; Ahn A; Swartz K J; Beal M F; DiFiglia M
Intrastriatal injections of quinolinic acid or kainic acid: differential patterns of cell survival and the effects of data analysis on outcome.
Experimental neurology 1993;124(2):274-82.
1993: Jenkins B G; Koroshetz W J; Beal M F; Rosen B R
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.
Neurology 1993;43(12):2689-95.
1993: Bowling A C; Schulz J B; Brown R H; Beal M F
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.
Journal of neurochemistry 1993;61(6):2322-5.
1993: Beal M F
Neurochemical aspects of aging in primates.
Neurobiology of aging 1993;14(6):707-9.
1993: Mecocci P; MacGarvey U; Kaufman A E; Koontz D; Shoffner J M; Wallace D C; Beal M F
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.
Annals of neurology 1993;34(4):609-16.
1993: Storey E; Beal M F
Neurochemical substrates of rigidity and chorea in Huntington's disease.
Brain : a journal of neurology 1993;116 ( Pt 5)():1201-22.
1993: Beal M F; Brouillet E; Jenkins B G; Ferrante R J; Kowall N W; Miller J M; Storey E; Srivastava R; Rosen B R; Hyman B T
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4181-92.
1993: Beal M F; Brouillet E; Jenkins B; Henshaw R; Rosen B; Hyman B T
Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate.
Journal of neurochemistry 1993;61(3):1147-50.
1993: Shoffner J M; Brown M D; Torroni A; Lott M T; Cabell M F; Mirra S S; Beal M F; Yang C C; Gearing M; Salvo R
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.
Genomics 1993;17(1):171-84.
1993: Srivastava R; Brouillet E; Beal M F; Storey E; Hyman B T
Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.
Neurobiology of aging 1993;14(4):295-301.
1993: Bowling A C; Mutisya E M; Walker L C; Price D L; Cork L C; Beal M F
Age-dependent impairment of mitochondrial function in primate brain.
Journal of neurochemistry 1993;60(5):1964-7.
1993: Brouillet E; Beal M F
NMDA antagonists partially protect against MPTP induced neurotoxicity in mice.
Neuroreport 1993;4(4):387-90.
1993: Beal M F; Hyman B T; Koroshetz W
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
Trends in neurosciences 1993;16(4):125-31.
1993: Brouillet E P; Shinobu L; McGarvey U; Hochberg F; Beal M F
Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism.
Experimental neurology 1993;120(1):89-94.
1993: Nozaki K; Finklestein S P; Beal M F
Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.
European journal of pharmacology 1993;232(2-3):295-7.
1993: Nozaki K; Finklestein S P; Beal M F
Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(2):221-8.
1993: Ferrante R J; Kowall N W; Cipolloni P B; Storey E; Beal M F
Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization.
Experimental neurology 1993;119(1):46-71.
1993: Brouillet E; Jenkins B G; Hyman B T; Ferrante R J; Kowall N W; Srivastava R; Roy D S; Rosen B R; Beal M F
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Journal of neurochemistry 1993;60(1):356-9.
1992: Beal M F
Mechanisms of excitotoxicity in neurologic diseases.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(15):3338-44.
1992: Corral-Debrinski M; Horton T; Lott M T; Shoffner J M; Beal M F; Wallace D C
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.
Nature genetics 1992;2(4):324-9.
1992: Miller J M; MacGarvey U; Beal M F
The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations.
Neuroscience letters 1992;146(1):115-8.
1992: Beal M F
Role of excitotoxicity in human neurological disease.
Current opinion in neurobiology 1992;2(5):657-62.
1992: Storey E; Kowall N W; Finn S F; Mazurek M F; Beal M F
The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Annals of neurology 1992;32(4):526-34.
1992: Ogawa T; Matson W R; Beal M F; Myers R H; Bird E D; Milbury P; Saso S
Kynurenine pathway abnormalities in Parkinson's disease.
Neurology 1992;42(9):1702-6.
1992: Kowall N W; McKee A C; Yankner B A; Beal M F
In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.
Neurobiology of aging 1992;13(5):537-42.
1992: Vécsei L; Beal M F
Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats.
European journal of pharmacology 1992;220(2-3):259-62.
1992: Beal M F; Swartz K J; Isacson O
Developmental changes in brain kynurenic acid concentrations.
