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Thorsten Mielke

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Ribosomes

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David J F Ramrath; Kristian Rother; Patrick Scheerer; Olga V Shpanchenko; Pavel Ivanov; Justus Loerke; Thorsten Mielke; Knud H Nierhaus; Markus Pech; Yoshika Teraoka; Daniela Wittek; Hiroshi Yamamoto; Christian M T Spahn
The complex of tmRNA-SmpB and EF-G on translocating ribosomes.
Tatyana Budkevich; Jan Giesebrecht; Thorsten Mielke; James B Munro; Knud H Nierhaus; Roger B Altman; Scott C Blanchard; Christian M T Spahn
Structure and dynamics of the mammalian ribosomal pretranslocation complex.
Margarita Muhs; Nobuhiko Nakashima; Masayuki Nashimoto; Knud H Nierhaus; Peter W Hildebrand; Jochen Ismer; Thorsten Mielke; Hiroaki Takaku; Toshio Uchiumi; Hiroshi Yamamoto; Christian M T Spahn
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit.

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All Publications

2012: David J F Ramrath; Kristian Rother; Patrick Scheerer; Olga V Shpanchenko; Pavel Ivanov; Justus Loerke; Thorsten Mielke; Knud H Nierhaus; Markus Pech; Yoshika Teraoka; Daniela Wittek; Hiroshi Yamamoto; Christian M T Spahn
The complex of tmRNA-SmpB and EF-G on translocating ribosomes.
Nature 2012;485(7399):526-9.
2011: Tatyana Budkevich; Jan Giesebrecht; Thorsten Mielke; James B Munro; Knud H Nierhaus; Roger B Altman; Scott C Blanchard; Christian M T Spahn
Structure and dynamics of the mammalian ribosomal pretranslocation complex.
Molecular cell 2011;44(2):214-24.
2011: Margarita Muhs; Nobuhiko Nakashima; Masayuki Nashimoto; Knud H Nierhaus; Peter W Hildebrand; Jochen Ismer; Thorsten Mielke; Hiroaki Takaku; Toshio Uchiumi; Hiroshi Yamamoto; Christian M T Spahn
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit.
Nucleic acids research 2011;39(12):5264-75.
2011: Thomas Becker; Jean-Paul Armache; Alexander Jarasch; Andreas M Anger; Elizabeth Villa; Heidemarie Sieber; Basma Abdel Motaal; Thorsten Mielke; Otto Berninghausen; Roland Beckmann
Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.
Nature structural & molecular biology 2011;18(6):715-20.
2011: Jens Frauenfeld; James Gumbart; Eli O van der Sluis; Soledad Funes; Marco Gartmann; Birgitta Beatrix; Thorsten Mielke; Otto Berninghausen; Thomas Becker; Klaus Schulten; Roland Beckmann
Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.
Nature structural & molecular biology 2011;18(5):614-21.
2011: Elmar Czeko; Martin Seizl; Christian Augsberger; Thorsten Mielke; Patrick Cramer
Iwr1 directs RNA polymerase II nuclear import.
Molecular cell 2011;42(2):261-6.
2011: Shashi Bhushan; Thomas Hoffmann; Birgit Seidelt; Jens Frauenfeld; Thorsten Mielke; Otto Berninghausen; Daniel N Wilson; Roland Beckmann
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.
PLoS biology 2011;9(1):e1000581.
2010: Andreas H Ratje; Justus Loerke; Aleksandra Mikolajka; Matthias Brünner; Peter W Hildebrand; Agata L Starosta; Alexandra Dönhöfer; Sean connell; Paola Fucini; Thorsten Mielke; Paul C Whitford; José N Onuchic; Yanan Yu; Karissa Y Sanbonmatsu; Roland K Hartmann; Pawel A Penczek; Daniel N Wilson; Christian M T Spahn
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.
Nature 2010;468(7324):713-6.
2010: Jean-Paul Armache; Alexander Jarasch; Andreas M Anger; Elizabeth Villa; Thomas Becker; Shashi Bhushan; Fabrice Jossinet; Michael Habeck; Gülcin Dindar; Sibylle Franckenberg; Viter Marquez; Thorsten Mielke; Michael Thomm; Otto Berninghausen; Birgitta Beatrix; Johannes Söding; Eric Westhof; Daniel N Wilson; Roland Beckmann
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19748-53.
2010: Jean-Paul Armache; Alexander Jarasch; Andreas M Anger; Elizabeth Villa; Thomas Becker; Shashi Bhushan; Fabrice Jossinet; Michael Habeck; Gülcin Dindar; Sibylle Franckenberg; Viter Marquez; Thorsten Mielke; Michael Thomm; Otto Berninghausen; Birgitta Beatrix; Johannes Söding; Eric Westhof; Daniel N Wilson; Roland Beckmann
