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Abner Mhashilkar
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Chemicals & Drugs
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Network (preview)
33
Chada, Sunil
21
Ramesh, Rajagopal
12
Grimm, Elizabeth
10
Roth, Jack
9
Marasco, Wayne
8
Ekmekcioglu, Suhendan
7
Branch, Cynthia
7
Mumm, John
7
Saito, Yuji
7
Sieger, Kerry
6
Zheng, Mingzhong
6
Gopalan, Began
5
Hunt, Kelly
5
Bocangel, Dora
5
Stewart, Alexis
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Geonetwork of Abner Mhashilkar (preview)
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All Publications
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2007: Zeng Lepeng; Hu Qingsong; Wang Xiaohong; Mansoor Abdul; Lee Joseph; Feygin Julia; Zhang Ge; Suntharalingam Piradeep; Boozer Sherry; Mhashilkar Abner; Panetta Carmelo J; Swingen Cory; Deans Robert; From Arthur H L; Bache Robert J; Verfaillie Catherine M; Zhang Jianyi
Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling.
Circulation 2007;115(14):1866-75.
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2007: Zheng Mingzhong; Bocangel Dora; Doneske Blair; Mhashilkar Abner; Ramesh Rajagopal; Hunt Kelly K; Ekmekcioglu Suhendan; Sutton R Bryan; Poindexter Nancy; Grimm Elizabeth A; Chada Sunil
Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10.
Cancer immunology, immunotherapy : CII 2007;56(2):205-15.
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2006: Bocangel D; Zheng M; Mhashilkar A; Liu Y; Ramesh R; Hunt K K; Chada S
Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells.
Cancer gene therapy 2006;13(10):958-68.
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2006: Chada S; Mhashilkar A M; Liu Y; Nishikawa T; Bocangel D; Zheng M; Vorburger S A; Pataer A; Swisher S G; Ramesh R; Kawase K; Meyn R E; Hunt K K
mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.
Cancer gene therapy 2006;13(5):490-502.
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2006: Inoue Satoshi; Shanker Manish; Miyahara Ryo; Gopalan Began; Patel Suraag; Oida Yasuhisa; Branch Cynthia D; Munshi Anupama; Meyn Raymond E; Andreeff Michael; Tanaka Fumihiro; Mhashilkar Abner M; Chada Sunil; Ramesh Rajagopal
MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic.
Current gene therapy 2006;6(1):73-91.
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2005: Khimani Anis H; Mhashilkar Abner M; Mikulskis Alvydas; O'Malley Michael; Liao Jennifer; Golenko Eva E; Mayer Pat; Chada Sunil; Killian Jeffrey B; Lott Steven T
Housekeeping genes in cancer: normalization of array data.
BioTechniques 2005;38(5):739-45.
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2005: Chada Sunil; Bocangel Dora; Ramesh Rajagopal; Grimm Elizabeth A; Mumm John B; Mhashilkar Abner M; Zheng Mingzhong
mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):724-33.
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2005: Gopalan Began; Litvak Anya; Sharma Sikha; Mhashilkar Abner M; Chada Sunil; Ramesh Rajagopal
Activation of the Fas-FasL signaling pathway by MDA-7/IL-24 kills human ovarian cancer cells.
Cancer research 2005;65(8):3017-24.
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2005: Saito Yuji; Miyahara Ryo; Gopalan Began; Litvak Anya; Inoue Satoshi; Shanker Manish; Branch Cynthia D; Mhashilkar Abner M; Roth Jack A; Chada Sunil; Ramesh Rajagopal
Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated -7 (mda-7)/interleukin-24 (IL-24) gene.
Cancer gene therapy 2005;12(3):238-47.
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2005: Oida Yasuhisa; Gopalan Began; Miyahara Ryo; Inoue Satoshi; Branch Cynthia D; Mhashilkar Abner M; Lin E; Bekele B Nebiyou; Roth Jack A; Chada Sunil; Ramesh Rajagopal
Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.
Molecular cancer therapeutics 2005;4(2):291-304.
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2005: Tong Alex W; Nemunaitis John; Su Dan; Zhang Yuan; Cunningham Casey; Senzer Neil; Netto George; Rich Dawn; Mhashilkar Abner; Parker Karen; Coffee Keith; Ramesh Rajagopal; Ekmekcioglu Suhendan; Grimm Elizabeth A; van Wart Hood Jill; Merritt James; Chada Sunil
Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):160-72.
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2005: Cunningham C Casey; Chada Sunil; Merritt James A; Tong Alex; Senzer Neil; Zhang Yuan; Mhashilkar Abner; Parker Karen; Vukelja Sasha; Richards Don; Hood Jill; Coffee Keith; Nemunaitis John
Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):149-59.
