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Samuel Miller

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Julien R C Bergeron; Frank Dimaio; Heather B Felise; Samuel I Miller; Richard A Pfuetzner; Nikolaos G Sgourakis; Marija Vuckovic; Liam J Worrall; Angel C Yu; David Baker; Natalie C J Strynadka
A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Ingrid Swanson Pultz; Matthias Christen; Andrew Kennard; Bridget R Kulasekara; Hemantha D Kulasekara; Samuel I Miller
The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP.
Dennis C Ko; Joshua M Akey; Mitchell Brittnacher; M Eileen Dolan; Christine Fong; Eric Gamazon; Tarah D Holden; Cassandra Ogohara; Richard A Pfuetzner; Matthew Radey; Kajal P Shukla; Amy L Stark; Dale Whittington; Mark M Wurfel; Samuel I Miller
Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.

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2013: Julien R C Bergeron; Frank Dimaio; Heather B Felise; Samuel I Miller; Richard A Pfuetzner; Nikolaos G Sgourakis; Marija Vuckovic; Liam J Worrall; Angel C Yu; David Baker; Natalie C J Strynadka
A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
PLoS pathogens 2013;9(4):e1003307.
2012: Ingrid Swanson Pultz; Matthias Christen; Andrew Kennard; Bridget R Kulasekara; Hemantha D Kulasekara; Samuel I Miller
The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP.
Molecular microbiology 2012;86(6):1424-40.
2012: Dennis C Ko; Joshua M Akey; Mitchell Brittnacher; M Eileen Dolan; Christine Fong; Eric Gamazon; Tarah D Holden; Cassandra Ogohara; Richard A Pfuetzner; Matthew Radey; Kajal P Shukla; Amy L Stark; Dale Whittington; Mark M Wurfel; Samuel I Miller
Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):E2343-52.
2012: Doris L LaRock; Itay Levin; Marie-Pierre Blanc; Peter S Brzovic; Samuel I Miller
A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions.
The Journal of biological chemistry 2012;287(35):29654-63.
2012: Toni Kline; Heather B Felise; Sarah Sanowar; Samuel I Miller
The type III secretion system as a source of novel antibacterial drug targets.
Current drug targets 2012;13(3):338-51.
2012: Justin L Spinner; Carleen M Collins; Clayton O Jarrett; Doris L LaRock; Samuel I Miller; B Joseph Hinnebusch
Yersinia pestis insecticidal-like toxin complex (Tc) family proteins: characterization of expression, subcellular localization, and potential role in infection of the flea vector.
BMC microbiology 2012;12():296.
2012: Didier Hocquet; Hemantha D Kulasekara; Catherine Llanes; Didier Mazel; Patrick Plésiat; Michelle Thouverez; Xavier Bertrand; Samuel I Miller
Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.
PLoS pathogens 2012;8(6):e1002778.
2012: Hillary S Hayden; Mitchell Brittnacher; Jean Chang; Eva Crist; Christine Fong; Will Gillett; Eric Haugen; Rajinder Kaul; Regina Lim; Colin Manoil; Samuel I Miller; Sharon J Peacock; Matthew Radey; Elizabeth R Ramage; Laurence Rohmer; Elizabeth H Sims; Zaining Wu; Vanaporn Wuthiekanun; Yang Zhou; Michael A Jacobs
Evolution of Burkholderia pseudomallei in recurrent melioidosis.
PloS one 2012;7(5):e36507.
2011: Amanda K Miller; Samuel I Miller; Mark K Brannon; Niels Høiby; Helle Krogh Johansen; Sara E Selgrade; Laurel Stevens; Samuel M Moskowitz
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients.
Antimicrobial agents and chemotherapy 2011;55(12):5761-9.
2011: Erez Mills; Ingrid S Pultz; Hemantha D Kulasekara; Samuel I Miller
The bacterial second messenger c-di-GMP: mechanisms of signalling.
Cellular microbiology 2011;13(8):1122-9.
2011: Laurence Rohmer; Didier Hocquet; Samuel I Miller
Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis.
Trends in microbiology 2011;19(7):341-8.
2010: Carol Farris; Sarah Sanowar; Martin W Bader; Richard Pfuetzner; Samuel I Miller
Antimicrobial peptides activate the Rcs regulon through the outer membrane lipoprotein RcsF.
