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Gordon Mills

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Punashi Dutta; Khandan Keyomarsi; Gordon B Mills; Kyle A Bauckman; Tuyen Bui; Meera Nanjundan
EVI1 splice variants modulate functional responses in ovarian cancer cells.
Funda Meric-Bernstam; Carol Farhangfar; John Mendelsohn; Gordon B Mills
Building a personalized medicine infrastructure at a major cancer center.
Jiyong Liang; Gordon B Mills
AMPK: A Contextual Oncogene or Tumor Suppressor?

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All Publications

2013: Punashi Dutta; Khandan Keyomarsi; Gordon B Mills; Kyle A Bauckman; Tuyen Bui; Meera Nanjundan
EVI1 splice variants modulate functional responses in ovarian cancer cells.
Molecular oncology 2013;7(3):647-68.
2013: Funda Meric-Bernstam; Carol Farhangfar; John Mendelsohn; Gordon B Mills
Building a personalized medicine infrastructure at a major cancer center.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(15):1849-57.
2013: Jiyong Liang; Gordon B Mills
AMPK: A Contextual Oncogene or Tumor Suppressor?
Cancer research 2013;73(10):2929-35.
2013: Muling Mao; John M Mariadason; Gordon B Mills; Garth Powis; Xi M Tang; Feng Tian; Chun C Tsao; Ignacio I Wistuba; Gideon Bollag; William G Bornman; Michael A Davies; Farshid Dayyani; Jayesh Desai; Gary E Gallick; YN Vashisht Gopal; Zhi-Qin Jiang; Robert Lemos; Scott Kopetz
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(3):657-67.
2013: Kang Jin Jeong; Jaeku Kang; Hoon Kim; Gordon B Mills; Nattapon Panupinthu; Chang Gyo Park; Kyung Hwa Cho; Hoi Young Lee
EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol.
Molecular oncology 2013;7(1):121-9.
2013: Yixin Yao; Dos Sarbassov; Tattym E Shaiken; Milind Suraokar; James L Abbruzzese; Takayuki Asano; Benny H-J Chang; Chien-Hung Chen; Bryant G Darnay; Brett G Hollier; Yiling Lu; Sendurai Mani; Gordon B Mills; Shrikanth A G Reddy
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Science signaling 2013;6(257):ra2.
2013: Adel Tabchy; Nevine Eltonsy; David E Housman; Gordon B Mills
Systematic identification of combinatorial drivers and targets in cancer cell lines.
PloS one 2013;8(4):e60339.
2013: Ashley M Holder; Gabriel N Hortobagyi; Gordon B Mills; Lajos Pusztai; Argun Akcakanat; Huiqin Chen; Kim-Anh Do; W Fraser Symmans; Ana M Gonzalez-Angulo; Funda Meric-Bernstam
High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients.
Breast cancer research and treatment 2013;137(1):319-27.
2013: Ana M Gonzalez-Angulo; Gabriel N Hortobagyi; Meghan S Karuturi; Funda Meric-Bernstam; Gordon B Mills; Patricia A Thompson; Spyrus Tsavachidis; Melissa L Bondy; Mariana Chavez-MacGregor; Huiqin Chen; Kim-Anh Do; George R Blumenschein
Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer.
Cancer 2013;119(1):7-15.
2012: Shreya Mitra; Kwai W Cheng; Gordon B Mills
Rab25 in cancer: a brief update.
Biochemical Society transactions 2012;40(6):1404-8.
2012: Han Liang; Chang-Gong Liu; Xiuping Liu; Karen H Lu; Yiling Lu; Steven E Scherer; Kenneth L Scott; Katherine Stemke-Hale; Roeland G W Verhaak; Shannon N Westin; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Hannah Carter; Lydia W T Cheung; Turgut Dogruluk; Mary D Dyer; Chao Gu; Wei Guo; Bryan T Hennessy; Zhenlin Ju; Rachel Karchin; Jie Li; Gordon B Mills
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Genome research 2012;22(11):2120-9.
2012: Dalia Kamel; Gordon B Mills; Adel Tabchy; Bernadette Brady; Bryan Hennessy
Proteomic classification of breast cancer.
Current drug targets 2012;13(12):1495-509.
2012: Zheng D Liang; Yan Long; Gordon B Mills; Niramol Savaraj; Wen-Bin Tsai; Fan Zhang; Helen H W Chen; Siqing Fu; Mihai Gagea-Iurascu; Bryan T Hennessy; Razelle Kurzrock; M Tien Kuo
Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Molecular cancer therapeutics 2012;11(11):2483-94.
2012: X Li; K Liang; Ying Lu; Gordon B Mills; Constance T Albarracin; Jung-Mao Hsu; Mien-Chie Hung; Z Fan
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Oncogene 2012;31(40):4372-83.
2012: Chris J Oates; Bryan T Hennessy; Yiling Lu; Gordon B Mills; Sach Mukherjee
Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected].
Bioinformatics (Oxford, England) 2012;28(18):2342-8.
2012: Névine Eltonsy; Vivian Gabisi; Xuesong Li; Gordon B Mills; K Blair Russe; Katherine Stemke-Hale
Detection algorithm for the validation of human cell lines.
International journal of cancer. Journal international du cancer 2012;131(6):E1024-30.
2012: George R Blumenschein; Gordon B Mills; Ana M Gonzalez-Angulo
Targeting the hepatocyte growth factor-cMET axis in cancer therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(26):3287-96.
2012: Funda Meric-Bernstam; Gordon B Mills
Overcoming implementation challenges of personalized cancer therapy.
Nature reviews. Clinical oncology 2012;9(9):542-8.
2012: Luis E Nieto-Barajas; Peter Müller; Yuan Ji; Yiling Lu; Gordon B Mills
A time-series DDP for functional proteomics profiles.
Biometrics 2012;68(3):859-68.
2012: Fa-Xing Yu; Haixin Yuan; Bin Zhao; Jiagang Zhao; Jenna L Jewell; Hairi Li; Ian Lian; Gordon B Mills; Nattapon Panupinthu; Karen Tumaneng; Lloyd H Wang; Xiang-Dong Fu; Kun-Liang Guan
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Cell 2012;150(4):780-91.
2012: Bing Z Carter; Kevin R Coombes; Jorge Cortes; Lixia Diao; Xuelin Huang; Hagop M Kantarjian; Marina Konopleva; Duncan H Mak; Gordon B Mills; Yihua Qiu; Nianxiang Zhang; Michael Andreeff; Steven M Kornblau
Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.
Blood 2012;120(1):173-80.
2012: Haitao Ji; Bing-Hua Jiang; Zhiyong Ding; David Hawke; Gordon B Mills; Dongming Xing; Zhimin Lu
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
EMBO reports 2012;13(6):554-60.
2012: Zhiyong Ding; Zhehui Feng; Meng Gao; Peter German; Gordon B Mills; Wendy Si; Mary M Sobieski; Clifford C Stephan; Shanshan Bai; Eric Jonasch
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Journal of biomolecular screening 2012;17(5):572-80.
2012: Hong Mu; Victor G Prieto; Hua Wang; Gordon B Mills; Menashe Bar-Eli; Tiffany L Calderone; Michael A Davies; jeffrey gershenwald
Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells.
The American journal of pathology 2012;180(5):2170-81.
2012: Bojana Djordjevic; Bryan T Hennessy; Jie Li; Rajyalakshmi Luthra; Gordon B Mills; Bedia A Barkoh; Russell R Broaddus
Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012;25(5):699-708.
2012: Kanwal P Raghav; Wenting Wang; George R Blumenschein; Mariana Chavez-MacGregor; Gabriel N Hortobagyi; Shuying Liu; Xiaolong Meng; Funda Meric-Bernstam; Gordon B Mills; Ana M Gonzalez-Angulo
cMET and phospho-cMET protein levels in breast cancers and survival outcomes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(8):2269-77.
2012: Sarah Wheeler; Athanassios Argiris; Raymond Chai; Kathleen Cieply; Jennifer Rubin Grandis; Corwin Joy; Courtney LaValle; Gordon B Mills; Raja R Seethala; Carol Sherer; Jill M Siegfried; Doris R Siwak; Lin Wang; Ann Marie Egloff
Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(8):2278-89.
2012: Dai Horiuchi; Noelle E Huskey; Leonard Kusdra; Marc E Lenburg; Gordon B Mills; James W Smyth; Paul Yaswen; Alexey Bazarov; Sanjay Chandriani; Katelyn J Creasman; Sarah E Davis; Laura J Esserman; Ana Maria Gonzalez-Angulo; Andrei Goga
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
The Journal of experimental medicine 2012;209(4):679-96.
2012: B Dutta; Gabriel N Hortobagyi; V Lazar; Gordon B Mills; L Pusztai; Y Qi; C Y Shiang; W F Symmans; Naoto T Ueno; B Wang; R Agarwal; F André; G Bianchini; Gábor Balázsi
A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes.
British journal of cancer 2012;106(6):1107-16.
2012: Shreya Mitra; Katherine Stemke-Hale; Gordon B Mills; Sofie Claerhout
Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.
Cancer science 2012;103(3):400-7.
2012: Li-E Wang; Qingyi Wei; Ming Yin; Margaret R Spitz; Katherine S Hale; Bryan T Hennessy; Jie Li; Xuesong Li; Hongliang Liu; Karen H Lu; Hongxia Ma; Larissa A Meyer; Gordon B Mills
Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
Journal of cancer research and clinical oncology 2012;138(3):377-85.
2012: Ana M Gonzalez-Angulo; Gabriel N Hortobagyi; Takayuki Iwamoto; Shuying Liu; Funda Meric-Bernstam; Gordon B Mills; Huiqin Chen; Kim-Anh Do; W Fraser Symmans; Lajos Pusztai
Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(4):1109-19.
