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Frank Miedema

Research Profile

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HIV-1

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TOP 3
Ineke den Braber; Koos Gaiser; Frank Miedema; Ramona Mögling; Tendai Mugwagwa; Erik Mul; Sigrid A Otto; An F C Ruiter; Elise H R Schrijver; Gerrit Spierenburg; Nienke Vrisekoop; Liset Westera; Neeltje Willems; Anne Bregje de Boer; Mariëtte T Ackermans; José A M Borghans; Rob J De Boer; kiki tesselaar
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
Ingrid M M Schellens; Hanneke Schuitemaker; Debbie Van Baarle; Hanneke W M van Deutekom; Can Keşmir; Neeltje Kootstra; Frank Miedema; Marjon Navis; Ben Berkhout; Brigitte Boeser-Nunnink; José A M Borghans
Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic.
Frank Miedema
Grand Challenges in the Immunology of HIV and AIDS.

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All Publications

2012: Ineke den Braber; Koos Gaiser; Frank Miedema; Ramona Mögling; Tendai Mugwagwa; Erik Mul; Sigrid A Otto; An F C Ruiter; Elise H R Schrijver; Gerrit Spierenburg; Nienke Vrisekoop; Liset Westera; Neeltje Willems; Anne Bregje de Boer; Mariëtte T Ackermans; José A M Borghans; Rob J De Boer; kiki tesselaar
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
Immunity 2012;36(2):288-97.
2011: Ingrid M M Schellens; Hanneke Schuitemaker; Debbie Van Baarle; Hanneke W M van Deutekom; Can Keşmir; Neeltje Kootstra; Frank Miedema; Marjon Navis; Ben Berkhout; Brigitte Boeser-Nunnink; José A M Borghans
Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic.
AIDS (London, England) 2011;25(14):1691-700.
2011: Frank Miedema
Grand Challenges in the Immunology of HIV and AIDS.
Frontiers in immunology 2011;2():20.
2010: Ingrid M M Schellens; Katalin Pogany; Geertje H A Westerlaken; José A M Borghans; Frank Miedema; Irene G M van Valkengoed; Frank P Kroon; Joep M A Lange; Kees Brinkman; Jan M Prins; Debbie Van Baarle
Immunological analysis of treatment interruption after early highly active antiretroviral therapy.
Viral immunology 2010;23(6):609-18.
2008: Frank Miedema
A brief history of HIV vaccine research: stepping back to the drawing board?
AIDS (London, England) 2008;22(14):1699-703.
2008: Radjin Steingrover; Katalyn Pogány; Evian Fernandez Garcia; Suzanne Jurriaans; Kees Brinkman; Hanneke Schuitemaker; Frank Miedema; Joep M A Lange; Jan M Prins
HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy.
AIDS (London, England) 2008;22(13):1583-8.
2008: Nienke Vrisekoop; Rogier van Gent; Anne Bregje de Boer; Sigrid A Otto; Jan C C Borleffs; Radjin Steingrover; Jan M Prins; Taco W Kuijpers; Tom F W Wolfs; Sibyl P M Geelen; Irma Vulto; Peter Lansdorp; kiki tesselaar; José A M Borghans; Frank Miedema
Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1573-81.
2008: Nienke Vrisekoop; Ineke den Braber; Anne Bregje de Boer; An F C Ruiter; Mariëtte T Ackermans; Saskia N van der Crabben; Elise H R Schrijver; Gerrit Spierenburg; Hans P Sauerwein; Mette D Hazenberg; Rob J De Boer; Frank Miedema; José A M Borghans; kiki tesselaar
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6115-20.
2008: Marjon Navis; Ingrid M M Schellens; Peter van Swieten; José A M Borghans; Frank Miedema; Neeltje Kootstra; Debbie Van Baarle; Hanneke Schuitemaker
A nonprogressive clinical course in HIV-infected individuals expressing human leukocyte antigen B57/5801 is associated with preserved CD8+ T lymphocyte responsiveness to the HW9 epitope in Nef.
The Journal of infectious diseases 2008;197(6):871-9.
2008: kiki tesselaar; Frank Miedema
Growth hormone resurrects adult human thymus during HIV-1 infection.
The Journal of clinical investigation 2008;118(3):844-7.
2008: Ingrid M M Schellens; Can Keşmir; Frank Miedema; Debbie Van Baarle; José A M Borghans
An unanticipated lack of consensus cytotoxic T lymphocyte epitopes in HIV-1 databases: the contribution of prediction programs.
AIDS (London, England) 2008;22(1):33-7.
2008: Ingrid M M Schellens; José A M Borghans; Christine A Jansen; Iris M De Cuyper; Ronald B Geskus; Debbie Van Baarle; Frank Miedema
Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.
PloS one 2008;3(7):e2745.
2007: Joost N Vermeulen; Jan M Prins; Evelien Bunnik; C Erik Hack; Suzanne Jurriaans; Frank Miedema; Joep M A Lange; Hanneke Schuitemaker
Intravenous immunoglobulin (IVIG) treatment for modulation of immune activation in human immunodeficiency virus type 1 infected therapy-naive individuals.
AIDS research and human retroviruses 2007;23(11):1348-53.
2007: Marjon Navis; Ingrid M M Schellens; Debbie Van Baarle; José A M Borghans; Peter van Swieten; Frank Miedema; Neeltje Kootstra; Hanneke Schuitemaker
Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3133-43.
2007: Miriam Casula; Nienke Vrisekoop; Ferdinand W N M Wit; Michel P De Baar; Anthony de Ronde; Frank Miedema; Peter Reiss
Mitochondrial DNA decline in T cells of HIV-1 seroconverters may be dependent on immune activation.
The Journal of infectious diseases 2007;196(3):371-6.
2007: Corine Bronke; Christine A Jansen; Geertje H A Westerlaken; Iris M De Cuyper; Frank Miedema; kiki tesselaar; Debbie Van Baarle
Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease.
Clinical immunology (Orlando, Fla.) 2007;124(2):190-9.
2007: shivani choudhary; Nienke Vrisekoop; Christine A Jansen; Sigrid A Otto; Hanneke Schuitemaker; Frank Miedema; David Camerini
Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease.
Journal of virology 2007;81(16):8838-42.
2007: Aster Tsegaye; Leonie Ran; Dawit Wolday; Beyene Petros; Wendelien Dorigo; Erwan Piriou; Tsehaynesh Messele; Eduard Sanders; Tesfaye Tilahun; Deresse Eshetu; Hanneke Schuitemaker; Roel A Coutinho; Frank Miedema; José A M Borghans; Debbie Van Baarle
HIV-1 Subtype C gag-specific T-cell responses in relation to human leukocyte antigens in a diverse population of HIV-infected Ethiopians.
Journal of acquired immune deficiency syndromes (1999) 2007;45(4):389-400.
2007: Aster Tsegaye; Leonie Ran; Dawit Wolday; Beyene Petros; Nening M Nanlohy; Hailu Meles; Mulu Girma; Ermias Hailu; José A M Borghans; Frank Miedema; Debbie Van Baarle
Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians.
AIDS (London, England) 2007;21(3):369-72.
2006: José A M Borghans; R G M Bredius; Mette D Hazenberg; Helene Roelofs; Els C Jol-van der Zijde; Jeroen Heidt; Sigrid A Otto; Taco W Kuijpers; Willem E Fibbe; Jaak M Vossen; Frank Miedema; Maarten J D van Tol
Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency.
Blood 2006;108(2):763-9.
2006: Belete Tegbaru; Dawit Wolday; Tsehaynesh Messele; Mengistu Legesse; Yared Mekonnen; Frank Miedema; Debbie Van Baarle
Tuberculin skin test conversion and reactivity rates among adults with and without human immunodeficiency virus in urban settings in Ethiopia.
Clinical and vaccine immunology : CVI 2006;13(7):784-9.
2006: Christine A Jansen; Debbie Van Baarle; Frank Miedema
HIV-specific CD4+ T cells and viremia: who's in control?
Trends in immunology 2006;27(3):119-24.
2006: Christine A Jansen; Iris M De Cuyper; Berend Hooibrink; Akke K van der Bij; Debbie Van Baarle; Frank Miedema
Prognostic value of HIV-1 Gag-specific CD4+ T-cell responses for progression to AIDS analyzed in a prospective cohort study.
