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George Minasov

Research Profile

Procedures

X Ray Crystallography

Concepts & Ideas

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Physiology

Mutagenesis, Site-Directed

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Thermodynamics

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Publications

TOP 3
Ekaterina V Filippova; Alexandra M Gehring; Brett Geissler; Chinessa T Adkins; Wayne F Anderson; Nicola Armoush; Daniel P Becker; Ievgeniia Dubrovska; Misty L Kuhn; Luke D Lavis; George Minasov; Karla J Fullner Satchell; Ludmilla Shuvalova; Leigh A Weston; James R Winsor; R Jeremy Johnson
Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis.
Andrei S Halavaty; Andrzej Joachimiak; Youngchang Kim; Keehwan Kwon; George Minasov; Olena Onopriyenko; Leka Papazisi; Scott N Peterson; Alexei Savchenko; Ludmilla Shuvalova; Tatiana Skarina; James Winsor; Min Zhou; Ievgeniia Dubrovska; Wayne F Anderson
Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.
Samuel H Light; George Minasov; Ludmilla Shuvalova; Andrei S Halavaty; Wayne F Anderson
Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain.

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All Publications

2013: Ekaterina V Filippova; Alexandra M Gehring; Brett Geissler; Chinessa T Adkins; Wayne F Anderson; Nicola Armoush; Daniel P Becker; Ievgeniia Dubrovska; Misty L Kuhn; Luke D Lavis; George Minasov; Karla J Fullner Satchell; Ludmilla Shuvalova; Leigh A Weston; James R Winsor; R Jeremy Johnson
Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis.
The Journal of biological chemistry 2013;288(15):10522-35.
2012: Andrei S Halavaty; Andrzej Joachimiak; Youngchang Kim; Keehwan Kwon; George Minasov; Olena Onopriyenko; Leka Papazisi; Scott N Peterson; Alexei Savchenko; Ludmilla Shuvalova; Tatiana Skarina; James Winsor; Min Zhou; Ievgeniia Dubrovska; Wayne F Anderson
Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 10):1359-70.
2012: Samuel H Light; George Minasov; Ludmilla Shuvalova; Andrei S Halavaty; Wayne F Anderson
Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain.
Protein science : a publication of the Protein Society 2012;21(6):887-95.
2012: Andrei S Halavaty; Alan R Hauser; George Minasov; Zbyszek Otwinowski; Ludmilla Shuvalova; Gregory H Tyson; Jeff L Veesenmeyer; Dominika Borek; Wayne F Anderson
Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU.
PloS one 2012;7(11):e49388.
2011: Ivan I Vorontsov; Joseph S. Brunzelle; Olga Kiryukhina; George Minasov; Ludmilla Shuvalova; Wayne F Anderson
Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex.
The Journal of biological chemistry 2011;286(38):33158-66.
2011: E V Filippova; Andrzej Joachimiak; O Kiryukhina; George Minasov; I Radhakrishnan; Ludmilla Shuvalova; Y Zhang; S Clancy; Wayne F Anderson
Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins 2011;79(8):2566-77.
2011: Samuel H Light; George Minasov; Ludmilla Shuvalova; Scott N Peterson; Michael Caffrey; Wayne F Anderson; Arnon Lavie
A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding.
Biochemistry 2011;50(12):2357-63.
2011: Samuel H Light; George Minasov; Ludmilla Shuvalova; Mark-Eugene Duban; Michael Caffrey; Wayne F Anderson; Arnon Lavie
Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.
The Journal of biological chemistry 2011;286(5):3531-9.
2009: Katerina Prochazkova; Ludmilla Shuvalova; George Minasov; Zdenek Voburka; Wayne F Anderson; Karla J Fullner Satchell
Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites.
The Journal of biological chemistry 2009;284(39):26557-68.
2009: George Minasov; Sivaraman Padavattan; Ludmilla Shuvalova; Joseph S. Brunzelle; Darcie J Miller; Arnaud Baslé; Claudia Massa; Frank R Collart; Tilman Schirmer; Wayne F Anderson
Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains.
The Journal of biological chemistry 2009;284(19):13174-84.
2007: Ivan I Vorontsov; George Minasov; Joseph S. Brunzelle; Ludmilla Shuvalova; Olga Kiryukhina; Frank Collart; Wayne F Anderson
Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity.
Protein science : a publication of the Protein Society 2007;16(11):2483-90.
2007: Michael Godsey; George Minasov; Ludmilla Shuvalova; Joseph S. Brunzelle; Ivan I Vorontsov; Frank Collart; Wayne F Anderson
The 2.2 A resolution crystal structure of Bacillus cereus Nif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain.
Protein science : a publication of the Protein Society 2007;16(7):1285-93.
