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Francesco Michelangeli

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Pei Lai; Francesco Michelangeli
Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).
Fawaz Al-Mousa; Francesco Michelangeli
Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells.
Pei Lai; Nga Chi Yip; Francesco Michelangeli
Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels.

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2012: Pei Lai; Francesco Michelangeli
Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).
Biochemical and biophysical research communications 2012;424(3):616-9.
2012: Fawaz Al-Mousa; Francesco Michelangeli
Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells.
PloS one 2012;7(4):e33059.
2011: Pei Lai; Nga Chi Yip; Francesco Michelangeli
Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels.
FEBS letters 2011;585(14):2291-4.
2011: Francesco Michelangeli; J Malcolm East
A diversity of SERCA Ca2+ pump inhibitors.
Biochemical Society transactions 2011;39(3):789-97.
2011: J Malcolm East; Francesco Michelangeli
Recent advances in Membrane Biochemistry.
Biochemical Society transactions 2011;39(3):703-6.
2009: Pei Lai; Francesco Michelangeli
Changes in expression and activity of the secretory pathway Ca2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations.
Bioscience reports 2009;29(6):397-404.
2009: Fawaz Al-Mousa; Francesco Michelangeli
Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps.
Pharmacological reports : PR 2009;61(5):838-42.
2009: Sarah Costello; Francesco Michelangeli; Katherine Nash; Linda Lefievre; Jennifer Morris; Gisela Machado-Oliveira; Christopher L R Barratt; Jackson C Kirkman-Brown; Stephen Publicover
Ca2+-stores in sperm: their identities and functions.
Reproduction (Cambridge, England) 2009;138(3):425-37.
2008: Oluseye A Ogunbayo; Robert M Harris; Rosemary H Waring; Christopher J Kirk; Francesco Michelangeli
Inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by flavonoids: a quantitative structure-activity relationship study.
IUBMB life 2008;60(12):853-8.
2008: Francesco Michelangeli; Oluseye A Ogunbayo; Laura L Wootton; Pei F Lai; Fawaz Al-Mousa; Robert M Harris; Rosemary H Waring; Christopher J Kirk
Endocrine disrupting alkylphenols: structural requirements for their adverse effects on Ca2+ pumps, Ca2+ homeostasis & Sertoli TM4 cell viability.
Chemico-biological interactions 2008;176(2-3):220-6.
2008: Oluseye A Ogunbayo; Pei F Lai; Thomas J Connolly; Francesco Michelangeli
Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(4):943-52.
2007: Oluseye A Ogunbayo; Francesco Michelangeli
The widely utilized brominated flame retardant tetrabromobisphenol A (TBBPA) is a potent inhibitor of the SERCA Ca2+ pump.
The Biochemical journal 2007;408(3):407-15.
2007: Oluseye A Ogunbayo; Karina T Jensen; Francesco Michelangeli
The interaction of the brominated flame retardant: tetrabromobisphenol A with phospholipid membranes.
Biochimica et biophysica acta 2007;1768(6):1559-66.
2007: Sarah J Conner; Linda Lefièvre; Jackson C Kirkman-Brown; Francesco Michelangeli; C Jimenez-Gonzalez; G S M Machado-Oliveira; Katherine L Pixton; Ian A Brewis; Christopher L R Barratt; Stephen Publicover
Understanding the physiology of pre-fertilisation events in the human spermatozoa--a necessary prerequisite to developing rational therapy.
Society of Reproduction and Fertility supplement 2007;63():237-55.
2006: C Jimenez-Gonzalez; Francesco Michelangeli; Claire V Harper; Christopher L R Barratt; Stephen Publicover
Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores.
Human reproduction update 2006;12(3):253-67.
2006: Laura L Wootton; Francesco Michelangeli
The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.
The Journal of biological chemistry 2006;281(11):6970-6.
2005: Claire Harper; Laura L Wootton; Francesco Michelangeli; Linda Lefièvre; Christopher L R Barratt; Stephen Publicover
Secretory pathway Ca(2+)-ATPase (SPCA1) Ca(2)+ pumps, not SERCAs, regulate complex [Ca(2+)](i) signals in human spermatozoa.
Journal of cell science 2005;118(Pt 8):1673-85.
