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Wilbur Milhous

Research Profile

Chemicals & Drugs

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Mihaela Perić; Renata Rupčić; Kirsten S Smith; Dinko Ziher; Arba Ager; Sulejman Alihodžić; Mirjana Bukvić Krajačić; William Y Ellis; Andrea Fajdetić; Antun Hutinec; Zrinka Ivezić-Schönfeld; Dubravko Jelić; Goran Landek; Milan Mesić; Wilbur K Milhous; Colin Ohrt; Jasna Padovan; Radan Spaventi
Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin.
Mirjana Bukvić Krajačić; William Ellis; Andrea Fajdetić; Dubravko Jelić; Nedjeljko Kujundžić; Goran Landek; Wilbur K Milhous; Jasna Padovan; Mihaela Perić; Wolfgang Schönfeld; Zrinka Ivezić Schönfeld; Kirsten S Smith; Radan Spaventi; Dinko Žiher; Arba Ager; Colin Ohrt
Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides.
Clare E Gutteridge; Marshall M Hoffman; Apurba K Bhattacharjee; Wilbur K Milhous; Lucia Gerena
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones.

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All Publications

2012: Mihaela Perić; Renata Rupčić; Kirsten S Smith; Dinko Ziher; Arba Ager; Sulejman Alihodžić; Mirjana Bukvić Krajačić; William Y Ellis; Andrea Fajdetić; Antun Hutinec; Zrinka Ivezić-Schönfeld; Dubravko Jelić; Goran Landek; Milan Mesić; Wilbur K Milhous; Colin Ohrt; Jasna Padovan; Radan Spaventi
Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin.
Journal of medicinal chemistry 2012;55(3):1389-401.
2011: Mirjana Bukvić Krajačić; William Ellis; Andrea Fajdetić; Dubravko Jelić; Nedjeljko Kujundžić; Goran Landek; Wilbur K Milhous; Jasna Padovan; Mihaela Perić; Wolfgang Schönfeld; Zrinka Ivezić Schönfeld; Kirsten S Smith; Radan Spaventi; Dinko Žiher; Arba Ager; Colin Ohrt
Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides.
Journal of medicinal chemistry 2011;54(10):3595-605.
2011: Clare E Gutteridge; Marshall M Hoffman; Apurba K Bhattacharjee; Wilbur K Milhous; Lucia Gerena
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones.
Bioorganic & medicinal chemistry letters 2011;21(2):786-9.
2011: Geoffrey S Dow; Montip Gettayacamin; Pranee Hansukjariya; Rawiwan Imerbsin; David Kenworthy; Srawuth Komcharoen; Dennis Kyle; Wilbur K Milhous; Anne Miller; jetsumon prachumsri; Jim Veazey; Simon Cozens; Colin Ohrt
Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
Malaria journal 2011;10():212.
2011: James W Kazura; Jonathan Ripp; Wilbur K Milhous
Back to the future: the American Society of Tropical Medicine and Hygiene, its journal and the continuing commitment to global health.
The American journal of tropical medicine and hygiene 2011;84(1):3-4.
2010: Yulia M Serebrennikova; Janus Patel; Wilbur K Milhous; Luis H García-Rubio
Quantitative analysis of morphological alterations in Plasmodium falciparum infected red blood cells through theoretical interpretation of spectral measurements.
Journal of theoretical biology 2010;265(4):493-500.
2010: Timothy J Whitman; Philip E Coyne; Alan J Magill; David L Blazes; Michael D Green; Wilbur K Milhous; Timothy H Burgess; Daniel Freilich; Sybil A Tasker; Ramzy G Azar; Timothy Endy; Christopher D Clagett; Gregory Deye; G Dennis Shanks; Gregory J Martin
An outbreak of Plasmodium falciparum malaria in U.S. Marines deployed to Liberia.
The American journal of tropical medicine and hygiene 2010;83(2):258-65.
2010: Wilbur K Milhous; Peter J Weina
Plant science. The botanical solution for malaria.
Science (New York, N.Y.) 2010;327(5963):279-80.
2009: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Akintunde Sowunmi; T Hudson; M O'Neil; Wilbur K Milhous; Dyann F Wirth; A M J Oduola
Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.
