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Paul Michels

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J Bero; Véronique Hannaert; M-F Hérent; Paul A M Michels; C Beaufay; Joëlle Quetin-Leclercq
Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase.
Melisa Gualdrón-López; Paul A M Michels
Processing of the glycosomal matrix-protein import receptor PEX5 of Trypanosoma brucei.
Simone Pieretti; Federica Prati; Leonardo Scapozza; Barbara M Bakker; Christian Bergamini; Maria Laura Bolognesi; Reto Brun; Giovanni Capranico; Romana Fato; Jurgen Haanstra; Giorgio Lenaz; Muriel Mazet; Paul A M Michels; Remo Perozzo; Andrea Cavalli
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

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All Publications

2013: J Bero; Véronique Hannaert; M-F Hérent; Paul A M Michels; C Beaufay; Joëlle Quetin-Leclercq
Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2013;20(3-4):270-4.
2013: Melisa Gualdrón-López; Paul A M Michels
Processing of the glycosomal matrix-protein import receptor PEX5 of Trypanosoma brucei.
Biochemical and biophysical research communications 2013;431(1):98-103.
2013: Simone Pieretti; Federica Prati; Leonardo Scapozza; Barbara M Bakker; Christian Bergamini; Maria Laura Bolognesi; Reto Brun; Giovanni Capranico; Romana Fato; Jurgen Haanstra; Giorgio Lenaz; Muriel Mazet; Paul A M Michels; Remo Perozzo; Andrea Cavalli
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
PLoS neglected tropical diseases 2013;7(1):e2012.
2013: Melisa Gualdrón-López; Luisana Avilán; Ana Brennand; Paul A M Michels
Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs.
Parasitology 2013;140(1):1-20.
2012: Hugh P Morgan; Matthew W Nowicki; Min Shen; Henrike Veith; Douglas S Auld; Elizabeth A Blackburn; Matthew B Boxer; Linda A Fothergill-Gilmore; Iain W McNae; Paul A M Michels; Martin J Walsh; Martin A Wear; Malcolm D Walkinshaw
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
The Biochemical journal 2012;448(1):67-72.
2012: Emilie Verplaetse; Nathalie Chevalier; Melisa Gualdrón-López; Paul A M Michels
Studies on the organization of the docking complex involved in matrix protein import into glycosomes of Trypanosoma brucei.
Biochemical and biophysical research communications 2012;424(4):781-5.
2012: Patrícia R Feliciano; Shreedhara Gupta; Paul A M Michels; Antonio J Costa-Filho; Marcelo Dias-Baruffi; Fabio Dyszy; M Cristina Nonato
Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties.
International journal of biological macromolecules 2012;51(1-2):25-31.
2012: Ana Brennand; Daniel J Rigden; Paul A M Michels
Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis.
FEBS letters 2012;586(13):1765-71.
2012: Gustavo F Mercaldi; Paul A M Michels; Humberto M Pereira; Artur T Cordeiro; Otavio Henrique Thiemann
Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase.
The FEBS journal 2012;279(11):2012-21.
2012: Melisa Gualdron-López; J Kalervo Hiltunen; Paul A M Michels; Ilkka J Miinalainen; Miia H Vapola; Vasily D Antonenkov
Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei.
PloS one 2012;7(4):e34530.
2011: Fazia Adyani Ahmad Fuad; Iain W McNae; Paul A M Michels; Hugh P Morgan; Matthew W Nowicki; Lorna J Eades; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo.
Metallomics : integrated biometal science 2011;3(12):1310-7.
2011: Muriel Mazet; Jorge Morales; Pauline Morand; Rik K Wierenga; Frédéric Bringaud; Antti M Haapalainen; Rajesh K Harijan; Tiila-Riika Kiema; Paul A M Michels
The characterization and evolutionary relationships of a trypanosomal thiolase.
International journal for parasitology 2011;41(12):1273-83.
2011: Paul A M Michels; Luisana Avilán
The NAD+ metabolism of Leishmania, notably the enzyme nicotinamidase involved in NAD+ salvage, offers prospects for development of anti-parasite chemotherapy.
Molecular microbiology 2011;82(1):4-8.
2011: Hugh P Morgan; Matthew W Nowicki; Wenhe Zhong; Douglas S Auld; Linda A Fothergill-Gilmore; Iain W McNae; Paul A M Michels; Malcolm D Walkinshaw
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
The Journal of biological chemistry 2011;286(36):31232-40.
