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Mark Bear

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Physiology

Chemicals & Drugs

Living Beings

Phenomena

Sensory Deprivation

Procedures

Electric Stimulation

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Network (preview)

Co-Publications
Name
12
Kirkwood, Alfredo
11
Philpot, Benjamin
10
Heynen, Arnold
6
Huber, KM
6
Sawtell, Nathaniel
5
Shouval, Harel
5
Huganir, Richard
5
Cooper, Leon
4
Quinlan, EM
3
Rittenhouse, Cynthia
3
Crozier, Robert
3
Frenkel, Mikhail
3
Snyder, Eric
3
SHULER, MARSHALL
3
Paradiso, Michael

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Publications

TOP 3
Wiig Kjesten A; Whitlock Jonathan R; Epstein Mel H; Carpenter Randall L; Bear Mark F
The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation.
Yoon Bong-June; Smith Gordon B; Heynen Arnold J; Neve Rachael L; Bear Mark F
Essential role for a long-term depression mechanism in ocular dominance plasticity.
Coleman J E; Law K; Bear M F
Anatomical origins of ocular dominance in mouse primary visual cortex.

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All Publications

2009: Wiig Kjesten A; Whitlock Jonathan R; Epstein Mel H; Carpenter Randall L; Bear Mark F
The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation.
Neurobiology of learning and memory 2009;92(1):106-13.
2009: Yoon Bong-June; Smith Gordon B; Heynen Arnold J; Neve Rachael L; Bear Mark F
Essential role for a long-term depression mechanism in ocular dominance plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9860-5.
2009: Coleman J E; Law K; Bear M F
Anatomical origins of ocular dominance in mouse primary visual cortex.
Neuroscience 2009;161(2):561-71.
2009: Linden Monica L; Heynen Arnold J; Haslinger Robert H; Bear Mark F
Thalamic activity that drives visual cortical plasticity.
Nature neuroscience 2009;12(4):390-2.
2009: Cho Kathleen K A; Khibnik Lena; Philpot Benjamin D; Bear Mark F
The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5377-82.
2009: Smith Gordon B; Heynen Arnold J; Bear Mark F
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1515):357-67.
2008: Blais Brian S; Frenkel Mikhail Y; Kuindersma Scott R; Muhammad Rahmat; Shouval Harel Z; Cooper Leon N; Bear Mark F
Recovery from monocular deprivation using binocular deprivation.
Journal of neurophysiology 2008;100(4):2217-24.
2008: Liu Cheng-Hang; Heynen Arnold J; Shuler Marshall G Hussain; Bear Mark F
Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex.
Neuron 2008;58(3):340-5.
2008: Dölen Gül; Bear Mark F
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome.
The Journal of physiology 2008;586(6):1503-8.
2008: Hung Albert Y; Futai Kensuke; Sala Carlo; Valtschanoff Juli G; Ryu Jubin; Woodworth Mollie A; Kidd Fleur L; Sung Clifford C; Miyakawa Tsuyoshi; Bear Mark F; Weinberg Richard J; Sheng Morgan
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(7):1697-708.
2008: Bear Mark F; Dölen Gül; Osterweil Emily; Nagarajan Naveen
Fragile X: translation in action.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(1):84-7.
2007: Dölen Gül; Osterweil Emily; Rao B S Shankaranarayana; Smith Gordon B; Auerbach Benjamin D; Chattarji Sumantra; Bear Mark F
Correction of fragile X syndrome in mice.
Neuron 2007;56(6):955-62.
2007: Philpot Benjamin D; Cho Kathleen K A; Bear Mark F
Obligatory role of NR2A for metaplasticity in visual cortex.
Neuron 2007;53(4):495-502.
2007: Crozier Robert A; Wang Yun; Liu Cheng-Hang; Bear Mark F
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1383-8.
2007: Chen Wendy S; Bear Mark F
Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex.
Neuropharmacology 2007;52(1):200-14.
2006: Whitlock Jonathan R; Heynen Arnold J; Shuler Marshall G; Bear Mark F
Learning induces long-term potentiation in the hippocampus.
Science (New York, N.Y.) 2006;313(5790):1093-7.
2006: Frenkel Mikhail Y; Sawtell Nathaniel B; Diogo Antonia Cinira M; Yoon Bongjune; Neve Rachael L; Bear Mark F
Instructive effect of visual experience in mouse visual cortex.