Antimicrobial agents and chemotherapy 2009;53(3):888-95.
2008: Igor Opsenica; Dejan Opsenica; Charlotte Anne Lanteri; Lalaine Anova; Wilbur K Milhous; Kirsten S Smith; Bogdan A Solaja
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.
Journal of medicinal chemistry 2008;51(19):6216-9.
2008: Bogdan A Solaja; Dejan Opsenica; Kirsten S Smith; Wilbur K Milhous; Natasa Terzić; Igor Opsenica; James C Burnett; Jon Nuss; Rick Gussio; Sina Bavari
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.
Journal of medicinal chemistry 2008;51(15):4388-91.
2008: Igor Opsenica; Dejan Opsenica; Kirsten S Smith; Wilbur K Milhous; Bogdan A Solaja
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.
Journal of medicinal chemistry 2008;51(7):2261-6.
2008: Damaris S Diaz; Michael P Kozar; Kirsten S Smith; Constance O Asher; Jason C Sousa; Guy A Schiehser; David P Jacobus; Wilbur K Milhous; Donald R Skillman; Todd W Shearer
Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):380-5.
2008: Ernest J Mui; Guy A Schiehser; Wilbur K Milhous; Honghue Hsu; Craig William Roberts; Michael J Kirisits; Stephen P Muench; David Rice; J P Dubey; Joseph W Fowble; Pradipsinh K Rathod; Sherry F Queener; Susan R Liu; David P Jacobus; Rima McLeod
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.
PLoS neglected tropical diseases 2008;2(3):e190.
2007: Jian Guan; Xihong Wang; Kirsten Smith; Arba Ager; Montip Gettayacamin; Dennis E Kyle; Wilbur K Milhous; Michael P Kozar; Alan J Magill; Ai J Lin
Malaria causal prophylactic activity of imidazolidinedione derivatives.
Journal of medicinal chemistry 2007;50(24):6226-31.
2007: Natasa Terzić; Dejan Opsenica; Dragana Milić; Bernard Tinant; Kirsten S Smith; Wilbur K Milhous; Bogdan A Solaja
Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1).
Journal of medicinal chemistry 2007;50(21):5118-27.
2007: Qigui Li; Michael P Kozar; Todd W Shearer; Lisa H Xie; Ai J Lin; Kirsten S Smith; Yuanzheng Si; Lalaine Anova; Jing Zhang; Wilbur K Milhous; Donald R Skillman
Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats.
Antimicrobial agents and chemotherapy 2007;51(8):2898-904.
2007: Lisa Xie; Qigui Li; J Johnson; Jing Zhang; Wilbur K Milhous; Dennis Kyle
Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria.
Parasitology 2007;134(Pt 9):1151-62.
2007: Qigui Li; Lucia Gerena; Lisa Xie; Jing Zhang; Dennis Kyle; Wilbur K Milhous
Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(5):297-307.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Akintunde Sowunmi; Olayinka M Bolaji; Babasola A Fateye; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria.
Parasitology research 2006;100(1):141-8.
2006: Grace O Gbotosho; O A T Ogundahunsi; Christian T Happi; Dennis E Kyle; Lucia Gerena; Wilbur K Milhous; Akintunde Sowunmi; Ayoade Oduola; Lateef A Salako
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.
Annals of tropical medicine and parasitology 2006;100(7):571-8.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Olayinka M Bolaji; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.
The American journal of tropical medicine and hygiene 2006;75(1):155-61.
2006: Igor Opsenica; Natasa Terzić; Dejan Opsenica; Goran Angelovski; Manfred Lehnig; Peter Eilbracht; Bernard Tinant; Zorica Juranić; Kirsten S Smith; Young S Yang; Damaris S Diaz; Philip L Smith; Wilbur K Milhous; Dejan Doković; Bogdan A Solaja
Tetraoxane antimalarials and their reaction with Fe(II).
Journal of medicinal chemistry 2006;49(13):3790-9.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Danny Milner; Ousmane Sarr; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.
Malaria journal 2006;5():82.