2012: Gordon B Mills
An emerging toolkit for targeted cancer therapies.
Genome research 2012;22(2):177-82.
2012: Kwai Wa Cheng; Joe W Gray; Ju Seog Lee; Roshan Agarwal; Mark Carey; Shreya Mitra; Gordon B Mills
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
EMBO molecular medicine 2012;4(2):125-41.
2012: Musaffe Tuna; Christopher I Amos; Zhenlin Ju; Gordon B Mills
Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy.
BMC medical genomics 2012;5():60.
2012: Steven N Quayle; Ruprecht Wiedemeyer; Richard K Wilson; Li Zhuang; Robert W Dewan; Li Ding; Emmet Huang-Hobbs; Jennifer Y Lee; Keith L Ligon; Gordon B Mills; Lewis C Cantley; Lydia W T Cheung; Lynda Chin
Somatic mutations of PIK3R1 promote gliomagenesis.
PloS one 2012;7(11):e49466.
2012: Huifang Guo; Bryan T Hennessy; Eric Jonasch; Zhenlin Ju; Wenbin Liu; Yiling Lu; Gordon B Mills; Pheroze Tamboli; Dimitra Tsavachidou
An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays.
Proteome science 2012;10(1):56.
2012: Yun-Yong Park; Bo Hwa Sohn; Gordon B Mills; Eun Sung Park; Lauren Averett Byers; In-Sun Chu; Woojin Jeong; Sang Bae Kim; Sang Cheol Kim; Ju Seog Lee
Development and validation of a prognostic gene-expression signature for lung adenocarcinoma.
PloS one 2012;7(9):e44225.
2012: Daisuke Hoshino; Jerome Jourquin; Yiling Lu; Tyne Miller; Gordon B Mills; Nagendra K Prasad; Vito Quaranta; Motoharu Seiki; Darren R Tyson; Brandee Brown; Kaitlin Costello; Shane Weller Emmons; Margalit Goldgof; Wendell G Yarbrough; Bing Zhang; Alissa M Weaver
Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis.
Science signaling 2012;5(241):ra66.
2012: Sofie Claerhout; Jennifer Dennison; Bhaskar Dutta; Yiling Lu; Catherine Nguyen-Charles; Qinghua Yu; Shuangxing Yu; Fan Zhang; Gábor Balázsi; Wouter Bossuyt; Gordon B Mills
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
PloS one 2012;7(6):e39400.
2012: Robert C Bast; Gordon B Mills
Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer.
Cancer discovery 2012;2(1):16-8.
2012: MyLinh T Duong; Kelly K Hunt; Said Akli; Wenbin Liu; Yiling Lu; Gordon B Mills; Caimiao Wei; Hannah Wingate; Min Yi; Khandan Keyomarsi
LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
PLoS genetics 2012;8(3):e1002538.
2011: Ju Seog Lee; Ji Hoon Kim; Yun-Yong Park; Gordon B Mills
Systems biology approaches to decoding the genome of liver cancer.
Cancer research and treatment : official journal of Korean Cancer Association 2011;43(4):205-11.
2011: Ying Lu; G Balazsi; J Donnelly; B Dutta; S Fesik; S Iadevaia; K Komurov; S Morgan-Lappe; M Muller; Luay Nakhleh; Prahlad T Ram; Derek Ruths; Mark E Schurdak; D Smith; J T Tseng; Q Yu; S Yu; Gordon B Mills
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.
Oncogene 2011;30(45):4567-77.
2011: Eun Sung Park; Yun-Yong Park; hyun goo woo; Se-Lyun Yoon; Jae-Ho Cheong; Isaiah J Fidler; Sang-Bae Kim; Sun Jin Kim; Soo Mi Kim; Seung Wook Kim; Sun-Hee Leem; Gordon B Mills; Ju Seog Lee
Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17456-61.
2011: Lydia W T Cheung; Bojana Djordjevic; Mary D Dyer; Bryan T Hennessy; Zhenlin Ju; Jie Li; Han Liang; Karen H Lu; Yiling Lu; Andrea P Myers; Steven E Scherer; Katherine Stemke-Hale; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Lewis C Cantley; Gordon B Mills
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Cancer discovery 2011;1(2):170-85.
2011: Ana M Gonzalez-Angulo; Gabriel N Hortobagyi; Shuying Liu; Ana Lluch; Juan A Barrera; Octavio Burgues; Huiqin Chen; Jaime Ferrer-Lozano; Gordon B Mills; Aysegul Sahin; Katherine Stemke-Hale; Funda Meric-Bernstam
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.
Molecular cancer therapeutics 2011;10(6):1093-101.
2011: Renuka Gupte; Renukadevi Patil; Jianxiong Liu; Yaohong Wang; Sue C Lee; Yuko Fujiwara; James Fells; Alyssa L Bolen; Karin Emmons-Thompson; C Ryan Yates; Anjaih Siddam; Nattapon Panupinthu; Truc-Chi T Pham; Daniel L Baker; Abby L Parrill; Gordon B Mills; Gabor Tigyi; Duane D Miller
Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
ChemMedChem 2011;6(5):922-35.
2011: Sun-Jin Kim; Jang-Seong Kim; Eun Sung Park; Ju Seog Lee; Qingtang Lin; Robert R Langley; Marva Maya; Junqin He; Seung-Wook Kim; Weihua Zhang; Krishnakumar Balasubramanian; Dominic Fan; Gordon B Mills; Mien-Chie Hung; Isaiah J Fidler
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
Neoplasia (New York, N.Y.) 2011;13(3):286-98.
2011: Ana M Gonzalez-Angulo; Kirsten M Timms; Shuying Liu; Huiqin Chen; Jennifer K Litton; Jennifer Potter; Jerry S Lanchbury; Katherine Stemke-Hale; Bryan T. J. Hennessy; Banu K Arun; Gabriel N Hortobagyi; Kim-Anh Do; Gordon B Mills; Funda Meric-Bernstam
Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(5):1082-9.
2011: J Suo; S J Snider; Gordon B Mills; C J Creighton; A C Chen; Rachel Schiff; Richard E Lloyd; E C Chang
Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.
Oncogene 2011;30(6):724-36.
2011: Adel Tabchy; B T Hennessy; A M Gonzalez-Angulo; F M Bernstam; Ying Lu; Gordon B Mills
Quantitative proteomic analysis in breast cancer.
Drugs of today (Barcelona, Spain : 1998) 2011;47(2):169-82.
2011: Adel Tabchy; Gabor Tigyi; Gordon B Mills
Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors.
Nature structural & molecular biology 2011;18(2):117-8.
2011: Shreya Mitra; Kwai W Cheng; Gordon B Mills
Rab GTPases implicated in inherited and acquired disorders.
Seminars in cell & developmental biology 2011;22(1):57-68.
2011: Quan-Sheng Zhu; K Rosenblatt; K-L Huang; G Lahat; R Brobey; Svetlana V Bolshakov; T Nguyen; Z Ding; R Belousov; K Bill; X Luo; Alexander Lazar; Adam Dicker; Gordon B Mills; Mien-Chie Hung; Dina lev
Vimentin is a novel AKT1 target mediating motility and invasion.
Oncogene 2011;30(4):457-70.
2011: Sofie Claerhout; KYOUNGHYUN Kim; Sang-Bae Kim; Ju Seog Lee; Jae Yun Lim; Gordon B Mills; Yun-Yong Park; Woonyoung Choi; Jae Yong Cho
Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
PloS one 2011;6(9):e24662.
2011: Ana M Gonzalez-Angulo; Bryan T Hennessy; Gabriel N Hortobagyi; Zhenlin Ju; Wenbin Liu; Ana Lluch; Funda Meric-Bernstam; Jan Alsner; Sam Aparicio; Anne-Lise Borresen-Dale; Russell Broaddus; Powel Brown; Mark S Carey; Kevin R Coombes; Lei Deng; Simen Myhre; Jens Overgaard; Lajos Pusztai; Aysegul Sahin; Corey Speers; W Fraser Symmans; Gordon B Mills
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer.
Clinical proteomics 2011;8(1):11.
2011: Chan H Han; Yu-Jing Huang; Karen H Lu; Zhensheng Liu; Gordon B Mills; Qingyi Wei; Li-E Wang
Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
Journal of experimental & clinical cancer research : CR 2011;30():5.
2010: Renuka Gupte; Anjaih Siddam; Yan Lu; Wei Li; Yuko Fujiwara; Nattapon Panupinthu; Truc-Chi Pham; Daniel L Baker; Abby L Parrill; Mari Gotoh; Kimiko Murakami-Murofushi; Susumu Kobayashi; Gordon B Mills; Gabor Tigyi; Duane D Miller
Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.
Bioorganic & medicinal chemistry letters 2010;20(24):7525-8.
2010: Xiaoyun Cheng; Weiya Xia; Jer-Yen Yang; Jennifer L Hsu; Chao-Kai Chou; Hui-Lung Sun; Shannon L Wyszomierski; Gordon B Mills; William J Muller; Dihua Yu; Mien-Chie Hung
Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
Biochemical and biophysical research communications 2010;403(1):103-7.
2010: Bryan T Hennessy; Zhenlin Ju; Wen-Lin Kuo; Wenbin Liu; Yiling Lu; Mollianne McGahren; Funda Meric-Bernstam; Roshan Agarwal; Jan Alsner; Isabelle Bedrosian; Anne-Lise Borresen-Dale; Mark S Carey; Kevin Coombes; Michael A Davies; Ana M Gonzalez-Angulo; Joe W Gray; Simen Myhre; Richard M Neve; Jens Overgaard; Fan Zhang; Gordon B Mills
A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers.
