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Gordon Mills

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Byers Lauren Averett; Sen Banibrata; Saigal Babita; Diao Lixia; Wang Jing; Nanjundan Meera; Cascone Tina; Mills Gordon B; Heymach John V; Johnson Faye M
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Liu Shuying; Murph Mandi; Panupinthu Nattapon; Mills Gordon B
ATX-LPA receptor axis in inflammation and cancer.
Agarwal Roshan; Jurisica Igor; Mills Gordon B; Cheng Kwai Wa
The emerging role of the RAB25 small GTPase in cancer.

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All Publications

2009: Byers Lauren Averett; Sen Banibrata; Saigal Babita; Diao Lixia; Wang Jing; Nanjundan Meera; Cascone Tina; Mills Gordon B; Heymach John V; Johnson Faye M
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6852-61.
2009: Liu Shuying; Murph Mandi; Panupinthu Nattapon; Mills Gordon B
ATX-LPA receptor axis in inflammation and cancer.
Cell cycle (Georgetown, Tex.) 2009;8(22):3695-701.
2009: Agarwal Roshan; Jurisica Igor; Mills Gordon B; Cheng Kwai Wa
The emerging role of the RAB25 small GTPase in cancer.
Traffic (Copenhagen, Denmark) 2009;10(11):1561-8.
2009: Woodman Scott E; Trent Jonathan C; Stemke-Hale Katherine; Lazar Alexander J; Pricl Sabrina; Pavan Giovanni M; Fermeglia Maurizio; Gopal Y N Vashisht; Yang Dan; Podoloff Donald A; Ivan Doina; Kim Kevin B; Papadopoulos Nicholas; Hwu Patrick; Mills Gordon B; Davies Michael A
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Molecular cancer therapeutics 2009;8(8):2079-85.
2009: Mills Gordon B; Jurisica Igor; Yarden Yosef; Norman Jim C
Genomic amplicons target vesicle recycling in breast cancer.
The Journal of clinical investigation 2009;119(8):2123-7.
2009: Liu Shuying; Umezu-Goto Makiko; Murph Mandi; Lu Yiling; Liu Wenbin; Zhang Fan; Yu Shuangxing; Stephens L Clifton; Cui Xiaojiang; Murrow George; Coombes Kevin; Muller William; Hung Mien-Chie; Perou Charles M; Lee Adrian V; Fang Xianjun; Mills Gordon B
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2009: Agarwal Roshan; Gonzalez-Angulo Ana-Maria; Myhre Simen; Carey Mark; Lee Ju-Seog; Overgaard Jens; Alsner Jan; Stemke-Hale Katherine; Lluch Ana; Neve Richard M; Kuo Wen Lin; Sorlie Therese; Sahin Aysegul; Valero Vicente; Keyomarsi Khandan; Gray Joe W; Borresen-Dale Anne-Lise; Mills Gordon B; Hennessy Bryan T
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3654-62.
2009: Bast Robert C; Hennessy Bryan; Mills Gordon B
The biology of ovarian cancer: new opportunities for translation.
Nature reviews. Cancer 2009;9(6):415-28.
2009: Hennessy Bryan T; Gonzalez-Angulo Ana-Maria; Stemke-Hale Katherine; Gilcrease Michael Z; Krishnamurthy Savitri; Lee Ju-Seog; Fridlyand Jane; Sahin Aysegul; Agarwal Roshan; Joy Corwin; Liu Wenbin; Stivers David; Baggerly Keith; Carey Mark; Lluch Ana; Monteagudo Carlos; He Xiaping; Weigman Victor; Fan Cheng; Palazzo Juan; Hortobagyi Gabriel N; Nolden Laura K; Wang Nicholas J; Valero Vicente; Gray Joe W; Perou Charles M; Mills Gordon B
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Cancer research 2009;69(10):4116-24.
2009: Yim Eun-Kyoung; Peng Guang; Dai Hui; Hu Ruozhen; Li Kaiyi; Lu Yiling; Mills Gordon B; Meric-Bernstam Funda; Hennessy Bryan T; Craven Rolf J; Lin Shiaw-Yih
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Cancer cell 2009;15(4):304-14.
2009: Gonzalez-Angulo Ana M; Stemke-Hale Katherine; Palla Shana L; Carey Mark; Agarwal Roshan; Meric-Berstam Funda; Traina Tiffany A; Hudis Clifford; Hortobagyi Gabriel N; Gerald William L; Mills Gordon B; Hennessy Bryan T
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2472-8.
2009: Nikolova Dessislava A; Asangani Irfan A; Nelson Laura D; Hughes Dennis P M; Siwak Doris R; Mills Gordon B; Harms Andrea; Buchholz Erika; Pilz Lothar R; Manegold Christian; Allgayer Heike
Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
Cancer research 2009;69(6):2461-70.
2009: Zinner Ralph G; Barrett Brittany L; Popova Elmira; Damien Paul; Volgin Andrei Y; Gelovani Juri G; Lotan Reuben; Tran Hai T; Pisano Claudio; Mills Gordon B; Mao Li; Hong Waun K; Lippman Scott M; Miller John H
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
Molecular cancer therapeutics 2009;8(3):521-32.
2009: Tuna Musaffe; Knuutila Sakari; Mills Gordon B
Uniparental disomy in cancer.
Trends in molecular medicine 2009;15(3):120-8.
2009: Zhang Li; Wei Qingyi; Mao Li; Liu Wenbin; Mills Gordon B; Coombes Kevin
Serial dilution curve: a new method for analysis of reverse phase protein array data.
Bioinformatics (Oxford, England) 2009;25(5):650-4.
2009: Pamuklar Zehra; Federico Lorenzo; Liu Shuying; Umezu-Goto Makiko; Dong Anping; Panchatcharam Manikandan; Fulerson Zachary; Berdyshev Evgeny; Natarajan Viswanathan; Fang Xianjun; van Meeteren Laurens A; Moolenaar Wouter H; Mills Gordon B; Morris Andrew J; Smyth Susan S
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
The Journal of biological chemistry 2009;284(11):7385-94.
2009: Hennessy Bryan T; Gonzalez-Angulo Ana Maria; Carey Mark S; Mills Gordon B
A systems approach to analysis of molecular complexity in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):417-9.