2011: Andrés Alloatti; Silvia Altabe; Gladys Deumer; Melisa Gualdrón-López; Shreedhara Gupta; Paul A M Michels; Paul A Nguewa; Pierre Wallemacq; Antonio D Uttaro
Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei.
Biochemical and biophysical research communications 2011;412(2):286-90.
2011: Ana Brennand; Melisa Gualdrón-López; Isabelle Coppens; Daniel J Rigden; Michael L Ginger; Paul A M Michels
Autophagy in parasitic protists: unique features and drug targets.
Molecular and biochemical parasitology 2011;177(2):83-99.
2011: Shreedhara Gupta; Artur Cordeiro; Paul A M Michels
Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids.
Molecular and biochemical parasitology 2011;176(2):112-5.
2011: Mariana Igoillo-Esteve; Muriel Mazet; Gladys Deumer; Pierre Wallemacq; Paul A M Michels
Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity.
International journal for parasitology 2011;41(3-4):429-38.
2011: Shreedhara Gupta; Mariana Igoillo-Esteve; Paul A M Michels; Artur Cordeiro
Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery.
Molecular biology international 2011;2011():135701.
2011: Luisana Avilán; Melisa Gualdrón-López; Wilfredo Quiñones; Limari González-González; Véronique Hannaert; Paul A M Michels; Juan Luis Concepción
Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target.
Enzyme research 2011;2011():932549.
2011: Jurgen Haanstra; Eduard J Kerkhoven; Arjen van Tuijl; Marjolein Blits; Martin Wurst; Rick van Nuland; Marie-Astrid Albert; Paul A M Michels; Jildau Bouwman; Christine Clayton; Hans V Westerhoff; Barbara M Bakker
A domino effect in drug action: from metabolic assault towards parasite differentiation.
Molecular microbiology 2011;79(1):94-108.
2010: Nathalie Galland; Paul A M Michels
Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy.
European journal of cell biology 2010;89(9):621-37.
2010: Nathalie Galland; Stéphane de Walque; Frank Voncken; Christophe Verlinde; Paul A M Michels
An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes.
Molecular and biochemical parasitology 2010;171(1):45-9.
2010: Hugh P Morgan; Iain W McNae; Matthew W Nowicki; Véronique Hannaert; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model.
The Journal of biological chemistry 2010;285(17):12892-8.
2010: Hugh P Morgan; Iain W McNae; Kun-Yi Hsin; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 3):215-8.
2010: Andrés Alloatti; Shreedhara Gupta; Melisa Gualdrón-López; Mariana Igoillo-Esteve; Paul A Nguewa; Gladys Deumer; Pierre Wallemacq; Silvia G Altabe; Paul A M Michels; Antonio D Uttaro
Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target.
PloS one 2010;5(12):e14239.
2010: Ana Judith Cáceres; Paul A M Michels; Véronique Hannaert
Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei.
Molecular and biochemical parasitology 2010;169(1):50-4.
2009: Matthew W Nowicki; Buabarn Kuaprasert; Iain W McNae; Hugh P Morgan; Marjorie M Harding; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass.
Journal of molecular biology 2009;394(3):535-43.
2009: Artur Cordeiro; Otavio H Thiemann; Paul A M Michels
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.
Bioorganic & medicinal chemistry 2009;17(6):2483-9.
2009: Emilie Verplaetse; Daniel J Rigden; Paul A M Michels
Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei.
Biochimica et biophysica acta 2009;1793(3):516-27.
2009: Iain W McNae; José Martinez-Oyanedel; Jeffrey W Keillor; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.
Journal of molecular biology 2009;385(5):1519-33.
2008: Jurgen Haanstra; Arjen van Tuijl; Peter Kessler; Willem Reijnders; Paul A M Michels; Hans V Westerhoff; Marilyn Parsons; Barbara M Bakker
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17718-23.
2008: Lindsay B Tulloch; Hugh P Morgan; Véronique Hannaert; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state.
Journal of molecular biology 2008;383(3):615-26.
2008: Parthasrathy Sampathkumar; Claudia Roach; Paul A M Michels; Wim G J Hol
Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
Journal of molecular biology 2008;381(4):867-80.
2008: Fred R Opperdoes; Paul A M Michels
Complex I of Trypanosomatidae: does it exist?
Trends in parasitology 2008;24(7):310-7.
2008: Matthew W Nowicki; Lindsay B Tulloch; Liam Worralll; Iain W McNae; Véronique Hannaert; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw; Nicholas J Turner
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis.
Bioorganic & medicinal chemistry 2008;16(9):5050-61.
