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Leonid Minakhin

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Vladimir Mekler; Leonid Minakhin; Damir Mukhamedyarov; Konstantin Kuznedelov; Konstantin Severinov
RNA polymerase-promoter interactions determining different stability of the Escherichia coli and Thermus aquaticus transcription initiation complexes.
Zhanna Berdygulova; Daria Esyunina; Andrey Kulbachinskiy; Konstantin Kuznedelov; Nataliya Miropolskaya; Damir Mukhamedyarov; Bryce E Nickels; Konstantin Severinov; Leonid Minakhin
A novel phage-encoded transcription antiterminator acts by suppressing bacterial RNA polymerase pausing.
Vladimir Mekler; Leonid Minakhin; Carol Sheppard; Sivaramesh Wigneshweraraj; Konstantin Severinov
Molecular mechanism of transcription inhibition by phage T7 gp2 protein.

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All Publications

2012: Vladimir Mekler; Leonid Minakhin; Damir Mukhamedyarov; Konstantin Kuznedelov; Konstantin Severinov
RNA polymerase-promoter interactions determining different stability of the Escherichia coli and Thermus aquaticus transcription initiation complexes.
Nucleic acids research 2012;40(22):11352-62.
2012: Zhanna Berdygulova; Daria Esyunina; Andrey Kulbachinskiy; Konstantin Kuznedelov; Nataliya Miropolskaya; Damir Mukhamedyarov; Bryce E Nickels; Konstantin Severinov; Leonid Minakhin
A novel phage-encoded transcription antiterminator acts by suppressing bacterial RNA polymerase pausing.
Nucleic acids research 2012;40(9):4052-63.
2011: Vladimir Mekler; Leonid Minakhin; Carol Sheppard; Sivaramesh Wigneshweraraj; Konstantin Severinov
Molecular mechanism of transcription inhibition by phage T7 gp2 protein.
Journal of molecular biology 2011;413(5):1016-27.
2011: Vladimir Mekler; Leonid Minakhin; Konstantin Severinov
A critical role of downstream RNA polymerase-promoter interactions in the formation of initiation complex.
The Journal of biological chemistry 2011;286(25):22600-8.
2011: Zhanna Berdygulova; Lars F Westblade; Laurence Florens; Eugene V Koonin; Brian T Chait; Erlan Ramanculov; Michael Washburn; Seth A Darst; Konstantin Severinov; Leonid Minakhin
Temporal regulation of gene expression of the Thermus thermophilus bacteriophage P23-45.
Journal of molecular biology 2011;405(1):125-42.
2010: Joshua M Gilmore; Ramona J Bieber Urbauer; Leonid Minakhin; Vladimir Akoyev; Michal Zolkiewski; Konstantin Severinov; Jeffrey L Urbauer
Determinants of affinity and activity of the anti-sigma factor AsiA.
Biochemistry 2010;49(29):6143-54.
2008: Leonid Minakhin; Manisha Goel; Zhanna Berdygulova; Erlan Ramanculov; Laurence Florens; Galina Glazko; Valeri N Karamychev; Alexei I Slesarev; Sergei A Kozyavkin; Igor Khromov; Hans-W Ackermann; Michael Washburn; Arcady Mushegian; Konstantin Severinov
Genome comparison and proteomic characterization of Thermus thermophilus bacteriophages P23-45 and P74-26: siphoviruses with triplex-forming sequences and the longest known tails.
Journal of molecular biology 2008;378(2):468-80.
2008: Lars F Westblade; Leonid Minakhin; Konstantin Kuznedelov; Alan J Tackett; Emmanuel J Chang; Rachel A Mooney; Irina Vvedenskaya; Qing Jun Wang; David Fenyö; Michael P Rout; Robert Landick; Brian T Chait; Konstantin Severinov; Seth A Darst
Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions.
Journal of proteome research 2008;7(3):1244-50.
2007: Anastasiya Sevostyanova; Marko Djordjevic; Konstantin Kuznedelov; Tatyana Naryshkina; Mikhail S Gelfand; Konstantin Severinov; Leonid Minakhin
Temporal regulation of viral transcription during development of Thermus thermophilus bacteriophage phiYS40.
Journal of molecular biology 2007;366(2):420-35.
2006: Tatyana Naryshkina; Jing Liu; Laurence Florens; Selene K Swanson; Andrey R Pavlov; Nadejda Pavlova; Ross Inman; Leonid Minakhin; Sergei A Kozyavkin; Michael Washburn; Arcady Mushegian; Konstantin Severinov
Thermus thermophilus bacteriophage phiYS40 genome and proteomic characterization of virions.
Journal of molecular biology 2006;364(4):667-77.
2006: Kimberly Baxter; Jennifer Lee; Leonid Minakhin; Konstantin Severinov; Deborah M Hinton
Mutational analysis of sigma70 region 4 needed for appropriation by the bacteriophage T4 transcription factors AsiA and MotA.
Journal of molecular biology 2006;363(5):931-44.
2005: Sofia Mindlin; Leonid Minakhin; Mayya Petrova; Gennady Kholodii; Svetlana Minakhina; Zhosefine Gorlenko; Vadim Nikiforov
Present-day mercury resistance transposons are common in bacteria preserved in permafrost grounds since the Upper Pleistocene.
Research in microbiology 2005;156(10):994-1004.
