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José Luis Millán

Research Profile

Chemicals & Drugs

Living Beings

Disorders

Hypophosphatasia

Physiology

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Anatomy

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Amino Acid Sequences

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Publications

TOP 3
Betty Hoac; Tina Kiffer-Moreira; José Luis Millán; Marc D McKee
Polyphosphates inhibit extracellular matrix mineralization in MC3T3-E1 osteoblast cultures.
Jesse E Otero; Campbell Sheen; Karen L Ericson; Gary S Gottesman; Tina Kiffer-Moreira; Katherine L Madson; William H McAlister; José Luis Millán; Steven Mumm; Michael P Whyte
Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy.
Tina Kiffer-Moreira; Vicky E Macrae; Nicholas D Cosford; Russell Dahl; Colin Farquharson; Marc F Hoylaerts; Sonoko Narisawa; Campbell Sheen; Boguslaw Stec; Manisha C Yadav; Dongxing Zhu; José Luis Millán
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.

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All Publications

2013: Betty Hoac; Tina Kiffer-Moreira; José Luis Millán; Marc D McKee
Polyphosphates inhibit extracellular matrix mineralization in MC3T3-E1 osteoblast cultures.
Bone 2013;53(2):478-86.
2013: Jesse E Otero; Campbell Sheen; Karen L Ericson; Gary S Gottesman; Tina Kiffer-Moreira; Katherine L Madson; William H McAlister; José Luis Millán; Steven Mumm; Michael P Whyte
Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(2):419-30.
2013: Tina Kiffer-Moreira; Vicky E Macrae; Nicholas D Cosford; Russell Dahl; Colin Farquharson; Marc F Hoylaerts; Sonoko Narisawa; Campbell Sheen; Boguslaw Stec; Manisha C Yadav; Dongxing Zhu; José Luis Millán
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):81-91.
2011: M Bolean; B Z Favarin; José Luis Millán; A M S Simão; Pietro Ciancaglini
Thermodynamic properties and characterization of proteoliposomes rich in microdomains carrying alkaline phosphatase.
Biophysical chemistry 2011;158(2-3):111-8.
2010: M Bolean; A M S Simão; B Z Favarin; José Luis Millán; Pietro Ciancaglini
The effect of cholesterol on the reconstitution of alkaline phosphatase into liposomes.
Biophysical chemistry 2010;152(1-3):74-9.
2010: Ana Maria S Simão; Manisha C Yadav; Sonoko Narisawa; Mayte Bolean; Joao Martins Pizauro; Marc F Hoylaerts; Pietro Ciancaglini; José Luis Millán
Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics.
The Journal of biological chemistry 2010;285(10):7598-609.
2009: Russell Dahl; Eduard A Sergienko; Ying Su; Yalda S Mostofi; Li Yang; Ana Maria Simao; Sonoko Narisawa; Brock Brown; Arianna Mangravita-Novo; Michael Vicchiarelli; Layton H Smith; W Charles O'Neill; José Luis Millán; Nicholas D P Cosford
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Journal of medicinal chemistry 2009;52(21):6919-25.
2009: Cecilia Halling Linder; Sonoko Narisawa; José Luis Millán; Per Magnusson
Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms.
Bone 2009;45(5):987-93.
2009: Shyama Sidique; Robert Ardecky; Ying Su; Sonoko Narisawa; Brock Brown; José Luis Millán; Eduard Sergienko; Nicholas Cosford
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Bioorganic & medicinal chemistry letters 2009;19(1):222-5.
2008: José Luis Millán; Sonoko Narisawa; Isabelle Lemire; Thomas P Loisel; Guy Boileau; Pierre Leonard; Svetlana Gramatikova; Robert Terkeltaub; Nancy Pleshko Camacho; Marc McKee; Philippe Crine; Michael P Whyte
Enzyme replacement therapy for murine hypophosphatasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(6):777-87.
2007: Sonoko Narisawa; Marc F Hoylaerts; Kutbuddin S Doctor; Michiko N Fukuda; David H Alpers; José Luis Millán
A novel phosphatase upregulated in Akp3 knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G1068-77.
2007: Sonoko Narisawa; Dympna Harmey; Manisha C Yadav; W Charles O'Neill; Marc F Hoylaerts; José Luis Millán
