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Gordon Mills
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40
Bast, Robert
26
Lu, Yiling
20
Lapushin, Ruth
17
Hennessy, Bryan T. J.
14
Yu, Shuangxing
14
Liu, Jinsong
14
Eder, Astrid
14
Fang, Xianjun
13
Fang, Xiang
13
Mao, Muling
13
Gray, Joe
12
Cheng, Kwai Wa
11
Murph, Mandi
11
Lu, Ying
10
Hasegawa, Yutaka
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All Publications
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2009: Byers Lauren Averett; Sen Banibrata; Saigal Babita; Diao Lixia; Wang Jing; Nanjundan Meera; Cascone Tina; Mills Gordon B; Heymach John V; Johnson Faye M
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6852-61.
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2009: Liu Shuying; Murph Mandi; Panupinthu Nattapon; Mills Gordon B
ATX-LPA receptor axis in inflammation and cancer.
Cell cycle (Georgetown, Tex.) 2009;8(22):3695-701.
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2009: Agarwal Roshan; Jurisica Igor; Mills Gordon B; Cheng Kwai Wa
The emerging role of the RAB25 small GTPase in cancer.
Traffic (Copenhagen, Denmark) 2009;10(11):1561-8.
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2009: Woodman Scott E; Trent Jonathan C; Stemke-Hale Katherine; Lazar Alexander J; Pricl Sabrina; Pavan Giovanni M; Fermeglia Maurizio; Gopal Y N Vashisht; Yang Dan; Podoloff Donald A; Ivan Doina; Kim Kevin B; Papadopoulos Nicholas; Hwu Patrick; Mills Gordon B; Davies Michael A
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Molecular cancer therapeutics 2009;8(8):2079-85.
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2009: Mills Gordon B; Jurisica Igor; Yarden Yosef; Norman Jim C
Genomic amplicons target vesicle recycling in breast cancer.
The Journal of clinical investigation 2009;119(8):2123-7.
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2009: Liu Shuying; Umezu-Goto Makiko; Murph Mandi; Lu Yiling; Liu Wenbin; Zhang Fan; Yu Shuangxing; Stephens L Clifton; Cui Xiaojiang; Murrow George; Coombes Kevin; Muller William; Hung Mien-Chie; Perou Charles M; Lee Adrian V; Fang Xianjun; Mills Gordon B
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
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2009: Agarwal Roshan; Gonzalez-Angulo Ana-Maria; Myhre Simen; Carey Mark; Lee Ju-Seog; Overgaard Jens; Alsner Jan; Stemke-Hale Katherine; Lluch Ana; Neve Richard M; Kuo Wen Lin; Sorlie Therese; Sahin Aysegul; Valero Vicente; Keyomarsi Khandan; Gray Joe W; Borresen-Dale Anne-Lise; Mills Gordon B; Hennessy Bryan T
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3654-62.
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2009: Bast Robert C; Hennessy Bryan; Mills Gordon B
The biology of ovarian cancer: new opportunities for translation.
Nature reviews. Cancer 2009;9(6):415-28.
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2009: Hennessy Bryan T; Gonzalez-Angulo Ana-Maria; Stemke-Hale Katherine; Gilcrease Michael Z; Krishnamurthy Savitri; Lee Ju-Seog; Fridlyand Jane; Sahin Aysegul; Agarwal Roshan; Joy Corwin; Liu Wenbin; Stivers David; Baggerly Keith; Carey Mark; Lluch Ana; Monteagudo Carlos; He Xiaping; Weigman Victor; Fan Cheng; Palazzo Juan; Hortobagyi Gabriel N; Nolden Laura K; Wang Nicholas J; Valero Vicente; Gray Joe W; Perou Charles M; Mills Gordon B
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Cancer research 2009;69(10):4116-24.
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2009: Yim Eun-Kyoung; Peng Guang; Dai Hui; Hu Ruozhen; Li Kaiyi; Lu Yiling; Mills Gordon B; Meric-Bernstam Funda; Hennessy Bryan T; Craven Rolf J; Lin Shiaw-Yih
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Cancer cell 2009;15(4):304-14.
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2009: Gonzalez-Angulo Ana M; Stemke-Hale Katherine; Palla Shana L; Carey Mark; Agarwal Roshan; Meric-Berstam Funda; Traina Tiffany A; Hudis Clifford; Hortobagyi Gabriel N; Gerald William L; Mills Gordon B; Hennessy Bryan T
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2472-8.
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2009: Nikolova Dessislava A; Asangani Irfan A; Nelson Laura D; Hughes Dennis P M; Siwak Doris R; Mills Gordon B; Harms Andrea; Buchholz Erika; Pilz Lothar R; Manegold Christian; Allgayer Heike
Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
Cancer research 2009;69(6):2461-70.
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2009: Zinner Ralph G; Barrett Brittany L; Popova Elmira; Damien Paul; Volgin Andrei Y; Gelovani Juri G; Lotan Reuben; Tran Hai T; Pisano Claudio; Mills Gordon B; Mao Li; Hong Waun K; Lippman Scott M; Miller John H
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
Molecular cancer therapeutics 2009;8(3):521-32.
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2009: Tuna Musaffe; Knuutila Sakari; Mills Gordon B
Uniparental disomy in cancer.
Trends in molecular medicine 2009;15(3):120-8.
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2009: Zhang Li; Wei Qingyi; Mao Li; Liu Wenbin; Mills Gordon B; Coombes Kevin
Serial dilution curve: a new method for analysis of reverse phase protein array data.
Bioinformatics (Oxford, England) 2009;25(5):650-4.
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2009: Pamuklar Zehra; Federico Lorenzo; Liu Shuying; Umezu-Goto Makiko; Dong Anping; Panchatcharam Manikandan; Fulerson Zachary; Berdyshev Evgeny; Natarajan Viswanathan; Fang Xianjun; van Meeteren Laurens A; Moolenaar Wouter H; Mills Gordon B; Morris Andrew J; Smyth Susan S
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
The Journal of biological chemistry 2009;284(11):7385-94.
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2009: Hennessy Bryan T; Gonzalez-Angulo Ana Maria; Carey Mark S; Mills Gordon B
A systems approach to analysis of molecular complexity in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):417-9.
