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Joseph Beavo

Research Profile

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TOP 3
Stephen M Kraynik; Robert S Miyaoka; Joseph A Beavo
PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue.
Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Justin Percival; Nicholas P Whitehead; Candace M Adamo; Marvin Adams; Joseph A Beavo; Stanley C Froehner
Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy.

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All Publications

2013: Stephen M Kraynik; Robert S Miyaoka; Joseph A Beavo
PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue.
Molecular pharmacology 2013;83(6):1155-65.
2013: Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1533-42.
2012: Justin Percival; Nicholas P Whitehead; Candace M Adamo; Marvin Adams; Joseph A Beavo; Stanley C Froehner
Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy.
The Journal of pathology 2012;228(1):77-87.
2012: Masami Shimizu-Albergine; Li-Chun Lisa Tsai; Enrico Patrucco; Joseph A Beavo
cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.
Molecular pharmacology 2012;81(4):556-66.
2011: Li-Chun Lisa Tsai; Joseph A Beavo
The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis.
Current opinion in pharmacology 2011;11(6):670-5.
2011: Prapapan Temkitthawon; Jarupa Viyoch; Joseph A Beavo; Thomas R Hinds; Wittaya Pongamornkul; Pattara Sawasdee; Khanit Suwanborirux; Kornkanok Ingkaninan
Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors.
Journal of ethnopharmacology 2011;137(3):1437-41.
2011: Li-Chun Lisa Tsai; Masami Shimizu-Albergine; Joseph A Beavo
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.
Molecular pharmacology 2011;79(4):639-48.
2011: Angie L Hertz; Joseph A Beavo
Cyclic nucleotides and phosphodiesterases in monocytic differentiation.
Handbook of experimental pharmacology 2011;(204):365-90.
2011: Justin Percival; Candace M Adamo; Joseph A Beavo; Stanley C Froehner
Evaluation of the therapeutic utility of phosphodiesterase 5A inhibition in the mdx mouse model of duchenne muscular dystrophy.
Handbook of experimental pharmacology 2011;(204):323-44.
2011: James Surapisitchat; Joseph A Beavo
Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases.
Handbook of experimental pharmacology 2011;(204):193-210.
2010: Candace M Adamo; Dao-Fu Dai; Justin Percival; Elina Minami; Monte S Willis; Enrico Patrucco; Stanley Froehner; Joseph A Beavo
Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):19079-83.
2010: Enrico Patrucco; Masami Shimizu Albergine; Luis F Santana; Joseph A Beavo
Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes.
Journal of molecular and cellular cardiology 2010;49(2):330-3.
2010: Robert Lukowski; Sergei D Rybalkin; Florian Loga; Veronika Leiss; Joseph A Beavo; Franz Hofmann
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5646-51.
2009: Angie L Hertz; Andrew T Bender; Kimberly C Smith; Mark Gilchrist; Paul S Amieux; Alan Aderem; Joseph A Beavo
Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21978-83.
2009: Clint L Miller; Masayoshi Oikawa; Yujun Cai; Andrew P Wojtovich; David J Nagel; Xiangbin Xu; Haodong Xu; Vince Florio; Sergei D Rybalkin; Joseph A Beavo; Yiu-Fai Chen; Jian-Dong Li; Burns C Blaxall; Jun-ichi Abe; Chen Yan
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
Circulation research 2009;105(10):956-64.
2008: Sergio E Martinez; Clemens C Heikaus; Rachel E Klevit; Joseph A Beavo
The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change.
The Journal of biological chemistry 2008;283(38):25913-9.
2008: Clemens C Heikaus; Joseph R Stout; Monica R Sekharan; Catherine M. Eakin; Ponni Rajagopal; Peter S Brzovic; Joseph A Beavo; Rachel E Klevit
Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change.
The Journal of biological chemistry 2008;283(33):22749-59.
2008: Heiko Poppe; Sergei D Rybalkin; Holger Rehmann; Thomas R Hinds; Xiao-Bo Tang; Anne E Christensen; Frank Schwede; Hans-Gottfried Genieser; Johannes L Bos; Stein O Doskeland; Joseph A Beavo; Elke Butt
Cyclic nucleotide analogs as probes of signaling pathways.
