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Albert Mildvan

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Xiaoyi V Hu; Xiaochun Chen; Kee-Chung Han; Albert S Mildvan; Jun O Liu
Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.
Sandra B. Gabelli; Hugo F Azurmendi; Mario Antonio Bianchet; Mario Amzel; Albert S Mildvan
X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.
Zuyong Xia; Hugo F Azurmendi; Albert S Mildvan
Transient state kinetic studies of the MutT-catalyzed nucleoside triphosphate pyrophosphohydrolase reaction.

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2007: Xiaoyi V Hu; Xiaochun Chen; Kee-Chung Han; Albert S Mildvan; Jun O Liu
Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.
Biochemistry 2007;46(44):12833-43.
2006: Sandra B. Gabelli; Hugo F Azurmendi; Mario Antonio Bianchet; Mario Amzel; Albert S Mildvan
X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.
Biochemistry 2006;45(38):11290-303.
2005: Zuyong Xia; Hugo F Azurmendi; Albert S Mildvan
Transient state kinetic studies of the MutT-catalyzed nucleoside triphosphate pyrophosphohydrolase reaction.
Biochemistry 2005;44(46):15334-44.
2005: Zuyong Xia; Hugo F Azurmendi; Luke L Lairson; Stephen G Withers; Sandra B. Gabelli; Mario Antonio Bianchet; Mario Amzel; Albert S Mildvan
Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction.
Biochemistry 2005;44(25):8989-97.
2005: Hugo F Azurmendi; Scott G Miller; Christian P Whitman; Albert S Mildvan
Half-of-the-sites binding of reactive intermediates and their analogues to 4-oxalocrotonate tautomerase and induced structural asymmetry of the enzyme.
Biochemistry 2005;44(21):7725-37.
2005: Albert S Mildvan; Zuyong Xia; Hugo F Azurmendi; Vibhor Saraswat; Patricia M Legler; Michael A Massiah; Sandra B. Gabelli; Mario Antonio Bianchet; Lin-Woo Kang; Mario Amzel
Structures and mechanisms of Nudix hydrolases.
Archives of biochemistry and biophysics 2005;433(1):129-43.
2004: Albert S Mildvan
Inverse thinking about double mutants of enzymes.
Biochemistry 2004;43(46):14517-20.
2004: Sandra B. Gabelli; Mario Antonio Bianchet; Hugo F Azurmendi; Zuyong Xia; Vibhor Sarawat; Albert S Mildvan; Mario Amzel
Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus.
Structure (London, England : 1993) 2004;12(6):927-35.
2004: Hugo F Azurmendi; Susan C Wang; Michael A Massiah; Gerrit J Poelarends; Christian P Whitman; Albert S Mildvan
The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis.
Biochemistry 2004;43(14):4082-91.
2004: Vibhor Saraswat; Hugo F Azurmendi; Albert S Mildvan
Mutational, NMR, and NH exchange studies of the tight and selective binding of 8-oxo-dGMP by the MutT pyrophosphohydrolase.
Biochemistry 2004;43(12):3404-14.
2003: Michael A Massiah; Vibhor Saraswat; Hugo F Azurmendi; Albert S Mildvan
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
Biochemistry 2003;42(34):10140-54.
2002: Vibhor Saraswat; Michael A Massiah; Gregory Lopez; Mario Amzel; Albert S Mildvan
Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase.
Biochemistry 2002;41(52):15566-77.
2002: Patricia M Legler; Michael A Massiah; Albert S Mildvan
Mutational, kinetic, and NMR studies of the mechanism of E. coli GDP-mannose mannosyl hydrolase, an unusual Nudix enzyme.
Biochemistry 2002;41(35):10834-48.
2002: Patricia M Legler; H Caroline Lee; Jack Peisach; Albert S Mildvan
Kinetic and magnetic resonance studies of the role of metal ions in the mechanism of Escherichia coli GDP-mannose mannosyl hydrolase, an unusual nudix enzyme.