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2009: Mirzoeva Olga K; Das Debopriya; Heiser Laura M; Bhattacharya Sanchita; Siwak Doris; Gendelman Rina; Bayani Nora; Wang Nicholas J; Neve Richard M; Guan Yinghui; Hu Zhi; Knight Zachary; Feiler Heidi S; Gascard Philippe; Parvin Bahram; Spellman Paul T; Shokat Kevan M; Wyrobek Andrew J; Bissell Mina J; McCormick Frank; Kuo Wen-Lin; Mills Gordon B; Gray Joe W; Korn W Michael
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Cancer research 2009;69(2):565-72.
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2009: Ihle Nathan T; Lemos Robert; Wipf Peter; Yacoub Adly; Mitchell Clint; Siwak Doris; Mills Gordon B; Dent Paul; Kirkpatrick D Lynn; Powis Garth
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Cancer research 2009;69(1):143-50.
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2009: Kornblau Steven M; Tibes Raoul; Qiu Yi Hua; Chen Wenjing; Kantarjian Hagop M; Andreeff Michael; Coombes Kevin R; Mills Gordon B
Functional proteomic profiling of AML predicts response and survival.
Blood 2009;113(1):154-64.
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2009: Murph Mandi M; Liu Wenbin; Yu Shuangxing; Lu Yiling; Hall Hassan; Hennessy Bryan T; Lahad John; Schaner Marci; Helland Aslaug; Kristensen Gunnar; Børresen-Dale Anne-Lise; Mills Gordon B
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
PloS one 2009;4(5):e5583.
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2008: Yu Shuangxing; Murph Mandi M; Lu Yiling; Liu Shuying; Hall Hassan S; Liu Jinsong; Stephens Clifton; Fang Xianjun; Mills Gordon B
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Journal of the National Cancer Institute 2008;100(22):1630-42.
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2008: Lambert Laura A; Qiao Na; Hunt Kelly K; Lambert Donald H; Mills Gordon B; Meijer Laurent; Keyomarsi Khandan
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
Cancer research 2008;68(19):7966-74.
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2008: Davies M A; Stemke-Hale K; Tellez C; Calderone T L; Deng W; Prieto V G; Lazar A J F; Gershenwald J E; Mills G B
A novel AKT3 mutation in melanoma tumours and cell lines.
British journal of cancer 2008;99(8):1265-8.
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2008: Yokoyama T; Iwado E; Kondo Y; Aoki H; Hayashi Y; Georgescu M M; Sawaya R; Hess K R; Mills G B; Kawamura H; Hashimoto Y; Urata Y; Fujiwara T; Kondo S
Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Gene therapy 2008;15(17):1233-9.
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2008: Murph Mandi M; Nguyen Giang H; Radhakrishna Harish; Mills Gordon B
Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.
Biochimica et biophysica acta 2008;1781(9):547-57.
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2008: Wei Yongkun; Xia Weiya; Zhang Zhihong; Liu Jinsong; Wang Huamin; Adsay Nazmi V; Albarracin Constance; Yu Dihua; Abbruzzese James L; Mills Gordon B; Bast Robert C; Hortobagyi Gabriel N; Hung Mien-Chie
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
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2008: Nanjundan Meera; Cheng Kwai Wa; Zhang Fan; Lahad John; Kuo Wen-Lin; Schmandt Rosemarie; Smith-McCune Karen; Fishman David; Gray Joe W; Mills Gordon B
Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
Molecular oncology 2008;2(2):164-81.
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2008: Stemke-Hale Katherine; Gonzalez-Angulo Ana Maria; Lluch Ana; Neve Richard M; Kuo Wen-Lin; Davies Michael; Carey Mark; Hu Zhi; Guan Yinghui; Sahin Aysegul; Symmans W Fraser; Pusztai Lajos; Nolden Laura K; Horlings Hugo; Berns Katrien; Hung Mien-Chie; van de Vijver Marc J; Valero Vicente; Gray Joe W; Bernards René; Mills Gordon B; Hennessy Bryan T
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
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2008: Grote Tobias; Siwak Doris R; Fritsche Herbert A; Joy Corwin; Mills Gordon B; Simeone Diane; Whitcomb David C; Logsdon Craig D
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer.
Proteomics 2008;8(15):3051-60.
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2008: Hasegawa Yutaka; Murph Mandi; Yu Shuangxing; Tigyi Gabor; Mills Gordon B
Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Molecular oncology 2008;2(1):54-69.
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2008: Muller Melissa; Obeyesekere Mandri; Mills Gordon B; Ram Prahlad T
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1393-403.
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2008: Liu Shuying; Fang Xianjun; Hall Hassan; Yu Shuangxing; Smith Debra; Lu Zhimin; Fang Dexing; Liu Jinsong; Stephens L Clifton; Woodgett James R; Mills Gordon B
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
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2008: Ji Yuan; Lu Yiling; Mills Gordon B
Bayesian models based on test statistics for multiple hypothesis testing problems.
Bioinformatics (Oxford, England) 2008;24(7):943-9.
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2008: Yang Jer-Yen; Zong Cong S; Xia Weiya; Yamaguchi Hirohito; Ding Qingqing; Xie Xiaoming; Lang Jing-Yu; Lai Chien-Chen; Chang Chun-Ju; Huang Wei-Chien; Huang Hsin; Kuo Hsu-Ping; Lee Dung-Fang; Li Long-Yuan; Lien Huang-Chun; Cheng Xiaoyun; Chang King-Jen; Hsiao Chwan-Deng; Tsai Fuu-Jen; Tsai Chang-Hai; Sahin Aysegul A; Muller William J; Mills Gordon B; Yu Dihua; Hortobagyi Gabriel N; Hung Mien-Chie
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Nature cell biology 2008;10(2):138-48.
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2008: Freire Pablo; Vilela Marco; Deus Helena; Kim Yong-Wan; Koul Dimpy; Colman Howard; Aldape Kenneth D; Bogler Oliver; Yung W K Alfred; Coombes Kevin; Mills Gordon B; Vasconcelos Ana T; Almeida Jonas S
Exploratory analysis of the copy number alterations in glioblastoma multiforme.
PloS one 2008;3(12):e4076.
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2008: Stanislaus Romesh; Carey Mark; Deus Helena F; Coombes Kevin; Hennessy Bryan T; Mills Gordon B; Almeida Jonas S
RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays.
BMC bioinformatics 2008;9():555.
