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Russell Middaugh

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Protein Folding

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Amino Acid Sequence

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Co-Publications
Name
20
Volkin, David
15
Burke, Carl
15
Joshi, Sangeeta
13
Koe, Gary
10
Ausar, Salvador
10
Wiethoff, Christopher
9
Picking, William
9
Picking, Wendy
8
Koe, Janet
8
Kueltzo, Lisa
8
Lewis, Randolph
7
Lobo, Brian
7
Kamerzell, Tim
7
Peek, Laura
6
Rexroad, Jason

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Publications

TOP 3
Markham Aaron P; Jaafar Zane A; Kemege Kyle E; Middaugh C Russell; Hefty P Scott
Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein.
Trivedi Maulik; Davis R Andrew; Shabaik Yumna; Roy Ambrish; Verkhivker Gennady; Laurence Jennifer S; Middaugh C Russell; Siahaan Teruna J
The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin.
Cai Sumin; He Feng; Samra Hardeep S; de la Maza Luis M; Bottazzi Maria E; Joshi Sangeeta B; Middaugh C Russell
Biophysical and stabilization studies of the chlamydia trachomatis mouse pneumonitis major outer membrane protein.

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All Publications

2009: Markham Aaron P; Jaafar Zane A; Kemege Kyle E; Middaugh C Russell; Hefty P Scott
Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein.
Biochemistry 2009;48(43):10353-61.
2009: Trivedi Maulik; Davis R Andrew; Shabaik Yumna; Roy Ambrish; Verkhivker Gennady; Laurence Jennifer S; Middaugh C Russell; Siahaan Teruna J
The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin.
Journal of pharmaceutical sciences 2009;98(10):3562-74.
2009: Cai Sumin; He Feng; Samra Hardeep S; de la Maza Luis M; Bottazzi Maria E; Joshi Sangeeta B; Middaugh C Russell
Biophysical and stabilization studies of the chlamydia trachomatis mouse pneumonitis major outer membrane protein.
Molecular pharmaceutics 2009;6(5):1553-61.
2009: He Feng; Joshi Sangeeta B; Bosman Fons; Verhaeghe Marijke; Middaugh C Russell
Structural stability of hepatitis C virus envelope glycoprotein E1: effect of pH and dissociative detergents.
Journal of pharmaceutical sciences 2009;98(9):3340-57.
2009: Ramsey Joshua D; Gill Michelle L; Kamerzell Tim J; Price E Shane; Joshi Sangeeta B; Bishop Steven M; Oliver Cynthia N; Middaugh C Russell
Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability.
Journal of pharmaceutical sciences 2009;98(7):2432-47.
2009: Zeng Yuhong; Fan Haihong; Chiueh Gary; Pham Binh; Martin Russ; Lechuga-Ballesteros David; Truong Vu L; Joshi Sangeeta B; Middaugh C Russell
Towards development of stable formulations of a live attenuated bacterial vaccine: a preformulation study facilitated by a biophysical approach.
Human vaccines 2009;5(5):322-31.
2009: Carpenter John F; Randolph Theodore W; Jiskoot Wim; Crommelin Daan J A; Middaugh C Russell; Winter Gerhard; Fan Ying-Xin; Kirshner Susan; Verthelyi Daniela; Kozlowski Steven; Clouse Kathleen A; Swann Patrick G; Rosenberg Amy; Cherney Barry
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.
Journal of pharmaceutical sciences 2009;98(4):1201-5.
2009: Esfandiary Reza; Kickhoefer Valerie A; Rome Leonard H; Joshi Sangeeta B; Middaugh C Russell
Structural stability of vault particles.
Journal of pharmaceutical sciences 2009;98(4):1376-86.
2009: Zheng Kai; Middaugh C Russell; Siahaan Teruna J
Evaluation of the physical stability of the EC5 domain of E-cadherin: effects of pH, temperature, ionic strength, and disulfide bonds.
Journal of pharmaceutical sciences 2009;98(1):63-73.
2008: Barrett Brooke S; Picking Wendy L; Picking William D; Middaugh C Russell
The response of type three secretion system needle proteins MxiHDelta5, BsaLDelta5, and PrgIDelta5 to temperature and pH.
Proteins 2008;73(3):632-43.
2008: Kissmann Julian; Ausar Salvador F; Foubert Thomas R; Brock Julie; Switzer Mary H; Detzi Edward J; Vedvick Thomas S; Middaugh C Russell
Physical stabilization of Norwalk virus-like particles.
Journal of pharmaceutical sciences 2008;97(10):4208-18.
2008: Salnikova Maya S; Joshi Sangeeta B; Rytting J Howard; Warny Michel; Middaugh C Russell
Preformulation studies of Clostridium difficile toxoids A and B.
Journal of pharmaceutical sciences 2008;97(10):4194-207.
2008: Kissmann Julian; Ausar Salvador F; Rudolph Angela; Braun Chad; Cape Stephen P; Sievers Robert E; Federspiel Mark J; Joshi Sangeeta B; Middaugh C Russell
Stabilization of measles virus for vaccine formulation.
Human vaccines 2008;4(5):350-9.
2008: Salnikova Maya S; Joshi Sangeeta B; Rytting J Howard; Warny Michel; Middaugh C Russell
Physical characterization of clostridium difficile toxins and toxoids: effect of the formaldehyde crosslinking on thermal stability.
Journal of pharmaceutical sciences 2008;97(9):3735-52.
