Luisa Minghetti

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Cacci Emanuele; Ajmone-Cat Maria Antonietta; Anelli Tonino; Biagioni Stefano; Minghetti Luisa
In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia.
Berry A; Greco A; Giorgio M; Pelicci P G; de Kloet R; Alleva E; Minghetti L; Cirulli F
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Piscopo Paola; Bernardo Antonietta; Calamandrei Gemma; Venerosi Aldina; Valanzano Angela; Bianchi Daniela; Confaloni Annamaria; Minghetti Luisa
Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia.

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2008: Cacci Emanuele; Ajmone-Cat Maria Antonietta; Anelli Tonino; Biagioni Stefano; Minghetti Luisa
In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia.
Glia 2008;56(4):412-25.
2008: Berry A; Greco A; Giorgio M; Pelicci P G; de Kloet R; Alleva E; Minghetti L; Cirulli F
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Experimental gerontology 2008;43(3):200-8.
2008: Piscopo Paola; Bernardo Antonietta; Calamandrei Gemma; Venerosi Aldina; Valanzano Angela; Bianchi Daniela; Confaloni Annamaria; Minghetti Luisa
Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia.
Experimental neurology 2008;209(1):192-8.
2008: Ajmone-Cat Maria Antonietta; Cacci Emanuele; Minghetti Luisa
Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain.
Current pharmaceutical design 2008;14(14):1435-42.
2008: Bernardo Antonietta; Minghetti Luisa
Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.
PPAR research 2008;2008():864140.
2008: Malchiodi-Albedi Fiorella; Matteucci Andrea; Bernardo Antonietta; Minghetti Luisa
PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches.
PPAR research 2008;2008():295784.
2007: Carnevale D; De Simone R; Minghetti L
Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems.
CNS & neurological disorders drug targets 2007;6(6):388-97.
2007: Greco Anita; Minghetti Luisa; Puopolo Maria; Pietrobon Beatrice; Franzoi Malida; Chiandetti Lino; Suppiej Agnese
Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery.
Clinical biochemistry 2007;40(18):1420-2.
2007: De Simone R; Ambrosini E; Carnevale D; Ajmone-Cat M A; Minghetti L
NGF promotes microglial migration through the activation of its high affinity receptor: modulation by TGF-beta.
Journal of neuroimmunology 2007;190(1-2):53-60.
2007: Potenza R L; Tebano M T; Martire A; Domenici M R; Pepponi R; Armida M; Pèzzola A; Minghetti L; Popoli P
Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease.
Purinergic signalling 2007;3(4):333-8.
2007: Minghetti Luisa; Greco Anita; Potenza Rosa Luisa; Pezzola Antonella; Blum David; Bantubungi Kadiombo; Popoli Patrizia
Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration.
Journal of neuropathology and experimental neurology 2007;66(5):363-71.
2007: Berry Alessandra; Capone Francesca; Giorgio Marco; Pelicci Pier Giuseppe; de Kloet E R; Alleva Enrico; Minghetti Luisa; Cirulli Francesca
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Experimental gerontology 2007;42(1-2):37-45.
2007: Minghetti Luisa; Pocchiari Maurizio
Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases.
International review of neurobiology 2007;82():265-75.
2007: Minghetti Luisa
Role of COX-2 in inflammatory and degenerative brain diseases.
Sub-cellular biochemistry 2007;42():127-41.
2006: Ajmone-Cat Maria Antonietta; Iosif Robert E; Ekdahl Christine T; Kokaia Zaal; Minghetti Luisa; Lindvall Olle
Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons.
Neurobiology of disease 2006;23(1):23-35.
2006: Bernardo Antonietta; Gasparini Laura; Ongini Ennio; Minghetti Luisa
Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.
Neurobiology of disease 2006;22(1):25-32.
2006: Combrinck M; Williams J; De Berardinis M A; Warden D; Puopolo M; Smith A D; Minghetti L
Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2006;77(1):85-8.
2006: Minghetti Luisa; Greco Anita; Puopolo Maria; Combrinck Marc; Warden Donald; Smith A David
Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer's disease.
Journal of neuroinflammation 2006;3():4.
2006: Bernardo Antonietta; Minghetti Luisa
PPAR-gamma agonists as regulators of microglial activation and brain inflammation.
Current pharmaceutical design 2006;12(1):93-109.
2005: Pepicelli Olimpia; Fedele Ernesto; Berardi Maria; Raiteri Maurizio; Levi Giulio; Greco Anita; Ajmone-Cat Maria Antonietta; Minghetti Luisa
Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.
Journal of neurochemistry 2005;93(6):1561-7.
2005: Minghetti Luisa
Role of inflammation in neurodegenerative diseases.
Current opinion in neurology 2005;18(3):315-21.
2005: Minghetti Luisa; Ajmone-Cat Maria Antonietta; De Berardinis Maria Anna; De Simone Roberta
Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation.
Brain research. Brain research reviews 2005;48(2):251-6.
2005: Bernardo Antonietta; Ajmone-Cat Maria Antonietta; Gasparini Laura; Ongini Ennio; Minghetti Luisa
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen.
