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Keith Miller

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Rooma Desai; Keith W Miller; Douglas Raines
The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.
Sivananthaperumal Shanmugasundararaj; Thilo Stehle; Dan Wang; Xiaojuan Zhou; Karol S Bruzik; Joydip Das; Robert O Messing; Warren S Sandberg; Keith W Miller
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*.
Pavel Y Savechenkov; Deirdre S Stewart; Xi Zhang; Xiaojuan Zhou; David C Chiara; Jonathan B Cohen; Stuart A Forman; Rile Ge; Keith W Miller; Douglas Raines; Karol S Bruzik
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

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All Publications

2013: Rooma Desai; Keith W Miller; Douglas Raines
The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.
Anesthesia and analgesia 2013;116(3):573-9.
2012: Sivananthaperumal Shanmugasundararaj; Thilo Stehle; Dan Wang; Xiaojuan Zhou; Karol S Bruzik; Joydip Das; Robert O Messing; Warren S Sandberg; Keith W Miller
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*.
Biophysical journal 2012;103(11):2331-40.
2012: Pavel Y Savechenkov; Deirdre S Stewart; Xi Zhang; Xiaojuan Zhou; David C Chiara; Jonathan B Cohen; Stuart A Forman; Rile Ge; Keith W Miller; Douglas Raines; Karol S Bruzik
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
Journal of medicinal chemistry 2012;55(14):6554-65.
2012: David C Chiara; Zuzana Dostalova; Selwyn S Jayakar; Keith W Miller; Xiaojuan Zhou; Jonathan B Cohen
Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.
Biochemistry 2012;51(4):836-47.
2012: Sivananthaperumal Shanmugasundararaj; Claire Tseng; Herve I Yamodo; Khanh Nguyen; George H Addona; S Shaukat Husain; Simon Lehle; Keith W Miller
The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.
PloS one 2012;7(1):e29854.
2011: Deirdre S Stewart; Douglas Raines; Pavel Yuryevich Savechenkov; Karol S Bruzik; David C Chiara; Jonathan B Cohen; Zuzana Dostalova; Stuart A Forman; Rile Ge; Keith W Miller
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
Journal of medicinal chemistry 2011;54(23):8124-35.
2011: Stuart A Forman; Keith W Miller
Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2011;58(2):191-205.
2010: S Shaukat Husain; Deirdre Stewart; Rooma Desai; Ayman K Hamouda; S Guo-Dong Li; Elizabeth Kelly; Zuzana Dostalova; Xiaojuan Zhou; Joseph F Cotten; Douglas Raines; Richard W Olsen; jonathan cohen; Stuart A Forman; Keith W Miller
p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
Journal of medicinal chemistry 2010;53(17):6432-44.
2010: Zuzana Dostalova; Aiping Liu; Xiaojuan Zhou; Sarah L Farmer; Eileen S Krenzel; Enrique Arevalo; Rooma Desai; Paula L Feinberg-Zadek; Paul A Davies; Innocent H Yamodo; Stuart A Forman; Keith W Miller
High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.
Protein science : a publication of the Protein Society 2010;19(9):1728-38.
2010: Joseph F Cotten; Stuart A Forman; Joydev K Laha; Gregory D Cuny; S Shaukat Husain; Keith W Miller; Hieu H Nguyen; Elizabeth W Kelly; Deirdre Stewart; Aiping Liu; Douglas Raines
Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
Anesthesiology 2010;112(3):637-44.
2010: Innocent H Yamodo; David C Chiara; Jonathan B Cohen; Keith W Miller
Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization.
Biochemistry 2010;49(1):156-65.
2009: Joseph F Cotten; S Shaukat Husain; Stuart A Forman; Keith W Miller; Elizabeth W Kelly; Hieu H Nguyen; Douglas Raines
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
Anesthesiology 2009;111(2):240-9.
2009: David C Chiara; Filbert H Hong; Enrique Arevalo; S Shaukat Husain; Keith W Miller; Stuart A Forman; jonathan cohen
Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
Molecular pharmacology 2009;75(5):1084-95.
2008: Enrique Arevalo; Sivananthaperumal Shanmugasundararaj; Michael F Wilkemeyer; Xiaowei Dou; Suzhen Chen; Michael E Charness; Keith W Miller
An alcohol binding site on the neural cell adhesion molecule L1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):371-5.
2007: Philip Williamson; Aswin Verhoeven; Keith W Miller; Beat H Meier; Anthony Watts
The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18031-6.
2007: Azad Kumar; Navneet K Tyagi; Enrique Arevalo; Keith W Miller; Rolf Kinne
A proteomic study of sodium/D-glucose cotransporter 1 (SGLT1): topology of loop 13 and coverage of other functionally important domains.
Biochimica et biophysica acta 2007;1774(8):968-74.
2006: Joydip Das; Xiaojuan Zhou; Keith W Miller
Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta.
Protein science : a publication of the Protein Society 2006;15(9):2107-19.