2009: Mirzoeva Olga K; Das Debopriya; Heiser Laura M; Bhattacharya Sanchita; Siwak Doris; Gendelman Rina; Bayani Nora; Wang Nicholas J; Neve Richard M; Guan Yinghui; Hu Zhi; Knight Zachary; Feiler Heidi S; Gascard Philippe; Parvin Bahram; Spellman Paul T; Shokat Kevan M; Wyrobek Andrew J; Bissell Mina J; McCormick Frank; Kuo Wen-Lin; Mills Gordon B; Gray Joe W; Korn W Michael
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Cancer research 2009;69(2):565-72.
2009: Ihle Nathan T; Lemos Robert; Wipf Peter; Yacoub Adly; Mitchell Clint; Siwak Doris; Mills Gordon B; Dent Paul; Kirkpatrick D Lynn; Powis Garth
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Cancer research 2009;69(1):143-50.
2009: Kornblau Steven M; Tibes Raoul; Qiu Yi Hua; Chen Wenjing; Kantarjian Hagop M; Andreeff Michael; Coombes Kevin R; Mills Gordon B
Functional proteomic profiling of AML predicts response and survival.
Blood 2009;113(1):154-64.
2009: Murph Mandi M; Liu Wenbin; Yu Shuangxing; Lu Yiling; Hall Hassan; Hennessy Bryan T; Lahad John; Schaner Marci; Helland Aslaug; Kristensen Gunnar; Børresen-Dale Anne-Lise; Mills Gordon B
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
PloS one 2009;4(5):e5583.
2008: Yu Shuangxing; Murph Mandi M; Lu Yiling; Liu Shuying; Hall Hassan S; Liu Jinsong; Stephens Clifton; Fang Xianjun; Mills Gordon B
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Journal of the National Cancer Institute 2008;100(22):1630-42.
2008: Lambert Laura A; Qiao Na; Hunt Kelly K; Lambert Donald H; Mills Gordon B; Meijer Laurent; Keyomarsi Khandan
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
Cancer research 2008;68(19):7966-74.
2008: Davies M A; Stemke-Hale K; Tellez C; Calderone T L; Deng W; Prieto V G; Lazar A J F; Gershenwald J E; Mills G B
A novel AKT3 mutation in melanoma tumours and cell lines.
British journal of cancer 2008;99(8):1265-8.
2008: Yokoyama T; Iwado E; Kondo Y; Aoki H; Hayashi Y; Georgescu M M; Sawaya R; Hess K R; Mills G B; Kawamura H; Hashimoto Y; Urata Y; Fujiwara T; Kondo S
Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Gene therapy 2008;15(17):1233-9.
2008: Murph Mandi M; Nguyen Giang H; Radhakrishna Harish; Mills Gordon B
Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.
Biochimica et biophysica acta 2008;1781(9):547-57.
2008: Wei Yongkun; Xia Weiya; Zhang Zhihong; Liu Jinsong; Wang Huamin; Adsay Nazmi V; Albarracin Constance; Yu Dihua; Abbruzzese James L; Mills Gordon B; Bast Robert C; Hortobagyi Gabriel N; Hung Mien-Chie
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Nanjundan Meera; Cheng Kwai Wa; Zhang Fan; Lahad John; Kuo Wen-Lin; Schmandt Rosemarie; Smith-McCune Karen; Fishman David; Gray Joe W; Mills Gordon B
Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
Molecular oncology 2008;2(2):164-81.
2008: Stemke-Hale Katherine; Gonzalez-Angulo Ana Maria; Lluch Ana; Neve Richard M; Kuo Wen-Lin; Davies Michael; Carey Mark; Hu Zhi; Guan Yinghui; Sahin Aysegul; Symmans W Fraser; Pusztai Lajos; Nolden Laura K; Horlings Hugo; Berns Katrien; Hung Mien-Chie; van de Vijver Marc J; Valero Vicente; Gray Joe W; Bernards René; Mills Gordon B; Hennessy Bryan T
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2008: Grote Tobias; Siwak Doris R; Fritsche Herbert A; Joy Corwin; Mills Gordon B; Simeone Diane; Whitcomb David C; Logsdon Craig D
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer.
Proteomics 2008;8(15):3051-60.
2008: Hasegawa Yutaka; Murph Mandi; Yu Shuangxing; Tigyi Gabor; Mills Gordon B
Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Molecular oncology 2008;2(1):54-69.
2008: Muller Melissa; Obeyesekere Mandri; Mills Gordon B; Ram Prahlad T
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1393-403.
2008: Liu Shuying; Fang Xianjun; Hall Hassan; Yu Shuangxing; Smith Debra; Lu Zhimin; Fang Dexing; Liu Jinsong; Stephens L Clifton; Woodgett James R; Mills Gordon B
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
2008: Ji Yuan; Lu Yiling; Mills Gordon B
Bayesian models based on test statistics for multiple hypothesis testing problems.
Bioinformatics (Oxford, England) 2008;24(7):943-9.
2008: Yang Jer-Yen; Zong Cong S; Xia Weiya; Yamaguchi Hirohito; Ding Qingqing; Xie Xiaoming; Lang Jing-Yu; Lai Chien-Chen; Chang Chun-Ju; Huang Wei-Chien; Huang Hsin; Kuo Hsu-Ping; Lee Dung-Fang; Li Long-Yuan; Lien Huang-Chun; Cheng Xiaoyun; Chang King-Jen; Hsiao Chwan-Deng; Tsai Fuu-Jen; Tsai Chang-Hai; Sahin Aysegul A; Muller William J; Mills Gordon B; Yu Dihua; Hortobagyi Gabriel N; Hung Mien-Chie
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Nature cell biology 2008;10(2):138-48.
2008: Freire Pablo; Vilela Marco; Deus Helena; Kim Yong-Wan; Koul Dimpy; Colman Howard; Aldape Kenneth D; Bogler Oliver; Yung W K Alfred; Coombes Kevin; Mills Gordon B; Vasconcelos Ana T; Almeida Jonas S
Exploratory analysis of the copy number alterations in glioblastoma multiforme.
PloS one 2008;3(12):e4076.
2008: Stanislaus Romesh; Carey Mark; Deus Helena F; Coombes Kevin; Hennessy Bryan T; Mills Gordon B; Almeida Jonas S
RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays.