Blood 2006;107(4):1427-33.
2006: Mark J Geels; Christine A Jansen; Elly Baan; Iris M De Cuyper; Gijs J M van Schijndel; Hanneke Schuitemaker; Jaap Goudsmit; Georgios Pollakis; Frank Miedema; William A Paxton; Debbie Van Baarle
CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individuals.
Virology 2006;345(1):209-19.
2006: Frank Miedema
T cell dynamics and protective immunity in HIV infection: a brief history of ideas.
Current opinion in HIV and AIDS 2006;1(1):1-2.
2006: Christine A Jansen; Erwan Piriou; Iris M De Cuyper; Karel van Dort; Joep M A Lange; Frank Miedema; Debbie Van Baarle
Long-term highly active antiretroviral therapy in chronic HIV-1 infection: evidence for reconstitution of antiviral immunity.
Antiviral therapy 2006;11(1):105-16.
2005: Nienke Vrisekoop; Sanjay U C Sankatsing; Christine A Jansen; Marijke Th L Roos; Sigrid A Otto; Hanneke Schuitemaker; Joep M A Lange; Jan M Prins; Frank Miedema
Short communication: No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naive acute and chronic HIV-1-infected patients.
AIDS research and human retroviruses 2005;21(12):991-6.
2005: Fransje Koning; Sigrid A Otto; Mette D Hazenberg; Linda Dekker; Maria Prins; Frank Miedema; Hanneke Schuitemaker
Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6117-22.
2005: Asrat Hailu; Debbie Van Baarle; Gerlinde J Knol; Nega Berhe; Frank Miedema; Piet A Kager
T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani.
Clinical immunology (Orlando, Fla.) 2005;117(2):182-91.
2005: Erwan Piriou; Karel van Dort; Nening M Nanlohy; Marinus H J van Oers; Frank Miedema; Debbie Van Baarle
Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma.
Blood 2005;106(9):3166-74.
2005: Yared Mekonnen; Ronald B Geskus; Jan C M Hendriks; Tsehaynesh Messele; José A M Borghans; Frank Miedema; Dawit Wolday; Roel A Coutinho; Nicole Dukers
Low CD4 T cell counts before HIV-1 seroconversion do not affect disease progression in Ethiopian factory workers.
The Journal of infectious diseases 2005;192(5):739-48.
2005: Nico Kloosterboer; Paul H P Groeneveld; Christine A Jansen; Teun J K van der Vorst; Fransje Koning; Carel N Winkel; Ashley J Duits; Frank Miedema; Debbie Van Baarle; Ronald P van Rij; Kees Brinkman; Hanneke Schuitemaker
Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virus.
Virology 2005;339(1):70-80.
2005: Erwan Piriou; Christine A Jansen; Karel van Dort; Iris M De Cuyper; Nening M Nanlohy; Joep M A Lange; Marinus H J van Oers; Frank Miedema; Debbie Van Baarle
Reconstitution of EBV latent but not lytic antigen-specific CD4+ and CD8+ T cells after HIV treatment with highly active antiretroviral therapy.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):2010-7.
2005: Christine A Jansen; Iris M De Cuyper; Radjin Steingrover; Suzanne Jurriaans; Sanjay U C Sankatsing; Jan M Prins; Joep M A Lange; Debbie Van Baarle; Frank Miedema
Analysis of the effect of highly active antiretroviral therapy during acute HIV-1 infection on HIV-specific CD4 T cell functions.
AIDS (London, England) 2005;19(11):1145-54.
2005: Dawit Wolday; Belete Tegbaru; Afework Kassu; Tsehaynesh Messele; Roel A Coutinho; Debbie Van Baarle; Frank Miedema
Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients.
Journal of acquired immune deficiency syndromes (1999) 2005;39(3):265-71.
2005: Corine Bronke; Geertje H A Westerlaken; Frank Miedema; kiki tesselaar; Debbie Van Baarle
Progression to CMV end-organ disease in HIV-1-infected individuals despite abundance of highly differentiated CMV-specific CD8+ T-cells.
Immunology letters 2005;97(2):215-24.
2005: Corine Bronke; Nanette M Palmer; Christine A Jansen; Geertje H A Westerlaken; Abeltje M Polstra; Peter Reiss; Margreet Bakker; Frank Miedema; kiki tesselaar; Debbie Van Baarle
Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease.
The Journal of infectious diseases 2005;191(6):873-80.
2005: Erwan Piriou; Karel van Dort; Nening M Nanlohy; Marinus H J van Oers; Frank Miedema; Debbie Van Baarle
Novel method for detection of virus-specific CD41+ T cells indicates a decreased EBV-specific CD4+ T cell response in untreated HIV-infected subjects.
European journal of immunology 2005;35(3):796-805.
2005: Debbie Van Baarle; Aster Tsegaye; Frank Miedema; Arne Akbar
Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system.
Immunology letters 2005;97(1):19-29.
2005: José A M Borghans; Mette D Hazenberg; Frank Miedema
Limited role for the thymus in SIV pathogenesis.
European journal of immunology 2005;35(1):42-5.
2005: Christine A Jansen; Stefan Kostense; Kristin Vandenberghe; Nening M Nanlohy; Iris M De Cuyper; Erwan Piriou; Erik H Manting; Frank Miedema; Debbie Van Baarle
High responsiveness of HLA-B57-restricted Gag-specific CD8+ T cells in vitro may contribute to the protective effect of HLA-B57 in HIV-infection.
European journal of immunology 2005;35(1):150-8.
2004: Christine A Jansen; Erwan Piriou; Corine Bronke; Jose Vingerhoed; Stefan Kostense; Debbie Van Baarle; Frank Miedema
Characterization of virus-specific CD8(+) effector T cells in the course of HIV-1 infection: longitudinal analyses in slow and rapid progressors.
Clinical immunology (Orlando, Fla.) 2004;113(3):299-309.
2004: Mette D Hazenberg; Sigrid A Otto; Annemarie M C van Rossum; Henriëtte J Scherpbier; Ronald de Groot; Taco W Kuijpers; Joep M A Lange; Dörte Hamann; Rob J De Boer; José A M Borghans; Frank Miedema
Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1.
Blood 2004;104(12):3513-9.
2004: Sanjay U C Sankatsing; Suzanne Jurriaans; Peter van Swieten; Frank van Leth; Marion Cornelissen; Frank Miedema; Joep M A Lange; Hanneke Schuitemaker; Jan M Prins
Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients.
AIDS (London, England) 2004;18(14):1925-31.
2004: Liselotte van Asten; Figen Danisman; Sigrid A Otto; José A M Borghans; Mette D Hazenberg; Roel A Coutinho; Maria Prins; Frank Miedema
Pre-seroconversion immune status predicts the rate of CD4 T cell decline following HIV infection.
AIDS (London, England) 2004;18(14):1885-93.
2004: Erwan Piriou; Karel van Dort; Nening M Nanlohy; Frank Miedema; Marinus H J van Oers; Debbie Van Baarle
Altered EBV viral load setpoint after HIV seroconversion is in accordance with lack of predictive value of EBV load for the occurrence of AIDS-related non-Hodgkin lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6931-7.
2003: Aster Tsegaye; Dawit Wolday; Sigrid Otto; Beyene Petros; Tamrat Assefa; Tsegaye Alebachew; Ermias Hailu; Fekadu Adugna; Worku Measho; Wendelien Dorigo; Arnaud Fontanet; Debbie Van Baarle; Frank Miedema
Immunophenotyping of blood lymphocytes at birth, during childhood, and during adulthood in HIV-1-uninfected Ethiopians.
Clinical immunology (Orlando, Fla.) 2003;109(3):338-46.
2003: Mette D Hazenberg; Sigrid A Otto; Birgit H B van Benthem; Marijke Th L Roos; Roel A Coutinho; Joep M A Lange; Dörte Hamann; Maria Prins; Frank Miedema
Persistent immune activation in HIV-1 infection is associated with progression to AIDS.
AIDS (London, England) 2003;17(13):1881-8.
2003: Mette D Hazenberg; Sigrid A Otto; Dörte Hamann; Marijke Th L Roos; Hanneke Schuitemaker; Rob J De Boer; Frank Miedema
Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation.
AIDS (London, England) 2003;17(10):1419-24.