2008: Kamerzell Tim J; Middaugh C Russell
The complex inter-relationships between protein flexibility and stability.
Journal of pharmaceutical sciences 2008;97(9):3494-517.
2008: Nonoyama Akihisa; Laurence Jennifer S; Garriques Liza; Qi Hong; Le Thao; Middaugh C Russell
A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams.
Journal of pharmaceutical sciences 2008;97(7):2552-67.
2008: Brooks Amanda E; Stricker Shane M; Joshi Sangeeta B; Kamerzell Timothy J; Middaugh C Russell; Lewis Randolph V
Properties of synthetic spider silk fibers based on Argiope aurantia MaSp2.
Biomacromolecules 2008;9(6):1506-10.
2008: Salnikova Maya S; Middaugh C Russell; Rytting J Howard
Stability of lyophilized human growth hormone.
International journal of pharmaceutics 2008;358(1-2):108-13.
2008: Markham Aaron P; Birket Susan E; Picking William D; Picking Wendy L; Middaugh C Russell
pH sensitivity of type III secretion system tip proteins.
Proteins 2008;71(4):1830-42.
2008: Peek Laura J; Middaugh C Russell; Berkland Cory
Nanotechnology in vaccine delivery.
Advanced drug delivery reviews 2008;60(8):915-28.
2008: Li Qing-Shan; Cai Sumin; Fang Jianwen; Borchardt Ronald T; Kuczera Krzysztof; Middaugh C Russell; Schowen Richard L
Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
Biochemistry 2008;47(17):4983-91.
2008: Joshi Sangeeta B; Kamerzell Tim J; McNown Chris; Middaugh C Russell
The interaction of heparin/polyanions with bovine, porcine, and human growth hormone.
Journal of pharmaceutical sciences 2008;97(4):1368-85.
2008: Kamerzell Tim J; Ramsey Joshua D; Middaugh C Russell
Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability.
The journal of physical chemistry. B 2008;112(10):3240-50.
2008: Ausar Salvador F; Joshi Sangeeta B; Middaugh C Russell
Spectroscopic methods for the physical characterization and formulation of nonviral gene delivery systems.
Methods in molecular biology (Clifton, N.J.) 2008;434():55-80.
2007: Thyagarajapuram Nagarajan; Olsen David; Middaugh C Russell
Stabilization of proteins by recombinant human gelatins.
Journal of pharmaceutical sciences 2007;96(12):3304-15.
2007: Thyagarajapuram Nagarajan; Olsen David; Middaugh C Russell
The structure, stability, and complex behavior of recombinant human gelatins.
Journal of pharmaceutical sciences 2007;96(12):3363-78.
2007: Middaugh C Russell; Ramsey Joshua D
Analysis of cationic-lipid-plasmid-DNA complexes.
Analytical chemistry 2007;79(19):7240-8.
2007: Kamerzell Tim J; Middaugh C Russell
Two-dimensional correlation spectroscopy reveals coupled immunoglobulin regions of differential flexibility that influence stability.
Biochemistry 2007;46(34):9762-73.
2007: Birket Susan E; Harrington Amanda T; Espina Marianela; Smith Nathan D; Terry Christina M; Darboe Numukunda; Markham Aaron P; Middaugh C Russell; Picking Wendy L; Picking William D
Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri.
Biochemistry 2007;46(27):8128-37.
2007: Brandau Duane T; Joshi Sangeeta B; Smalter Aaron M; Kim Seonyoung; Steadman Bryan; Middaugh C Russell
Stability of the Clostridium botulinum type A neurotoxin complex: an empirical phase diagram based approach.
Molecular pharmaceutics 2007;4(4):571-82.
2007: Kamerzell Tim J; Joshi Sangeeta B; McClean Donald; Peplinskie Lori; Toney Karen; Papac Damon; Li Meili; Middaugh C Russell
Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification.
Protein science : a publication of the Protein Society 2007;16(6):1193-203.
2007: Fan Haihong; Li Huaina; Zhang Mingyu; Middaugh C Russell
Effects of solutes on empirical phase diagrams of human fibroblast growth factor 1.
Journal of pharmaceutical sciences 2007;96(6):1490-503.
2007: Li Qing-Shan; Cai Sumin; Borchardt Ronald T; Fang Jianwen; Kuczera Krzysztof; Middaugh C Russell; Schowen Richard L
Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes.
Biochemistry 2007;46(19):5798-809.
2007: Ausar Salvador F; Espina Marianela; Brock Julie; Thyagarayapuran Nagarajan; Repetto Robert; Khandke Lakshmi; Middaugh C Russell
High-throughput screening of stabilizers for respiratory syncytial virus: identification of stabilizers and their effects on the conformational thermostability of viral particles.
Human vaccines 2007;3(3):94-103.
2007: Espina Marianela; Ausar S Fernando; Middaugh C Russell; Baxter M Aaron; Picking William D; Picking Wendy L
Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems.
Protein science : a publication of the Protein Society 2007;16(4):704-14.
2007: Salamat-Miller Nazila; Fang Jianwen; Seidel Christopher W; Assenov Yassen; Albrecht Mario; Middaugh C Russell
A network-based analysis of polyanion-binding proteins utilizing human protein arrays.
The Journal of biological chemistry 2007;282(14):10153-63.
2007: Tian Fei; Middaugh C Russell; Offerdahl Tom; Munson Eric; Sane Samir; Rytting J Howard
Spectroscopic evaluation of the stabilization of humanized monoclonal antibodies in amino acid formulations.