2005: Francesco Michelangeli; Oluseye A Ogunbayo; Laura L Wootton
A plethora of interacting organellar Ca2+ stores.
Current opinion in cell biology 2005;17(2):135-40.
2004: Laura L Wootton; Cymone C H Argent; Mark Wheatley; Francesco Michelangeli
The expression, activity and localisation of the secretory pathway Ca2+ -ATPase (SPCA1) in different mammalian tissues.
Biochimica et biophysica acta 2004;1664(2):189-97.
2003: Shahla Zafar Khan; Christopher J Kirk; Francesco Michelangeli
Alkylphenol endocrine disrupters inhibit IP3-sensitive Ca2+ channels.
Biochemical and biophysical research communications 2003;310(2):261-6.
2003: Christopher J Kirk; Laura Bottomley; Nicholas Minican; Howard Carpenter; Selena Shaw; Navdeep Kohli; Matthew Winter; Edwin W Taylor; Rosemary H Waring; Francesco Michelangeli; Robert M Harris
Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2003;135(1):1-8.
2003: Masood-ul-Hassan Javed; Francesco Michelangeli
Enzymatic method for assaying calcium in serum with Ca++ -ATPase.
Experimental & molecular medicine 2003;35(1):17-22.
2003: Jeanette L Dyer; Hamid Mobasheri; Edward J A Lea; Alan P Dawson; Francesco Michelangeli
Differential effect of PKA on the Ca2+ release kinetics of the type I and III InsP3 receptors.
Biochemical and biophysical research communications 2003;302(1):121-6.
2002: Jonathan G Bilmen; Francesco Michelangeli
Inhibition of the type 1 inositol 1,4,5-trisphosphate receptor by 2-aminoethoxydiphenylborate.
Cellular signalling 2002;14(11):955-60.
2002: Jonathan G Bilmen; Laura L Wootton; Francesco Michelangeli
The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.
Archives of biochemistry and biophysics 2002;406(1):55-64.
2002: Jonathan G Bilmen; Laura L Wootton; Francesco Michelangeli
The inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by macrocyclic lactones and cyclosporin A.
The Biochemical journal 2002;366(Pt 1):255-63.
2002: Jonathan G Bilmen; Laura L Wootton; Rita E Godfrey; Oliver S Smart; Francesco Michelangeli
Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB). 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites.
European journal of biochemistry / FEBS 2002;269(15):3678-87.
2002: Jeanette L Dyer; Shahla Zafar Khan; Jonathan G Bilmen; Stuart R Hawtin; Mark Wheatley; Masood-ul-Hassan Javed; Francesco Michelangeli
Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.
Cell calcium 2002;31(1):45-52.
2001: Jonathan G Bilmen; Shahla Zafar Khan; M H Javed; Francesco Michelangeli
Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.
European journal of biochemistry / FEBS 2001;268(23):6318-27.
2001: Jeanette L Dyer; Francesco Michelangeli
Inositol 1,4,5-trisphosphate receptor isoforms show similar Ca2+ release kinetics.
Cell calcium 2001;30(4):245-50.
2001: Shahla Zafar Khan; Jeanette L Dyer; Francesco Michelangeli
Inhibition of the type 1 inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by calmodulin antagonists.
Cellular signalling 2001;13(1):57-63.
2000: Shahla Zafar Khan; CL Longland; Francesco Michelangeli
The effects of phenothiazines and other calmodulin antagonists on the sarcoplasmic and endoplasmic reticulum Ca(2+) pumps.
Biochemical pharmacology 2000;60(12):1797-806.
2000: SC Tovey; Jeanette L Dyer; Rita E Godfrey; Shahla Zafar Khan; Jonathan G Bilmen; M Mezna; Francesco Michelangeli
Subtype identification and functional properties of inositol 1,4, 5-trisphosphate receptors in heart and aorta.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(6):581-90.
2000: CL Longland; Jeanette L Dyer; Francesco Michelangeli
The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor.
European journal of pharmacology 2000;408(3):219-25.
2000: Philip J Hughes; H McLellan; D A Lowes; S Z Kahn; Jonathan G Bilmen; SC Tovey; Rita E Godfrey; Robert H Michell; Christopher J Kirk; Francesco Michelangeli
Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps.
