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Caroline Miles

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Davide Papale; Chiara Bruckmann; Ben Gazur; Caroline S Miles; Christopher G Mowat; Simon Daff
Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.
Miguel Pessanha; Emma L Rothery; Caroline S Miles; Graeme A Reid; Stephen K Chapman; Ricardo Louro; David L Turner; Carlos A Salgueiro; António V Xavier
Tuning of functional heme reduction potentials in Shewanella fumarate reductases.
Bor-Ran Li; J L Ross Anderson; Christopher G Mowat; Caroline S Miles; Graeme A Reid; Stephen K Chapman
Rhodobacter sphaeroides haem protein: a novel cytochrome with nitric oxide dioxygenase activity.

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All Publications

2012: Davide Papale; Chiara Bruckmann; Ben Gazur; Caroline S Miles; Christopher G Mowat; Simon Daff
Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.
The Biochemical journal 2012;443(2):505-14.
2009: Miguel Pessanha; Emma L Rothery; Caroline S Miles; Graeme A Reid; Stephen K Chapman; Ricardo Louro; David L Turner; Carlos A Salgueiro; António V Xavier
Tuning of functional heme reduction potentials in Shewanella fumarate reductases.
Biochimica et biophysica acta 2009;1787(2):113-20.
2008: Bor-Ran Li; J L Ross Anderson; Christopher G Mowat; Caroline S Miles; Graeme A Reid; Stephen K Chapman
Rhodobacter sphaeroides haem protein: a novel cytochrome with nitric oxide dioxygenase activity.
Biochemical Society transactions 2008;36(Pt 5):992-5.
2006: Katherine L Pankhurst; Christopher G Mowat; Emma L Rothery; Janette M Hudson; Anne K Jones; Caroline S Miles; Malcolm D Walkinshaw; Fraser A Armstrong; Graeme A Reid; Stephen K Chapman
A proton delivery pathway in the soluble fumarate reductase from Shewanella frigidimarina.
The Journal of biological chemistry 2006;281(29):20589-97.
2006: Helen R Gibson; Christopher G Mowat; Caroline S Miles; Bor-Ran Li; David Leys; Graeme A Reid; Stephen K Chapman
Structural and functional studies on DHC, the diheme cytochrome c from Rhodobacter sphaeroides, and its interaction with SHP, the sphaeroides heme protein.
Biochemistry 2006;45(20):6363-71.
2006: Jonathan P Clark; Caroline S Miles; Christopher G Mowat; Malcolm D Walkinshaw; Graeme A Reid; Simon Daff; Stephen K Chapman
The role of Thr268 and Phe393 in cytochrome P450 BM3.
Journal of inorganic biochemistry 2006;100(5-6):1075-90.
2004: Miguel Pessanha; Emma L Rothery; Ricardo Louro; David L Turner; Caroline S Miles; Graeme A Reid; Stephen K Chapman; António V Xavier; Carlos A Salgueiro
Redox behaviour of the haem domain of flavocytochrome c3 from Shewanella frigidimarina probed by NMR.
FEBS letters 2004;578(1-2):185-90.
2004: Christopher G Mowat; Emma L Rothery; Caroline S Miles; Lisa McIver; Mary K Doherty; Katy Drewette; Paul Taylor; Malcolm D Walkinshaw; Stephen K Chapman; Graeme A Reid
Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation.
Nature structural & molecular biology 2004;11(10):1023-4.
2004: Emma L Rothery; Christopher G Mowat; Caroline S Miles; Sarah Mott; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Probing domain mobility in a flavocytochrome.
Biochemistry 2004;43(17):4983-9.
2003: Tobias W B Ost; Jonathan Clark; Christopher G Mowat; Caroline S Miles; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman; Simon Daff
Oxygen activation and electron transfer in flavocytochrome P450 BM3.
Journal of the American Chemical Society 2003;125(49):15010-20.
2003: Emma L Rothery; Christopher G Mowat; Caroline S Miles; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Histidine 61: an important heme ligand in the soluble fumarate reductase from Shewanella frigidimarina.
Biochemistry 2003;42(45):13160-9.