Journal of bacteriology 2010;192(19):4894-903.
2010: Matthias Christen; Hemantha D Kulasekara; Beat Christen; Bridget R Kulasekara; Lucas R Hoffman; Samuel I Miller
Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division.
Science (New York, N.Y.) 2010;328(5983):1295-7.
2010: Itay Levin; Catherine M. Eakin; Marie-Pierre Blanc; Rachel E Klevit; Samuel I Miller; Peter S Brzovic
Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):2848-53.
2010: Christine Fong; Dennis C Ko; Michael Wasnick; Matthew Radey; Samuel I Miller; Mitchell Brittnacher
GWAS analyzer: integrating genotype, phenotype and public annotation data for genome-wide association study analysis.
Bioinformatics (Oxford, England) 2010;26(4):560-4.
2010: Sarah Sanowar; Pragya Singh; Richard A Pfuetzner; Ingemar André; Hongjin Zheng; Thomas Spreter; Natalie C J Strynadka; Tamir Gonen; David Baker; David R Goodlett; Samuel I Miller
Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system.
mBio 2010;1(3):.
2010: Heather B Felise; Samuel I Miller
Prospects for the development and use of gram-negative bacterial virulence protein secretion inhibitors for prophylaxis and treatment of infectious diseases.
Critical reviews in immunology 2010;30(1):69-77.
2010: Lucas R Hoffman; Anthony Richardson; Laura S Houston; Hemantha D Kulasekara; Willm Martens-Habbena; Mikkel Klausen; Jane L Burns; David A Stahl; Daniel J Hassett; Ferric C Fang; Samuel I Miller
Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway.
PLoS pathogens 2010;6(1):e1000712.
2009: Bridget R Kulasekara; Michael Jacobs; Yang Zhou; Zaining Wu; Elizabeth Sims; Channakhone Saenphimmachak; Laurence Rohmer; Jennifer M Ritchie; Matthew Radey; Matthew McKevitt; Theodore Larson Freeman; Hillary Hayden; Eric Haugen; Will Gillett; Christine Fong; Jean Chang; Viktoriya Beskhlebnaya; Matthew K Waldor; Mansour Samadpour; Thomas S Whittam; Rajinder Kaul; Mitchell Brittnacher; Samuel I Miller
Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence.
Infection and immunity 2009;77(9):3713-21.
2009: Dennis C Ko; Kajal P Shukla; Christine Fong; Michael Wasnick; Mitchell Brittnacher; Mark M Wurfel; Tarah D Holden; Grant E O'Keefe; Brian Van Yserloo; Joshua M Akey; Samuel I Miller
A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease.
American journal of human genetics 2009;85(2):214-27.
2009: Alexandre Panchaud; Alexander Scherl; Scott A Shaffer; Priska D von Haller; Hemantha D Kulasekara; Samuel I Miller; David R Goodlett
Precursor acquisition independent from ion count: how to dive deeper into the proteomics ocean.
Analytical chemistry 2009;81(15):6481-8.
2009: Thomas Spreter; Calvin K Yip; Sarah Sanowar; Ingemar André; Tyler G Kimbrough; Marija Vuckovic; Richard A Pfuetzner; Wanyin Deng; Angel C Yu; B Brett Finlay; David Baker; Samuel I Miller; Natalie C J Strynadka
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Nature structural & molecular biology 2009;16(5):468-76.
2009: Toni Kline; Kathleen C Barry; Stona R Jackson; Heather B Felise; Hai V Nguyen; Samuel I Miller
Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system.
Bioorganic & medicinal chemistry letters 2009;19(5):1340-3.
2009: Matthias Christen; Lisette H Coye; Jill S Hontz; Doris L LaRock; Richard A Pfuetzner; Samuel I Miller
Activation of a bacterial virulence protein by the GTPase RhoA.
Science signaling 2009;2(95):ra71.
2008: Toni Kline; Stona R Jackson; Wei Deng; Christophe Verlinde; Samuel I Miller
Design and synthesis of bis-carbamate analogs of cyclic bis-(3'-5')-diguanylic acid (c-di-GMP) and the acyclic dimer PGPG.
