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Anna Minarini

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Structure-Activity Relationship

Chemicals & Drugs

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Drug Design

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Alzheimer's Disease

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Publications

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Andrea Milelli; Stefano Alcaro; Isabel Barasoain; Giovanna Bianchi; J Fernando Díaz; Marialuisa Micco; Federica Moraca; Caterina Musetti; Benet Pera; Vito Pistoia; Lizzia Raffaghello; Michela Rosini; Claudia Sissi; Claudio Stefanelli; Marianna Toniolo; Chiara Trigili; Vincenzo Tumiatti; Maddalena Zini; Guendalina Zuccari; Anna Minarini
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.
Anna Minarini; Vincenzo Tumiatti; Eleonora Turrini; Lorenzo Ferruzzi; Patrizia Hrelia; Melinda-Rita Marton; Andrea Milelli; Carmela Fimognari
Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.
Anna Minarini; E Motori; Michela Rosini; E Simoni; Vincenzo Tumiatti; Vincenza Andrisano; Cristina Angeloni; Manuela Bartolini; Maria Laura Bolognesi; A Milelli; Silvana Hrelia
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.

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All Publications

2012: Andrea Milelli; Stefano Alcaro; Isabel Barasoain; Giovanna Bianchi; J Fernando Díaz; Marialuisa Micco; Federica Moraca; Caterina Musetti; Benet Pera; Vito Pistoia; Lizzia Raffaghello; Michela Rosini; Claudia Sissi; Claudio Stefanelli; Marianna Toniolo; Chiara Trigili; Vincenzo Tumiatti; Maddalena Zini; Guendalina Zuccari; Anna Minarini
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.
European journal of medicinal chemistry 2012;57():417-28.
2012: Anna Minarini; Vincenzo Tumiatti; Eleonora Turrini; Lorenzo Ferruzzi; Patrizia Hrelia; Melinda-Rita Marton; Andrea Milelli; Carmela Fimognari
Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.
European journal of medicinal chemistry 2012;48():124-31.
2012: Anna Minarini; E Motori; Michela Rosini; E Simoni; Vincenzo Tumiatti; Vincenza Andrisano; Cristina Angeloni; Manuela Bartolini; Maria Laura Bolognesi; A Milelli; Silvana Hrelia
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.
Neuropharmacology 2012;62(2):997-1003.
2012: Bonaiuto Emanuela; Michele Lunelli; Andrea Milelli; Anna Minarini; Maurizio Pegoraro; Valeria Rizzoli; Vincenzo Tumiatti; Maria Luisa Di Paolo
Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study.
Amino acids 2012;42(2-3):913-28.
2011: Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Elena Simoni; Vincenzo Tumiatti; Carlo Melchiorre
Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.
Current topics in medicinal chemistry 2011;11(22):2797-806.
2011: Maria Laura Bolognesi; Manuela Bartolini; Andrea Tarozzi; Fabiana Morroni; Federica Lizzi; Andrea Milelli; Anna Minarini; Michela Rosini; Patrizia Hrelia; Vincenza Andrisano; Carlo Melchiorre
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.
Bioorganic & medicinal chemistry letters 2011;21(9):2655-8.
2010: Elena Simoni; Christian Bergamini; Romana Fato; Andrea Tarozzi; Sandip Bains; Roberto Motterlini; Andrea Cavalli; Maria Laura Bolognesi; Anna Minarini; Patrizia Hrelia; Giorgio Lenaz; Michela Rosini; Carlo Melchiorre
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents.
Journal of medicinal chemistry 2010;53(19):7264-8.
2010: Carlo Melchiorre; Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Vincenzo Tumiatti
Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.
Journal of medicinal chemistry 2010;53(16):5906-14.
2010: Anna Minarini; Andrea Milelli; Vincenzo Tumiatti; Michela Rosini; Maria Laura Bolognesi; Carlo Melchiorre
Synthetic polyamines: an overview of their multiple biological activities.
Amino acids 2010;38(2):383-92.
2010: Vincenzo Tumiatti; Anna Minarini; Maria Laura Bolognesi; A Milelli; Michela Rosini; Carlo Melchiorre