2003: Pauline Meij; Joost W J van Esser; Hubert G M Niesters; Debbie Van Baarle; Frank Miedema; Neil Blake; Alan B Rickinson; Ingrid Leiner; Eric G Pamer; Bob Lowenberg; Jan J Cornelissen; Jan W Gratama
Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease.
Blood 2003;101(11):4290-7.
2003: Ronald P van Rij; Mette D Hazenberg; Birgit H B van Benthem; Sigrid A Otto; Maria Prins; Frank Miedema; Hanneke Schuitemaker
Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolution.
AIDS research and human retroviruses 2003;19(5):389-98.
2003: Johannes A Bogaards; Gerrit Jan Weverling; Ronald B Geskus; Frank Miedema; Joep M A Lange; Patrick Bossuyt; Jaap Goudsmit
Low versus high CD4 cell count as starting point for introduction of antiretroviral treatment in resource-poor settings: a scenario-based analysis.
Antiviral therapy 2003;8(1):43-50.
2003: Mette D Hazenberg; José A M Borghans; Rob J De Boer; Frank Miedema
Thymic output: a bad TREC record.
Nature immunology 2003;4(2):97-9.
2002: Debbie Van Baarle; Stefan Kostense; Marinus H J van Oers; Dörte Hamann; Frank Miedema
Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue.
Trends in immunology 2002;23(12):586-91.
2002: James W T Cohen Stuart; Dörte Hamann; Jan C C Borleffs; Marijke Roos; Frank Miedema; Charles Boucher; Rob de Boer
Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age.
AIDS (London, England) 2002;16(17):2263-6.
2002: Stephen A Migueles; Alisha C Laborico; W Lesley Shupert; M Shirin Sabbaghian; Ronald L Rabin; Claire W Hallahan; Debbie Van Baarle; Stefan Kostense; Frank Miedema; Mary McLaughlin; Linda Ehler; Julia Metcalf; Shuying Liu; Mark Connors
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.
Nature immunology 2002;3(11):1061-8.
2002: Debbie Van Baarle; Stefan Kostense; Egbert Hovenkamp; Graham S Ogg; Nening M Nanlohy; Margaret F C Callan; Nicole Dukers; Andrew J McMichael; Marinus H J van Oers; Frank Miedema
Lack of Epstein-Barr virus- and HIV-specific CD27- CD8+ T cells is associated with progression to viral disease in HIV-infection.
AIDS (London, England) 2002;16(15):2001-11.
2002: Tobias F Rinke de Wit; Aster Tsegaye; Dawit Wolday; binyam hailu; mathias aklilu; Eduard Sanders; Measho Hagos; Aletta Kliphuis; Georgios Pollakis; Anneke Krol; Ronald B Geskus; Frank Miedema; Jaap Goudsmit; Roel A Coutinho; Arnaud Fontanet
Primary HIV-1 subtype C infection in Ethiopia.
Journal of acquired immune deficiency syndromes (1999) 2002;30(5):463-70.
2002: Debbie Van Baarle; Katja C Wolthers; Egbert Hovenkamp; Hubert G M Niesters; Albert D M E Osterhaus; Frank Miedema; Marinus H J van Oers
Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma.
The Journal of infectious diseases 2002;186(3):405-9.
2002: Jaap Maas; Fabian Termorshuizen; Ronald B Geskus; Wim G Goettsch; Roel A Coutinho; Frank Miedema; Henk Van Loveren
Amsterdam Cohort Study on HIV and AIDS: impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males.
International journal of hygiene and environmental health 2002;205(5):373-7.
2002: Mette D Hazenberg; Sigrid A Otto; Ferdinand W N M Wit; Joep M A Lange; Dörte Hamann; Frank Miedema
Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss.
AIDS (London, England) 2002;16(9):1287-9.
2002: Catharina E A Lindenburg; Ineke Stolte; Miranda W Langendam; Frank Miedema; Ian G Williams; Robert Colebunders; Jonathan N Weber; Martin Fisher; Roel A Coutinho
Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression.
Vaccine 2002;20(17-18):2343-7.
2002: Mette D Hazenberg; Sigrid A Otto; Elmar S D de Pauw; Helene Roelofs; Willem E Fibbe; Dörte Hamann; Frank Miedema
T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events.
Blood 2002;99(9):3449-53.
2002: Stefan Kostense; Sigrid A Otto; Gerlinde J Knol; Erik H Manting; Nening M Nanlohy; Christine Jansen; Joep M A Lange; Marinus H J van Oers; Frank Miedema; Debbie Van Baarle
Functional restoration of human immunodeficiency virus and Epstein-Barr virus-specific CD8(+) T cells during highly active antiretroviral therapy is associated with an increase in CD4(+) T cells.
European journal of immunology 2002;32(4):1080-9.
2002: Stefan Kostense; Kristin Vandenberghe; Jeanine Joling; Debbie Van Baarle; Nening M Nanlohy; Erik H Manting; Frank Miedema
Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS.
Blood 2002;99(7):2505-11.
2002: Elmar S D de Pauw; Sigrid A Otto; Juul Wijnen; Jaak M Vossen; Margreet H van Weel; Hans J Tanke; Frank Miedema; Rein Willemze; Helene Roelofs; Willem E Fibbe
Long-term follow-up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic stem cell exhaustion.
British journal of haematology 2002;116(2):491-6.
2002: Hans J J van der Vliet; B Mary E von Blomberg; Mette D Hazenberg; Nobusuke Nishi; Sigrid A Otto; Birgit H B van Benthem; Maria Prins; Frans A Claessen; Alfons J M van den Eertwegh; Giuseppe Giaccone; Frank Miedema; Rik J Scheper; HERBERT PINEDO
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1490-5.
2001: Jaap Goudsmit; Gerrit Jan Weverling; Lia van der Hoek; Anthony de Ronde; Frank Miedema; Roel A Coutinho; Joep M A Lange; Maarten C Boerlijst
Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains.
AIDS (London, England) 2001;15(17):2293-301.
2001: Annemarie M C van Rossum; Henriëtte J Scherpbier; Ellen G van Lochem; Nadine Pakker; WA Slieker; Katja C Wolthers; Marijke Th L Roos; J H Kuijpers; Herbert Hooijkaas; Nico G Hartwig; S P M Geelen; Tom F W Wolfs; Joep M A Lange; Frank Miedema; Ronald de Groot
Therapeutic immune reconstitution in HIV-1-infected children is independent of their age and pretreatment immune status.
AIDS (London, England) 2001;15(17):2267-75.
2001: Mette D Hazenberg; M C Verschuren; Dörte Hamann; Frank Miedema; Jacques J M van Dongen
T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation.
Journal of molecular medicine (Berlin, Germany) 2001;79(11):631-40.
2001: Catharina E A Lindenburg; Miranda W Langendam; B H Benthem; Frank Miedema; Roel A Coutinho
No evidence that vaccination with a polysaccharide pneumococcal vaccine protects drug users against all-cause pneumonia.
AIDS (London, England) 2001;15(10):1315-7.
2001: Debbie Van Baarle; Egbert Hovenkamp; Margaret F C Callan; Katja C Wolthers; Stefan Kostense; LC Tan; Hubert G M Niesters; Albert D M E Osterhaus; Andrew J McMichael; Marinus H J van Oers; Frank Miedema
Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma.
Blood 2001;98(1):146-55.
2001: Stefan Kostense; Frank M Raaphorst; Jeanine Joling; Daan W Notermans; Jan M Prins; Sven A Danner; Peter Reiss; Joep M A Lange; Judy M Teale; Frank Miedema
T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: effect of antiretroviral therapy.
AIDS (London, England) 2001;15(9):1097-107.
2001: NA Foudraine; Suzanne Jurriaans; Gerrit Jan Weverling; David Burger; Richard Hoetelmans; Marijke Th L Roos; JJ Maas; Frank Miedema; Peter Reiss; Peter Portegies; Frank de Wolf; Joep M A Lange
Durable HIV-1 suppression with indinavir after failing lamivudine-containing double nucleoside therapy: a randomized controlled trial.
Antiviral therapy 2001;6(1):55-62.
2001: Stefan Kostense; Graham S Ogg; Erik H Manting; G Gillespie; Jeanine Joling; Kristin Vandenberghe; E Z Veenhof; Debbie Van Baarle; Suzanne Jurriaans; Michel Klein; Frank Miedema
High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function.