Nucleosides, nucleotides & nucleic acids 2008;27(12):1282-300.
2008: Pragya Singh; Scott A Shaffer; Alexander Scherl; Carol Holman; Richard A Pfuetzner; Theodore J Larson Freeman; Samuel I Miller; Patricia Hernandez; Ron D Appel; David R Goodlett
Characterization of protein cross-links via mass spectrometry and an open-modification search strategy.
Analytical chemistry 2008;80(22):8799-806.
2008: Maikke B Ohlson; Zhiwei Huang; Neal M Alto; Marie-Pierre Blanc; Jack E Dixon; Jijie Chai; Samuel I Miller
Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
Cell host & microbe 2008;4(5):434-46.
2008: Andrea Haraga; T Eoin West; Mitchell Brittnacher; Shawn J Skerrett; Samuel I Miller
Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei.
Infection and immunity 2008;76(11):5402-11.
2008: Heather B Felise; Hai V Nguyen; Richard A Pfuetzner; Kathleen C Barry; Stona R Jackson; Marie-Pierre Blanc; Philip A Bronstein; Toni Kline; Samuel I Miller
An inhibitor of gram-negative bacterial virulence protein secretion.
Cell host & microbe 2008;4(4):325-36.
2008: Lynne R Prost; Margaret E Daley; Martin W Bader; Rachel E Klevit; Samuel I Miller
The PhoQ histidine kinases of Salmonella and Pseudomonas spp. are structurally and functionally different: evidence that pH and antimicrobial peptide sensing contribute to mammalian pathogenesis.
Molecular microbiology 2008;69(2):503-19.
2008: Hillary S Hayden; Will Gillett; Channakhone Saenphimmachak; Regina Lim; Yang Zhou; Michael A Jacobs; Jean Chang; Laurence Rohmer; David A D'Argenio; Anthony Palmieri; Ruth Levy; Eric Haugen; Gane K S Wong; Mitchell Brittnacher; Jane L Burns; Samuel I Miller; Maynard V Olson; Rajinder Kaul
Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients.
Genomics 2008;91(6):530-7.
2008: Julie A Wasylnka; Malina A Bakowski; Jason Szeto; Maikke B Ohlson; William S Trimble; Samuel I Miller; John H Brumell
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Infection and immunity 2008;76(6):2722-35.
2008: Raz Zarivach; Wanyin Deng; Marija Vuckovic; Heather B Felise; Hai V Nguyen; Samuel I Miller; B Brett Finlay; Natalie C J Strynadka
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS.
Nature 2008;453(7191):124-7.
2008: Laurence Rohmer; Tina Guina; Jinzhi Chen; Byron Gallis; Greg K Taylor; Scott A Shaffer; Samuel I Miller; Mitchell Brittnacher; David R Goodlett
Determination and comparison of the Francisella tularensis subsp.novicida U112 proteome to other bacterial proteomes.
Journal of proteome research 2008;7(5):2016-24.
2008: Alexander Scherl; Scott A Shaffer; Gregory K Taylor; Hemantha D Kulasekara; Samuel I Miller; David R Goodlett
Genome-specific gas-phase fractionation strategy for improved shotgun proteomic profiling of proteotypic peptides.
Analytical chemistry 2008;80(4):1182-91.
2008: T Kline; M Stephen Trent; Chris Stead; M S Lee; M C Sousa; H B Felise; H V Nguyen; Samuel I Miller
Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance.
Bioorganic & medicinal chemistry letters 2008;18(4):1507-10.
2008: Andrea Haraga; Maikke B Ohlson; Samuel I Miller
Salmonellae interplay with host cells.
Nature reviews. Microbiology 2008;6(1):53-66.
2007: Lynne R Prost; Sarah Sanowar; Samuel I Miller
Salmonella sensing of anti-microbial mechanisms to promote survival within macrophages.
Immunological reviews 2007;219():55-65.
2007: Robert Ernst; Samuel M Moskowitz; Julia Emerson; Gretchen M Kraig; Kristin N Adams; Megan D Harvey; Bonnie W Ramsey; David P Speert; Jane L Burns; Samuel I Miller
Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.
The Journal of infectious diseases 2007;196(7):1088-92.