International journal of pharmaceutics 2007;335(1-2):20-31.
2007: Derrick Tiffany; Grillo Adeola O; Vitharana Samadhi N; Jones Latoya; Rexroad Jason; Shah Ambarish; Perkins Melissa; Spitznagel Thomas M; Middaugh C Russell
Effect of polyanions on the structure and stability of repifermin (keratinocyte growth factor-2).
Journal of pharmaceutical sciences 2007;96(4):761-76.
2007: Fan Haihong; Vitharana Samadhi N; Chen Tracy; O'Keefe Donald; Middaugh C Russell
Effects of pH and polyanions on the thermal stability of fibroblast growth factor 20.
Molecular pharmaceutics 2007;4(2):232-40.
2007: Priddy Timothy S; Middaugh C Russell; Carlson Gerald M
Electrostatic changes in phosphorylase kinase induced by its obligatory allosteric activator Ca2+.
Protein science : a publication of the Protein Society 2007;16(3):517-27.
2007: Harn N; Allan C; Oliver C; Middaugh C R
Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability.
Journal of pharmaceutical sciences 2007;96(3):532-46.
2007: Peek Laura J; Martin Talia T; Elk Nation Charity; Pegram Shannel A; Middaugh C Russell
Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants.
Journal of pharmaceutical sciences 2007;96(3):547-57.
2007: Peek Laura J; Brey Robert N; Middaugh C Russell
A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine.
Journal of pharmaceutical sciences 2007;96(1):44-60.
2006: Kamerzell Tim J; Unruh Jay R; Johnson Carey K; Middaugh C Russell
Conformational flexibility, hydration and state parameter fluctuations of fibroblast growth factor-10: effects of ligand binding.
Biochemistry 2006;45(51):15288-300.
2006: Salamat-Miller Nazila; Fang Jianwen; Seidel Christopher W; Smalter Aaron M; Assenov Yassen; Albrecht Mario; Middaugh C Russell
A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays.
Molecular & cellular proteomics : MCP 2006;5(12):2263-78.
2006: Lucas Laura H; Ersoy Baran A; Kueltzo Lisa A; Joshi Sangeeta B; Brandau Duane T; Thyagarajapuram Nagarajan; Peek Laura J; Middaugh C Russell
Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions.
Protein science : a publication of the Protein Society 2006;15(10):2228-43.
2006: Ruponen Marika; Braun Chad S; Middaugh C Russell
Biophysical characterization of polymeric and liposomal gene delivery systems using empirical phase diagrams.
Journal of pharmaceutical sciences 2006;95(10):2101-14.
2006: Espina Marianela; Ausar S Fernando; Middaugh C Russell; Picking William D; Picking Wendy L
Spectroscopic and calorimetric analyses of invasion plasmid antigen D (IpaD) from Shigella flexneri reveal the presence of two structural domains.
Biochemistry 2006;45(30):9219-27.
2006: Espina Marianela; Olive Andrew J; Kenjale Roma; Moore David S; Ausar S Fernando; Kaminski Robert W; Oaks Edwin V; Middaugh C Russell; Picking William D; Picking Wendy L
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.
Infection and immunity 2006;74(8):4391-400.
2006: Guo Jianxin; Harn Nicholas; Robbins Aaron; Dougherty Ron; Middaugh C Russell
Stability of helix-rich proteins at high concentrations.
Biochemistry 2006;45(28):8686-96.
2006: Peek Laura J; Brandau Duane T; Jones LaToya S; Joshi Sangeeta B; Middaugh C Russell
A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine.
Vaccine 2006;24(31-32):5839-51.
2006: Rexroad Jason; Martin Talia T; McNeilly David; Godwin Simon; Middaugh C Russell
Thermal stability of adenovirus type 2 as a function of pH.
Journal of pharmaceutical sciences 2006;95(7):1469-79.
2006: Ausar Salvador F; Foubert Thomas R; Hudson Mary H; Vedvick Thomas S; Middaugh C Russell
Conformational stability and disassembly of Norwalk virus-like particles. Effect of pH and temperature.
The Journal of biological chemistry 2006;281(28):19478-88.
2006: Darboe Numukunda; Kenjale Roma; Picking Wendy L; Picking William D; Middaugh C Russell
Physical characterization of MxiH and PrgI, the needle component of the type III secretion apparatus from Shigella and Salmonella.
Protein science : a publication of the Protein Society 2006;15(3):543-52.
2006: Fan Haihong; Kashi Ramesh S; Middaugh C Russell
Conformational lability of two molecular chaperones Hsc70 and gp96: effects of pH and temperature.
Archives of biochemistry and biophysics 2006;447(1):34-45.
2006: Purohit Vivek S; Middaugh C Russell; Balasubramanian Sathyamangalam V
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice.
Journal of pharmaceutical sciences 2006;95(2):358-71.
2006: Rexroad Jason; Evans Robert K; Middaugh C Russell
Effect of pH and ionic strength on the physical stability of adenovirus type 5.
Journal of pharmaceutical sciences 2006;95(2):237-47.
2006: Harrington Amanda; Darboe Numukunda; Kenjale Roma; Picking Wendy L; Middaugh C Russell; Birket Susan; Picking William D
Characterization of the interaction of single tryptophan containing mutants of IpaC from Shigella flexneri with phospholipid membranes.