Nature methods 2008;5(4):277-8.
2007: David A Kass; Hunter C Champion; Joseph A Beavo
Phosphodiesterase type 5: expanding roles in cardiovascular regulation.
Circulation research 2007;101(11):1084-95.
2007: James Surapisitchat; Kye-Im Jeon; Chen Yan; Joseph A Beavo
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.
Circulation research 2007;101(8):811-8.
2007: Sunil Laxman; Joseph A Beavo
Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.
Molecular interventions 2007;7(4):203-15.
2007: Bardia Askari; Jenny E Kanter; Ashley M Sherrid; Deidre L Golej; Andrew T Bender; Joey Liu; Willa A Hsueh; Joseph A Beavo; Rosalind A Coleman; Karin E Bornfeldt
Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.
Diabetes 2007;56(4):1143-52.
2007: Marc A Gavin; Jeffrey P Rasmussen; Jason D Fontenot; Valeria Vasta; Vincent C Manganiello; Joseph A Beavo; Alexander Y Rudensky
Foxp3-dependent programme of regulatory T-cell differentiation.
Nature 2007;445(7129):771-5.
2006: Valeria Vasta; Masami Shimizu-Albergine; Joseph A Beavo
Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19925-30.
2006: Sunil Laxman; Aaron Riechers; Martin Sadilek; Frank Schwede; Joseph A Beavo
Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19194-9.
2006: Rocío Díaz-Benjumea; Sunil Laxman; Thomas R Hinds; Joseph A Beavo; Ana Rascón
Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.
The Biochemical journal 2006;399(2):305-14.
2006: Andrew T Bender; Joseph A Beavo
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use.
Pharmacological reviews 2006;58(3):488-520.
2006: Andrew T Bender; Joseph A Beavo
PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):460-5.
2006: Stefan Kunz; Joseph A Beavo; Maximiliano A D'Angelo; Mirtha M Flawia; Sharron H Francis; Andrea Johner; Sunil Laxman; Michael Oberholzer; Ana Rascon; Yasmin Shakur; Laurent Wentzinger; Roya Zoraghi; Thomas Seebeck
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.
Molecular and biochemical parasitology 2006;145(1):133-5.
2005: Valeria Vasta; William K Sonnenburg; Chen Yan; Scott Haydn Soderling; Masami Shimizu-Albergine; Joseph A Beavo
Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.
Biology of reproduction 2005;73(4):598-609.
2005: Sergio E Martinez; Sandra Bruder; Anita Schultz; Ning Zheng; Joachim E Schultz; Joseph A Beavo; Jürgen U Linder
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3082-7.
2005: Sandra Bruder; Jürgen U Linder; Sergio E Martinez; Ning Zheng; Joseph A Beavo; Joachim E Schultz
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3088-92.
2005: Sunil Laxman; Ana Rascón; Joseph A Beavo
Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain.
The Journal of biological chemistry 2005;280(5):3771-9.
2005: Andrew T Bender; Cari L Ostenson; Edith H Wang; Joseph A Beavo
Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):497-502.
2004: Daming Huang; Thomas R Hinds; Sergio E Martinez; Catalin E Doneanu; Joseph A Beavo
Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase.
The Journal of biological chemistry 2004;279(46):48143-51.
2004: Andrew T Bender; Joseph A Beavo
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages.
Neurochemistry international 2004;45(6):853-7.
2004: Angela L Asirvatham; Sarah G Galligan; Robynn V Schillace; Michael P Davey; Valeria Vasta; Joseph A Beavo; Daniel W Carr
A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4806-14.
2004: Albert Y Wu; Xiao-Bo Tang; Sergio E Martinez; Kaori Ikeda; Joseph A Beavo
Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A.
The Journal of biological chemistry 2004;279(36):37928-38.
2004: Andrew T Bender; Cari L Ostenson; Daniela Giordano; Joseph A Beavo
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression.
Cellular signalling 2004;16(3):365-74.
