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Marie-Paule Mingeot-Leclercq

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Co-Publications
Name
60
Tulkens, Paul
45
Van Bambeke, Françoise
20
Brasseur, Robert
13
Schanck, André
10
Dufrêne, Yves
7
Chanteux, Hugues
6
Carryn, Stéphane
6
Lemaire, Sandrine
6
Seral, Cristina
5
Tyteca, Donatienne
5
Van Der Smissen, Patrick
5
Courtoy, Pierre
4
Deleu, Magali
4
Michot, Jean-Michel
4
Barcia-Macay, Maritza

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Publications

TOP 3
Domenech Oscar; Francius Grégory; Tulkens Paul M; Van Bambeke Françoise; Dufrêne Yves; Mingeot-Leclercq Marie-Paule
Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization.
Marquez Béatrice; Caceres Nancy E; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
Francius Grégory; Domenech Oscar; Mingeot-Leclercq Marie Paule; Dufrêne Yves F
Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin.

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All Publications

2009: Domenech Oscar; Francius Grégory; Tulkens Paul M; Van Bambeke Françoise; Dufrêne Yves; Mingeot-Leclercq Marie-Paule
Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization.
Biochimica et biophysica acta 2009;1788(9):1832-40.
2009: Marquez Béatrice; Caceres Nancy E; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
Antimicrobial agents and chemotherapy 2009;53(6):2410-6.
2008: Francius Grégory; Domenech Oscar; Mingeot-Leclercq Marie Paule; Dufrêne Yves F
Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin.
Journal of bacteriology 2008;190(24):7904-9.
2008: Bensikaddour Hayet; Snoussi Karim; Lins Laurence; Van Bambeke Françoise; Tulkens Paul M; Brasseur Robert; Goormaghtigh Erik; Mingeot-Leclercq Marie-Paule
Interactions of ciprofloxacin with DPPC and DPPG: fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis.
Biochimica et biophysica acta 2008;1778(11):2535-43.
2008: Francius Grégory; Dufour Samuel; Deleu Magali; Paquot Michel; Mingeot-Leclercq Marie-Paule; Dufrêne Yves F
Nanoscale membrane activity of surfactins: influence of geometry, charge and hydrophobicity.
Biochimica et biophysica acta 2008;1778(10):2058-68.
2008: Lismond Ann; Tulkens Paul M; Mingeot-Leclercq Marie-Paule; Courvalin Patrice; Van Bambeke Françoise
Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes: studies with ciprofloxacin and moxifloxacin.
Antimicrobial agents and chemotherapy 2008;52(9):3040-6.
2008: Denamur Sophie; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.
Antimicrobial agents and chemotherapy 2008;52(6):2236-8.
2008: Barcia-Macay Maritza; Mouaden Fatima; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).
The Journal of antimicrobial chemotherapy 2008;61(6):1288-94.
2008: Bensikaddour Hayet; Fa Nathalie; Burton Ingrid; Deleu Magali; Lins Laurence; Schanck André; Brasseur Robert; Dufrêne Yves F; Goormaghtigh Erik; Mingeot-Leclercq Marie-Paule
Characterization of the interactions between fluoroquinolone antibiotics and lipids: a multitechnique approach.
Biophysical journal 2008;94(8):3035-46.
2008: Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Struelens Marc J; Tulkens Paul M
The bacterial envelope as a target for novel anti-MRSA antibiotics.
Trends in pharmacological sciences 2008;29(3):124-34.
2008: Servais H; Ortiz A; Devuyst O; Denamur S; Tulkens P M; Mingeot-Leclercq M-P
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation.
Apoptosis : an international journal on programmed cell death 2008;13(1):11-32.
2008: Mingeot-Leclercq Marie-Paule; Deleu Magali; Brasseur Robert; Dufrêne Yves F
Atomic force microscopy of supported lipid bilayers.
Nature protocols 2008;3(10):1654-9.
2007: Avrain Laetitia; Garvey Mark; Mesaros Narcisa; Glupczynski Youri; Mingeot-Leclercq Marie-Paule; Piddock Laura J V; Tulkens Paul M; Vanhoof Raymond; Van Bambeke Françoise
Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.
The Journal of antimicrobial chemotherapy 2007;60(5):965-72.