Brain research. Developmental brain research 1992;68(1):136-9.
1992: Nozaki K; Beal M F
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(3):400-7.
1992: Storey E; Hyman B T; Jenkins B; Brouillet E; Miller J M; Rosen B R; Beal M F
1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.
Journal of neurochemistry 1992;58(5):1975-8.
1992: Martin J B; Beal M F
Huntington's disease and neurotoxins.
Annals of the New York Academy of Sciences 1992;648():169-75.
1992: Beal M F; Matson W R; Storey E; Milbury P; Ryan E A; Ogawa T; Bird E D
Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex.
Journal of the neurological sciences 1992;108(1):80-7.
1992: Vécsei L; Miller J; MacGarvey U; Beal M F
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Brain research bulletin 1992;28(2):233-8.
1992: Beal M F
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
Annals of neurology 1992;31(2):119-30.
1991: Uemura Y; Miller J M; Matson W R; Beal M F
Neurochemical analysis of focal ischemia in rats.
Stroke; a journal of cerebral circulation 1991;22(12):1548-53.
1991: Finn S F; Hyman B T; Storey E; Miller J M; Beal M F
Effects of aging on quinolinic acid lesions in rat striatum.
Brain research 1991;562(2):276-80.
1991: Beal M F; Swartz K J; Hyman B T; Storey E; Finn S F; Koroshetz W
Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Journal of neurochemistry 1991;57(3):1068-73.
1991: Beal M F; Walker L C; Storey E; Segar L; Price D L; Cork L C
Neurotransmitters in neocortex of aged rhesus monkeys.
Neurobiology of aging 1991;12(5):407-12.
1991: Kowall N W; Beal M F; Busciglio J; Duffy L K; Yankner B A
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7247-51.
1991: Vécsei L; Beal M F
Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.
Pharmacology, biochemistry, and behavior 1991;39(2):473-8.
1991: Beal M F; Ferrante R J; Swartz K J; Kowall N W
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(6):1649-59.
1991: Finn S F; Swartz K J; Beal M F
2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity.
Neuroscience letters 1991;126(2):191-4.
1991: Mazurek M F; Beal M F
Cholecystokinin and somatostatin in Alzheimer's disease postmortem cerebral cortex.
Neurology 1991;41(5):716-9.
1991: Vécsei L; Beal M F
Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats.
European journal of pharmacology 1991;196(3):239-46.
1991: Uemura Y; Kowall N W; Beal M F
Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus.
Brain research 1991;542(2):343-7.
1991: Kowall N W; Beal M F
Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease.
Annals of neurology 1991;29(2):162-7.
1991: Heyes M P; Swartz K J; Markey S P; Beal M F
Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease.
Neuroscience letters 1991;122(2):265-9.
1991: Beal M F; Swartz K J; Finn S F; Mazurek M F; Kowall N W
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(1):147-58.
1990: Vécsei L; Beal M F
Intracerebroventricular injection of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behavior in rats.
Brain research bulletin 1990;25(4):623-7.
1990: Beal M F; Matson W R; Swartz K J; Gamache P H; Bird E D
Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid.
Journal of neurochemistry 1990;55(4):1327-39.
1990: Vécsei L; Beal M F
Influence of kynurenine treatment on open-field activity, elevated plus-maze, avoidance behaviors and seizures in rats.
Pharmacology, biochemistry, and behavior 1990;37(1):71-6.
1990: Swartz K J; During M J; Freese A; Beal M F
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(9):2965-73.
1990: Beal M F
Somatostatin in neurodegenerative illnesses.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):116-9.
1990: Beal M F; MacGarvey U; Swartz K J
Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease.
Annals of neurology 1990;28(2):157-61.
1990: Freese A; DiFiglia M; Koroshetz W J; Beal M F; Martin J B
Characterization and mechanism of glutamate neurotoxicity in primary striatal cultures.
Brain research 1990;521(1-2):254-64.
1990: Uemura Y; Kowall N W; Beal M F
Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum.
Annals of neurology 1990;27(6):620-5.
1990: Swartz K J; Matson W R; MacGarvey U; Ryan E A; Beal M F
Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection.
Analytical biochemistry 1990;185(2):363-76.
1990: Beal M F
Multiple cranial-nerve palsies: a diagnostic challenge.
