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Robert Millar

Research Profile

Chemicals & Drugs

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TOP 3
Colette Meyer; Robert P Millar; Kevin Morgan; Morwenna Muir; Andrew H Sims; Jianing Bai; Dana Faratian; Beth Harrison; Simon P Langdon
Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.
Jacques Young; Javier Tello; Richard A Anderson; Jérôme BOULIGAND; Sylvie Brailly-Tabard; Bruno Francou; Jyothis T George; Anne Guiochon-Mantel; Robert P Millar
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications.
Jyothis T George; Richard A Anderson; Robert P Millar
Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback.

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2013: Colette Meyer; Robert P Millar; Kevin Morgan; Morwenna Muir; Andrew H Sims; Jianing Bai; Dana Faratian; Beth Harrison; Simon P Langdon
Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.
Endocrine-related cancer 2013;20(1):123-36.
2013: Jacques Young; Javier Tello; Richard A Anderson; Jérôme BOULIGAND; Sylvie Brailly-Tabard; Bruno Francou; Jyothis T George; Anne Guiochon-Mantel; Robert P Millar
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications.
Neuroendocrinology 2013;97(2):193-202.
2012: Jyothis T George; Richard A Anderson; Robert P Millar
Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback.
Human reproduction (Oxford, England) 2012;27(12):3552-9.
2012: A K Roseweir; A A Katz; Robert P Millar
Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells.
Placenta 2012;33(5):408-15.
2012: Javier Tello; Jérôme BOULIGAND; Anne Guiochon-Mantel; Robert P Millar; Claire L Newton; Jacques Young
Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling.
PloS one 2012;7(6):e38456.
2011: Jyothis T George; Robert P Millar; C L Newton; A K Roseweir; J D Veldhuis; E Faccenda; Richard A Anderson
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.
The Journal of clinical endocrinology and metabolism 2011;96(8):E1228-36.
2011: Kevin Morgan; Emmanouil Stavrou; Samuel P Leighton; Nicola Miller; Robin Sellar; Robert P Millar
Elevated GnRH receptor expression plus GnRH agonist treatment inhibits the growth of a subset of papillomavirus 18-immortalized human prostate cells.
The Prostate 2011;71(9):915-28.
2011: Claire L Newton; Adele M Whay; Craig A McArdle; Meilin Zhang; Chris J van Koppen; Ruud van de Lagemaat; Deborah L Segaloff; Robert P Millar
Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):7172-6.
2011: Kevin Morgan; Andrew Sims; Colette Meyer; Robert P Millar; Nicola Miller; Ilgin Cagnan; Dana Faratian; David J Harrison; Simon P Langdon
GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines.
BMC cancer 2011;11():476.
2010: Robert P Millar; Antonia K Roseweir; Javier Tello; Richard A Anderson; Jyothis T George; Kevin Morgan; Adam J Pawson
Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology.
Brain research 2010;1364():81-9.
2010: Thayalini Ramaesh; James J Logie; Antonia K Roseweir; Robert P Millar; Brian R Walker; Patrick W F Hadoke; Rebecca M Reynolds
Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.
Endocrinology 2010;151(12):5927-34.
2010: Iain J McEwan; Dagmara McGuinness; Colin W Hay; Robert P Millar; Philippa Saunders; Hamish M Fraser
Identification of androgen receptor phosphorylation in the primate ovary in vivo.
Reproduction (Cambridge, England) 2010;140(1):93-104.
2010: Michal Naidich; Boris Shterntal; Ran Furman; Adam J Pawson; Henry N Jabbour; Kevin Morgan; Robert P Millar; Jingjing Jia; Melanija Tomic; Stanko Stojilkovic; Naftali Stern; Zvi Naor
Elucidation of mechanisms of the reciprocal cross talk between gonadotropin-releasing hormone and prostaglandin receptors.
Endocrinology 2010;151(6):2700-12.
2010: Jyothis T George; Robert P Millar; Richard A Anderson
Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes.
Neuroendocrinology 2010;91(4):302-7.
2009: Nerine T Joseph; Kevin Morgan; Robin Sellar; D McBride; Robert P Millar; Ian C Dunn
The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor.
The Journal of endocrinology 2009;202(1):179-90.
2009: David Maldonado-Pérez; Pamela Brown; Kevin Morgan; Robert P Millar; E Aubrey Thompson; Henry N Jabbour
Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway.
Biochimica et biophysica acta 2009;1793(7):1315-24.
2009: Rebecca M Reynolds; James J Logie; Antonia K Roseweir; Angus J McKnight; Robert P Millar
A role for kisspeptins in pregnancy: facts and speculations.
