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Kirsty Millar

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Chemicals & Drugs

Disorders

Physiology

Anatomy

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Publications

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Dinesh C Soares; Malcolm D Walkinshaw; Martin A Wear; Juan Zou; Juri Rappsilber; Paul N Barlow; Elizabeth A Blackburn; Bettina Böttcher; Nicholas Bradshaw; Janice Bramham; Zhuo A Chen; Russell S Hamilton; Christopher K Kennaway; J Kirsty Millar; David J Porteous
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
Jennifer E Eykelenboom; Shaun Mackie; Paraskevi Makedonopoulou; Elise L V Malavasi; Mary P Malloy; Andrew M McIntosh; Elizabeth A Blackburn; Douglas H Blackwood; Nicholas J Bradshaw; Janice Bramham; Gareth J Briggs; Sheila Christie; Walter J Muir; Fumiaki Ogawa; David J Porteous; Dinesh C Soares; Martin A Wear; J Kirsty Millar
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Elise L V Malavasi; Fumiaki Ogawa; David J Porteous; J Kirsty Millar
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.

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All Publications

2012: Dinesh C Soares; Malcolm D Walkinshaw; Martin A Wear; Juan Zou; Juri Rappsilber; Paul N Barlow; Elizabeth A Blackburn; Bettina Böttcher; Nicholas Bradshaw; Janice Bramham; Zhuo A Chen; Russell S Hamilton; Christopher K Kennaway; J Kirsty Millar; David J Porteous
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
The Journal of biological chemistry 2012;287(39):32381-93.
2012: Jennifer E Eykelenboom; Shaun Mackie; Paraskevi Makedonopoulou; Elise L V Malavasi; Mary P Malloy; Andrew M McIntosh; Elizabeth A Blackburn; Douglas H Blackwood; Nicholas J Bradshaw; Janice Bramham; Gareth J Briggs; Sheila Christie; Walter J Muir; Fumiaki Ogawa; David J Porteous; Dinesh C Soares; Martin A Wear; J Kirsty Millar
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Human molecular genetics 2012;21(15):3374-86.
2012: Elise L V Malavasi; Fumiaki Ogawa; David J Porteous; J Kirsty Millar
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
Human molecular genetics 2012;21(12):2779-92.
2011: David J Porteous; Nicholas J Brandon; J Kirsty Millar; Akira Sawa
DISC1 at 10: connecting psychiatric genetics and neuroscience.
Trends in molecular medicine 2011;17(12):699-706.
2011: B C Carlyle; S Christie; S Mackie; J Kirsty Millar; D J Porteous
Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling.
Molecular psychiatry 2011;16(7):693-4.
2011: Nicholas Bradshaw; Becky C Carlyle; Sheila Christie; Hazel Davidson-Smith; Shaun Mackie; Fumiaki Ogawa; David J Porteous; Dinesh C Soares; Pippa A Thomson; J Kirsty Millar
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(24):9043-54.
2009: Nicholas J Brandon; J Kirsty Millar; Carsten Korth; Hazel Sive; Karun K Singh; Akira Sawa
Understanding the role of DISC1 in psychiatric disease and during normal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12768-75.
2008: Nicholas Bradshaw; Fumiaki Ogawa; Beatriz Antolin-Fontes; Jennifer E Chubb; Becky C Carlyle; Sheila Christie; Antoine Claessens; David J Porteous; J Kirsty Millar
DISC1, PDE4B, and NDE1 at the centrosome and synapse.
Biochemical and biophysical research communications 2008;377(4):1091-6.
2008: J E Chubb; Nicholas Bradshaw; D C Soares; D J Porteous; J Kirsty Millar
The DISC locus in psychiatric illness.
Molecular psychiatry 2008;13(1):36-64.
2007: J Kirsty Millar; Shaun Mackie; Steven J Clapcote; Hannah Murdoch; Ben S Pickard; Sheila Christie; Walter J Muir; D H R Blackwood; John C Roder; Miles D Houslay; David J Porteous
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.
The Journal of physiology 2007;584(Pt 2):401-5.
2007: Koko Ishizuka; J Chen; S Taya; W Li; J Kirsty Millar; Y Xu; Steven J Clapcote; C Hookway; M Morita; Atsushi Kamiya; T Tomoda; B K Lipska; John C Roder; Mikhail V Pletnikov; David J Porteous; A J Silva; T D Cannon; K Kaibuchi; Nicholas J Brandon; Daniel R Weinberger; Akira Sawa
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.
Molecular psychiatry 2007;12(10):897-9.
2007: Hannah Murdoch; Shaun Mackie; Daniel M Collins; Elaine V Hill; Graeme B Bolger; Enno Klussmann; David J Porteous; J Kirsty Millar; Miles D Houslay
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9513-24.
2007: Steven J Clapcote; Tatiana Lipina; J Kirsty Millar; Shaun Mackie; Sheila Christie; Fumiaki Ogawa; Jason P Lerch; Keith Trimble; Masashi Uchiyama; Yoshiyuki Sakuraba; Hideki Kaneda; Toshihiko Shiroishi; Miles D Houslay; R Mark Henkelman; John G Sled; Yoichi Gondo; David J Porteous; John C Roder