Biochemistry 2006;45(2):626-36.
2006: Jiang Ge; Joshi Sangeeta B; Peek Laura J; Brandau Duane T; Huang Juan; Ferriter Matthew S; Woodley Wendy D; Ford Brandi M; Mar Kevin D; Mikszta John A; Hwang C Robin; Ulrich Robert; Harvey Noel G; Middaugh C Russell; Sullivan Vincent J
Anthrax vaccine powder formulations for nasal mucosal delivery.
Journal of pharmaceutical sciences 2006;95(1):80-96.
2005: Tumanova Irina; Boyer Jean; Ausar S Fernando; Burzynski Joseph; Rosencrance Dana; White Julie; Scheidel Jason; Parkinson Rose; Maguire Henry; Middaugh C Russell; Weiner David; Green Anthony P
Analytical and biological characterization of supercoiled plasmids purified by various chromatographic techniques.
DNA and cell biology 2005;24(12):819-31.
2005: Krogmeier Stephanie L; Reddy D Srinivasa; Vander Velde David; Lushington Gerald H; Siahaan Teruna J; Middaugh C Russell; Borchardt Ronald T; Topp Elizabeth M
Deamidation of model beta-turn cyclic peptides in the solid state.
Journal of pharmaceutical sciences 2005;94(12):2616-31.
2005: Ausar Salvador F; Rexroad Jason; Frolov Vladimir G; Look Jee L; Konar Nandini; Middaugh C Russell
Analysis of the thermal and pH stability of human respiratory syncytial virus.
Molecular pharmaceutics 2005;2(6):491-9.
2005: Harn Nicholas R; Jeng Yunhua N; Kostelc James G; Middaugh C Russell
Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil.
Journal of pharmaceutical sciences 2005;94(11):2487-95.
2005: Fan Haihong; Ralston John; Dibiase Mary; Faulkner Eric; Middaugh C Russell
Solution behavior of IFN-beta-1a: an empirical phase diagram based approach.
Journal of pharmaceutical sciences 2005;94(9):1893-911.
2005: Ramani Karthik; Purohit Vivek; Middaugh C Russell; Balasubramanian Sathyamangalam V
Aggregation kinetics of recombinant human FVIII (rFVIII).
Journal of pharmaceutical sciences 2005;94(9):2023-9.
2005: Ramani Karthik; Purohit Vivek S; Miclea Razvan D; Middaugh C Russell; Balasubramanian Sathyamangalam V
Lipid binding region (2303-2332) is involved in aggregation of recombinant human FVIII (rFVIII).
Journal of pharmaceutical sciences 2005;94(6):1288-99.
2005: Braun Chad S; Fisher Mark T; Tomalia Donald A; Koe Gary S; Koe Janet G; Middaugh C Russell
A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes.
Biophysical journal 2005;88(6):4146-58.
2005: Jones Latoya S; Kaufmann Allyn; Middaugh C Russell
Silicone oil induced aggregation of proteins.
Journal of pharmaceutical sciences 2005;94(4):918-27.
2005: Jones LaToya S; Peek Laura J; Power Jonathan; Markham Aaron; Yazzie Brian; Middaugh C Russell
Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens.
The Journal of biological chemistry 2005;280(14):13406-14.
2005: Braun Chad S; Vetro Joseph A; Tomalia Donald A; Koe Gary S; Koe Janet G; Middaugh C Russell
Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles.
Journal of pharmaceutical sciences 2005;94(2):423-36.
2004: Derrick Tiffany S; Kashi Ramesh S; Durrani Manzer; Jhingan Ashish; Middaugh C Russell
Effect of metal cations on the conformation and inactivation of recombinant human factor VIII.
Journal of pharmaceutical sciences 2004;93(10):2549-57.
2004: Jones LaToya S; Yazzie Brian; Middaugh C Russell
Polyanions and the proteome.
Molecular & cellular proteomics : MCP 2004;3(8):746-69.
2004: Stotz C E; Borchardt R T; Middaugh C R; Siahaan T J; Vander Velde D; Topp E M
Secondary structure of a dynamic type I'beta-hairpin peptide.
The journal of peptide research : official journal of the American Peptide Society 2004;63(4):371-82.
2004: Wiethoff Christopher M; Koe Janet G; Koe Gary S; Middaugh C Russell
Compositional effects of cationic lipid/DNA delivery systems on transgene expression in cell culture.
Journal of pharmaceutical sciences 2004;93(1):108-23.
2003: Lobo Brian A; Vetro Joseph A; Suich Daniel M; Zuckermann Ronald N; Middaugh C Russell
Structure/function analysis of peptoid/lipitoid:DNA complexes.
Journal of pharmaceutical sciences 2003;92(9):1905-18.
2003: Kueltzo Lisa A; Ersoy Baran; Ralston John P; Middaugh C Russell
Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: a bGCSF case study.
Journal of pharmaceutical sciences 2003;92(9):1805-20.
2003: Kueltzo Lisa A; Middaugh C Russell
Structural characterization of bovine granulocyte colony stimulating factor: effect of temperature and pH.
Journal of pharmaceutical sciences 2003;92(9):1793-804.
2003: Kueltzo Lisa A; Middaugh C Russell
Nonclassical transport proteins and peptides: an alternative to classical macromolecule delivery systems.
Journal of pharmaceutical sciences 2003;92(9):1754-72.