Neuron 2006;51(3):339-49.
2006: Iny Karen; Heynen Arnold J; Sklar Erik; Bear Mark F
Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(28):7368-74.
2006: Rittenhouse Cynthia D; Siegler Beth A; Voelker Courtney C; Shouval Harel Z; Paradiso Michael A; Bear Mark F
Stimulus for rapid ocular dominance plasticity in visual cortex.
Journal of neurophysiology 2006;95(5):2947-50.
2006: Shuler Marshall G; Bear Mark F
Reward timing in the primary visual cortex.
Science (New York, N.Y.) 2006;311(5767):1606-9.
2005: Bear M F
Therapeutic implications of the mGluR theory of fragile X mental retardation.
Genes, brain, and behavior 2005;4(6):393-8.
2005: Snyder Eric M; Colledge Marcie; Crozier Robert A; Chen Wendy S; Scott John D; Bear Mark F
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
The Journal of biological chemistry 2005;280(17):16962-8.
2005: Dölen Gül; Bear Mark F
Courting a cure for fragile X.
Neuron 2005;45(5):642-4.
2004: Frenkel Mikhail Y; Bear Mark F
How monocular deprivation shifts ocular dominance in visual cortex of young mice.
Neuron 2004;44(6):917-23.
2004: Wallace Wes; Bear Mark F
A morphological correlate of synaptic scaling in visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(31):6928-38.
2004: Nahm Walter K; Philpot Benjamin D; Adams Michelle M; Badiavas Evangelos V; Zhou Linda H; Butmarc Janet; Bear Mark F; Falanga Vincent
Significance of N-methyl-D-aspartate (NMDA) receptor-mediated signaling in human keratinocytes.
Journal of cellular physiology 2004;200(2):309-17.
2004: Bear Mark F; Huber Kimberly M; Warren Stephen T
The mGluR theory of fragile X mental retardation.
Trends in neurosciences 2004;27(7):370-7.
2004: Gallagher Sean M; Daly Christine A; Bear Mark F; Huber Kimberly M
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4859-64.
2003: Colledge Marcie; Snyder Eric M; Crozier Robert A; Soderling Jacquelyn A; Jin Yetao; Langeberg Lorene K; Lu Hua; Bear Mark F; Scott John D
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Neuron 2003;40(3):595-607.
2003: Heynen Arnold J; Yoon Bong-June; Liu Cheng-Hang; Chung Hee J; Huganir Richard L; Bear Mark F
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation.
Nature neuroscience 2003;6(8):854-62.
2003: Philpot Benjamin D; Espinosa Juan S; Bear Mark F
Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5583-8.
2003: Sawtell Nathaniel B; Frenkel Mikhail Y; Philpot Benjamin D; Nakazawa Kazu; Tonegawa Susumu; Bear Mark F
NMDA receptor-dependent ocular dominance plasticity in adult visual cortex.
Neuron 2003;38(6):977-85.
2003: Bear Mark F
Bidirectional synaptic plasticity: from theory to reality.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1432):649-55.
2002: Shouval Harel Z; Bear Mark F; Cooper Leon N
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10831-6.
2002: Huber Kimberly M; Gallagher Sean M; Warren Stephen T; Bear Mark F
Altered synaptic plasticity in a mouse model of fragile X mental retardation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7746-50.
2002: Philpot Benjamin D; Bear Mark F
Synaptic plasticity in an altered state.
Neuron 2002;33(5):665-7.
2001: Heynen A J; Bear M F
Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9801-13.
2001: Wells D G; Dong X; Quinlan E M; Huang Y S; Bear M F; Richter J D; Fallon J R
A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9541-8.
2001: Zeng H; Chattarji S; Barbarosie M; Rondi-Reig L; Philpot B D; Miyakawa T; Bear M F; Tonegawa S
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory.
Cell 2001;107(5):617-29.
2001: Snyder E M; Philpot B D; Huber K M; Dong X; Fallon J R; Bear M F
Internalization of ionotropic glutamate receptors in response to mGluR activation.
Nature neuroscience 2001;4(11):1079-85.
2001: Philpot B D; Weisberg M P; Ramos M S; Sawtell N B; Tang Y P; Tsien J Z; Bear M F
Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex.
Neuropharmacology 2001;41(6):762-70.
2001: Rozas C; Frank H; Heynen A J; Morales B; Bear M F; Kirkwood A
Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(17):6791-801.
2001: Huber K M; Roder J C; Bear M F
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
Journal of neurophysiology 2001;86(1):321-5.
2001: Hannan A J; Blakemore C; Katsnelson A; Vitalis T; Huber K M; Bear M; Roder J; Kim D; Shin H S; Kind P C
PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.
Nature neuroscience 2001;4(3):282-8.
2001: Philpot B D; Sekhar A K; Shouval H Z; Bear M F
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex.
Neuron 2001;29(1):157-69.
2000: Heynen A J; Quinlan E M; Bae D C; Bear M F
Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo.
Neuron 2000;28(2):527-36.
2000: Lee H K; Barbarosie M; Kameyama K; Bear M F; Huganir R L
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity.
Nature 2000;405(6789):955-9.
2000: Huber K M; Kayser M S; Bear M F
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Science (New York, N.Y.) 2000;288(5469):1254-7.
1999: Sawtell N B; Huber K M; Roder J C; Bear M F
Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors.
Journal of neurophysiology 1999;82(6):3594-7.
1999: Quinlan E M; Olstein D H; Bear M F
Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12876-80.
1999: Bear M F; Rittenhouse C D
Molecular basis for induction of ocular dominance plasticity.
Journal of neurobiology 1999;41(1):83-91.
1999: Huang Z J; Kirkwood A; Pizzorusso T; Porciatti V; Morales B; Bear M F; Maffei L; Tonegawa S
BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.
Cell 1999;98(6):739-55.
1999: Bear M F
Homosynaptic long-term depression: a mechanism for memory?
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9457-8.
1999: Quinlan E M; Philpot B D; Huganir R L; Bear M F
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo.
Nature neuroscience 1999;2(4):352-7.
1999: Kirkwood A; Rozas C; Kirkwood J; Perez F; Bear M F
Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(5):1599-609.
1999: Rittenhouse C D; Shouval H Z; Paradiso M A; Bear M F
Monocular deprivation induces homosynaptic long-term depression in visual cortex.
Nature 1999;397(6717):347-50.
1998: Kameyama K; Lee H K; Bear M F; Huganir R L
Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression.
Neuron 1998;21(5):1163-75.
1998: Lee H K; Kameyama K; Huganir R L; Bear M F
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus.
Neuron 1998;21(5):1151-62.
1998: Huber K M; Sawtell N B; Bear M F
Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex.
Neuropharmacology 1998;37(4-5):571-9.
1998: Huber K M; Sawtell N B; Bear M F
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):1-9.
1997: Kirkwood A; Silva A; Bear M F
Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3380-3.
1996: Wiig K A; Cooper L N; Bear M F
Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat.
Learning & memory (Cold Spring Harbor, N.Y.) 1996;3(4):313-25.
1996: Bear M F
A synaptic basis for memory storage in the cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13453-9.
1996: Aizenman C D; Kirkwood A; Bear M F
A current source density analysis of evoked responses in slices of adult rat visual cortex: implications for the regulation of long-term potentiation.
Cerebral cortex (New York, N.Y. : 1991) 1996;6(6):751-8.
1996: Kirkwood A; Rioult M C; Bear M F
Experience-dependent modification of synaptic plasticity in visual cortex.
Nature 1996;381(6582):526-8.
1996: Heynen A J; Abraham W C; Bear M F
Bidirectional modification of CA1 synapses in the adult hippocampus in vivo.
Nature 1996;381(6578):163-6.
1996: Bear M F
NMDA-receptor-dependent synaptic plasticity in the visual cortex.
Progress in brain research 1996;108():205-18.
1996: Bear M F; Abraham W C
Long-term depression in hippocampus.
Annual review of neuroscience 1996;19():437-62.
1995: Bear M F
Mechanism for a sliding synaptic modification threshold.
Neuron 1995;15(1):1-4.
1995: Kirkwood A; Lee H K; Bear M F
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience.
Nature 1995;375(6529):328-31.
1995: Kirkwood A; Bear M F
Elementary forms of synaptic plasticity in the visual cortex.