Tacrine derivatives and Alzheimer's disease.
Current medicinal chemistry 2010;17(17):1825-38.
2009: Vincenzo Tumiatti; Andrea Milelli; Anna Minarini; Marialuisa Micco; Anna Gasperi-Campani; Laura Roncuzzi; Daniela Baiocchi; Jessica Marinello; Giovanni Capranico; Maddalena Zini; Claudio Stefanelli; Carlo Melchiorre
Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.
Journal of medicinal chemistry 2009;52(23):7873-7.
2009: Maddalena Zini; Catherine L Passariello; Davide Gottardi; Silvia Cetrullo; Flavio Flamigni; Carla Pignatti; Anna Minarini; Vincenzo Tumiatti; Andrea Milelli; Carlo Melchiorre; Claudio Stefanelli
Cytotoxicity of methoctramine and methoctramine-related polyamines.
Chemico-biological interactions 2009;181(3):409-16.
2009: Maria L Bolognesi; Riccardo Matera; Anna Minarini; Michela Rosini; Carlo Melchiorre
Alzheimer's disease: new approaches to drug discovery.
Current opinion in chemical biology 2009;13(3):303-8.
2009: Maria Laura Bolognesi; Michela Rosini; Vincenza Andrisano; Manuela Bartolini; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
Current pharmaceutical design 2009;15(6):601-13.
2008: Vincenzo Tumiatti; Andrea Milelli; Anna Minarini; Michela Rosini; Maria Laura Bolognesi; Marialuisa Micco; Vincenza Andrisano; Manuela Bartolini; Francesca Mancini; Maurizio Recanatini; Andrea Cavalli; Carlo Melchiorre
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
Journal of medicinal chemistry 2008;51(22):7308-12.
2008: Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease.
Mini reviews in medicinal chemistry 2008;8(10):960-7.
2008: Michela Rosini; Elena Simoni; Manuela Bartolini; Andrea Cavalli; Luisa Ceccarini; Nicoleta Pascu; David W McClymont; Andrea Tarozzi; Maria L Bolognesi; Anna Minarini; Vincenzo Tumiatti; Vincenza Andrisano; Ian R Mellor; Carlo Melchiorre
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Journal of medicinal chemistry 2008;51(15):4381-4.
2008: Anna Minarini; Gabriella Marucci; Cristina Bellucci; Gianluca Giorgi; Vincenzo Tumiatti; Maria Laura Bolognesi; Riccardo Matera; Michela Rosini; Carlo Melchiorre
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.
Bioorganic & medicinal chemistry 2008;16(15):7311-20.
2008: Andrea Cavalli; Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Maurizio Recanatini; Carlo Melchiorre
Multi-target-directed ligands to combat neurodegenerative diseases.
Journal of medicinal chemistry 2008;51(3):347-72.
2007: Maria Laura Bolognesi; Rita Banzi; Manuela Bartolini; Andrea Cavalli; Andrea Tarozzi; Vincenza Andrisano; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Christian Bergamini; Romana Fato; Giorgio Lenaz; Patrizia Hrelia; Antonino Cattaneo; Maurizio Recanatini; Carlo Melchiorre
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Journal of medicinal chemistry 2007;50(20):4882-97.
2007: Vincenzo Tumiatti; Anna Minarini; Andrea Milelli; Michela Rosini; Michela Buccioni; Gabriella Marucci; Carla Ghelardini; Cristina Bellucci; Carlo Melchiorre
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.
Bioorganic & medicinal chemistry 2007;15(6):2312-21.
2007: Michela Rosini; Maria Laura Bolognesi; Dario Giardinà; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.
Current topics in medicinal chemistry 2007;7(2):147-62.
2006: Maria Laura Bolognesi; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.
Mini reviews in medicinal chemistry 2006;6(11):1269-74.
2006: Anna Minarini; Vincenzo Tumiatti; Maria Laura Bolognesi; Carlo Melchiorre
Recent advances in the design and synthesis of prazosin derivatives.
Expert opinion on drug discovery 2006;1(5):395-407.
2005: Maria Laura Bolognesi; Vincenza Andrisano; Manuela Bartolini; Andrea Cavalli; Anna Minarini; Maurizio Recanatini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
Heterocyclic inhibitors of AChE acylation and peripheral sites.
Farmaco (Società chimica italiana : 1989) 2005;60(6-7):465-73.