Biochemical and biophysical research communications 2000;277(3):568-74.
2000: Masood-ul-Hassan Javed; Tahira Naru; Francesco Michelangeli
An endogenous inhibitor of Ca++-ATPase from human placenta.
Journal of enzyme inhibition 2000;15(2):163-70.
1999: CL Longland; M Mezna; Francesco Michelangeli
The mechanism of inhibition of the Ca2+-ATPase by mastoparan. Mastoparan abolishes cooperative ca2+ binding.
The Journal of biological chemistry 1999;274(21):14799-805.
1999: Masood-ul-Hassan Javed; Francesco Michelangeli; Peter Lund
GroEL protects the sarcoplasmic reticulum Ca(++)-dependent ATPase from inactivation in vitro.
Biochemistry and molecular biology international 1999;47(4):631-8.
1998: M Mezna; Francesco Michelangeli
The role of inorganic phosphate in regulating the kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release: a putative role for endoplasmic reticulum phosphate transporters.
Biochimica et biophysica acta 1998;1373(1):270-6.
1998: SC Tovey; CL Longland; M Mezna; Francesco Michelangeli
2-Hydroxycarbazole induces Ca2+ release from sarcoplasmic reticulum by activating the ryanodine receptor.
European journal of pharmacology 1998;354(2-3):245-51.
1998: CL Longland; Francesco Michelangeli
The effect of mastoparan on the E2-E1 transition of the SR Ca(2+)-ATPase.
Biochemical Society transactions 1998;26(3):S305.
1998: M Mezna; CL Longland; Francesco Michelangeli
The effects of thimerosal on the purified InsP3 receptor.
Biochemical Society transactions 1998;26(3):S290.
1998: P Sharma; Yuan Gao; CL Longland; Francesco Michelangeli; G Strasburg; D J Bigelow; Valerie B Patchell; S Victor Perry; Barry A Levine
Interaction of the SR CaATPase with the cytoplasmic region of phospholamban.
Biochemical Society transactions 1998;26(3):S228.
1998: CL Longland; M Mezna; Ulo Langel; Mattias Hällbrink; Ursel Soomets; Mark Wheatley; Francesco Michelangeli; John Howl
Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.
Cell calcium 1998;24(1):27-34.
1997: M Mezna; Francesco Michelangeli
The effect of phosphate transporter inhibitors on the InsP3-induced Ca2+ release.
Biochemical Society transactions 1997;25(3):451S.
1997: M Mezna; Ulo Langel; Mattias Hällbrink; Mark Wheatley; Francesco Michelangeli; John Howl
Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.
Biochemical Society transactions 1997;25(3):450S.
1997: Armando Genazzani; M Mezna; D M Dickey; Francesco Michelangeli; Timothy F Walseth; Antony Galione
Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg.
British journal of pharmacology 1997;121(7):1489-95.
1997: M Mezna; Francesco Michelangeli
Effects of thimerosal on the transient kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release from cerebellar microsomes.
The Biochemical journal 1997;325 ( Pt 1)():177-82.
1997: SC Tovey; Rita E Godfrey; Philip J Hughes; M Mezna; Stephen D Minchin; K Mikoshiba; Francesco Michelangeli
Identification and characterization of inositol 1,4,5-trisphosphate receptors in rat testis.
Cell calcium 1997;21(4):311-9.
1997: Armando Genazzani; M Mezna; R J Summerhill; Antony Galione; Francesco Michelangeli
Kinetic properties of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release.
The Journal of biological chemistry 1997;272(12):7669-75.
1996: M Mezna; Francesco Michelangeli
The effects of inositol 1,4,5-trisphosphate (InsP3) analogues on the transient kinetics of Ca2+ release from cerebellar microsomes. InsP3 analogues act as partial agonists.
The Journal of biological chemistry 1996;271(50):31818-23.
1996: Francesco Michelangeli; SC Tovey; D A Lowes; R F Tien; M Mezna; H McLellan; P Hughes
Can phenolic plasticising agents affect testicular development by disturbing intracellular calcium homeostasis?
Biochemical Society transactions 1996;24(2):293S.