Biological research 1995;28(1):73-80.
1994: Bear M F; Malenka R C
Synaptic plasticity: LTP and LTD.
Current opinion in neurobiology 1994;4(3):389-99.
1994: Kirkwood A; Bear M F
Homosynaptic long-term depression in the visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 2):3404-12.
1994: Gold J I; Bear M F
A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3941-5.
1994: Kirkwood A; Bear M F
Hebbian synapses in visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(3 Pt 2):1634-45.
1994: Law C C; Bear M F; Cooper L N
Role of the visual environment in the formation of receptive fields according to the BCM theory.
Progress in brain research 1994;102():287-301.
1993: Dudek S M; Bear M F
Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):2910-8.
1993: Kirkwood A; Dudek S M; Gold J T; Aizenman C D; Bear M F
Common forms of synaptic plasticity in the hippocampus and neocortex in vitro.
Science (New York, N.Y.) 1993;260(5113):1518-21.
1993: Bear M F; Kirkwood A
Neocortical long-term potentiation.
Current opinion in neurobiology 1993;3(2):197-202.
1992: Bohner A P; Dudek S M; Bear M F
Effects of N-methyl-D-aspartate on quisqualate-stimulated phosphoinositide hydrolysis in slices of kitten striate cortex.
Brain research 1992;594(1):146-9.
1992: Dudek S M; Bear M F
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4363-7.
1992: Bear M F; Press W A; Connors B W
Long-term potentiation in slices of kitten visual cortex and the effects of NMDA receptor blockade.
Journal of neurophysiology 1992;67(4):841-51.
1991: Clothiaux E E; Bear M F; Cooper L N
Synaptic plasticity in visual cortex: comparison of theory with experiment.
Journal of neurophysiology 1991;66(5):1785-804.
1991: Bear M F; Dudek S M
Stimulation of phosphoinositide turnover by excitatory amino acids. Pharmacology, development, and role in visual cortical plasticity.
Annals of the New York Academy of Sciences 1991;627():42-56.
1990: Bear M F; Colman H
Binocular competition in the control of geniculate cell size depends upon visual cortical N-methyl-D-aspartate receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9246-9.
1990: Barstad K E; Bear M F
Basal forebrain projections to somatosensory cortex in the cat.
Journal of neurophysiology 1990;64(4):1223-32.
1990: Feldman D; Sherin J E; Press W A; Bear M F
N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;80(2):252-9.
1989: Dudek S M; Bear M F
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Science (New York, N.Y.) 1989;246(4930):673-5.
1989: Dudek S M; Bowen W D; Bear M F
Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes.
Brain research. Developmental brain research 1989;47(1):123-8.
1987: Bear M F; Cooper L N; Ebner F F
A physiological basis for a theory of synapse modification.
Science (New York, N.Y.) 1987;237(4810):42-8.
1985: Bear M F; Carnes K M; Ebner F F
Postnatal changes in the distribution of acetylcholinesterase in kitten striate cortex.
The Journal of comparative neurology 1985;237(4):519-32.
1985: Bear M F; Schmechel D E; Ebner F F
Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(5):1262-75.
1985: Bear M F; Carnes K M; Ebner F F
An investigation of cholinergic circuitry in cat striate cortex using acetylcholinesterase histochemistry.
The Journal of comparative neurology 1985;234(4):411-30.
1985: Höhmann C F; Bear M F; Ebner F F
Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain.
Brain research 1985;333(1):165-8.
1983: Bear M F; Ebner F F
Somatostatin-like immunoreactivity in the forebrain of Pseudemys turtles.
Neuroscience 1983;9(2):297-307.
1983: Bear M F; Paradiso M A; Schwartz M; Nelson S B; Carnes K M; Daniels J D
Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity.
Nature 1983;302(5905):245-7.
1983: Bear M F; Daniels J D
The plastic response to monocular deprivation persists in kitten visual cortex after chronic depletion of norepinephrine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(2):407-16.

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