2008: Didier Vertommen; Joris Van Roy; Jean-Pierre Szikora; Mark H Rider; Paul A M Michels; Fred R Opperdoes
Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei.
Molecular and biochemical parasitology 2008;158(2):189-201.
2007: Ana Judith Cáceres; Wilfredo Quiñones; Melisa Gualdrón; Artur Cordeiro; Luisana Avilán; Paul A M Michels; Juan Luis Concepción
Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp.
Molecular and biochemical parasitology 2007;156(2):235-45.
2007: Artur Cordeiro; Ana Judith Cáceres; Didier Vertommen; Juan Luis Concepción; Paul A M Michels; Wim Versées
The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes.
Journal of molecular biology 2007;372(5):1215-26.
2007: Fred R Opperdoes; Paul A M Michels
Horizontal gene transfer in trypanosomatids.
Trends in parasitology 2007;23(10):470-6.
2007: Wilfredo Quiñones; Priscila Peña; Maria Domingo-Sananes; Ana Judith Cáceres; Paul A M Michels; Luisana Avilan; Juan Luis Concepción
Leishmania mexicana: molecular cloning and characterization of enolase.
Experimental parasitology 2007;116(3):241-51.
2007: Nathalie Galland; Fabian Demeure; Véronique Hannaert; Emilie Verplaetse; Didier Vertommen; Patrick Van Der Smissen; Pierre J Courtoy; Paul A M Michels
Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei.
Biochimica et biophysica acta 2007;1773(4):521-35.
2007: José Martinez-Oyanedel; Iain W McNae; Matthew W Nowicki; Jeffrey W Keillor; Paul A M Michels; Linda A Fothergill-Gilmore; Malcolm D Walkinshaw
The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei.
Journal of molecular biology 2007;366(4):1185-98.
2006: Paul A M Michels; Frédéric Bringaud; Murielle Herman; Véronique Hannaert
Metabolic functions of glycosomes in trypanosomatids.
Biochimica et biophysica acta 2006;1763(12):1463-77.
2006: Daniel G Guerra; Anabelle Decottignies; Barbara M Bakker; Paul A M Michels
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp.
Molecular and biochemical parasitology 2006;149(2):155-69.
2006: Murielle Herman; Stuart Gillies; Paul A M Michels; Daniel J Rigden
Autophagy and related processes in trypanosomatids: insights from genomic and bioinformatic analyses.
Autophagy 2006;2(2):107-18.
2006: Chantal Dax; Francis Duffieux; Nicolas Chabot; Mathieu Coincon; Jurgen Sygusch; Paul A M Michels; Casimir Blonski
Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei.
Journal of medicinal chemistry 2006;49(5):1499-502.
2006: Paul A M Michels; Daniel J Rigden
Evolutionary analysis of fructose 2,6-bisphosphate metabolism.
IUBMB life 2006;58(3):133-41.
2006: Cédric Yernaux; Marc Fransen; Chantal Brees; Stephan Lorenzen; Paul A M Michels
Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting.
Molecular membrane biology 2006;23(2):157-72.
2006: Hanane Krazy; Paul A M Michels
Identification and characterization of three peroxins--PEX6, PEX10 and PEX12--involved in glycosome biogenesis in Trypanosoma brucei.
Biochimica et biophysica acta 2006;1763(1):6-17.
2005: Marie-Astrid Albert; Jurgen Haanstra; Véronique Hannaert; Joris Van Roy; Fred R Opperdoes; Barbara M Bakker; Paul A M Michels
Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei.
The Journal of biological chemistry 2005;280(31):28306-15.
2005: Nathalie Chevalier; Luc Bertrand; Mark H Rider; Fred R Opperdoes; Daniel J Rigden; Paul A M Michels
6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis.
The FEBS journal 2005;272(14):3542-60.
2005: Paul A M Michels; Juliette Moyersoen; Hanane Krazy; Nathalie Galland; Murielle Herman; Véronique Hannaert
Peroxisomes, glyoxysomes and glycosomes (review).
Molecular membrane biology 2005;22(1-2):133-45.
2004: Juliette Moyersoen; Jungwoo Choe; Erkang Fan; Wim G J Hol; Paul A M Michels
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target.
FEMS microbiology reviews 2004;28(5):603-43.
2004: Mark H Rider; Luc Bertrand; Didier Vertommen; Paul A M Michels; Guy G Rousseau; Louis Hue
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.
The Biochemical journal 2004;381(Pt 3):561-79.
2004: Artur Cordeiro; Paul A M Michels; Luiz F Delboni; Otavio Henrique Thiemann
The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features.