Reproduction (Cambridge, England) 2009;138(1):1-7.
2009: Antonia K Roseweir; Alexander S Kauffman; Jeremy T Smith; Kathryn A Guerriero; Kevin Morgan; Justyna Pielecka-Fortuna; Rafael Pineda; Michelle L Gottsch; Manuel Tena-Sempere; Sue moenter; Ei Terasawa; Iain J Clarke; Robert A Steiner; Robert P Millar
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3920-9.
2009: Alan James Stewart; Arieh A Katz; Robert P Millar; Kevin Morgan
Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals.
Neuroendocrinology 2009;90(4):416-32.
2008: Marla Coetsee; Robert P Millar; colleen a flanagan; Zhi-Liang Lu
Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation.
Biochemistry 2008;47(39):10305-13.
2008: Kevin Morgan; Alan James Stewart; Nicola Miller; Peter Mullen; Morwenna Muir; Michael Dodds; Federico Medda; David Harrison; Simon Langdon; Robert P Millar
Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo.
Cancer research 2008;68(15):6331-40.
2008: Rakel López de Maturana; Adam J Pawson; Zhi-Liang Lu; Lindsay Davidson; Stuart Maudsley; Kevin Morgan; Simon P Langdon; Robert P Millar
Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1711-22.
2008: Kevin D G Pfleger; Adam J Pawson; Robert P Millar
Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations.
Endocrinology 2008;149(6):3118-29.
2008: Jemma Evans; Rob D Catalano; Kevin Morgan; Hilary Critchley; Robert P Millar; Henry N Jabbour
Prokineticin 1 signaling and gene regulation in early human pregnancy.
Endocrinology 2008;149(6):2877-87.
2008: Adam J Pawson; Elena Faccenda; Stuart Maudsley; Zhi-Liang Lu; Zvi Naor; Robert P Millar
Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization.
Endocrinology 2008;149(3):1415-22.
2008: Colin D White; Alan James Stewart; Zhi-Liang Lu; Robert P Millar; Kevin Morgan
Antiproliferative effects of GnRH agonists: prospects and problems for cancer therapy.
Neuroendocrinology 2008;88(2):67-79.
2008: Robert P Millar; Adam J Pawson; Kevin Morgan; Emilie F Rissman; Zhi-Liang Lu
Diversity of actions of GnRHs mediated by ligand-induced selective signaling.
Frontiers in neuroendocrinology 2008;29(1):17-35.
2008: Alan James Stewart; Robin Sellar; Donald J Wilson; Robert P Millar; Zhi-Liang Lu
Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor.
Molecular pharmacology 2008;73(1):75-81.
2007: Samantha Gardner; Stuart Maudsley; Robert P Millar; Adam J Pawson
Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):3028-38.
2007: Zhi-Liang Lu; Marla Coetsee; Colin D White; Robert P Millar
Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.
The Journal of biological chemistry 2007;282(24):17921-9.
2007: Stuart Maudsley; Zvi Naor; David Bonfil; Lindsay Davidson; Dimitra Karali; Adam J Pawson; Rachel Larder; Caroline Pope; Nancy Nelson; Robert P Millar; Pamela Brown
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.
Molecular endocrinology (Baltimore, Md.) 2007;21(5):1216-33.
2007: Zvi Naor; Henry N Jabbour; Michal Naidich; Adam J Pawson; Kevin Morgan; Sharon Battersby; Michael R Millar; Pamela Brown; Robert P Millar
Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):524-37.
2007: Rakel López de Maturana; Bronwen Martin; Robert P Millar; Pamela Brown; Lindsay Davidson; Adam J Pawson; Moira R Nicol; J Ian Mason; Perdita E Barran; Zvi Naor; Stuart Maudsley
GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
Neuromolecular medicine 2007;9(3):230-48.
2007: Alan James Stewart; Kevin Morgan; Colin Farquharson; Robert P Millar
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues.
Neuroendocrinology 2007;86(4):243-8.
2007: Sipho Mamputha; Zhi-Liang Lu; Roger W Roeske; Robert P Millar; Arieh A Katz; Colleen A Flanagan
Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):281-92.
2006: Kevin Morgan; Robin Sellar; Adam J Pawson; Zhi-Liang Lu; Robert P Millar
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.
Endocrinology 2006;147(11):5041-51.
2006: Masha Dobkin-Bekman; Michal Naidich; Adam J Pawson; Robert P Millar; Rony Seger; Zvi Naor
Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent.
Molecular and cellular endocrinology 2006;252(1-2):184-90.