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2004: Chada Sunil; Mhashilkar Abner M; Ramesh Rajagopal; Mumm John B; Sutton R Bryan; Bocangel Dora; Zheng Mingzhong; Grimm Elizabeth A; Ekmekcioglu Suhendan
Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1085-95.
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2004: Aggarwal Sita; Takada Yasunari; Mhashilkar Abner M; Sieger Kerry; Chada Sunil; Aggarwal Bharat B
Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4368-76.
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2004: Beyer Florian; Doebis Cornelia; Busch Annette; Ritter Thomas; Mhashilkar Abner; Marasco Wayne M; Laube Horst; Volk Hans-Dieter; Seifert Martina
Decline of surface MHC I by adenoviral gene transfer of anti-MHC I intrabodies in human endothelial cells-new perspectives for the generation of universal donor cells for tissue transplantation.
The journal of gene medicine 2004;6(6):616-23.
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2004: Chada Sunil; Sutton R Bryan; Ekmekcioglu Suhendan; Ellerhorst Julie; Mumm John B; Leitner Wolfgang W; Yang Heng-Yin; Sahin Aysegul A; Hunt Kelly K; Fuson Kerry L; Poìndexter Nancy; Roth Jack A; Ramesh Rajagopal; Grimm Elizabeth A; Mhashilkar Abner M
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
International immunopharmacology 2004;4(5):649-67.
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2004: Ramesh Rajagopal; Ito Isao; Gopalan Began; Saito Yuji; Mhashilkar Abner M; Chada Sunil
Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(4):510-8.
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2004: Sieger Kerry A; Mhashilkar Abner M; Stewart Alexis; Sutton R Bryan; Strube Randall W; Chen Si Yi; Pataer Abujiang; Swisher Stephen G; Grimm Elizabeth A; Ramesh Rajagopal; Chada Sunil
The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(3):355-67.
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2003: Saito Yuji; Gopalan Began; Mhashilkar Abner M; Roth Jack A; Chada Sunil; Zumstein Louis; Ramesh Rajagopal
Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells.
Cancer gene therapy 2003;10(11):803-13.
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2003: Saito Y; Swanson X; Mhashilkar A M; Oida Y; Schrock R; Branch C D; Chada S; Zumstein L; Ramesh R
Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo.
Gene therapy 2003;10(23):1961-9.
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2003: Chada Sunil; Ramesh Rajagopal; Mhashilkar Abner M
Cytokine- and chemokine-based gene therapy for cancer.
Current opinion in molecular therapeutics 2003;5(5):463-74.
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2003: Ramesh Rajagopal; Mhashilkar Abner M; Tanaka Fumihiro; Saito Yuji; Branch Cynthia D; Sieger Kerry; Mumm John B; Stewart Alexis L; Boquoi Amelie; Dumoutier Laure; Grimm Elizabeth A; Renauld Jean-Christophe; Kotenko Sergei; Chada Sunil;
Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.
Cancer research 2003;63(16):5105-13.
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2003: Chen Jiyuan; Chada Sunil; Mhashilkar Abner; Miano Joseph M
Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):220-9.
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2003: Mhashilkar Abner M; Stewart Alexis L; Sieger Kerry; Yang Heng-Yin; Khimani Anis H; Ito Isao; Saito Yuji; Hunt Kelly K; Grimm Elizabeth A; Roth Jack A; Meyn Raymond E; Ramesh Rajagopal; Chada Sunil
MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):207-19.
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2003: Chada Sunil; Mhashilkar Abner; Roth Jack A; Gabrilovich Dmitry
Development of vaccines against self-antigens: the p53 paradigm.
Current opinion in drug discovery & development 2003;6(2):169-73.
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2003: Ekmekcioglu Suhendan; Ellerhorst Julie A; Mumm John B; Zheng Mingzhong; Broemeling Lyle; Prieto Victor G; Stewart Alexis L; Mhashilkar Abner M; Chada Sunil; Grimm Elizabeth A
Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells.
Molecular cancer therapeutics 2003;2(1):9-17.
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2002: Cao Xiaobo X; Mohuiddin Imran; Chada Sunil; Mhashilkar Abner M; Ozvaran Mustafa K; McConkey David J; Miller Steven D; Daniel Jonathon C; Smythe W Roy
Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL.
Molecular medicine (Cambridge, Mass.) 2002;8(12):869-76.
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2002: Stewart Alexis L; Mhashilkar Abner M; Yang Xiaohong Helena; Ekmekcioglu Suhendan; Saito Yuji; Sieger Kerry; Schrock Robert; Onishi Eric; Swanson Xin; Mumm John B; Zumstein Lou; Watson Graham J; Snary David; Roth Jack A; Grimm Elizabeth A; Ramesh Rajagopal; Chada Sunil
PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.
Molecular medicine (Cambridge, Mass.) 2002;8(8):451-61.
