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Jeffrey Milbrandt

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Andreu Viader; Cayce S Workman; Kui Yang; Richard W Gross; Sungsu Kim; Yo Sasaki; Amy Strickland; Jeffrey Milbrandt
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Li-Wei Chang; Jeffrey Milbrandt; Jacqueline E Payton; Nobish Varghese; Andreu Viader; Rakesh Nagarajan
An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.
Jung Eun Shin; Elisabetta Babetto; Valeria Cavalli; Yongcheol Cho; Jeffrey Milbrandt; Bradley R Miller; Shehzad Qayum; Emilie V Russler; Yo Sasaki; Aaron DiAntonio
SCG10 is a JNK target in the axonal degeneration pathway.

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All Publications

2013: Andreu Viader; Cayce S Workman; Kui Yang; Richard W Gross; Sungsu Kim; Yo Sasaki; Amy Strickland; Jeffrey Milbrandt
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Neuron 2013;77(5):886-98.
2013: Li-Wei Chang; Jeffrey Milbrandt; Jacqueline E Payton; Nobish Varghese; Andreu Viader; Rakesh Nagarajan
An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.
BMC genomics 2013;14():84.
2012: Jung Eun Shin; Elisabetta Babetto; Valeria Cavalli; Yongcheol Cho; Jeffrey Milbrandt; Bradley R Miller; Shehzad Qayum; Emilie V Russler; Yo Sasaki; Aaron DiAntonio
SCG10 is a JNK target in the axonal degeneration pathway.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):E3696-705.
2012: Jung Eun Shin; Jeffrey Milbrandt; Bogdan Beirowski; Valeria Cavalli; Yongcheol Cho; Aaron DiAntonio
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.
Neuron 2012;74(6):1015-22.
2012: Martha R C Bhattacharya; Sarah Y Ebstein; Josiah Gerdts; Jeffrey Milbrandt; Sarah A Naylor; Emily X Royse; Yo Sasaki; Aaron DiAntonio
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(15):5054-61.
2011: Andreu Viader; Rakesh Nagarajan; Li-Wei Chang; Timothy Fahrner; Jeffrey Milbrandt
MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(48):17358-69.
2011: Philip B Verghese; Christine M Wroge; Donghan Yang; Mary Beth Finn; Steven Mennerick; Jeffrey Milbrandt; Jeffrey J Neil; Fatima Sabar; Yo Sasaki; Floy Stewart; David M Holtzman
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):19054-9.
2011: Bogdan Beirowski; Judith P Golden; Jason Gustin; Shaday Michan; Brian J North; Robert E Schmidt; David A Sinclair; Andreu Viader; Hiroyasu Yamamoto; Sean M Armour; Johan Auwerx; Robert H Baloh; Jeffrey Milbrandt
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):E952-61.
2011: Andreu Viader; Bhupinder P S Vohra; Elizabeth C Wright-Jin; Robert O. Heuckeroth; Jeffrey Milbrandt
Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.
PloS one 2011;6(11):e27727.
2010: Yo Sasaki; Jeffrey Milbrandt
Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.
The Journal of biological chemistry 2010;285(53):41211-5.
2010: Jufang Chang; Bin Zhang; Helen Heath; Niels Galjart; X Wang; Jeffrey Milbrandt
Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21836-41.
2010: Bhupinder P S Vohra; Yo Sasaki; Bradley R Miller; Jufang Chang; Aaron DiAntonio; Jeffrey Milbrandt
Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13729-38.
2010: Megan M Kaneda; Yo Sasaki; Gregory M Lanza; Jeffrey Milbrandt; Samuel A Wickline
Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions.
Biomaterials 2010;31(11):3079-86.
2010: Albert Misko; Sirui Jiang; Iga Wegorzewska; Jeffrey Milbrandt; Robert H Baloh
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(12):4232-40.
2010: Judith P Golden; Masato Hoshi; Mohammed A Nassar; Hideki Enomoto; John N Wood; Jeffrey Milbrandt; Robert W Gereau; Eugene M Johnson; Sanjay Jain
RET signaling is required for survival and normal function of nonpeptidergic nociceptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):3983-94.
2009: H Song; B Zhang; Mark A Watson; Peter A Humphrey; H Lim; Jeffrey Milbrandt
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.