2007: Takeshi Murata; Will Tseng; Tina Guina; Samuel I Miller; Hiroshi Nikaido
PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.
Journal of bacteriology 2007;189(20):7213-22.
2007: Hemantha D Kulasekara; Samuel I Miller
Threonine phosphorylation times bacterial secretion.
Nature cell biology 2007;9(7):734-6.
2007: Lynne R Prost; Margaret E Daley; Valerie Le Sage; Martin W Bader; Hervé Le Moual; Rachel E Klevit; Samuel I Miller
Activation of the bacterial sensor kinase PhoQ by acidic pH.
Molecular cell 2007;26(2):165-74.
2007: Samuel I Miller; Lucas R Hoffman; Sarah Sanowar
Did bacterial sensing of host environments evolve from sensing within microbial communities?
Cell host & microbe 2007;1(2):85-7.
2007: David A D'Argenio; Manhong Wu; Lucas R Hoffman; Hemantha D Kulasekara; Eric Déziel; Eric E Smith; Hai Nguyen; Robert Ernst; Theodore J Larson Freeman; David H Spencer; Mitchell Brittnacher; Hillary S Hayden; Sara Selgrade; Mikkel Klausen; David R Goodlett; Jane L Burns; Bonnie W Ramsey; Samuel I Miller
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients.
Molecular microbiology 2007;64(2):512-33.
2007: Janus A J Haagensen; Mikkel Klausen; Robert Ernst; Samuel I Miller; Anders Folkesson; Tim Tolker-Nielsen; Søren Molin
Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.
Journal of bacteriology 2007;189(1):28-37.
2006: Lucas R Hoffman; Eric Déziel; David A D'Argenio; François Lépine; Julia Emerson; Sharon McNamara; Ronald L Gibson; Bonnie W Ramsey; Samuel I Miller
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19890-5.
2006: Laurence Rohmer; Mitchell Brittnacher; Kerstin Svensson; Danielle Buckley; Eric Haugen; Yang Zhou; Jean Chang; Ruth Levy; Hillary S Hayden; Mats Forsman; Maynard Olson; Anders Johansson; Rajinder Kaul; Samuel I Miller
Potential source of Francisella tularensis live vaccine strain attenuation determined by genome comparison.
Infection and immunity 2006;74(12):6895-906.
2006: Adeline M Hajjar; Megan D Harvey; Scott A Shaffer; David R Goodlett; Anders Sjöstedt; Helen Edebro; Mats Forsman; Mona Byström; Mark Pelletier; Christopher B Wilson; Samuel I Miller; Shawn J Skerrett; Robert Ernst
Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.
Infection and immunity 2006;74(12):6730-8.
2006: Anthony J Hager; Diana L Bolton; Mark R Pelletier; Mitchell Brittnacher; Larry A Gallagher; Rajinder Kaul; Shawn J Skerrett; Samuel I Miller; Tina Guina
Type IV pili-mediated secretion modulates Francisella virulence.
Molecular microbiology 2006;62(1):227-37.
2006: Lucas R Hoffman; Samuel I Miller
The systems biology of infection in animal models bears fruit.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9377-8.
2006: Brook L Nunn; Scott A Shaffer; Alexander Scherl; Byron Gallis; Manhong Wu; Samuel I Miller; David R Goodlett
Comparison of a Salmonella typhimurium proteome defined by shotgun proteomics directly on an LTQ-FT and by proteome pre-fractionation on an LCQ-DUO.
Briefings in functional genomics & proteomics 2006;5(2):154-68.
2006: Edward A Miao; Celia M Alpuche-Aranda; Monica Dors; April E Clark; Martin W Bader; Samuel I Miller; Alan Aderem
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.
Nature immunology 2006;7(6):569-75.
2006: Eric E Smith; Danielle G Buckley; Zaining Wu; Channakhone Saenphimmachak; Lucas R Hoffman; David A D'Argenio; Samuel I Miller; Bonnie W Ramsey; David P Speert; Samuel M Moskowitz; Jane L Burns; Rajinder Kaul; Maynard V Olson
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8487-92.
2006: Andrea Haraga; Samuel I Miller
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.
Cellular microbiology 2006;8(5):837-46.