Behavioral phenotypes of Disc1 missense mutations in mice.
Neuron 2007;54(3):387-402.
2007: Shaun Mackie; J Kirsty Millar; David J Porteous
Role of DISC1 in neural development and schizophrenia.
Current opinion in neurobiology 2007;17(1):95-102.
2006: David J Porteous; Pippa Thomson; Nicholas J Brandon; J Kirsty Millar
The genetics and biology of DISC1--an emerging role in psychosis and cognition.
Biological psychiatry 2006;60(2):123-31.
2006: David J Porteous; J Kirsty Millar
Disrupted in schizophrenia 1: building brains and memories.
Trends in molecular medicine 2006;12(6):255-61.
2005: J Kirsty Millar; Rachel James; Sheila Christie; David J Porteous
Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.
Molecular and cellular neurosciences 2005;30(4):477-84.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Pippa A Thomson; Naomi R Wray; J Kirsty Millar; Kathryn L Evans; S Le Hellard; A Condie; Walter J Muir; D H R Blackwood; David J Porteous
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.
Molecular psychiatry 2005;10(7):657-68, 616.
2005: Nicholas J Brandon; Irina Schurov; L Miguel Camargo; EJ Handford; B Duran-Jimeniz; P Hunt; J Kirsty Millar; David J Porteous; Mark S Shearman; Paul J Whiting
Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.
Molecular and cellular neurosciences 2005;28(4):613-24.
2005: Ben S Pickard; J Kirsty Millar; David J Porteous; W J Muir; D H R Blackwood
Cytogenetics and gene discovery in psychiatric disorders.
The pharmacogenomics journal 2005;5(2):81-8.
2004: Stuart Macgregor; Peter M Visscher; Sara A Knott; P Thomson; David J Porteous; J Kirsty Millar; Rebecca S Devon; D H R Blackwood; Walter J Muir
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.
Molecular psychiatry 2004;9(12):1083-90.
2004: Rachel James; Richard R Adams; Sheila Christie; S R Buchanan; David J Porteous; J Kirsty Millar
Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria.
Molecular and cellular neurosciences 2004;26(1):112-22.
2004: J Kirsty Millar; Rachel James; Nicholas J Brandon; Pippa A Thomson
DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness.
Annals of medicine 2004;36(5):367-78.
2003: J Kirsty Millar; Sheila Christie; David J Porteous
Yeast two-hybrid screens implicate DISC1 in brain development and function.
Biochemical and biophysical research communications 2003;311(4):1019-25.
2003: J Kirsty Millar; Pippa A Thomson; Naomi R Wray; Walter J Muir; D H R Blackwood; David J Porteous
Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.
Genetics 2003;163(2):833-5; author reply 837-8.
2003: David J Porteous; Kathryn L Evans; J Kirsty Millar; Ben S Pickard; Pippa A Thomson; R James; S MacGregor; Naomi R Wray; P M Visscher; Walter J Muir; D H R Blackwood
Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes.
Cold Spring Harbor symposia on quantitative biology 2003;68():383-94.
2003: Martin Taylor; Rebecca S Devon; J Kirsty Millar; David J Porteous
Evolutionary constraints on the Disrupted in Schizophrenia locus.
Genomics 2003;81(1):67-77.
2001: Rebecca S Devon; S Anderson; PW Teague; P Burgess; T M Kipari; Colin Semple; J Kirsty Millar; Walter J Muir; V Murray; Anthony Pelosi; D H R Blackwood; David J Porteous
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.
Psychiatric genetics 2001;11(2):71-8.
2001: J Kirsty Millar; S Christie; S Anderson; D Lawson; Dawn Loh; Rebecca S Devon; B Arveiler; Walter J Muir; D H R Blackwood; David J Porteous
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.
Molecular psychiatry 2001;6(2):173-8.
2000: J Kirsty Millar; Sheila Christie; Colin Semple; David J Porteous
Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.
Genomics 2000;67(1):69-77.
2000: J Kirsty Millar; JC Wilson-Annan; S Anderson; Sheila Christie; Martin Taylor; Colin Semple; Rebecca S Devon; D M St Clair; Walter J Muir; D H R Blackwood; David J Porteous
Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Human molecular genetics 2000;9(9):1415-23.
2000: Rebecca S Devon; Martin Taylor; J Kirsty Millar; David J Porteous
Isolation and characterization of the mouse translin-associated protein X (Trax) gene.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(5):395-8.
1998: J Kirsty Millar; J Brown; John Maule; Y Shibasaki; Sheila Christie; D Lawson; S Anderson; JC Wilson-Annan; Rebecca S Devon; D M St Clair; D H R Blackwood; Walter J Muir; David J Porteous
A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes.
Psychiatric genetics 1998;8(3):175-81.
1997: JC Wilson-Annan; D H R Blackwood; Walter Muir; J Kirsty Millar; David J Porteous
An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness.
Psychiatric genetics 1997;7(4):171-4.