Oncogene 2009;28(37):3307-19.
2009: Jufang Chang; Robert H Baloh; Jeffrey Milbrandt
The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.
Journal of cell science 2009;122(Pt 13):2274-82.
2009: Yo Sasaki; Bhupinder P S Vohra; Robert H Baloh; Jeffrey Milbrandt
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(20):6526-34.
2009: Yo Sasaki; Bhupinder P S Vohra; Frances E Lund; Jeffrey Milbrandt
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(17):5525-35.
2009: Craig Press; Jeffrey Milbrandt
The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro.
Journal of neurochemistry 2009;109(2):595-602.
2009: Biplab Dasgupta; Jeffrey Milbrandt
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
Developmental cell 2009;16(2):256-70.
2009: Bin Zhang; Jufang Chang; Ming Fu; Jie Huang; Rakesh Kashyap; Ezequiel Salavaggione; Sanjay Jain; Shashikant Kulkarni; Kulkarni Shashikant; Matthew A Deardorff; Maria L Giovannucci Uzielli; Dale Dorsett; David C Beebe; Patrick Y Jay; Robert O. Heuckeroth; Ian Krantz; Jeffrey Milbrandt
Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
PloS one 2009;4(5):e5232.
2008: Elizabeth J Ryu; Mao Yang; Jason A Gustin; Li-Wei Chang; Robert R Freimuth; Rakesh Nagarajan; Jeffrey Milbrandt
Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(30):7563-73.
2008: Yucui Chen; Beth Stevens; Jufang Chang; Jeffrey Milbrandt; Ben A Barres; Johannes Hell
NS21: re-defined and modified supplement B27 for neuronal cultures.
Journal of neuroscience methods 2008;171(2):239-47.
2008: Craig Press; Jeffrey Milbrandt
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(19):4861-71.
2008: Amelia Gallitano-Mendel; David F Wozniak; Elizabeth A Pehek; Jeffrey Milbrandt
Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(6):1266-75.
2008: Milam A Brantley; Sanjay Jain; Emily E Barr; Eugene M Johnson; Jeffrey Milbrandt
Neurturin-mediated ret activation is required for retinal function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4123-35.
2007: Javier R Revollo; Antje Körner; Kathryn F Mills; Akiko Satoh; Tao Wang; Antje Garten; Biplab Dasgupta; Yo Sasaki; Cynthia Wolberger; R Reid Townsend; Jeffrey Milbrandt; Wieland Kiess; Shinichiro Imai
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
Cell metabolism 2007;6(5):363-75.
2007: Elizabeth J Ryu; James Y T Wang; Nam Le; Robert H Baloh; Jason A Gustin; Robert E Schmidt; Jeffrey Milbrandt
Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(43):11552-9.
2007: Bin Zhang; Sanjay Jain; Haengseok Song; Ming Fu; Robert O. Heuckeroth; Jonathan M Erlich; Patrick Y Jay; Jeffrey Milbrandt
Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
Development (Cambridge, England) 2007;134(17):3191-201.
2007: Jason A Gustin; Mao Yang; Eugene M Johnson; Jeffrey Milbrandt
Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.
Journal of neurochemistry 2007;102(4):1184-94.
2007: Robert H Baloh; Ezequiel Salavaggione; Jeffrey Milbrandt; Alan Pestronk
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Archives of neurology 2007;64(7):998-1000.
2007: Shannon E Mullican; Shuo Zhang; Marina Konopleva; Vivian Ruvolo; Michael Andreeff; Jeffrey Milbrandt; Orla M Conneely
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.
Nature medicine 2007;13(6):730-5.
2007: Robert H Baloh; Robert E Schmidt; Alan Pestronk; Jeffrey Milbrandt
Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(2):422-30.
2006: Brian A Pierchala; Jeffrey Milbrandt; Eugene M Johnson
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(10):2777-87.
2006: Li-Wei Chang; Rakesh Nagarajan; Jeffrey A Magee; Jeffrey Milbrandt; Gary stormo
A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.
Genome research 2006;16(3):405-13.
2006: Cathy K Naughton; Sanjay Jain; Amy Strickland; Akshay Gupta; Jeffrey Milbrandt
Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate.
Biology of reproduction 2006;74(2):314-21.