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2008: Hennessy Bryan T; Murph Mandi; Nanjundan Meera; Carey Mark; Auersperg Nelly; Almeida Jonas; Coombes Kevin R; Liu Jinsong; Lu Yiling; Gray Joe W; Mills Gordon B
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Advances in experimental medicine and biology 2008;617():23-40.
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2007: Gajewiak Joanna; Tsukahara Ryoko; Tsukahara Tamotsu; Fujiwara Yuko; Yu Shuanxing; Lu Yiling; Murph Mandi; Mills Gordon B; Tigyi Gabor; Prestwich Glenn D
Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
ChemMedChem 2007;2(12):1789-98.
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2007: Xu Z-X; Liang J; Haridas V; Gaikwad A; Connolly F P; Mills G B; Gutterman J U
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Cell death and differentiation 2007;14(11):1948-57.
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2007: Berns Katrien; Horlings Hugo M; Hennessy Bryan T; Madiredjo Mandy; Hijmans E Marielle; Beelen Karin; Linn Sabine C; Gonzalez-Angulo Ana Maria; Stemke-Hale Katherine; Hauptmann Michael; Beijersbergen Roderick L; Mills Gordon B; van de Vijver Marc J; Bernards René
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Cancer cell 2007;12(4):395-402.
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2007: Lu Chien-Hsing; Wyszomierski Shannon L; Tseng Ling-Ming; Sun Meng-Hong; Lan Keng-Hsueh; Neal Christopher L; Mills Gordon B; Hortobagyi Gabriel N; Esteva Francisco J; Yu Dihua
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5883-8.
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2007: Guan Yinghui; Kuo Wen-Lin; Stilwell Jackie L; Takano Hirokuni; Lapuk Anna V; Fridlyand Jane; Mao Jian-Hua; Yu Mamie; Miller Melinda A; Santos Jennifer L; Kalloger Steve E; Carlson Joseph W; Ginzinger David G; Celniker Susan E; Mills Gordon B; Huntsman David G; Gray Joe W
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5745-55.
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2007: Fujiwara Keishi; Iwado Eiji; Mills Gordon B; Sawaya Raymond; Kondo Seiji; Kondo Yasuko
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
International journal of oncology 2007;31(4):753-60.
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2007: Lu Yang; Li Xinqun; Liang Ke; Luwor Rodney; Siddik Zahid H; Mills Gordon B; Mendelsohn John; Fan Zhen
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
Cancer research 2007;67(17):8240-7.
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2007: Aoki Hiroshi; Iwado Eiji; Eller Mark S; Kondo Yasuko; Fujiwara Keishi; Li Guang-Zhi; Hess Kenneth R; Siwak Doris R; Sawaya Raymond; Mills Gordon B; Gilchrest Barbara A; Kondo Seiji
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2918-30.
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2007: Estrella Veronica C; Eder Astrid M; Liu Shuying; Pustilnik Terri B; Tabassam Fazal H; Claret Francois X; Gallick Gary E; Mills Gordon B; Wiener Jon R
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
International journal of oncology 2007;31(2):441-9.
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2007: Yamasaki Fumiyuki; Johansen Mary J; Zhang Dongwei; Krishnamurthy Savitri; Felix Edward; Bartholomeusz Chandra; Aguilar Richard J; Kurisu Kaoru; Mills Gordon B; Hortobagyi Gabriel N; Ueno Naoto T
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Cancer research 2007;67(12):5779-88.
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2007: Zhang Qing; Bhola Neil E; Lui Vivian Wai Yan; Siwak Doris R; Thomas Sufi M; Gubish Christopher T; Siegfried Jill M; Mills Gordon B; Shin Dong; Grandis Jennifer Rubin
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Molecular cancer therapeutics 2007;6(4):1414-24.
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2007: Nanjundan Meera; Nakayama Yasuhisa; Cheng Kwai Wa; Lahad John; Liu Jinsong; Lu Karen; Kuo Wen-Lin; Smith-McCune Karen; Fishman David; Gray Joe W; Mills Gordon B
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Cancer research 2007;67(7):3074-84.
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2007: Fang Dexing; Hawke David; Zheng Yanhua; Xia Yan; Meisenhelder Jill; Nika Heinz; Mills Gordon B; Kobayashi Ryuji; Hunter Tony; Lu Zhimin
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
The Journal of biological chemistry 2007;282(15):11221-9.
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2007: Nanjundan M; Zhang F; Schmandt R; Smith-McCune K; Mills G B
Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
Oncogene 2007;26(18):2574-84.
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2007: Iwamaru A; Kondo Y; Iwado E; Aoki H; Fujiwara K; Yokoyama T; Mills G B; Kondo S
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Oncogene 2007;26(13):1840-51.
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2007: Liang Jiyong; Shao Shan H; Xu Zhi-Xiang; Hennessy Bryan; Ding Zhiyong; Larrea Michelle; Kondo Seiji; Dumont Dan J; Gutterman Jordan U; Walker Cheryl L; Slingerland Joyce M; Mills Gordon B
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Nature cell biology 2007;9(2):218-24.
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2007: Tabe Yoko; Jin Linhua; Tsutsumi-Ishii Yuko; Xu Yuanyuan; McQueen Teresa; Priebe Waldemar; Mills Gordon B; Ohsaka Akimichi; Nagaoka Isao; Andreeff Michael; Konopleva Marina
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Cancer research 2007;67(2):684-94.
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2007: Younes Maher N; Yigitbasi Orhan G; Yazici Yasemin D; Jasser Samar A; Bucana Cora D; El-Naggar Adel K; Mills Gordon B; Myers Jeffrey N
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Archives of otolaryngology--head & neck surgery 2007;133(1):15-23.
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2007: Yang Gong; Rosen Daniel G; Mercado-Uribe Imelda; Colacino Justin A; Mills Gordon B; Bast Robert C; Zhou Chenyi; Liu Jinsong
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Carcinogenesis 2007;28(1):174-82.
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2007: Murph Mandi; Mills Gordon B
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Expert reviews in molecular medicine 2007;9(28):1-18.
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2007: Bast Robert C; Brewer Molly; Zou Changping; Hernandez Mary A; Daley Mary; Ozols Robert; Lu Karen; Lu Zhen; Badgwell Donna; Mills Gordon B; Skates Steven; Zhang Zhen; Chan Dan; Lokshin Anna; Yu Yinhua
Prevention and early detection of ovarian cancer: mission impossible?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():91-100.