BMC bioinformatics 2008;9():555.
2008: Hennessy Bryan T; Murph Mandi; Nanjundan Meera; Carey Mark; Auersperg Nelly; Almeida Jonas; Coombes Kevin R; Liu Jinsong; Lu Yiling; Gray Joe W; Mills Gordon B
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Advances in experimental medicine and biology 2008;617():23-40.
2007: Gajewiak Joanna; Tsukahara Ryoko; Tsukahara Tamotsu; Fujiwara Yuko; Yu Shuanxing; Lu Yiling; Murph Mandi; Mills Gordon B; Tigyi Gabor; Prestwich Glenn D
Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
ChemMedChem 2007;2(12):1789-98.
2007: Xu Z-X; Liang J; Haridas V; Gaikwad A; Connolly F P; Mills G B; Gutterman J U
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Cell death and differentiation 2007;14(11):1948-57.
2007: Berns Katrien; Horlings Hugo M; Hennessy Bryan T; Madiredjo Mandy; Hijmans E Marielle; Beelen Karin; Linn Sabine C; Gonzalez-Angulo Ana Maria; Stemke-Hale Katherine; Hauptmann Michael; Beijersbergen Roderick L; Mills Gordon B; van de Vijver Marc J; Bernards René
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Cancer cell 2007;12(4):395-402.
2007: Lu Chien-Hsing; Wyszomierski Shannon L; Tseng Ling-Ming; Sun Meng-Hong; Lan Keng-Hsueh; Neal Christopher L; Mills Gordon B; Hortobagyi Gabriel N; Esteva Francisco J; Yu Dihua
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5883-8.
2007: Guan Yinghui; Kuo Wen-Lin; Stilwell Jackie L; Takano Hirokuni; Lapuk Anna V; Fridlyand Jane; Mao Jian-Hua; Yu Mamie; Miller Melinda A; Santos Jennifer L; Kalloger Steve E; Carlson Joseph W; Ginzinger David G; Celniker Susan E; Mills Gordon B; Huntsman David G; Gray Joe W
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5745-55.
2007: Fujiwara Keishi; Iwado Eiji; Mills Gordon B; Sawaya Raymond; Kondo Seiji; Kondo Yasuko
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
International journal of oncology 2007;31(4):753-60.
2007: Lu Yang; Li Xinqun; Liang Ke; Luwor Rodney; Siddik Zahid H; Mills Gordon B; Mendelsohn John; Fan Zhen
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
Cancer research 2007;67(17):8240-7.
2007: Aoki Hiroshi; Iwado Eiji; Eller Mark S; Kondo Yasuko; Fujiwara Keishi; Li Guang-Zhi; Hess Kenneth R; Siwak Doris R; Sawaya Raymond; Mills Gordon B; Gilchrest Barbara A; Kondo Seiji
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2918-30.
2007: Estrella Veronica C; Eder Astrid M; Liu Shuying; Pustilnik Terri B; Tabassam Fazal H; Claret Francois X; Gallick Gary E; Mills Gordon B; Wiener Jon R
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
International journal of oncology 2007;31(2):441-9.
2007: Yamasaki Fumiyuki; Johansen Mary J; Zhang Dongwei; Krishnamurthy Savitri; Felix Edward; Bartholomeusz Chandra; Aguilar Richard J; Kurisu Kaoru; Mills Gordon B; Hortobagyi Gabriel N; Ueno Naoto T
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Cancer research 2007;67(12):5779-88.
2007: Zhang Qing; Bhola Neil E; Lui Vivian Wai Yan; Siwak Doris R; Thomas Sufi M; Gubish Christopher T; Siegfried Jill M; Mills Gordon B; Shin Dong; Grandis Jennifer Rubin
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Molecular cancer therapeutics 2007;6(4):1414-24.
2007: Nanjundan Meera; Nakayama Yasuhisa; Cheng Kwai Wa; Lahad John; Liu Jinsong; Lu Karen; Kuo Wen-Lin; Smith-McCune Karen; Fishman David; Gray Joe W; Mills Gordon B
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Cancer research 2007;67(7):3074-84.
2007: Fang Dexing; Hawke David; Zheng Yanhua; Xia Yan; Meisenhelder Jill; Nika Heinz; Mills Gordon B; Kobayashi Ryuji; Hunter Tony; Lu Zhimin
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
The Journal of biological chemistry 2007;282(15):11221-9.
2007: Nanjundan M; Zhang F; Schmandt R; Smith-McCune K; Mills G B
Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
Oncogene 2007;26(18):2574-84.
2007: Iwamaru A; Kondo Y; Iwado E; Aoki H; Fujiwara K; Yokoyama T; Mills G B; Kondo S
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Oncogene 2007;26(13):1840-51.
2007: Liang Jiyong; Shao Shan H; Xu Zhi-Xiang; Hennessy Bryan; Ding Zhiyong; Larrea Michelle; Kondo Seiji; Dumont Dan J; Gutterman Jordan U; Walker Cheryl L; Slingerland Joyce M; Mills Gordon B
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Nature cell biology 2007;9(2):218-24.
2007: Tabe Yoko; Jin Linhua; Tsutsumi-Ishii Yuko; Xu Yuanyuan; McQueen Teresa; Priebe Waldemar; Mills Gordon B; Ohsaka Akimichi; Nagaoka Isao; Andreeff Michael; Konopleva Marina
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Cancer research 2007;67(2):684-94.
2007: Younes Maher N; Yigitbasi Orhan G; Yazici Yasemin D; Jasser Samar A; Bucana Cora D; El-Naggar Adel K; Mills Gordon B; Myers Jeffrey N
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Archives of otolaryngology--head & neck surgery 2007;133(1):15-23.
2007: Yang Gong; Rosen Daniel G; Mercado-Uribe Imelda; Colacino Justin A; Mills Gordon B; Bast Robert C; Zhou Chenyi; Liu Jinsong
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Carcinogenesis 2007;28(1):174-82.
2007: Murph Mandi; Mills Gordon B
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Expert reviews in molecular medicine 2007;9(28):1-18.