2006: Jeffrey A Magee; Li-Wei Chang; Gary stormo; Jeffrey Milbrandt
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.
Endocrinology 2006;147(1):590-8.
2005: Shanelle W Ko; Amelia Gallitano Mendel; Jeffrey Milbrandt; Chang-Shen Qiu; Feng Wei; Hu-Shan Ao; Min Zhuo
Transcription factor Egr-1 is required for long-term fear memory and anxiety.
Sheng li xue bao : [Acta physiologica Sinica] 2005;57(4):421-32.
2005: Nam Le; Rakesh Nagarajan; James Y T Wang; John Svaren; Christine M LaPash Daniels; Toshiyuki Araki; Robert E Schmidt; Jeffrey Milbrandt
Nab proteins are essential for peripheral nervous system myelination.
Nature neuroscience 2005;8(7):932-40.
2005: Nam Le; Rakesh Nagarajan; James Y T Wang; Toshiyuki Araki; Robert E Schmidt; Jeffrey Milbrandt
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2596-601.
2005: Melanie L Leitner; Leo H Wang; Patricia A Osborne; Judith P Golden; Jeffrey Milbrandt; Eugene M Johnson
Expression and function of GDNF family ligands and receptors in the carotid body.
Experimental neurology 2005;191 Suppl 1():S68-79.
2004: Hideki Enomoto; Inna Hughes; Judith Golden; Robert H Baloh; Shigenobu Yonemura; Robert O. Heuckeroth; Eugene M Johnson; Jeffrey Milbrandt
GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration.
Neuron 2004;44(4):623-36.
2004: Sanjay Jain; Cathy K Naughton; Mao Yang; Amy Strickland; Kiran Vij; Mario Encinas; Judy Golden; Akshay Gupta; Robert O. Heuckeroth; Eugene M Johnson; Jeffrey Milbrandt
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.
Development (Cambridge, England) 2004;131(21):5503-13.
2004: Robert J Crowder; Hideki Enomoto; Mao Yang; Eugene M Johnson; Jeffrey Milbrandt
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
The Journal of biological chemistry 2004;279(40):42072-81.
2004: Toshiyuki Araki; Yo Sasaki; Jeffrey Milbrandt
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
Science (New York, N.Y.) 2004;305(5686):1010-3.
2004: Sanjay Jain; Mark A Watson; Mary K DeBenedetti; Yuji Hiraki; Jeffrey F Moley; Jeffrey Milbrandt
Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors.
Cancer research 2004;64(11):3907-13.
2004: Mario Encinas; Robert J Crowder; Jeffrey Milbrandt; Eugene M Johnson
Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival.
The Journal of biological chemistry 2004;279(18):18262-9.
2003: Judith P Golden; Jeffrey Milbrandt; Eugene M Johnson
Neurturin and persephin promote the survival of embryonic basal forebrain cholinergic neurons in vitro.
Experimental neurology 2003;184(1):447-55.
2003: Toshiyuki Araki; Jeffrey Milbrandt
ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9385-94.
2003: Xiu Jun Song; De-Quan Li; William Farley; Li Hui Luo; Robert O. Heuckeroth; Jeffrey Milbrandt; Stephen C Pflugfelder
Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca.
Investigative ophthalmology & visual science 2003;44(10):4223-9.
2003: Jeffrey A Magee; Sarki A Abdulkadir; Jeffrey Milbrandt
Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation.
Cancer cell 2003;3(3):273-83.
2003: Mark Clements; Dianne Duncan; Jeffrey Milbrandt
Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.
Developmental dynamics : an official publication of the American Association of Anatomists 2003;226(1):67-81.
2002: Vijayanand Modur; Rakesh Nagarajan; B Mark Evers; Jeffrey Milbrandt
FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.
The Journal of biological chemistry 2002;277(49):47928-37.
2002: Brian A Tsui-Pierchala; Rebecca C Ahrens; Robert J Crowder; Jeffrey Milbrandt; Eugene M Johnson
The long and short isoforms of Ret function as independent signaling complexes.
The Journal of biological chemistry 2002;277(37):34618-25.
2002: Brian A Tsui-Pierchala; Mario Encinas; Jeffrey Milbrandt; Eugene M Johnson
Lipid rafts in neuronal signaling and function.
Trends in neurosciences 2002;25(8):412-7.