European journal of biochemistry / FEBS 2004;271(13):2765-72.
2004: Artur Cordeiro; Renaud Hardré; Paul A M Michels; Laurent Salmon; Luiz F Delboni; Otavio Henrique Thiemann
Leishmania mexicana mexicana glucose-6-phosphate isomerase: crystallization, molecular-replacement solution and inhibition.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 5):915-9.
2004: Daniel G Guerra; Didier Vertommen; Linda A Fothergill-Gilmore; Fred R Opperdoes; Paul A M Michels
Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification.
European journal of biochemistry / FEBS 2004;271(9):1798-810.
2003: Jungwoo Choe; Juliette Moyersoen; Claudia Roach; Tyan L Carter; Erkang Fan; Paul A M Michels; Wim G J Hol
Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei.
Biochemistry 2003;42(37):10915-22.
2003: Sara M Molinas; Silvia Altabe; Fred R Opperdoes; Mark H Rider; Paul A M Michels; Antonio D Uttaro
The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage.
The Journal of biological chemistry 2003;278(38):36169-75.
2003: Maria Teresa da Silva Giotto; Véronique Hannaert; Didier Vertommen; Marcos V de A S Navarro; Mark H Rider; Paul A M Michels; Richard C Garratt; Daniel J Rigden
The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition.
Journal of molecular biology 2003;331(3):653-65.
2003: Véronique Hannaert; Marie-Astrid Albert; Daniel J Rigden; Maria Teresa da Silva Giotto; Otavio Henrique Thiemann; Richard C Garratt; Joris Van Roy; Fred R Opperdoes; Paul A M Michels
Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase.
European journal of biochemistry / FEBS 2003;270(15):3205-13.
2003: Jungwoo Choe; Daniel G Guerra; Paul A M Michels; Wim G J Hol
Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct.
Journal of molecular biology 2003;329(2):335-49.
2003: Juliette Moyersoen; Jungwoo Choe; Abhinav Kumar; Frank Voncken; Wim G J Hol; Paul A M Michels
Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins.
European journal of biochemistry / FEBS 2003;270(9):2059-67.
2003: Véronique Hannaert; Emma Saavedra; Francis Duffieux; Jean-Pierre Szikora; Daniel J Rigden; Paul A M Michels; Fred R Opperdoes
Plant-like traits associated with metabolism of Trypanosoma parasites.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1067-71.
2003: Ana Judith Cáceres; Ramon Portillo; Héctor Acosta; David Rosales; Wilfredo Quiñones; Luisana Avilan; Leiria Salazar; Michel Dubourdieu; Paul A M Michels; Juan Luis Concepción
Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi.
Molecular and biochemical parasitology 2003;126(2):251-62.
2002: Samantha Claustre; Colette Denier; Faouzi Lakhdar-Ghazal; Andrée Lougare; Claudia Lopez; Nathalie Chevalier; Paul A M Michels; Jacques Périé; Michèle Willson
Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition.
Biochemistry 2002;41(32):10183-93.
2002: Claudia López; Nathalie Chevalier; Véronique Hannaert; Daniel J Rigden; Paul A M Michels; José Luis Ramirez
Leishmania donovani phosphofructokinase. Gene characterization, biochemical properties and structure-modeling studies.
European journal of biochemistry / FEBS 2002;269(16):3978-89.
2002: Faouzi Lakhdar-Ghazal; Casimir Blonski; Michèle Willson; Paul A M Michels; Jacques Perie
Glycolysis and proteases as targets for the design of new anti-trypanosome drugs.
Current topics in medicinal chemistry 2002;2(5):439-56.
2002: Véronique Hannaert; Cédric Yernaux; Daniel J Rigden; Linda A Fothergill-Gilmore; Fred R Opperdoes; Paul A M Michels
The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis.
FEBS letters 2002;514(2-3):255-9.
2001: Juan Luis Concepción; CA Adjé; Wilfredo Quiñones; Nathalie Chevalier; Michel Dubourdieu; Paul A M Michels
The expression and intracellular distribution of phosphoglycerate kinase isoenzymes in Trypanosoma cruzi.
Molecular and biochemical parasitology 2001;118(1):111-21.
2001: Emeric Miclet; Véronique Stoven; Paul A M Michels; Fred R Opperdoes; Jean-Yves Lallemand; Francis Duffieux
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
The Journal of biological chemistry 2001;276(37):34840-6.