2007: Bast Robert C; Brewer Molly; Zou Changping; Hernandez Mary A; Daley Mary; Ozols Robert; Lu Karen; Lu Zhen; Badgwell Donna; Mills Gordon B; Skates Steven; Zhang Zhen; Chan Dan; Lokshin Anna; Yu Yinhua
Prevention and early detection of ovarian cancer: mission impossible?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():91-100.
2006: Murph Mandi; Tanaka Tamotsu; Liu Shuying; Mills Gordon B
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6598-602.
2006: Stemke-Hale Katherine; Hennessy Bryan; Mills Gordon B; Mitra Rahul
Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein.
Current oncology reports 2006;8(6):484-91.
2006: Yang Gong; Rosen Daniel G; Zhang Zhihong; Bast Robert C; Mills Gordon B; Colacino Justin A; Mercado-Uribe Imelda; Liu Jinsong
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16472-7.
2006: Tibes Raoul; Qiu Yihua; Lu Yiling; Hennessy Bryan; Andreeff Michael; Mills Gordon B; Kornblau Steven M
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Molecular cancer therapeutics 2006;5(10):2512-21.
2006: Ding Zhiyong; Liang Jiyong; Lu Yiling; Yu Qinghua; Songyang Zhou; Lin Shiaw-Yih; Mills Gordon B
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15014-9.
2006: Rai Rekha; Dai Hui; Multani Asha S; Li Kaiyi; Chin Koei; Gray Joe; Lahad John P; Liang Jiyong; Mills Gordon B; Meric-Bernstam Funda; Lin Shiaw-Yih
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Cancer cell 2006;10(2):145-57.
2006: Baker Daniel L; Fujiwara Yuko; Pigg Kathryn R; Tsukahara Ryoko; Kobayashi Susumu; Murofushi Hiromu; Uchiyama Ayako; Murakami-Murofushi Kimiko; Koh Eunjin; Bandle Russell W; Byun Hoe-Sup; Bittman Robert; Fan Dominic; Murph Mandi; Mills Gordon B; Tigyi Gabor
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
The Journal of biological chemistry 2006;281(32):22786-93.
2006: Zhang Qing; Thomas Sufi M; Lui Vivian Wai Yan; Xi Sichuan; Siegfried Jill M; Fan Huizhou; Smithgall Thomas E; Mills Gordon B; Grandis Jennifer Rubin
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6901-6.
2006: Rosen Daniel G; Yang Gong; Deavers Michael T; Malpica Anais; Kavanagh John J; Mills Gordon B; Liu Jinsong
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.
Cancer 2006;106(9):1925-32.
2006: Li Xinqun; Lu Yang; Jin Weidong; Liang Ke; Mills Gordon B; Fan Zhen
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
The Journal of biological chemistry 2006;281(19):13837-43.
2006: Zeng Zhihong; Samudio Ismael J; Zhang Weiguo; Estrov Zeev; Pelicano Hélène; Harris David; Frolova Olga; Hail Numsen; Chen Wenjing; Kornblau Steven M; Huang Peng; Lu Yiling; Mills Gordon B; Andreeff Michael; Konopleva Marina
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Cancer research 2006;66(7):3737-46.
2006: Mandal Mahitosh; Younes Maher; Swan Eric A; Jasser Samar A; Doan Dao; Yigitbasi Orhan; McMurphey Andrea; Ludwick James; El-Naggar Adel K; Bucana Cora; Mills Gordon B; Myers Jeffrey N
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Oral oncology 2006;42(4):430-9.
2006: Hennessy Bryan T; Nanjundan Meera; Cheng Kwai Wa; Nolden Laura; Mills Gordon B
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
European journal of human genetics : EJHG 2006;14(4):381-3.
2006: Qian Lian; Xu Yong; Simper Ted; Jiang Guowei; Aoki Junken; Umezu-Goto Makiko; Arai Hiroyuki; Yu Shuangxing; Mills Gordon B; Tsukahara Ryoko; Makarova Natalia; Fujiwara Yuko; Tigyi Gabor; Prestwich Glenn D
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
2006: Koul Dimpy; Shen Ruijun; Bergh Sherry; Sheng Xiaoyang; Shishodia Shishir; Lafortune Tiffany A; Lu Yiling; de Groot John F; Mills Gordon B; Yung W K Alfred
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Molecular cancer therapeutics 2006;5(3):637-44.
2006: Zhu Quan-Sheng; Xia Ling; Mills Gordon B; Lowell Clifford A; Touw Ivo P; Corey Seth J
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
Blood 2006;107(5):1847-56.
2006: Georgakis Georgios V; Li Yang; Rassidakis Georgios Z; Medeiros L Jeffrey; Mills Gordon B; Younes Anas
Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
British journal of haematology 2006;132(4):503-11.
2006: Barcenas Carlos H; Hosain G M Monawar; Arun Banu; Zong Jihong; Zhou Xiaojun; Chen Jianfang; Cortada Jill M; Mills Gordon B; Tomlinson Gail E; Miller Alexander R; Strong Louise C; Amos Christopher I
Assessing BRCA carrier probabilities in extended families.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(3):354-60.
2006: Hennessy B T; Mills G B
Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling.
The international journal of biochemistry & cell biology 2006;38(9):1450-6.
2005: Hennessy Bryan T; Smith Debra L; Ram Prahlad T; Lu Yiling; Mills Gordon B
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Nature reviews. Drug discovery 2005;4(12):988-1004.
2005: Koul Dimpy; Shen Ruijun; Bergh Sherry; Lu Yiling; de Groot John F; Liu Ta Jen; Mills Gordon B; Yung W K Alfred
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Molecular cancer therapeutics 2005;4(11):1681-8.
2005: Marquez Rebecca T; Baggerly Keith A; Patterson Andrea P; Liu Jinsong; Broaddus Russell; Frumovitz Michael; Atkinson Edward N; Smith David I; Hartmann Lynn; Fishman David; Berchuck Andrew; Whitaker Regina; Gershenson David M; Mills Gordon B; Bast Robert C; Lu Karen H
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6116-26.
2005: Eder Astrid M; Sui Xiaomei; Rosen Daniel G; Nolden Laura K; Cheng Kwai Wa; Lahad John P; Kango-Singh Madhuri; Lu Karen H; Warneke Carla L; Atkinson Edward N; Bedrosian Isabelle; Keyomarsi Khandan; Kuo Wen-lin; Gray Joe W; Yin Jerry C P; Liu Jinsong; Halder Georg; Mills Gordon B
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12519-24.