2005: Leonid Minakhin; Ekaterina Semenova; Jing Liu; Anatoly Vasilov; Elena Severinova; Tarasii Gabisonia; Ross Inman; Arcady Mushegian; Konstantin Severinov
Genome sequence and gene expression of Bacillus anthracis bacteriophage Fah.
Journal of molecular biology 2005;354(1):1-15.
2005: Leonid Minakhin; Konstantin Severinov
Transcription regulation by bacteriophage T4 AsiA.
Protein expression and purification 2005;41(1):1-8.
2005: Bryce E Nickels; Sean J Garrity; Vladimir Mekler; Leonid Minakhin; Konstantin Severinov; Richard H. Ebright; Ann Hochschild
The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4488-93.
2005: Ekaterina Semenova; Leonid Minakhin; Ekaterina Bogdanova; Maxim Nagornykh; Anatoliy Vasilov; Tomasz Heyduk; Alexander S Solonin; Marina Zakharova; Konstantin Severinov
Transcription regulation of the EcoRV restriction-modification system.
Nucleic acids research 2005;33(21):6942-51.
2004: Brian D Gregory; Bryce E Nickels; Sean J Garrity; Elena Severinova; Leonid Minakhin; Ramona J Bieber Urbauer; Jeffrey L Urbauer; Tomasz Heyduk; Konstantin Severinov; Ann Hochschild
A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4554-9.
2004: Marina Zakharova; Leonid Minakhin; Alexander S Solonin; Konstantin Severinov
Regulation of RNA polymerase promoter selectivity by covalent modification of DNA.
Journal of molecular biology 2004;335(1):103-11.
2003: Leonid Minakhin; Konstantin Severinov
On the role of the Escherichia coli RNA polymerase sigma 70 region 4.2 and alpha-subunit C-terminal domains in promoter complex formation on the extended -10 galP1 promoter.
The Journal of biological chemistry 2003;278(32):29710-8.
2003: Mario F Simeonov; Ramona J Bieber Urbauer; Joshua M Gilmore; Karen Adelman; Edward N Brody; Anita Niedziela-Majka; Leonid Minakhin; Tomasz Heyduk; Jeffrey L Urbauer
Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.
Biochemistry 2003;42(25):7717-26.
2003: Leonid Minakhin; Anita Niedziela-Majka; Konstantin Kuznedelov; Karen Adelman; Jeffrey L Urbauer; Tomasz Heyduk; Konstantin Severinov
Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription.
Journal of molecular biology 2003;326(3):679-90.
2003: Konstantin Kuznedelov; Leonid Minakhin; Konstantin Severinov
Preparation and characterization of recombinant Thermus aquaticus RNA polymerase.
Methods in enzymology 2003;370():94-108.
2002: Konstantin Kuznedelov; Leonid Minakhin; Anita Niedziela-Majka; Simon L Dove; Dragana Rogulja; Bryce E Nickels; Ann Hochschild; Tomasz Heyduk; Konstantin Severinov
A role for interaction of the RNA polymerase flap domain with the sigma subunit in promoter recognition.
Science (New York, N.Y.) 2002;295(5556):855-7.
2001: Sofia Mindlin; Gennady Kholodii; Zhosefine Gorlenko; Svetlana Minakhina; Leonid Minakhin; Eza Kalyaeva; AV Kopteva; Mayya Petrova; OV Yurieva; Vadim Nikiforov
Mercury resistance transposons of gram-negative environmental bacteria and their classification.
Research in microbiology 2001;152(9):811-22.
2001: ES Bogdanova; Leonid Minakhin; Irina Bass; A Volodin; Jon Hobman; Vadim Nikiforov
Class II broad-spectrum mercury resistance transposons in Gram-positive bacteria from natural environments.
Research in microbiology 2001;152(5):503-14.
2001: Leonid Minakhin; S Bhagat; A Brunning; Elizabeth A Campbell; Seth A Darst; Richard H. Ebright; Konstantin Severinov
Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):892-7.
2001: Leonid Minakhin; S Nechaev; Elizabeth A Campbell; Konstantin Severinov
Recombinant Thermus aquaticus RNA polymerase, a new tool for structure-based analysis of transcription.
Journal of bacteriology 2001;183(1):71-6.
1999: G Zhang; Elizabeth A Campbell; Leonid Minakhin; C Richter; Konstantin Severinov; Seth A Darst
Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.
Cell 1999;98(6):811-24.
1999: Vadim Nikiforov; Irina Bass; ES Bogdanova; ES Kaliaeva; AV Kopteva; O L Lomovskaia; Leonid Minakhin; S V Minakhina; Sofia Mindlin; Mayya Petrova; G Ia Kholodiĭ; O V Iur'eva
[Distribution of mercury resistance transposons in natural bacteria populations].
Molekuliarnaia biologiia 1999;33(1):55-62.
1998: ES Bogdanova; Irina Bass; Leonid Minakhin; Mayya Petrova; Sofia Mindlin; A A Volodin; Eza Kalyaeva; James M Tiedje; Jon Hobman; Nigel Brown; Vadim Nikiforov
Horizontal spread of mer operons among gram-positive bacteria in natural environments.
Microbiology (Reading, England) 1998;144 ( Pt 3)():609-20.
1997: OV Yurieva; Gennady Kholodii; Leonid Minakhin; Zhosefine Gorlenko; Eza Kalyaeva; Sofia Mindlin; Vadim Nikiforov
Intercontinental spread of promiscuous mercury-resistance transposons in environmental bacteria.
Molecular microbiology 1997;24(2):321-9.