2006: Uhn Soo Cho; Martin W Bader; Maria F Amaya; Margaret E Daley; Rachel E Klevit; Samuel I Miller; Wenqing Xu
Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling.
Journal of molecular biology 2006;356(5):1193-206.
2006: Roberto Rebeil; Robert Ernst; Clayton O Jarrett; Kristin N Adams; Samuel I Miller; B Joseph Hinnebusch
Characterization of late acyltransferase genes of Yersinia pestis and their role in temperature-dependent lipid A variation.
Journal of bacteriology 2006;188(4):1381-8.
2006: Robert Ernst; Kristin N Adams; Samuel M Moskowitz; Gretchen M Kraig; Kiyoshi Kawasaki; Chris Stead; M Stephen Trent; Samuel I Miller
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.
Journal of bacteriology 2006;188(1):191-201.
2005: Manhong Wu; Tina Guina; Mitchell Brittnacher; Hai Nguyen; Jimmy Eng; Samuel I Miller
The Pseudomonas aeruginosa proteome during anaerobic growth.
Journal of bacteriology 2005;187(23):8185-90.
2005: Maikke B Ohlson; Kerry Fluhr; Cheryl L Birmingham; John H Brumell; Samuel I Miller
SseJ deacylase activity by Salmonella enterica serovar Typhimurium promotes virulence in mice.
Infection and immunity 2005;73(10):6249-59.
2005: Lucas R Hoffman; David A D'Argenio; Michael J MacCoss; Zhaoying Zhang; Roger A Jones; Samuel I Miller
Aminoglycoside antibiotics induce bacterial biofilm formation.
Nature 2005;436(7054):1171-5.
2005: Martin W Bader; Sarah Sanowar; Margaret E Daley; Anna R Schneider; Uhnsoo Cho; Wenqing Xu; Rachel E Klevit; Hervé Le Moual; Samuel I Miller
Recognition of antimicrobial peptides by a bacterial sensor kinase.
Cell 2005;122(3):461-72.
2005: Calvin K Yip; Tyler G Kimbrough; Heather B Felise; Marija Vuckovic; Nikhil A Thomas; Richard A Pfuetzner; Elizabeth A Frey; B Brett Finlay; Samuel I Miller; Natalie C J Strynadka
Structural characterization of the molecular platform for type III secretion system assembly.
Nature 2005;435(7042):702-7.
2005: Hiroki Tanabe; Tokiyoshi Ayabe; Brian W Bainbridge; Tina Guina; Robert Ernst; Richard P Darveau; Samuel I Miller; Andre J Ouellette
Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.
Infection and immunity 2005;73(4):2312-20.
2005: Kiyoshi Kawasaki; Robert Ernst; Samuel I Miller
Inhibition of Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation by aminoarabinose membrane modification.
Journal of bacteriology 2005;187(7):2448-57.
2005: Cheryl L Birmingham; Xiuju Jiang; Maikke B Ohlson; Samuel I Miller; John H Brumell
Salmonella-induced filament formation is a dynamic phenotype induced by rapidly replicating Salmonella enterica serovar typhimurium in epithelial cells.
Infection and immunity 2005;73(2):1204-8.
2005: Kiyoshi Kawasaki; Robert Ernst; Samuel I Miller
Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium.
Journal of endotoxin research 2005;11(1):57-61.
2005: Christiane Beckmann; Mitchell Brittnacher; Robert Ernst; Nicole Mayer-Hamblett; Samuel I Miller; Jane L Burns
Use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections.
Infection and immunity 2005;73(1):444-52.
2005: Samuel I Miller; Robert Ernst; Martin W Bader
LPS, TLR4 and infectious disease diversity.
Nature reviews. Microbiology 2005;3(1):36-46.
2004: David A D'Argenio; Samuel I Miller
Cyclic di-GMP as a bacterial second messenger.
Microbiology (Reading, England) 2004;150(Pt 8):2497-502.
2004: Shawn J Skerrett; H Denny Liggitt; Adeline M Hajjar; Robert Ernst; Samuel I Miller; Christopher B Wilson
Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin.
American journal of physiology. Lung cellular and molecular physiology 2004;287(1):L143-52.
2004: Roberto Rebeil; Robert Ernst; Brian B Gowen; Samuel I Miller; B Joseph Hinnebusch
Variation in lipid A structure in the pathogenic yersiniae.