Biochemistry 2002;41(14):4655-68.
2002: Eric C Bolton; Albert S Mildvan; Jef Boeke
Inhibition of reverse transcription in vivo by elevated manganese ion concentration.
Molecular cell 2002;9(4):879-89.
2001: G T Marks; Thomas K Harris; Michael A Massiah; Albert S Mildvan; David H T Harrison
Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.
Biochemistry 2001;40(23):6805-18.
2001: Michael A Massiah; Carol Viragh; P M Reddy; Ildiko M Kovach; J Johnson; Terrone L Rosenberry; Albert S Mildvan
Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies.
Biochemistry 2001;40(19):5682-90.
2001: Robert M Czerwinski; Thomas K Harris; Michael A Massiah; Albert S Mildvan; Christian P Whitman
The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.
Biochemistry 2001;40(7):1984-95.
2000: Carol Viragh; Thomas K Harris; P M Reddy; Michael A Massiah; Albert S Mildvan; Ildiko M Kovach
NMR evidence for a short, strong hydrogen bond at the active site of a cholinesterase.
Biochemistry 2000;39(51):16200-5.
2000: Patricia M Legler; Michael A Massiah; Maurice J Bessman; Albert S Mildvan
GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases.
Biochemistry 2000;39(29):8603-8.
2000: G B Conyers; Gang Wu; Maurice J Bessman; Albert S Mildvan
Metal requirements of a diadenosine pyrophosphatase from Bartonella bacilliformis: magnetic resonance and kinetic studies of the role of Mn2+.
Biochemistry 2000;39(9):2347-54.
2000: Thomas K Harris; Gang Wu; Michael A Massiah; Albert S Mildvan
Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase.
Biochemistry 2000;39(7):1655-74.
1999: Robert M Czerwinski; Thomas K Harris; William H Johnson; Patricia M Legler; James T Stivers; Albert S Mildvan; Christian P Whitman
Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis.
Biochemistry 1999;38(38):12358-66.
1999: Thomas K Harris; Robert M Czerwinski; William H Johnson; Patricia M Legler; C Abeygunawardana; Michael A Massiah; James T Stivers; Christian P Whitman; Albert S Mildvan
Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.
Biochemistry 1999;38(38):12343-57.
1999: Michael A Massiah; Young H Ko; Peter L Pedersen; Albert S Mildvan
Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation.
Biochemistry 1999;38(23):7453-61.
1999: Thomas K Harris; Albert S Mildvan
High-precision measurement of hydrogen bond lengths in proteins by nuclear magnetic resonance methods.
Proteins 1999;35(3):275-82.
1999: Albert S Mildvan; Thomas K Harris; C Abeygunawardana
Nuclear magnetic resonance methods for the detection and study of low-barrier hydrogen bonds on enzymes.
Methods in enzymology 1999;308():219-45.
1999: Albert S Mildvan; David Weber; C Abeygunawardana
Solution structure and mechanism of the MutT pyrophosphohydrolase.
Advances in enzymology and related areas of molecular biology 1999;73():183-207.
1998: Thomas K Harris; Robert N Cole; Frank I Comer; Albert S Mildvan
Proton transfer in the mechanism of triosephosphate isomerase.
Biochemistry 1998;37(47):16828-38.
1998: Michael A Massiah; C Abeygunawardana; A G Gittis; Albert S Mildvan
Solution structure of Delta 5-3-ketosteroid isomerase complexed with the steroid 19-nortestosterone hemisuccinate.
Biochemistry 1998;37(42):14701-12.
1997: Thomas K Harris; C Abeygunawardana; Albert S Mildvan
NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase.
Biochemistry 1997;36(48):14661-75.
1997: Q Zhao; C Abeygunawardana; A G Gittis; Albert S Mildvan
Hydrogen bonding at the active site of delta 5-3-ketosteroid isomerase.
Biochemistry 1997;36(48):14616-26.