Clinical proteomics 2010;6(4):129-51.
2010: Meera Nanjundan; Lauren Averett Byers; Mark S Carey; Doris R Siwak; Maria Gabriela Raso; Lixia Diao; Jing Wang; Kevin R Coombes; Jack A Roth; Gordon B Mills; Ignacio I Wistuba; John D Minna; John V Heymach
Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(12):1894-904.
2010: Helena F Deus; Diogo F Veiga; Pablo R Freire; John N Weinstein; Gordon B Mills; Jonas Almeida
Exposing the cancer genome atlas as a SPARQL endpoint.
Journal of biomedical informatics 2010;43(6):998-1008.
2010: Ke Liang; Francisco J Esteva; Constance Albarracin; Katherine Stemke-Hale; Yang Lu; Giampaolo Bianchini; Ching-Yi Yang; Yong Li; Xinqun Li; Chun-Te Chen; Gordon B Mills; Gabriel N Hortobagyi; John Mendelsohn; Mien-Chie Hung; Zhen Fan
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
Cancer cell 2010;18(5):423-35.
2010: Xiaoyun Cheng; Weiya Xia; Jer-Yen Yang; Jennifer L Hsu; Jing-Yu Lang; Chao-Kai Chou; Yi Du; Hui-Lung Sun; Shannon L Wyszomierski; Gordon B Mills; William J Muller; Dihua Yu; Mien-Chie Hung
Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
Cancer research 2010;70(19):7684-9.
2010: Sergio Iadevaia; Yiling Lu; Fabiana C Morales; Gordon B Mills; Prahlad T Ram
Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.
Cancer research 2010;70(17):6704-14.
2010: Christopher I Amos; Ivan P Gorlov; Qiong Dong; Xifeng Wu; Huifeng Zhang; Emily Y Lu; Paul Scheet; Anthony Greisinger; Gordon B Mills; Margaret R Spitz
Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study.
Journal of the National Cancer Institute 2010;102(15):1199-205.
2010: Bryan T. J. Hennessy; Kirsten M Timms; Mark S Carey; Alexander Gutin; Larissa A Meyer; Darl D Flake; Victor Abkevich; Jennifer Potter; Dmitry Pruss; Pat Glenn; Yang Li; Jie Li; Ana M Gonzalez-Angulo; Karen Smith McCune; Maurie Markman; Russell R Broaddus; Jerry S Lanchbury; Karen H Lu; Gordon B Mills
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(22):3570-6.
2010: Gong Yang; Daniel G Rosen; Guangzhi Liu; Fan Yang; Xiaoqing Guo; Xue Xiao; Fengxia Xue; Imelda Mercado-Uribe; Jiaoti Huang; Sue-Hwa Lin; Gordon B Mills; Jinsong Liu
CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(15):3875-86.
2010: Gong Yang; Bin Chang; Fan Yang; Xiaoqing Guo; Kathy Qi Cai; Xue Sherry Xiao; Huamin Wang; Subrata Sen; Mien-Chie Hung; Gordon B Mills; Sandy Chang; Asha S Multani; Imelda Mercado-Uribe; Jinsong Liu
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3171-81.
2010: Ana M Gonzalez-Angulo; Bryan T. J. Hennessy; Gordon B Mills
Future of personalized medicine in oncology: a systems biology approach.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(16):2777-83.
2010: Mark S Carey; Roshan Agarwal; Blake Gilks; Kenneth Swenerton; Steve Kalloger; Jennifer Santos; Zhenlin Ju; Yiling Lu; Fan Zhang; Kevin R Coombes; Dianne Miller; David Huntsman; Gordon B Mills; Bryan T. J. Hennessy
Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(10):2852-60.
2010: Nattapon Panupinthu; H Y Lee; Gordon B Mills
Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.
British journal of cancer 2010;102(6):941-6.
2010: Gordon B Mills; Yosef Yarden
The rebirth of a phoenix: ovarian cancers are addicted to ErbB-3.
Cancer cell 2010;17(3):217-8.
2010: Eun Sung Park; Rosalia Rabinovsky; Mark Carey; Bryan T. J. Hennessy; Roshan Agarwal; Wenbin Liu; Zhenlin Ju; Wanleng Deng; Yiling Lu; hyun goo woo; Sang-Bae Kim; Jae-Ho Cheong; Levi A Garraway; John N Weinstein; Gordon B Mills; Ju-Seog Lee; Michael A Davies
Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set.
Molecular cancer therapeutics 2010;9(2):257-67.
2010: Chad J Creighton; Xiaoyong Fu; Bryan T Hennessy; Angelo J Casa; Yiqun Zhang; Ana Maria Gonzalez-Angulo; Ana Lluch; Joe Gray; Powel H Brown; Susan G Hilsenbeck; C Kent Osborne; Gordon B Mills; Adrian V Lee; Rachel Schiff
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
Breast cancer research : BCR 2010;12(3):R40.
2010: Zhiyong Ding; Jiyong Liang; Jin Li; Yiling Lu; Vathsala Ariyaratna; Zhimin Lu; Michael A Davies; John K Westwick; Gordon B Mills
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
PloS one 2010;5(3):e9910.
2010: Doris R Siwak; Mark Carey; Bryan T Hennessy; Catherine T Nguyen; Mollianne J McGahren Murray; Laura Nolden; Gordon B Mills
Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.
Journal of oncology 2010;2010():568938.
2010: Jingfang Zheng; Imelda Mercado-Uribe; Daniel G Rosen; Bin Chang; Peishu Liu; Gong Yang; Anais Malpica; Honami Noara; Nelly Auersperg; Gordon B Mills; Robert C Bast; Jinsong Liu
Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment.
Cell cycle (Georgetown, Tex.) 2010;9(1):140-6.
2009: Lauren Averett Byers; Banibrata Sen; Babita Saigal; Lixia Diao; Jing Wang; Meera Nanjundan; Tina Cascone; Gordon B Mills; John V Heymach; Faye M Johnson
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6852-61.
2009: Shuying Liu; Mandi Murph; Nattapon Panupinthu; Gordon B Mills
ATX-LPA receptor axis in inflammation and cancer.
Cell cycle (Georgetown, Tex.) 2009;8(22):3695-701.
2009: Roshan Agarwal; Igor Jurisica; Gordon B Mills; Kwai Wa Cheng
The emerging role of the RAB25 small GTPase in cancer.
Traffic (Copenhagen, Denmark) 2009;10(11):1561-8.
2009: Scott E Woodman; Jonathan Trent; Katherine Stemke-Hale; Alexander Lazar; Pricl Sabrina; Giovanni M Pavan; Maurizio Fermeglia; Y N Vashisht Gopal; Dan Yang; Donald A Podoloff; Doina Ivan; Kevin B Kim; Nicholas Papadopoulos; Patrick Hwu; Gordon B Mills; Michael A Davies
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Molecular cancer therapeutics 2009;8(8):2079-85.
2009: Gordon B Mills; Igor Jurisica; Yosef Yarden; Jim C Norman
Genomic amplicons target vesicle recycling in breast cancer.
The Journal of clinical investigation 2009;119(8):2123-7.
2009: Shuying Liu; Makiko Umezu-Goto; Mandi Murph; Yiling Lu; Wenbin Liu; Fan Zhang; Shuangxing Yu; L Clifton Stephens; Xiaojiang Cui; George Murrow; Kevin Coombes; William Muller; Mien-Chie Hung; Charles M Perou; Adrian V Lee; Xianjun Fang; Gordon B Mills
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2009: Roshan Agarwal; Ana M Gonzalez-Angulo; Simen Myhre; Mark Carey; Ju-Seog Lee; Jens Overgaard; Jan Alsner; Katherine Stemke-Hale; Ana Lluch; Richard M Neve; Wen Lin Kuo; Therese Sorlie; Aysegul Sahin; Vicente Valero; Khandan Keyomarsi; Joe Gray; Anne-Lise Borresen-Dale; Gordon B Mills; Bryan T. J. Hennessy
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3654-62.
2009: Robert C Bast; Bryan T. J. Hennessy; Gordon B Mills
The biology of ovarian cancer: new opportunities for translation.
Nature reviews. Cancer 2009;9(6):415-28.
2009: Bryan T. J. Hennessy; Ana M Gonzalez-Angulo; Katherine Stemke-Hale; Michael Z Gilcrease; Savitri Krishnamurthy; Ju-Seog Lee; Jane Fridlyand; Aysegul Sahin; Roshan Agarwal; Corwin Joy; Wenbin Liu; David N Stivers; Keith A Baggerly; Mark Carey; Ana Lluch; Carlos Monteagudo; Xiaping He; Victor Weigman; Cheng Fan; Juan Palazzo; Gabriel N Hortobagyi; Laura K Nolden; Nicholas J Wang; Vicente Valero; Joe Gray; Charles M Perou; Gordon B Mills
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Cancer research 2009;69(10):4116-24.
2009: Changye Y Zou; Kerrington D Smith; Quan-Sheng Zhu; Jun Liu; Ian E McCutcheon; John M Slopis; Funda Meric-Bernstam; Zhenghong Peng; William G Bornmann; Gordon B Mills; Alexander Lazar; Raphael E Pollock; Dina lev
Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
Molecular cancer therapeutics 2009;8(5):1157-68.
2009: Eun-Kyoung Yim; Guang Peng; Hui Dai; R Hu; Kaiyi Li; Yiling Lu; Gordon B Mills; Funda Meric-Bernstam; Bryan T. J. Hennessy; Rolf J Craven; Shiaw-Yih Lin
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Cancer cell 2009;15(4):304-14.