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2006: Murph Mandi; Tanaka Tamotsu; Liu Shuying; Mills Gordon B
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6598-602.
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2006: Stemke-Hale Katherine; Hennessy Bryan; Mills Gordon B; Mitra Rahul
Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein.
Current oncology reports 2006;8(6):484-91.
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2006: Yang Gong; Rosen Daniel G; Zhang Zhihong; Bast Robert C; Mills Gordon B; Colacino Justin A; Mercado-Uribe Imelda; Liu Jinsong
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16472-7.
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2006: Tibes Raoul; Qiu Yihua; Lu Yiling; Hennessy Bryan; Andreeff Michael; Mills Gordon B; Kornblau Steven M
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Molecular cancer therapeutics 2006;5(10):2512-21.
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2006: Ding Zhiyong; Liang Jiyong; Lu Yiling; Yu Qinghua; Songyang Zhou; Lin Shiaw-Yih; Mills Gordon B
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15014-9.
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2006: Rai Rekha; Dai Hui; Multani Asha S; Li Kaiyi; Chin Koei; Gray Joe; Lahad John P; Liang Jiyong; Mills Gordon B; Meric-Bernstam Funda; Lin Shiaw-Yih
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Cancer cell 2006;10(2):145-57.
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2006: Baker Daniel L; Fujiwara Yuko; Pigg Kathryn R; Tsukahara Ryoko; Kobayashi Susumu; Murofushi Hiromu; Uchiyama Ayako; Murakami-Murofushi Kimiko; Koh Eunjin; Bandle Russell W; Byun Hoe-Sup; Bittman Robert; Fan Dominic; Murph Mandi; Mills Gordon B; Tigyi Gabor
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
The Journal of biological chemistry 2006;281(32):22786-93.
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2006: Zhang Qing; Thomas Sufi M; Lui Vivian Wai Yan; Xi Sichuan; Siegfried Jill M; Fan Huizhou; Smithgall Thomas E; Mills Gordon B; Grandis Jennifer Rubin
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6901-6.
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2006: Rosen Daniel G; Yang Gong; Deavers Michael T; Malpica Anais; Kavanagh John J; Mills Gordon B; Liu Jinsong
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.
Cancer 2006;106(9):1925-32.
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2006: Li Xinqun; Lu Yang; Jin Weidong; Liang Ke; Mills Gordon B; Fan Zhen
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
The Journal of biological chemistry 2006;281(19):13837-43.
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2006: Zeng Zhihong; Samudio Ismael J; Zhang Weiguo; Estrov Zeev; Pelicano Hélène; Harris David; Frolova Olga; Hail Numsen; Chen Wenjing; Kornblau Steven M; Huang Peng; Lu Yiling; Mills Gordon B; Andreeff Michael; Konopleva Marina
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Cancer research 2006;66(7):3737-46.
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2006: Mandal Mahitosh; Younes Maher; Swan Eric A; Jasser Samar A; Doan Dao; Yigitbasi Orhan; McMurphey Andrea; Ludwick James; El-Naggar Adel K; Bucana Cora; Mills Gordon B; Myers Jeffrey N
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Oral oncology 2006;42(4):430-9.
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2006: Hennessy Bryan T; Nanjundan Meera; Cheng Kwai Wa; Nolden Laura; Mills Gordon B
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
European journal of human genetics : EJHG 2006;14(4):381-3.
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2006: Qian Lian; Xu Yong; Simper Ted; Jiang Guowei; Aoki Junken; Umezu-Goto Makiko; Arai Hiroyuki; Yu Shuangxing; Mills Gordon B; Tsukahara Ryoko; Makarova Natalia; Fujiwara Yuko; Tigyi Gabor; Prestwich Glenn D
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
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2006: Koul Dimpy; Shen Ruijun; Bergh Sherry; Sheng Xiaoyang; Shishodia Shishir; Lafortune Tiffany A; Lu Yiling; de Groot John F; Mills Gordon B; Yung W K Alfred
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Molecular cancer therapeutics 2006;5(3):637-44.
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2006: Zhu Quan-Sheng; Xia Ling; Mills Gordon B; Lowell Clifford A; Touw Ivo P; Corey Seth J
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
Blood 2006;107(5):1847-56.
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2006: Georgakis Georgios V; Li Yang; Rassidakis Georgios Z; Medeiros L Jeffrey; Mills Gordon B; Younes Anas
Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
British journal of haematology 2006;132(4):503-11.
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2006: Barcenas Carlos H; Hosain G M Monawar; Arun Banu; Zong Jihong; Zhou Xiaojun; Chen Jianfang; Cortada Jill M; Mills Gordon B; Tomlinson Gail E; Miller Alexander R; Strong Louise C; Amos Christopher I
Assessing BRCA carrier probabilities in extended families.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(3):354-60.
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2006: Hennessy B T; Mills G B
Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling.
The international journal of biochemistry & cell biology 2006;38(9):1450-6.
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2005: Hennessy Bryan T; Smith Debra L; Ram Prahlad T; Lu Yiling; Mills Gordon B
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Nature reviews. Drug discovery 2005;4(12):988-1004.
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2005: Koul Dimpy; Shen Ruijun; Bergh Sherry; Lu Yiling; de Groot John F; Liu Ta Jen; Mills Gordon B; Yung W K Alfred
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Molecular cancer therapeutics 2005;4(11):1681-8.
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2005: Marquez Rebecca T; Baggerly Keith A; Patterson Andrea P; Liu Jinsong; Broaddus Russell; Frumovitz Michael; Atkinson Edward N; Smith David I; Hartmann Lynn; Fishman David; Berchuck Andrew; Whitaker Regina; Gershenson David M; Mills Gordon B; Bast Robert C; Lu Karen H
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6116-26.
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2005: Eder Astrid M; Sui Xiaomei; Rosen Daniel G; Nolden Laura K; Cheng Kwai Wa; Lahad John P; Kango-Singh Madhuri; Lu Karen H; Warneke Carla L; Atkinson Edward N; Bedrosian Isabelle; Keyomarsi Khandan; Kuo Wen-lin; Gray Joe W; Yin Jerry C P; Liu Jinsong; Halder Georg; Mills Gordon B
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12519-24.