European journal of immunology 2001;31(3):677-86.
2001: Tsehaynesh Messele; Mieke C Brouwer; Mulu Girma; Arnaud Fontanet; Frank Miedema; Dörte Hamann; Tobias F Rinke de Wit
Plasma levels of viro-immunological markers in HIV-infected and non-infected Ethiopians: correlation with cell surface activation markers.
Clinical immunology (Orlando, Fla.) 2001;98(2):212-9.
2000: James W T Cohen Stuart; M D Hazebergh; Dörte Hamann; Sigrid A Otto; Jan C C Borleffs; Frank Miedema; Charles A B Boucher; Rob J De Boer
The dominant source of CD4+ and CD8+ T-cell activation in HIV infection is antigenic stimulation.
Journal of acquired immune deficiency syndromes (1999) 2000;25(3):203-11.
2000: Mette D Hazenberg; Dörte Hamann; Hanneke Schuitemaker; Frank Miedema
T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock.
Nature immunology 2000;1(4):285-9.
2000: Mette D Hazenberg; Sigrid A Otto; James W T Cohen Stuart; M C Verschuren; Jan C C Borleffs; Charles A B Boucher; Roel A Coutinho; Joep M A Lange; Tobias F Rinke de Wit; Aster Tsegaye; Jacques J M van Dongen; Dörte Hamann; Rob J De Boer; Frank Miedema
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection.
Nature medicine 2000;6(9):1036-42.
2000: Marijke Th L Roos; René A W van Lier; Dörte Hamann; Gerlinde J Knol; I Verhoofstad; Debbie Van Baarle; Frank Miedema; P T A Schellekens
Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans.
The Journal of infectious diseases 2000;182(2):451-8.
2000: DR Clark; S Repping; Nadine Pakker; J M Prins; Daan W Notermans; Ferdinand W N M Wit; Peter Reiss; S A Danner; R A Coutinho; Joep M A Lange; Frank Miedema
T-cell progenitor function during progressive human immunodeficiency virus-1 infection and after antiretroviral therapy.
Blood 2000;96(1):242-9.
2000: Tsehaynesh Messele; Marijke Th L Roos; Dörte Hamann; M Koot; Arnaud Fontanet; Frank Miedema; P T A Schellekens; Tobias F Rinke de Wit
Nonradioactive techniques for measurement of in vitro T-cell proliferation: alternatives to the [(3)H]thymidine incorporation assay.
Clinical and diagnostic laboratory immunology 2000;7(4):687-92.
2000: Debbie Van Baarle; Egbert Hovenkamp; Nicole Dukers; Neil Renwick; Marie José Kersten; Jaap Goudsmit; Roel A Coutinho; Frank Miedema; Marinus H J van Oers
High prevalence of Epstein-Barr virus type 2 among homosexual men is caused by sexual transmission.
The Journal of infectious diseases 2000;181(6):2045-9.
2000: Sylvain Fleury; G Paolo Rizzardi; AG Chapuis; Giuseppe Tambussi; C Knabenhans; Eleonora Simeoni; Jean-Yves Meuwly; Jean-Marc Corpataux; Adriano Lazzarin; Frank Miedema; Giuseppe Pantaleo
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5393-8.
2000: K Lindenburg; Miranda W Langendam; J Veenstra; Frank Miedema; R Coutinho
Long-term effects of therapeutic vaccination with rgp 120.
AIDS (London, England) 2000;14(2):203-4.
2000: Mette D Hazenberg; J W Stuart; Sigrid A Otto; Jan C C Borleffs; Charles A B Boucher; Rob J De Boer; Frank Miedema; Dörte Hamann
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).
Blood 2000;95(1):249-55.
1999: Susanne D Nielsen; DR Clark; M Hutchings; S Dam-Larsen; S Repping; Jens Ole Nielsen; Lars Mathiesen; Frank Miedema; John-Erik Stig Hansen
Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons.
The Journal of infectious diseases 1999;180(6):1819-26.
1999: Graham S Ogg; Stefan Kostense; Michel Klein; Suzanne Jurriaans; Dörte Hamann; Andrew J McMichael; Frank Miedema
Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression.
Journal of virology 1999;73(11):9153-60.
1999: Daan W Notermans; Nadine Pakker; Dörte Hamann; NA Foudraine; Robbert H Kauffmann; Pieter L Meenhorst; Jaap Goudsmit; Marijke Th L Roos; P T A Schellekens; Frank Miedema; Sven A Danner
Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults.
The Journal of infectious diseases 1999;180(4):1050-6.
1999: Katja C Wolthers; André J Noest; Sigrid A Otto; Frank Miedema; Rob J De Boer
Normal telomere lengths in naive and memory CD4+ T cells in HIV type 1 infection: a mathematical interpretation.
AIDS research and human retroviruses 1999;15(12):1053-62.
1999: IP Keet; Jianming "James" Tang; Michel Klein; Susan LeBlanc; C Enger; Charles A Rivers; Raymond Apple; Dean L Mann; J J Goedert; Frank Miedema; Richard A Kaslow
Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.
The Journal of infectious diseases 1999;180(2):299-309.
1999: Oscar Pontesilli; Patrizia Carotenuto; SR Kerkhof-Garde; Marijke Th L Roos; IP Keet; Roel A Coutinho; Jaap Goudsmit; Frank Miedema
Lymphoproliferative response to HIV type 1 p24 in long-term survivors of HIV type 1 infection is predictive of persistent AIDS-free infection.
AIDS research and human retroviruses 1999;15(11):973-81.
1999: Dörte Hamann; Stefan Kostense; Katja C Wolthers; Sigrid A Otto; Paul A Baars; Frank Miedema; René A W van Lier
Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division.
International immunology 1999;11(7):1027-33.
1999: Oscar Pontesilli; SR Kerkhof-Garde; Daan W Notermans; NA Foudraine; Marijke Th L Roos; Michel Klein; Sven A Danner; Joep M A Lange; Frank Miedema
Functional T cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy.
The Journal of infectious diseases 1999;180(1):76-86.
1999: Debbie Van Baarle; Egbert Hovenkamp; Marie José Kersten; Michel Klein; Frank Miedema; Marinus H J van Oers
Direct Epstein-Barr virus (EBV) typing on peripheral blood mononuclear cells: no association between EBV type 2 infection or superinfection and the development of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.
Blood 1999;93(11):3949-55.
1999: Oscar Pontesilli; SR Kerkhof-Garde; Nadine Pakker; Daan W Notermans; Marijke Th L Roos; Michel Klein; Sven A Danner; Frank Miedema
Antigen-specific T-lymphocyte proliferative responses during highly active antiretroviral therapy (HAART) of HIV-1 infection.
Immunology letters 1999;66(1-3):213-7.
1999: Tsehaynesh Messele; M Abdulkadir; Arnaud Fontanet; Beyene Petros; Dörte Hamann; M Koot; Marijke Th L Roos; P T A Schellekens; Frank Miedema; Tobias F Rinke de Wit
Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts.
Clinical and experimental immunology 1999;115(3):443-50.
1999: Nadine Pakker; E D Kroon; Marijke Th L Roos; Sigrid A Otto; D Hall; Ferdinand W N M Wit; Dörte Hamann; Marchina E Van Der Ende; Frans A Claessen; Robbert H Kauffmann; Peter P Koopmans; Frank P Kroon; C H ten Napel; Herman Sprenger; Hugo M Weigel; Julio S G Montaner; Joep M A Lange; Peter Reiss; P T A Schellekens; Frank Miedema
Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group.
AIDS (London, England) 1999;13(2):203-12.
1999: NA Foudraine; Egbert Hovenkamp; Daan W Notermans; Pieter L Meenhorst; Michel Klein; Joep M A Lange; Frank Miedema; Peter Reiss
Immunopathology as a result of highly active antiretroviral therapy in HIV-1-infected patients.
AIDS (London, England) 1999;13(2):177-84.
1999: Katja C Wolthers; Sigrid A Otto; G B Wisman; Sylvain Fleury; Peter Reiss; R W ten Kate; A G van der Zee; Frank Miedema
Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection.
Blood 1999;93(3):1011-9.
1999: D R Clark; Rob J De Boer; Katja C Wolthers; Frank Miedema
T cell dynamics in HIV-1 infection.