Journal of neurochemistry 2005;92(4):895-903.
2005: Bantubungi Kadiombo; Jacquard Carine; Greco Anita; Pintor Annita; Chtarto Abdelwahed; Tai Khalid; Galas Marie-Christine; Tenenbaum Liliane; Déglon Nicole; Popoli Patrizia; Minghetti Luisa; Brouillet Emmanuel; Brotchi Jacques; Levivier Marc; Schiffmann Serge N; Blum David
Minocycline in phenotypic models of Huntington's disease.
Neurobiology of disease 2005;18(1):206-17.
2004: Greco Anita; Minghetti Luisa
Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseases.
Current neurovascular research 2004;1(4):341-54.
2004: Minghetti Luisa
Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases.
Journal of neuropathology and experimental neurology 2004;63(9):901-10.
2004: Greco Anita; Minghetti Luisa; Puopolo Maria; Cannoni Stefania; Romano Silvia; Pozzilli Carlo; Levi Giulio
Cerebrospinal fluid isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis.
Journal of the neurological sciences 2004;224(1-2):23-7.
2004: Ricceri Laura; Minghetti Luisa; Moles Anna; Popoli Patrizia; Confaloni Annamaria; De Simone Roberta; Piscopo Paola; Scattoni Maria Luisa; di Luca Monica; Calamandrei Gemma
Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats.
Experimental neurology 2004;189(1):162-72.
2004: Popoli Patrizia; Pintor Annita; Tebano Maria Teresa; Frank Claudio; Pepponi Rita; Nazzicone Valeria; Grieco Rosa; Pèzzola Antonella; Reggio Rosaria; Minghetti Luisa; De Berardinis Maria Anna; Martire Alberto; Potenza Rosa Luisa; Domenici Maria Rosaria; Massotti Marino
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
Journal of neurochemistry 2004;89(6):1479-89.
2004: Branchi Igor; Bichler Zoë; Minghetti Luisa; Delabar Jean Maurice; Malchiodi-Albedi Fiorella; Gonzalez Marie-Claude; Chettouh Zoubidda; Nicolini Alessia; Chabert Caroline; Smith Desmond J; Rubin Edward M; Migliore-Samour Danièle; Alleva Enrico
Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.
Journal of neuropathology and experimental neurology 2004;63(5):429-40.
2004: Minghetti Luisa; Visentin Sergio; Patrizio Mario; Franchini Laura; Ajmone-Cat Maria Antonietta; Levi Giulio
Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions.
Neurochemical research 2004;29(5):965-78.
2004: De Simone Roberta; Ajmone-Cat Maria Antonietta; Minghetti Luisa
Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction.
Molecular neurobiology 2004;29(2):197-212.
2004: Calamandrei Gemma; Venerosi Aldina P; Valanzano Angela; de Berardinis Maria Anna; Greco Anita; Puopolo Maria; Minghetti Luisa
Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia.
Pediatric research 2004;55(1):85-92.
2004: Popoli Patrizia; Minghetti Luisa; Tebano Maria Teresa; Pintor Annita; Domenici Maria Rosaria; Massotti Marino
Adenosine A2A receptor antagonism and neuroprotection: mechanisms, lights, and shadows.
Critical reviews in neurobiology 2004;16(1-2):99-106.
2003: Ajmone-Cat M A; Nicolini A; Minghetti L
Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis.
Journal of neurochemistry 2003;87(5):1193-203.
2003: Bernardo Antonietta; Ajmone-Cat Maria Antonietta; Levi Giulio; Minghetti Luisa
15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms.
Journal of neurochemistry 2003;87(3):742-51.
2003: Bernardo Antonietta; Greco Anita; Levi Giulio; Minghetti Luisa
Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress.
Journal of neuropathology and experimental neurology 2003;62(5):509-19.
2003: Greco Anita; Ajmone-Cat Maria Antonietta; Nicolini Alessia; Sciulli Maria Gina; Minghetti Luisa
Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase.
Journal of neuroscience research 2003;71(6):844-52.
2003: De Simone Roberta; Ajmone-Cat Maria Antonietta; Tirassa Paola; Minghetti Luisa
Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells.
Journal of neuropathology and experimental neurology 2003;62(2):208-16.
2003: Ajmone-Cat M A; De Simone R; Nicolini A; Minghetti L
Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells.
Journal of neurochemistry 2003;84(2):413-6.
2002: Guastadisegni Cecilia; Nicolini Alessia; Balduzzi Maria; Ajmone-Cat Maria Antonietta; Minghetti Luisa
Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells.
Cytokine 2002;19(4):175-80.
2002: Pepicelli O; Fedele E; Bonanno G; Raiteri M; Ajmone-Cat M A; Greco A; Levi G; Minghetti L
In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms.
Journal of neurochemistry 2002;81(5):1028-34.
2002: Domenici M R; Paradisi S; Sacchetti B; Gaudi S; Balduzzi M; Bernardo A; Ajmone-Cat M A; Minghetti L; Malchiodi-Albedi F
The presence of astrocytes enhances beta amyloid-induced neurotoxicity in hippocampal cell cultures.
Journal of physiology, Paris 2002;96(3-4):313-6.