2006: S Shaukat Husain; Selvanayagam Nirthanan; Dirk Ruesch; Ken Solt; Qi Cheng; Guo-Dong Li; Enrique Arevalo; Richard W Olsen; Douglas Raines; Stuart A Forman; jonathan cohen; Keith W Miller
Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.
Journal of medicinal chemistry 2006;49(16):4818-25.
2005: Mark Liao; James M Sonner; S Shaukat Husain; Keith W Miller; Rachel Jurd; Uwe Rudolph; Edmond I Eger
R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit.
Anesthesia and analgesia 2005;101(1):131-5, table of contents.
2005: Enrique Arevalo; David C Chiara; Stuart A Forman; jonathan cohen; Keith W Miller
Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study.
The Journal of biological chemistry 2005;280(14):13631-40.
2004: Joydip Das; George H Addona; Warren S Sandberg; S Shaukat Husain; Thilo Stehle; Keith W Miller
Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta.
The Journal of biological chemistry 2004;279(36):37964-72.
2004: Michael R Ziebell; Selvanayagam Nirthanan; S Shaukat Husain; Keith W Miller; jonathan cohen
Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic.
The Journal of biological chemistry 2004;279(17):17640-9.
2003: Jason A Campagna; Keith W Miller; Stuart A Forman
Mechanisms of actions of inhaled anesthetics.
The New England journal of medicine 2003;348(21):2110-24.
2003: S Shaukat Husain; Michael R Ziebell; Dirk Ruesch; Filbert Hong; Enrique Arevalo; Jonathan A Kosterlitz; Richard W Olsen; Stuart A Forman; jonathan cohen; Keith W Miller
2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.
Journal of medicinal chemistry 2003;46(7):1257-65.
2003: George H Addona; Heinrich Sandermann; Marek A Kloczewiak; Keith W Miller
Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site.
Biochimica et biophysica acta 2003;1609(2):177-82.
2002: George H Addona; S Shaukat Husain; Thilo Stehle; Keith W Miller
Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase.
The Journal of biological chemistry 2002;277(28):25685-91.
2002: Keith W Miller
The nature of sites of general anaesthetic action.
British journal of anaesthesia 2002;89(1):17-31.
2001: Philip Williamson; Jude A Watts; George H Addona; Keith W Miller; Anthony Watts
Dynamics and orientation of N+(CD3)3-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2346-51.
2001: David C Chiara; Marek A Kloczewiak; George H Addona; J A Yu; jonathan cohen; Keith W Miller
Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor.
Biochemistry 2001;40(1):296-304.
2000: MB Pratt; S Shaukat Husain; Keith W Miller; jonathan cohen
Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic.
The Journal of biological chemistry 2000;275(38):29441-51.
1999: S Shaukat Husain; Stuart A Forman; Marek A Kloczewiak; George H Addona; Richard W Olsen; MB Pratt; jonathan cohen; Keith W Miller
Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic.
Journal of medicinal chemistry 1999;42(17):3300-7.
1999: George H Addona; Marek A Kloczewiak; Keith W Miller
Time-resolved photolabeling of membrane proteins: application to the nicotinic acetylcholine receptor.
Analytical biochemistry 1999;267(1):135-40.
1998: Keith W Miller; George H Addona; Marek A Kloczewiak
Approaches to proving there are general anesthetic sites on ligand gated ion channels.
Toxicology letters 1998;100-101():139-47.
1998: Philip Williamson; J Watts; Gerhard Gröbner; Keith W Miller; Anthony Watts
Solid state NMR studies of ligands bound to the nicotinic acetylcholine receptor.
Biochemical Society transactions 1998;26(3):S297.
1998: Philip Williamson; Gerhard Gröbner; Paul J R Spooner; Keith W Miller; Anthony Watts
Probing the agonist binding pocket in the nicotinic acetylcholine receptor: a high-resolution solid-state NMR approach.
Biochemistry 1998;37(30):10854-9.
1998: George H Addona; Heinrich Sandermann; Marek A Kloczewiak; S Shaukat Husain; Keith W Miller
Where does cholesterol act during activation of the nicotinic acetylcholine receptor?
Biochimica et biophysica acta 1998;1370(2):299-309.
1997: S E Rankin; George H Addona; Marek A Kloczewiak; B Bugge; Keith W Miller
The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor.
Biophysical journal 1997;73(5):2446-55.
1997: Heinrich Sandermann; George H Addona; Keith W Miller
A thermodynamic analysis of the partitioning of cholesterol and related compounds between trioleoylglycerol and egg phosphatidylcholine bilayers.
Biochimica et biophysica acta 1997;1346(2):158-62.
1997: C J Wilson; S Shaukat Husain; Evelyn R Stimson; Lawrence J Dangott; Keith W Miller; John E Maggio
p-(4-Hydroxybenzoyl)phenylalanine: a photoreactive amino acid analog amenable to radioiodination for elucidation of peptide-protein interaction. Application to substance P receptor.
Biochemistry 1997;36(15):4542-51.