Advances in immunology 1999;73():301-27.
1998: Stefan Kostense; Frank M Raaphorst; Daan W Notermans; Jeanine Joling; Berend Hooibrink; Nadine Pakker; Sven A Danner; Judy M Teale; Frank Miedema
Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during highly active antiretroviral therapy.
AIDS (London, England) 1998;12(18):F235-40.
1998: Frank P Kroon; G F Rimmelzwaan; Marijke Th L Roos; A D Osterhaus; Dörte Hamann; Frank Miedema; J T van Dissel
Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy.
AIDS (London, England) 1998;12(17):F217-23.
1998: James W T Cohen Stuart; Charles A B Boucher; M Roos; Frank Miedema; Jan C C Borleffs; D Hamman
[Increased serum level of naive CD8+-T-cells during intensive antiretroviral therapy].
Nederlands tijdschrift voor geneeskunde 1998;142(40):2230-1.
1998: JJ Maas; Marijke Th L Roos; IP Keet; E A Mensen; Anneke Krol; J Veenstra; P T A Schellekens; Suzanne Jurriaans; Roel A Coutinho; Frank Miedema
In vivo delayed-type hypersensitivity skin test anergy in human immunodeficiency virus type 1 infection is associated with T cell nonresponsiveness in vitro.
The Journal of infectious diseases 1998;178(4):1024-9.
1998: Oscar Pontesilli; Michel Klein; SR Kerkhof-Garde; Nadine Pakker; Frank de Wolf; Hanneke Schuitemaker; Frank Miedema
Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection.
The Journal of infectious diseases 1998;178(4):1008-18.
1998: Marijke Th L Roos; Maria Prins; M Koot; Frank de Wolf; Margreet Bakker; Roel A Coutinho; Frank Miedema; P T A Schellekens
Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS.
AIDS (London, England) 1998;12(14):1745-51.
1998: Michel Klein; Sjoerd H van der burg; Egbert Hovenkamp; AM Holwerda; Jan Wouter Drijfhout; Cornelis J M Melief; Frank Miedema
Characterization of HLA-B57-restricted human immunodeficiency virus type 1 Gag- and RT-specific cytotoxic T lymphocyte responses.
The Journal of general virology 1998;79 ( Pt 9)():2191-201.
1998: Michel Klein; Sjoerd H van der burg; Oscar Pontesilli; Frank Miedema
Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
Immunology today 1998;19(7):317-24.
1998: Sylvain Fleury; Rob J De Boer; G Paolo Rizzardi; Katja C Wolthers; Sigrid A Otto; C C Welbon; C Graziosi; C Knabenhans; H Soudeyns; Pierre-Alexandre Bart; S Gallant; Jean-Marc Corpataux; M Gillet; Pascal R A Meylan; P Schnyder; Jean-Yves Meuwly; W Spreen; Michel-Pierre Glauser; Frank Miedema; Giuseppe Pantaleo
Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
Nature medicine 1998;4(7):794-801.
1998: Nadine Pakker; Daan W Notermans; Rob J De Boer; Marijke Th L Roos; Frank de Wolf; A Hill; J M Leonard; Sven A Danner; Frank Miedema; P T A Schellekens
Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation.
Nature medicine 1998;4(2):208-14.
1997: Nadine Pakker; Marijke Th L Roos; Remko van Leeuwen; Menno D De Jong; M Koot; Peter Reiss; Joep M A Lange; Frank Miedema; Sven A Danner; P T A Schellekens
Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1997;16(5):318-26.
1997: Frank de Wolf; Ingrid J B Spijkerman; P T A Schellekens; Miranda W Langendam; CL Kuiken; Margreet Bakker; M Roos; Roel A Coutinho; Frank Miedema; Jaap Goudsmit
AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion.
AIDS (London, England) 1997;11(15):1799-806.
1997: Ana Maria de Roda Husman; M Koot; Marion Cornelissen; IP Keet; Mieke C Brouwer; SM Broersen; Margreet Bakker; Marijke Th L Roos; Maria Prins; Frank de Wolf; Roel A Coutinho; Frank Miedema; Jaap Goudsmit; Hanneke Schuitemaker
Association between CCR5 genotype and the clinical course of HIV-1 infection.
Annals of internal medicine 1997;127(10):882-90.
1997: M Koot; Angélique B van 't Wout; Frank Miedema; Hanneke Schuitemaker
Use of Immunological and Viral Parameters to Predict Progression of HIV Infection During Natural Course and Antiretroviral Treatment.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 1997;8(4):243-9.
1997: Sjoerd H van der burg; Michel Klein; Oscar Pontesilli; AM Holwerda; Jan Wouter Drijfhout; W M Kast; Frank Miedema; Cornelis J M Melief
HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3648-54.
1997: Ingrid J B Spijkerman; Maria Prins; Jaap Goudsmit; PJ Veugelers; Roel A Coutinho; Frank Miedema; Frank de Wolf
Early and late HIV-1 RNA level and its association with other markers and disease progression in long-term AIDS-free homosexual men.
AIDS (London, England) 1997;11(11):1383-8.
1997: IP Keet; M Janssen; PJ Veugelers; Frank Miedema; Michel Klein; Jaap Goudsmit; Roel A Coutinho; Frank de Wolf
Longitudinal analysis of CD4 T cell counts, T cell reactivity, and human immunodeficiency virus type 1 RNA levels in persons remaining AIDS-free despite CD4 cell counts <200 for >5 years.
The Journal of infectious diseases 1997;176(3):665-71.
1997: Katja C Wolthers; Sigrid A Otto; SM Lens; René A W van Lier; Frank Miedema; L Meyaard
Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70.
AIDS research and human retroviruses 1997;13(12):1023-9.
1997: Carel A van Baalen; Oscar Pontesilli; RC Huisman; AM Geretti; Michel Klein; Frank de Wolf; Frank Miedema; Rob A Gruters; Albert D M E Osterhaus
Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.
The Journal of general virology 1997;78 ( Pt 8)():1913-8.
1997: Oscar Pontesilli; Michel Klein; SR Kerkhof-Garde; Nadine Pakker; Frank de Wolf; Hanneke Schuitemaker; Frank Miedema
Kinetics of immune functions and virus replication during HIV-1 infection.
Immunology letters 1997;57(1-3):125-30.
1997: Neeltje Kootstra; Frank Miedema; Hanneke Schuitemaker
Analysis of CD8+ T lymphocyte-mediated nonlytic suppression of autologous and heterologous primary human immunodeficiency virus type 1 isolates.
AIDS research and human retroviruses 1997;13(8):685-93.
1997: J Veenstra; PJ Veugelers; IP Keet; A J van der Ven; Frank Miedema; Joep M A Lange; Roel A Coutinho
Rapid disease progression in human immunodeficiency virus type 1-infected individuals with adverse reactions to trimethoprim-sulfamethoxazole prophylaxis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997;24(5):936-41.
1997: Marie José Kersten; Michel Klein; AM Holwerda; Frank Miedema; Marinus H J van Oers
Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma.
The Journal of clinical investigation 1997;99(7):1525-33.
1997: Michel Klein; J Veenstra; AM Holwerda; Marijke Th L Roos; I Gow; G Patou; Roel A Coutinho; Frank de Wolf; Frank Miedema
Gag-specific immune responses after immunization with p17/p24:Ty virus-like particles in HIV type 1-seropositive individuals.
AIDS research and human retroviruses 1997;13(5):393-9.
1997: L Meyaard; Egbert Hovenkamp; Nadine Pakker; T C van der Pouw Kraan; Frank Miedema
Interleukin-12 (IL-12) production in whole blood cultures from human immunodeficiency virus-infected individuals studied in relation to IL-10 and prostaglandin E2 production.
Blood 1997;89(2):570-6.
1997: L Meyaard; Frank Miedema
Immune dysregulation and CD4+ T cell loss in HIV-1 infection.
Springer seminars in immunopathology 1997;18(3):285-303.
1997: BM Brinkman; IP Keet; Frank Miedema; Cornelis L Verweij; Michel Klein
Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1-seropositive persons.
The Journal of infectious diseases 1997;175(1):188-90.
1996: Katja C Wolthers; G Bea; A Wisman; Sigrid A Otto; Ana Maria de Roda Husman; N Schaft; Frank de Wolf; Jaap Goudsmit; Roel A Coutinho; A G van der Zee; L Meyaard; Frank Miedema
T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover.
