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Kathrin Michelsen

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Chemicals & Drugs

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Signal Transduction

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Kathrin S Michelsen; Deepti Dhall; Brian Ko; Lisa S Thomas; Michelle H Wong; Stephan R Targan
HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.
Robert Barrett; Dror Berel; Jyh-Yau Chang; Hon Wai Koon ; Kathrin S Michelsen; Mary Ann Nguyen; Charalabos Pothoulakis; Stephan R Targan; Michelle Vu; Nicole Yeager; Xiaolan Zhang; David Q Shih
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
Pearl Gray; Kathrin S Michelsen; Altan Rentsendorj; Terrence Town; Constantinos Brikos; Timothy R Crother; Jargalsaikhan Dagvadorj; Moshe Arditi
Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.

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All Publications

2013: Kathrin S Michelsen; Deepti Dhall; Brian Ko; Lisa S Thomas; Michelle H Wong; Stephan R Targan
HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.
Inflammatory bowel diseases 2013;19(1):151-64.
2012: Robert Barrett; Dror Berel; Jyh-Yau Chang; Hon Wai Koon ; Kathrin S Michelsen; Mary Ann Nguyen; Charalabos Pothoulakis; Stephan R Targan; Michelle Vu; Nicole Yeager; Xiaolan Zhang; David Q Shih
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
The American journal of pathology 2012;180(2):636-49.
2011: Pearl Gray; Kathrin S Michelsen; Altan Rentsendorj; Terrence Town; Constantinos Brikos; Timothy R Crother; Jargalsaikhan Dagvadorj; Moshe Arditi
Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4331-7.
2011: David Q Shih; Robert Barrett; Xiaolan Zhang; Nicole Yeager; Hon Wai Koon ; Piangwarin Phaosawasdi; Yahui Song; Brian Ko; Michelle H Wong; Kathrin S Michelsen; Gislaine Martins; Charalabos Pothoulakis; Stephan R Targan
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.
PloS one 2011;6(1):e16090.
2011: David Q Shih; Kathrin S Michelsen; Robert J Barrett; Eva Biener-Ramanujan; Rivkah Gonsky; Xiaolan Zhang; Stephan R Targan
Insights into TL1A and IBD pathogenesis.
Advances in experimental medicine and biology 2011;691():279-88.
2010: Pearl Gray; Kathrin S Michelsen; Cherilyn M Sirois; Emily Lowe; Kenichi Shimada; Timothy R Crother; Shuang Chen; Constantinos Brikos; Yonca Bulut; Eicke Latz; David Underhill; Moshe Arditi
Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6359-66.
2010: Antoine Soliman; Kathrin S Michelsen; Hisae Karahashi; Jing Lu; Fan Jing Meng; Xiaowu Qu; Timothy R Crother; Shervin Rabizadeh; Shuang Chen; Michael S Caplan; Moshe Arditi; Tamas Jilling
Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis.
PloS one 2010;5(10):e15044.
2010: Emily L Lowe; Timothy R Crother; Shervin Rabizadeh; Bing Hu; Hanlin Wang; Shuang Chen; Kenichi Shimada; Michelle H Wong; Kathrin S Michelsen; Moshe Arditi
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer.
PloS one 2010;5(9):e13027.
2009: Masayuki Saruta; Kathrin S Michelsen; Lisa S Thomas; Qi T Yu; Carol J Landers; Stephan R Targan
TLR8-mediated activation of human monocytes inhibits TL1A expression.
European journal of immunology 2009;39(8):2195-202.
2009: Hisae Karahashi; Kathrin S Michelsen; Moshe Arditi
Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7280-6.
2009: James F Curtin; Naiyou Liu; Marianela Candolfi; Weidong Xiong; Hikmat Assi; Kader Yagiz; Matthew R Edwards; Kathrin S Michelsen; Kurt M Kroeger; Chunyan Liu; A K M Ghulam Muhammad; Mary C Clark; Moshe Arditi; Begonya Comin-Anduix; Antoni Ribas; Pedro R Lowenstein; Maria G Castro