Molecular microbiology 2004;52(5):1363-73.
2004: Kiyoshi Kawasaki; Robert Ernst; Samuel I Miller
3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase of Salmonella typhimurium, modulates signaling through Toll-like receptor 4.
The Journal of biological chemistry 2004;279(19):20044-8.
2004: Kiyoshi Kawasaki; Robert Ernst; Samuel I Miller
Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4.
Journal of endotoxin research 2004;10(6):439-44.
2004: Samuel M Moskowitz; Robert Ernst; Samuel I Miller
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A.
Journal of bacteriology 2004;186(2):575-9.
2003: Robert Ernst; David A D'Argenio; Jeffrey K Ichikawa; M Gita Bangera; Sara Selgrade; Jane L Burns; Peter Hiatt; Karen McCoy; Mitchell Brittnacher; Arnold Kas; David H Spencer; Maynard V Olson; Bonnie W Ramsey; Stephen Lory; Samuel I Miller
Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis.
Environmental microbiology 2003;5(12):1341-9.
2003: Samuel I Miller; Martin Bader; Tina Guina
Bacterial vesicle formation as a mechanism of protein transfer to animals.
Cell 2003;115(1):2-3.
2003: Martin W Bader; William Wiley Navarre; Whitney Shiau; Hiroshi Nikaido; Jonathan G Frye; Michael McClelland; Ferric C Fang; Samuel I Miller
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides.
Molecular microbiology 2003;50(1):219-30.
2003: Tina Guina; Manhong Wu; Samuel I Miller; Samuel O Purvine; Eugene C Yi; Jimmy Eng; David R Goodlett; Ruedi Aebersold; Robert Ernst; Kimberly A Lee
Proteomic analysis of Pseudomonas aeruginosa grown under magnesium limitation.
Journal of the American Society for Mass Spectrometry 2003;14(7):742-51.
2003: Andrea Haraga; Samuel I Miller
A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression.
Infection and immunity 2003;71(7):4052-8.
2003: Edward A Miao; Mitchell Brittnacher; Andrea Haraga; Robert L Jeng; Matt D Welch; Samuel I Miller
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Molecular microbiology 2003;48(2):401-15.
2003: Tina Guina; Samuel O Purvine; Eugene C Yi; Jimmy Eng; David R Goodlett; Ruedi Aebersold; Samuel I Miller
Quantitative proteomic analysis indicates increased synthesis of a quinolone by Pseudomonas aeruginosa isolates from cystic fibrosis airways.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2771-6.
2003: Robert Ernst; Adeline M Hajjar; Jeff H Tsai; Samuel M Moskowitz; Christopher B Wilson; Samuel I Miller
Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4.
Journal of endotoxin research 2003;9(6):395-400.
2003: Jeremy A Freeman; Michael E Ohl; Samuel I Miller
The Salmonella enterica serovar typhimurium translocated effectors SseJ and SifB are targeted to the Salmonella-containing vacuole.
Infection and immunity 2003;71(1):418-27.
2002: Adeline M Hajjar; Robert Ernst; Jeff H Tsai; Christopher B Wilson; Samuel I Miller
Human Toll-like receptor 4 recognizes host-specific LPS modifications.
Nature immunology 2002;3(4):354-9.
2002: Edward A Miao; Jeremy A Freeman; Samuel I Miller
Transcription of the SsrAB regulon is repressed by alkaline pH and is independent of PhoPQ and magnesium concentration.
Journal of bacteriology 2002;184(5):1493-7.
2002: Tyler G Kimbrough; Samuel I Miller
Assembly of the type III secretion needle complex of Salmonella typhimurium.
Microbes and infection / Institut Pasteur 2002;4(1):75-82.
2001: Z Zhou; Anthony A Ribeiro; Shanhua Lin; Robert J Cotter; Samuel I Miller; Christian R H Raetz
Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation.
The Journal of biological chemistry 2001;276(46):43111-21.
2001: Robert Ernst; Tina Guina; Samuel I Miller
Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity.
Microbes and infection / Institut Pasteur 2001;3(14-15):1327-34.
2001: Cammie F Lesser; Samuel I Miller
Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection.