2001: Abhinav Kumar; Claudia Roach; Irwin Hirsh; Stewart Turley; S deWalque; Paul A M Michels; Wim G J Hol
An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
Journal of molecular biology 2001;307(1):271-82.
2001: Christophe Verlinde; Véronique Hannaert; Casimir Blonski; Michèle Willson; Jacques Périé; Linda A Fothergill-Gilmore; Fred R Opperdoes; Michael H Gelb; Wim G J Hol; Paul A M Michels
Glycolysis as a target for the design of new anti-trypanosome drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(1):50-65.
2000: Paul A M Michels; Véronique Hannaert; Frédéric Bringaud
Metabolic aspects of glycosomes in trypanosomatidae - new data and views.
Parasitology today (Personal ed.) 2000;16(11):482-9.
2000: Antonio D Uttaro; Silvia Altabe; Mark H Rider; Paul A M Michels; Fred R Opperdoes
A family of highly conserved glycosomal 2-hydroxyacid dehydrogenases from Phytomonas sp.
The Journal of biological chemistry 2000;275(41):31833-7.
2000: Francis Duffieux; Joris Van Roy; Paul A M Michels; Fred R Opperdoes
Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase.
The Journal of biological chemistry 2000;275(36):27559-65.
2000: D M Chudzik; Paul A M Michels; S de Walque; Wim G J Hol
Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases.
Journal of molecular biology 2000;300(4):697-707.
2000: Véronique Hannaert; H Brinkmann; U Nowitzki; J A Lee; Marie-Astrid Albert; Christoph Wilhelm Sensen; Terry Gaasterland; M Müller; Paul A M Michels; W Martin
Enolase from Trypanosoma brucei, from the amitochondriate protist Mastigamoeba balamuthi, and from the chloroplast and cytosol of Euglena gracilis: pieces in the evolutionary puzzle of the eukaryotic glycolytic pathway.
Molecular biology and evolution 2000;17(7):989-1000.
2000: Stephen Suresh; Stewart Turley; Fred R Opperdoes; Paul A M Michels; Wim G J Hol
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure (London, England : 1993) 2000;8(5):541-52.
2000: I Králová; Daniel J Rigden; Fred R Opperdoes; Paul A M Michels
Glycerol kinase of Trypanosoma brucei. Cloning, molecular characterization and mutagenesis.
European journal of biochemistry / FEBS 2000;267(8):2323-33.
2000: Nathalie Chevalier; Daniel J Rigden; Joris Van Roy; Fred R Opperdoes; Paul A M Michels
Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase.
European journal of biochemistry / FEBS 2000;267(5):1464-72.
2000: Barbara M Bakker; F I Mensonides; Bas Teusink; P van Hoek; Paul A M Michels; Hans V Westerhoff
Compartmentation protects trypanosomes from the dangerous design of glycolysis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2087-92.
2000: S Marché; Paul A M Michels; Fred R Opperdoes
Comparative study of Leishmania mexicana and Trypanosoma brucei NAD-dependent glycerol-3-phosphate dehydrogenase.
Molecular and biochemical parasitology 2000;106(1):83-91.
2000: Barbara M Bakker; Hans V Westerhoff; Fred R Opperdoes; Paul A M Michels
Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.
Molecular and biochemical parasitology 2000;106(1):1-10.
2000: L A Fothergill-Gillmore; Daniel J Rigden; Paul A M Michels; S E Phillips
Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties.
Biochemical Society transactions 2000;28(2):186-90.
1999: S de Walque; J A Kiel; M Veenhuis; Fred R Opperdoes; Paul A M Michels
Cloning and analysis of the PTS-1 receptor in Trypanosoma brucei.
Molecular and biochemical parasitology 1999;104(1):106-19.
1999: A W Zomer; Paul A M Michels; Fred R Opperdoes
Molecular characterisation of Trypanosoma brucei alkyl dihydroxyacetone-phosphate synthase.
Molecular and biochemical parasitology 1999;104(1):55-66.
1999: S de Walque; Fred R Opperdoes; Paul A M Michels
Cloning and characterization of Leishmania mexicana fructose-1,6-bisphosphate aldolase.
Molecular and biochemical parasitology 1999;103(2):279-83.
1999: Barbara M Bakker; Michael C Walsh; B H ter Kuile; F I Mensonides; Paul A M Michels; Fred R Opperdoes; Hans V Westerhoff
Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10098-103.
1999: Daniel J Rigden; Simon E V Phillips; Paul A M Michels; Linda A Fothergill-Gilmore
The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
Journal of molecular biology 1999;291(3):615-35.