2005: Maria Grazia Gioia; Rita Gatti; Anna Minarini
LC determination of leuprolide component amino acids in injectable solution by phanquinone pre-column derivatization labelling procedure.
Journal of pharmaceutical and biomedical analysis 2005;37(5):1135-41.
2005: Michela Rosini; Vincenza Andrisano; Manuela Bartolini; Maria Laura Bolognesi; Patrizia Hrelia; Anna Minarini; Andrea Tarozzi; Carlo Melchiorre
Rational approach to discover multipotent anti-Alzheimer drugs.
Journal of medicinal chemistry 2005;48(2):360-3.
2004: Vincenzo Tumiatti; Vincenza Andrisano; Rita Banzi; Manuela Bartolini; Anna Minarini; Michela Rosini; Carlo Melchiorre
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Journal of medicinal chemistry 2004;47(26):6490-8.
2004: Ian R Mellor; Jane Ogilvie; Florentina Pluteanu; Richard H Clothier; Terence L Parker; Michela Rosini; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.
European journal of pharmacology 2004;505(1-3):37-50.
2004: Maria Laura Bolognesi; Manuela Bartolini; Andrea Cavalli; Vincenza Andrisano; Michela Rosini; Anna Minarini; Carlo Melchiorre
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.
Journal of medicinal chemistry 2004;47(24):5945-52.
2003: Michela Rosini; Alessandra Antonello; Andrea Cavalli; Maria Laura Bolognesi; Anna Minarini; Gabriella Marucci; Elena Poggesi; Amedeo Leonardi; Carlo Melchiorre
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Journal of medicinal chemistry 2003;46(23):4895-903.
2003: Vincenzo Tumiatti; Michela Rosini; Manuela Bartolini; Andrea Cavalli; Gabriella Marucci; Vincenza Andrisano; Piero Angeli; Rita Banzi; Anna Minarini; Maurizio Recanatini; Carlo Melchiorre
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry 2003;46(6):954-66.
2003: Carlo Melchiorre; Alessandra Antonello; Rita Banzi; Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Vincenzo Tumiatti
Polymethylene tetraamine backbone as template for the development of biologically active polyamines.
Medicinal research reviews 2003;23(2):200-33.
2002: Michela Rosini; M Gabriele Bixel; Gabriella Marucci; Roberta Budriesi; Michael Krauss; Maria Laura Bolognesi; Anna Minarini; Vincenzo Tumiatti; Ferdinand Hucho; Carlo Melchiorre
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
Journal of medicinal chemistry 2002;45(9):1860-78.
2001: Carlo Melchiorre; Maria Laura Bolognesi; Roberta Budriesi; Carla Ghelardini; Alberto Chiarini; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; E J Wade
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Journal of medicinal chemistry 2001;44(24):4035-8.
2001: Roberta Budriesi; S Cacciaguerra; R D Toro; Maria Laura Bolognesi; Alberto Chiarini; Anna Minarini; Michela Rosini; santi spampinato; Vincenzo Tumiatti; Carlo Melchiorre
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines.
British journal of pharmacology 2001;132(5):1009-16.
2001: Maria Laura Bolognesi; Gabriella Marucci; Piero Angeli; Michela Buccioni; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.
Journal of medicinal chemistry 2001;44(3):362-71.
2001: Maria Laura Bolognesi; Vincenza Andrisano; Manuela Bartolini; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
Journal of medicinal chemistry 2001;44(1):105-9.
2000: Vincenzo Tumiatti; Piero Angeli; Vincenza Andrisano; Maria Laura Bolognesi; Andrea Cavalli; Gabriella Marucci; Anna Minarini; Maurizio Recanatini; Michela Rosini; Carlo Melchiorre
[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors.
Bioorganic & medicinal chemistry 2000;8(4):681-9.
2000: Carlo Melchiorre; Piero Angeli; Maria Laura Bolognesi; Alberto Chiarini; Dario Giardinà; Ugo Gulini; Amedeo Leonardi; Gabriella Marucci; Anna Minarini; Maria Pigini; Wilma Quaglia; Michela Rosini; Vincenzo Tumiatti
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety.
Pharmaceutica acta Helvetiae 2000;74(2-3):181-90.
1999: Michela Rosini; Roberta Budriesi; M Gabriele Bixel; Maria Laura Bolognesi; Alberto Chiarini; Ferdinand Hucho; P Krogsgaard-Larsen; Ian R Mellor; Anna Minarini; Vincenzo Tumiatti; Peter N R Usherwood; Carlo Melchiorre
Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
Journal of medicinal chemistry 1999;42(25):5212-23.
1999: Maria Laura Bolognesi; Roberta Budriesi; Andrea Cavalli; Alberto Chiarini; Roberto Gotti; Amedeo Leonardi; Anna Minarini; Elena Poggesi; Maurizio Recanatini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Journal of medicinal chemistry 1999;42(20):4214-24.
1998: Maria Laura Bolognesi; Anna Minarini; Roberta Budriesi; S Cacciaguerra; Alberto Chiarini; santi spampinato; Vincenzo Tumiatti; Carlo Melchiorre
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
Journal of medicinal chemistry 1998;41(21):4150-60.
1998: Pascaline VAEZ-OLIVERA; A Colelli; M L Bolognesi; Anna Minarini; Vincenzo Tumiatti; Giovanni U Corsini; Carlo Melchiorre; Roberto Maggio
Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor.
European journal of pharmacology 1998;355(2-3):267-74.
1998: Anna Minarini; Roberta Budriesi; Alberto Chiarini; Amedeo Leonardi; Carlo Melchiorre
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
Bioorganic & medicinal chemistry letters 1998;8(11):1353-8.
1998: Carlo Melchiorre; Maria Laura Bolognesi; Roberta Budriesi; Alberto Chiarini; Dario Giardinà; Anna Minarini; Wilma Quaglia; Amedeo Leonardi
Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?
Farmaco (Società chimica italiana : 1989) 1998;53(4):278-86.
1995: Alberto Chiarini; Roberta Budriesi; M L Bolognesi; Anna Minarini; Carlo Melchiorre
In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.
British journal of pharmacology 1995;114(7):1507-17.
1995: Carlo Melchiorre; Anna Minarini; Roberta Budriesi; Alberto Chiarini; santi spampinato; Vincenzo Tumiatti
The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
Life sciences 1995;56(11-12):837-44.
1994: Anna Minarini; M L Bolognesi; Roberta Budriesi; Marco Canossa; Alberto Chiarini; santi spampinato; Carlo Melchiorre
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines.
Journal of medicinal chemistry 1994;37(20):3363-72.
1994: Roberto Maggio; Pascaline VAEZ-OLIVERA; M L Bolognesi; Anna Minarini; D Tedeschi; Carlo Melchiorre
Binding profile of the selective muscarinic receptor antagonist tripitramine.
European journal of pharmacology 1994;268(3):459-62.
1993: Carlo Melchiorre; M L Bolognesi; Alberto Chiarini; Anna Minarini; santi spampinato
Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.
Journal of medicinal chemistry 1993;36(23):3734-7.
1992: Maurizio Recanatini; Anna Minarini; Carlo Melchiorre; Roberta Budriesi; M L Bolognesi
Affinity and selectivity at M2 and M3 muscarinic receptor subtypes of cyclic and oxygenated analogues of 4-DAMP.
Farmaco (Società chimica italiana : 1989) 1992;47(9):1133-47.
1991: Anna Minarini; Roberta Budriesi; Alberto Chiarini; Carlo Melchiorre; Vincenzo Tumiatti
Further investigation on methoctramine-related tetraamines: effects of terminal N-substitution and of chain length separating the four nitrogens on M2 muscarinic receptor blocking activity.
Farmaco (Società chimica italiana : 1989) 1991;46(10):1167-78.
1991: Wilma Quaglia; Dario Giardinà; Gabriella Marucci; Carlo Melchiorre; Anna Minarini; Vincenzo Tumiatti
Structure-activity relationships among methoctramine-related polymethylene tetraamines. 3. Effect of the four nitrogens on M2 muscarinic blocking activity as revealed by symmetrical and unsymmetrical polyamines.
Farmaco (Società chimica italiana : 1989) 1991;46(3):417-34.
1990: Alberto Chiarini; Anna Minarini; Roberta Budriesi; Carlo Melchiorre
Molecular properties of the histamine H2-receptor. Covalent inhibition by tetraamine disulfides.
Farmaco (Società chimica italiana : 1989) 1990;45(9):1001-11.
1989: Carlo Melchiorre; Anna Minarini; Piero Angeli; Dario Giardinà; U Gulini; Wilma Quaglia
Polymethylene tetraamines as muscarinic receptor probes.
Trends in pharmacological sciences 1989;Suppl():55-9.