2005: Quan Zhang; Jian Guan; John B Sacci; Arba Ager; William Ellis; Wilbur K Milhous; Dennis Kyle; Ai J Lin
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives.
Journal of medicinal chemistry 2005;48(20):6472-81.
2005: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Dora O Akinboye; Bidemi O Yusuf; OO Ebong; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria.
Acta tropica 2005;95(3):183-93.
2005: Ernest J Mui; David P Jacobus; Wilbur K Milhous; Guy A Schiehser; Honghue Hsu; Craig William Roberts; Michael J Kirisits; Rima McLeod
Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo.
Antimicrobial agents and chemotherapy 2005;49(8):3463-7.
2005: Todd W Shearer; Michael P Kozar; Michael T O'Neil; Philip L Smith; Guy A Schiehser; David P Jacobus; Damaris S Diaz; Young-Sun Yang; Wilbur K Milhous; Donald R Skillman
In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
Journal of medicinal chemistry 2005;48(8):2805-13.
2005: Jian Guan; Quan Zhang; Gettayacamin Montip; Jean M Karle; Charles A DiTusa; Wilbur K Milhous; Donald R Skillman; Ai J Lin
Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives.
Bioorganic & medicinal chemistry 2005;13(3):699-704.
2004: Qigui Li; Charles B Lugt; Sornchai Looareesuwan; Srivicha Krudsood; Polrat Wilairatana; Suparp Vannaphan; Kobsiri Chalearmrult; Wilbur K Milhous
Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 2004;71(6):723-31.
2004: Craig William Roberts; Fiona Roberts; Fiona Henriquez; Donna E Akiyoshi; Benjamin Udayakumar Samuel; Thomas A Richards; Wilbur K Milhous; Dennis Kyle; Lee McIntosh; George C Hill; Minu Chaudhuri; Saul Tzipori; Rima McLeod
Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target.
International journal for parasitology 2004;34(3):297-308.
2004: Apurba K Bhattacharjee; Mark G Hartell; Daniel A Nichols; Rickey P Hicks; Benjamin Stanton; John E van Hamont; Wilbur K Milhous
Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates.
European journal of medicinal chemistry 2004;39(1):59-67.
2004: Christian T Happi; Grace O Gbotosho; Akintunde Sowunmi; Catherine O Falade; Dora O Akinboye; Lucia Gerena; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.
The American journal of tropical medicine and hygiene 2004;70(1):20-6.
2003: Dejan Opsenica; Goran Angelovski; Gabriella Pocsfalvi; Zorica Juranić; Zeljko Zizak; Dennis Kyle; Wilbur K Milhous; Bogdan A Solaja
Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes.
Bioorganic & medicinal chemistry 2003;11(13):2761-8.
2003: TC Happi; S M Thomas; Grace O Gbotosho; Catherine O Falade; Dora O Akinboye; Lucia Gerena; T Hudson; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.
Annals of tropical medicine and parasitology 2003;97(5):439-51.
2002: Apurba K Bhattacharjee; Dennis E Kyle; Jonathan L Vennerstrom; Wilbur K Milhous
A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal.
Journal of chemical information and computer sciences 2002;42(5):1212-20.
2002: Bogdan A Solaja; Natasa Terzić; Gabriella Pocsfalvi; Lucia Gerena; Bernard Tinant; Dejan Opsenica; Wilbur K Milhous
Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity.
Journal of medicinal chemistry 2002;45(16):3331-6.
2002: Michael A Riel; Dennis E Kyle; Apurba K Bhattacharjee; Wilbur K Milhous
Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores.
Antimicrobial agents and chemotherapy 2002;46(8):2627-32.
2002: Colin Ohrt; George D Willingmyre; Patricia Lee; Charles Knirsch; Wilbur K Milhous
Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro.
Antimicrobial agents and chemotherapy 2002;46(8):2518-24.
2002: Jian Guan; Dennis E Kyle; Lucia Gerena; Quan Zhang; Wilbur K Milhous; Ai J Lin
Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.
Journal of medicinal chemistry 2002;45(13):2741-8.
2002: QG Li; Steven R Mog; Y Z Si; Dennis E Kyle; Montip Gettayacamin; Wilbur K Milhous
Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents.