2002: Christopher G Mowat; Katherine L Pankhurst; Caroline S Miles; David Leys; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Engineering water to act as an active site acid catalyst in a soluble fumarate reductase.
Biochemistry 2002;41(40):11990-6.
2002: Katherine L Pankhurst; Christopher G Mowat; Caroline S Miles; David Leys; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Role of His505 in the soluble fumarate reductase from Shewanella frigidimarina.
Biochemistry 2002;41(27):8551-6.
2002: Andrew W Munro; David G Leys; Kirsty J McLean; Ker R Marshall; Tobias W B Ost; Simon Daff; Caroline S Miles; Stephen K Chapman; Dominikus Lysek; Christopher C Moser; Christopher C Page; P Leslie Dutton
P450 BM3: the very model of a modern flavocytochrome.
Trends in biochemical sciences 2002;27(5):250-7.
2001: Tobias W B Ost; Caroline S Miles; Andrew W Munro; J Murdoch; Graeme A Reid; Stephen K Chapman
Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.
Biochemistry 2001;40(45):13421-9.
2001: Christopher G Mowat; RK Moysey; Caroline S Miles; David Leys; Mary K Doherty; Paul Taylor; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Kinetic and crystallographic analysis of the key active site acid/base arginine in a soluble fumarate reductase.
Biochemistry 2001;40(41):12292-8.
2000: Caroline S Miles; Tobias W B Ost; Michael A Noble; Andrew W Munro; Stephen K Chapman
Protein engineering of cytochromes P-450.
Biochimica et biophysica acta 2000;1543(2):383-407.
2000: Tobias W B Ost; Caroline S Miles; J Murdoch; Y Cheung; Graeme A Reid; Stephen K Chapman; Andrew W Munro
Rational re-design of the substrate binding site of flavocytochrome P450 BM3.
FEBS letters 2000;486(2):173-7.
2000: Christopher G Mowat; Caroline S Miles; Andrew W Munro; Myles R Cheesman; Luca Quaroni; Graeme A Reid; Stephen K Chapman
Changing the heme ligation in flavocytochrome b2: substitution of histidine-66 by cysteine.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(5):584-92.
2000: Mary K Doherty; SL Pealing; Caroline S Miles; RK Moysey; Paul Taylor; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study.
Biochemistry 2000;39(35):10695-701.
2000: Graeme A Reid; Caroline S Miles; RK Moysey; Katherine L Pankhurst; Stephen K Chapman
Catalysis in fumarate reductase.
Biochimica et biophysica acta 2000;1459(2-3):310-5.
2000: Andrew W Munro; Michael A Noble; Tobias W B Ost; A J Green; Kirsty J McLean; L Robledo; Caroline S Miles; J Murdoch; Stephen K Chapman
Flavocytochrome P450 BM3 substrate selectivity and electron transfer in a model cytochrome P450.
Sub-cellular biochemistry 2000;35():297-315.
1999: Michael A Noble; Caroline S Miles; Stephen K Chapman; Dominikus Lysek; A C MacKay; Graeme A Reid; R P Hanzlik; Andrew W Munro
Roles of key active-site residues in flavocytochrome P450 BM3.
The Biochemical journal 1999;339 ( Pt 2)():371-9.
1999: Andrew W Munro; Michael A Noble; Caroline S Miles; Simon Daff; A J Green; Luca Quaroni; Stuart L Rivers; Tobias W B Ost; Graeme A Reid; Stephen K Chapman
Flavocytochrome P-450 BM3: a paradigm for the analysis of electron transfer and its control in the P-450s.
Biochemical Society transactions 1999;27(2):190-6.
1996: K H Lé; Caroline S Miles; Florence Lederer
Functional uncoupling between flavin and heme domains in flavocytochrome b2 by a monoclonal antibody.
Biochemical Society transactions 1996;24(1):16S.
1993: Caroline S Miles; F D Manson; Graeme A Reid; Stephen K Chapman
Substitution of a haem-iron axial ligand in flavocytochrome b2.
Biochimica et biophysica acta 1993;1202(1):82-6.
1992: Caroline S Miles; N Rouvière-Fourmy; Florence Lederer; F S Mathews; Graeme A Reid; M T Black; Stephen K Chapman
Tyr-143 facilitates interdomain electron transfer in flavocytochrome b2.
The Biochemical journal 1992;285 ( Pt 1)():187-92.