2002: Yutaka Honma; Toshiyuki Araki; Scott Gianino; Allen Bruce; Robert O. Heuckeroth; Eugene Johnson; Jeffrey Milbrandt
Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons.
Neuron 2002;35(2):267-82.
2002: Rakesh Nagarajan; Nam Le; Heather Mahoney; Toshiyuki Araki; Jeffrey Milbrandt
Deciphering peripheral nerve myelination by using Schwann cell expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8998-9003.
2002: Wojtek P Rakowicz; Christopher S Staples; Jeffrey Milbrandt; Janice E Brunstrom; Eugene M Johnson
Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):3953-62.
2002: Gary D Luker; Kathryn E Luker; Vijay Sharma; Christina M Pica; Julie L Dahlheimer; Joseph A Ocheskey; Timothy J Fahrner; Jeffrey Milbrandt; David Piwnica-Worms
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Molecular imaging 2002;1(2):65-73.
2002: Sarki A Abdulkadir; Jeffrey A Magee; Thomas J Peters; Zahid Kaleem; Cathy K Naughton; Peter A Humphrey; Jeffrey Milbrandt
Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia.
Molecular and cellular biology 2002;22(5):1495-503.
2002: Brian A Tsui-Pierchala; Jeffrey Milbrandt; Eugene M Johnson
NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.
Neuron 2002;33(2):261-73.
2001: H Enomoto; P A Crawford; A Gorodinsky; Robert O. Heuckeroth; Eugene M Johnson; Jeffrey Milbrandt
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
Development (Cambridge, England) 2001;128(20):3963-74.
2001: Sarki A Abdulkadir; J M Carbone; Cathy K Naughton; Peter A Humphrey; William J Catalona; Jeffrey Milbrandt
Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma.
Human pathology 2001;32(9):935-9.
2001: Jeffrey A Magee; T Araki; S Patil; T Ehrig; Lawrence True; Peter A Humphrey; W J Catalona; M A Watson; Jeffrey Milbrandt
Expression profiling reveals hepsin overexpression in prostate cancer.
Cancer research 2001;61(15):5692-6.
2001: Rakesh Nagarajan; John Svaren; Nam Le; Toshiyuki Araki; M Watson; Jeffrey Milbrandt
EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.
Neuron 2001;30(2):355-68.
2001: R Dzialo-Hatton; Jeffrey Milbrandt; RD Hockett; Casey T Weaver
Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4534-42.
2001: Mario Encinas; M G Tansey; Brian A Tsui-Pierchala; Joan X Comella; Jeffrey Milbrandt; Eugene M Johnson
c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1464-72.
2001: T Ehrig; Sarki A Abdulkadir; S M Dintzis; Jeffrey Milbrandt; Mark A Watson
Quantitative amplification of genomic DNA from histological tissue sections after staining with nuclear dyes and laser capture microdissection.
The Journal of molecular diagnostics : JMD 2001;3(1):22-5.
2001: Sarki A Abdulkadir; Z Qu; E Garabedian; Sheng-Kwei Song; T J Peters; John Svaren; J M Carbone; Cathy K Naughton; William J Catalona; Joseph J H Ackerman; J I Gordon; Peter A Humphrey; Jeffrey Milbrandt
Impaired prostate tumorigenesis in Egr1-deficient mice.
Nature medicine 2001;7(1):101-7.
2000: John Svaren; T Ehrig; Sarki A Abdulkadir; M U Ehrengruber; Mark A Watson; Jeffrey Milbrandt
EGR1 target genes in prostate carcinoma cells identified by microarray analysis.
The Journal of biological chemistry 2000;275(49):38524-31.
2000: Hideki Enomoto; Robert O. Heuckeroth; Judith P Golden; Eugene M Johnson; Jeffrey Milbrandt
Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.
Development (Cambridge, England) 2000;127(22):4877-89.
2000: Sarki A Abdulkadir; G F Carvalhal; Zahid Kaleem; W Kisiel; Peter A Humphrey; William J Catalona; Jeffrey Milbrandt
Tissue factor expression and angiogenesis in human prostate carcinoma.
Human pathology 2000;31(4):443-7.
2000: BR Sevetson; John Svaren; Jeffrey Milbrandt
A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.
The Journal of biological chemistry 2000;275(13):9749-57.