The American journal of tropical medicine and hygiene 2002;66(5):516-25.
2002: Michael A Riel; Dennis E Kyle; Wilbur K Milhous
Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro.
Journal of natural products 2002;65(4):614-5.
2002: Craig William Roberts; Fiona Roberts; Russell E Lyons; Michael J Kirisits; Ernest J Mui; John Finnerty; Jennifer J Johnson; David J P Ferguson; John R Coggins; Tino Krell; Graham H Coombs; Wilbur K Milhous; Dennis E Kyle; Saul Tzipori; John W Barnwell; John B Dame; Jane Carlton; Rima McLeod
The shikimate pathway and its branches in apicomplexan parasites.
The Journal of infectious diseases 2002;185 Suppl 1():S25-36.
2002: Pent Zhang; Diarmuid E Nicholson; Janusz Bujnicki; Xinzhuan Su; James J Brendle; Michael Ferdig; Dennis E Kyle; Wilbur K Milhous; Peter K Chiang
Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Journal of biomedical science 2002;9(1):34-40.
2001: Rima McLeod; Stephen P Muench; John B Rafferty; Dennis E Kyle; Ernest J Mui; Michael J Kirisits; Doug Mack; Craig William Roberts; Benjamin Udayakumar Samuel; Russell E Lyons; M Dorris; Wilbur K Milhous; David Rice
Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
International journal for parasitology 2001;31(2):109-13.
2001: Wilbur K Milhous
Development of new drugs for chemoprophylaxis of malaria.
Médecine tropicale : revue du Corps de santé colonial 2001;61(1):48-50.
2000: Dejan Opsenica; Gabriella Pocsfalvi; Zorica Juranic; Bernard Tinant; Jean-Paul Declercq; Dennis E Kyle; Wilbur K Milhous; Bogdan A Solaja
Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity.
Journal of medicinal chemistry 2000;43(17):3274-82.
2000: Jonathan L Vennerstrom; Yuxiang Dong; SL Andersen; Arba Ager; H Fu; R E Miller; D L Wesche; Dennis E Kyle; Lucia Gerena; S M Walters; James K Wood; G Edwards; A D Holme; W Graham McLean; Wilbur K Milhous
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
Journal of medicinal chemistry 2000;43(14):2753-8.
2000: Kevin J McCullough; James K Wood; Apurba K Bhattacharjee; Yuxiang Dong; Dennis E Kyle; Wilbur K Milhous; Jonathan L Vennerstrom
Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.
Journal of medicinal chemistry 2000;43(6):1246-9.
1999: Douglas S Walsh; Sornchai Looareesuwan; Polrat Wilairatana; Donald Heppner; Douglas B Tang; Thomas G Brewer; Watcharee Chokejindachai; Parnpen Viriyavejakul; Dennis E Kyle; Wilbur K Milhous; BG Schuster; Richard John Horton; David Braitman; RP Brueckner
Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.
The Journal of infectious diseases 1999;180(4):1282-7.
1999: Jonathan L Vennerstrom; E O Nuzum; R E Miller; Arnulf Dorn; Lucia Gerena; Prasad Dande; William Y Ellis; RG Ridley; Wilbur K Milhous
8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization.
Antimicrobial agents and chemotherapy 1999;43(3):598-602.
1998: Jonathan L Vennerstrom; Arba Ager; Arnulf Dorn; SL Andersen; Lucia Gerena; RG Ridley; Wilbur K Milhous
Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.
Journal of medicinal chemistry 1998;41(22):4360-4.
1998: Michael T Makler; Robert C Piper; Wilbur K Milhous
Lactate dehydrogenase and the diagnosis of malaria.
Parasitology today (Personal ed.) 1998;14(9):376-7.
1998: Fiona Roberts; Craig William Roberts; Jennifer J Johnson; Dennis E Kyle; Tino Krell; John R Coggins; Graham H Coombs; Wilbur K Milhous; Saul Tzipori; David J P Ferguson; Debopam Chakrabarti; Rima McLeod
Evidence for the shikimate pathway in apicomplexan parasites.
Nature 1998;393(6687):801-5.
1998: Mariano G Zalis; L Pang; Mariana S Silveira; Wilbur K Milhous; D F Wirth
Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance.