2006: Stuart Maudsley; Lindsay Davidson; Adam J Pawson; Sarah H Freestone; Rakel López de Maturana; Axel A Thomson; Robert P Millar
Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5.
Neuroendocrinology 2006;84(5):285-300.
2006: Karen E Ratcliffe; Hamish M Fraser; Robin Sellar; Jean Rivier; Robert P Millar
Bifunctional gonadotropin-releasing hormone antagonist-progesterone analogs with increased efficacy and duration of action.
Endocrinology 2006;147(1):571-9.
2005: Perdita E Barran; Roger W Roeske; Adam J Pawson; Robin Sellar; Michael T Bowers; Kevin Morgan; Zhi-Liang Lu; Motoyuki Tsuda; Takehiro Kusakabe; Robert P Millar
Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity.
The Journal of biological chemistry 2005;280(46):38569-75.
2005: Zhi-Liang Lu; Ryan Gallagher; Robin Sellar; Marla Coetsee; Robert P Millar
Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations.
The Journal of biological chemistry 2005;280(33):29796-803.
2005: Sharon Shacham; Maya N Cheifetz; Mati Fridkin; Adam J Pawson; Robert P Millar; Zvi Naor
Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling.
The Journal of biological chemistry 2005;280(32):28981-8.
2005: Adam J Pawson; Stuart Maudsley; Kevin Morgan; Lindsay Davidson; Zvi Naor; Robert P Millar
Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment.
Endocrinology 2005;146(6):2639-49.
2004: Stuart Maudsley; Lindsay Davidson; Adam J Pawson; Raymond Chan; Rakel López de Maturana; Robert P Millar
Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor.
Cancer research 2004;64(20):7533-44.
2004: Katharina Ronacher; Nosisa Matsiliza; Nonhlanhla Nkwanyana; Adam J Pawson; Tasneem Adam; Colleen A Flanagan; Robert P Millar; Arieh A Katz
Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for beta-arrestin-independent internalization.
Endocrinology 2004;145(10):4480-8.
2004: Robert P Millar; Adam J Pawson
Outside-in and inside-out signaling: the new concept that selectivity of ligand binding at the gonadotropin-releasing hormone receptor is modulated by the intracellular environment.
Endocrinology 2004;145(8):3590-3.
2004: Sharon Battersby; Hilary Critchley; Kevin Morgan; Robert P Millar; Henry N Jabbour
Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.
The Journal of clinical endocrinology and metabolism 2004;89(5):2463-9.
2004: Paula M Gault; Kevin Morgan; Adam J Pawson; Robert P Millar; Gerald A Lincoln
Sheep exhibit novel variations in the organization of the mammalian type II gonadotropin-releasing hormone receptor gene.
Endocrinology 2004;145(5):2362-74.
2004: Bernhard J Fromme; Arieh A Katz; Robert P Millar; Colleen A Flanagan
Pro7.33(303) of the human GnRH receptor regulates selective binding of mammalian GnRH.
Molecular and cellular endocrinology 2004;219(1-2):47-59.
2004: Robert P Millar; Zhi-Liang Lu; Adam J Pawson; Colleen A Flanagan; Kevin Morgan; Stuart Maudsley
Gonadotropin-releasing hormone receptors.
Endocrine reviews 2004;25(2):235-75.
2004: Lindsay Davidson; Adam J Pawson; Rakel López de Maturana; Sarah H Freestone; Perdita E Barran; Robert P Millar; Stuart Maudsley
Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src.
The Journal of biological chemistry 2004;279(12):11906-16.
2004: Lindsay Davidson; Adam J Pawson; Robert P Millar; Stuart Maudsley
Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor.
The Journal of biological chemistry 2004;279(3):1980-93.
2003: Adam J Pawson; Kevin Morgan; Stuart Maudsley; Robert P Millar
Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology.
Reproduction (Cambridge, England) 2003;126(3):271-8.
2003: Adam J Pawson; Stuart Maudsley; John Lopes; Arieh A Katz; Yuh-Man Sun; James S Davidson; Robert P Millar
Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical.
Endocrinology 2003;144(9):3860-71.
2003: Richard E Peter; PD Prasada Rao; Santhosh M Baby; Nicola Illing; Robert P Millar
Differential brain distribution of gonadotropin-releasing hormone receptors in the goldfish.
General and comparative endocrinology 2003;132(3):399-408.
2003: Kevin Morgan; Darrell Conklin; Adam J Pawson; Robin Sellar; Thomas R Ott; Robert P Millar
A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.
Endocrinology 2003;144(2):423-36.
2003: Robert P Millar
GnRH II and type II GnRH receptors.