Science (New York, N.Y.) 1996;274(5292):1543-7.
1996: IP Keet; PJ Veugelers; M Koot; M H de Weerd; Marijke Th L Roos; Frank Miedema; Frank de Wolf; J Goudsmit; R A Coutinho
Temporal trends of the natural history of HIV-1 infection following seroconversion between 1984 and 1993.
AIDS (London, England) 1996;10(13):1601-2.
1996: L Meyaard; R A Fouchier; Mieke C Brouwer; Egbert Hovenkamp; Frank Miedema
Syncytium-inducing HIV-1 variants replicate equally well in all types of T-helper cell clones.
AIDS (London, England) 1996;10(13):1598-600.
1996: L Meyaard; Egbert Hovenkamp; IP Keet; Berend Hooibrink; I H de Jong; Sigrid A Otto; Frank Miedema
Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2712-8.
1996: Marijke Th L Roos; Frank Miedema; A P Meinesz; N A De Leeuw; Nadine Pakker; Joep M A Lange; Roel A Coutinho; P T A Schellekens
Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: correlation with decreased CD28 expression.
Clinical and experimental immunology 1996;105(3):409-15.
1996: Katja C Wolthers; Sigrid A Otto; SM Lens; D N Kolbach; René A W van Lier; Frank Miedema; L Meyaard
Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells.
European journal of immunology 1996;26(8):1700-6.
1996: Carel A van Baalen; Michel Klein; RC Huisman; ME Dings; SR Kerkhof-Garde; AM Geretti; Rob A Gruters; Cecile Van Els; Frank Miedema; A D Osterhaus
Fine-specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1.
The Journal of general virology 1996;77 ( Pt 8)():1659-65.
1996: Frank Miedema; Michel Klein
AIDS pathogenesis: a finite immune response to blame?
Science (New York, N.Y.) 1996;272(5261):505-6.
1996: L Meyaard; Egbert Hovenkamp; Sigrid A Otto; Frank Miedema
IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2776-82.
1995: Ingrid J B Spijkerman; M Koot; Maria Prins; IP Keet; Anneke van den Hoek; Frank Miedema; Roel A Coutinho
Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men.
AIDS (London, England) 1995;9(9):1085-92.
1995: Hanneke Schuitemaker; R A Fouchier; SM Broersen; Maarten Groenink; M Koot; Angélique B van 't Wout; H G Huisman; M Tersmette; Frank Miedema
Envelope V2 configuration and HIV-1 phenotype: clarification.
Science (New York, N.Y.) 1995;268(5207):115.
1995: E Hogervorst; Suzanne Jurriaans; Frank de Wolf; Albert van Wijk; A Wiersma; M Valk; M Roos; B van Gemen; Roel A Coutinho; Frank Miedema
Predictors for non- and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels.
The Journal of infectious diseases 1995;171(4):811-21.
1995: Michel Klein; Carel A van Baalen; AM Holwerda; SR Kerkhof-Garde; Richard Bende; IP Keet; J K Eeftinck-Schattenkerk; A D Osterhaus; Hanneke Schuitemaker; Frank Miedema
Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.
The Journal of experimental medicine 1995;181(4):1365-72.
1995: Marijke Th L Roos; Frank Miedema; M Koot; M Tersmette; Wim Schaasberg; Roel A Coutinho; P T A Schellekens
T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects.
The Journal of infectious diseases 1995;171(3):531-6.
1995: Sjoerd H van der burg; Michel Klein; Cornelis J H van de Velde; W Martin Kast; Frank Miedema; Cornelis J M Melief
Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase.
AIDS (London, England) 1995;9(2):121-7.
1995: L Meyaard; Frank Miedema
Programmed death of T cells in HIV infection: result of immune activation?
Current topics in microbiology and immunology 1995;200():213-21.
1995: P T A Schellekens; M Koot; Marijke Th L Roos; M Tersmette; Frank Miedema
Immunologic and virologic markers determining progression to AIDS.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10 Suppl 2():S62-6.
1995: L Meyaard; H Kuiper; Sigrid A Otto; Katja C Wolthers; René A W van Lier; Frank Miedema
Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals.
European journal of immunology 1995;25(1):232-7.
1994: L Meyaard; Sigrid A Otto; IP Keet; René A W van Lier; Frank Miedema
Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection.
Blood 1994;84(12):4262-8.
1994: Hanneke Schuitemaker; Neeltje Kootstra; R A Fouchier; Berend Hooibrink; Frank Miedema
Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity.
The EMBO journal 1994;13(24):5929-36.
1994: Angelica B Van't Wout; Neeltje Kootstra; G A Mulder-Kampinga; N Albrecht-van Lent; H J Scherpbier; J Veenstra; kees boer; Roel A Coutinho; Frank Miedema; Hanneke Schuitemaker
Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.
The Journal of clinical investigation 1994;94(5):2060-7.
1994: L Meyaard; Sigrid A Otto; Berend Hooibrink; Frank Miedema
Quantitative analysis of CD4+ T cell function in the course of human immunodeficiency virus infection. Gradual decline of both naive and memory alloreactive T cells.
The Journal of clinical investigation 1994;94(5):1947-52.
1994: Neeltje Kootstra; Angélique B van 't Wout; H G Huisman; Frank Miedema; Hanneke Schuitemaker
Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages.
Journal of virology 1994;68(11):6967-75.
1994: IP Keet; Anneke Krol; M Koot; Marijke Th L Roos; Frank de Wolf; Frank Miedema; Roel A Coutinho
Predictors of disease progression in HIV-infected homosexual men with CD4+ cells < 200 x 10(6)/l but free of AIDS-defining clinical disease.
AIDS (London, England) 1994;8(11):1577-83.
1994: Marijke Th L Roos; N A de Leeuw; Frans A Claessen; H G Huisman; Neeltje Kootstra; L Meyaard; P T A Schellekens; Hanneke Schuitemaker; Frank Miedema
Viro-immunological studies in acute HIV-1 infection.
AIDS (London, England) 1994;8(11):1533-8.
1994: Frank Miedema; L Meyaard; M Koot; Michel Klein; Marijke Th L Roos; Maarten Groenink; R A Fouchier; Angelica B Van't Wout; M Tersmette; P T Schellekens
Changing virus-host interactions in the course of HIV-1 infection.
Immunological reviews 1994;140():35-72.
1994: Michel Klein; IP Keet; Joseph D'Amaro; Richard Bende; A Hekman; B Mesman; M Koot; L P de Waal; Roel A Coutinho; Frank Miedema
Associations between HLA frequencies and pathogenic features of human immunodeficiency virus type 1 infection in seroconverters from the Amsterdam cohort of homosexual men.
The Journal of infectious diseases 1994;169(6):1244-9.
1994: IP Keet; Anneke Krol; Michel Klein; PJ Veugelers; J de Wit; M Roos; M Koot; Jaap Goudsmit; Frank Miedema; Roel A Coutinho
Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts.
The Journal of infectious diseases 1994;169(6):1236-43.
1994: F J van Kemenade; E Tellegen; MM Maurice; A C Lankester; Taco W Kuijpers; Mieke C Brouwer; R de Jong; Frank Miedema; René A W van Lier
Simultaneous regulation of CD2 adhesion and signaling functions by a novel CD2 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4425-32.
1994: L Meyaard; Sigrid A Otto; IP Keet; Marijke Th L Roos; Frank Miedema
Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.
The Journal of clinical investigation 1994;93(3):982-8.
1994: G H Mientjes; Frank Miedema; J A R van den Hoek; Roel A Coutinho
Immunologic alterations in splenectomized HIV-infected intravenous drug users.
AIDS (London, England) 1994;8(2):269-71.
1994: Hanneke Schuitemaker; M Koot; Frank Miedema
Recent development on research in AIDS pathogenesis.
Vox sanguinis 1994;67 Suppl 3():133-6.
1993: Hanneke Schuitemaker; L Meyaard; Neeltje Kootstra; R Dubbes; Sigrid A Otto; M Tersmette; Jonathan Luke Heeney; Frank Miedema
Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants.
The Journal of infectious diseases 1993;168(5):1140-7.