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2002: Saeki Tomoyuki; Mhashilkar Abner; Swanson Xin; Zou-Yang X Helena; Sieger Kerry; Kawabe Shinichiro; Branch Cynthia D; Zumstein Louis; Meyn Raymond E; Roth Jack A; Chada Sunil; Ramesh Rajagopal
Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo.
Oncogene 2002;21(29):4558-66.
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2002: Caudell Eva G; Mumm John B; Poindexter Nancy; Ekmekcioglu Suhendan; Mhashilkar Abner M; Yang Xiaohong Helena; Retter Mark W; Hill Paul; Chada Sunil; Grimm Elizabeth A
The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6041-6.
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2002: Pataer Abujiang; Vorburger Stephan A; Barber Glen N; Chada Sunil; Mhashilkar Abner M; Zou-Yang Helena; Stewart Alexis L; Balachandran Siddharth; Roth Jack A; Hunt Kelly K; Swisher Stephen G
Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).
Cancer research 2002;62(8):2239-43.
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2002: Mhashilkar A M; Doebis C; Seifert M; Busch A; Zani C; Soo Hoo J; Nagy M; Ritter T; Volk H-D; Marasco W A
Intrabody-mediated phenotypic knockout of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes.
Gene therapy 2002;9(5):307-19.
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2001: Ekmekcioglu S; Ellerhorst J; Mhashilkar A M; Sahin A A; Read C M; Prieto V G; Chada S; Grimm E A
Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas.
International journal of cancer. Journal international du cancer 2001;94(1):54-9.
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2001: Mhashilkar A; Chada S; Roth J A; Ramesh R
Gene therapy. Therapeutic approaches and implications.
Biotechnology advances 2001;19(4):279-97.
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2001: Mhashilkar A M; Schrock R D; Hindi M; Liao J; Sieger K; Kourouma F; Zou-Yang X H; Onishi E; Takh O; Vedvick T S; Fanger G; Stewart L; Watson G J; Snary D; Fisher P B; Saeki T; Roth J A; Ramesh R; Chada S
Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy.
Molecular medicine (Cambridge, Mass.) 2001;7(4):271-82.
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2000: Saeki T; Mhashilkar A; Chada S; Branch C; Roth J A; Ramesh R
Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro.
Gene therapy 2000;7(23):2051-7.
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2000: Li X; Multon M C; Henin Y; Schweighoffer F; Venot C; Josef J; Zhou C; LaVecchio J; Stuckert P; Raab M; Mhashilkar A; Tocque B; Marasco W A
Grb3-3 is up-regulated in HIV-1-infected T-cells and can potentiate cell activation through NFATc.
The Journal of biological chemistry 2000;275(40):30925-33.
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2000: Li X; Multon M C; Henin Y; Schweighoffer F; Venot C; LaVecchio J; Josef J; Stuckert P; Mhashilkar A; Tocqué B; Marasco W A
Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes.
Biochemical and biophysical research communications 2000;276(1):362-70.
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1999: Günzburg W; Mhashilkar A M; Hindi M
Technology evaluation: StealthVector (HIV) Enzo.
Current opinion in molecular therapeutics 1999;1(5):651-7.
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1999: Mhashilkar A M; LaVecchio J; Eberhardt B; Porter-Brooks J; Boisot S; Dove J H; Pumphrey C; Li X; Weissmahr R N; Ring D B; Ramstedt U; Marasco W A
Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies.
Human gene therapy 1999;10(9):1453-67.
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1998: Biswas D K; Mhashilkar A M; Ewaniuk D S; Pezza J A; Oh L M; Kannangara G S; Tius M A; Pardee A B
Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;18(5):426-34.
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1998: Poznansky M C; Foxall R; Mhashilkar A; Coker R; Jones S; Ramstedt U; Marasco W
Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat.
Human gene therapy 1998;9(4):487-96.
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1998: Vallat A V; De Girolami U; He J; Mhashilkar A; Marasco W; Shi B; Gray F; Bell J; Keohane C; Smith T W; Gabuzda D
Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.
The American journal of pathology 1998;152(1):167-78.
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1997: Mhashilkar A M; Biswas D K; LaVecchio J; Pardee A B; Marasco W A
Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.
Journal of virology 1997;71(9):6486-94.
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1997: Levin R; Mhashilkar A M; Dorfman T; Bukovsky A; Zani C; Bagley J; Hinkula J; Niedrig M; Albert J; Wahren B; Göttlinger H G; Marasco W A
Inhibition of early and late events of the HIV-1 replication cycle by cytoplasmic Fab intrabodies against the matrix protein, p17.
Molecular medicine (Cambridge, Mass.) 1997;3(2):96-110.
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1995: Mhashilkar A M; Bagley J; Chen S Y; Szilvay A M; Helland D G; Marasco W A
Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies.
The EMBO journal 1995;14(7):1542-51.
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