Trends in endocrinology and metabolism: TEM 2003;14(1):35-43.
2002: Kurt Sales; Arieh A Katz; Robert P Millar; Henry N Jabbour
Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells.
Molecular human reproduction 2002;8(12):1065-70.
2002: Kevin D G Pfleger; Jan Bogerd; Robert P Millar
Conformational constraint of mammalian, chicken, and salmon GnRHs, but not GnRH II, enhances binding at mammalian and nonmammalian receptors: evidence for preconfiguration of GnRH II.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2155-62.
2002: Thomas R Ott; Brigitte E Troskie; Roger W Roeske; Nicola Illing; Colleen A Flanagan; Robert P Millar
Two mutations in extracellular loop 2 of the human GnRH receptor convert an antagonist to an agonist.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1079-88.
2002: Kurt Sales; Arieh A Katz; Bruce Howard; Robbert P Soeters; Robert P Millar; Henry N Jabbour; Roggert P Soeters
Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1.
Cancer research 2002;62(2):424-32.
2001: Bernhard J Fromme; Arieh A Katz; Roger W Roeske; Robert P Millar; Colleen A Flanagan
Role of aspartate7.32(302) of the human gonadotropin-releasing hormone receptor in stabilizing a high-affinity ligand conformation.
Molecular pharmacology 2001;60(6):1280-7.
2001: B Faurholm; Robert P Millar; Arieh A Katz
The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.
Genomics 2001;78(1-2):15-8.
2001: HM Everest; James N Hislop; Tom Harding; James B Uney; A Flynn; Robert P Millar; Craig A McArdle
Signaling and antiproliferative effects mediated by GnRH receptors after expression in breast cancer cells using recombinant adenovirus.
Endocrinology 2001;142(11):4663-72.
2001: James N Hislop; HM Everest; A Flynn; Tom Harding; James B Uney; Brigitte E Troskie; Robert P Millar; Craig A McArdle
Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling.
The Journal of biological chemistry 2001;276(43):39685-94.
2001: Kurt Sales; Arieh A Katz; M Davis; S Hinz; Roggert P Soeters; M D Hofmeyr; Robert P Millar; Henry N Jabbour
Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors.
The Journal of clinical endocrinology and metabolism 2001;86(5):2243-9.
2001: Rex Robison; Richard B White; Nicola Illing; Brigitte E Troskie; M Morley; Robert P Millar; Russell D Fernald
Gonadotropin-releasing hormone receptor in the teleost Haplochromis burtoni: structure, location, and function.
Endocrinology 2001;142(5):1737-43.
2001: Yuh-Man Sun; Colleen A Flanagan; Nicola Illing; Thomas R Ott; Robin Sellar; Bernhard J Fromme; JP Hapgood; P Sharp; Stuart C Sealfon; Robert P Millar
A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants.
The Journal of biological chemistry 2001;276(11):7754-61.
2001: Li Wang; Jan Bogerd; Hueng-Sik Choi; Jae Young Seong; Jae Mok Soh; Sang-Young Chun; Marion Blomenröhr; Brigitte E Troskie; Robert P Millar; W H Yu; S M McCann; Hyuk Bang Kwon
Three distinct types of GnRH receptor characterized in the bullfrog.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):361-6.
2001: Yuh-Man Sun; Ian C Dunn; E Baines; RT Talbot; Nicola Illing; Robert P Millar; Peter J Sharp
Distribution and regulation by oestrogen of fully processed and variant transcripts of gonadotropin releasing hormone I and gonadotropin releasing hormone receptor mRNAs in the male chicken.
Journal of neuroendocrinology 2001;13(1):37-49.
2000: James N Hislop; M T Madziva; HM Everest; Tom Harding; James B Uney; Gary B Willars; Robert P Millar; Brigitte E Troskie; James S Davidson; Craig A McArdle
Desensitization and internalization of human and xenopus gonadotropin-releasing hormone receptors expressed in alphaT4 pituitary cells using recombinant adenovirus.
Endocrinology 2000;141(12):4564-75.
2000: Colleen A Flanagan; V Rodic; K Konvicka; Tony Yuen; L Chi; J E Rivier; Robert P Millar; HAREL WEINSTEIN; Stuart C Sealfon
Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction.
Biochemistry 2000;39(28):8133-41.
2000: MS Yoo; Hae Mook Kang; Hueng-Sik Choi; Jung Woo Kim; Brigitte E Troskie; Robert P Millar; Hyuk Bang Kwon
Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone ([Trp8] GnRH) in frog brain.
Molecular and cellular endocrinology 2000;164(1-2):197-204.