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19754-9.
2010: Shashi Bhushan; Helge Meyer; Agata Starosta; Thomas Becker; Thorsten Mielke; Otto Berninghausen; Michael Sattler; Daniel N Wilson; Roland Beckmann
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.
Molecular cell 2010;40(1):138-46.
2010: Marco Gartmann; Michael Blau; Jean-Paul Armache; Thorsten Mielke; Maya Topf; Roland Beckmann
Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.
The Journal of biological chemistry 2010;285(20):14848-51.
2010: Shashi Bhushan; Marco Gartmann; Mario Halic; Jean-Paul Armache; Alexander Jarasch; Thorsten Mielke; Otto Berninghausen; Daniel N Wilson; Roland Beckmann
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.
Nature structural & molecular biology 2010;17(3):313-7.
2009: Birgit Seidelt; C Axel Innis; Daniel N Wilson; Marco Gartmann; Jean-Paul Armache; Elizabeth Villa; Leonardo G Trabuco; Thomas Becker; Thorsten Mielke; Klaus Schulten; Thomas A Steitz; Roland Beckmann
Structural insight into nascent polypeptide chain-mediated translational stalling.
Science (New York, N.Y.) 2009;326(5958):1412-5.
2009: Thomas Becker; Shashi Bhushan; Alexander Jarasch; Jean-Paul Armache; Soledad Funes; Fabrice Jossinet; James Gumbart; Thorsten Mielke; Otto Berninghausen; Klaus Schulten; Eric Westhof; Reid Gilmore; Elisabet C Mandon; Roland Beckmann
Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome.
Science (New York, N.Y.) 2009;326(5958):1369-73.
2009: Jan-Christian Schuette; Frank Murphy; Ann C Kelley; John R Weir; Jan Giesebrecht; Sean connell; Justus Loerke; Thorsten Mielke; Wei Zhang; Pawel A Penczek; V Ramakrishnan; Christian M T Spahn
GTPase activation of elongation factor EF-Tu by the ribosome during decoding.
The EMBO journal 2009;28(6):755-65.
2008: Sean connell; Maya Topf; Yan Qin; Daniel N Wilson; Thorsten Mielke; Paola Fucini; Knud H Nierhaus; Christian M T Spahn
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.
Nature structural & molecular biology 2008;15(9):910-5.
2008: James Z Chen; Carsten Sachse; Chen Xu; Thorsten Mielke; Christian M T Spahn; Nikolaus Grigorieff
A dose-rate effect in single-particle electron microscopy.
Journal of structural biology 2008;161(1):92-100.
2007: Claus-D Kuhn; Sebastian R Geiger; Sonja Baumli; Marco Gartmann; Jochen Gerber; Stefan Jennebach; Thorsten Mielke; Herbert Tschochner; Roland Beckmann; Patrick Cramer
Functional architecture of RNA polymerase I.
Cell 2007;131(7):1260-72.
2007: Sean connell; Chie Takemoto; Daniel N Wilson; Hongfei Wang; Kazutaka Murayama; Takaho Terada; Mikako Shirouzu; Maximilian Rost; Martin Schüler; Jan Giesebrecht; Marylena Dabrowski; Thorsten Mielke; Paola Fucini; Shigeyuki Yokoyama; Christian M T Spahn
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.
Molecular cell 2007;25(5):751-64.
2006: Martin Schüler; Sean connell; Aurélie Lescoute; Jan Giesebrecht; Marylena Dabrowski; Birgit Schroeer; Thorsten Mielke; Pawel A Penczek; Eric Westhof; Christian M T Spahn
Structure of the ribosome-bound cricket paralysis virus IRES RNA.
Nature structural & molecular biology 2006;13(12):1092-6.
2006: Mario Halic; Michael Blau; Thomas Becker; Thorsten Mielke; Martin R Pool; Klemens Wild; Irmgard Sinning; Roland Beckmann
Following the signal sequence from ribosomal tunnel exit to signal recognition particle.
Nature 2006;444(7118):507-11.
2006: Christian B F Andersen; Thomas Becker; Michael Blau; Monika Anand; Mario Halic; Bharvi Balar; Thorsten Mielke; Thomas Boesen; Jan Skov Pedersen; Christian M T Spahn; Terri Goss Kinzy; Gregers R Andersen; Roland Beckmann
Structure of eEF3 and the mechanism of transfer RNA release from the E-site.
Nature 2006;443(7112):663-8.
2006: Mario Halic; Marco Gartmann; Oliver Schlenker; Thorsten Mielke; Martin R Pool; Irmgard Sinning; Roland Beckmann
Signal recognition particle receptor exposes the ribosomal translocon binding site.
Science (New York, N.Y.) 2006;312(5774):745-7.