2003: Wilma C G van Staveren; Harry W M Steinbusch; Marjanne Markerink-van Ittersum; David R Repaske; Michael F Goy; Jun Kotera; Kenji Omori; Joseph A Beavo; Jan de Vente
mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain.
The Journal of comparative neurology 2003;467(4):566-80.
2003: Daniela Giordano; Dario M Magaletti; Edward A Clark; Joseph A Beavo
Cyclic nucleotides promote monocyte differentiation toward a DC-SIGN+ (CD209) intermediate cell and impair differentiation into dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6421-30.
2003: Sergei D Rybalkin; Chen Yan; Karin E Bornfeldt; Joseph A Beavo
Cyclic GMP phosphodiesterases and regulation of smooth muscle function.
Circulation research 2003;93(4):280-91.
2003: Masami Shimizu-Albergine; Sergei D Rybalkin; Irina G Rybalkina; Robert Feil; Wiebke Wolfsgruber; Franz Hofmann; Joseph A Beavo
Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(16):6452-9.
2003: Khakim G Muradov; Kimberly K Boyd; Sergio E Martinez; Joseph A Beavo; Nikolai O Artemyev
The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization.
The Journal of biological chemistry 2003;278(12):10594-601.
2003: Sergei D Rybalkin; Irina G Rybalkina; Masami Shimizu-Albergine; Xiao-Bo Tang; Joseph A Beavo
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain.
The EMBO journal 2003;22(3):469-78.
2002: Sergio E Martinez; Albert Y Wu; Natalie A Glavas; Xiao-Bo Tang; Stewart Turley; Wim G J Hol; Joseph A Beavo
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13260-5.
2002: Sergio E Martinez; Joseph A Beavo; Wim G J Hol
GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides.
Molecular interventions 2002;2(5):317-23.
2002: Wilma C G van Staveren; J Glick; Marjanne Markerink-van Ittersum; M Shimizu; Joseph A Beavo; Harry W M Steinbusch; Jan de Vente
Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain.
Journal of neurocytology 2002;31(8-9):729-41.
2002: Joseph A Beavo; Laurence L Brunton
Cyclic nucleotide research -- still expanding after half a century.
Nature reviews. Molecular cell biology 2002;3(9):710-8.
2002: Ana Rascón; Scott Haydn Soderling; Jonathan B Schaefer; Joseph A Beavo
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4714-9.
2002: Sergei D Rybalkin; Irina G Rybalkina; Joseph A Beavo; Karin E Bornfeldt
Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation.
Circulation research 2002;90(2):151-7.
2002: Sergei D Rybalkin; Irina G Rybalkina; Robert Feil; Franz Hofmann; Joseph A Beavo
Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.
The Journal of biological chemistry 2002;277(5):3310-7.
2001: Dongsoo Kim; Sergei D Rybalkin; Xinchun Pi; Y Wang; Changxi Zhang; T Munzel; Joseph A Beavo; Bradford C Berk; Chen Yan
Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.
Circulation 2001;104(19):2338-43.
2001: Chen Yan; AZ Zhao; William K Sonnenburg; Joseph A Beavo
Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.
Biology of reproduction 2001;64(6):1746-54.
2001: Natalie A Glavas; Cari L Ostenson; Jonathan B Schaefer; Valeria Vasta; Joseph A Beavo
T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6319-24.
2001: TA Cook; Farideh Ghomashchi; Michael H Gelb; SK Florio; Joseph A Beavo
The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments.
The Journal of biological chemistry 2001;276(7):5248-55.
2001: Masami Shimizu-Albergine; D L Ippolito; Joseph A Beavo
Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(4):1238-46.
2000: TA Cook; Farideh Ghomashchi; Michael H Gelb; SK Florio; Joseph A Beavo
Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits.
Biochemistry 2000;39(44):13516-23.
2000: JM Hetman; Nicola Robas; R Baxendale; Mark Fidock; SC Phillips; Scott Haydn Soderling; Joseph A Beavo
Cloning and characterization of two splice variants of human phosphodiesterase 11A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12891-5.
2000: Y Sun; Linheng Li; F Lau; Joseph A Beavo; Edward A Clark
Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1755-61.