2003: Choosakoonkriang Sirirat; Lobo Brian A; Koe Gary S; Koe Janet G; Middaugh C Russell
Biophysical characterization of PEI/DNA complexes.
Journal of pharmaceutical sciences 2003;92(8):1710-22.
2003: Tiyaboonchai Waree; Woiszwillo James; Middaugh C Russell
Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(4):191-202.
2003: Wiethoff Christopher M; Gill Michelle L; Koe Gary S; Koe Janet G; Middaugh C Russell
A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles.
Journal of pharmaceutical sciences 2003;92(6):1272-85.
2003: Lobo Brian A; Koe Gary S; Koe Janet G; Middaugh C Russell
Thermodynamic analysis of binding and protonation in DOTAP/DOPE (1:1): DNA complexes using isothermal titration calorimetry.
Biophysical chemistry 2003;104(1):67-78.
2003: Tiyaboonchai Waree; Woiszwillo James; Sims Robert C; Middaugh C Russell
Insulin containing polyethylenimine-dextran sulfate nanoparticles.
International journal of pharmaceutics 2003;255(1-2):139-51.
2003: Rexroad Jason; Wiethoff Christopher M; Green Anthony P; Kierstead Timothy D; Scott Miller O; Middaugh C Russell
Structural stability of adenovirus type 5.
Journal of pharmaceutical sciences 2003;92(3):665-78.
2003: Braun Chad S; Jas Gouri S; Choosakoonkriang Sirirat; Koe Gary S; Smith Janet G; Middaugh C Russell
The structure of DNA within cationic lipid/DNA complexes.
Biophysical journal 2003;84(2 Pt 1):1114-23.
2003: Brandau Duane T; Jones Latoya S; Wiethoff Christopher M; Rexroad Jason; Middaugh C Russell
Thermal stability of vaccines.
Journal of pharmaceutical sciences 2003;92(2):218-31.
2003: Wiethoff Christopher M; Middaugh C Russell
Barriers to nonviral gene delivery.
Journal of pharmaceutical sciences 2003;92(2):203-17.
2003: Choosakoonkriang Sirirat; Wiethoff Christopher M; Koe Gary S; Koe Janet G; Anchordoquy Thomas J; Middaugh C Russell
An infrared spectroscopic study of the effect of hydration on cationic lipid/DNA complexes.
Journal of pharmaceutical sciences 2003;92(1):115-30.
2003: Kueltzo Lisa A; Osiecki John; Barker Jeff; Picking Wendy L; Ersoy Baran; Picking William D; Middaugh C Russell
Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri.
The Journal of biological chemistry 2003;278(5):2792-8.
2002: Wiethoff Christopher M; Gill Michelle L; Koe Gary S; Koe Janet G; Middaugh C Russell
The structural organization of cationic lipid-DNA complexes.
The Journal of biological chemistry 2002;277(47):44980-7.
2002: Maclean Donald S; Qian Quansheng; Middaugh C Russell
Stabilization of proteins by low molecular weight multi-ions.
Journal of pharmaceutical sciences 2002;91(10):2220-9.
2002: Huang Chin-Yi; Ma San San; Lee Sandra; Radhakrishnan Ramachandran; Braun Chad S; Choosakoonkriang Sirirat; Wiethoff Chris M; Lobo Brian A; Middaugh C Russell
Enhancements in gene expression by the choice of plasmid DNA formulations containing neutral polymeric excipients.
Journal of pharmaceutical sciences 2002;91(5):1371-81.
2002: Souillac Pierre O; Middaugh C Russell; Rytting J Howard
Investigation of protein/carbohydrate interactions in the dried state. 2. Diffuse reflectance FTIR studies.
International journal of pharmaceutics 2002;235(1-2):207-18.
2002: Lobo Brian A; Rogers Sheila A; Choosakoonkriang Sirirat; Smith Janet G; Koe Gary; Middaugh C Russell
Differential scanning calorimetric studies of the thermal stability of plasmid DNA complexed with cationic lipids and polymers.
Journal of pharmaceutical sciences 2002;91(2):454-66.
2002: Tatulian Suren A; Chen Baowei; Li Jinhui; Negash Sewite; Middaugh C Russell; Bigelow Diana J; Squier Thomas C
The inhibitory action of phospholamban involves stabilization of alpha-helices within the Ca-ATPase.
Biochemistry 2002;41(3):741-51.
2002: Souillac Pierre O; Costantino Henry R; Middaugh C Russell; Rytting J Howard
Investigation of protein/carbohydrate interactions in the dried state. 1. Calorimetric studies.
Journal of pharmaceutical sciences 2002;91(1):206-16.
2002: Volkin David B; Sanyal Gautam; Burke Carl J; Middaugh C Russell
Preformulation studies as an essential guide to formulation development and manufacture of protein pharmaceuticals.
Pharmaceutical biotechnology 2002;14():1-46.
2001: Edwards K L; Kueltzo L A; Fisher M T; Middaugh C R
Complex effects of molecular chaperones on the aggregation and refolding of fibroblast growth factor-1.
Archives of biochemistry and biophysics 2001;393(1):14-21.
2001: Wiethoff C M; Smith J G; Koe G S; Middaugh C R
The potential role of proteoglycans in cationic lipid-mediated gene delivery. Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans.
The Journal of biological chemistry 2001;276(35):32806-13.
2001: Tiyaboonchai W; Woiszwillo J; Middaugh C R
Formulation and characterization of amphotericin B-polyethylenimine-dextran sulfate nanoparticles.