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2005: Younes Maher N; Kim Seungwon; Yigitbasi Orhan G; Mandal Mahitosh; Jasser Samar A; Dakak Yazici Yasemin; Schiff Bradley A; El-Naggar Adel; Bekele Benjamin N; Mills Gordon B; Myers Jeffrey N
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Molecular cancer therapeutics 2005;4(8):1146-56.
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2005: Nishimoto Arata; Yu Yinhua; Lu Zhen; Mao Xiang; Ren Zhiyong; Watowich Stephanie S; Mills Gordon B; Liao Warren S-L; Chen Xiaomin; Bast Robert C; Luo Robert Z
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Cancer research 2005;65(15):6701-10.
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2005: Liu Zhensheng; Wang Li-E; Wang Luo; Lu Karen H; Mills Gordon B; Bondy Melissa L; Wei Qingyi
Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4968-76.
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2005: Lahad John P; Mills Gordon B; Coombes Kevin R
Stem cell-ness: a "magic marker" for cancer.
The Journal of clinical investigation 2005;115(6):1463-7.
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2005: Mandal M; Kim S; Younes M N; Jasser S A; El-Naggar A K; Mills G B; Myers J N
The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
British journal of cancer 2005;92(10):1899-905.
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2005: Xu Yong; Aoki Junken; Shimizu Kumiko; Umezu-Goto Makiko; Hama Kotaro; Takanezawa Yasukazu; Yu Shuangxing; Mills Gordon B; Arai Hiroyuki; Qian Lian; Prestwich Glenn D
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
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2005: Takeuchi Hayato; Kondo Yasuko; Fujiwara Keishi; Kanzawa Takao; Aoki Hiroshi; Mills Gordon B; Kondo Seiji
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Cancer research 2005;65(8):3336-46.
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2005: Cheng Kwai W; Lahad John P; Gray Joseph W; Mills Gordon B
Emerging role of RAB GTPases in cancer and human disease.
Cancer research 2005;65(7):2516-9.
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2005: Sheehan Katherine M; Calvert Valerie S; Kay Elaine W; Lu Yiling; Fishman David; Espina Virginia; Aquino Joy; Speer Runa; Araujo Robyn; Mills Gordon B; Liotta Lance A; Petricoin Emanuel F; Wulfkuhle Julia D
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
Molecular & cellular proteomics : MCP 2005;4(4):346-55.
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2005: Dong Jinjiang; Peng Junying; Zhang Haixia; Mondesire Wallace H; Jian Weiguo; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 2005;65(5):1961-72.
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2005: Le Xiao-Feng; Lammayot Amy; Gold David; Lu Yiling; Mao Weiqun; Chang Teresa; Patel Adarsh; Mills Gordon B; Bast Robert C
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
The Journal of biological chemistry 2005;280(3):2092-104.
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2004: Meric-Bernstam Funda; Mills Gordon B
Mammalian target of rapamycin.
Seminars in oncology 2004;31(6 Suppl 16):10-7; discussion 33.
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2004: Liu Shuying; Yu Shuangxing; Hasegawa Yutaka; Lapushin Ruth; Xu Hong-Ji; Woodgett James R; Mills Gordon B; Fang Xianjun
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
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2004: Cheng Kwai Wa; Lahad John P; Kuo Wen-Lin; Lapuk Anna; Yamada Kyosuke; Auersperg Nelly; Liu Jinsong; Smith-McCune Karen; Lu Karen H; Fishman David; Gray Joe W; Mills Gordon B
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Nature medicine 2004;10(11):1251-6.
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2004: Mondesire Wallace H; Jian Weiguo; Zhang Haixia; Ensor Joe; Hung Mien-Chie; Mills Gordon B; Meric-Bernstam Funda
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7031-42.
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2004: Umezu-Goto Makiko; Tanyi Janos; Lahad John; Liu Shuying; Yu Shuangxing; Lapushin Ruth; Hasegawa Yutaka; Lu Yiling; Trost Rosanne; Bevers Therese; Jonasch Eric; Aldape Ken; Liu Jinsong; James Robyn D; Ferguson Colin G; Xu Yong; Prestwich Glenn D; Mills Gordon B
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
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2004: Lu Karen H; Patterson Andrea P; Wang Lin; Marquez Rebecca T; Atkinson Edward N; Baggerly Keith A; Ramoth Lance R; Rosen Daniel G; Liu Jinsong; Hellstrom Ingegerd; Smith David; Hartmann Lynn; Fishman David; Berchuck Andrew; Schmandt Rosemarie; Whitaker Regina; Gershenson David M; Mills Gordon B; Bast Robert C
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3291-300.
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2004: Cheng Kwai Wa; Lahad John P; Mills Gordon B
Analysis of molecular aberrations in ovarian cancer allows novel target identification.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC 2004;26(5):461-74.
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2004: Sellappan Shankar; Grijalva Rebecca; Zhou Xiaoyan; Yang Wentao; Eli Menashe Bar; Mills Gordon B; Yu Dihua
Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line.
Cancer research 2004;64(10):3479-85.
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2004: Liu Jinsong; Yang Gong; Thompson-Lanza Jennifer A; Glassman Armand; Hayes Kimberly; Patterson Andrea; Marquez Rebecca T; Auersperg Nelly; Yu Yinhua; Hahn William C; Mills Gordon B; Bast Robert C
A genetically defined model for human ovarian cancer.
Cancer research 2004;64(5):1655-63.
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2004: Fang Xianjun; Yu Shuangxing; Bast Robert C; Liu Shuying; Xu Hong-Ji; Hu Shi-Xue; LaPushin Ruth; Claret Francois X; Aggarwal Bharat B; Lu Yiling; Mills Gordon B
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
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2004: Kohn Elise C; Lu Yiling; Wang Hongwei; Yu Qinghua; Yu Shuangxing; Hall Hassan; Smith Debra L; Meric-Bernstam Funda; Hortobagyi Gabriel N; Mills Gordon B
Molecular therapeutics: promise and challenges.
Seminars in oncology 2004;31(1 Suppl 3):39-53.
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2004: Noh Woo-Chul; Mondesire Wallace H; Peng Junying; Jian Weiguo; Zhang Haixia; Dong JinJiang; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Determinants of rapamycin sensitivity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1013-23.