2002: De Simone Roberta; Ajmone-Cat Maria Antonietta; Nicolini Alessia; Minghetti Luisa
Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures.
Journal of neuropathology and experimental neurology 2002;61(3):237-44.
2002: Minghetti L; Cardone F; Greco A; Puopolo M; Levi G; Green A J E; Knight R; Pocchiari M
Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease.
Neurology 2002;58(1):127-9.
2001: Ajmone-Cat M A; Nicolini A; Minghetti L
Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia.
Journal of neuroscience research 2001;66(4):715-22.
2001: Nicolini A; Ajmone-Cat M A; Bernardo A; Levi G; Minghetti L
Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-kappaB activation and oxidative stress in microglial cultures by independent mechanisms.
Journal of neurochemistry 2001;79(3):713-6.
2001: Malchiodi-Albedi F; Domenici M R; Paradisi S; Bernardo A; Ajmone-Cat M A; Minghetti L
Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons.
Glia 2001;34(1):68-72.
2001: Minghetti L; Bernardo A; Greco A
[Isoprostanes and oxidative stress in brain damage in newborns]
Annali dell'Istituto superiore di sanità 2001;37(4):537-43.
2000: Minghetti L; Greco A; Cardone F; Puopolo M; Ladogana A; Almonti S; Cunningham C; Perry V H; Pocchiari M; Levi G
Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies.
Journal of neuropathology and experimental neurology 2000;59(10):866-71.
2000: Greco A; Minghetti L; Levi G
Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases.
Neurochemical research 2000;25(9-10):1357-64.
2000: Bernardo A; Levi G; Minghetti L
Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions.
The European journal of neuroscience 2000;12(7):2215-23.
2000: Walsh D T; Perry V H; Minghetti L
Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease.
Glia 2000;29(4):392-6.
1999: Greco A; Minghetti L; Sette G; Fieschi C; Levi G
Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis.
Neurology 1999;53(8):1876-9.
1999: Minghetti L; Walsh D T; Levi G; Perry V H
In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines.
Journal of neuropathology and experimental neurology 1999;58(11):1184-91.
1999: Polazzi E; Levi G; Minghetti L
Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures.
Journal of neuropathology and experimental neurology 1999;58(8):825-31.
1999: Minghetti L; Nicolini A; Polazzi E; Greco A; Perretti M; Parente L; Levi G
Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.
British journal of pharmacology 1999;126(6):1307-14.
1999: Aloisi F; Penna G; Polazzi E; Minghetti L; Adorini L
CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1384-91.
1999: Guastadisegni C; Minghetti L; Nicolini A; Polazzi E; Balduzzi M; Levi G
Different effects of reactive nitrogen intermediates on prostaglandin E2 synthesis in cultured rat microglia and RAW 264.7 cells.
Advances in experimental medicine and biology 1999;469():169-74.
1999: Minghetti L; Polazzi E; Nicolini A; Greco A; Levi G
Possible role of microglial prostanoids and free radicals in neuroprotection and neurodegeneration.
Advances in experimental medicine and biology 1999;468():109-19.
1999: Minghetti L; Hughes P; Perry V H
Restricted cyclooxygenase-2 expression in the central nervous system following acute and delayed-type hypersensitivity responses to bacillus Calmette-Guérin.
Neuroscience 1999;92(4):1405-15.
1998: Levi G; Minghetti L; Aloisi F
Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions.
Biochimie 1998;80(11):899-904.
1998: Minghetti L; Polazzi E; Nicolini A; Levi G
Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-beta1 and interleukin 10 in activated microglial cultures.
Journal of neuroimmunology 1998;82(1):31-9.
1998: Minghetti L; Levi G
Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide.
Progress in neurobiology 1998;54(1):99-125.
1997: Palma C; Minghetti L; Astolfi M; Ambrosini E; Silberstein F C; Manzini S; Levi G; Aloisi F
Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production.
Glia 1997;21(2):183-93.
1997: Guastadisegni C; Minghetti L; Nicolini A; Polazzi E; Ade P; Balduzzi M; Levi G
Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells.
FEBS letters 1997;413(2):314-8.
1997: Slepko N; Minghetti L; Polazzi E; Nicolini A; Levi G
Reorientation of prostanoid production accompanies "activation" of adult microglial cells in culture.
Journal of neuroscience research 1997;49(3):292-300.
1997: Minghetti L; Polazzi E; Nicolini A; Créminon C; Levi G
Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs.
The European journal of neuroscience 1997;9(5):934-40.
1997: Minghetti L; Nicolini A; Polazzi E; Créminon C; Maclouf J; Levi G
Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors.
Glia 1997;19(2):152-60.
1997: Minghetti L; Nicolini A; Polazzi E; Créminon C; Maclouf J; Levi G
Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels.
Advances in experimental medicine and biology 1997;433():181-4.
1996: Minghetti L; Polazzi E; Nicolini A; Créminon C; Levi G
Interferon-gamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression.
Journal of neurochemistry 1996;66(5):1963-70.
1995: Minghetti L; Levi G
Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures.
Journal of neurochemistry 1995;65(6):2690-8.

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Luisa Minghetti

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