The New England journal of medicine 1990;322(7):461-3.
1990: Beal M F; Kowall N W; Swartz K J; Ferrante R J
Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons.
Neuroscience letters 1990;108(1-2):36-42.
1989: Pitkänen A; Beal M F; Sirviö J; Swartz K J; Männistö P T; Riekkinen P J
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Neuropeptides 1989;14(3):197-207.
1989: Clevens R A; Beal M F
Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases.
Brain research 1989;486(2):387-90.
1989: Kowall N W; Beal M F
Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease.
Neuroscience letters 1989;98(1):118-23.
1989: Kowall N W; Pendlebury W W; Kessler J B; Perl D P; Beal M F
Aluminum-induced neurofibrillary degeneration affects a subset of neurons in rabbit cerebral cortex, basal forebrain and upper brainstem.
Neuroscience 1989;29(2):329-37.
1989: Beal M F; Mazurek M F; Ellison D W; Kowall N W; Solomon P R; Pendlebury W W
Neurochemical characteristics of aluminum-induced neurofibrillary degeneration in rabbits.
Neuroscience 1989;29(2):339-46.
1989: Beal M F; Kowall N W; Swartz K J; Ferrante R J; Martin J B
Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Synapse (New York, N.Y.) 1989;3(1):38-47.
1988: Beal M F
Cerebral aspergillosis.
New York state journal of medicine 1988;88(12):620-2.
1988: Beal M F; Clevens R A; Chattha G K; MacGarvey U M; Mazurek M F; Gabriel S M
Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex.
Journal of neurochemistry 1988;51(6):1935-41.
1988: Beal M F; Walker L C; Swartz K J; Casanova M F; Price D L
Developmental changes of neuropeptides and amino acids in baboon cortex.
Brain research. Developmental brain research 1988;44(1):156-9.
1988: Kaye J A; May C; Atack J R; Daly E; Sweeney D L; Beal M F; Kaufman S; Milstien S; Friedland R P; Rapoport S I
Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease.
Annals of neurology 1988;24(5):647-50.
1988: Beal M F; Kowall N W; Swartz K J; Ferrante R J; Martin J B
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(10):3901-8.
1988: Solomon P R; Beal M F; Pendlebury W W
Age-related disruption of classical conditioning: a model systems approach to memory disorders.
Neurobiology of aging 1988;9(5-6):535-46.
1988: Beal M F; Gabriel S M; Swartz K J; MacGarvey U M
Distribution of galanin-like immunoreactivity in baboon brain.
Peptides 1988;9(4):847-51.
1988: Beal M F; Mazurek M F; Ellison D W; Swartz K J; McGarvey U; Bird E D; Martin J B
Somatostatin and neuropeptide Y concentrations in pathologically graded cases of Huntington's disease.
Annals of neurology 1988;23(6):562-9.
1988: Beal M F; Swartz K J; Finn S F; Bird E D; Martin J B
Amino acid and neuropeptide neurotransmitters in Huntington's disease cerebellum.
Brain research 1988;454(1-2):393-6.
1988: Gabriel S M; MacGarvey U M; Koenig J I; Swartz K J; Martin J B; Beal M F
Characterization of galanin-like immunoreactivity in the rat brain: effects of neonatal glutamate treatment.
Neuroscience letters 1988;87(1-2):114-21.
1988: Atack J R; Beal M F; May C; Kaye J A; Mazurek M F; Kay A D; Rapoport S I
Cerebrospinal fluid somatostatin and neuropeptide Y. Concentrations in aging and in dementia of the Alzheimer type with and without extrapyramidal signs.
Archives of neurology 1988;45(3):269-74.
1988: Beal M F; Ellison D W; Mazurek M F; Swartz K J; Malloy J R; Bird E D; Martin J B
A detailed examination of substance P in pathologically graded cases of Huntington's disease.
Journal of the neurological sciences 1988;84(1):51-61.
1988: Kowall N W; Beal M F
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
Annals of neurology 1988;23(2):105-14.
1988: Pendlebury W W; Beal M F; Kowall N W; Solomon P R
Neuropathologic, neurochemical and immunocytochemical characteristics of aluminum-induced neurofilamentous degeneration.
Neurotoxicology 1988;9(3):503-10.