1996: M Mezna; T Patchick; SC Tovey; Francesco Michelangeli
Effects of aliphatic alcohols on the ER calcium pumps and InsP3 receptors from porcine cerebellum.
Biochemical Society transactions 1996;24(2):292S.
1996: M Mezna; T Patchick; SC Tovey; Francesco Michelangeli
Inhibition of the cerebellar inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by ethanol and other aliphatic alcohols.
The Biochemical journal 1996;314 ( Pt 1)():175-9.
1995: M Mezna; Francesco Michelangeli
Alkali metal ion dependence of inositol 1,4,5-trisphosphate-induced calcium release from rat cerebellar microsomes.
The Journal of biological chemistry 1995;270(47):28097-102.
1995: Francesco Michelangeli; M Mezna; SC Tovey; L G Sayers
Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor.
Neuropharmacology 1995;34(9):1111-22.
1995: SC Tovey; M Mezna; Francesco Michelangeli
The effects of cholesterol hemisuccinate and other membrane fluidity perturbing agents on inositol 1,4,5-trisphosphate-induced calcium release from cerebellar microsomes.
Biochemical Society transactions 1995;23(3):429S.
1995: M Mezna; Francesco Michelangeli
Modulation of the inositol 1,4,5-trisphosphate-sensitive calcium channel from rat cerebellum by alkali metal ions.
Biochemical Society transactions 1995;23(3):428S.
1994: G R Brown; S L Benyon; C J Kirk; M Wictome; J Malcolm East; Anthony G Lee; Francesco Michelangeli
Characterisation of a novel Ca2+ pump inhibitor (bis-phenol) and its effects on intracellular Ca2+ mobilization.
Biochimica et biophysica acta 1994;1195(2):252-8.
1994: G R Brown; R Morgan; Francesco Michelangeli
Analysis of the interactions of calcium and trifluoroperazine with skeletal muscle calsequestrin.
Biochemical Society transactions 1994;22(2):159S.
1994: L G Sayers; Francesco Michelangeli
The inositol 1,4,5-trisphosphate-sensitive Ca2+ channel is inhibited by polyamines.
Biochemical Society transactions 1994;22(2):152S.
1993: L G Sayers; Francesco Michelangeli
The inhibition of the inositol 1,4,5-trisphosphate receptor from rat cerebellum by spermine and other polyamines.
Biochemical and biophysical research communications 1993;197(3):1203-8.
1993: L G Sayers; Francesco Michelangeli
The effects of tetrahexyl ammonium cations (THA+) on inositol 1,4,5-trisphosphate-induced calcium release from porcine cerebellar microsomes: THA+ can induce calcium release selectively from the InsP3-sensitive calcium stores.
Biochimica et biophysica acta 1993;1152(1):177-83.
1993: G R Brown; S L Benyon; J Malcolm East; Francesco Michelangeli
Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).
Biochemical Society transactions 1993;21(2):106S.
1993: L G Sayers; Francesco Michelangeli
The effects of tetrahexylammonium chloride on calcium mobilization from cerebellar microsomes.
Biochemical Society transactions 1993;21(2):105S.
1993: L G Sayers; G R Brown; Robert H Michell; Francesco Michelangeli
The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes.
The Biochemical journal 1993;289 ( Pt 3)():883-7.
1993: Francesco Michelangeli
The effects of amino acid-reactive reagents on the functioning of the inositol 1,4,5-trisphosphate-sensitive calcium channel from rat cerebellum.
Cellular signalling 1993;5(1):33-9.
1992: M Wictome; Francesco Michelangeli; Anthony G Lee; J Malcolm East
The inhibitors thapsigargin and 2,5-di(tert-butyl)-1,4-benzohydroquinone favour the E2 form of the Ca2+,Mg(2+)-ATPase.
FEBS letters 1992;304(2-3):109-13.
1992: Francesco Michelangeli; A DaSilva; L Sayers; Geoffrey Brown
The effects of thimerosal and cyclopiazonic acid on the Ca(2+)-pumps from rat cerebellum microsomes.
Biochemical Society transactions 1992;20(2):205S.