2005: Younes Maher N; Kim Seungwon; Yigitbasi Orhan G; Mandal Mahitosh; Jasser Samar A; Dakak Yazici Yasemin; Schiff Bradley A; El-Naggar Adel; Bekele Benjamin N; Mills Gordon B; Myers Jeffrey N
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Molecular cancer therapeutics 2005;4(8):1146-56.
2005: Nishimoto Arata; Yu Yinhua; Lu Zhen; Mao Xiang; Ren Zhiyong; Watowich Stephanie S; Mills Gordon B; Liao Warren S-L; Chen Xiaomin; Bast Robert C; Luo Robert Z
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Cancer research 2005;65(15):6701-10.
2005: Liu Zhensheng; Wang Li-E; Wang Luo; Lu Karen H; Mills Gordon B; Bondy Melissa L; Wei Qingyi
Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4968-76.
2005: Lahad John P; Mills Gordon B; Coombes Kevin R
Stem cell-ness: a "magic marker" for cancer.
The Journal of clinical investigation 2005;115(6):1463-7.
2005: Mandal M; Kim S; Younes M N; Jasser S A; El-Naggar A K; Mills G B; Myers J N
The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
British journal of cancer 2005;92(10):1899-905.
2005: Xu Yong; Aoki Junken; Shimizu Kumiko; Umezu-Goto Makiko; Hama Kotaro; Takanezawa Yasukazu; Yu Shuangxing; Mills Gordon B; Arai Hiroyuki; Qian Lian; Prestwich Glenn D
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
2005: Takeuchi Hayato; Kondo Yasuko; Fujiwara Keishi; Kanzawa Takao; Aoki Hiroshi; Mills Gordon B; Kondo Seiji
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Cancer research 2005;65(8):3336-46.
2005: Cheng Kwai W; Lahad John P; Gray Joseph W; Mills Gordon B
Emerging role of RAB GTPases in cancer and human disease.
Cancer research 2005;65(7):2516-9.
2005: Sheehan Katherine M; Calvert Valerie S; Kay Elaine W; Lu Yiling; Fishman David; Espina Virginia; Aquino Joy; Speer Runa; Araujo Robyn; Mills Gordon B; Liotta Lance A; Petricoin Emanuel F; Wulfkuhle Julia D
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
Molecular & cellular proteomics : MCP 2005;4(4):346-55.
2005: Dong Jinjiang; Peng Junying; Zhang Haixia; Mondesire Wallace H; Jian Weiguo; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 2005;65(5):1961-72.
2005: Le Xiao-Feng; Lammayot Amy; Gold David; Lu Yiling; Mao Weiqun; Chang Teresa; Patel Adarsh; Mills Gordon B; Bast Robert C
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
The Journal of biological chemistry 2005;280(3):2092-104.
2004: Meric-Bernstam Funda; Mills Gordon B
Mammalian target of rapamycin.
Seminars in oncology 2004;31(6 Suppl 16):10-7; discussion 33.
2004: Liu Shuying; Yu Shuangxing; Hasegawa Yutaka; Lapushin Ruth; Xu Hong-Ji; Woodgett James R; Mills Gordon B; Fang Xianjun
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
2004: Cheng Kwai Wa; Lahad John P; Kuo Wen-Lin; Lapuk Anna; Yamada Kyosuke; Auersperg Nelly; Liu Jinsong; Smith-McCune Karen; Lu Karen H; Fishman David; Gray Joe W; Mills Gordon B
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Nature medicine 2004;10(11):1251-6.
2004: Mondesire Wallace H; Jian Weiguo; Zhang Haixia; Ensor Joe; Hung Mien-Chie; Mills Gordon B; Meric-Bernstam Funda
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7031-42.
2004: Umezu-Goto Makiko; Tanyi Janos; Lahad John; Liu Shuying; Yu Shuangxing; Lapushin Ruth; Hasegawa Yutaka; Lu Yiling; Trost Rosanne; Bevers Therese; Jonasch Eric; Aldape Ken; Liu Jinsong; James Robyn D; Ferguson Colin G; Xu Yong; Prestwich Glenn D; Mills Gordon B
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
2004: Lu Karen H; Patterson Andrea P; Wang Lin; Marquez Rebecca T; Atkinson Edward N; Baggerly Keith A; Ramoth Lance R; Rosen Daniel G; Liu Jinsong; Hellstrom Ingegerd; Smith David; Hartmann Lynn; Fishman David; Berchuck Andrew; Schmandt Rosemarie; Whitaker Regina; Gershenson David M; Mills Gordon B; Bast Robert C
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3291-300.
2004: Cheng Kwai Wa; Lahad John P; Mills Gordon B
Analysis of molecular aberrations in ovarian cancer allows novel target identification.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC 2004;26(5):461-74.
2004: Sellappan Shankar; Grijalva Rebecca; Zhou Xiaoyan; Yang Wentao; Eli Menashe Bar; Mills Gordon B; Yu Dihua
Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line.
Cancer research 2004;64(10):3479-85.
2004: Liu Jinsong; Yang Gong; Thompson-Lanza Jennifer A; Glassman Armand; Hayes Kimberly; Patterson Andrea; Marquez Rebecca T; Auersperg Nelly; Yu Yinhua; Hahn William C; Mills Gordon B; Bast Robert C
A genetically defined model for human ovarian cancer.
Cancer research 2004;64(5):1655-63.
2004: Fang Xianjun; Yu Shuangxing; Bast Robert C; Liu Shuying; Xu Hong-Ji; Hu Shi-Xue; LaPushin Ruth; Claret Francois X; Aggarwal Bharat B; Lu Yiling; Mills Gordon B
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2004: Kohn Elise C; Lu Yiling; Wang Hongwei; Yu Qinghua; Yu Shuangxing; Hall Hassan; Smith Debra L; Meric-Bernstam Funda; Hortobagyi Gabriel N; Mills Gordon B
Molecular therapeutics: promise and challenges.
Seminars in oncology 2004;31(1 Suppl 3):39-53.
2004: Noh Woo-Chul; Mondesire Wallace H; Peng Junying; Jian Weiguo; Zhang Haixia; Dong JinJiang; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Determinants of rapamycin sensitivity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1013-23.