2006: Martin Egli; Pradeep S Pallan; Rekha Pattanayek; Christopher J Wilds; Paolo Lubini; George Minasov; Max Dobler; Christian J Leumann; Albert Eschenmoser
Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system.
Journal of the American Chemical Society 2006;128(33):10847-56.
2006: Yu Chen; George Minasov; Tomer A Roth; Fabio Prati; Brian Shoichet
The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution.
Journal of the American Chemical Society 2006;128(9):2970-6.
2005: Martin Egli; George Minasov; Valentina Tereshko; Pradeep S Pallan; Marianna Teplova; Gopal B Inamati; Elena A Lesnik; Steve R Owens; Bruce S Ross; Thazha P Prakash; Muthiah Manoharan
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry 2005;44(25):9045-57.
2004: Hideki Kusunoki; George Minasov; Ruby I MacDonald; Alfonso Mondragón
Independent movement, dimerization and stability of tandem repeats of chicken brain alpha-spectrin.
Journal of molecular biology 2004;344(2):495-511.
2003: Tomer A Roth; George Minasov; Stefania Morandi; Fabio Prati; Brian Shoichet
Thermodynamic cycle analysis and inhibitor design against beta-lactamase.
Biochemistry 2003;42(49):14483-91.
2003: Samy O Meroueh; George Minasov; Wenlin Lee; Brian Shoichet; Shahriar Mobashery
Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.
Journal of the American Chemical Society 2003;125(32):9612-8.
2003: Xiaojun Wang; George Minasov; Jesús Blázquez; Emilia Caselli; Fabio Prati; Brian Shoichet
Recognition and resistance in TEM beta-lactamase.
Biochemistry 2003;42(28):8434-44.
2003: Marija Prhavc; Thazha P Prakash; George Minasov; P Dan Cook; Martin Egli; Muthiah Manoharan
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.
Organic letters 2003;5(12):2017-20.
2002: Xiaojun Wang; George Minasov; Brian Shoichet
The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.
The Journal of biological chemistry 2002;277(35):32149-56.
2002: Ursula D Ramirez; George Minasov; Pamela J Focia; Robert M Stroud; Peter Walter; Peter Kuhn; Douglas Freymann
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.
Journal of molecular biology 2002;320(4):783-99.
2002: Xiaojun Wang; George Minasov; Brian Shoichet
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
Journal of molecular biology 2002;320(1):85-95.
2002: George Minasov; Xiaojun Wang; Brian Shoichet
An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation.
Journal of the American Chemical Society 2002;124(19):5333-40.
2002: Martin Egli; George Minasov; Li Su; Alexander Rich
Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4302-7.
2002: Xiaojun Wang; George Minasov; Brian Shoichet
Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams.
Proteins 2002;47(1):86-96.
2001: Christopher J Wilds; George Minasov; F Natt; Peter von Matt; Karl-Heinz Altmann; Martin Egli
Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):991-4.
2001: Valentina Tereshko; Christopher J Wilds; George Minasov; Thazha P Prakash; Martin A Maier; A Howard; Zdzislaw Wawrzak; Muthiah Manoharan; Martin Egli
Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic acids research 2001;29(5):1208-15.
2000: George Minasov; Jasenka Matulic-Adamic; Christopher J Wilds; Peter Haeberli; N Usman; Leonid Beigelman; Martin Egli
Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.
RNA (New York, N.Y.) 2000;6(11):1516-28.
2000: George Minasov; Marianna Teplova; G C Stewart; E V Koonin; Wayne F Anderson; Martin Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6328-33.
2000: George Minasov; Marianna Teplova; P Nielsen; J Wengel; Martin Egli
Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA.
Biochemistry 2000;39(13):3525-32.
1999: Marianna Teplova; S T Wallace; Valentina Tereshko; George Minasov; AM Symons; P Dan Cook; Muthiah Manoharan; Martin Egli
Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14240-5.
1999: George Minasov; Valentina Tereshko; Martin Egli
Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing.
Journal of molecular biology 1999;291(1):83-99.
1999: Marianna Teplova; George Minasov; Valentina Tereshko; Gopal B Inamati; P Dan Cook; Muthiah Manoharan; Martin Egli
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nature structural biology 1999;6(6):535-9.
1998: Martin Egli; Valentina Tereshko; Marianna Teplova; George Minasov; Andrzej Joachimiak; Ruslan Sanishvili; C M Weeks; R Miller; Martin A Maier; H An; P Dan Cook; Muthiah Manoharan
X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution.
Biopolymers 1998;48(4):234-52.