1992: G R Brown; L G Sayers; C J Kirk; Robert H Michell; Francesco Michelangeli
The opening of the inositol 1,4,5-trisphosphate-sensitive Ca2+ channel in rat cerebellum is inhibited by caffeine.
The Biochemical journal 1992;282 ( Pt 2)():309-12.
1991: Francesco Michelangeli; F M Munkonge
Methods of reconstitution of the purified sarcoplasmic reticulum (Ca(2+)-Mg2+)-ATPase using bile salt detergents to form membranes of defined lipid to protein ratios or sealed vesicles.
Analytical biochemistry 1991;194(2):231-6.
1991: Ana Mata; J Colyer; Francesco Michelangeli; Anthony G Lee; J Malcolm East
The effect of a monoclonal antibody on specific steps of the reaction sequence of the (Ca(2+)-Mg(2+))-ATPase from sarcoplasmic reticulum.
Biochemical Society transactions 1991;19(2):205S.
1991: Francesco Michelangeli
Fluo-3 an ideal calcium indicator for measuring calcium fluxes in SR and ER.
Biochemical Society transactions 1991;19(2):183S.
1991: Francesco Michelangeli; E A Grimes; J Malcolm East; Anthony G Lee
Effects of phospholipids on the function of (Ca2(+)-Mg2+)-ATPase.
Biochemistry 1991;30(2):342-51.
1990: Francesco Michelangeli; M J Robson; J Malcolm East; Anthony G Lee
The conformation of pyrethroids bound to lipid bilayers.
Biochimica et biophysica acta 1990;1028(1):49-57.
1990: Francesco Michelangeli; M J Robson; J Malcolm East; Anthony G Lee
Fluorescence and kinetic studies of the interactions of pyrethroids with the (Ca2(+) + Mg2+)-ATPase.
Biochimica et biophysica acta 1990;1028(1):58-66.
1990: Francesco Michelangeli; S Orlowski; Philippe Champeil; E A Grimes; J Malcolm East; Anthony G Lee
Effects of phospholipids on binding of calcium to (Ca2(+)-Mg2(+)-ATPase.
Biochemistry 1990;29(36):8307-12.
1990: Ana Mata; Francesco Michelangeli; Anthony G Lee; J Malcolm East
Effect of the detergent C12E8 on the binding of monoclonal antibodies to the (Ca2(+)-Mg2+)-ATPase of rabbit skeletal sarcoplasmic reticulum.
Biochemical Society transactions 1990;18(4):603.
1990: Francesco Michelangeli; J Malcolm East; Anthony G Lee
Structural effects on the interaction of sterols with the (Ca2+ + Mg2+)-ATPase.
Biochimica et biophysica acta 1990;1025(1):99-108.
1990: Francesco Michelangeli; J Colyer; J Malcolm East; Anthony G Lee
Effect of pH on the activity of the Ca2+ + Mg2(+)-activated ATPase of sarcoplasmic reticulum.
The Biochemical journal 1990;267(2):423-9.
1990: Francesco Michelangeli; S Orlowski; Philippe Champeil; J Malcolm East; Anthony G Lee
Mechanism of inhibition of the (Ca2(+)-Mg2+)-ATPase by nonylphenol.
Biochemistry 1990;29(12):3091-101.
1989: Anthony G Lee; Francesco Michelangeli; J Malcolm East
Tests for the importance of fluidity for the function of membrane proteins.
Biochemical Society transactions 1989;17(6):962-4.
1989: E A Grimes; F M Munkonge; I Matthews; A Burgess; Ana Mata; Francesco Michelangeli; J Malcolm East; Anthony G Lee
Use of antibodies to detect chemically cross-linked products from sarcoplasmic reticulum.
Biochemical Society transactions 1989;17(6):1103-4.
1989: Francesco Michelangeli; I Henderson; J Malcolm East; Anthony G Lee
Interaction of sterols with phospholipid bilayers and the (Ca2(+)-Mg2+)-ATPase.
Biochemical Society transactions 1989;17(6):1095-6.
1988: F Munkonge; Francesco Michelangeli; E K Rooney; J Malcolm East; Anthony G Lee
Effect of phospholipid:protein ratio on the state of aggregation of the (Ca2+-Mg2+)-ATPase.
Biochemistry 1988;27(18):6800-5.