1997: Albert S Mildvan
Mechanisms of signaling and related enzymes.
Proteins 1997;29(4):401-16.
1997: James T Stivers; Thomas K Harris; Albert S Mildvan
Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation.
Biochemistry 1997;36(17):5212-22.
1997: Q Zhao; C Abeygunawardana; Albert S Mildvan
NMR studies of the secondary structure in solution and the steroid binding site of delta5-3-ketosteroid isomerase in complexes with diamagnetic and paramagnetic steroids.
Biochemistry 1997;36(12):3458-72.
1997: J Lin; C Abeygunawardana; DN Frick; Maurice J Bessman; Albert S Mildvan
Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action.
Biochemistry 1997;36(6):1199-211.
1996: James T Stivers; C Abeygunawardana; Albert S Mildvan
15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: backbone dynamics and entropy changes of an enzyme upon inhibitor binding.
Biochemistry 1996;35(50):16036-47.
1996: Suzanne F O'handley; D N Frick; L C Bullions; Albert S Mildvan; Maurice J Bessman
Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme.
The Journal of biological chemistry 1996;271(40):24649-54.
1996: Q Zhao; C Abeygunawardana; Paul Talalay; Albert S Mildvan
NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8220-4.
1996: J Lin; C Abeygunawardana; D N Frick; Maurice J Bessman; Albert S Mildvan
The role of Glu 57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR.
Biochemistry 1996;35(21):6715-26.
1996: James T Stivers; C Abeygunawardana; Christian P Whitman; Albert S Mildvan
4-Oxalocrotonate tautomerase, a 41-kDa homohexamer: backbone and side-chain resonance assignments, solution secondary structure, and location of active site residues by heteronuclear NMR spectroscopy.
Protein science : a publication of the Protein Society 1996;5(4):729-41.
1996: Q Zhao; C Abeygunawardana; Albert S Mildvan
13C NMR relaxation studies of backbone and side chain motion of the catalytic tyrosine residue in free and steroid-bound delta 5-3-ketosteroid isomerase.
Biochemistry 1996;35(5):1525-32.
1996: James T Stivers; C Abeygunawardana; Albert S Mildvan; G Hajipour; Christian P Whitman
4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues.
Biochemistry 1996;35(3):814-23.
1996: James T Stivers; C Abeygunawardana; Albert S Mildvan; G Hajipour; Christian P Whitman; L H Chen
Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies.
Biochemistry 1996;35(3):803-13.
1995: C Abeygunawardana; David Weber; Apostolos G Gittis; D N Frick; J Lin; A F Miller; Maurice J Bessman; Albert S Mildvan
Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase.
Biochemistry 1995;34(46):14997-5005.
1995: Q Zhao; Y K Li; Albert S Mildvan; Paul Talalay
Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding.
Biochemistry 1995;34(19):6562-72.
1995: W J Chuang; C Abeygunawardana; Apostolos G Gittis; Peter L Pedersen; Albert S Mildvan
Solution structure and function in trifluoroethanol of PP-50, an ATP-binding peptide from F1ATPase.
Archives of biochemistry and biophysics 1995;319(1):110-22.
1995: D N Frick; David Weber; C Abeygunawardana; Apostolos G Gittis; Maurice J Bessman; Albert S Mildvan
NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme.
Biochemistry 1995;34(16):5577-86.
1995: Q Zhao; Albert S Mildvan; Paul Talalay
Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase.
Biochemistry 1995;34(2):426-34.
1994: James T Stivers; Stewart Shuman; Albert S Mildvan
Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step.
Biochemistry 1994;33(51):15449-58.
1994: David Weber; A M Libson; Apostolos G Gittis; MS Lebowitz; Albert S Mildvan
NMR docking of a substrate into the X-ray structure of the Asp-21-->Glu mutant of staphylococcal nuclease.
Biochemistry 1994;33(26):8017-28.