The American journal of tropical medicine and hygiene 1998;58(5):630-7.
1998: Ayoade Oduola; Akintunde Sowunmi; Wilbur K Milhous; Thomas G Brewer; Dennis E Kyle; Lucia Gerena; RN Rossan; Lateef A Salako; BG Schuster
In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.
The American journal of tropical medicine and hygiene 1998;58(5):625-9.
1997: Ayoade Oduola; G O Omitowoju; Akintunde Sowunmi; Michael T Makler; Catherine O Falade; Dennis E Kyle; Fatai A Fehintola; O A T Ogundahunsi; Robert C Piper; BG Schuster; Wilbur K Milhous
Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.
Experimental parasitology 1997;87(3):283-9.
1994: Gary H Posner; C H Oh; D Wang; Lucia Gerena; Wilbur K Milhous; Steven R Meshnick; W Asawamahasadka
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.
Journal of medicinal chemistry 1994;37(9):1256-8.
1994: Leonardo K Basco; S L Andersen; Wilbur K Milhous; Jacques Le Bras; Jonathan L Vennerstrom
In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1994;50(2):200-5.
1993: Y Maeno; T Toyoshima; H Fujioka; Y Ito; Steven R Meshnick; A Benakis; Wilbur K Milhous; M Aikawa
Morphologic effects of artemisinin in Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1993;49(4):485-91.
1993: CJ Canfield; Wilbur K Milhous; Arba Ager; RN Rossan; T R Sweeney; N J Lewis; D P Jacobus
PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.
The American journal of tropical medicine and hygiene 1993;49(1):121-6.
1993: D De; Amiya P Bhaduri; Wilbur K Milhous
A novel pyrrolidonoalkaneamine (WR268954) that modulates chloroquine resistance of Plasmodium falciparum in vitro.
The American journal of tropical medicine and hygiene 1993;49(1):113-20.
1993: Jean M Karle; R Olmeda; Lucia Gerena; Wilbur K Milhous
Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents.
Experimental parasitology 1993;76(4):345-51.
1993: B G Schuster; Wilbur K Milhous
Reduced resources applied to antimalarial drug development.
Parasitology today (Personal ed.) 1993;9(5):167-8.
1993: M J Shmuklarsky; D L Klayman; Wilbur K Milhous; Dennis E Kyle; RN Rossan; Arba Ager; D B Tang; M H Heiffer; CJ Canfield; BG Schuster
Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.
The American journal of tropical medicine and hygiene 1993;48(3):377-84.
1993: Ayoade Oduola; G O Omitowoju; Lucia Gerena; Dennis E Kyle; Wilbur K Milhous; Akintunde Sowunmi; Lateef A Salako
Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1993;87(1):81-3.
1993: Dennis E Kyle; Wilbur K Milhous; RN Rossan
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
The American journal of tropical medicine and hygiene 1993;48(1):126-33.
1993: C M Wilson; Sarah K Volkman; Sodsri Thaithong; R K Martin; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth
Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.
Molecular and biochemical parasitology 1993;57(1):151-60.
1992: Lucia Gerena; G T Bass; Dennis E Kyle; Ayoade Oduola; Wilbur K Milhous; R K Martin
Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1992;36(12):2761-5.
1992: Jonathan L Vennerstrom; H N Fu; William Y Ellis; Arba Ager; J K Wood; S L Andersen; Lucia Gerena; Wilbur K Milhous
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
Journal of medicinal chemistry 1992;35(16):3023-7.
1992: Jean M Karle; I L Karle; Lucia Gerena; Wilbur K Milhous
Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1992;36(7):1538-44.
1992: Gary H Posner; C H Oh; Lucia Gerena; Wilbur K Milhous
Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes.
Journal of medicinal chemistry 1992;35(13):2459-67.
1992: Jonathan L Vennerstrom; William Y Ellis; Arba Ager; S L Andersen; Lucia Gerena; Wilbur K Milhous
Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria.
Journal of medicinal chemistry 1992;35(11):2129-34.
1992: Sherry F Queener; RA Dean; Marilyn S Bartlett; Wilbur K Milhous; Jonathan D Berman; William Y Ellis; James W Smith
Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats.