2000: Brigitte E Troskie; JP Hapgood; Robert P Millar; Nicola Illing
Complementary deoxyribonucleic acid cloning, gene expression, and ligand selectivity of a novel gonadotropin-releasing hormone receptor expressed in the pituitary and midbrain of Xenopus laevis.
Endocrinology 2000;141(5):1764-71.
2000: J A King; A Fidler; S Lawrence; Tasneem Adam; Robert P Millar; A Katz
Cloning and expression, pharmacological characterization, and internalization kinetics of the pituitary GnRH receptor in a metatherian species of mammal.
General and comparative endocrinology 2000;117(3):439-48.
1999: D Assefa; Adam J Pawson; Craig A McArdle; Robert P Millar; Colleen A Flanagan; Roger W Roeske; James S Davidson
A new photoreactive antagonist cross-links to the N-terminal domain of the gonadotropin-releasing hormone receptor.
Molecular and cellular endocrinology 1999;156(1-2):179-88.
1999: Colleen A Flanagan; W Zhou; L Chi; Tony Yuen; V Rodic; D Robertson; M Johnson; P Holland; Robert P Millar; HAREL WEINSTEIN; R Mitchell; Stuart C Sealfon
The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor.
The Journal of biological chemistry 1999;274(41):28880-6.
1999: Nicola Illing; Brigitte E Troskie; C S Nahorniak; JP Hapgood; Richard E Peter; Robert P Millar
Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2526-31.
1998: Michael Alexander cowley; A Rao; P J Wright; Nicola Illing; Robert P Millar; Iain J Clarke
Evidence for differential regulation of multiple transcripts of the gonadotropin releasing hormone receptor in the ovine pituitary gland; effect of estrogen.
Molecular and cellular endocrinology 1998;146(1-2):141-9.
1998: D B Myburgh; Adam J Pawson; James S Davidson; Colleen A Flanagan; Robert P Millar; JP Hapgood
A single amino acid substitution in transmembrane helix VI results in overexpression of the human GnRH receptor.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(4):438-47.
1998: Colleen A Flanagan; Bernhard J Fromme; James S Davidson; Robert P Millar
A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors.
Endocrinology 1998;139(10):4115-9.
1998: Yuh-Man Sun; Robert P Millar; H Ho; Marvin C Gershengorn; Nicola Illing
Cloning and characterization of the chicken thyrotropin-releasing hormone receptor.
Endocrinology 1998;139(8):3390-8.
1998: D B Myburgh; Robert P Millar; JP Hapgood
Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization.
The Biochemical journal 1998;331 ( Pt 3)():893-6.
1998: Juan A Ballesteros; S Kitanovic; Frank Guarnieri; P Davies; Bernhard J Fromme; K Konvicka; L Chi; Robert P Millar; James S Davidson; HAREL WEINSTEIN; Stuart C Sealfon
Functional microdomains in G-protein-coupled receptors. The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor.
The Journal of biological chemistry 1998;273(17):10445-53.
1998: Iain J Clarke; B W Brown; V V Tran; Christopher J Scott; R Fry; Robert P Millar; Alexandra Rao
Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood.
Endocrinology 1998;139(4):2007-14.
1998: Adam J Pawson; A Katz; Yuh-Man Sun; J Lopes; Nicola Illing; Robert P Millar; James S Davidson
Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail.
The Journal of endocrinology 1998;156(3):R9-12.
1997: P V Kaye; JP Hapgood; Robert P Millar
Absence of mutations in exon 3 of the GnRH receptor in human gonadotroph adenomas.
Clinical endocrinology 1997;47(5):549-54.
1997: Brigitte E Troskie; J A King; Robert P Millar; Y Y Peng; J Kim; H Figueras; Nicola Illing
Chicken GnRH II-like peptides and a GnRH receptor selective for chicken GnRH II in amphibian sympathetic ganglia.
Neuroendocrinology 1997;65(6):396-402.
1997: Colleen A Flanagan; Robert P Millar; Nicola Illing
Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions.
Reviews of reproduction 1997;2(2):113-20.
1997: Stuart C Sealfon; HAREL WEINSTEIN; Robert P Millar
Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor.
Endocrine reviews 1997;18(2):180-205.
1997: Dilys M Parry; Arthur R Goldsmith; Robert P Millar; L M Glennie
Immunocytochemical localization of GnRH precursor in the hypothalamus of European starlings during sexual maturation and photorefractoriness.
Journal of neuroendocrinology 1997;9(3):235-43.
1996: James S Davidson; Craig A McArdle; P Davies; R Elario; Colleen A Flanagan; Robert P Millar
Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide.