2004: Zhao S; Konopleva M; Cabreira-Hansen M; Xie Z; Hu W; Milella M; Estrov Z; Mills G B; Andreeff M
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(2):267-75.
2004: Andreeff M; Milella M; Carter B Z; Tabe Y; Ricciardi M R; Sneed T; Ruvolo P; Contractor R; Tsao T; Schober W; Evans R; McQueen T; Zeng Z; Kornblau S M; McCubrey J; Estey E; Mills G B; Reed J C; Konopleva M
Targeted therapy of AML new concepts.
Annals of hematology 2004;83 Suppl 1():S51-3.
2003: Qian Lian; Xu Yong; Hasegawa Yutaka; Aoki Junken; Mills Gordon B; Prestwich Glenn D
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Journal of medicinal chemistry 2003;46(26):5575-8.
2003: Mills Gordon B; Kohn Elise; Lu Yiling; Eder Astrid; Fang Xianjun; Wang Hongwei; Bast Robert C; Gray Joe; Jaffe Robert; Hortobagyi Gabriel
Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):93-104.
2003: Lu Yiling; Yu Qinghua; Liu Jue Hui; Zhang Jinyi; Wang Hongwei; Koul Dimpy; McMurray John S; Fang Xianjun; Yung W K Alfred; Siminovitch Kathy A; Mills Gordon B
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
The Journal of biological chemistry 2003;278(41):40057-66.
2003: Tanyi Janos L; Hasegawa Yutaka; Lapushin Ruth; Morris Andrew J; Wolf Judith K; Berchuck Andrew; Lu Karen; Smith David I; Kalli Kimberly; Hartmann Lynn C; McCune Karen; Fishman David; Broaddus Russell; Cheng Kwai W; Atkinson Edward N; Yamal Jose M; Bast Robert C; Felix Edward A; Newman Robert A; Mills Gordon B
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3534-45.
2003: Clair Timothy; Aoki Junken; Koh Eunjin; Bandle Russell W; Nam Suk Woo; Ptaszynska Malgorzata M; Mills Gordon B; Schiffmann Elliott; Liotta Lance A; Stracke Mary L
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer research 2003;63(17):5446-53.
2003: Hu S X; Wang S; Wang J P; Mills G B; Zhou Y; Xu H-J
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
British journal of cancer 2003;89(1):135-9.
2003: Shvartsman Hyun S; Lu Karen H; Lee John; Lillie Jim; Deavers Michael T; Clifford Stephanie; Wolf Judith K; Mills Gordon B; Bast Robert C; Gershenson David M; Schmandt Rosemarie
Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
Gynecologic oncology 2003;90(1):44-50.
2003: Lu Yiling; Wang Hongwei; Mills Gordon B
Targeting PI3K-AKT pathway for cancer therapy.
Reviews in clinical and experimental hematology 2003;7(2):205-28.
2003: Lee Ho-Young; Srinivas Harish; Xia Dianren; Lu Yiling; Superty Robert; LaPushin Ruth; Gomez-Manzano Candelaria; Gal Anna Maria; Walsh Garrett L; Force Thomas; Ueki Kohjiro; Mills Gordon B; Kurie Jonathan M
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
The Journal of biological chemistry 2003;278(26):23630-8.
2003: Luo Robert Z; Fang Xianjun; Marquez Rebecca; Liu Shu-Ying; Mills Gordon B; Liao Warren S-L; Yu Yinhua; Bast Robert C
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Oncogene 2003;22(19):2897-909.
2003: Knuefermann Christiane; Lu Yang; Liu Bolin; Jin Weidong; Liang Ke; Wu Ling; Schmidt Mathias; Mills Gordon B; Mendelsohn John; Fan Zhen
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Oncogene 2003;22(21):3205-12.
2003: Mansouri Abdellah; Ridgway Lon D; Korapati Anita L; Zhang Qingxiu; Tian Ling; Wang Yibin; Siddik Zahid H; Mills Gordon B; Claret François X
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
The Journal of biological chemistry 2003;278(21):19245-56.
2003: Liang Ke; Jin Weidong; Knuefermann Christiane; Schmidt Mathias; Mills Gordon B; Ang K Kian; Milas Luka; Fan Zhen
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Molecular cancer therapeutics 2003;2(4):353-60.
2003: Cui Xiaojiang; Zhang Ping; Deng Wanleng; Oesterreich Steffi; Lu Yiling; Mills Gordon B; Lee Adrian V
Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):575-88.
2003: Hasegawa Yutaka; Erickson James R; Goddard Graham J; Yu Shuangxing; Liu Shuying; Cheng Kwai Wa; Eder Astrid; Bandoh Koji; Aoki Junken; Jarosz Renata; Schrier Andrew D; Lynch Kevin R; Mills Gordon B; Fang Xianjun
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
2003: Tanyi Janos L; Morris Andrew J; Wolf Judith K; Fang Xianjun; Hasegawa Yutaka; Lapushin Ruth; Auersperg Nelly; Sigal Yury J; Newman Robert A; Felix Edward A; Atkinson Edward N; Mills Gordon B
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
2003: Aytac U; Sato K; Yamochi T; Yamochi T; Ohnuma K; Mills G B; Morimoto C; Dang N H
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
British journal of cancer 2003;88(3):455-62.
2003: Mills Gordon B; Fang Xianjun; Lu Yiling; Hasegawa Yutaka; Eder Astrid; Tanyi Janos; Tabassam Fazad Haq; Mao Muling; Wang Hongwei; Cheng Kwai Wa; Nakayama Yasuhisa; Kuo Wenlin; Erickson Jim; Gershenson David; Kohn Elise C; Jaffe Robert; Bast Robert C; Gray Joe
Specific keynote: molecular therapeutics in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S88-92; discussion S93-6.
2003: Bast Robert C; Mills Gordon B
General keynote: molecular therapeutics and pharmocogenomics.
Gynecologic oncology 2003;88(1 Pt 2):S84-7; discussion S93-6.
2003: Liotta Lance A; Petricoin Emanuel F; Ardekani Ali M; Hitt Ben A; Levine Peter J; Fusaro Vincent A; Steinberg Seth M; Mills Gordon B; Simone Charles; Fishman David A; Kohn Elise C
General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S25-8; discussion S37-42.