2009: Ana M Gonzalez-Angulo; Katherine Stemke-Hale; Shana L Palla; Mark Carey; Roshan Agarwal; Funda Meric-Berstam; Tiffany A Traina; Clifford Hudis; Gabriel N Hortobagyi; William L Gerald; Gordon B Mills; Bryan T. J. Hennessy
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2472-8.
2009: Dessislava A Nikolova; Irfan Asangani; Laura D Nelson; Dennis P M Hughes; Doris R Siwak; Gordon B Mills; Andrea Harms; Erika Buchholz; Lothar Richard Pilz; Christian Manegold; Heike Allgayer
Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
Cancer research 2009;69(6):2461-70.
2009: Zehra Pamuklar; Lorenzo Federico; Shuying Liu; Makiko Umezu-Goto; Anping Dong; Manikandan Panchatcharam; Zachary Fulkerson; Zachary Fulerson; Evgeny Berdyshev; Viswanathan Natarajan; Xianjun Fang; Laurens van Meeteren; Wouter H Moolenaar; Gordon B Mills; Andrew J Morris; Susan Smyth
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
The Journal of biological chemistry 2009;284(11):7385-94.
2009: Ralph G Zinner; Brittany L Barrett; Elmira Popova; Paul Damien; Andrei Y Volgin; Juri G Gelovani; Reuben Lotan; Hai T Tran; Claudio Pisano; Gordon B Mills; Li Mao; Waun Ki Hong; Scott M Lippman; John H Miller
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
Molecular cancer therapeutics 2009;8(3):521-32.
2009: Musaffe Tuna; Sakari Knuutila; Gordon B Mills
Uniparental disomy in cancer.
Trends in molecular medicine 2009;15(3):120-8.
2009: Li Zhang; Qingyi Wei; Li Mao; Wenbin Liu; Gordon B Mills; Kevin R Coombes
Serial dilution curve: a new method for analysis of reverse phase protein array data.
Bioinformatics (Oxford, England) 2009;25(5):650-4.
2009: Bryan T. J. Hennessy; Ana M Gonzalez-Angulo; Mark S Carey; Gordon B Mills
A systems approach to analysis of molecular complexity in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):417-9.
2009: Olga K Mirzoeva; Debopriya Das; Laura M Heiser; Sanchita Bhattacharya; Doris Siwak; Rina Gendelman; Nora Bayani; Nicholas J Wang; Richard M Neve; Yinghui Guan; Zhi Hu; Zachary A Knight; Heidi S Feiler; Philippe Gascard; Bahram Parvin; Paul Spellman; Kevan M Shokat; Andrew J Wyrobek; Mina J Bissell; Frank McCormick; Wen-Lin Kuo; Gordon B Mills; Joe Gray; W Michael Korn
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Cancer research 2009;69(2):565-72.
2009: Mandi Murph; Wenbin Liu; Shuangxing Yu; Yiling Lu; Hassan Hall; Bryan T. J. Hennessy; John Lahad; Marci Schaner; Aslaug Helland; Gunnar Kristensen; Anne-Lise Børresen-Dale; Gordon B Mills
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
PloS one 2009;4(5):e5583.
2009: Nathan T Ihle; Robert Lemos; Peter Wipf; Adly Yacoub; Clint Mitchell; Doris R Siwak; Gordon B Mills; Paul Dent; D Lynn Kirkpatrick; Garth Powis
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Cancer research 2009;69(1):143-50.
2009: Steven M Kornblau; Raoul Tibes; Yi Hua Qiu; Wenjing Chen; Hagop M Kantarjian; Michael Andreeff; Kevin R Coombes; Gordon B Mills
Functional proteomic profiling of AML predicts response and survival.
Blood 2009;113(1):154-64.
2008: Shuangxing Yu; Mandi Murph; Yiling Lu; Shuying Liu; Hassan S Hall; Jinsong Liu; Clifton Stephens; Xianjun Fang; Gordon B Mills
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Journal of the National Cancer Institute 2008;100(22):1630-42.
2008: Michael A Davies; Katherine Stemke-Hale; Carmen Tellez; T L Calderone; W Deng; Victor G Prieto; Alexander Lazar; jeffrey gershenwald; Gordon B Mills
A novel AKT3 mutation in melanoma tumours and cell lines.
British journal of cancer 2008;99(8):1265-8.
2008: Laura A Lambert; Na Qiao; Kelly K Hunt; Donald H Lambert; Gordon B Mills; Laurent Meijer; Khandan Keyomarsi
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
Cancer research 2008;68(19):7966-74.
2008: Tomohisa Yokoyama; Eiji Iwado; Yasuko Kondo; Hiroshi Aoki; Y Hayashi; Maria-Magdalena Georgescu; Raymond Sawaya; Kenneth R Hess; Gordon B Mills; H Kawamura; Y Hashimoto; Y Urata; T Fujiwara; Seiji Kondo
Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Gene therapy 2008;15(17):1233-9.
2008: Mandi Murph; Giang H Nguyen; Harish Radhakrishna; Gordon B Mills
Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.
Biochimica et biophysica acta 2008;1781(9):547-57.
2008: Yongkun Wei; Weiya Xia; Zhihong Zhang; Jinsong Liu; Huamin Wang; Nazmi V Adsay; Constance Albarracin; Dihua Yu; James L Abbruzzese; Gordon B Mills; Robert C Bast; Gabriel N Hortobagyi; Mien-Chie Hung
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Meera Nanjundan; Kwai Wa Cheng; Fan Zhang; John P Lahad; Wen-Lin Kuo; Rosemarie Schmandt; Karen Smith-McCune; David Fishman; Joe Gray; Gordon B Mills
Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
Molecular oncology 2008;2(2):164-81.
2008: Katherine Stemke-Hale; Ana Maria Gonzalez-Angulo; Ana Lluch; Richard M Neve; Wen-Lin Kuo; Michael Davies; Mark Carey; Zhi Hu; Yinghui Guan; Aysegul Sahin; W Fraser Symmans; Lajos Pusztai; Laura K Nolden; Hugo Horlings; Katrien Berns; Mien-Chie Hung; Marc J van de Vijver; Vicente Valero; Joe Gray; René Bernards; Gordon B Mills; Bryan T. J. Hennessy
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2008: Tobias Grote; Doris R Siwak; Herbert A Fritsche; Corwin Joy; Gordon B Mills; Diane M Simeone; david whitcomb; Craig D Logsdon
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer.
Proteomics 2008;8(15):3051-60.
2008: Yutaka Hasegawa; Mandi Murph; Shuangxing Yu; Gabor Tigyi; Gordon B Mills
Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Molecular oncology 2008;2(1):54-69.
2008: Melissa Muller; Mandri Obeyesekere; Gordon B Mills; Prahlad T Ram
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1393-403.
2008: Shuying Liu; Xianjun Fang; Hassan Hall; Shuangxing Yu; Debra Smith; Zhimin Lu; Dexing Fang; Jinsong Liu; L Clifton Stephens; James R Woodgett; Gordon B Mills
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
2008: Yuan Ji; Yiling Lu; Gordon B Mills
Bayesian models based on test statistics for multiple hypothesis testing problems.
Bioinformatics (Oxford, England) 2008;24(7):943-9.
2008: Jer-Yen Yang; Cong S Zong; Weiya Xia; Hirohito Yamaguchi; Qingqing Ding; Xiaoming Xie; Jing-Yu Lang; Chien-Chen Lai; Chun-Ju Chang; Huang Wei-Chien; Hsin Huang; Hsu-Ping Kuo; Dung-Fang Lee; Long-Yuan Li; Huang-Chun Lien; Xiaoyun Cheng; King-Jen Chang; Chwan-Deng Hsiao; Fuu-Jen Tsai; Chang-Hai Tsai; Aysegul A Sahin; William J Muller; Gordon B Mills; Dihua Yu; Gabriel N Hortobagyi; Mien-Chie Hung
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Nature cell biology 2008;10(2):138-48.
2008: Pablo Freire; Marco Vilela; Helena Deus; Yong-Wan Kim; Dimpy Koul; Howard Colman; Kenneth Aldape; Oliver Bogler; W K Alfred Yung; Kevin R Coombes; Gordon B Mills; Ana T Vasconcelos; Jonas Almeida
Exploratory analysis of the copy number alterations in glioblastoma multiforme.
PloS one 2008;3(12):e4076.
2008: Romesh Stanislaus; Mark Carey; Helena Deus; Kevin R Coombes; Bryan T. J. Hennessy; Gordon B Mills; Jonas Almeida
RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays.
BMC bioinformatics 2008;9():555.
2008: Bryan T. J. Hennessy; Mandi Murph; Meera Nanjundan; Mark Carey; Nelly Auersperg; Jonas Almeida; Kevin R Coombes; Jinsong Liu; Yiling Lu; Joe Gray; Gordon B Mills
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Advances in experimental medicine and biology 2008;617():23-40.
2007: Joanna Gajewiak; Ryoko Tsukahara; Tamotsu Tsukahara; Yuko Fujiwara; Shuanxing Yu; Yiling Lu; Mandi Murph; Gordon B Mills; Gabor Tigyi; Glenn D Prestwich
Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
ChemMedChem 2007;2(12):1789-98.
2007: Zhi-Xiang Xu; Jiyong Liang; Valsala Haridas; Amos Gaikwad; F P Connolly; Gordon B Mills; Jordan U Gutterman
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Cell death and differentiation 2007;14(11):1948-57.