Journal of pharmaceutical sciences 2001;90(7):902-14.
2001: Mach H; Middaugh C R; Denslow N
Determining the identity and purity of recombinant proteins by UV absorption spectroscopy.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 7():Unit 7.2.
2001: Chastain M; Simon A J; Soper K A; Holder D J; Montgomery D L; Sagar S L; Casimiro D R; Middaugh C R
Antigen levels and antibody titers after DNA vaccination.
Journal of pharmaceutical sciences 2001;90(4):474-84.
2001: Choosakoonkriang S; Wiethoff C M; Anchordoquy T J; Koe G S; Smith J G; Middaugh C R
Infrared spectroscopic characterization of the interaction of cationic lipids with plasmid DNA.
The Journal of biological chemistry 2001;276(11):8037-43.
2001: Lobo B A; Davis A; Koe G; Smith J G; Middaugh C R
Isothermal titration calorimetric analysis of the interaction between cationic lipids and plasmid DNA.
Archives of biochemistry and biophysics 2001;386(1):95-105.
2001: Grillo A O; Edwards K L; Kashi R S; Shipley K M; Hu L; Besman M J; Middaugh C R
Conformational origin of the aggregation of recombinant human factor VIII.
Biochemistry 2001;40(2):586-95.
2000: Kueltzo L A; Normand N; O'Hare P; Middaugh C R
Conformational lability of herpesvirus protein VP22.
The Journal of biological chemistry 2000;275(43):33213-21.
2000: Kueltzo L A; Middaugh C R
Potential use of non-classical pathways for the transport of macromolecular drugs.
Expert opinion on investigational drugs 2000;9(9):2039-50.
1999: Larive C K; Lunte S M; Zhong M; Perkins M D; Wilson G S; Gokulrangan G; Williams T; Afroz F; Schöneich C; Derrick T S; Middaugh C R; Bogdanowich-Knipp S
Separation and analysis of peptides and proteins.
Analytical chemistry 1999;71(12):389R-423R.
1998: Lobo B; Ropp J D; Middaugh C R
The 1st annual meeting of the American Society of Gene Therapy.
Expert opinion on investigational drugs 1998;7(10):1719-26.
1998: Middaugh C R; Edwards K L
Recent advances in our understanding of protein conformational stability from a pharmaceutical perspective.
Expert opinion on investigational drugs 1998;7(9):1493-500.
1998: Middaugh C R; Evans R K; Montgomery D L; Casimiro D R
Analysis of plasmid DNA from a pharmaceutical perspective.
Journal of pharmaceutical sciences 1998;87(2):130-46.
1997: Volkin D B; Mach H; Middaugh C R
Degradative covalent reactions important to protein stability.
Molecular biotechnology 1997;8(2):105-22.
1997: Bruner M W; Goldstein J; Middaugh C R; Brooks M A; Volkin D B
Size exclusion HPLC method for the determination of acidic fibroblast growth factor in viscous formulations.
Journal of pharmaceutical and biomedical analysis 1997;15(12):1929-35.
1997: Volkin D B; Burke C J; Marfia K E; Oswald C B; Wolanski B; Middaugh C R
Size and conformational stability of the hepatitis A virus used to prepare VAQTA, a highly purified inactivated vaccine.
Journal of pharmaceutical sciences 1997;86(6):666-73.
1996: Mayer E J; McKenna E; Garsky V M; Burke C J; Mach H; Middaugh C R; Sardana M; Smith J S; Johnson R G
Biochemical and biophysical comparison of native and chemically synthesized phospholamban and a monomeric phospholamban analog.
The Journal of biological chemistry 1996;271(3):1669-77.
1996: Sanyal G; Marquis-Omer D; Middaugh C R
Biophysical characterization and formulation of TP40: A chimeric protein that requires a pH-dependent conformational change for its biological activity.
Pharmaceutical biotechnology 1996;9():365-92.
1996: Volkin D B; Middaugh C R
The characterization, stabilization, and formulation of acidic fibroblast growth factor.
Pharmaceutical biotechnology 1996;9():181-217.
1996: Volkin D B; Burke C J; Sanyal G; Middaugh C R
Analysis of vaccine stability.
Developments in biological standardization 1996;87():135-42.
1995: Brown P M; Tagari P; Rowan K R; Yu V L; O'Neill G P; Middaugh C R; Sanyal G; Ford-Hutchinson A W; Nicholson D W
Epitope-labeled soluble human interleukin-5 (IL-5) receptors. Affinity cross-link labeling, IL-5 binding, and biological activity.
The Journal of biological chemistry 1995;270(49):29236-43.
1995: Mach H; Middaugh C R
Interaction of partially structured states of acidic fibroblast growth factor with phospholipid membranes.
Biochemistry 1995;34(31):9913-20.
1995: Mortishire-Smith R J; Pitzenberger S M; Burke C J; Middaugh C R; Garsky V M; Johnson R G
Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure.
Biochemistry 1995;34(23):7603-13.
1995: Sanyal G; Marquis-Omer D; Waxman L; Mach H; Ryan J A; O'Brien Gress J; Middaugh C R
Spectroscopic characterization of tick anticoagulant peptide.
Biochimica et biophysica acta 1995;1249(1):100-8.
1995: Volkin D B; Verticelli A M; Bruner M W; Marfia K E; Tsai P K; Sardana M K; Middaugh C R
Deamidation of polyanion-stabilized acidic fibroblast growth factor.