2007: Brasseur Robert; Braun Nathalie; El Kirat Karim; Deleu Magali; Mingeot-Leclercq Marie-Paule; Dufrêne Yves F
The biologically important surfactin lipopeptide induces nanoripples in supported lipid bilayers.
Langmuir : the ACS journal of surfaces and colloids 2007;23(19):9769-72.
2007: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.
Antimicrobial agents and chemotherapy 2007;51(8):2748-57.
2007: Fa N; Lins L; Courtoy P J; Dufrêne Y; Van Der Smissen P; Brasseur R; Tyteca D; Mingeot-Leclercq M-P
Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin.
Biochimica et biophysica acta 2007;1768(7):1830-8.
2007: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Glupczynski Youri; Tulkens Paul M
Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
Antimicrobial agents and chemotherapy 2007;51(5):1627-32.
2007: Baudoux Pierre; Bles Nathalie; Lemaire Sandrine; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.
The Journal of antimicrobial chemotherapy 2007;59(2):246-53.
2006: Barcia-Macay Maritza; Lemaire Sandrine; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2006;58(6):1177-84.
2006: Fa N; Ronkart S; Schanck A; Deleu M; Gaigneaux A; Goormaghtigh E; Mingeot-Leclercq M-P
Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers.
Chemistry and physics of lipids 2006;144(1):108-16.
2006: Michot Jean-Michel; Heremans Marie F; Caceres Nancy E; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
Antimicrobial agents and chemotherapy 2006;50(5):1689-95.
2006: Servais Hélène; Jossin Yves; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.
Antimicrobial agents and chemotherapy 2006;50(4):1213-21.
2006: Barcia-Macay Maritza; Seral Cristina; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.
Antimicrobial agents and chemotherapy 2006;50(3):841-51.
2006: Charvalos Ekatherina; Tzatzarakis Manolis N; Van Bambeke Françoise; Tulkens Paul M; Tsatsakis Aristidis M; Tzanakakis George N; Mingeot-Leclercq Marie-Paule
Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.
The Journal of antimicrobial chemotherapy 2006;57(2):236-44.
2005: Servais Hélène; Van Der Smissen Patrick; Thirion Gaëtan; Van der Essen Gauthier; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria.
Toxicology and applied pharmacology 2005;206(3):321-33.
2005: Michot Jean-Michel; Seral Cristina; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages.
Antimicrobial agents and chemotherapy 2005;49(6):2429-37.
2005: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Activity of three {beta}-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2005;55(6):897-904.
2005: Van Bambeke Françoise; Saffran Jennifer; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation.
Antimicrobial agents and chemotherapy 2005;49(5):1695-700.
2005: Chanteux Hugues; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.
Antimicrobial agents and chemotherapy 2005;49(4):1279-88.
2005: Seral C; Barcia-Macay M; Mingeot-Leclercq M P; Tulkens P M; Van Bambeke F
Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.
The Journal of antimicrobial chemotherapy 2005;55(4):511-7.
2005: Berquand A; Fa N; Dufrêne Y F; Mingeot-Leclercq M P
Interaction of the macrolide antibiotic azithromycin with lipid bilayers: effect on membrane organization, fluidity, and permeability.
Pharmaceutical research 2005;22(3):465-75.
2005: Piret Jocelyne; Schanck André; Delfosse Sylvie; Van Bambeke Françoise; Kishore Bellamkonda K; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids.
Chemistry and physics of lipids 2005;133(1):1-15.
2004: Berquand A; Mingeot-Leclercq M-P; Dufrêne Y F
Real-time imaging of drug-membrane interactions by atomic force microscopy.
Biochimica et biophysica acta 2004;1664(2):198-205.
2004: Van Bambeke Françoise; Carryn Stéphane; Seral Cristina; Chanteux Hugues; Tyteca Donatienne; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.
Antimicrobial agents and chemotherapy 2004;48(8):2853-60.
2004: Michot Jean-Michel; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
Antimicrobial agents and chemotherapy 2004;48(7):2673-82.
2004: Ben Abdelaziz Halim; Lemaire Sandrine; Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria.
The Journal of antimicrobial chemotherapy 2004;54(1):288-9.
2004: Carryn Stéphane; Van de Velde Sébastien; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide.