1995: S A Forman; Keith W Miller; Gary Yellen
A discrete site for general anesthetics on a postsynaptic receptor.
Molecular pharmacology 1995;48(4):574-81.
1995: Douglas Raines; G Wu; L A Dalton; Keith W Miller
Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes.
Biophysical journal 1995;69(2):498-505.
1995: Douglas Raines; S E Rankin; Keith W Miller
General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations.
Anesthesiology 1995;82(1):276-87; discussion 31A-32A.
1995: Peter Tonner; Keith W Miller
Molecular sites of general anaesthetic action on acetylcholine receptors.
European journal of anaesthesiology 1995;12(1):21-30.
1995: S C Wood; Peter Tonner; A J de Armendi; B Bugge; Keith W Miller
Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor.
Molecular pharmacology 1995;47(1):121-30.
1994: G Wu; Douglas Raines; Keith W Miller
A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state.
Biochemistry 1994;33(51):15375-81.
1994: L L Firestone; J K Alifimoff; Keith W Miller
Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering?
Molecular pharmacology 1994;46(3):508-15.
1994: V Abadji; Douglas Raines; L A Dalton; Keith W Miller
Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol.
Biochimica et biophysica acta 1994;1194(1):25-34.
1994: G Wu; Keith W Miller
Ethanol enhances agonist-induced fast desensitization in nicotinic acetylcholine receptors.
Biochemistry 1994;33(31):9085-91.
1994: G Wu; Peter Tonner; Keith W Miller
Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor.
Molecular pharmacology 1994;45(1):102-8.
1993: S C Wood; W A Hill; Keith W Miller
Cycloalkanemethanols discriminate between volume- and length-dependent loss of activity of alkanols at the Torpedo nicotinic acetylcholine receptor.
Molecular pharmacology 1993;44(6):1219-26.
1993: A J de Armendi; Peter Tonner; B Bugge; Keith W Miller
Barbiturate action is dependent on the conformational state of the acetylcholine receptor.
Anesthesiology 1993;79(5):1033-41.
1993: L A Dalton; Keith W Miller
Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol.
Biophysical journal 1993;65(4):1620-31.
1993: J K Alifimoff; B Bugge; S A Forman; Keith W Miller
Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors.
Anesthesiology 1993;79(1):122-8.
1993: John E Baenziger; Keith W Miller; Kenneth Rothschild
Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization.
Biochemistry 1993;32(20):5448-54.
1993: Douglas Raines; S E Korten; A G Hill; Keith W Miller
Anesthetic cutoff in cycloalkanemethanols. A test of current theories.
Anesthesiology 1993;78(5):918-27.
1993: V C Abadji; Douglas Raines; Anthony Watts; Keith W Miller
The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.
Biochimica et biophysica acta 1993;1147(1):143-53.
1993: Douglas Raines; Keith W Miller
The role of charge in lipid selectivity for the nicotinic acetylcholine receptor.
Biophysical journal 1993;64(3):632-41.
1992: Peter Tonner; D M Poppers; Keith W Miller
The general anesthetic potency of propofol and its dependence on hydrostatic pressure.
Anesthesiology 1992;77(5):926-31.
1992: Peter Tonner; S C Wood; Keith W Miller
Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo?
Molecular pharmacology 1992;42(5):890-7.
1992: John E Baenziger; Keith W Miller; Michael McCarthy; Kenneth Rothschild
Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy.
Biophysical journal 1992;62(1):64-6.
1992: John E Baenziger; Keith W Miller; Kenneth Rothschild
Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and Fourier transform infrared difference spectroscopy.
Biophysical journal 1992;61(4):983-92.
1991: S C Wood; S A Forman; Keith W Miller
Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.
Molecular pharmacology 1991;39(3):332-8.
1991: Keith W Miller; S C Wood; S A Forman; B Bugge; W A Hill; V Abadji
The nicotinic acetylcholine receptor in its membrane environment.
Annals of the New York Academy of Sciences 1991;625():600-15.
1990: B A Dodson; R R Urh; Keith W Miller
Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor.
British journal of pharmacology 1990;101(3):710-4.
1990: D M Fraser; S R Louro; L I Horváath; Keith W Miller; Anthony Watts
A study of the effect of general anesthetics on lipid-protein interactions in acetylcholine receptor enriched membranes from Torpedo nobiliana using nitroxide spin-labels.
Biochemistry 1990;29(11):2664-9.
1989: S H Roth; S A Forman; L M Braswell; Keith W Miller
Actions of pentobarbital enantiomers on nicotinic cholinergic receptors.
Molecular pharmacology 1989;36(6):874-80.
1989: Keith W Miller; L L Firestone; J K Alifimoff; P Streicher
Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):1084-7.
1989: J K Alifimoff; L L Firestone; Keith W Miller
Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site.
British journal of pharmacology 1989;96(1):9-16.
1987: J K Alifimoff; L L Firestone; Keith W Miller
Anesthetic potencies of secondary alcohol enantiomers.
Anesthesiology 1987;66(1):55-9.