Journal of pharmaceutical sciences 1995;84(1):7-11.
1995: Mach H; Volkin D B; Burke C J; Middaugh C R
Ultraviolet absorption spectroscopy.
Methods in molecular biology (Clifton, N.J.) 1995;40():91-114.
1995: Volkin D B; Mach H; Middaugh C R
Degradative covalent reactions important to protein stability.
Methods in molecular biology (Clifton, N.J.) 1995;40():35-63.
1995: Middaugh C R; Mach H; Ryan J A; Sanyal G; Volkin D B
Infrared spectroscopy.
Methods in molecular biology (Clifton, N.J.) 1995;40():137-56.
1994: Mach H; Middaugh C R
Simultaneous monitoring of the environment of tryptophan, tyrosine, and phenylalanine residues in proteins by near-ultraviolet second-derivative spectroscopy.
Analytical biochemistry 1994;222(2):323-31.
1994: Chavan A J; Haley B E; Volkin D B; Marfia K E; Verticelli A M; Bruner M W; Draper J P; Burke C J; Middaugh C R
Interaction of nucleotides with acidic fibroblast growth factor (FGF-1).
Biochemistry 1994;33(23):7193-202.
1994: Gress J O; Marquis-Omer D; Middaugh C R; Sanyal G
Evidence for an equilibrium intermediate in the folding-unfolding pathway of a transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein.
Biochemistry 1994;33(9):2620-7.
1994: Mach H; Middaugh C R
Probing the affinity of polyanions for acidic fibroblast growth factor by unfolding kinetics.
Archives of biochemistry and biophysics 1994;309(1):36-42.
1993: Tsai P K; Bruner M W; Irwin J I; Ip C C; Oliver C N; Nelson R W; Volkin D B; Middaugh C R
Origin of the isoelectric heterogeneity of monoclonal immunoglobulin h1B4.
Pharmaceutical research 1993;10(11):1580-6.
1993: Volkin D B; Verticelli A M; Marfia K E; Burke C J; Mach H; Middaugh C R
Sucralfate and soluble sucrose octasulfate bind and stabilize acidic fibroblast growth factor.
Biochimica et biophysica acta 1993;1203(1):18-26.
1993: Mach H; Middaugh C R
Measuring protein spectra in the presence of light scattering.
BioTechniques 1993;15(2):240-2.
1993: Mach H; Ryan J A; Burke C J; Volkin D B; Middaugh C R
Partially structured self-associating states of acidic fibroblast growth factor.
Biochemistry 1993;32(30):7703-11.
1993: Middaugh C R; Thomson J A; Burke C J; Mach H; Naylor A M; Bogusky M J; Ryan J A; Pitzenberger S M; Ji H; Cordingley J S
Structure of synthetic peptide analogues of an eggshell protein of Schistosoma mansoni.
Protein science : a publication of the Protein Society 1993;2(6):900-14.
1993: Burke C J; Volkin D B; Mach H; Middaugh C R
Effect of polyanions on the unfolding of acidic fibroblast growth factor.
Biochemistry 1993;32(25):6419-26.
1993: Tsai P K; Volkin D B; Dabora J M; Thompson K C; Bruner M W; Gress J O; Matuszewska B; Keogan M; Bondi J V; Middaugh C R
Formulation design of acidic fibroblast growth factor.
Pharmaceutical research 1993;10(5):649-59.
1993: Mach H; Volkin D B; Burke C J; Middaugh C R; Linhardt R J; Fromm J R; Loganathan D; Mattsson L
Nature of the interaction of heparin with acidic fibroblast growth factor.
Biochemistry 1993;32(20):5480-9.
1993: Sanyal G; Marquis-Omer D; Gress J O; Middaugh C R
A transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein undergoes pH-dependent conformational changes conducive to membrane interaction.
Biochemistry 1993;32(13):3488-97.
1993: Middaugh C R; Steadman B L; Schurtenberger P; Lee D C; Chlebowski J F
Changes in structure of alpha 2-macroglobulin upon reaction with trypsin as assessed by light scattering and differential scanning calorimetry.
Biochimica et biophysica acta 1993;1161(2-3):328-32.
1993: Volkin D B; Tsai P K; Dabora J M; Gress J O; Burke C J; Linhardt R J; Middaugh C R
Physical stabilization of acidic fibroblast growth factor by polyanions.
Archives of biochemistry and biophysics 1993;300(1):30-41.
1992: Wiedlocha A; Madshus I H; Mach H; Middaugh C R; Olsnes S
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector.
The EMBO journal 1992;11(13):4835-42.
1992: Middaugh C R; Mach H; Burke C J; Volkin D B; Dabora J M; Tsai P K; Bruner M W; Ryan J A; Marfia K E
Nature of the interaction of growth factors with suramin.
Biochemistry 1992;31(37):9016-24.
1992: Burke C J; Sanyal G; Bruner M W; Ryan J A; LaFemina R L; Robbins H L; Zeft A S; Middaugh C R; Cordingley M G
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.
The Journal of biological chemistry 1992;267(14):9639-44.
1992: Mach H; Middaugh C R; Lewis R V
Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins.
Analytical biochemistry 1992;200(1):74-80.
1992: Mach H; Middaugh C R; Lewis R V
Detection of proteins and phenol in DNA samples with second-derivative absorption spectroscopy.
Analytical biochemistry 1992;200(1):20-6.