1993: G H Mientjes; Erik J C van Ameijden; Anneke van den Hoek; Jaap Goudsmit; Frank Miedema; Roel A Coutinho
Progression of HIV infection among injecting drug users: indications for a lower rate of progression among those who have frequently borrowed injecting equipment.
AIDS (London, England) 1993;7(10):1363-70.
1993: M Koot; P T A Schellekens; J W Mulder; Joep M A Lange; Marijke Th L Roos; Roel A Coutinho; M Tersmette; Frank Miedema
Viral phenotype and T cell reactivity in human immunodeficiency virus type 1-infected asymptomatic men treated with zidovudine.
The Journal of infectious diseases 1993;168(3):733-6.
1993: Hanneke Schuitemaker; Maarten Groenink; L Meyaard; Neeltje Kootstra; R A Fouchier; Rob A Gruters; H G Huisman; M Tersmette; Frank Miedema
Early replication steps but not cell type-specific signalling of the viral long terminal repeat determine HIV-1 monocytotropism.
AIDS research and human retroviruses 1993;9(7):669-75.
1993: Maarten Groenink; R A Fouchier; SM Broersen; C H Baker; M Koot; Angelica B Van't Wout; H G Huisman; Frank Miedema; M Tersmette; Hanneke Schuitemaker
Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
Science (New York, N.Y.) 1993;260(5113):1513-6.
1993: Carel A van Baalen; Michel Klein; AM Geretti; R I Keet; Frank Miedema; Cecile Van Els; A D Osterhaus
Selective in vitro expansion of HLA class I-restricted HIV-1 Gag-specific CD8+ T cells: cytotoxic T-lymphocyte epitopes and precursor frequencies.
AIDS (London, England) 1993;7(6):781-6.
1993: M Koot; IP Keet; A H Vos; R E de Goede; Marijke Th L Roos; Roel A Coutinho; Frank Miedema; P T A Schellekens; M Tersmette
Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.
Annals of internal medicine 1993;118(9):681-8.
1993: L Meyaard; Hanneke Schuitemaker; Frank Miedema
T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?
Immunology today 1993;14(4):161-4.
1993: F J van Kemenade; K C Kuijpers; R de Waal-Malefijt; René A W van Lier; Frank Miedema
Skewing to the LFA-3 adhesion pathway by influenza infection of antigen-presenting cells.
European journal of immunology 1993;23(3):635-9.
1993: H Schuitemaker; Maarten Groenink; M Tersmette; Frank Miedema
HIV tropism.
Nature 1993;361(6410):310.
1993: IP Keet; P Krijnen; M Koot; Joep M A Lange; Frank Miedema; Jaap Goudsmit; Roel A Coutinho
Predictors of rapid progression to AIDS in HIV-1 seroconverters.
AIDS (London, England) 1993;7(1):51-7.
1992: G H Mientjes; Erik J C van Ameijden; Marijke Th L Roos; N A de Leeuw; J A R van den Hoek; Roel A Coutinho; Frank Miedema
Large diurnal variation in CD4 cell count and T-cell function among drug users: implications for clinical practice and epidemiological studies.
AIDS (London, England) 1992;6(11):1269-72.
1992: Charles A B Boucher; Joep M A Lange; Frank Miedema; Gerrit Jan Weverling; M Koot; Jan W Mulder; Jaap Goudsmit; Kellam Paul; Brendan Larder; M Tersmette
HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment.
AIDS (London, England) 1992;6(11):1259-64.
1992: R de Jong; Mieke C Brouwer; H M Kuiper; Berend Hooibrink; Frank Miedema; René A W van Lier
Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2795-802.
1992: L Meyaard; Sigrid A Otto; Hanneke Schuitemaker; Frank Miedema
Effects of HIV-1 Tat protein on human T cell proliferation.
European journal of immunology 1992;22(10):2729-32.
1992: K C Kuijpers; F J van Kemenade; Berend Hooibrink; Jacques Neefjes; C J Lucas; René A W van Lier; Frank Miedema
HLA class I and II molecules present influenza virus antigens with different kinetics.
European journal of immunology 1992;22(9):2339-45.
1992: Hanneke Schuitemaker; Neeltje Kootstra; Maarten Groenink; R E De Goede; Frank Miedema; M Tersmette
Differential tropism of clinical HIV-1 isolates for primary monocytes and promonocytic cell lines.
AIDS research and human retroviruses 1992;8(9):1679-82.
1992: L Meyaard; Sigrid A Otto; R R Jonker; M J Mijnster; R P Keet; Frank Miedema
Programmed death of T cells in HIV-1 infection.
Science (New York, N.Y.) 1992;257(5067):217-9.
1992: P T A Schellekens; M Tersmette; Marijke Th L Roos; R P Keet; Frank de Wolf; Roel A Coutinho; Frank Miedema
Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype.
AIDS (London, England) 1992;6(7):665-9.
1992: R A Fouchier; Maarten Groenink; Neeltje Kootstra; M Tersmette; H G Huisman; Frank Miedema; Hanneke Schuitemaker
Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.
Journal of virology 1992;66(5):3183-7.
1992: Hanneke Schuitemaker; Neeltje Kootstra; M H Koppelman; Sylvia M Bruisten; H G Huisman; M Tersmette; Frank Miedema
Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages.
The Journal of clinical investigation 1992;89(4):1154-60.
1992: R De Jong; Mieke C Brouwer; Berend Hooibrink; T Van der Pouw-Kraan; Frank Miedema; René A W van Lier
The CD27- subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo.
European journal of immunology 1992;22(4):993-9.
1992: Hanneke Schuitemaker; M Koot; Neeltje Kootstra; M W Dercksen; R E de Goede; R P van Steenwijk; Joep M A Lange; J K Schattenkerk; Frank Miedema; M Tersmette
Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.
Journal of virology 1992;66(3):1354-60.
1992: Marijke Th L Roos; Joep M A Lange; R E de Goede; Roel A Coutinho; P T A Schellekens; Frank Miedema; M Tersmette
Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection.
The Journal of infectious diseases 1992;165(3):427-32.
1992: M Koot; A H Vos; R P Keet; R E de Goede; M W Dercksen; F G Terpstra; Roel A Coutinho; Frank Miedema; M Tersmette
HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay.
AIDS (London, England) 1992;6(1):49-54.
1992: Frank Miedema
Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance.
Immunodeficiency reviews 1992;3(3):173-93.
1991: R de Jong; P Stokkers; Evert Lamme; J M Kool; F Borst; Mieke C Brouwer; Frank Miedema; René A W van Lier
Regulation of T-cell differentiation by CD2 and CD28 accessory molecules.
Immunology 1991;74(2):175-82.
1991: Rob A Gruters; F G Terpstra; R E De Goede; J W Mulder; Frank de Wolf; P T A Schellekens; René A W van Lier; M Tersmette; Frank Miedema
Immunological and virological markers in individuals progressing from seroconversion to AIDS.
AIDS (London, England) 1991;5(7):837-44.
1991: K C Kuijpers; P Treep-Van Leeuwen; Frank Miedema; C J Lucas
Allo-cross-reactivity of a human neuraminidase-specific T cell clone dependent on presentation of an endogenous B cell-specific antigen.
European journal of immunology 1991;21(6):1453-60.
1991: R de Jong; Mieke C Brouwer; Frank Miedema; René A W van Lier
Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2088-94.
1991: Hanneke Schuitemaker; Neeltje Kootstra; R E de Goede; Frank de Wolf; Frank Miedema; M Tersmette
Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.
Journal of virology 1991;65(1):356-63.
1991: Rob A Gruters; S A Otto; B J Al; Arthur J Verhoeven; Cornelis L Verweij; René A W van Lier; Frank Miedema
Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription.
European journal of immunology 1991;21(1):167-72.
1991: G H Mientjes; Frank Miedema; Erik J C van Ameijden; Anneke van den Hoek; P T Schellekens; Marijke Th L Roos; Roel A Coutinho
Frequent injecting impairs lymphocyte reactivity in HIV-positive and HIV-negative drug users.
AIDS (London, England) 1991;5(1):35-41.
1991: Rob A Gruters; F G Terpstra; Joep M A Lange; Marijke Th L Roos; T Harkema; J W Mulder; Frank de Wolf; P T A Schellekens; Frank Miedema
Differences in clinical course in zidovudine-treated asymptomatic HIV-infected men associated with T-cell function at intake.
AIDS (London, England) 1991;5(1):43-7.