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine 2009;6(1):e10.
2009: Kathrin S Michelsen; Lisa S Thomas; Kent D Taylor; Qi T Yu; Ling Mei; Carol J Landers; Carrie Derkowski; Dermot P B McGovern; Jerome I Rotter; Stephan R Targan
IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.
PloS one 2009;4(3):e4719.
2008: Yoshikazu Naiki; Rosalinda Sorrentino; Michelle H Wong; Kathrin S Michelsen; Kenichi Shimada; Shuang Chen; Atilla Yilmaz; Anatoly Slepenkin; Nicolas W J Schröder; Timothy R Crother; Yonca Bulut; Terence M Doherty; Michelle Bradley; Zory Shaposhnik; Ellena M Peterson; Peter Tontonoz; Prediman K Shah; Moshe Arditi
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7176-85.
2008: Hidetoshi Takedatsu; Kathrin S Michelsen; Bo Wei; Carol J Landers; Lisa S Thomas; Deepti Dhall; Jonathan Braun; Stephan R Targan
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
Gastroenterology 2008;135(2):552-67.
2007: John L Prehn; Lisa S Thomas; Carol J Landers; Qi T Yu; Kathrin S Michelsen; Stephan R Targan
The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4033-8.
2007: Michelle H Wong; Danica J Schulte; Moshe Arditi; Kathrin S Michelsen
Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells.
Journal of endotoxin research 2007;13(5):281-96.
2007: Kathrin S Michelsen; Moshe Arditi
Toll-like receptors and innate immunity in gut homeostasis and pathology.
Current opinion in hematology 2007;14(1):48-54.
2006: Kathrin S Michelsen; Moshe Arditi
Toll-like receptor signaling and atherosclerosis.
Current opinion in hematology 2006;13(3):163-8.
2006: O Equils; Y Naiki; A M Shapiro; Kathrin S Michelsen; D Lu; J Adams; S Jordan
1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells.
Clinical and experimental immunology 2006;143(1):58-64.
2005: Margalit E Rosenkranz; Danica J Schulte; Lucila M A Agle; Michelle H Wong; Wenxuan Zhang; Lionel B Ivashkiv; Terence M Doherty; Michael C Fishbein; Thomas Lehman; Kathrin S Michelsen; Moshe Arditi
TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease.
Circulation 2005;112(19):2966-73.
2005: Cagla Tükel; Manuela Raffatellu; Andrea D Humphries; R Paul Wilson; Helene Andrews-Polymenis; Tamara Gull; Josely F Figueiredo; Michelle H Wong; Kathrin S Michelsen; Mustafa Akçelik; Garry Adams; Andreas J Baumler
CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2.
Molecular microbiology 2005;58(1):289-304.
2005: Kelly S Doran; Erin J Engelson; Arya Khosravi; Heather C Maisey; Iris Fedtke; Ozlem Equils; Kathrin S Michelsen; Moshe Arditi; Andreas Peschel; Victor Nizet
Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid.
The Journal of clinical investigation 2005;115(9):2499-507.
2005: Nicolas W J Schröder; Isabel Diterich; Antje Zinke; Jana Eckert; Christian Draing; Volker von Baehr; Dieter Hassler; Susanne Priem; Katrin Hahn; Kathrin S Michelsen; Thomas Hartung; Gerd R Burmester; Ulf B Göbel; Corinna Hermann; Ralf R Schumann
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2534-40.
2005: Yoshikazu Naiki; Kathrin S Michelsen; Nicolas W J Schröder; Randa Alsabeh; Anatoly Slepenkin; Wenxuan Zhang; Shuang Chen; Bo Wei; Yonca Bulut; Michelle H Wong; Ellena M Peterson; Moshe Arditi
MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia.
The Journal of biological chemistry 2005;280(32):29242-9.
2005: Yonca Bulut; Kathrin S Michelsen; Linda Hayrapetian; Yoshikazu Naiki; Ralf Spallek; Mahavir Singh; Moshe Arditi
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.