1988: Beal M F; Clevens R A; Mazurek M F
Somatostatin and neuropeptide Y immunoreactivity in Parkinson's disease dementia with Alzheimer's changes.
Synapse (New York, N.Y.) 1988;2(4):463-7.
1987: Ellison D W; Beal M F; Mazurek M F; Malloy J R; Bird E D; Martin J B
Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease.
Brain : a journal of neurology 1987;110 ( Pt 6)():1657-73.
1987: Ellison D W; Beal M F; Martin J B
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease.
Brain research 1987;417(2):389-92.
1987: Beal M F; Mazurek M F; McKee M A
The regional distribution of somatostatin and neuropeptide Y in control and Alzheimer's disease striatum.
Neuroscience letters 1987;79(1-2):201-6.
1987: Matson W R; Gamache P G; Beal M F; Bird E D
EC array sensor concepts and data.
Life sciences 1987;41(7):905-8.
1987: Beal M F; Mazurek M F
Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex.
Neurology 1987;37(7):1205-9.
1987: Mazurek M F; Beal M F; Bird E D; Martin J B
Oxytocin in Alzheimer's disease: postmortem brain levels.
Neurology 1987;37(6):1001-3.
1987: Beal M F; Svendsen C N; Bird E D; Martin J B
Somatostatin and neuropeptide Y are unaltered in the amygdala in schizophrenia.
Neurochemical pathology 1987;6(3):169-76.
1987: Ferrante R J; Beal M F; Kowall N W; Richardson E P; Martin J B
Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease.
Brain research 1987;411(1):162-6.
1987: Tatsuoka Y; Riskind P N; Beal M F; Martin J B
The effect of amphetamine on the in vivo release of dopamine, somatostatin and neuropeptide Y from rat caudate nucleus.
Brain research 1987;411(1):200-3.
1987: Ellison D W; Beal M F; Martin J B
Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection.
Journal of neuroscience methods 1987;19(4):305-15.
1987: Beal M F; Mazurek M F; Martin J B
A comparison of somatostatin and neuropeptide Y distribution in monkey brain.
Brain research 1987;405(2):213-9.
1987: Kowall N W; Ferrante R J; Beal M F; Richardson E P; Sofroniew M V; Cuello A C; Martin J B
Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: a combined immunocytochemical and enzyme histochemical study.
Neuroscience 1987;20(3):817-28.
1987: Juncos J L; Beal M F
Idiopathic cranial polyneuropathy. A fifteen-year experience.
Brain : a journal of neurology 1987;110 ( Pt 1)():197-211.
1987: Chattha G K; Beal M F
Effect of cysteamine on somatostatin and neuropeptide Y in rat striatum and cortical synaptosomes.
Brain research 1987;401(2):359-64.
1987: Ferrante R J; Kowall N W; Beal M F; Martin J B; Bird E D; Richardson E P
Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease.
Journal of neuropathology and experimental neurology 1987;46(1):12-27.
1987: Pendlebury W W; Beal M F; Kowall N W; Solomon P R
Results of immunocytochemical, neurochemical, and behavioral studies in aluminum-induced neurofilamentous degeneration.
Journal of neural transmission. Supplementum 1987;24():213-7.
1987: Beal M F; Kowall N W; Mazurek M F
Neuropeptides in Alzheimer's disease.
Journal of neural transmission. Supplementum 1987;24():163-74.
1986: Mazurek M F; Beal M F; Bird E D; Martin J B
Vasopressin in Alzheimer's disease: a study of postmortem brain concentrations.
Annals of neurology 1986;20(6):665-70.
1986: Beal M F; Mazurek M F; Martin J B
Somatostatin immunoreactivity is reduced in Parkinson's disease dementia with Alzheimer's changes.
Brain research 1986;397(2):386-8.
1986: Mazurek M F; Beal M F; Martin J B
Neuropeptides in Alzheimer's disease. Clinical implications.
Neurologic clinics 1986;4(4):753-68.
1986: Beal M F; Martin J B
Neuropeptides in neurological disease.
Annals of neurology 1986;20(5):547-65.
1986: Ellison D W; Beal M F; Mazurek M F; Bird E D; Martin J B
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
Annals of neurology 1986;20(5):616-21.