1990: Hanneke Schuitemaker; Neeltje Kootstra; Marinus H J van Oers; R van Lambalgen; M Tersmette; Frank Miedema
Induction of monocyte proliferation and HIV expression by IL-3 does not interfere with anti-viral activity of zidovudine.
Blood 1990;76(8):1490-3.
1990: R De Jong; Mieke C Brouwer; Vivienne Rebel; Gijs A van Seventer; Frank Miedema; René A W van Lier
Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation.
Immunology 1990;70(3):357-64.
1990: Carel J M van Noesel; Rob A Gruters; F G Terpstra; P T A Schellekens; René A W van Lier; Frank Miedema
Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.
The Journal of clinical investigation 1990;86(1):293-9.
1990: Rob A Gruters; F G Terpstra; R De Jong; Carel J M van Noesel; René A W van Lier; Frank Miedema
Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.
European journal of immunology 1990;20(5):1039-44.
1990: K C Kuijpers; Taco W Kuijpers; W P Zeijlemaker; C J Lucas; René A W van Lier; Frank Miedema
Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3281-7.
1990: P T A Schellekens; Marijke Th L Roos; Frank de Wolf; Joep M A Lange; Frank Miedema
Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men.
Journal of clinical immunology 1990;10(2):121-7.
1990: M Tersmette; Frank Miedema
Interactions between HIV and the host immune system in the pathogenesis of AIDS.
AIDS (London, England) 1990;4 Suppl 1():S57-66.
1989: M Tersmette; I N Winkel; Maarten Groenink; Rob A Gruters; R P Spence; E Saman; G Van Der Groen; Frank Miedema; J G Huisman
Detection and subtyping of HIV-1 isolates with a panel of characterized monoclonal antibodies to HIV p24gag.
Virology 1989;171(1):149-55.
1989: M Tersmette; Rob A Gruters; Frank de Wolf; R E de Goede; Joep M A Lange; P T A Schellekens; Jaap Goudsmit; H G Huisman; Frank Miedema
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
Journal of virology 1989;63(5):2118-25.
1989: F G Terpstra; B J Al; Marijke Th L Roos; Frank de Wolf; Jaap Goudsmit; P T A Schellekens; Frank Miedema
Longitudinal study of leukocyte functions in homosexual men seroconverted for HIV: rapid and persistent loss of B cell function after HIV infection.
European journal of immunology 1989;19(4):667-73.
1989: M Tersmette; J J van Dongen; P R Clapham; R E de Goede; I L Wolvers-Tettero; A Geurts van Kessel; J G Huisman; R A Weiss; Frank Miedema
Human immunodeficiency virus infection studied in CD4-expressing human-murine T-cell hybrids.
Virology 1989;168(2):267-73.
1988: Frank Miedema; A J Petit; F G Terpstra; J K Schattenkerk; Frank de Wolf; B J Al; M Roos; Joep M A Lange; Sven A Danner; Jaap Goudsmit
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.
The Journal of clinical investigation 1988;82(6):1908-14.
1988: F T Rotteveel; I Kokkelink; René A W van Lier; B Kuenen; A Meager; Frank Miedema; C J Lucas
Clonal analysis of functionally distinct human CD4+ T cell subsets.
The Journal of experimental medicine 1988;168(5):1659-73.
1988: R W Sauerwein; Menno A de Rie; W G van der Meer; Frank Miedema; Lucien A Aarden
Regulation of malignant B-cell proliferation by direct binding of anti-HLA class-II antibodies.
Cellular immunology 1988;114(2):424-31.
1988: Carel J M van Noesel; Frank Miedema; Mieke C Brouwer; Menno A de Rie; Lucien A Aarden; René A W van Lier
Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation.
Nature 1988;333(6176):850-2.
1988: M Tersmette; R E de Goede; B J Al; I N Winkel; Rob A Gruters; H Theo M Cuypers; H G Huisman; Frank Miedema
Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.
Journal of virology 1988;62(6):2026-32.
1988: René A W van Lier; M O Pool; P Kabel; S Mous; F Terpstra; Menno A de Rie; Cornelis J M Melief; Frank Miedema
Anti-CD27 monoclonal antibodies identify two functionally distinct subpopulations within the CD4+ T cell subset.
European journal of immunology 1988;18(5):811-6.
1988: A J Petit; M Tersmette; F G Terpstra; R E de Goede; René A W van Lier; Frank Miedema
Decreased accessory cell function by human monocytic cells after infection with HIV.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1485-9.
1988: R W Sauerwein; W G Van der Meer; J W Van Oostveen; Frank Miedema; Lucien A Aarden
Anti-CD3 antibodies induce T helper function for human B cell differentiation in vitro by an interleukin 2-independent pathway.
European journal of immunology 1988;18(1):133-7.
1988: M Tersmette; P Nico Lelie; Cees L van der Poel; M R Wester; R E de Goede; Joep M A Lange; Frank Miedema; J G Huisman
Confirmation of HIV seropositivity: comparison of a novel radioimmunoprecipitation assay to immunoblotting and virus culture.
Journal of medical virology 1988;24(1):109-16.
1987: Rob A Gruters; Jacques Neefjes; M Tersmette; R E de Goede; A Tulp; H G Huisman; Frank Miedema; Hidde L Ploegh
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Nature 1987;330(6143):74-7.
1987: Menno A de Rie; P Kabel; R W Sauerwein; R A Van Lier; A E Von dem Borne; C J Melief; Frank Miedema
Anti-HLA-class II monoclonal antibodies inhibit polyclonal B cell differentiation in vitro at the accessory cell level.
European journal of immunology 1987;17(6):881-6.
1987: A J Petit; F G Terpstra; Frank Miedema
Human immunodeficiency virus infection down-regulates HLA class II expression and induces differentiation in promonocytic U937 cells.
The Journal of clinical investigation 1987;79(6):1883-9.
1987: J G Huisman; I N Winkel; P Nico Lelie; M Tersmette; J Goudsmit; Frank Miedema
Detection of early anti-p24 HIV responses in EIA- and immunoblot-negative individuals. Implications for confirmatory testing.
Vox sanguinis 1987;53(1):31-6.
1986: Jaap Goudsmit; Frank Miedema; C Breederveld; F Terpstra; M Roos; P Schellekens; Cornelis J M Melief
Antibodies to the human T-cell lymphoma/leukemia virus type I in Dutch haemophiliacs.
Vox sanguinis 1986;50(1):12-5.
1985: Frank Miedema; J W van Oostveen; F G Terpstra; A W van den Wall Bake; R Willemze; E A Rauws; R Bieger; M B van 't Veer; D Catovsky; C J Melief
Analysis of helper activity on pokeweed mitogen- and interleukin 2-driven immunoglobulin synthesis by neoplastic T4+ cells.
The Journal of clinical investigation 1985;76(6):2139-43.
1985: Frank Miedema; F G Terpstra; Jan W Smit; J P van der Veen; Cornelis J M Melief
T gamma lymphocytosis is clinically non-progressive but immunologically heterogeneous.
Clinical and experimental immunology 1985;61(2):440-9.
1985: Frank Miedema; P A Tetteroo; F G Terpstra; G Keizer; M Roos; R S Weening; C M Weemaes; D Roos; Cornelis J M Melief
Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(5):3075-81.
1985: Frank Miedema; J W Van Oostveen; R W Sauerwein; F G Terpstra; Lucien A Aarden; C J Melief
Induction of immunoglobulin synthesis by interleukin 2 is T4+/T8- cell dependent. A role for interleukin 2 in the pokeweed mitogen-driven system.
European journal of immunology 1985;15(2):107-12.
1984: Frank Miedema; F G Terpstra; Jan W Smit; S M G J Daenen; W Gerrits; U Hegde; E Matutes; D Catovsky; M F Greaves; Cornelis J M Melief
Functional properties of neoplastic T cells in adult T cell lymphoma/leukemia patients from the Caribbean.
Blood 1984;63(2):477-81.
1982: H C Rümke; Frank Miedema; I J ten Berge; F Terpstra; H J van der Reijden; R J van de Griend; H G de Bruin; A E von dem Borne; J W Smit; W P Zeijlemaker; Cornelis J M Melief
Functional properties of T cells in patients with chronic T gamma lymphocytosis and chronic T cell neoplasia.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(1):419-26.