2003: Gray Joe W; Suzuki Seiji; Kuo Wen-Lin; Polikoff Daniel; Deavers Michael; Smith-McCune Karen; Berchuck Andrew; Pinkel Dan; Albertson Donna; Mills Gordon B
Specific keynote: genome copy number abnormalities in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S16-21; discussion S22-4.
2003: Le Xiao-Feng; Hittelman Walter N; Liu Jiaxin; McWatters Amanda; Li Chun; Mills Gordon B; Bast Robert C
Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.
Oncogene 2003;22(4):484-97.
2003: Wiener Jon R; Windham T Christopher; Estrella Veronica C; Parikh Nila U; Thall Peter F; Deavers Michael T; Bast Robert C; Mills Gordon B; Gallick Gary E
Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.
Gynecologic oncology 2003;88(1):73-9.
2002: Bondar Victor M; Sweeney-Gotsch Bridget; Andreeff Michael; Mills Gordon B; McConkey David J
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Molecular cancer therapeutics 2002;1(12):989-97.
2002: Umezu-Goto Makiko; Kishi Yasuhiro; Taira Akitsu; Hama Kotaro; Dohmae Naoshi; Takio Koji; Yamori Takao; Mills Gordon B; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
2002: Tanyi Janos L; Lapushin Ruth; Eder Astrid; Auersperg Nelly; Tabassam Fazal H; Roth Jack A; Gu Jian; Fang Binglian; Mills Gordon B; Wolf Judith
Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Gynecologic oncology 2002;85(3):451-8.
2002: Fang Xianjun; Schummer Michel; Mao Muling; Yu Shuangxing; Tabassam Fazal Haq; Swaby Ramona; Hasegawa Yutaka; Tanyi Janos L; LaPushin Ruthie; Eder Astrid; Jaffe Robert; Erickson Jim; Mills Gordon B
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
2002: Koul Dimpy; Jasser Samar A; Lu Yiling; Davies Michael A; Shen Ruijun; Shi Yuexi; Mills Gordon B; Yung W K Alfred
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Oncogene 2002;21(15):2357-64.
2002: Fang Xianjun; Yu Shuangxing; Tanyi Janos L; Lu Yiling; Woodgett James R; Mills Gordon B
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology 2002;22(7):2099-110.
2002: Kuo Macus Tien; Liu Zesheng; Wei Yingjie; Lin-Lee Yen-chiu; Tatebe Shigeru; Mills Gordon B; Unate Hitoshi
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.
Oncogene 2002;21(13):1945-54.
2002: Petricoin Emanuel F; Ardekani Ali M; Hitt Ben A; Levine Peter J; Fusaro Vincent A; Steinberg Seth M; Mills Gordon B; Simone Charles; Fishman David A; Kohn Elise C; Liotta Lance A
Use of proteomic patterns in serum to identify ovarian cancer.
Lancet 2002;359(9306):572-7.
2002: Buchholz Thomas A; Wu Xifeng; Hussain Abu; Tucker Susan L; Mills Gordon B; Haffty Bruce; Bergh Sherry; Story Michael; Geara Fady B; Brock William A
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
International journal of cancer. Journal international du cancer 2002;97(5):557-61.
2002: Mills Gordon B; Eder Astrid; Fang Xianjun; Hasegawa Yutaka; Mao Muling; Lu Yiling; Tanyi Janos; Tabassam Fazal Haq; Wiener Jon; Lapushin Ruth; Yu Shiangxing; Parrott Jeff A; Compton Tim; Tribley Walter; Fishman David; Stack M Sharon; Gaudette Douglas; Jaffe Robert; Furui Tatsuro; Aoki Junken; Erickson James R
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
2001: Le X F; Marcelli M; McWatters A; Nan B; Mills G B; O'Brian C A; Bast R C
Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Oncogene 2001;20(57):8258-69.
2001: Zhu Y; Spitz M R; Lei L; Mills G B; Wu X
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility.
Cancer research 2001;61(21):7825-9.
2001: Mills G B; Lu Y; Fang X; Wang H; Eder A; Mao M; Swaby R; Cheng K W; Stokoe D; Siminovitch K; Jaffe R; Gray J
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology 2001;28(5 Suppl 16):125-41.
2001: Aytac U; Claret F X; Ho L; Sato K; Ohnuma K; Mills G B; Cabanillas F; Morimoto C; Dang N H
Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint.
Cancer research 2001;61(19):7204-10.
2001: Mills G B; Lu Y; Kohn E C
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10031-3.
2001: Shridhar V; Lee J; Pandita A; Iturria S; Avula R; Staub J; Morrissey M; Calhoun E; Sen A; Kalli K; Keeney G; Roche P; Cliby W; Lu K; Schmandt R; Mills G B; Bast R C; James C D; Couch F J; Hartmann L C; Lillie J; Smith D I
Genetic analysis of early- versus late-stage ovarian tumors.
Cancer research 2001;61(15):5895-904.
2001: Liu B; Fang M; Lu Y; Lu Y; Mills G B; Fan Z
Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
British journal of cancer 2001;85(2):303-11.
2001: Mujoo K; Haridas V; Hoffmann J J; Wächter G A; Hutter L K; Lu Y; Blake M E; Jayatilake G S; Bailey D; Mills G B; Gutterman J U
Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
Cancer research 2001;61(14):5486-90.
2001: Ho L; Aytac U; Stephens L C; Ohnuma K; Mills G B; McKee K S; Neumann C; LaPushin R; Cabanillas F; Abbruzzese J L; Morimoto C; Dang N H
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2031-40.
2001: Cuevas B D; Lu Y; Mao M; Zhang J; LaPushin R; Siminovitch K; Mills G B
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(29):27455-61.
2001: Erickson J R; Hasegawa Y; Fang X; Eder A; Mao M; Furui T; Aoki J; Morris A; Mills G B
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
2000: Kruzelock R P; Cuevas B D; Wiener J R; Xu F J; Yu Y; Cabeza-Arvelaiz Y; Pershouse M; Lovell M M; Killary A M; Mills G B; Bast R C
Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
Oncogene 2000;19(54):6277-85.