1994: D N Frick; David Weber; J R Gillespie; Maurice J Bessman; Albert S Mildvan
Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes.
The Journal of biological chemistry 1994;269(3):1794-803.
1994: James T Stivers; Stewart Shuman; Albert S Mildvan
Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions.
Biochemistry 1994;33(1):327-39.
1994: W J Chuang; Apostolos G Gittis; Albert S Mildvan
Magnetic resonance studies of the binding of oligonucleotide substrates to mutants of staphylococcal nuclease.
Proteins 1994;18(1):68-80.
1993: David Weber; C Abeygunawardana; Maurice J Bessman; Albert S Mildvan
Secondary structure of the MutT enzyme as determined by NMR.
Biochemistry 1993;32(48):13081-8.
1993: C Abeygunawardana; David Weber; D N Frick; Maurice J Bessman; Albert S Mildvan
Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR.
Biochemistry 1993;32(48):13071-80.
1993: W J Chuang; David Weber; Apostolos G Gittis; Albert S Mildvan
Mutational tests of the NMR-docked structure of the staphylococcal nuclease-metal-3',5'-pdTp complex.
Proteins 1993;17(1):36-48.
1993: David Weber; E H Serpersu; Apostolos G Gittis; Eaton E Lattman; Albert S Mildvan
NMR docking of the competitive inhibitor thymidine 3',5'-diphosphate into the X-ray structure of staphylococcal nuclease.
Proteins 1993;17(1):20-35.
1993: Y K Li; A Kuliopulos; Albert S Mildvan; Paul Talalay
Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase.
Biochemistry 1993;32(7):1816-24.
1993: G P Mullen; J B Vaughn; Albert S Mildvan
Sequential proton NMR resonance assignments, circular dichroism, and structural properties of a 50-residue substrate-binding peptide from DNA polymerase I.
Archives of biochemistry and biophysics 1993;301(1):174-83.
1992: W J Chuang; C Abeygunawardana; Peter L Pedersen; Albert S Mildvan
Two-dimensional NMR, circular dichroism, and fluorescence studies of PP-50, a synthetic ATP-binding peptide from the beta-subunit of mitochondrial ATP synthase.
Biochemistry 1992;31(34):7915-21.
1992: David Weber; S K Bhatnagar; L C Bullions; Maurice J Bessman; Albert S Mildvan
NMR and isotopic exchange studies of the site of bond cleavage in the MutT reaction.
The Journal of biological chemistry 1992;267(24):16939-42.
1992: David Weber; Apostolos G Gittis; G P Mullen; C Abeygunawardana; Eaton E Lattman; Albert S Mildvan
NMR docking of a substrate into the X-ray structure of staphylococcal nuclease.
Proteins 1992;13(4):275-87.
1992: Albert S Mildvan; David Weber; A Kuliopulos
Quantitative interpretations of double mutations of enzymes.
Archives of biochemistry and biophysics 1992;294(2):327-40.
1991: H Han; J M Rifkind; Albert S Mildvan
Role of divalent cations in the 3',5'-exonuclease reaction of DNA polymerase I.
Biochemistry 1991;30(46):11104-8.
1991: L A Xue; Paul Talalay; Albert S Mildvan
Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects.
Biochemistry 1991;30(45):10858-65.
1991: David Weber; G P Mullen; Albert S Mildvan
Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR.
Biochemistry 1991;30(30):7425-37.
1991: David Weber; Alan K Meeker; Albert S Mildvan
Interactions of the acid and base catalysts on staphylococcal nuclease as studied in a double mutant.
Biochemistry 1991;30(25):6103-14.
1991: L A Xue; A Kuliopulos; Albert S Mildvan; Paul Talalay
Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates.
Biochemistry 1991;30(20):4991-7.
1991: A Kuliopulos; G P Mullen; L Xue; Albert S Mildvan
Stereochemistry of the concerted enolization catalyzed by delta 5-3-ketosteroid isomerase.