2007: Katrien Berns; Hugo Horlings; Bryan T. J. Hennessy; Mandy Madiredjo; E Marielle Hijmans; Karin Beelen; Sabine C Linn; Ana M Gonzalez-Angulo; Katherine Stemke-Hale; Michael Hauptmann; Roderick L Beijersbergen; Gordon B Mills; Marc J van de Vijver; René Bernards
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Cancer cell 2007;12(4):395-402.
2007: Chien-Hsing Lu; Shannon L Wyszomierski; Ling-Ming Tseng; Meng-hong Sun; Keng-Hsueh Lan; Christopher L Neal; Gordon B Mills; Gabriel N Hortobagyi; Francisco J Esteva; Dihua Yu
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5883-8.
2007: Yinghui Guan; Wen-Lin Kuo; Jackie L Stilwell; Hirokuni Takano; Anna Lapuk; Jane Fridlyand; Jian-Hua Mao; Mamie Yu; Melinda A Miller; Jennifer L Santos; Steve Kalloger; Joseph W Carlson; David Ginzinger; Susan E Celniker; Gordon B Mills; David Huntsman; Joe Gray
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5745-55.
2007: Keishi Fujiwara; Eiji Iwado; Gordon B Mills; Raymond Sawaya; Seiji Kondo; Yasuko Kondo
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
International journal of oncology 2007;31(4):753-60.
2007: Yang Lu; Xinqun Li; Ke Liang; Rodney B Luwor; Zahid H Siddik; Gordon B Mills; John Mendelsohn; Zhen Fan
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
Cancer research 2007;67(17):8240-7.
2007: Hiroshi Aoki; Eiji Iwado; Mark S Eller; Yasuko Kondo; Keishi Fujiwara; Guang-Zhi Li; Kenneth R Hess; Doris R Siwak; Raymond Sawaya; Gordon B Mills; Barbara A Gilchrest; Seiji Kondo
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2918-30.
2007: Veronica C Estrella; Astrid Eder; Shuying Liu; Terri B Pustilnik; Fazal H Tabassam; Francois Claret; Gary E Gallick; Gordon B Mills; Jon R Wiener
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
International journal of oncology 2007;31(2):441-9.
2007: Fumiyuki Yamasaki; Mary J Johansen; Dongwei Zhang; Savitri Krishnamurthy; Edward Felix; Chandra Bartholomeusz; Richard J Aguilar; Kaoru Kurisu; Gordon B Mills; Gabriel N Hortobagyi; Naoto T Ueno
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Cancer research 2007;67(12):5779-88.
2007: Meera Nanjundan; F Zhang; R Schmandt; Karen Smith-McCune; Gordon B Mills
Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
Oncogene 2007;26(18):2574-84.
2007: Dexing Fang; David Hawke; Yanhua Zheng; Yan Xia; Jill Meisenhelder; Heinz Nika; Gordon B Mills; Ryuji Kobayashi; Tony Hunter; Zhimin Lu
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
The Journal of biological chemistry 2007;282(15):11221-9.
2007: Qing Zhang; Neil E Bhola; Vivian Wai Yan Lui; Doris R Siwak; Sufi Thomas; Christopher T Gubish; Jill M Siegfried; Gordon B Mills; Dong M Shin; Jennifer Rubin Grandis
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Molecular cancer therapeutics 2007;6(4):1414-24.
2007: Meera Nanjundan; Yasuhisa Nakayama; Kwai Wa Cheng; John P Lahad; Jinsong Liu; Karen Lu; Wen-Lin Kuo; Karen Smith-McCune; David Fishman; Joe Gray; Gordon B Mills
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Cancer research 2007;67(7):3074-84.
2007: Arifumi Iwamaru; Yasuko Kondo; Eiji Iwado; Hiroshi Aoki; Keishi Fujiwara; Tomohisa Yokoyama; Gordon B Mills; Seiji Kondo
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Oncogene 2007;26(13):1840-51.
2007: Jiyong Liang; Shan H Shao; Zhi-Xiang Xu; Bryan T. J. Hennessy; Zhiyong Ding; Michelle Larrea; Seiji Kondo; Dan J Dumont; Jordan U Gutterman; Cheryl Lyn Walker; Joyce M Slingerland; Gordon B Mills
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Nature cell biology 2007;9(2):218-24.
2007: Yoko Tabe; Linhua Jin; Yuko Tsutsumi-Ishii; Yuanyuan Xu; Teresa McQueen; Waldemar Priebe; Gordon B Mills; Akimichi Ohsaka; Isao Nagaoka; Michael Andreeff; Marina Konopleva
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Cancer research 2007;67(2):684-94.
2007: Mandi Murph; Gordon B Mills
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Expert reviews in molecular medicine 2007;9(28):1-18.
2007: Robert C Bast; Molly Brewer; Changping Zou; Mary A Hernandez; Mary Daley; Robert F Ozols; Karen Lu; Zhen Lu; Donna Badgwell; Gordon B Mills; Steven J Skates; Zhen Zhang; Dan Chan; Anna Lokshin; Yinhua Yu
Prevention and early detection of ovarian cancer: mission impossible?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():91-100.
2007: Maher N Younes; Orhan G Yigitbasi; Yasemin D Yazici; Samar A Jasser; Cora D Bucana; Adel K El-Naggar; Gordon B Mills; Jeffrey N Myers
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Archives of otolaryngology--head & neck surgery 2007;133(1):15-23.
2007: Gong Yang; Daniel G Rosen; Imelda Mercado-Uribe; Justin A Colacino; Gordon B Mills; Robert C Bast; Chenyi Zhou; Jinsong Liu
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Carcinogenesis 2007;28(1):174-82.
2006: Mandi Murph; Tamotsu Tanaka; Shuying Liu; Gordon B Mills
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6598-602.
2006: Katherine Stemke-Hale; Bryan T. J. Hennessy; Gordon B Mills; Rahul Mitra
Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein.
Current oncology reports 2006;8(6):484-91.
2006: Gong Yang; Daniel G Rosen; Zhihong Zhang; Robert C Bast; Gordon B Mills; Justin A Colacino; Imelda Mercado-Uribe; Jinsong Liu
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16472-7.
2006: Zhiyong Ding; Jiyong Liang; Yiling Lu; Qinghua Yu; Zhou Songyang; Shiaw-Yih Lin; Gordon B Mills
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15014-9.
2006: Raoul Tibes; Yihua Qiu; Yiling Lu; Bryan T. J. Hennessy; Michael Andreeff; Gordon B Mills; Steven M Kornblau
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Molecular cancer therapeutics 2006;5(10):2512-21.
2006: Daniel L Baker; Yuko Fujiwara; Kathryn R Pigg; Ryoko Tsukahara; Susumu Kobayashi; Hiromu Murofushi; Ayako Uchiyama; Kimiko Murakami-Murofushi; Eunjin Koh; Russell W Bandle; Hoe-Sup Byun; Robert Bittman; Dominic Fan; Mandi Murph; Gordon B Mills; Gabor Tigyi
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
The Journal of biological chemistry 2006;281(32):22786-93.
2006: Rekha Rai; Hui Dai; Asha S Multani; Kaiyi Li; Koei Chin; Joe Gray; John P Lahad; Jiyong Liang; Gordon B Mills; Funda Meric-Bernstam; Shiaw-Yih Lin
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Cancer cell 2006;10(2):145-57.
2006: Xinqun Li; Yang Lu; Weidong Jin; Ke Liang; Gordon B Mills; Zhen Fan
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
The Journal of biological chemistry 2006;281(19):13837-43.
2006: Qing Zhang; Sufi Thomas; Vivian Wai Yan Lui; Sichuan Xi; Jill M Siegfried; Huizhou Fan; Thomas E Smithgall; Gordon B Mills; Jennifer Rubin Grandis
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6901-6.
2006: Daniel G Rosen; Gong Yang; Michael T Deavers; Anais Malpica; John J Kavanagh; Gordon B Mills; Jinsong Liu
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.
Cancer 2006;106(9):1925-32.
2006: Zhihong Zeng; Ismael Samudio; Weiguo Zhang; Zeev Estrov; Helene Pelicano; David Harris; Olga Frolova; Numsen Hail; Wenjing Chen; Steven M Kornblau; Peng Huang; Yiling Lu; Gordon B Mills; Michael Andreeff; Marina Konopleva
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Cancer research 2006;66(7):3737-46.
2006: Mahitosh Mandal; Maher N Younes; Eric A Swan; Samar A Jasser; Dao Doan; Orhan G Yigitbasi; Andrea McMurphey; James Ludwick; Adel K El-Naggar; Corazon D Bucana; Gordon B Mills; Jeffrey N Myers
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Oral oncology 2006;42(4):430-9.
2006: Bryan T. J. Hennessy; Meera Nanjundan; Kwai Wa Cheng; Laura Nolden; Gordon B Mills
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
European journal of human genetics : EJHG 2006;14(4):381-3.
2006: Lian Qian; Yong Xu; Ted Simper; Guowei Jiang; Junken Aoki; Makiko Umezu-Goto; Hiroyuki Arai; Shuangxing Yu; Gordon B Mills; Ryoko Tsukahara; Natalia Makarova; Yuko Fujiwara; Gabor Tigyi; Glenn D Prestwich
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
2006: Dimpy Koul; Ruijun Shen; Sherry Bergh; Xiaoyang Sheng; Shishir Shishodia; Tiffany A Lafortune; Yiling Lu; John F de Groot; Gordon B Mills; W K Alfred Yung
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Molecular cancer therapeutics 2006;5(3):637-44.
2006: Quan-Sheng Zhu; Ling Xia; Gordon B Mills; Clifford A Lowell; Ivo P Touw; Seth J Corey
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
Blood 2006;107(5):1847-56.
2006: Georgios V Georgakis; Yang Li; George Z Rassidakis; L Jeffrey Medeiros; Gordon B Mills; Anas Younes
Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
British journal of haematology 2006;132(4):503-11.