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2004: Zhao S; Konopleva M; Cabreira-Hansen M; Xie Z; Hu W; Milella M; Estrov Z; Mills G B; Andreeff M
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(2):267-75.
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2004: Andreeff M; Milella M; Carter B Z; Tabe Y; Ricciardi M R; Sneed T; Ruvolo P; Contractor R; Tsao T; Schober W; Evans R; McQueen T; Zeng Z; Kornblau S M; McCubrey J; Estey E; Mills G B; Reed J C; Konopleva M
Targeted therapy of AML new concepts.
Annals of hematology 2004;83 Suppl 1():S51-3.
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2003: Qian Lian; Xu Yong; Hasegawa Yutaka; Aoki Junken; Mills Gordon B; Prestwich Glenn D
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Journal of medicinal chemistry 2003;46(26):5575-8.
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2003: Mills Gordon B; Kohn Elise; Lu Yiling; Eder Astrid; Fang Xianjun; Wang Hongwei; Bast Robert C; Gray Joe; Jaffe Robert; Hortobagyi Gabriel
Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):93-104.
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2003: Lu Yiling; Yu Qinghua; Liu Jue Hui; Zhang Jinyi; Wang Hongwei; Koul Dimpy; McMurray John S; Fang Xianjun; Yung W K Alfred; Siminovitch Kathy A; Mills Gordon B
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
The Journal of biological chemistry 2003;278(41):40057-66.
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2003: Tanyi Janos L; Hasegawa Yutaka; Lapushin Ruth; Morris Andrew J; Wolf Judith K; Berchuck Andrew; Lu Karen; Smith David I; Kalli Kimberly; Hartmann Lynn C; McCune Karen; Fishman David; Broaddus Russell; Cheng Kwai W; Atkinson Edward N; Yamal Jose M; Bast Robert C; Felix Edward A; Newman Robert A; Mills Gordon B
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3534-45.
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2003: Clair Timothy; Aoki Junken; Koh Eunjin; Bandle Russell W; Nam Suk Woo; Ptaszynska Malgorzata M; Mills Gordon B; Schiffmann Elliott; Liotta Lance A; Stracke Mary L
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer research 2003;63(17):5446-53.
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2003: Hu S X; Wang S; Wang J P; Mills G B; Zhou Y; Xu H-J
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
British journal of cancer 2003;89(1):135-9.
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2003: Shvartsman Hyun S; Lu Karen H; Lee John; Lillie Jim; Deavers Michael T; Clifford Stephanie; Wolf Judith K; Mills Gordon B; Bast Robert C; Gershenson David M; Schmandt Rosemarie
Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
Gynecologic oncology 2003;90(1):44-50.
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2003: Lu Yiling; Wang Hongwei; Mills Gordon B
Targeting PI3K-AKT pathway for cancer therapy.
Reviews in clinical and experimental hematology 2003;7(2):205-28.
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2003: Lee Ho-Young; Srinivas Harish; Xia Dianren; Lu Yiling; Superty Robert; LaPushin Ruth; Gomez-Manzano Candelaria; Gal Anna Maria; Walsh Garrett L; Force Thomas; Ueki Kohjiro; Mills Gordon B; Kurie Jonathan M
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
The Journal of biological chemistry 2003;278(26):23630-8.
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2003: Luo Robert Z; Fang Xianjun; Marquez Rebecca; Liu Shu-Ying; Mills Gordon B; Liao Warren S-L; Yu Yinhua; Bast Robert C
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Oncogene 2003;22(19):2897-909.
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2003: Knuefermann Christiane; Lu Yang; Liu Bolin; Jin Weidong; Liang Ke; Wu Ling; Schmidt Mathias; Mills Gordon B; Mendelsohn John; Fan Zhen
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Oncogene 2003;22(21):3205-12.
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2003: Mansouri Abdellah; Ridgway Lon D; Korapati Anita L; Zhang Qingxiu; Tian Ling; Wang Yibin; Siddik Zahid H; Mills Gordon B; Claret François X
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
The Journal of biological chemistry 2003;278(21):19245-56.
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2003: Liang Ke; Jin Weidong; Knuefermann Christiane; Schmidt Mathias; Mills Gordon B; Ang K Kian; Milas Luka; Fan Zhen
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Molecular cancer therapeutics 2003;2(4):353-60.
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2003: Cui Xiaojiang; Zhang Ping; Deng Wanleng; Oesterreich Steffi; Lu Yiling; Mills Gordon B; Lee Adrian V
Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):575-88.
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2003: Hasegawa Yutaka; Erickson James R; Goddard Graham J; Yu Shuangxing; Liu Shuying; Cheng Kwai Wa; Eder Astrid; Bandoh Koji; Aoki Junken; Jarosz Renata; Schrier Andrew D; Lynch Kevin R; Mills Gordon B; Fang Xianjun
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
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2003: Tanyi Janos L; Morris Andrew J; Wolf Judith K; Fang Xianjun; Hasegawa Yutaka; Lapushin Ruth; Auersperg Nelly; Sigal Yury J; Newman Robert A; Felix Edward A; Atkinson Edward N; Mills Gordon B
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
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2003: Aytac U; Sato K; Yamochi T; Yamochi T; Ohnuma K; Mills G B; Morimoto C; Dang N H
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
British journal of cancer 2003;88(3):455-62.
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2003: Mills Gordon B; Fang Xianjun; Lu Yiling; Hasegawa Yutaka; Eder Astrid; Tanyi Janos; Tabassam Fazad Haq; Mao Muling; Wang Hongwei; Cheng Kwai Wa; Nakayama Yasuhisa; Kuo Wenlin; Erickson Jim; Gershenson David; Kohn Elise C; Jaffe Robert; Bast Robert C; Gray Joe
Specific keynote: molecular therapeutics in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S88-92; discussion S93-6.
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2003: Bast Robert C; Mills Gordon B
General keynote: molecular therapeutics and pharmocogenomics.
Gynecologic oncology 2003;88(1 Pt 2):S84-7; discussion S93-6.
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2003: Liotta Lance A; Petricoin Emanuel F; Ardekani Ali M; Hitt Ben A; Levine Peter J; Fusaro Vincent A; Steinberg Seth M; Mills Gordon B; Simone Charles; Fishman David A; Kohn Elise C
General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S25-8; discussion S37-42.
