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Christine Bear

Research Profile

Chemicals & Drugs

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Cystic Fibrosis

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TOP 3
Christine E Bear
50 years ago in the Journal of Pediatrics: the effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas.
Paul D W Eckford; Canhui Li; Mohabir Ramjeesingh; Christine E Bear
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
Amy P Wong; Tadeo O Thompson; Christine E Bear; Stephanie Chin; James Ellis; Ling-Jun Huan; Peter Pasceri; Felix Ratjen; Janet Rossant
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.

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All Publications

2013: Christine E Bear
50 years ago in the Journal of Pediatrics: the effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas.
The Journal of pediatrics 2013;162(1):85.
2012: Paul D W Eckford; Canhui Li; Mohabir Ramjeesingh; Christine E Bear
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
The Journal of biological chemistry 2012;287(44):36639-49.
2012: Amy P Wong; Tadeo O Thompson; Christine E Bear; Stephanie Chin; James Ellis; Ling-Jun Huan; Peter Pasceri; Felix Ratjen; Janet Rossant
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.
Nature biotechnology 2012;30(9):876-82.
2012: Steven Molinski; Stan Pasyk; Saumel Ahmadi; Stephanie Chin; Paul D W Eckford; Christine E Bear
Functional Rescue of F508del-CFTR Using Small Molecule Correctors.
Frontiers in pharmacology 2012;3():160.
2012: Stan Pasyk; Wilson Yu; Paul D W Eckford; Steven Molinski; Christine E Bear
Identification and validation of hits from high throughput screens for CFTR modulators.
Current pharmaceutical design 2012;18(5):628-41.
2011: Patrick Kim Chiaw; Paul D W Eckford; Christine E Bear
Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.
Essays in biochemistry 2011;50(1):233-48.
2011: John C Whitney; Lynn F Wood; Maria F Amaya; Christine E Bear; Paul D W Eckford; Iain D Hay; Canhui Li; Dennis E Ohman; Bernd H Rehm; Howard Robinson; P Lynne Howell
Structural basis for alginate secretion across the bacterial outer membrane.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13083-8.
2011: Wilson Yu; Patrick Kim Chiaw; Christine E Bear
Probing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant.
The Journal of biological chemistry 2011;286(28):24714-25.
2011: Paul D W Eckford; Christine E Bear
Targeting the regulation of CFTR channels.
The Biochemical journal 2011;435(2):e1-4.
2011: Leigh Wellhauser; Cesar Luna-Chavez; Christina D'Antonio; John Tainer; Christine E Bear
ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
The Journal of biological chemistry 2011;286(8):6733-41.
2010: Patrick Kim Chiaw; Leigh Wellhauser; Ling Jun Huan; Mohabir Ramjeesingh; Christine E Bear
A chemical corrector modifies the channel function of F508del-CFTR.
Molecular pharmacology 2010;78(3):411-8.
2010: Leigh Wellhauser; Christina D'Antonio; Christine E Bear
ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.
Pflügers Archiv : European journal of physiology 2010;460(2):543-57.
2010: Anne-Marie Lamhonwah; Christine E Bear; Ling Jun Huan; Patrick Kim Chiaw; Cameron Ackerley; Ingrid Tein
Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise.
Annals of neurology 2010;67(6):802-8.
2010: M A Cortez; Canhui Li; S N Whitehead; Sonja U Dhani; C D'Antonio; L J Huan; S A L Bennett; O Carter Snead; Christine E Bear
Disruption of ClC-2 expression is associated with progressive neurodegeneration in aging mice.
Neuroscience 2010;167(1):154-62.
2009: Joanne C Cheung; Patrick Kim Chiaw; Charles M Deber; Christine E Bear
A novel method for monitoring the cytosolic delivery of peptide cargo.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):2-7.
2009: Leigh Wellhauser; Patrick Kim Chiaw; Stan Pasyk; Canhui Li; Mohabir Ramjeesingh; Christine E Bear
A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.
Molecular pharmacology 2009;75(6):1430-8.
2009: Raha Mohammad-Panah; Leigh Wellhauser; Benjamin E Steinberg; Yanchun Wang; Ling Jun Huan; Xiang-Dong Liu; Christine E Bear
An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.
Journal of cell science 2009;122(Pt 8):1229-37.