The EMBO journal 2001;20(8):1840-9.
2001: M Stephen Trent; W Pabich; Christian R H Raetz; Samuel I Miller
A PhoP/PhoQ-induced Lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium.
The Journal of biological chemistry 2001;276(12):9083-92.
2000: P A Bronstein; Edward A Miao; Samuel I Miller
InvB is a type III secretion chaperone specific for SspA.
Journal of bacteriology 2000;182(23):6638-44.
2000: R E Bishop; Henry S. Gibbons; Tina Guina; M Stephen Trent; Samuel I Miller; Christian R H Raetz
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
The EMBO journal 2000;19(19):5071-80.
2000: Tyler G Kimbrough; Samuel I Miller
Contribution of Salmonella typhimurium type III secretion components to needle complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):11008-13.
2000: CA Scherer; E Cooper; Samuel I Miller
The Salmonella type III secretion translocon protein SspC is inserted into the epithelial cell plasma membrane upon infection.
Molecular microbiology 2000;37(5):1133-45.
2000: Tina Guina; Eugene C Yi; H Wang; Murray Hackett; Samuel I Miller
A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides.
Journal of bacteriology 2000;182(14):4077-86.
2000: Edward A Miao; Samuel I Miller
A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7539-44.
2000: Renée M Tsolis; Garry Adams; M J Hantman; CA Scherer; Tyler G Kimbrough; Robert Kingsley; Thomas A Ficht; Samuel I Miller; Andreas J Baumler
SspA is required for lethal Salmonella enterica serovar Typhimurium infections in calves but is not essential for diarrhea.
Infection and immunity 2000;68(6):3158-63.
2000: Cammie F Lesser; CA Scherer; Samuel I Miller
Rac, ruffle and rho: orchestration of Salmonella invasion.
Trends in microbiology 2000;8(4):151-2.
1999: Renée M Tsolis; SM Townsend; Edward A Miao; Samuel I Miller; Thomas A Ficht; Garry Adams; Andreas J Baumler
Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis.
Infection and immunity 1999;67(12):6385-93.
1999: Robert Ernst; Eugene C Yi; L Guo; Kheng B Lim; Jane L Burns; Murray Hackett; Samuel I Miller
Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.
Science (New York, N.Y.) 1999;286(5444):1561-5.
1999: Edward A Miao; CA Scherer; Renée M Tsolis; Robert Kingsley; Garry Adams; Andreas J Baumler; Samuel I Miller
Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems.
Molecular microbiology 1999;34(4):850-64.
1999: Edward A Miao; Samuel I Miller
Bacteriophages in the evolution of pathogen-host interactions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9452-4.
1999: Jennifer L Rakeman; Samuel I Miller
Salmonella typhimurium recognition of intestinal environments.
Trends in microbiology 1999;7(6):221-3.
1999: Jennifer L Rakeman; H R Bonifield; Samuel I Miller
A HilA-independent pathway to Salmonella typhimurium invasion gene transcription.
Journal of bacteriology 1999;181(10):3096-104.
1999: Robert Ernst; Tina Guina; Samuel I Miller
How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses.
The Journal of infectious diseases 1999;179 Suppl 2():S326-30.
1998: L Guo; Kheng B Lim; C M Poduje; M Daniel; John S Gunn; Murray Hackett; Samuel I Miller
Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.
Cell 1998;95(2):189-98.
1998: John S Gunn; W J Belden; Samuel I Miller
Identification of PhoP-PhoQ activated genes within a duplicated region of the Salmonella typhimurium chromosome.
Microbial pathogenesis 1998;25(2):77-90.
1998: John S Gunn; Kheng B Lim; J Krueger; K Kim; L Guo; Murray Hackett; Samuel I Miller
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance.
Molecular microbiology 1998;27(6):1171-82.
1997: L Guo; Kheng B Lim; John S Gunn; Brian W Bainbridge; Richard P Darveau; Murray Hackett; Samuel I Miller
Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ.
Science (New York, N.Y.) 1997;276(5310):250-3.
1997: CA Scherer; M J Hantman; Samuel I Miller
Salmonella invasion and delivery of protein effectors to mammalian cell cytoplasm.
Trends in microbiology 1997;5(4):127-9.