2000: Malú G Tansey; Robert H Baloh; Jeffrey Milbrandt; Eugene M Johnson
GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival.
Neuron 2000;25(3):611-23.
2000: Robert H Baloh; Malú G Tansey; Eugene M Johnson; Jeffrey Milbrandt
Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists.
The Journal of biological chemistry 2000;275(5):3412-20.
2000: R H Baloh; H Enomoto; Eugene M Johnson; Jeffrey Milbrandt
The GDNF family ligands and receptors - implications for neural development.
Current opinion in neurobiology 2000;10(1):103-10.
1999: Melanie L Leitner; Derek C Molliver; Patricia A Osborne; R Vejsada; Judith P Golden; PA Lampe; Ann C Kato; Jeffrey Milbrandt; Eugene M Johnson
Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9322-31.
1999: Judith P Golden; JA Demaro; Patricia A Osborne; Jeffrey Milbrandt; Eugene M Johnson
Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse.
Experimental neurology 1999;158(2):504-28.
1999: LE Warner; J Svaren; Jeffrey Milbrandt; James R Lupski
Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.
Human molecular genetics 1999;8(7):1245-51.
1999: Robert O. Heuckeroth; Hideki Enomoto; John R Grider; Judith P Golden; J A Hanke; A Jackman; Derek C Molliver; M E Bardgett; William D Snider; Eugene M Johnson; Jeffrey Milbrandt
Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons.
Neuron 1999;22(2):253-63.
1998: Robert H Baloh; Malú G Tansey; PA Lampe; Timothy J Fahrner; Hideki Enomoto; KS Simburger; Melanie L Leitner; Toshiyuki Araki; Eugene M Johnson; Jeffrey Milbrandt
Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
Neuron 1998;21(6):1291-302.
1998: John Svaren; BR Sevetson; T Golda; J J Stanton; A H Swirnoff; Jeffrey Milbrandt
Novel mutants of NAB corepressors enhance activation by Egr transactivators.
The EMBO journal 1998;17(20):6010-9.
1998: W G Tourtellotte; Jeffrey Milbrandt
Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.
Nature genetics 1998;20(1):87-91.
1998: Z Qu; L A Wolfraim; John Svaren; M U Ehrengruber; N Davidson; Jeffrey Milbrandt
The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.
The Journal of cell biology 1998;142(4):1075-82.
1998: Judith P Golden; Robert H Baloh; PT Kotzbauer; PA Lampe; Patricia A Osborne; Jeffrey Milbrandt; Eugene M Johnson
Expression of neurturin, GDNF, and their receptors in the adult mouse CNS.
The Journal of comparative neurology 1998;398(1):139-50.
1998: Hideki Enomoto; Toshiyuki Araki; A Jackman; Robert O. Heuckeroth; William D Snider; Eugene M Johnson; Jeffrey Milbrandt
GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.
Neuron 1998;21(2):317-24.
1998: Robert O. Heuckeroth; PA Lampe; Eugene M Johnson; Jeffrey Milbrandt
Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro.
Developmental biology 1998;200(1):116-29.
1998: B A Horger; Merry Nishimura; Mark P Armanini; LC Wang; Kris T Poulsen; Carl Rosenblad; Deniz Kirik; Barbara Moffat; Laura Simmons; E Johnson; Jeffrey Milbrandt; Arnon Rosenthal; Anders Björklund; Richard Vandlen; Mary Hynes; Heidi S Phillips
Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(13):4929-37.
1998: Robert H Baloh; A Gorodinsky; Judith P Golden; Malú G Tansey; C L Keck; NC Popescu; Eugene M Johnson; Jeffrey Milbrandt
GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5801-6.
1998: PA Crawford; Christoph Dorn; Yoel Sadovsky; Jeffrey Milbrandt
Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1.
Molecular and cellular biology 1998;18(5):2949-56.
1998: Jeffrey Milbrandt; Frederic J de Sauvage; Timothy J Fahrner; Robert H Baloh; Melanie L Leitner; Malú G Tansey; PA Lampe; Robert O. Heuckeroth; PT Kotzbauer; KS Simburger; Judith P Golden; Jamie Andrew Davies; R Vejsada; Ann C Kato; Mary Hynes; D Sherman; Merry Nishimura; LC Wang; Richard Vandlen; Barbara Moffat; RD Klein; Kris T Poulsen; C Gray; A Garces; Eugene M Johnson
Persephin, a novel neurotrophic factor related to GDNF and neurturin.