The Journal of biological chemistry 1996;271(26):15510-4.
1996: James S Davidson; Colleen A Flanagan; P D Davies; Janet Patricia Hapgood; D Myburgh; R Elario; Robert P Millar; W Forrest-Owen; Craig A McArdle
Incorporation of an additional glycosylation site enhances expression of functional human gonadotropin-releasing hormone receptor.
Endocrine 1996;4(3):207-12.
1996: Colleen A Flanagan; T Tetaz; A I Smith; Robert P Millar
Development of methods for purification of membrane associated gonadotropin-releasing hormone binding proteins.
Biomedical chromatography : BMC 1996;10(2):83-8.
1995: W Zhou; V Rodic; S Kitanovic; Colleen A Flanagan; L Chi; HAREL WEINSTEIN; S Maayani; Robert P Millar; Stuart C Sealfon
A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites.
The Journal of biological chemistry 1995;270(32):18853-7.
1995: J A King; Robert P Millar; M Vallarino; R Pierantoni
Localization and characterization of gonadotropin-releasing hormones in the brain, gonads, and plasma of a dipnoi (lungfish, Protopterus annectens).
Regulatory peptides 1995;57(2):163-74.
1995: Stuart C Sealfon; Robert P Millar
The gonadotrophin-releasing hormone receptor: structural determinants and regulatory control.
Human reproduction update 1995;1(3):216-30.
1995: M Montero; Nadine Le Belle; J A King; Robert P Millar; S Dufour
Differential regulation of the two forms of gonadotropin-releasing hormone (mGnRH and cGnRH-II) by sex steroids in the European female silver eel (Anguilla anguilla).
Neuroendocrinology 1995;61(5):525-35.
1995: G F Jacobs; Colleen A Flanagan; Roger W Roeske; Robert P Millar
Agonist activity of mammalian gonadotropin-releasing antagonists in chicken gonadotropes reflects marked differences in vertebrate gonadotropin-releasing receptors.
Molecular and cellular endocrinology 1995;108(1-2):107-13.
1995: James S Davidson; Colleen A Flanagan; W Zhou; I I Becker; R Elario; W Emeran; Stuart C Sealfon; Robert P Millar
Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding.
Molecular and cellular endocrinology 1995;107(2):241-5.
1995: J A King; Robert P Millar
Evolutionary aspects of gonadotropin-releasing hormone and its receptor.
Cellular and molecular neurobiology 1995;15(1):5-23.
1995: Stuart C Sealfon; Robert P Millar
Functional domains of the gonadotropin-releasing hormone receptor.
Cellular and molecular neurobiology 1995;15(1):25-42.
1994: J A King; A A Steneveld; J D Curlewis; E F Rissman; Robert P Millar
Identification of chicken GnRH II in brains of metatherian and early-evolved eutherian species of mammals.
Regulatory peptides 1994;54(2-3):467-77.
1994: Steven G Soule; J A King; Robert P Millar
Incorporation of D-Ala2 in growth hormone-releasing hormone-(1-29)-NH2 increases the half-life and decreases metabolic clearance in normal men.
The Journal of clinical endocrinology and metabolism 1994;79(4):1208-11.
1994: Colleen A Flanagan; I I Becker; James S Davidson; I K Wakefield; W Zhou; Stuart C Sealfon; Robert P Millar
Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone.
The Journal of biological chemistry 1994;269(36):22636-41.
1994: James S Davidson; I K Wakefield; Robert P Millar
Absence of rapid desensitization of the mouse gonadotropin-releasing hormone receptor.
The Biochemical journal 1994;300 ( Pt 2)():299-302.
1994: James S Davidson; Colleen A Flanagan; I I Becker; Nicola Illing; Stuart C Sealfon; Robert P Millar
Molecular function of the gonadotropin-releasing hormone receptor: insights from site-directed mutagenesis.
Molecular and cellular endocrinology 1994;100(1-2):9-14.
1994: J A King; A A Steneveld; Robert P Millar
Differential regional distribution of gonadotropin-releasing hormones in amphibian (clawed toad, Xenopus laevis) brain.
Regulatory peptides 1994;50(3):277-89.
1994: W Zhou; Colleen A Flanagan; J A Ballesteros; K Konvicka; James S Davidson; HAREL WEINSTEIN; Robert P Millar; Stuart C Sealfon
A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor.
Molecular pharmacology 1994;45(2):165-70.
1993: Nicola Illing; G F Jacobs; I I Becker; Colleen A Flanagan; James S Davidson; A Eales; W Zhou; Stuart C Sealfon; Robert P Millar
Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors.