The Journal of infectious diseases 2004;189(11):2101-9.
2004: Nassogne Marie-Cécile; Lizarraga Chantal; N'Kuli Francisca; Van Bambeke Françoise; Van Binst Roger; Wallemacq Pierre; Tulkens Paul M; Mingeot-Leclercq Marie-Paule; Levade Thierry; Courtoy Pierre J
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Toxicology and applied pharmacology 2004;194(2):101-10.
2003: Chanteux Hugues; Mingeot-Leclercq Marie-Paule; Sonveaux Etienne; Van Bambeke Françoise; Tulkens Paul M
Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages.
The Journal of antimicrobial chemotherapy 2003;52(4):610-5.
2003: Carryn Stéphane; Chanteux Hugues; Seral Cristina; Mingeot-Leclercq Marie-Paule; Van Bambeke Françoise; Tulkens Paul M
Intracellular pharmacodynamics of antibiotics.
Infectious disease clinics of North America 2003;17(3):615-34.
2003: Tyteca D; Schanck A; Dufrêne Y F; Deleu M; Courtoy P J; Tulkens P M; Mingeot-Leclercq M P
The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages.
The Journal of membrane biology 2003;192(3):203-15.
2003: Chanteux Hugues; Paternotte Isabelle; Mingeot-Leclercq Marie-Paule; Brasseur Robert; Sonveaux E; Tulkens Paul M
Cell handling, membrane-binding properties, and membrane-penetration modeling approaches of pivampicillin and phthalimidomethylampicillin, two basic esters of ampicillin, in comparison with chloroquine and azithromycin.
Pharmaceutical research 2003;20(4):624-31.
2003: Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model.
The Journal of antimicrobial chemotherapy 2003;51(4):1051-2.
2003: Seral Cristina; Michot Jean-Michel; Chanteux Hugues; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Antimicrobial agents and chemotherapy 2003;47(3):1047-51.
2003: Dom Geneviève; Shaw-Jackson Chloë; Matis Christelle; Bouffioux Olivier; Picard Jacques J; Prochiantz Alain; Mingeot-Leclercq Marie-Paule; Brasseur Robert; Rezsohazy René
Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation.
Nucleic acids research 2003;31(2):556-61.
2003: Mingeot-Leclercq Marie-Paule; Lins Laurence; Bensliman Mariam; Thomas Annick; Van Bambeke Françoise; Peuvot Jacques; Schanck André; Brasseur Robert
Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.
Biochimica et biophysica acta 2003;1609(1):28-38.
2002: Mingeot-Leclercq Marie Paule; Lins Laurence; Bensliman Mariam; Van Bambeke Françoise; Van Der Smissen Patrick; Peuvot Jacques; Schanck André; Brasseur Robert
Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus.
Chemistry and physics of lipids 2002;120(1-2):57-74.
2002: Tyteca Donatienne; Van Der Smissen Patrick; Mettlen Marcel; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie Paule; Courtoy Pierre J
Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.
Experimental cell research 2002;281(1):86-100.
2002: Viaene Eric; Chanteux Hugues; Servais Hélène; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Comparative stability studies of antipseudomonal beta-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units).
Antimicrobial agents and chemotherapy 2002;46(8):2327-32.
2002: Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.
Antimicrobial agents and chemotherapy 2002;46(7):2095-103.
2001: Mingeot-Leclercq M P; Gallet X; Flore C; Van Bambeke F; Peuvot J; Brasseur R
Experimental and conformational analyses of interactions between butenafine and lipids.
Antimicrobial agents and chemotherapy 2001;45(12):3347-54.
2001: Tyteca D; Van Der Smissen P; Van Bambeke F; Leys K; Tulkens P M; Courtoy P J; Mingeot-Leclercq M P
Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts.
European journal of cell biology 2001;80(7):466-78.
2000: El Mouedden M; Laurent G; Mingeot-Leclercq M P; Tulkens P M
Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(1):229-39.
2000: El Mouedden M; Laurent G; Mingeot-Leclercq M P; Taper H S; Cumps J; Tulkens P M
Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides.
Antimicrobial agents and chemotherapy 2000;44(3):665-75.