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2003: Gray Joe W; Suzuki Seiji; Kuo Wen-Lin; Polikoff Daniel; Deavers Michael; Smith-McCune Karen; Berchuck Andrew; Pinkel Dan; Albertson Donna; Mills Gordon B
Specific keynote: genome copy number abnormalities in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S16-21; discussion S22-4.
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2003: Le Xiao-Feng; Hittelman Walter N; Liu Jiaxin; McWatters Amanda; Li Chun; Mills Gordon B; Bast Robert C
Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.
Oncogene 2003;22(4):484-97.
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2003: Wiener Jon R; Windham T Christopher; Estrella Veronica C; Parikh Nila U; Thall Peter F; Deavers Michael T; Bast Robert C; Mills Gordon B; Gallick Gary E
Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.
Gynecologic oncology 2003;88(1):73-9.
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2002: Bondar Victor M; Sweeney-Gotsch Bridget; Andreeff Michael; Mills Gordon B; McConkey David J
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Molecular cancer therapeutics 2002;1(12):989-97.
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2002: Umezu-Goto Makiko; Kishi Yasuhiro; Taira Akitsu; Hama Kotaro; Dohmae Naoshi; Takio Koji; Yamori Takao; Mills Gordon B; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
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2002: Tanyi Janos L; Lapushin Ruth; Eder Astrid; Auersperg Nelly; Tabassam Fazal H; Roth Jack A; Gu Jian; Fang Binglian; Mills Gordon B; Wolf Judith
Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Gynecologic oncology 2002;85(3):451-8.
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2002: Fang Xianjun; Schummer Michel; Mao Muling; Yu Shuangxing; Tabassam Fazal Haq; Swaby Ramona; Hasegawa Yutaka; Tanyi Janos L; LaPushin Ruthie; Eder Astrid; Jaffe Robert; Erickson Jim; Mills Gordon B
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
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2002: Koul Dimpy; Jasser Samar A; Lu Yiling; Davies Michael A; Shen Ruijun; Shi Yuexi; Mills Gordon B; Yung W K Alfred
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Oncogene 2002;21(15):2357-64.
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2002: Fang Xianjun; Yu Shuangxing; Tanyi Janos L; Lu Yiling; Woodgett James R; Mills Gordon B
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology 2002;22(7):2099-110.
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2002: Kuo Macus Tien; Liu Zesheng; Wei Yingjie; Lin-Lee Yen-chiu; Tatebe Shigeru; Mills Gordon B; Unate Hitoshi
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.
Oncogene 2002;21(13):1945-54.
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2002: Petricoin Emanuel F; Ardekani Ali M; Hitt Ben A; Levine Peter J; Fusaro Vincent A; Steinberg Seth M; Mills Gordon B; Simone Charles; Fishman David A; Kohn Elise C; Liotta Lance A
Use of proteomic patterns in serum to identify ovarian cancer.
Lancet 2002;359(9306):572-7.
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2002: Buchholz Thomas A; Wu Xifeng; Hussain Abu; Tucker Susan L; Mills Gordon B; Haffty Bruce; Bergh Sherry; Story Michael; Geara Fady B; Brock William A
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
International journal of cancer. Journal international du cancer 2002;97(5):557-61.
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2002: Mills Gordon B; Eder Astrid; Fang Xianjun; Hasegawa Yutaka; Mao Muling; Lu Yiling; Tanyi Janos; Tabassam Fazal Haq; Wiener Jon; Lapushin Ruth; Yu Shiangxing; Parrott Jeff A; Compton Tim; Tribley Walter; Fishman David; Stack M Sharon; Gaudette Douglas; Jaffe Robert; Furui Tatsuro; Aoki Junken; Erickson James R
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
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2001: Le X F; Marcelli M; McWatters A; Nan B; Mills G B; O'Brian C A; Bast R C
Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Oncogene 2001;20(57):8258-69.
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2001: Zhu Y; Spitz M R; Lei L; Mills G B; Wu X
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility.
Cancer research 2001;61(21):7825-9.
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2001: Mills G B; Lu Y; Fang X; Wang H; Eder A; Mao M; Swaby R; Cheng K W; Stokoe D; Siminovitch K; Jaffe R; Gray J
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology 2001;28(5 Suppl 16):125-41.
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2001: Aytac U; Claret F X; Ho L; Sato K; Ohnuma K; Mills G B; Cabanillas F; Morimoto C; Dang N H
Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint.
Cancer research 2001;61(19):7204-10.
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2001: Mills G B; Lu Y; Kohn E C
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10031-3.
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2001: Shridhar V; Lee J; Pandita A; Iturria S; Avula R; Staub J; Morrissey M; Calhoun E; Sen A; Kalli K; Keeney G; Roche P; Cliby W; Lu K; Schmandt R; Mills G B; Bast R C; James C D; Couch F J; Hartmann L C; Lillie J; Smith D I
Genetic analysis of early- versus late-stage ovarian tumors.
Cancer research 2001;61(15):5895-904.
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2001: Liu B; Fang M; Lu Y; Lu Y; Mills G B; Fan Z
Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
British journal of cancer 2001;85(2):303-11.
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2001: Mujoo K; Haridas V; Hoffmann J J; Wächter G A; Hutter L K; Lu Y; Blake M E; Jayatilake G S; Bailey D; Mills G B; Gutterman J U
Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
Cancer research 2001;61(14):5486-90.
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2001: Ho L; Aytac U; Stephens L C; Ohnuma K; Mills G B; McKee K S; Neumann C; LaPushin R; Cabanillas F; Abbruzzese J L; Morimoto C; Dang N H
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2031-40.
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2001: Cuevas B D; Lu Y; Mao M; Zhang J; LaPushin R; Siminovitch K; Mills G B
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(29):27455-61.
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2001: Erickson J R; Hasegawa Y; Fang X; Eder A; Mao M; Furui T; Aoki J; Morris A; Mills G B
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
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2000: Kruzelock R P; Cuevas B D; Wiener J R; Xu F J; Yu Y; Cabeza-Arvelaiz Y; Pershouse M; Lovell M M; Killary A M; Mills G B; Bast R C
Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
Oncogene 2000;19(54):6277-85.
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2000: Mao M; Fang X; Lu Y; Lapushin R; Bast R C; Mills G B
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
The Biochemical journal 2000;352 Pt 2():475-82.