Biochemical and biophysical research communications 1993;196(2):745-51.
1993: James S Davidson; A Eales; Roger W Roeske; Robert P Millar
Inhibition of pituitary hormone exocytosis by a synthetic peptide related to the rab effector domain.
FEBS letters 1993;326(1-3):219-21.
1993: James S Davidson; S E Franco; Robert P Millar
Stimulation by Mn2+ and inhibition by Cd2+, Zn2+, Ni2+, and Co2+ ions of luteinizing hormone exocytosis at an intracellular site.
Endocrinology 1993;132(6):2654-8.
1993: L Chi; W Zhou; A Prikhozhan; Colleen A Flanagan; James S Davidson; Myriam Golembo; Nicola Illing; Robert P Millar; Stuart C Sealfon
Cloning and characterization of the human GnRH receptor.
Molecular and cellular endocrinology 1993;91(1-2):R1-6.
1992: James S Davidson; I K Wakefield; Philip van der Merwe; Robert P Millar
Involvement of pertussis toxin-sensitive and -insensitive GTP-binding proteins in luteinizing hormone exocytosis distal to second messenger generation.
Cellular signalling 1992;4(4):379-84.
1992: M Tsutsumi; W Zhou; Robert P Millar; Pamela L Mellon; James Roberts; Colleen A Flanagan; Ke-Wen Dong; B Gillo; Stuart C Sealfon
Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1163-9.
1992: P V Kaye; Philip van der Merwe; Robert P Millar; James S Davidson
Arachidonic acid-induced LH release is ATP-independent and insensitive to N-ethyl maleimide.
The Journal of endocrinology 1992;132(1):77-82.
1992: J A King; A A Steneveld; Robert P Millar; Silvia Fasano; G Romano; A Spagnuolo; L Zanetti; Riccardo Pierantoni
Gonadotropin-releasing hormone in elasmobranch (electric ray, Torpedo marmorata) brain and plasma: chromatographic and immunological evidence for chicken GnRH II and novel molecular forms.
Peptides 1992;13(1):27-35.
1991: Philip van der Merwe; Robert P Millar; I K Wakefield; James S Davidson
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation.
The Biochemical journal 1991;275 ( Pt 2)():399-405.
1991: J Davidson; Philip van der Merwe; I Wakefield; Robert P Millar
Mechanisms of luteinizing hormone secretion: new insights from studies with permeabilized cells.
Molecular and cellular endocrinology 1991;76(1-3):C33-8.
1990: W H Yu; Robert P Millar; saskia c f milton; Raymond de Lisle Milton; S M McCann
Selective FSH-releasing activity of [D-Trp9]GAP1-13: comparison with gonadotropin-releasing abilities of analogs of GAP and natural LHRHs.
Brain research bulletin 1990;25(6):867-73.
1990: M B Macrae; James S Davidson; Robert P Millar; Philip van der Merwe
Cyclic AMP stimulates luteinizing-hormone (lutropin) exocytosis in permeabilized sheep anterior-pituitary cells. Synergism with protein kinase C and calcium.
The Biochemical journal 1990;271(3):635-9.
1990: Philip van der Merwe; Robert P Millar; I K Wakefield; M B Macrae; James S Davidson
Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion.
FEBS letters 1990;267(1):111-3.
1990: Philip van der Merwe; Robert P Millar; James S Davidson
Calcium stimulates luteinizing-hormone (lutropin) exocytosis by a mechanism independent of protein kinase C.
The Biochemical journal 1990;268(2):493-8.
1990: J A King; L A Hinds; A E Mehl; N R Saunders; Robert P Millar
Chicken GnRH II occurs together with mammalian GnRH in a South American species of marsupial (Monodelphis domestica).
Peptides 1990;11(3):521-5.
1990: J A King; S Dufour; Y A Fontaine; Robert P Millar
Chromatographic and immunological evidence for mammalian GnRH and chicken GnRH II in eel (Anguilla anguilla) brain and pituitary.
Peptides 1990;11(3):507-14.
1990: I A Katz; Robert P Millar; J A King
Differential regional distribution and release of two forms of gonadotropin-releasing hormone in the chicken brain.
Peptides 1990;11(3):443-50.
1990: J A King; Robert P Millar
Genealogy of the GnRH family.
Progress in clinical and biological research 1990;342():54-9.
1990: James S Davidson; I K Wakefield; U Sohnius; Philip van der Merwe; Robert P Millar
A novel extracellular nucleotide receptor coupled to phosphoinositidase-C in pituitary cells.
Endocrinology 1990;126(1):80-7.