Neuron 1998;20(2):245-53.
1998: A H Swirnoff; E D Apel; John Svaren; BR Sevetson; Drazen Zimonjic; N C Popescu; Jeffrey Milbrandt
Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.
Molecular and cellular biology 1998;18(1):512-24.
1997: T Araki; Drazen Zimonjic; N C Popescu; Jeffrey Milbrandt
Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule.
The Journal of biological chemistry 1997;272(34):21373-80.
1997: Robert O. Heuckeroth; PT Kotzbauer; N G Copeland; D J Gilbert; N A Jenkins; Drazen Zimonjic; NC Popescu; Eugene M Johnson; Jeffrey Milbrandt
Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3.
Genomics 1997;44(1):137-40.
1997: PA Crawford; Yoel Sadovsky; Jeffrey Milbrandt
Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage.
Molecular and cellular biology 1997;17(7):3997-4006.
1997: DJ Creedon; Malú G Tansey; Robert H Baloh; Patricia A Osborne; PA Lampe; Timothy J Fahrner; Robert O. Heuckeroth; Jeffrey Milbrandt; Eugene M Johnson
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):7018-23.
1997: Robert H Baloh; Malú G Tansey; Judith P Golden; DJ Creedon; Robert O. Heuckeroth; C L Keck; Drazen Zimonjic; NC Popescu; Eugene M Johnson; Jeffrey Milbrandt
TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
Neuron 1997;18(5):793-802.
1997: John Svaren; E D Apel; KS Simburger; N A Jenkins; D J Gilbert; N A Copeland; Jeffrey Milbrandt
The Nab2 and Stat6 genes share a common transcription termination region.
Genomics 1997;41(1):33-9.
1997: K G Woodson; PA Crawford; Yoel Sadovsky; Jeffrey Milbrandt
Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development.
Molecular endocrinology (Baltimore, Md.) 1997;11(2):117-26.
1997: A Gorodinsky; Drazen Zimonjic; NC Popescu; Jeffrey Milbrandt
Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization.
Cytogenetics and cell genetics 1997;78(3-4):289-90.
1996: P T Kotzbauer; PA Lampe; Robert O. Heuckeroth; Judith P Golden; DJ Creedon; Eugene M Johnson; Jeffrey Milbrandt
Neurturin, a relative of glial-cell-line-derived neurotrophic factor.
Nature 1996;384(6608):467-70.
1996: S L Lee; Yoel Sadovsky; A H Swirnoff; J A Polish; P Goda; G Gavrilina; Jeffrey Milbrandt
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Science (New York, N.Y.) 1996;273(5279):1219-21.
1996: Toshiyuki Araki; Jeffrey Milbrandt
Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.
Neuron 1996;17(2):353-61.
1996: S L Lee; Y Wang; Jeffrey Milbrandt
Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1).
Molecular and cellular biology 1996;16(8):4566-72.
1996: John Svaren; B R Sevetson; E D Apel; Drazen Zimonjic; N C Popescu; Jeffrey Milbrandt
NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.
Molecular and cellular biology 1996;16(7):3545-53.
1995: Yoel Sadovsky; PA Crawford; K G Woodson; J A Polish; M A Clements; L M Tourtellotte; K Simburger; Jeffrey Milbrandt
Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10939-43.
1995: PA Crawford; Yoel Sadovsky; K Woodson; S L Lee; Jeffrey Milbrandt
Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice.
Molecular and cellular biology 1995;15(8):4331-16.
1995: S L Lee; Robin Wesselschmidt; G P Linette; O Kanagawa; J H Russell; Jeffrey Milbrandt
Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).
Science (New York, N.Y.) 1995;269(5223):532-5.
1995: M W Russo; B R Sevetson; Jeffrey Milbrandt
Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6873-7.
1995: Steven L Carroll; J B Schweitzer; David M Holtzman; M L Miller; G M Sclar; Jeffrey Milbrandt
Elements in the 5' flanking sequences of the mouse low-affinity NGF receptor gene direct appropriate CNS, but not PNS, expression in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3342-56.