2009: Stan Pasyk; Canhui Li; Mohabir Ramjeesingh; Christine E Bear
Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
The Biochemical journal 2009;418(1):185-90.
2008: Joanne C Cheung; Patrick Kim Chiaw; Stan Pasyk; Christine E Bear
Molecular basis for the ATPase activity of CFTR.
Archives of biochemistry and biophysics 2008;476(1):95-100.
2008: Mohabir Ramjeesingh; Francisca Ugwu; Fiona L L Stratford; Ling-Jun Huan; Canhui Li; Christine E Bear
The intact CFTR protein mediates ATPase rather than adenylate kinase activity.
The Biochemical journal 2008;412(2):315-21.
2008: Jian Payandeh; Canhui Li; Mohabir Ramjeesingh; Ewa Poduch; Christine E Bear; Emil F Pai
Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system.
The Journal of biological chemistry 2008;283(17):11721-33.
2008: Sonja U Dhani; Patrick Kim Chiaw; Ling-Jun Huan; Christine E Bear
ATP depletion inhibits the endocytosis of ClC-2.
Journal of cellular physiology 2008;214(1):273-80.
2007: Fiona L L Stratford; Mohabir Ramjeesingh; Joanne C Cheung; Ling-Jun Huan; Christine E Bear
The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.
The Biochemical journal 2007;401(2):581-6.
2006: Leigh Wellhauser; Hsin-Hen Kuo; Fiona L L Stratford; Mohabir Ramjeesingh; Ling-Jun Huan; Winnie Luong; Canhui Li; Charles M Deber; Christine E Bear
Nucleotides bind to the C-terminus of ClC-5.
The Biochemical journal 2006;398(2):289-94.
2006: Mohabir Ramjeesingh; Canhui Li; Yi-Min She; Christine E Bear
Evaluation of the membrane-spanning domain of ClC-2.
The Biochemical journal 2006;396(3):449-60.
2006: Sonja U Dhani; Christine E Bear
Role of intramolecular and intermolecular interactions in ClC channel and transporter function.
Pflügers Archiv : European journal of physiology 2006;451(6):708-15.
2004: Jackie F Kidd; Mohabir Ramjeesingh; Fiona L L Stratford; Ling-Jun Huan; Christine E Bear
A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity.
The Journal of biological chemistry 2004;279(40):41664-9.
2004: Ilana Kogan; Mohabir Ramjeesingh; Christine E Bear
ATPase assay of purified, reconstituted CFTR protein.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():133-4.
2004: Caroline Norez; Ghanshyam D Heda; Timothy Jensen; Ilana Kogan; Lauren K Hughes; Céline Auzanneau; Renaud Dérand; Laurence Bulteau-Pignoux; Canhui Li; Mohabir Ramjeesingh; Hongyu Li; David N Sheppard; Christine E Bear; John R Riordan; Frédéric Becq
Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():119-21.
2004: David N Sheppard; Mike Gray; Xiandi Gong; Yoshiro Sohma; Ilana Kogan; Dale J Benos; Toby S Scott-Ward; Jeng-Haur Chen; Hongyu Li; Zhiwei Cai; Jyoti Gupta; Canhui Li; Mohabir Ramjeesingh; Bakhrom K Berdiev; Iskander I Ismailov; Christine E Bear; Tzyh-Chang Hwang; Paul Linsdell; Martin J Hug
The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():101-8.
2004: Dale J Benos; Bakhrom K Berdiev; Iskander I Ismailov; Lynda S Ostedgaard; Ilana Kogan; Canhui Li; Mohabir Ramjeesingh; Christine E Bear
Methods to study CFTR protein in vitro.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():79-83.
2004: Vinciane Grimard; Canhui Li; Mohabir Ramjeesingh; Christine E Bear; Erik Goormaghtigh; Jean-Marie Ruysschaert
Phosphorylation-induced conformational changes of cystic fibrosis transmembrane conductance regulator monitored by attenuated total reflection-Fourier transform IR spectroscopy and fluorescence spectroscopy.
The Journal of biological chemistry 2004;279(7):5528-36.
2004: Jackie F Kidd; Ilana Kogan; Christine E Bear
Molecular basis for the chloride channel activity of cystic fibrosis transmembrane conductance regulator and the consequences of disease-causing mutations.