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(11):1700-10.
2007: Takanari Nakano; Ikuo Inoue; Iwao Koyama; Kenta Kanazawa; Koh-Ichi Nakamura; Sonoko Narisawa; Kayoko Tanaka; Masumi Akita; Taku Masuyama; Makoto Seo; Shigeru Hokari; Shigehiro Katayama; David H Alpers; José Luis Millán; Tsugikazu Komoda
Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(5):G1439-49.
2007: Scott Roberts; Sonoko Narisawa; Dympna Harmey; José Luis Millán; Colin Farquharson
Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(4):617-27.
2007: Uma Vempati; Francisca Diaz; Antoni Barrientos; Sonoko Narisawa; Abdul M Mian; José Luis Millán; Lawrence Boise; Carlos T Moraes
Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release.
Molecular and cellular biology 2007;27(5):1771-83.
2006: Dympna Harmey; Kristen A Johnson; Jonathan Zelken; Nancy P Camacho; Marc F Hoylaerts; Masaki Noda; Robert Terkeltaub; José Luis Millán
Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(9):1377-86.
2006: Pietro Ciancaglini; A M S Simão; F L Camolezi; José Luis Millán; João M Pizauro
Contribution of matrix vesicles and alkaline phosphatase to ectopic bone formation.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2006;39(5):603-10.
2005: Paola Llinas; Enrico A Stura; André Ménez; Zoltan Kiss; Torgny Stigbrand; José Luis Millán; Marie Hélène Le Du
Structural studies of human placental alkaline phosphatase in complex with functional ligands.
Journal of molecular biology 2005;350(3):441-51.
2005: H Clarke Anderson; Dympna Harmey; Nancy P Camacho; Rama Garimella; Joseph B Sipe; Sarah Tague; Xiaohong Bi; Kristen Johnson; Robert Terkeltaub; José Luis Millán
Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.
The American journal of pathology 2005;166(6):1711-20.
2005: Sonoko Narisawa; Dympna Harmey; Per Magnusson; José Luis Millán
Conserved epitopes in human and mouse tissue-nonspecific alkaline phosphatase. Second report of the ISOBM TD-9 workshop.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(3):113-20.
2005: Monzur Murshed; Dympna Harmey; José Luis Millán; Marc McKee; Gerard Karsenty
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone.
Genes & development 2005;19(9):1093-104.
2004: Alexey Kozlenkov; Marie Helene Le Du; Philippe Cuniasse; Tor Ny; Marc F Hoylaerts; José Luis Millán
Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1862-72.
2004: Dympna Harmey; Lovisa Hessle; Sonoko Narisawa; Kristen A Johnson; Robert Terkeltaub; José Luis Millán
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
The American journal of pathology 2004;164(4):1199-209.
2004: H Clarke Anderson; Joseph B Sipe; Lovisa Hessle; Rama Dhanyamraju; Elisa Atti; Nancy P Camacho; José Luis Millán; Rama Dhamyamraju
Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.
The American journal of pathology 2004;164(3):841-7.
2003: Per Olsson; Hiroshi Tsujioka; Sonoko Narisawa; Erwin Goldberg; José Luis Millán
Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene.
Journal of andrology 2003;24(6):918-20.
2003: Sonoko Narisawa; Lei Huang; Arata Iwasaki; Hideaki Hasegawa; David H Alpers; José Luis Millán
Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.
Molecular and cellular biology 2003;23(21):7525-30.
2003: Helge Weissig; Sonoko Narisawa; Carin Sikström; Per Olsson; John R McCarrey; Panagiotis A Tsonis; Katia Del Rio-Tsonis; José Luis Millán
Three novel spermatogenesis-specific zinc finger genes.
FEBS letters 2003;547(1-3):61-8.
2003: Kristen Johnson; James W Goding; Deborah van Etten; Adnan Sali; Shou-Ih Hu; David Farley; Hollis Krug; Lovisa Hessle; José Luis Millán; Robert Terkeltaub
Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(6):994-1004.
2002: Sonia Di Mauro; Thomas Manes; Lovisa Hessle; Alexey Kozlenkov; João M Pizauro; Marc F Hoylaerts; José Luis Millán
Kinetic characterization of hypophosphatasia mutations with physiological substrates.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(8):1383-91.