2000: AZ Zhao; M M Shinohara; D Huang; M Shimizu; H Eldar-Finkelman; Edwin G Krebs; Joseph A Beavo; Karin E Bornfeldt
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes.
The Journal of biological chemistry 2000;275(15):11348-54.
2000: Scott Haydn Soderling; Joseph A Beavo
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
Current opinion in cell biology 2000;12(2):174-9.
2000: L Fawcett; R Baxendale; P Stacey; C McGrouther; I Harrow; Scott Haydn Soderling; JM Hetman; Joseph A Beavo; SC Phillips
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3702-7.
2000: JM Hetman; Scott Haydn Soderling; Natalie A Glavas; Joseph A Beavo
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):472-6.
2000: TA Cook; Joseph A Beavo
Purification and assay of bovine type 6 photoreceptor phosphodiesterase and its subunits.
Methods in enzymology 2000;315():597-616.
1999: Hongmei Mou; H J Grazio; TA Cook; Joseph A Beavo; Rick H Cote
cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits.
The Journal of biological chemistry 1999;274(26):18813-20.
1999: Scott Haydn Soderling; SJ Bayuga; Joseph A Beavo
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7071-6.
1999: Linheng Li; C Yee; Joseph A Beavo
CD3- and CD28-dependent induction of PDE7 required for T cell activation.
Science (New York, N.Y.) 1999;283(5403):848-51.
1999: D M Juilfs; Scott Haydn Soderling; F Burns; Joseph A Beavo
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).
Reviews of physiology, biochemistry and pharmacology 1999;135():67-104.
1998: J Wei; AZ Zhao; Guy C-K Chan; LP Baker; Soren Impey; Joseph A Beavo; Daniel R Storm
Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.
Neuron 1998;21(3):495-504.
1998: AZ Zhao; Karin E Bornfeldt; Joseph A Beavo
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
The Journal of clinical investigation 1998;102(5):869-73.
1998: Kate Loughney; T R Hill; Vincent A Florio; Lothar Uher; GJ Rosman; Sharon L Wolda; B A Jones; M L Howard; Linda M McAllister-Lucas; William K Sonnenburg; S H Francis; J D Corbin; Joseph A Beavo; K Ferguson
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
Gene 1998;216(1):139-47.
1998: Scott Haydn Soderling; SJ Bayuga; Joseph A Beavo
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8991-6.
1998: K A Hanson; F Burns; S D Rybalkin; J W Miller; Joseph A Beavo; WR Clarke
Developmental changes in lung cGMP phosphodiesterase-5 activity, protein, and message.
American journal of respiratory and critical care medicine 1998;158(1):279-88.
1998: Scott Haydn Soderling; SJ Bayuga; Joseph A Beavo
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
The Journal of biological chemistry 1998;273(25):15553-8.
1998: N Li; SK Florio; M J Pettenati; P N Rao; Joseph A Beavo; Wolfgang Baehr
Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene.
Genomics 1998;49(1):76-82.
1998: William K Sonnenburg; Sergei D Rybalkin; Karin E Bornfeldt; K S Kwak; Irina G Rybalkina; Joseph A Beavo
Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases.
Methods (San Diego, Calif.) 1998;14(1):3-19.
1997: Sergei D Rybalkin; Karin E Bornfeldt; William K Sonnenburg; Irina G Rybalkina; K S Kwak; K Hanson; Edwin G Krebs; Joseph A Beavo
Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.
The Journal of clinical investigation 1997;100(10):2611-21.
1997: J Yu; Sharon L Wolda; A L Frazier; Vincent A Florio; T J Martins; Peter B Snyder; E A Harris; K N McCaw; C A Farrell; B Steiner; Kelley Bentley; Joseph A Beavo; K Ferguson; R Gelinas
Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1.
Cellular signalling 1997;9(7):519-29.
1997: GJ Rosman; T J Martins; William K Sonnenburg; Joseph A Beavo; K Ferguson; Kate Loughney
Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase.
Gene 1997;191(1):89-95.
1997: D M Juilfs; H J Fülle; AZ Zhao; Miles D Houslay; David L Garbers; Joseph A Beavo
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3388-95.