1989: Robert P Millar; Colleen A Flanagan; Raymond de Lisle Milton; J A King
Chimeric analogues of vertebrate gonadotropin-releasing hormones comprising substitutions of the variant amino acids in positions 5, 7, and 8. Characterization of requirements for receptor binding and gonadotropin release in mammalian and avian pituitary gonadotropes.
The Journal of biological chemistry 1989;264(35):21007-13.
1989: Philip van der Merwe; Robert P Millar; I K Wakefield; James S Davidson
Mechanisms of luteinizing-hormone exocytosis in Staphylococcus aureus-alpha-toxin-permeabilized sheep gonadotropes.
The Biochemical journal 1989;264(3):901-8.
1989: J A King; A E Mehl; C H Tyndale-Biscoe; L Hinds; Robert P Millar
A second form of gonadotropin-releasing hormone (GnRH), with chicken GnRH II-like properties, occurs together with mammalian GnRH in marsupial brains.
Endocrinology 1989;125(5):2244-52.
1989: W H Yu; M Arisawa; Robert P Millar; S M McCann
Effects of the gonadotropin-releasing hormone associated peptides (GAP) on the release of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) in vivo.
Peptides 1989;10(6):1133-8.
1989: P J Wormald; Robert P Millar; B Kerdelhué
Substance P receptors in human pituitary: a potential inhibitor of luteinizing hormone secretion.
The Journal of clinical endocrinology and metabolism 1989;69(3):612-5.
1989: C E Smith; James S Davidson; Robert P Millar
Ba2+ stimulation of luteinizing-hormone release demonstrates two mechanisms of Ca2+ entry in gonadotrope cells.
The Biochemical journal 1989;259(1):217-21.
1989: J A King; James S Davidson; A E Mehl; I K Wakefield; P B Andersson; Robert P Millar
Gonadal steroid modulation of signal transduction and luteinizing hormone release in cultured chicken pituitary cells.
Endocrinology 1989;124(4):1830-40.
1989: P J Wormald; M J Abrahamson; P H Seeburg; K Nikolics; Robert P Millar
Prolactin-inhibiting activity of GnRH associated peptide in cultured human pituitary cells.
Clinical endocrinology 1989;30(2):149-55.
1989: Philip van der Merwe; I K Wakefield; J Fine; Robert P Millar; James S Davidson
Extracellular adenosine triphosphate activates phospholipase C and mobilizes intracellular calcium in primary cultures of sheep anterior pituitary cells.
FEBS letters 1989;243(2):333-6.
1988: P J Wormald; M J Abrahamson; Robert P Millar
Culture of functionally active human pituitary cells: investigation of gonadotropin regulation.
The Journal of clinical endocrinology and metabolism 1988;66(6):1272-7.
1988: J A King; M F Hassan; A E Mehl; Robert P Millar
Gonadotropin-releasing hormone molecular forms in mammalian hypothalamus.
Endocrinology 1988;122(6):2742-52.
1988: J A King; James S Davidson; Robert P Millar
Interaction of endogenous chicken gonadotrophin-releasing hormone-I and -II on chicken pituitary cells.
The Journal of endocrinology 1988;117(1):43-9.
1988: James S Davidson; I K Wakefield; J A King; G P Mulligan; Robert P Millar
Dual pathways of calcium entry in spike and plateau phases of luteinizing hormone release from chicken pituitary cells: sequential activation of receptor-operated and voltage-sensitive calcium channels by gonadotropin-releasing hormone.
Molecular endocrinology (Baltimore, Md.) 1988;2(4):382-90.
1987: C E Smith; I Wakefield; J A King; Z Naor; Robert P Millar; James S Davidson
The initial phase of GnRH-stimulated LH release from pituitary cells is independent of calcium entry through voltage-gated channels.
FEBS letters 1987;225(1-2):247-50.
1987: Robert P Millar; J A King; James S Davidson; R C Milton
Gonadotrophin-releasing hormone--diversity of functions and clinical applications.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1987;72(11):748-55.
1987: M J Abrahamson; P J Wormald; Robert P Millar
Neuroendocrine regulation of thyrotropin release in cultured human pituitary cells.
The Journal of clinical endocrinology and metabolism 1987;65(6):1159-63.
1987: James S Davidson; I Wakefield; J A King; Robert P Millar
Barium-induced LH release from chicken pituitary cells: synergism with phorbol ester.
The Journal of endocrinology 1987;114(1):11-6.
1987: saskia c f milton; Robert P Millar; R C Milton
LH-releasing activity and receptor binding of pHGnRH 14-26 analogues.
Biochemical and biophysical research communications 1987;143(3):872-9.