2000: Mao M; Fang X; Lu Y; Lapushin R; Bast R C; Mills G B
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
The Biochemical journal 2000;352 Pt 2():475-82.
2000: Fang X; Yu S; LaPushin R; Lu Y; Furui T; Penn L Z; Stokoe D; Erickson J R; Bast R C; Mills G B
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
The Biochemical journal 2000;352 Pt 1():135-43.
2000: Fang X; Yu S X; Lu Y; Bast R C; Woodgett J R; Mills G B
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11960-5.
2000: Le X F; Vadlamudi R; McWatters A; Bae D S; Mills G B; Kumar R; Bast R C
Differential signaling by an anti-p185(HER2) antibody and heregulin.
Cancer research 2000;60(13):3522-31.
2000: Eder A M; Sasagawa T; Mao M; Aoki J; Mills G B
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2482-91.
2000: Fang X; Gaudette D; Furui T; Mao M; Estrella V; Eder A; Pustilnik T; Sasagawa T; Lapushin R; Yu S; Jaffe R B; Wiener J R; Erickson J R; Mills G B
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Annals of the New York Academy of Sciences 2000;905():188-208.
2000: Ramondetta L; Mills G B; Burke T W; Wolf J K
Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):278-84.
2000: Le X F; McWatters A; Wiener J; Wu J Y; Mills G B; Bast R C
Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):260-70.
1999: Furui T; LaPushin R; Mao M; Khan H; Watt S R; Watt M A; Lu Y; Fang X; Tsutsui S; Siddik Z H; Bast R C; Mills G B
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4308-18.
1999: Gershenson D M; Deavers M; Diaz S; Tortolero-Luna G; Miller B E; Bast R C; Mills G B; Silva E G
Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4053-8.
1999: Lu Y; Lin Y Z; LaPushin R; Cuevas B; Fang X; Yu S X; Davies M A; Khan H; Furui T; Mao M; Zinner R; Hung M C; Steck P; Siminovitch K; Mills G B
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
1999: Fang X; Yu S; Eder A; Mao M; Bast R C; Boyd D; Mills G B
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway.
Oncogene 1999;18(48):6635-40.
1999: Pustilnik T B; Estrella V; Wiener J R; Mao M; Eder A; Watt M A; Bast R C; Mills G B
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3704-10.
1999: Xu F; Yu Y; Le X F; Boyer C; Mills G B; Bast R C
The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3653-60.
1999: Wolf J K; Mills G B; Bazzet L; Bast R C; Roth J A; Gershenson D M
Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
Gynecologic oncology 1999;75(2):261-6.
1999: Cuevas B; Lu Y; Watt S; Kumar R; Zhang J; Siminovitch K A; Mills G B
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
The Journal of biological chemistry 1999;274(39):27583-9.
1999: Zebrowski B K; Liu W; Ramirez K; Akagi Y; Mills G B; Ellis L M
Markedly elevated levels of vascular endothelial growth factor in malignant ascites.
Annals of surgical oncology 1999;6(4):373-8.
1999: Hagopian G S; Mills G B; Khokhar A R; Bast R C; Siddik Z H
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):655-63.
1999: Yu Y; Xu F; Peng H; Fang X; Zhao S; Li Y; Cuevas B; Kuo W L; Gray J W; Siciliano M; Mills G B; Bast R C
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):214-9.
1998: Davies M A; Lu Y; Sano T; Fang X; Tang P; LaPushin R; Koul D; Bookstein R; Stokoe D; Yung W K; Mills G B; Steck P A
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.
1998: Lu Y; Cuevas B; Gibson S; Khan H; LaPushin R; Imboden J; Mills G B
Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5404-12.
1998: Bast R C; Xu F J; Yu Y H; Barnhill S; Zhang Z; Mills G B
CA 125: the past and the future.
The International journal of biological markers 1998;13(4):179-87.
1998: Koul D; Obeyesekere N U; Gutterman J U; Mills G B; Choubey D
p202 self-associates through a sequence conserved among the members of the 200-family proteins.
FEBS letters 1998;438(1-2):21-4.
1998: Koul D; Lapushin R; Xu H J; Mills G B; Gutterman J U; Choubey D
p202 prevents apoptosis in murine AKR-2B fibroblasts.
Biochemical and biophysical research communications 1998;247(2):379-82.
1998: Gibson S; Truitt K; Lu Y; Lapushin R; Khan H; Imboden J B; Mills G B
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
The Biochemical journal 1998;330 ( Pt 3)():1123-8.
1998: Fang X; Jin X; Xu H J; Liu L; Peng H Q; Hogg D; Roth J A; Yu Y; Xu F; Bast R C; Mills G B
Expression of p16 induces transcriptional downregulation of the RB gene.
Oncogene 1998;16(1):1-8.
1997: Teng D H; Hu R; Lin H; Davis T; Iliev D; Frye C; Swedlund B; Hansen K L; Vinson V L; Gumpper K L; Ellis L; El-Naggar A; Frazier M; Jasser S; Langford L A; Lee J; Mills G B; Pershouse M A; Pollack R E; Tornos C; Troncoso P; Yung W K; Fujii G; Berson A; Steck P A
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Cancer research 1997;57(23):5221-5.
1997: Xu H J; Zhou Y; Ji W; Perng G S; Kruzelock R; Kong C T; Bast R C; Mills G B; Li J; Hu S X
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition.
Oncogene 1997;15(21):2589-96.
1997: Xu F J; Stack S; Boyer C; O'Briant K; Whitaker R; Mills G B; Yu Y H; Bast R C
Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1629-34.
1997: Fang X; Gibson S; Flowers M; Furui T; Bast R C; Mills G B
Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
The Journal of biological chemistry 1997;272(21):13683-9.
1996: Gibson S; August A; Kawakami Y; Kawakami T; Dupont B; Mills G B
The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2716-22.
1995: Truitt K E; Shi J; Gibson S; Segal L G; Mills G B; Imboden J B
CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4702-10.
1995: Goldsmith M A; Lai S Y; Xu W; Amaral M C; Kuczek E S; Parent L J; Mills G B; Tarr K L; Longmore G D; Greene W C
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
The Journal of biological chemistry 1995;270(37):21729-37.
1994: Truitt K E; Mills G B; Turck C W; Imboden J B
SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
The Journal of biological chemistry 1994;269(8):5937-43.

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