1999: Barbara M Bakker; Paul A M Michels; Fred R Opperdoes; Hans V Westerhoff
What controls glycolysis in bloodstream form Trypanosoma brucei?
The Journal of biological chemistry 1999;274(21):14551-9.
1998: Véronique Hannaert; Fred R Opperdoes; Paul A M Michels
Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida.
Journal of molecular evolution 1998;47(6):728-38.
1998: CA Adjé; Fred R Opperdoes; Paul A M Michels
Molecular analysis of phosphoglycerate kinase in Trypanoplasma borreli and the evolution of this enzyme in kinetoplastida.
Gene 1998;217(1-2):91-9.
1998: I Ernest; Mia callens; Antonio D Uttaro; Nathalie Chevalier; Fred R Opperdoes; H Muirhead; Paul A M Michels
Pyruvate kinase of Trypanosoma brucei: overexpression, purification, and functional characterization of wild-type and mutated enzyme.
Protein expression and purification 1998;13(3):373-82.
1998: A W Zomer; S Allert; Nathalie Chevalier; Mia callens; Fred R Opperdoes; Paul A M Michels
Purification and characterisation of the phosphoglycerate kinase isoenzymes of Trypanosoma brucei expressed in Escherichia coli.
Biochimica et biophysica acta 1998;1386(1):179-88.
1998: Dulce H F Souza; Richard C Garratt; Ana Paula U Araújo; B G Guimarães; W D Jesus; Paul A M Michels; Véronique Hannaert; Glaucius Oliva
Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: structure, catalytic mechanism and targeted inhibitor design.
FEBS letters 1998;424(3):131-5.
1998: BE Bernstein; Paul A M Michels; H Kim; Philip H Petra; Wim G J Hol
The importance of dynamic light scattering in obtaining multiple crystal forms of Trypanosoma brucei PGK.
Protein science : a publication of the Protein Society 1998;7(2):504-7.
1997: Paul A M Michels; Nathalie Chevalier; Fred R Opperdoes; Mark H Rider; Daniel J Rigden
The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme.
European journal of biochemistry / FEBS 1997;250(3):698-704.
1997: CA Adjé; Fred R Opperdoes; Paul A M Michels
Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania mexicana mexicana.
Molecular and biochemical parasitology 1997;90(1):155-68.
1997: BE Bernstein; Paul A M Michels; Wim G J Hol
Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation.
Nature 1997;385(6613):275-8.
1996: L Kohl; T Drmota; C D Thi; Mia callens; J Van Beeumen; Fred R Opperdoes; Paul A M Michels
Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli.
Molecular and biochemical parasitology 1996;76(1-2):159-73.
1995: E A Wiemer; Paul A M Michels; Fred R Opperdoes
The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.
The Biochemical journal 1995;312 ( Pt 2)():479-84.
1995: Barbara M Bakker; Hans V Westerhoff; Paul A M Michels
Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei.
Journal of bioenergetics and biomembranes 1995;27(5):513-25.
1995: Véronique Hannaert; Fred R Opperdoes; Paul A M Michels
Glycosomal glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma brucei and Trypanosoma cruzi: expression in Escherichia coli, purification, and characterization of the enzymes.
Protein expression and purification 1995;6(3):244-50.
1995: E A Wiemer; Véronique Hannaert; P R van den IJssel; J Van Roy; Fred R Opperdoes; Paul A M Michels
Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: an evolutionary scenario of subcellular compartmentation in kinetoplastida.
Journal of molecular evolution 1995;40(4):443-54.
1995: Nathalie Chevalier; Mia callens; Paul A M Michels
High-level expression of Trypanosoma brucei fructose-1,6-bisphosphate aldolase in Escherichia coli and purification of the enzyme.
Protein expression and purification 1995;6(1):39-44.
1994: Christophe Verlinde; Mia callens; Serge Van Calenbergh; Arthur Van Aerschot; Piet Herdewijn; Véronique Hannaert; Paul A M Michels; Fred R Opperdoes; Wim G J Hol
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.
Journal of medicinal chemistry 1994;37(21):3605-13.
1994: Véronique Hannaert; Mia callens; Fred R Opperdoes; Paul A M Michels
Purification and characterization of the native and the recombinant Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase.
European journal of biochemistry / FEBS 1994;225(1):143-9.
1994: K Nyame; C D Do-Thi; Fred R Opperdoes; Paul A M Michels
Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana.
Molecular and biochemical parasitology 1994;67(2):269-79.
1994: I Ernest; Fred R Opperdoes; Paul A M Michels
Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli.