1991: Dabora J M; Sanyal G; Middaugh C R
Effect of polyanions on the refolding of human acidic fibroblast growth factor.
The Journal of biological chemistry 1991;266(35):23637-40.
1991: Matsuno K; Lewis R V; Middaugh C R
The interaction of gamma-crystallins with model surfaces.
Archives of biochemistry and biophysics 1991;291(2):349-55.
1991: Marquis-Omer D; Sanyal G; Volkin D B; Marcy A I; Chan H K; Ryan J A; Middaugh C R
Stabilization of the FK506 binding protein by ligand binding.
Biochemical and biophysical research communications 1991;179(2):741-8.
1991: Brandau D T; Lawson E Q; Schubert C F; Day N K; Matsuno K; Middaugh C R
The interaction of cryoimmunoglobulins with a model surface.
Molecular immunology 1991;28(9):1019-26.
1991: Mach H; Dong Z; Middaugh C R; Lewis R V
Conformational stability of Cu,Zn-superoxide dismutase, the apoprotein, and its zinc-substituted derivatives: second-derivative spectroscopy of phenylalanine and tyrosine residues.
Archives of biochemistry and biophysics 1991;287(1):41-7.
1991: Mach H; Thomson J A; Middaugh C R; Lewis R V
Examination of phenylalanine microenvironments in proteins by second-derivative absorption spectroscopy.
Archives of biochemistry and biophysics 1991;287(1):33-40.
1991: Dong Z; Lewis R V; Middaugh C R
Molecular mechanism of spider silk elasticity.
Archives of biochemistry and biophysics 1991;284(1):53-7.
1990: Mach H; Trautman P A; Thomson J A; Lewis R V; Middaugh C R
Inhibition of alpha-crystallin aggregation by gamma-crystallin.
The Journal of biological chemistry 1990;265(9):4844-8.
1989: Steadman B L; Trautman P A; Lawson E Q; Raymond M J; Mood D A; Thomson J A; Middaugh C R
A differential scanning calorimetric study of the bovine lens crystallins.
Biochemistry 1989;28(25):9653-8.
1989: Mach H; Thomson J A; Middaugh C R
Quantitative analysis of protein mixtures by second derivative absorption spectroscopy.
Analytical biochemistry 1989;181(1):79-85.
1989: Aird S D; Middaugh C R; Kaiser I I
Spectroscopic characterization of textilotoxin, a presynaptic neurotoxin from the venom of the Australian eastern brown snake (Pseudonaja t. textilis).
Biochimica et biophysica acta 1989;997(3):219-23.
1989: Aird S D; Steadman B L; Middaugh C R; Kaiser I I
Comparative spectroscopic studies of four crotoxin homologs and their subunits.
Biochimica et biophysica acta 1989;997(3):211-8.
1988: Lawson E Q; Brandau D T; Trautman P A; Middaugh C R
Electrostatic properties of cryoimmunoglobulins.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1218-22.
1987: Lawson E Q; Brandau D T; Trautman P A; Aziz S E; Middaugh C R
Kinetics of the precipitation of cryoimmunoglobulins.
Molecular immunology 1987;24(9):897-905.
1987: Brandau D T; Lawson E Q; Trautman P A; Middaugh C R
Thermodynamics of monoclonal and mixed cryoimmunoglobin solubilization.
Immunological investigations 1987;16(1):21-32.
1986: Brandau D T; Trautman P A; Steadman B L; Lawson E Q; Middaugh C R
The temperature-dependent stoichiometry of mixed cryoimmunoglobulins.
The Journal of biological chemistry 1986;261(35):16385-91.
1986: Brandau D T; Lawson E Q; Middaugh C R; Litman G W
The effect of interchain disulfide bond cleavage on the cold induced precipitation of cryoimmunoglobulins.
Immunological investigations 1986;15(5):447-62.
1985: Harmatz D; Ji T H; Middaugh C R
Aggregation state of the gonadotropin receptor.
Biochemical and biophysical research communications 1985;127(2):687-92.
1984: Sadler A J; Horsch J G; Lawson E Q; Harmatz D; Brandau D T; Middaugh C R
Near-infrared photoacoustic spectroscopy of proteins.
Analytical biochemistry 1984;138(1):44-51.
1984: Lawson E Q; Sadler A J; Harmatz D; Brandau D T; Micanovic R; MacElroy R D; Middaugh C R
A simple experimental model for hydrophobic interactions in proteins.
The Journal of biological chemistry 1984;259(5):2910-2.
1981: Lawson E Q; Schubert C F; Lewis R V; Middaugh C R
The solubility of bovine lens crystallins.
The Journal of biological chemistry 1981;256(13):6523-5.
1980: Tisel W A; Haire R N; White J G; Rosenberg A; Middaugh C R
Polyphasic linkage between protein solubility and ligand binding in the hemoglobin-polyethylene glycol system.
The Journal of biological chemistry 1980;255(19):8975-8.
1980: Middaugh C R; Lawson E Q; Litman G W; Tisel W A; Mood D A; Rosenberg A
Thermodynamic basis for the abnormal solubility of monoclonal cryoimmunoglobulins.
The Journal of biological chemistry 1980;255(14):6532-4.
1980: Middaugh C R; Lawson E Q
Analysis of protein association by partitioning in aqueous two-phase polymer systems: applications to the tetramer-dimer dissociation of hemoglobin.
Analytical biochemistry 1980;105(2):364-8.

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