1996: John S Gunn; Samuel I Miller
PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance.
Journal of bacteriology 1996;178(23):6857-64.
1996: C Johnston; D A Pegues; C J Hueck; A Lee; Samuel I Miller
Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily.
Molecular microbiology 1996;22(4):715-27.
1996: John S Gunn; E L Hohmann; Samuel I Miller
Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.
Journal of bacteriology 1996;178(21):6369-73.
1996: Y K Oh; C Alpuche-Aranda; E Berthiaume; T Jinks; Samuel I Miller; Joel A Swanson
Rapid and complete fusion of macrophage lysosomes with phagosomes containing Salmonella typhimurium.
Infection and immunity 1996;64(9):3877-83.
1996: E L Hohmann; C A Oletta; K P Killeen; Samuel I Miller
phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers.
The Journal of infectious diseases 1996;173(6):1408-14.
1996: E L Hohmann; C A Oletta; Samuel I Miller
Evaluation of a phoP/phoQ-deleted, aroA-deleted live oral Salmonella typhi vaccine strain in human volunteers.
Vaccine 1996;14(1):19-24.
1995: C J Hueck; M J Hantman; V Bajaj; C Johnston; C A Lee; Samuel I Miller
Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins.
Molecular microbiology 1995;18(3):479-90.
1995: C M Alpuche-Aranda; E P Berthiaume; B Mock; Joel A Swanson; Samuel I Miller
Spacious phagosome formation within mouse macrophages correlates with Salmonella serotype pathogenicity and host susceptibility.
Infection and immunity 1995;63(11):4456-62.
1995: John S Gunn; C M Alpuche-Aranda; W P Loomis; W J Belden; Samuel I Miller
Characterization of the Salmonella typhimurium pagC/pagD chromosomal region.
Journal of bacteriology 1995;177(17):5040-7.
1995: D A Pegues; M J Hantman; I Behlau; Samuel I Miller
PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion.
Molecular microbiology 1995;17(1):169-81.
1995: E L Hohmann; C A Oletta; W P Loomis; Samuel I Miller
Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2904-8.
1994: W J Belden; Samuel I Miller
Further characterization of the PhoP regulon: identification of new PhoP-activated virulence loci.
Infection and immunity 1994;62(11):5095-101.
1994: C M Alpuche-Aranda; E L Racoosin; Joel A Swanson; Samuel I Miller
Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes.
The Journal of experimental medicine 1994;179(2):601-8.
1993: I Behlau; Samuel I Miller
A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells.
Journal of bacteriology 1993;175(14):4475-84.
1993: Samuel I Miller; W P Loomis; C Alpuche-Aranda; I Behlau; E Hohmann
The PhoP virulence regulon and live oral Salmonella vaccines.
Vaccine 1993;11(2):122-5.
1992: C M Alpuche Aranda; Joel A Swanson; W P Loomis; Samuel I Miller
Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10079-83.
1992: Virginia L Miller; K B Beer; W P Loomis; J A Olson; Samuel I Miller
An unusual pagC::TnphoA mutation leads to an invasion- and virulence-defective phenotype in Salmonellae.
Infection and immunity 1992;60(9):3763-70.
1991: Samuel I Miller
PhoP/PhoQ: macrophage-specific modulators of Salmonella virulence?
Molecular microbiology 1991;5(9):2073-8.
1991: W S Pulkkinen; Samuel I Miller
A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.
Journal of bacteriology 1991;173(1):86-93.
1990: Samuel I Miller; W S Pulkkinen; Michael Selsted; J J Mekalanos
Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.
Infection and immunity 1990;58(11):3706-10.
1990: Samuel I Miller; J J Mekalanos; W S Pulkkinen
Salmonella vaccines with mutations in the phoP virulence regulon.
Research in microbiology 1990;141(7-8):817-21.
1990: Samuel I Miller; John J Mekalanos
Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.
Journal of bacteriology 1990;172(5):2485-90.
1989: Samuel I Miller; A M Kukral; John J Mekalanos
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):5054-8.
1989: Samuel I Miller; John J Mekalanos
Strategies for the development of vaccines for typhoid fever, shigellosis, and cholera.
Annals of the New York Academy of Sciences 1989;569():145-54.