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2000: Fang X; Yu S; LaPushin R; Lu Y; Furui T; Penn L Z; Stokoe D; Erickson J R; Bast R C; Mills G B
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
The Biochemical journal 2000;352 Pt 1():135-43.
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2000: Fang X; Yu S X; Lu Y; Bast R C; Woodgett J R; Mills G B
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11960-5.
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2000: Le X F; Vadlamudi R; McWatters A; Bae D S; Mills G B; Kumar R; Bast R C
Differential signaling by an anti-p185(HER2) antibody and heregulin.
Cancer research 2000;60(13):3522-31.
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2000: Eder A M; Sasagawa T; Mao M; Aoki J; Mills G B
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2482-91.
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2000: Fang X; Gaudette D; Furui T; Mao M; Estrella V; Eder A; Pustilnik T; Sasagawa T; Lapushin R; Yu S; Jaffe R B; Wiener J R; Erickson J R; Mills G B
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Annals of the New York Academy of Sciences 2000;905():188-208.
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2000: Ramondetta L; Mills G B; Burke T W; Wolf J K
Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):278-84.
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2000: Le X F; McWatters A; Wiener J; Wu J Y; Mills G B; Bast R C
Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):260-70.
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1999: Furui T; LaPushin R; Mao M; Khan H; Watt S R; Watt M A; Lu Y; Fang X; Tsutsui S; Siddik Z H; Bast R C; Mills G B
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4308-18.
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1999: Gershenson D M; Deavers M; Diaz S; Tortolero-Luna G; Miller B E; Bast R C; Mills G B; Silva E G
Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4053-8.
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1999: Lu Y; Lin Y Z; LaPushin R; Cuevas B; Fang X; Yu S X; Davies M A; Khan H; Furui T; Mao M; Zinner R; Hung M C; Steck P; Siminovitch K; Mills G B
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
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1999: Fang X; Yu S; Eder A; Mao M; Bast R C; Boyd D; Mills G B
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway.
Oncogene 1999;18(48):6635-40.
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1999: Pustilnik T B; Estrella V; Wiener J R; Mao M; Eder A; Watt M A; Bast R C; Mills G B
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3704-10.
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1999: Xu F; Yu Y; Le X F; Boyer C; Mills G B; Bast R C
The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3653-60.
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1999: Wolf J K; Mills G B; Bazzet L; Bast R C; Roth J A; Gershenson D M
Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
Gynecologic oncology 1999;75(2):261-6.
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1999: Cuevas B; Lu Y; Watt S; Kumar R; Zhang J; Siminovitch K A; Mills G B
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
The Journal of biological chemistry 1999;274(39):27583-9.
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1999: Zebrowski B K; Liu W; Ramirez K; Akagi Y; Mills G B; Ellis L M
Markedly elevated levels of vascular endothelial growth factor in malignant ascites.
Annals of surgical oncology 1999;6(4):373-8.
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1999: Hagopian G S; Mills G B; Khokhar A R; Bast R C; Siddik Z H
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):655-63.
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1999: Yu Y; Xu F; Peng H; Fang X; Zhao S; Li Y; Cuevas B; Kuo W L; Gray J W; Siciliano M; Mills G B; Bast R C
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):214-9.
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1998: Davies M A; Lu Y; Sano T; Fang X; Tang P; LaPushin R; Koul D; Bookstein R; Stokoe D; Yung W K; Mills G B; Steck P A
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.
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1998: Lu Y; Cuevas B; Gibson S; Khan H; LaPushin R; Imboden J; Mills G B
Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5404-12.
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1998: Bast R C; Xu F J; Yu Y H; Barnhill S; Zhang Z; Mills G B
CA 125: the past and the future.
The International journal of biological markers 1998;13(4):179-87.
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1998: Koul D; Obeyesekere N U; Gutterman J U; Mills G B; Choubey D
p202 self-associates through a sequence conserved among the members of the 200-family proteins.
FEBS letters 1998;438(1-2):21-4.
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1998: Koul D; Lapushin R; Xu H J; Mills G B; Gutterman J U; Choubey D
p202 prevents apoptosis in murine AKR-2B fibroblasts.
Biochemical and biophysical research communications 1998;247(2):379-82.
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1998: Gibson S; Truitt K; Lu Y; Lapushin R; Khan H; Imboden J B; Mills G B
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
The Biochemical journal 1998;330 ( Pt 3)():1123-8.
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1998: Fang X; Jin X; Xu H J; Liu L; Peng H Q; Hogg D; Roth J A; Yu Y; Xu F; Bast R C; Mills G B
Expression of p16 induces transcriptional downregulation of the RB gene.
Oncogene 1998;16(1):1-8.
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1997: Teng D H; Hu R; Lin H; Davis T; Iliev D; Frye C; Swedlund B; Hansen K L; Vinson V L; Gumpper K L; Ellis L; El-Naggar A; Frazier M; Jasser S; Langford L A; Lee J; Mills G B; Pershouse M A; Pollack R E; Tornos C; Troncoso P; Yung W K; Fujii G; Berson A; Steck P A
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Cancer research 1997;57(23):5221-5.
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1997: Xu H J; Zhou Y; Ji W; Perng G S; Kruzelock R; Kong C T; Bast R C; Mills G B; Li J; Hu S X
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition.
Oncogene 1997;15(21):2589-96.
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1997: Xu F J; Stack S; Boyer C; O'Briant K; Whitaker R; Mills G B; Yu Y H; Bast R C
Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1629-34.
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1997: Fang X; Gibson S; Flowers M; Furui T; Bast R C; Mills G B
Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
The Journal of biological chemistry 1997;272(21):13683-9.
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1996: Gibson S; August A; Kawakami Y; Kawakami T; Dupont B; Mills G B
The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2716-22.
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1995: Truitt K E; Shi J; Gibson S; Segal L G; Mills G B; Imboden J B
CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4702-10.
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1995: Goldsmith M A; Lai S Y; Xu W; Amaral M C; Kuczek E S; Parent L J; Mills G B; Tarr K L; Longmore G D; Greene W C
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
The Journal of biological chemistry 1995;270(37):21729-37.
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1994: Truitt K E; Mills G B; Turck C W; Imboden J B
SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
The Journal of biological chemistry 1994;269(8):5937-43.
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