Current topics in developmental biology 2004;60():215-49.
2003: Mohabir Ramjeesingh; Francisca Ugwu; Canhui Li; Sonja U Dhani; Ling-Jun Huan; Yanchun Wang; Christine E Bear
Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.
The Biochemical journal 2003;375(Pt 3):633-41.
2003: Mohabir Ramjeesingh; Jackie F Kidd; Ling-Jun Huan; Yanchun Wang; Christine E Bear
Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane.
The Biochemical journal 2003;374(Pt 3):793-7.
2003: Raha Mohammad-Panah; Rene Harrison; Sonja U Dhani; Cameron Ackerley; Ling-Jun Huan; Yanchun Wang; Christine E Bear
The chloride channel ClC-4 contributes to endosomal acidification and trafficking.
The Journal of biological chemistry 2003;278(31):29267-77.
2003: Sonja U Dhani; Raha Mohammad-Panah; Najma Ahmed; Cameron Ackerley; Mohabir Ramjeesingh; Christine E Bear
Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex.
The Journal of biological chemistry 2003;278(18):16262-70.
2003: Ilana Kogan; Mohabir Ramjeesingh; Canhui Li; Jackie F Kidd; Yanchun Wang; Elaine M Leslie; SUSAN COLE; Christine E Bear
CFTR directly mediates nucleotide-regulated glutathione flux.
The EMBO journal 2003;22(9):1981-9.
2002: Jackie F Kidd; Christine E Bear
Epithelial cell chloride channel activity correlates with improved airway function in cystic fibrosis patients with the major mutant: Delta F508.
Pediatric research 2002;52(5):625-7.
2002: Jie Pan; Christine E Bear; Suzanne M Farragher; Ernest Cutz; Herman Yeger
Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models.
American journal of respiratory cell and molecular biology 2002;27(5):553-60.
2002: Raha Mohammad-Panah; Cameron Ackerley; Johanna M Rommens; Monideepa Choudhury; Yanchun Wang; Christine E Bear
The chloride channel ClC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia.
The Journal of biological chemistry 2002;277(1):566-74.
2002: Ilana Kogan; Mohabir Ramjeesingh; Canhui Li; Christine E Bear
Studies of the molecular basis for cystic fibrosis using purified reconstituted CFTR protein.
Methods in molecular medicine 2002;70():143-57.
2001: Mohabir Ramjeesingh; Canhui Li; Ilana Kogan; Yanchun Wang; Ling-Jun Huan; Christine E Bear
A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator.
Biochemistry 2001;40(35):10700-6.
2001: Herman Yeger; Jie Pan; Xiao Wen Fu; Christine E Bear; Ernest Cutz
Expression of CFTR and Cl(-) conductances in cells of pulmonary neuroepithelial bodies.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L713-21.
2001: Ilana Kogan; Mohabir Ramjeesingh; Ling-Jun Huan; Yanchun Wang; Christine E Bear
Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity.
The Journal of biological chemistry 2001;276(15):11575-81.
2001: Raha Mohammad-Panah; K Gyomorey; Johanna M Rommens; M Choudhury; C Li; Yanchun Wang; Christine E Bear
ClC-2 contributes to native chloride secretion by a human intestinal cell line, Caco-2.
The Journal of biological chemistry 2001;276(11):8306-13.
2001: K Gyömörey; E Garami; K Galley; Johanna M Rommens; Christine E Bear
Non-CFTR chloride channels likely contribute to secretion in the murine small intestine.
Pflügers Archiv : European journal of physiology 2001;443 Suppl 1():S103-6.
2000: N Ahmed; Mohabir Ramjeesingh; S Wong; A Varga; E Garami; Christine E Bear
Chloride channel activity of ClC-2 is modified by the actin cytoskeleton.
The Biochemical journal 2000;352 Pt 3():789-94.
2000: K Gyömörey; Richard Rozmahel; Christine E Bear
Amelioration of intestinal disease severity in cystic fibrosis mice is associated with improved chloride secretory capacity.
Pediatric research 2000;48(6):731-4.
2000: K Gyömörey; Herman Yeger; Cameron Ackerley; E Garami; Christine E Bear
Expression of the chloride channel ClC-2 in the murine small intestine epithelium.