2006: Carlos H Barcenas; G M Monawar Hosain; Banu Arun; Jihong Zong; Xiaojun Zhou; Jianfang Chen; Jill M Cortada; Gordon B Mills; Gail Tomlinson; Alexander R Miller; Louise C Strong; Christopher I Amos
Assessing BRCA carrier probabilities in extended families.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(3):354-60.
2006: Bryan T. J. Hennessy; Gordon B Mills
Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling.
The international journal of biochemistry & cell biology 2006;38(9):1450-6.
2005: Bryan T. J. Hennessy; Debra L Smith; Prahlad T Ram; Yiling Lu; Gordon B Mills
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Nature reviews. Drug discovery 2005;4(12):988-1004.
2005: Dimpy Koul; Ruijun Shen; Sherry Bergh; Yiling Lu; John F de Groot; Ta-Jen Liu; Gordon B Mills; W K Alfred Yung
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Molecular cancer therapeutics 2005;4(11):1681-8.
2005: Rebecca T Marquez; Keith A Baggerly; Andrea P Patterson; Jinsong Liu; Russell R Broaddus; Michael Frumovitz; E Neely Atkinson; David I Smith; Lynn Hartmann; David Fishman; Andrew Berchuck; Regina Whitaker; David M Gershenson; Gordon B Mills; Robert C Bast; Karen H Lu
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6116-26.
2005: Astrid Eder; Xiaomei Sui; Daniel G Rosen; Laura K Nolden; Kwai Wa Cheng; John P Lahad; Madhuri Kango-Singh; Karen H Lu; Carla L Warneke; E Neely Atkinson; Isabelle Bedrosian; Khandan Keyomarsi; Wen-Lin Kuo; Joe Gray; Jerry C P Yin; Jinsong Liu; Georg Halder; Gordon B Mills
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12519-24.
2005: Maher N Younes; Seungwon Kim; Orhan G Yigitbasi; Mahitosh Mandal; Samar A Jasser; Yasemin Dakak Yazici; Bradley Schiff; Adel El-Naggar; B Nebiyou Bekele; Gordon B Mills; Jeffrey N Myers
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Molecular cancer therapeutics 2005;4(8):1146-56.
2005: Arata Nishimoto; Yinhua Yu; Zhen Lu; Xiang Mao; Zhiyong Ren; Stephanie S Watowich; Gordon B Mills; Warren S-L Liao; Xiaomin Chen; Robert C Bast; Robert Z Luo
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Cancer research 2005;65(15):6701-10.
2005: Zhensheng Liu; Li-E Wang; Luo Wang; Karen H Lu; Gordon B Mills; Melissa L Bondy; Qingyi Wei
Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4968-76.
2005: John P Lahad; Gordon B Mills; Kevin R Coombes
Stem cell-ness: a "magic marker" for cancer.
The Journal of clinical investigation 2005;115(6):1463-7.
2005: Mahitosh Mandal; S Kim; Maher N Younes; Samar A Jasser; Adel K El-Naggar; Gordon B Mills; Jeffrey N Myers
The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
British journal of cancer 2005;92(10):1899-905.
2005: Yong Xu; Junken Aoki; Kumiko Shimizu; Makiko Umezu-Goto; Kotaro Hama; Yasukazu Takanezawa; Shuangxing Yu; Gordon B Mills; Hiroyuki Arai; Lian Qian; Glenn D Prestwich
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
2005: Hayato Takeuchi; Yasuko Kondo; Keishi Fujiwara; Takao Kanzawa; Hiroshi Aoki; Gordon B Mills; Seiji Kondo
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Cancer research 2005;65(8):3336-46.
2005: Kwai Wa Cheng; John P Lahad; Joe Gray; Gordon B Mills
Emerging role of RAB GTPases in cancer and human disease.
Cancer research 2005;65(7):2516-9.
2005: Katherine M Sheehan; Valerie S Calvert; Elaine W Kay; Yiling Lu; David Fishman; Virginia Espina; Joy Aquino; Runa Speer; Robyn Araujo; Gordon B Mills; Lance A Liotta; Emanuel F Petricoin; Julia D Wulfkuhle
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
Molecular & cellular proteomics : MCP 2005;4(4):346-55.
2005: Jinjiang Dong; Junying Peng; Haixia Zhang; Wallace H Mondesire; Weiguo Jian; Gordon B Mills; Mien-Chie Hung; Funda Meric-Bernstam
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 2005;65(5):1961-72.
2005: Xiao-Feng Le; Amy Lammayot; David Gold; Yiling Lu; Weiqun Mao; Teresa Chang; Adarsh Patel; Gordon B Mills; Robert C Bast
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
The Journal of biological chemistry 2005;280(3):2092-104.
2004: Shuying Liu; Shuangxing Yu; Yutaka Hasegawa; Ruth Lapushin; Hong-Ji Xu; James R Woodgett; Gordon B Mills; Xianjun Fang
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
2004: Funda Meric-Bernstam; Gordon B Mills
Mammalian target of rapamycin.
Seminars in oncology 2004;31(6 Suppl 16):10-7; discussion 33.
2004: Kwai Wa Cheng; John P Lahad; Wen-Lin Kuo; Anna Lapuk; Kyosuke Yamada; Nelly Auersperg; Jinsong Liu; Karen Smith-McCune; Karen H Lu; David Fishman; Joe Gray; Gordon B Mills
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Nature medicine 2004;10(11):1251-6.
2004: Wallace H Mondesire; Weiguo Jian; Haixia Zhang; Joe Ensor; Mien-Chie Hung; Gordon B Mills; Funda Meric-Bernstam
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7031-42.
2004: Makiko Umezu-Goto; Janos L Tanyi; John Lahad; Shuying Liu; Shuangxing Yu; Ruth Lapushin; Yutaka Hasegawa; Yiling Lu; Rosanne Trost; Therese Bevers; Eric Jonasch; Kenneth Aldape; Jinsong Liu; Robyn D James; Colin G Ferguson; Yong Xu; Glenn D Prestwich; Gordon B Mills
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
2004: Karen H Lu; Andrea P Patterson; Lin Wang; Rebecca T Marquez; E Neely Atkinson; Keith A Baggerly; Lance R Ramoth; Daniel G Rosen; Jinsong Liu; Ingegerd Hellstrom; David Smith; Lynn Hartmann; David Fishman; Andrew Berchuck; Rosemarie Schmandt; Regina Whitaker; David M Gershenson; Gordon B Mills; Robert C Bast
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3291-300.
2004: Shankar Sellappan; Rebecca Grijalva; Xiaoyan Zhou; Wentao Yang; Menashe Bar Eli; Gordon B Mills; Dihua Yu
Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line.
Cancer research 2004;64(10):3479-85.
2004: Kwai Wa Cheng; John P Lahad; Gordon B Mills
Analysis of molecular aberrations in ovarian cancer allows novel target identification.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC 2004;26(5):461-74.
2004: Xianjun Fang; Shuangxing Yu; Robert C Bast; Shuying Liu; Hong-Ji Xu; Shi-Xue Hu; Ruth Lapushin; Francois Claret; Bharat B Aggarwal; Yiling Lu; Gordon B Mills
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2004: Jinsong Liu; Gong Yang; Jennifer A Thompson-Lanza; Armand B. Glassman; Kimberly Hayes; Andrea Patterson; Rebecca T Marquez; Nelly Auersperg; Yinhua Yu; William C Hahn; Gordon B Mills; Robert C Bast
A genetically defined model for human ovarian cancer.
Cancer research 2004;64(5):1655-63.
2004: Elise C Kohn; Yiling Lu; Hongwei Wang; Qinghua Yu; Shuangxing Yu; Hassan Hall; Debra L Smith; Funda Meric-Bernstam; Gabriel N Hortobagyi; Gordon B Mills
Molecular therapeutics: promise and challenges.
Seminars in oncology 2004;31(1 Suppl 3):39-53.
2004: Woo-Chul Noh; Wallace H Mondesire; Junying Peng; Weiguo Jian; Haixia Zhang; JinJiang Dong; Gordon B Mills; Mien-Chie Hung; Funda Meric-Bernstam
Determinants of rapamycin sensitivity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1013-23.
2004: Shourong Zhao; Marina Konopleva; Maria Cabreira; Z Xie; Wei Hu; Michele Milella; Zeev Estrov; Gordon B Mills; Michael Andreeff
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Leukemia 2004;18(2):267-75.
2004: Michael Andreeff; Michele Milella; Bing Z Carter; Yoko Tabe; Maria R Ricciardi; Thomas B Sneed; Peter P Ruvolo; Rooha Contractor; Twee Tsao; Wendy D Schober; Randall Evans; Teresa McQueen; Zhihong Zeng; Steven M Kornblau; James A McCubrey; Elihu Estey; Gordon B Mills; John C Reed; Marina Konopleva
Targeted therapy of AML new concepts.
Annals of hematology 2004;83 Suppl 1():S51-3.
2003: Lian Qian; Yong Xu; Yutaka Hasegawa; Junken Aoki; Gordon B Mills; Glenn D Prestwich
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Journal of medicinal chemistry 2003;46(26):5575-8.
2003: Yiling Lu; Qinghua Yu; Jue Hui Liu; Jinyi Zhang; Hongwei Wang; Dimpy Koul; John S McMurray; Xianjun Fang; W K Alfred Yung; Katherine A Siminovitch; Gordon B Mills
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
The Journal of biological chemistry 2003;278(41):40057-66.