1995: S L Lee; L C Tourtellotte; Robin Wesselschmidt; Jeffrey Milbrandt
Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A.
The Journal of biological chemistry 1995;270(17):9971-7.
1995: A H Swirnoff; Jeffrey Milbrandt
DNA-binding specificity of NGFI-A and related zinc finger transcription factors.
Molecular and cellular biology 1995;15(4):2275-87.
1994: P T Kotzbauer; PA Lampe; Steven Estus; Jeffrey Milbrandt; Eugene M Johnson
Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor.
Neuron 1994;12(4):763-73.
1994: C Matheny; Mark Day; Jeffrey Milbrandt
The nuclear localization signal of NGFI-A is located within the zinc finger DNA binding domain.
The Journal of biological chemistry 1994;269(11):8176-81.
1993: M W Russo; C Matheny; Jeffrey Milbrandt
Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.
Molecular and cellular biology 1993;13(11):6858-65.
1993: Thomas E Wilson; K A Padgett; M Johnston; Jeffrey Milbrandt
A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9186-90.
1993: Thomas E Wilson; Timothy J Fahrner; Jeffrey Milbrandt
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
Molecular and cellular biology 1993;13(9):5794-804.
1993: Akio Wanaka; Steven L Carroll; Jeffrey Milbrandt
Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat.
Brain research. Developmental brain research 1993;72(1):133-44.
1992: Steven L Carroll; Inmaculada Silos-Santiago; S E Frese; K G Ruit; Jeffrey Milbrandt; William D Snider
Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero.
Neuron 1992;9(4):779-88.
1992: R E Paulsen; C A Weaver; Timothy J Fahrner; Jeffrey Milbrandt
Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.
The Journal of biological chemistry 1992;267(23):16491-6.
1992: Seth Crosby; Rosalie A Veile; H Donis-Keller; Jay M Baraban; R V Bhat; K S Simburger; Jeffrey Milbrandt
Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6663.
1992: Seth Crosby; Rosalie A Veile; H Donis-Keller; Jay M Baraban; R V Bhat; K S Simburger; Jeffrey Milbrandt
Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4739-43.
1992: Thomas E Wilson; R E Paulsen; K A Padgett; Jeffrey Milbrandt
Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.
Science (New York, N.Y.) 1992;256(5053):107-10.
1992: C Matheny; PS DiStefano; Jeffrey Milbrandt
Differential activation of NGF receptor and early response genes in neural crest-derived cells.
Brain research. Molecular brain research 1992;13(1-2):75-81.
1992: Thomas E Wilson; Mark Day; T Pexton; K A Padgett; M Johnston; Jeffrey Milbrandt
In vivo mutational analysis of the NGFI-A zinc fingers.
The Journal of biological chemistry 1992;267(6):3718-24.
1991: Seth Crosby; J J Puetz; K S Simburger; Timothy J Fahrner; Jeffrey Milbrandt
The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.
Molecular and cellular biology 1991;11(8):3835-41.
1991: Thomas E Wilson; Timothy J Fahrner; M Johnston; Jeffrey Milbrandt
Identification of the DNA binding site for NGFI-B by genetic selection in yeast.
Science (New York, N.Y.) 1991;252(5010):1296-300.
1990: Timothy J Fahrner; Steven L Carroll; Jeffrey Milbrandt
The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally.
Molecular and cellular biology 1990;10(12):6454-9.
1990: Mark Day; Timothy J Fahrner; S Aykent; Jeffrey Milbrandt
The zinc finger protein NGFI-A exists in both nuclear and cytoplasmic forms in nerve growth factor-stimulated PC12 cells.
The Journal of biological chemistry 1990;265(25):15253-60.
1990: M A Watson; Jeffrey Milbrandt
Expression of the nerve growth factor-regulated NGFI-A and NGFI-B genes in the developing rat.
Development (Cambridge, England) 1990;110(1):173-83.
1989: M A Watson; Jeffrey Milbrandt
The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction.
Molecular and cellular biology 1989;9(10):4213-9.
1989: Paul Changelian; P Feng; T C King; Jeffrey Milbrandt
Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):377-81.
1988: Jeffrey Milbrandt
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.
Neuron 1988;1(3):183-8.
1987: Jeffrey Milbrandt
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.
Science (New York, N.Y.) 1987;238(4828):797-9.