2000: Van Bambeke F; Kerkhofs A; Schanck A; Remacle C; Sonveaux E; Tulkens P M; Mingeot-Leclercq M P
Biophysical studies and intracellular destabilization of pH-sensitive liposomes.
Lipids 2000;35(2):213-23.
1999: Mingeot-Leclercq M P; Tulkens P M
Aminoglycosides: nephrotoxicity.
Antimicrobial agents and chemotherapy 1999;43(5):1003-12.
1999: Montenez J P; Van Bambeke F; Piret J; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
Toxicology and applied pharmacology 1999;156(2):129-40.
1999: Mingeot-Leclercq M P; Glupczynski Y; Tulkens P M
Aminoglycosides: activity and resistance.
Antimicrobial agents and chemotherapy 1999;43(4):727-37.
1996: Montenez J P; Van Bambeke F; Piret J; Schanck A; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
European journal of pharmacology 1996;314(1-2):215-27.
1996: Van Bambeke F; Montenez J P; Piret J; Tulkens P M; Courtoy P J; Mingeot-Leclercq M P
Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity.
European journal of pharmacology 1996;314(1-2):203-14.
1996: van Bambeke F; Mingeot-Leclercq M P; Brasseur R; Tulkens P M; Schanck A
Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents.
Chemistry and physics of lipids 1996;79(2):123-35.
1995: Kotretsou S; Mingeot-Leclercq M P; Constantinou-Kokotou V; Brasseur R; Georgiadis M P; Tulkens P M
Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
Journal of medicinal chemistry 1995;38(23):4710-9.
1995: Van Bambeke F; Tulkens P M; Brasseur R; Mingeot-Leclercq M P
Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
European journal of pharmacology 1995;289(2):321-33.
1995: Mingeot-Leclercq M P; Brasseur R; Schanck A
Molecular parameters involved in aminoglycoside nephrotoxicity.
Journal of toxicology and environmental health 1995;44(3):263-300.
1993: Van Bambeke F; Mingeot-Leclercq M P; Schanck A; Brasseur R; Tulkens P M
Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
European journal of pharmacology 1993;247(2):155-68.
1992: Mingeot-Leclercq M P; Tulkens P M; Brasseur R
Accessibility of aminoglycosides, isolated and in interaction with phosphatidylinositol, to water. A conformational analysis using the concept of molecular hydrophobicity potential.
Biochemical pharmacology 1992;44(10):1967-75.
1992: Schanck A; Mingeot-Leclercq M P; Tulkens P M; Carrier D; Smith I C; Jarrell H C
Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study.
Chemistry and physics of lipids 1992;62(2):153-63.
1991: Van Schepdael A; Busson R; Vanderhaeghe H J; Claes P J; Verbist L; Mingeot-Leclercq M P; Brasseur R; Tulkens P M
New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation.
Journal of medicinal chemistry 1991;34(4):1483-92.
1991: Mingeot-Leclercq M P; Van Schepdael A; Brasseur R; Busson R; Vanderhaeghe H J; Claes P J; Tulkens P M
New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.
Journal of medicinal chemistry 1991;34(4):1476-82.
1991: Van Schepdael A; Delcourt J; Mulier M; Busson R; Verbist L; Vanderhaeghe H J; Mingeot-Leclercq M P; Tulkens P M; Claes P J
New derivatives of kanamycin B obtained by modifications and substitutions in position 6". 1. Synthesis and microbiological evaluation.
Journal of medicinal chemistry 1991;34(4):1468-75.
1990: Mingeot-Leclercq M P; Piret J; Tulkens P M; Brasseur R
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition induced by aminoglycoside antibiotics--II. Conformational analysis.
Biochemical pharmacology 1990;40(3):499-506.
1990: Mingeot-Leclercq M P; Piret J; Brasseur R; Tulkens P M
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics--I. Biochemical analysis.
Biochemical pharmacology 1990;40(3):489-97.
1989: Mingeot-Leclercq M P; Schanck A; Ronveaux-Dupal M F; Deleers M; Brasseur R; Ruysschaert J M; Laurent G; Tulkens P M
Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether) hexestrol with negatively-charged phospholipid layers.
Biochemical pharmacology 1989;38(5):729-41.
1988: Mingeot-Leclercq M P; Laurent G; Tulkens P M
Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases.
Biochemical pharmacology 1988;37(4):591-9.

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