2003: Gordon B Mills; Elise C Kohn; Yiling Lu; Astrid Eder; Xianjun Fang; Hongwei Wang; Robert C Bast; Joe Gray; Robert Jaffe; Gabriel Hortobagyi
Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):93-104.
2003: Janos L Tanyi; Yutaka Hasegawa; Ruth Lapushin; Andrew J Morris; Judith K Wolf; Andrew Berchuck; Karen Lu; David I Smith; Kimberly R Kalli; Lynn C Hartmann; Karen McCune; David Fishman; Russell R Broaddus; Kwai Wa Cheng; E Neely Atkinson; Jose-Miguel Yamal; Robert C Bast; Edward Felix; Robert A Newman; Gordon B Mills
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3534-45.
2003: Timothy Clair; Junken Aoki; Eunjin Koh; Russell W Bandle; Suk Woo Nam; Malgorzata M Ptaszynska; Gordon B Mills; Elliott Schiffmann; Lance A Liotta; Mary L Stracke
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer research 2003;63(17):5446-53.
2003: Shi-Xue Hu; S Wang; J P Wang; Gordon B Mills; Y Zhou; Hong-Ji Xu
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
British journal of cancer 2003;89(1):135-9.
2003: Hyun S Shvartsman; Karen H Lu; John Lee; Jim Lillie; Michael T Deavers; Stephanie Clifford; Judith K Wolf; Gordon B Mills; Robert C Bast; David M Gershenson; Rosemarie Schmandt
Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
Gynecologic oncology 2003;90(1):44-50.
2003: Ho-Young Lee; Harish Srinivas; Dianren Xia; Yiling Lu; Robert Superty; Ruth Lapushin; Candelaria Gomez-Manzano; Anna Maria Gal; Garrett L Walsh; Thomas Force; Kohjiro Ueki; Gordon B Mills; Jonathan M Kurie
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
The Journal of biological chemistry 2003;278(26):23630-8.
2003: Yiling Lu; Hongwei Wang; Gordon B Mills
Targeting PI3K-AKT pathway for cancer therapy.
Reviews in clinical and experimental hematology 2003;7(2):205-28.
2003: Abdellah Mansouri; Lon D Ridgway; Anita L Korapati; Qingxiu Zhang; Ling Tian; Yibin Wang; Zahid H Siddik; Gordon B Mills; Francois Claret
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
The Journal of biological chemistry 2003;278(21):19245-56.
2003: Christiane Knuefermann; Yang Lu; Bolin Liu; Weidong Jin; Ke Liang; Ling Wu; Mathias Schmidt; Gordon B Mills; John Mendelsohn; Zhen Fan
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Oncogene 2003;22(21):3205-12.
2003: Robert Z Luo; Xianjun Fang; Rebecca T Marquez; Shu-Ying Liu; Gordon B Mills; Warren S-L Liao; Yinhua Yu; Robert C Bast
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Oncogene 2003;22(19):2897-909.
2003: Yutaka Hasegawa; James R Erickson; Graham J Goddard; Shuangxing Yu; Shuying Liu; Kwai Wa Cheng; Astrid Eder; Koji Bandoh; Junken Aoki; Renata Jarosz; Andrew D Schrier; Kevin R Lynch; Gordon B Mills; Xianjun Fang
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
2003: Ke Liang; Weidong Jin; Christiane Knuefermann; Mathias Schmidt; Gordon B Mills; K. Kian Ang; Luka Milas; Zhen Fan
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Molecular cancer therapeutics 2003;2(4):353-60.
2003: Xiaojiang Cui; Ping Zhang; Wanleng Deng; Steffi Oesterreich; Yiling Lu; Gordon B Mills; Adrian V Lee
Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):575-88.
2003: Janos L Tanyi; Andrew J Morris; Judith K Wolf; Xianjun Fang; Yutaka Hasegawa; Ruth Lapushin; Nelly Auersperg; Yury J Sigal; Robert A Newman; Edward Felix; E Neely Atkinson; Gordon B Mills
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
2003: Ugur Aytac; Kazuya Sato; Tadanori Yamochi; T Yamochi; Kei Ohnuma; Gordon B Mills; Chikao Morimoto; Nam H Dang
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
British journal of cancer 2003;88(3):455-62.
2003: Xiao-Feng Le; Walter N Hittelman; Jiaxin Liu; Amanda McWatters; Chun Li; Gordon B Mills; Robert C Bast
Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.
Oncogene 2003;22(4):484-97.
2003: Gordon B Mills; Xianjun Fang; Yiling Lu; Yutaka Hasegawa; Astrid Eder; Janos L Tanyi; Fazal H Tabassam; Muling Mao; Hongwei Wang; Kwai Wa Cheng; Yasuhisa Nakayama; Wenlin Kuo; Jim Erickson; David M Gershenson; Elise C Kohn; Robert Jaffe; Robert C Bast; Joe Gray
Specific keynote: molecular therapeutics in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S88-92; discussion S93-6.
2003: Robert C Bast; Gordon B Mills
General keynote: molecular therapeutics and pharmocogenomics.
Gynecologic oncology 2003;88(1 Pt 2):S84-7; discussion S93-6.
2003: Lance A Liotta; Emanuel F Petricoin; Ali Ardekani; Ben A Hitt; Peter J Levine; Vincent A Fusaro; Seth M Steinberg; Gordon B Mills; Charles Simone; David A Fishman; Elise C Kohn
General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S25-8; discussion S37-42.
2003: Joe Gray; Seiji Suzuki; Wen-Lin Kuo; Daniel Polikoff; Michael Deavers; Karen Smith-McCune; Andrew Berchuck; Daniel Pinkel; Donna G Albertson; Gordon B Mills
Specific keynote: genome copy number abnormalities in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S16-21; discussion S22-4.
2003: Jon R Wiener; T Christopher Windham; Veronica C Estrella; Nila U Parikh; Peter F Thall; Michael T Deavers; Robert C Bast; Gordon B Mills; Gary E Gallick
Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.
Gynecologic oncology 2003;88(1):73-9.
2002: Victor M Bondar; Bridget Sweeney-Gotsch; Michael Andreeff; Gordon B Mills; David J McConkey
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Molecular cancer therapeutics 2002;1(12):989-97.
2002: Makiko Umezu-Goto; Yasuhiro Kishi; Akitsu Taira; Kotaro Hama; Naoshi Dohmae; Koji Takio; Takao Yamori; Gordon B Mills; Keizo Inoue; Junken Aoki; Hiroyuki Arai
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
2002: Janos L Tanyi; Ruth Lapushin; Astrid Eder; Nelly Auersperg; Fazal H Tabassam; Jack A Roth; Jian Gu; Bingliang Fang; Gordon B Mills; Judith Wolf
Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Gynecologic oncology 2002;85(3):451-8.
2002: Xianjun Fang; Michel Schummer; Muling Mao; Shuangxing Yu; Fazal H Tabassam; Ramona Swaby; Yutaka Hasegawa; Janos L Tanyi; Ruth Lapushin; Astrid Eder; Robert Jaffe; Jim Erickson; Gordon B Mills
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
2002: Dimpy Koul; Samar A Jasser; Yiling Lu; Michael A Davies; Ruijun Shen; Yuexi Shi; Gordon B Mills; W K Alfred Yung
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Oncogene 2002;21(15):2357-64.
2002: Xianjun Fang; Shuangxing Yu; Janos L Tanyi; Yiling Lu; James R Woodgett; Gordon B Mills
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology 2002;22(7):2099-110.
2002: M Tien Kuo; Zesheng Liu; Yingjie Wei; Yen-Chiu Lin-Lee; Shigeru Tatebe; Gordon B Mills; Hitoshi Unate
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.
Oncogene 2002;21(13):1945-54.
2002: Emanuel F Petricoin; Ali Ardekani; Ben A Hitt; Peter J Levine; Vincent A Fusaro; Seth M Steinberg; Gordon B Mills; Charles Simone; David A Fishman; Elise C Kohn; Lance A Liotta
Use of proteomic patterns in serum to identify ovarian cancer.
Lancet 2002;359(9306):572-7.
2002: Thomas Buchholz; Xifeng Wu; Abu Hussain; Susan L Tucker; Gordon B Mills; Bruce G Haffty; Sherry Bergh; Michael D Story; Fady B Geara; William A Brock
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
International journal of cancer. Journal international du cancer 2002;97(5):557-61.
2002: Gordon B Mills; Astrid Eder; Xianjun Fang; Yutaka Hasegawa; Muling Mao; Yiling Lu; Janos L Tanyi; Fazal H Tabassam; Jon R Wiener; Ruth Lapushin; Shiangxing Yu; Jeff A Parrott; Tim Compton; Walter Tribley; David Fishman; M Sharon Stack; Douglas Gaudette; Robert Jaffe; Tatsuro Furui; Junken Aoki; James R Erickson
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
2001: Xiao-Feng Le; Marco Marcelli; Amanda McWatters; Bicheng Nan; Gordon B Mills; Catherine A O'Brian; Robert C Bast
Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Oncogene 2001;20(57):8258-69.
2001: Yong Zhu; Margaret R Spitz; L Lei; Gordon B Mills; Xifeng Wu
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility.
Cancer research 2001;61(21):7825-9.
2001: Gordon B Mills; Ying Lu; Xiang Fang; Hua Wang; Astrid Eder; Muling Mao; R Swaby; Kwai Wa Cheng; David Stokoe; Katherine A Siminovitch; Robert Jaffe; Joe Gray
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology 2001;28(5 Suppl 16):125-41.
2001: Ugur Aytac; Francois Claret; Linus Ho; Kazuya Sato; Kei Ohnuma; Gordon B Mills; Fernando Cabanillas; Chikao Morimoto; Nam H Dang
Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint.
Cancer research 2001;61(19):7204-10.