The Journal of biological chemistry 2005;280(22):20961-7.
2005: Masayuki Fukata; Kathrin S Michelsen; Rajaraman Eri; Lisa S Thomas; Bing Hu; Katie Lukasek; Cynthia C Nast; Juan Lechago; Ruliang Xu; Yoshikazu Naiki; Antoine Soliman; Moshe Arditi; Maria Abreu
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(5):G1055-65.
2005: Arnd Lentschat; Hisae Karahashi; Kathrin S Michelsen; Lisa S Thomas; Wenxuan Zhang; Stefanie N Vogel; Moshe Arditi
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4252-61.
2005: Yoshikazu Naiki; Kathrin S Michelsen; Wenxuang Zhang; Shuang Chen; Terence M Doherty; Moshe Arditi
Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.
The Journal of biological chemistry 2005;280(7):5491-5.
2004: Kathrin S Michelsen; Terence M Doherty; Prediman K Shah; Moshe Arditi
Role of Toll-like receptors in atherosclerosis.
Circulation research 2004;95(12):e96-7.
2004: Kathrin S Michelsen; Terence M Doherty; Prediman K Shah; Moshe Arditi
TLR signaling: an emerging bridge from innate immunity to atherogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):5901-7.
2004: Puja Vora; Adrienne Youdim; Lisa S Thomas; Masayuki Fukata; Samuel Y Tesfay; Katie Lukasek; Kathrin S Michelsen; Akihiro Wada; Toshiya Hirayama; Moshe Arditi; Maria Abreu
Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5398-405.
2004: Kathrin S Michelsen; Michelle H Wong; Prediman K Shah; Wenxuan Zhang; Juliana Yano; Terence M Doherty; Shizuo Akira; Tripathi B Rajavashisth; Moshe Arditi
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10679-84.
2004: Ozlem Equils; Zeynep Madak; Chunrin Liu; Kathrin S Michelsen; Yonca Bulut; Daning Lu
Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7642-6.
2003: Ozlem Equils; Marco L Schito; Hisae Karahashi; Zeynep Madak; Ayse Yarali; Kathrin S Michelsen; Alan Sher; Moshe Arditi
Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5159-64.
2003: Gil Y Melmed; Lisa S Thomas; Nahee Lee; Samuel Y Tesfay; Katie Lukasek; Kathrin S Michelsen; Yuehua Zhou; Bing Hu; Moshe Arditi; Maria Abreu
Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1406-15.
2003: Maria Abreu; Lisa S Thomas; Elizabeth T Arnold; Katie Lukasek; Kathrin S Michelsen; Moshe Arditi
TLR signaling at the intestinal epithelial interface.
Journal of endotoxin research 2003;9(5):322-30.
2002: Yonca Bulut; Emmanuelle Faure; Lisa Thomas; Hisae Karahashi; Kathrin S Michelsen; Ozlem Equils; Sandra G Morrison; Richard P Morrison; Moshe Arditi
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1435-40.
2001: Kathrin S Michelsen; Alexandra Aicher; Mariette Mohaupt; Thomas Hartung; Stefanie Dimmeler; Carsten J Kirschning; Ralf R Schumann
The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
The Journal of biological chemistry 2001;276(28):25680-6.
2001: B Opitz; Nicolas W J Schröder; Ingo Spreitzer; Kathrin S Michelsen; Carsten J Kirschning; Werner Hallatschek; Ulrich Zähringer; Thomas Hartung; Ulf B Göbel; Ralf R Schumann
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation.
The Journal of biological chemistry 2001;276(25):22041-7.
2001: Nicolas W J Schröder; Dagmar Pfeil; B Opitz; Kathrin S Michelsen; J Amberger; Ulrich Zähringer; Ulf B Göbel; Ralf R Schumann
Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid.
The Journal of biological chemistry 2001;276(13):9713-9.
2000: Nicolas W J Schröder; B Opitz; Norbert Lamping; Kathrin S Michelsen; Ulrich Zähringer; Ulf B Göbel; Ralf R Schumann
Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2683-93.