The Journal of infectious diseases 1992;165(4):764-8.
1992: Ayoade Oduola; Akintunde Sowunmi; Wilbur K Milhous; Dennis E Kyle; R K Martin; O Walker; Lateef A Salako
Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86(2):123-6.
1991: Max Grogl; R K Martin; Ayoade Oduola; Wilbur K Milhous; Dennis E Kyle
Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components.
The American journal of tropical medicine and hygiene 1991;45(1):98-111.
1991: G E Childs; E F Bourdeau; T Wimonwattratee; L Pang; Wilbur K Milhous
In vitro and clinical correlates of mefloquine resistance of Plasmodium falciparum in eastern Thailand.
The American journal of tropical medicine and hygiene 1991;44(5):553-9.
1991: Marilyn S Bartlett; Sherry F Queener; Richard R Tidwell; Wilbur K Milhous; Jonathan D Berman; William Y Ellis; James W Smith
8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models.
Antimicrobial agents and chemotherapy 1991;35(2):277-82.
1991: G P Willet; Wilbur K Milhous; Lucia Gerena; Ayoade Oduola
Mixed population dynamics in human malaria parasite cultures.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1991;85(1):33-4.
1990: Dennis E Kyle; Ayoade Oduola; S K Martin; Wilbur K Milhous
Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(4):474-8.
1989: Ayoade Oduola; R S Moyou-Somo; Dennis E Kyle; S K Martin; Lucia Gerena; Wilbur K Milhous
Chloroquine resistant Plasmodium falciparum in indigenous residents of Cameroon.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(3):308-10.
1989: Wilbur K Milhous; Lucia Gerena; Dennis E Kyle; Ayoade Oduola
In vitro strategies for circumventing antimalarial drug resistance.
Progress in clinical and biological research 1989;313():61-72.
1989: G E Childs; E F Boudreau; Wilbur K Milhous; T Wimonwattratee; N Pooyindee; L Pang; D E Davidson
A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1989;40(1):7-11.
1988: Alan J Bitonti; A Sjoerdsma; P P McCann; Dennis E Kyle; Ayoade Oduola; RN Rossan; Wilbur K Milhous; D E Davidson
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.
Science (New York, N.Y.) 1988;242(4883):1301-3.
1988: Ayoade Oduola; Wilbur K Milhous; N F Weatherly; J H Bowdre; R E Desjardins
Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro.
Experimental parasitology 1988;67(2):354-60.
1988: G H Jacobs; Ayoade Oduola; Dennis E Kyle; Wilbur K Milhous; S K Martin; M Aikawa
Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1988;39(1):15-20.
1988: G E Childs; B Häusler; Wilbur K Milhous; C Chen; Theera Wimonwattrawatee; N Pooyindee; E F Boudreau
In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1988;38(1):24-9.
1987: Ayoade Oduola; Wilbur K Milhous; L A Salako; O Walker; R E Desjardins
Reduced in-vitro susceptibility to mefloquine in West African isolates of Plasmodium falciparum.
Lancet 1987;2(8571):1304-5.
1987: D J Krogstad; Ilya Y Gluzman; Dennis E Kyle; Ayoade Oduola; S K Martin; Wilbur K Milhous; P H Schlesinger
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
Science (New York, N.Y.) 1987;238(4831):1283-5.
1987: Ai J Lin; D L Klayman; Wilbur K Milhous
Antimalarial activity of new water-soluble dihydroartemisinin derivatives.
Journal of medicinal chemistry 1987;30(11):2147-50.
1987: S K Martin; Ayoade Oduola; Wilbur K Milhous
Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.
Science (New York, N.Y.) 1987;235(4791):899-901.
1985: Wilbur K Milhous; N F Weatherly; J H Bowdre; R E Desjardins
In vitro activities of and mechanisms of resistance to antifol antimalarial drugs.
Antimicrobial agents and chemotherapy 1985;27(4):525-30.
1984: D L Klayman; Ai J Lin; N Acton; J P Scovill; J M Hoch; Wilbur K Milhous; A D Theoharides; A S Dobek
Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States.
Journal of natural products 1984;47(4):715-7.