Biochemistry 1991;30(13):3169-78.
1990: A Kuliopulos; Paul Talalay; Albert S Mildvan
Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction.
Biochemistry 1990;29(44):10271-80.
1990: David Weber; E H Serpersu; David Shortle; Albert S Mildvan
Diverse interactions between the individual mutations in a double mutant at the active site of staphylococcal nuclease.
Biochemistry 1990;29(37):8632-42.
1990: G P Mullen; E H Serpersu; L J Ferrin; L A Loeb; Albert S Mildvan
Metal binding to DNA polymerase I, its large fragment, and two 3',5'-exonuclease mutants of the large fragment.
The Journal of biological chemistry 1990;265(24):14327-34.
1990: L A Xue; Paul Talalay; Albert S Mildvan
Studies of the mechanism of the delta 5-3-ketosteroid isomerase reaction by substrate, solvent, and combined kinetic deuterium isotope effects on wild-type and mutant enzymes.
Biochemistry 1990;29(32):7491-500.
1990: G P Mullen; J B Vaughn; P Shenbagamurthi; Albert S Mildvan
NMR studies of the active site of DNA polymerase I and of a 50-residue peptide fragment of the enzyme.
Biochemical pharmacology 1990;40(1):69-81.
1989: G P Mullen; P Shenbagamurthi; Albert S Mildvan
Substrate and DNA binding to a 50-residue peptide fragment of DNA polymerase I. Comparison with the enzyme.
The Journal of biological chemistry 1989;264(33):19637-47.
1989: Albert S Mildvan
Nuclear relaxation and Overhauser effect studies of enzyme-substrate interactions.
Archivos de biología y medicina experimentales 1989;22(2):147-51.
1989: Albert S Mildvan
NMR studies of the interactions of substrates with enzymes and their peptide fragments.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(6):1705-14.
1989: E H Serpersu; D W Hibler; John Alan Gerlt; Albert S Mildvan
Kinetic and magnetic resonance studies of the glutamate-43 to serine mutant of staphylococcal nuclease.
Biochemistry 1989;28(4):1539-48.
1989: A Kuliopulos; Albert S Mildvan; David Shortle; Paul Talalay
Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase.
Biochemistry 1989;28(1):149-59.
1988: E H Serpersu; J McCracken; Jack Peisach; Albert S Mildvan
Electron spin echo modulation and nuclear relaxation studies of staphylococcal nuclease and its metal-coordinating mutants.
Biochemistry 1988;27(21):8034-44.
1988: D C Fry; D M Byler; H Susi; E M Brown; S A Kuby; Albert S Mildvan
Solution structure of the 45-residue MgATP-binding peptide of adenylate kinase as examined by 2-D NMR, FTIR, and CD spectroscopy.
Biochemistry 1988;27(10):3588-98.
1987: A Kuliopulos; E M Westbrook; Paul Talalay; Albert S Mildvan
Positioning of a spin-labeled substrate analogue into the structure of delta 5-3-ketosteroid isomerase by combined kinetic, magnetic resonance, and X-ray diffraction methods.
Biochemistry 1987;26(13):3927-37.
1987: D C Fry; S A Kuby; Albert S Mildvan
NMR studies of the AMP-binding site and mechanism of adenylate kinase.
Biochemistry 1987;26(6):1645-55.
1987: E H Serpersu; David Shortle; Albert S Mildvan
Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis.
Biochemistry 1987;26(5):1289-300.
1986: D C Fry; S A Kuby; Albert S Mildvan
ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):907-11.
1986: E H Serpersu; David Shortle; Albert S Mildvan
Kinetic and magnetic resonance studies of effects of genetic substitution of a Ca2+-liganding amino acid in staphylococcal nuclease.
Biochemistry 1986;25(1):68-77.
1985: D C Fry; S A Kuby; Albert S Mildvan
NMR studies of the MgATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme.
Biochemistry 1985;24(17):4680-94.