American journal of physiology. Cell physiology 2000;279(6):C1787-94.
2000: Mohabir Ramjeesingh; Canhui Li; Ling-Jun Huan; E Garami; Yanchun Wang; Christine E Bear
Quaternary structure of the chloride channel ClC-2.
Biochemistry 2000;39(45):13838-47.
1999: Mohabir Ramjeesingh; Ling-Jun Huan; E Garami; Christine E Bear
Novel method for evaluation of the oligomeric structure of membrane proteins.
The Biochemical journal 1999;342 ( Pt 1)():119-23.
1999: Mohabir Ramjeesingh; Canhui Li; E Garami; Ling-Jun Huan; K Galley; Yanchun Wang; Christine E Bear
Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator).
Biochemistry 1999;38(5):1463-8.
1999: H Xiong; Canhui Li; E Garami; Yanchun Wang; Mohabir Ramjeesingh; K Galley; Christine E Bear
ClC-2 activation modulates regulatory volume decrease.
The Journal of membrane biology 1999;167(3):215-21.
1999: Mohabir Ramjeesingh; E Garami; K Galley; Canhui Li; Yanchun Wang; Christine E Bear
Purification and reconstitution of epithelial chloride channel cystic fibrosis transmembrane conductance regulator.
Methods in enzymology 1999;294():227-46.
1998: C Li; S Breton; Rebecca Morrison; Carolyn Louise Cannon; francesco emma; Roberto Sanchez-Olea; Christine E Bear; Kevin Strange
Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes.
The Journal of general physiology 1998;112(6):727-36.
1998: Eva A Pasyk; X K Morin; P Zeman; E Garami; K Galley; Ling-Jun Huan; Yanchun Wang; Christine E Bear
A conserved region of the R domain of cystic fibrosis transmembrane conductance regulator is important in processing and function.
The Journal of biological chemistry 1998;273(48):31759-64.
1998: Mohabir Ramjeesingh; Ling-Jun Huan; Michael Wilschanski; Peter Roy Durie; Canhui Li; K Gyomorey; Yanchun Wang; Geraldine Kent; K A Tanswell; Ernest Cutz; Cameron Ackerley; Christine E Bear
Assessment of the efficacy of in vivo CFTR protein replacement therapy in CF mice.
Human gene therapy 1998;9(4):521-8.
1997: Geraldine Kent; R Iles; Christine E Bear; Ling-Jun Huan; U Griesenbach; Colin McKerlie; Helena Frndova; Cameron Ackerley; Diane Gosselin; Danuta Radzioch; Hugh O'Brodovich; L C Tsui; Manuel Buchwald; A Keith Tanswell
Lung disease in mice with cystic fibrosis.
The Journal of clinical investigation 1997;100(12):3060-9.
1997: Christine E Bear; Canhui Li; K Galley; Yanchun Wang; E Garami; Mohabir Ramjeesingh
Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR.
Journal of bioenergetics and biomembranes 1997;29(5):465-73.
1997: Mohabir Ramjeesingh; Canhui Li; E Garami; Ling-Jun Huan; M Hewryk; Yanchun Wang; K Galley; Christine E Bear
A novel procedure for the efficient purification of the cystic fibrosis transmembrane conductance regulator (CFTR).
The Biochemical journal 1997;327 ( Pt 1)():17-21.
1997: Richard Rozmahel; K Gyömörey; S Plyte; Van Nguyen; Michael Wilschanski; Peter Roy Durie; Christine E Bear; Lap-Chee Tsui
Incomplete rescue of cystic fibrosis transmembrane conductance regulator deficient mice by the human CFTR cDNA.
Human molecular genetics 1997;6(7):1153-62.
1996: Canhui Li; Mohabir Ramjeesingh; W Wang; E Garami; M Hewryk; D Lee; Johanna M Rommens; K Galley; Christine E Bear
ATPase activity of the cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 1996;271(45):28463-8.
1996: Canhui Li; Mohabir Ramjeesingh; Christine E Bear
Purified cystic fibrosis transmembrane conductance regulator (CFTR) does not function as an ATP channel.
The Journal of biological chemistry 1996;271(20):11623-6.