Biochemical and biophysical research communications 1994;201(2):727-32.
1994: Paul A M Michels; Véronique Hannaert
The evolution of kinetoplastid glycosomes.
Journal of bioenergetics and biomembranes 1994;26(2):213-9.
1994: Véronique Hannaert; Paul A M Michels
Structure, function, and biogenesis of glycosomes in kinetoplastida.
Journal of bioenergetics and biomembranes 1994;26(2):205-12.
1994: L Kohl; Mia callens; Rik K Wierenga; Fred R Opperdoes; Paul A M Michels
Triose-phosphate isomerase of Leishmania mexicana mexicana. Cloning and characterization of the gene, overexpression in Escherichia coli and analysis of the protein.
European journal of biochemistry / FEBS 1994;220(2):331-8.
1994: I Ernest; Mia callens; Fred R Opperdoes; Paul A M Michels
Pyruvate kinase of Leishmania mexicana mexicana. Cloning and analysis of the gene, overexpression in Escherichia coli and characterization of the enzyme.
Molecular and biochemical parasitology 1994;64(1):43-54.
1993: T V Borchert; K Pratt; JP Zeelen; Mia callens; M E Noble; Fred R Opperdoes; Paul A M Michels; Rik K Wierenga
Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant.
European journal of biochemistry / FEBS 1993;211(3):703-10.
1993: Fred R Opperdoes; Paul A M Michels
The glycosomes of the Kinetoplastida.
Biochimie 1993;75(3-4):231-4.
1992: B H Ter Kuile; E A Wiemer; Paul A M Michels; Fred R Opperdoes
The electrochemical proton gradient in the bloodstream form of Trypanosoma brucei is dependent on the temperature.
Molecular and biochemical parasitology 1992;55(1-2):21-7.
1992: Véronique Hannaert; M Blaauw; L Kohl; S Allert; Fred R Opperdoes; Paul A M Michels
Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana.
Molecular and biochemical parasitology 1992;55(1-2):115-26.
1992: N Bakalara; G Kendall; Paul A M Michels; Fred R Opperdoes
Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcription level.
The EMBO journal 1992;11(10):3808.
1992: E A Wiemer; B H Ter Kuile; Paul A M Michels; Fred R Opperdoes
Pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei is mediated by a facilitated diffusion carrier.
Biochemical and biophysical research communications 1992;184(2):1028-34.
1991: N Bakalara; G Kendall; Paul A M Michels; Fred R Opperdoes
Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcriptional level.
The EMBO journal 1991;10(12):3861-8.
1991: S Allert; I Ernest; A Poliszczak; Fred R Opperdoes; Paul A M Michels
Molecular cloning and analysis of two tandemly linked genes for pyruvate kinase of Trypanosoma brucei.
European journal of biochemistry / FEBS 1991;200(1):19-27.
1991: A M Lambeir; A M Loiseau; D A Kuntz; Frédéric Vellieux; Paul A M Michels; Fred R Opperdoes
The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes.
European journal of biochemistry / FEBS 1991;198(2):429-35.
1991: Paul A M Michels; M Marchand; L Kohl; S Allert; Rik K Wierenga; Fred R Opperdoes
The cytosolic and glycosomal isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei have a distant evolutionary relationship.
European journal of biochemistry / FEBS 1991;198(2):421-8.
1990: Paul A M Michels; Véronique Hannaert; I Ernest; S Allert
Organization, structure and evolutionary aspects of genes in trypanosomes.
Biochemical Society transactions 1990;18(5):727-9.
1990: S Vijayasarathy; I Ernest; J E Itzhaki; D Sherman; M R Mowatt; Paul A M Michels; C E Clayton
The genes encoding fructose bisphosphate aldolase in Trypanosoma brucei are interspersed with unrelated genes.
Nucleic acids research 1990;18(10):2967-75.
1989: Paul A M Michels
The glycosome of trypanosomes: properties and biogenesis of a microbody.
Experimental parasitology 1989;69(3):310-5.
1989: M Marchand; U Kooystra; Rik K Wierenga; A M Lambeir; J Van Beeumen; Fred R Opperdoes; Paul A M Michels
Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme.
European journal of biochemistry / FEBS 1989;184(2):455-64.
1988: M Marchand; A Poliszczak; W C Gibson; Rik K Wierenga; Fred R Opperdoes; Paul A M Michels
Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei.
Molecular and biochemical parasitology 1988;29(1):65-75.
1988: Paul A M Michels
Compartmentation of glycolysis in trypanosomes: a potential target for new trypanocidal drugs.