2002: Sonoko Narisawa; Norman B Hecht; Erwin Goldberg; Kelly M Boatright; John C Reed; José Luis Millán
Testis-specific cytochrome c-null mice produce functional sperm but undergo early testicular atrophy.
Molecular and cellular biology 2002;22(15):5554-62.
2002: Per Magnusson; L Arlestig; Elisabeth Paus; Sonia Di Mauro; M P Testa; Torgny Stigbrand; John R Farley; Kjell Nustad; José Luis Millán
Monoclonal antibodies against tissue-nonspecific alkaline phosphatase. Report of the ISOBM TD9 workshop.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2002;23(4):228-48.
2002: Alexey Kozlenkov; Thomas Manes; Marc F Hoylaerts; José Luis Millán
Function assignment to conserved residues in mammalian alkaline phosphatases.
The Journal of biological chemistry 2002;277(25):22992-9.
2002: Gaetano Zafarana; Ad J M Gillis; Ruud van Gurp; Per Olsson; Fons Elstrodt; hans stoop; José Luis Millán; J Wolter Oosterhuis; Leendert H J Looijenga
Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.
Cancer research 2002;62(6):1822-31.
2002: Charlotte Wennberg; Alexey Kozlenkov; Sonia Di Mauro; Nils Fröhlander; Lars Beckman; Marc F Hoylaerts; José Luis Millán
Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP).
Human mutation 2002;19(3):258-67.
2001: Sonoko Narisawa; Charlotte Wennberg; José Luis Millán
Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization.
The Journal of pathology 2001;193(1):125-33.
2000: Charlotte Wennberg; Lovisa Hessle; Pernilla Lundberg; S Mauro; Sonoko Narisawa; Ulf H Lerner; José Luis Millán
Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(10):1879-88.
2000: Hesam Dehghani; Sonoko Narisawa; José Luis Millán; Ann C Hahnel
Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;217(4):440-8.
1999: Kenton Fedde; L Blair; J Silverstein; Stephen P Coburn; Lawrence M Ryan; R S Weinstein; Katrina G Waymire; Sonoko Narisawa; José Luis Millán; G R MacGregor; Michael P Whyte
Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(12):2015-26.
1999: K A Smans; M B Ingvarsson; P Lindgren; S Canevari; H Walt; Torgny Stigbrand; T Bäckström; José Luis Millán
Bispecific antibody-mediated lysis of primary cultures of ovarian carcinoma cells using multiple target antigens.
International journal of cancer. Journal international du cancer 1999;83(2):270-7.
1999: H Roelofs; Thomas Manes; T Janszen; José Luis Millán; J Wolter Oosterhuis; Leendert H J Looijenga
Heterogeneity in alkaline phosphatase isozyme expression in human testicular germ cell tumours: An enzyme-/immunohistochemical and molecular analysis.
The Journal of pathology 1999;189(2):236-44.
1998: Thomas Manes; Marc F Hoylaerts; R Müller; F Lottspeich; W Hölke; José Luis Millán
Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases.
The Journal of biological chemistry 1998;273(36):23353-60.
1997: Marc F Hoylaerts; Thomas Manes; José Luis Millán
Mammalian alkaline phosphatases are allosteric enzymes.
The Journal of biological chemistry 1997;272(36):22781-7.
1997: Sonoko Narisawa; N Fröhlander; José Luis Millán
Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(3):432-46.
1996: Peter W Andrews; J Casper; Ivan Damjanov; M Duggan-Keen; A Giwercman; J Hata; A von Keitz; Leendert H J Looijenga; José Luis Millán; J W Oosterhuis; M Pera; M Sawada; H J Schmoll; N E Skakkebaek; W van Putten; Peter L Stern
Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours.
International journal of cancer. Journal international du cancer 1996;66(6):806-16.
1995: K A Smans; M F Hoylaerts; Sonoko Narisawa; José Luis Millán; Marc E De Broe
Bispecific antibody-mediated lysis of placental and germ cell alkaline phosphatase targeted solid tumors in immunocompetent mice.
Cancer research 1995;55(19):4383-90.
1995: K Crawford; H Weissig; F Binette; José Luis Millán; Paul F Goetinck
Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;204(1):48-56.