2001: Gordon B Mills; Yiling Lu; E C Kohn
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10031-3.
2001: Viji Shridhar; John Lee; Ajay Pandita; Stephen J Iturria; Rajeswari Avula; Julie Staub; M Morrissey; E Calhoun; A Sen; Kimberly R Kalli; Gary L Keeney; P Roche; William A Cliby; K Lu; Rosemarie Schmandt; Gordon B Mills; Robert C Bast; C David James; Fergus J. Couch; Lynn C Hartmann; Jim Lillie; David I Smith
Genetic analysis of early- versus late-stage ovarian tumors.
Cancer research 2001;61(15):5895-904.
2001: Bolin Liu; M Fang; Yang Lu; Y Lu; Gordon B Mills; Zhen Fan
Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
British journal of cancer 2001;85(2):303-11.
2001: Bruce D Cuevas; Ying Lu; Muling Mao; Jinyi Zhang; Ruth Lapushin; Katherine A Siminovitch; Gordon B Mills
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(29):27455-61.
2001: Kalpana Mujoo; Valsala Haridas; JJ Hoffmann; Gerald A Wächter; L K Hutter; Ying Lu; ME Blake; Gamini S Jayatilake; D Bailey; Gordon B Mills; Jordan U Gutterman
Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
Cancer research 2001;61(14):5486-90.
2001: Linus Ho; Ugur Aytac; L Clifton Stephens; Kei Ohnuma; Gordon B Mills; Kathryn S McKee; C Neumann; Ruth Lapushin; Fernando Cabanillas; James L Abbruzzese; Chikao Morimoto; Nam H Dang
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2031-40.
2001: James R Erickson; Yutaka Hasegawa; Xiang Fang; Astrid Eder; Muling Mao; Tatsuro Furui; Junken Aoki; Andrew J Morris; Gordon B Mills
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
2000: RP Kruzelock; Bruce D Cuevas; Jon R Wiener; FJ Xu; Y Yu; Y Cabeza-Arvelaiz; MA Pershouse; M M Lovell; A M Killary; Gordon B Mills; Robert C Bast
Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
Oncogene 2000;19(54):6277-85.
2000: Muling Mao; Xiang Fang; Ying Lu; Ruth Lapushin; Robert C Bast; Gordon B Mills
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
The Biochemical journal 2000;352 Pt 2():475-82.
2000: Xiang Fang; Shiangxing Yu; Ruth Lapushin; Ying Lu; Tatsuro Furui; L Z Penn; David Stokoe; James R Erickson; Robert C Bast; Gordon B Mills
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
The Biochemical journal 2000;352 Pt 1():135-43.
2000: Xiang Fang; S X Yu; Yiling Lu; Robert C Bast; James R Woodgett; Gordon B Mills
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11960-5.
2000: Xiao-Feng Le; Ratna K Vadlamudi; Amanda McWatters; D S Bae; Gordon B Mills; Rakesh Kumar; Robert C Bast
Differential signaling by an anti-p185(HER2) antibody and heregulin.
Cancer research 2000;60(13):3522-31.
2000: Astrid Eder; T Sasagawa; Muling Mao; Junken Aoki; Gordon B Mills
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2482-91.
2000: Xiang Fang; D Gaudette; Tatsuro Furui; Muling Mao; Veronica C Estrella; Astrid Eder; Terri B Pustilnik; T Sasagawa; Ruth Lapushin; Shiangxing Yu; R B Jaffe; Jon R Wiener; James R Erickson; Gordon B Mills
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Annals of the New York Academy of Sciences 2000;905():188-208.
2000: Lois M Ramondetta; Gordon B Mills; Thomas W Burke; Judith K Wolf
Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):278-84.
2000: Xiao-Feng Le; Amanda McWatters; Jon R Wiener; J Y Wu; Gordon B Mills; Robert C Bast
Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):260-70.
1999: Tatsuro Furui; Ruth Lapushin; Muling Mao; H Khan; Steven Watt; M A Watt; Ying Lu; Xiang Fang; S Tsutsui; Zahid H Siddik; Robert C Bast; Gordon B Mills
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4308-18.
1999: David M Gershenson; Michael Deavers; S Diaz; Guillermo Tortolero-Luna; B E Miller; Robert C Bast; Gordon B Mills; Elvio G Silva
Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4053-8.
1999: Ying Lu; Y Z Lin; Ruth Lapushin; Bruce D Cuevas; Xiang Fang; S X Yu; Michael A Davies; H Khan; Tatsuro Furui; Muling Mao; R Zinner; M C Hung; PA Steck; Katherine A Siminovitch; Gordon B Mills
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
1999: Xiang Fang; Shiangxing Yu; Astrid Eder; Muling Mao; Robert C Bast; D Boyd; Gordon B Mills
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway.
Oncogene 1999;18(48):6635-40.
1999: Terri B Pustilnik; Veronica C Estrella; Jon R Wiener; Muling Mao; Astrid Eder; M A Watt; Robert C Bast; Gordon B Mills
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3704-10.
1999: F Xu; Yinhua Yu; Xiao-Feng Le; C Boyer; Gordon B Mills; Robert C Bast
The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3653-60.
1999: Judith K Wolf; Gordon B Mills; L Bazzet; Robert C Bast; Jack A Roth; David M Gershenson
Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
Gynecologic oncology 1999;75(2):261-6.
1999: Bruce D Cuevas; Ying Lu; Steven Watt; Rakesh Kumar; Jinyi Zhang; Katherine A Siminovitch; Gordon B Mills
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
The Journal of biological chemistry 1999;274(39):27583-9.
1999: BK Zebrowski; Wenbiao Liu; Karen M Ramirez; Y Akagi; Gordon B Mills; Lee M Ellis
Markedly elevated levels of vascular endothelial growth factor in malignant ascites.
Annals of surgical oncology 1999;6(4):373-8.
1999: G S Hagopian; Gordon B Mills; Abdul R Khokhar; Robert C Bast; Zahid H Siddik
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):655-63.
1999: Yinhua Yu; F Xu; Hua Peng; Xiang Fang; S Zhao; Y Li; Bruce D Cuevas; Wen-Lin Kuo; Joe Gray; M Siciliano; Gordon B Mills; Robert C Bast
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):214-9.
1998: Michael A Davies; Ying Lu; T Sano; Xiang Fang; P Tang; Ruth Lapushin; Dimpy Koul; Robert Bookstein; David Stokoe; W K Alfred Yung; Gordon B Mills; PA Steck
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.
1998: Ying Lu; Bruce D Cuevas; S Gibson; H Khan; Ruth Lapushin; J Imboden; Gordon B Mills
Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5404-12.
1998: Dimpy Koul; NU Obeyesekere; Jordan U Gutterman; Gordon B Mills; D Choubey
p202 self-associates through a sequence conserved among the members of the 200-family proteins.
FEBS letters 1998;438(1-2):21-4.
1998: Robert C Bast; FJ Xu; YH Yu; SD Barnhill; Zhen Zhang; Gordon B Mills
CA 125: the past and the future.
The International journal of biological markers 1998;13(4):179-87.
1998: Dimpy Koul; Ruth Lapushin; Hong-Ji Xu; Gordon B Mills; Jordan U Gutterman; D Choubey
p202 prevents apoptosis in murine AKR-2B fibroblasts.
Biochemical and biophysical research communications 1998;247(2):379-82.
1998: S Gibson; KE Truitt; Ying Lu; Ruth Lapushin; H Khan; J B Imboden; Gordon B Mills
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
The Biochemical journal 1998;330 ( Pt 3)():1123-8.
1998: Xiang Fang; X Jin; Hong-Ji Xu; Lieqi Liu; HQ Peng; David Hogg; Jack A Roth; Yinhua Yu; F Xu; Robert C Bast; Gordon B Mills
Expression of p16 induces transcriptional downregulation of the RB gene.
Oncogene 1998;16(1):1-8.
1997: David Teng; R Hu; Hui Lin; T Davis; D Iliev; Cynthia Frye; B Swedlund; K L Hansen; V L Vinson; Kathi L Gumpper; L Ellis; Adel El-Naggar; M Frazier; Samar A Jasser; Lauren Langford; J Lee; Gordon B Mills; MA Pershouse; R E Pollack; Carmen Tornos; P Troncoso; W K Alfred Yung; GH Fujii; AE Berson; PA Steck
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Cancer research 1997;57(23):5221-5.
1997: Hong-Ji Xu; Y Zhou; W Ji; G S Perng; R Kruzelock; C T Kong; Robert C Bast; Gordon B Mills; J Li; Shi-Xue Hu
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition.
Oncogene 1997;15(21):2589-96.
1997: FJ Xu; S Stack; C Boyer; KC O'Briant; Regina Whitaker; Gordon B Mills; YH Yu; Robert C Bast
Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1629-34.
1997: Xiang Fang; S Gibson; M Flowers; Tatsuro Furui; Robert C Bast; Gordon B Mills
Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
The Journal of biological chemistry 1997;272(21):13683-9.
1996: S Gibson; A August; Y Kawakami; T Kawakami; Bo Dupont; Gordon B Mills
The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2716-22.
1995: KE Truitt; J Shi; S Gibson; L G Segal; Gordon B Mills; John B Imboden
CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4702-10.
1995: Mark A Goldsmith; SY Lai; W Xu; M C Amaral; E S Kuczek; L J Parent; Gordon B Mills; K L Tarr; Gregory D Longmore; Warner Greene
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
The Journal of biological chemistry 1995;270(37):21729-37.
1994: KE Truitt; Gordon B Mills; Christoph W Turck; John B Imboden
SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
The Journal of biological chemistry 1994;269(8):5937-43.