Biology of the cell / under the auspices of the European Cell Biology Organization 1988;64(2):157-64.
1987: Rik K Wierenga; B Swinkels; Paul A M Michels; K Osinga; O Misset; J Van Beeumen; W C Gibson; J P Postma; Piet Borst; Fred R Opperdoes
Common elements on the surface of glycolytic enzymes from Trypanosoma brucei may serve as topogenic signals for import into glycosomes.
The EMBO journal 1987;6(1):215-21.
1986: Paul A M Michels; A Poliszczak; K A Osinga; O Misset; J Van Beeumen; Rik K Wierenga; Piet Borst; Fred R Opperdoes
Two tandemly linked identical genes code for the glycosomal glyceraldehyde-phosphate dehydrogenase in Trypanosoma brucei.
The EMBO journal 1986;5(5):1049-56.
1986: A Bernards; J M Kooter; Paul A M Michels; R M Moberts; Piet Borst
Pulsed field gradient electrophoresis of DNA digested in agarose allows the sizing of the large duplication unit of a surface antigen gene in trypanosomes.
Gene 1986;42(3):313-22.
1985: K A Osinga; B W Swinkels; W C Gibson; Piet Borst; G H Veeneman; Jacques H van Boom; Paul A M Michels; Fred R Opperdoes
Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei.
The EMBO journal 1985;4(13B):3811-7.
1985: A W Cornelissen; Paul A M Michels; Piet Borst; W Spanjer; J A Versluijs-Broers; C Van der Meer; F Farzaneh; S Shall
Effect of 3-aminobenzamide on antigenic variation of Trypanosoma brucei.
Biochemical pharmacology 1985;34(23):4151-6.
1985: W C Gobson; K A Osinga; Paul A M Michels; Piet Borst
Trypanosomes of subgenus Trypanozoon are diploid for housekeeping genes.
Molecular and biochemical parasitology 1985;16(3):231-42.
1985: A W Cornelissen; G A Bakkeren; J D Barry; Paul A M Michels; Piet Borst
Characteristics of trypanosome variant antigen genes active in the tsetse fly.
Nucleic acids research 1985;13(13):4661-76.
1985: A Y Liu; Paul A M Michels; A Bernards; P Borst
Trypanosome variant surface glycoprotein genes expressed early in infection.
Journal of molecular biology 1985;182(3):383-96.
1984: L H Van der Ploeg; A W Cornelissen; Paul A M Michels; Piet Borst
Chromosome rearrangements in Trypanosoma brucei.
Cell 1984;39(1):213-21.
1984: T De Lange; Paul A M Michels; H J Veerman; A W Cornelissen; Piet Borst
Many trypanosome messenger RNAs share a common 5' terminal sequence.
Nucleic acids research 1984;12(9):3777-90.
1984: A Bernards; T De Lange; Paul A M Michels; A Y Liu; M J Huisman; Piet Borst
Two modes of activation of a single surface antigen gene of Trypanosoma brucei.
Cell 1984;36(1):163-70.
1983: Piet Borst; A Bernards; L H van der Ploeg; Paul A M Michels; A Y Liu; T de Lange; J M Kooter
The control of variant surface antigen synthesis in trypanosomes.
European journal of biochemistry / FEBS 1983;137(3):383-9.
1983: T De Lange; J M Kooter; Paul A M Michels; Piet Borst
Telomere conversion in trypanosomes.
Nucleic acids research 1983;11(23):8149-65.
1983: A Bernards; Paul A M Michels; C R Lincke; P Borst
Growth of chromosome ends in multiplying trypanosomes.
Nature 1983;303(5918):592-7.
1983: Paul A M Michels; A Y Liu; A Bernards; P Sloof; M M Van der Bijl; A H Schinkel; H H Menke; Piet Borst; G H Veeneman; M C Tromp; Jacques H van Boom
Activation of the genes for variant surface glycoproteins 117 and 118 in Trypanosoma brucei.
Journal of molecular biology 1983;166(4):537-56.
1982: L H Van der Ploeg; A Y Liu; Paul A M Michels; T De Lange; Piet Borst; H K Majumder; H Weber; G H Veeneman; Jacques H van Boom
RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes.
Nucleic acids research 1982;10(12):3591-604.
1982: Paul A M Michels; A Bernards; L H Van der Ploeg; P Borst
Characterization of the expression-linked gene copies of variant surface glycoprotein 118 in two independently isolated clones of Trypanosoma brucei.
Nucleic acids research 1982;10(7):2353-66.