1995: Marie-Claude Hofmann; D Abramian; José Luis Millán
A haploid and a diploid cell coexist in an in vitro immortalized spermatogenic cell line.
Developmental genetics 1995;16(2):119-27.
1994: Sonoko Narisawa; H Hasegawa; K Watanabe; José Luis Millán
Stage-specific expression of alkaline phosphatase during neural development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 1994;201(3):227-35.
1994: Marie-Claude Hofmann; Rex Allen Hess; Erwin Goldberg; José Luis Millán
Immortalized germ cells undergo meiosis in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5533-7.
1993: M Bossi; M F Hoylaerts; José Luis Millán
Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases.
The Journal of biological chemistry 1993;268(34):25409-16.
1993: Sonoko Narisawa; K A Smans; J Avis; M F Hoylaerts; José Luis Millán
Transgenic mice expressing the tumor marker germ cell alkaline phosphatase: an in vivo tumor model for human cancer antigens.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5081-5.
1993: L A Cooker; C D Brooke; M Kumari; Marie-Claude Hofmann; José Luis Millán; Erwin Goldberg
Genomic structure and promoter activity of the human testis lactate dehydrogenase gene.
Biology of reproduction 1993;48(6):1309-19.
1993: H Weissig; A Schildge; M F Hoylaerts; M Iqbal; José Luis Millán
Cloning and expression of the bovine intestinal alkaline phosphatase gene: biochemical characterization of the recombinant enzyme.
The Biochemical journal 1993;290 ( Pt 2)():503-8.
1993: Marie-Claude Hofmann; José Luis Millán
Developmental expression of alkaline phosphatase genes; reexpression in germ cell tumours and in vitro immortalized germ cells.
European urology 1993;23(1):38-44; discussion 45.
1992: M F Hoylaerts; Thomas Manes; José Luis Millán
Allelic amino acid substitutions affect the conformation and immunoreactivity of germ-cell alkaline phosphatase phenotypes.
Clinical chemistry 1992;38(12):2493-500.
1992: Sonoko Narisawa; Marie-Claude Hofmann; C A Ziomek; José Luis Millán
Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse.
Development (Cambridge, England) 1992;116(1):159-65.
1992: M F Hoylaerts; Thomas Manes; José Luis Millán
Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase.
The Biochemical journal 1992;286 ( Pt 1)():23-30.
1992: Marie-Claude Hofmann; Sonoko Narisawa; Rex Allen Hess; José Luis Millán
Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen.
Experimental cell research 1992;201(2):417-35.
1992: José Luis Millán
Alkaline phosphatase as a reporter of cancerous transformation.
Clinica chimica acta; international journal of clinical chemistry 1992;209(1-2):123-9.
1991: M F Hoylaerts; José Luis Millán
Site-directed mutagenesis and epitope-mapped monoclonal antibodies define a catalytically important conformational difference between human placental and germ cell alkaline phosphatase.
European journal of biochemistry / FEBS 1991;202(2):605-16.
1991: N Fröhlander; José Luis Millán
Alkaline phosphatases as reporters of developmental and cancerous events.
In vivo (Athens, Greece) 1991;5(5):483-8.
1991: C Hummer; José Luis Millán
Gly429 is the major determinant of uncompetitive inhibition of human germ cell alkaline phosphatase by L-leucine.
The Biochemical journal 1991;274 ( Pt 1)():91-5.
1990: Thomas Manes; K Glade; C A Ziomek; José Luis Millán
Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.
Genomics 1990;8(3):541-54.
1990: Sonoko Narisawa; J M Sowadski; José Luis Millán
An active site mutant of human placental alkaline phosphatase with deficient enzymatic activity and preserved immunoreactivity.
Clinica chimica acta; international journal of clinical chemistry 1990;186(2):189-96.
1990: José Luis Millán
Oncodevelopmental alkaline phosphatases: in search for a function.
Progress in clinical and biological research 1990;344():453-75.
1988: José Luis Millán; Thomas Manes
Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3024-8.