1986: Beal M F; Mazurek M F; Svendsen C N; Bird E D; Martin J B
Widespread reduction of somatostatin-like immunoreactivity in the cerebral cortex in Alzheimer's disease.
Annals of neurology 1986;20(4):489-95.
1986: Beal M F; Frank R C; Ellison D W; Martin J B
The effect of neuropeptide Y on striatal catecholamines.
Neuroscience letters 1986;71(1):118-23.
1986: Beal M F; Mazurek M F; Chattha G K; Svendsen C N; Bird E D; Martin J B
Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease.
Annals of neurology 1986;20(3):282-8.
1986: Black P M; Ballantine H T; Carr D B; Beal M F; Martin J B
Beta-endorphin and somatostatin concentrations in the ventricular cerebrospinal fluid of patients with affective disorder.
Biological psychiatry 1986;21(11):1077-81.
1986: Mazurek M F; Growdon J H; Beal M F; Martin J B
CSF vasopressin concentration is reduced in Alzheimer's disease.
Neurology 1986;36(8):1133-7.
1986: Beal M F; Chattha G K; Martin J B
A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain.
Brain research 1986;377(2):240-5.
1986: Mair R G; Langlais P J; Mazurek M F; Beal M F; Martin J B; McEntee W J
Reduced concentrations of arginine vasopressin and MHPG in lumbar CSF of patients with Korsakoff's psychosis.
Life sciences 1986;38(25):2301-6.
1986: Beal M F; Kowall N W; Ellison D W; Mazurek M F; Swartz K J; Martin J B
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid.
Nature 1986;321(6066):168-71.
1986: Beal M F; Benoit R; Mazurek M F; Bird E D; Martin J B
Somatostatin-28(1-12)-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex.
Brain research 1986;368(2):380-3.
1986: Beal M F; Mazurek M F; Lorenz L J; Chattha G K; Ellison D W; Martin J B
An examination of neuropeptide Y postmortem stability in an animal model simulating human autopsy conditions.
Neuroscience letters 1986;64(1):69-74.
1986: Beal M F; Growdon J H; Mazurek M F; Martin J B
CSF somatostatin-like immunoreactivity in dementia.
Neurology 1986;36(2):294-7.
1986: Beal M F; Tran V T; Mazurek M F; Chattha G; Martin J B
Somatostatin binding sites in human and monkey brain: localization and characterization.
Journal of neurochemistry 1986;46(2):359-65.
1986: Volicer L; Beal M F; Direnfeld L K; Marquis J K; Albert M L
CSF cyclic nucleotides and somatostatin in Parkinson's disease.
Neurology 1986;36(1):89-92.
1986: Beal M F; Growdon J H
CSF neurotransmitter markers in Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry 1986;10(3-5):259-70.
1986: Beal M F; Uhl G; Mazurek M F; Kowall N; Martin J B
Somatostatin: alterations in the central nervous system in neurological diseases.
Research publications - Association for Research in Nervous and Mental Disease 1986;64():215-57.
1985: Beal M F; Marshall P E; Burd G D; Landis D M; Martin J B
Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.
Brain research 1985;361(1-2):135-45.
1985: Beal M F; Martin J B
Topographical dopamine and serotonin distribution and turnover in rat striatum.
Brain research 1985;358(1-2):10-5.
1985: Ferrante R J; Kowall N W; Beal M F; Richardson E P; Bird E D; Martin J B
Selective sparing of a class of striatal neurons in Huntington's disease.
Science (New York, N.Y.) 1985;230(4725):561-3.
1985: Beal M F; Mazurek M F; Black P M; Martin J B
Human cerebrospinal fluid somatostatin in neurologic disease.
Journal of the neurological sciences 1985;71(1):91-104.
1985: Kowall N W; Beal M F; Ferrante R J; Martin J B
Topography of nicotinamide adenine dinucleotide phosphate-diaphorase staining neurons in rat striatum.
Neuroscience letters 1985;59(1):61-6.
1985: Beal M F; Mazurek M F; Tran V T; Chattha G; Bird E D; Martin J B
Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease.
Science (New York, N.Y.) 1985;229(4710):289-91.
1985: Beal M F; Benoit R; Bird E D; Martin J B
Immunoreactive somatostatin-28(1-12) is increased in Huntington's disease.