1996: Richard Rozmahel; Michael Wilschanski; A Matin; S Plyte; M Oliver; Wojtek Auerbach; A Moore; J Forstner; Peter Roy Durie; J Nadeau; Christine E Bear; Lap-Chee Tsui
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor.
Nature genetics 1996;12(3):280-7.
1996: Michael Wilschanski; Richard Rozmahel; Satti Beharry; Geraldine Kent; Canhui Li; Lap-Chee Tsui; Peter Roy Durie; Christine E Bear
In vivo measurements of ion transport in long-living CF mice.
Biochemical and biophysical research communications 1996;219(3):753-9.
1995: X K Morin; T D Bond; T W Loo; D M Clarke; Christine E Bear
Failure of P-glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling-activated chloride channel activity.
The Journal of physiology 1995;486 ( Pt 3)():707-14.
1995: A J Krolczyk; Christine E Bear; P F Lai; Bernard P Schimmer
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Journal of cellular physiology 1995;162(1):64-73.
1994: Christine E Bear
Drugs transported by P-glycoprotein inhibit a 40 pS outwardly rectifying chloride channel.
Biochemical and biophysical research communications 1994;200(1):513-21.
1993: Gergely L Lukacs; Xiu-Bao Chang; Christine E Bear; Norbert Kartner; A Mohamed; John R Riordan; Sergio Grinstein
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
The Journal of biological chemistry 1993;268(29):21592-8.
1993: Hugh O'Brodovich; X Wang; C Li; Bijan Rafii; J Correa; Christine E Bear
Novobiocin forms cation-permeable ion channels in rat fetal distal lung epithelium.
The American journal of physiology 1993;264(6 Pt 1):C1532-7.
1993: Canhui Li; Mohabir Ramjeesingh; E Reyes; T Jensen; Xiu-Bao Chang; Johanna M Rommens; Christine E Bear
The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR.
Nature genetics 1993;3(4):311-6.
1993: Christine E Bear; V Ling
Multidrug resistance and cystic fibrosis genes: complementarity of function?
Trends in genetics : TIG 1993;9(3):67-8.
1992: R Sood; Christine E Bear; Wojtek Auerbach; E Reyes; T Jensen; Norbert Kartner; John R Riordan; Manuel Buchwald
Regulation of CFTR expression and function during differentiation of intestinal epithelial cells.
The EMBO journal 1992;11(7):2487-94.
1992: Christine E Bear; C H Li; Norbert Kartner; R J Bridges; Timothy J Jensen; Mohabir Ramjeesingh; John R Riordan
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR).
Cell 1992;68(4):809-18.
1992: Christine E Bear; E F Reyes
cAMP-activated chloride conductance in the colonic cell line, Caco-2.
The American journal of physiology 1992;262(1 Pt 1):C251-6.
1991: Christine E Bear; C H Li
Calcium-permeable channels in rat hepatoma cells are activated by extracellular nucleotides.
The American journal of physiology 1991;261(6 Pt 1):C1018-24.
1991: Christine E Bear
A K(+)-selective channel in the colonic carcinoma cell line: CaCo-2 is activated with membrane stretch.
Biochimica et biophysica acta 1991;1069(2):267-72.
1991: Christine E Bear; F Duguay; A L Naismith; Norbert Kartner; John W Hanrahan; John R Riordan
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
The Journal of biological chemistry 1991;266(29):19142-5.
1991: Johanna M Rommens; Sascha E Dho; Christine E Bear; Norbert Kartner; D Kennedy; John R Riordan; Lap-Chee Tsui; J Kevin Foskett
cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7500-4.
1991: Norbert Kartner; John W Hanrahan; Timothy J Jensen; A L Naismith; S Z Sun; Cameron Ackerley; E F Reyes; Lap-Chee Tsui; Johanna M Rommens; Christine E Bear
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance.
Cell 1991;64(4):681-91.
1991: Christine E Bear
Regulation of ion conductance in human skin fibroblasts.
Advances in experimental medicine and biology 1991;290():273-83; discussion 283-5.
1989: A Rothstein; Christine E Bear
Cell volume changes and the activity of the chloride conductance path.
Annals of the New York Academy of Sciences 1989;574():294-308.
1988: Christine E Bear
Phosphorylation-activated chloride channels in human skin fibroblasts.
FEBS letters 1988;237(1-2):145-9.