Neuroscience letters 1985;56(3):377-80.
1985: Tran V T; Beal M F; Martin J B
Two types of somatostatin receptors differentiated by cyclic somatostatin analogs.
Science (New York, N.Y.) 1985;228(4698):492-5.
1985: Beal M F; Domesick V B; Martin J B
Effects of lesions in the amygdala and periventricular hypothalamus on striatal somatostatin-like immunoreactivity.
Brain research 1985;330(2):309-16.
1985: Beal M F; Fisher J; Carr D B; Martin J B
Effects of neuroleptic drugs on brain beta-endorphin immunoreactivity.
Neuroscience letters 1985;53(2):173-8.
1984: Beal M F; Martin J B
Depletion of striatal somatostatin by local cysteamine injection.
Brain research 1984;308(2):319-24.
1984: Beal M F; Martin J B
Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity.
Neuroscience letters 1984;47(2):125-30.
1984: Beal M F; Bird E D; Langlais P J; Martin J B
Somatostatin is increased in the nucleus accumbens in Huntington's disease.
Neurology 1984;34(5):663-6.
1984: Beal M F; Martin J B
The effect of somatostatin on striatal catecholamines.
Neuroscience letters 1984;44(3):271-6.
1984: Sagar S M; Beal M F; Marshall P E; Landis D M; Martin J B
Implications of neuropeptides in neurological diseases.
Peptides 1984;5 Suppl 1():255-62.
1983: Beal M F; Domesick V B; Martin J B
Regional somatostatin distribution in the rat striatum.
Brain research 1983;278(1-2):103-8.
1983: Hauser S L; Dawson D M; Lehrich J R; Beal M F; Kevy S V; Weiner H L
Immunosuppression and plasmapheresis in chronic progressive multiple sclerosis. Design of a clinical trial.
Archives of neurology 1983;40(11):687-90.
1983: Beal M F; Richardson E P; Brandstetter R; Hedley-Whyte E T; Hochberg F H
Localized brainstem ischemic damage and Ondine's curse after near-drowning.
Neurology 1983;33(6):717-21.
1983: Beal M F; Martin J B
Effects of lesions on somatostatin-like immunoreactivity in the rat striatum.
Brain research 1983;266(1):67-73.
1983: Hauser S L; Dawson D M; Lehrich J R; Beal M F; Kevy S V; Propper R D; Mills J A; Weiner H L
Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH.
The New England journal of medicine 1983;308(4):173-80.
1982: Beal M F
Amitriptyline ophthalmoplegia.
Neurology 1982;32(12):1409.
1982: Beal M F; Wechsler L R; Davis K R
Cerebral vein thrombosis and multiple intracranial hemorrhages by computed tomography.
Archives of neurology 1982;39(7):437-8.
1982: Beal M F; O'Carroll C P; Kleinman G M; Grossman R I
Aspergillosis of the nervous system.
Neurology 1982;32(5):473-9.
1982: Beal M F; Fisher C M
Neoplastic angioendotheliosis.
Journal of the neurological sciences 1982;53(2):359-75.
1981: Grossman R I; Davis K R; Taveras J M; Beal M F; O'Carroll C P
Computed tomography of intracranial aspergillosis.
Journal of computer assisted tomography 1981;5(5):646-50.
1981: Beal M F; Richardson E P
Primary lateral sclerosis: a case report.
Archives of neurology 1981;38(10):630-3.
1981: Beal M F; Kleinman G M; Ojemann R G; Hochberg F H
Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia.
Neurology 1981;31(10):1224-8.
1981: Beal M F; Williams R S; Richardson E P; Fisher C M
Cholesterol embolism as a cause of transient ischemic attacks and cerebral infarction.
Neurology 1981;31(7):860-5.
1981: Beal M F; Park T S; Fisher C M
Cerebral atheromatous embolism following carotid sinus pressure.
Archives of neurology 1981;38(5):310-2.
1980: Beal M F; Chapman P H
Cortical blindness and homonymous hemianopia in the postpartum period.
JAMA : the journal of the American Medical Association 1980;244(18):2085-7.
1977: Beal M F; Atuk N O; Westfall T C; Turner S M
Catecholamine uptake, accumulation, and release in acute porphyria.
The Journal of clinical investigation 1977;60(5):1141-8.

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