1997: AZ Zhao; H Zhao; Jeanette C Teague; Wilfred Y Fujimoto; Joseph A Beavo
Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3223-8.
1997: AZ Zhao; Chen Yan; William K Sonnenburg; Joseph A Beavo
Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions.
Advances in second messenger and phosphoprotein research 1997;31():237-51.
1996: T J Bloom; Joseph A Beavo
Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14188-92.
1996: Sergei D Rybalkin; Joseph A Beavo
Multiplicity within cyclic nucleotide phosphodiesterases.
Biochemical Society transactions 1996;24(4):1005-9.
1996: C Yan; AZ Zhao; Kelley Bentley; Joseph A Beavo
The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.
The Journal of biological chemistry 1996;271(41):25699-706.
1996: S K Florio; R K Prusti; Joseph A Beavo
Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit.
The Journal of biological chemistry 1996;271(39):24036-47.
1996: Kate Loughney; T J Martins; E A Harris; K Sadhu; J B Hicks; William K Sonnenburg; Joseph A Beavo; K Ferguson
Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.
The Journal of biological chemistry 1996;271(2):796-806.
1996: F Burns; AZ Zhao; Joseph A Beavo
Cyclic nucleotide phosphodiesterases: gene complexity, regulation by phosphorylation, and physiological implications.
Advances in pharmacology (San Diego, Calif.) 1996;36():29-48.
1995: William K Sonnenburg; D Seger; K S Kwak; Jing Huang; H Charbonneau; Joseph A Beavo
Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases.
The Journal of biological chemistry 1995;270(52):30989-1000.
1995: Linda M McAllister-Lucas; T L Haik; J L Colbran; William K Sonnenburg; D Seger; IV Turko; Joseph A Beavo; Sharron H Francis; Jackie D Corbin
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase.
The Journal of biological chemistry 1995;270(51):30671-9.
1995: C Yan; AZ Zhao; Kelley Bentley; Kate Loughney; K Ferguson; Joseph A Beavo
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9677-81.
1995: Joseph A Beavo
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.
Physiological reviews 1995;75(4):725-48.
1995: E C Villacres; Z Wu; W Hua; M D Nielsen; J J Watters; C Yan; Joseph A Beavo; Daniel R Storm
Developmentally expressed Ca(2+)-sensitive adenylyl cyclase activity is disrupted in the brains of type I adenylyl cyclase mutant mice.
The Journal of biological chemistry 1995;270(24):14352-7.
1995: E Butt; J Beltman; D E Becker; G S Jensen; Sergei D Rybalkin; B Jastorff; Joseph A Beavo
Characterization of cyclic nucleotide phosphodiesterases with cyclic AMP analogs: topology of the catalytic sites and comparison with other cyclic AMP-binding proteins.
Molecular pharmacology 1995;47(2):340-7.
1995: J Beltman; D E Becker; E Butt; G S Jensen; Sergei D Rybalkin; B Jastorff; Joseph A Beavo
Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains.
Molecular pharmacology 1995;47(2):330-9.
1994: Joseph A Beavo; M Conti; R J Heaslip
Multiple cyclic nucleotide phosphodiesterases.
Molecular pharmacology 1994;46(3):399-405.
1994: Vincent A Florio; William K Sonnenburg; R Johnson; K S Kwak; G S Jensen; KA Walsh; Joseph A Beavo
Phosphorylation of the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase at serine 120 reduces its affinity for calmodulin.
Biochemistry 1994;33(30):8948-54.
1994: C Yan; Kelley Bentley; William K Sonnenburg; Joseph A Beavo
Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(3 Pt 1):973-84.
1994: William K Sonnenburg; Joseph A Beavo
Cyclic GMP and regulation of cyclic nucleotide hydrolysis.
Advances in pharmacology (San Diego, Calif.) 1994;26():87-114.
1993: J Beltman; William K Sonnenburg; Joseph A Beavo
The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases.
Molecular and cellular biochemistry 1993;127-128():239-53.
1993: T Michaeli; T J Bloom; T Martins; Kate Loughney; K Ferguson; M Riggs; L Rodgers; Joseph A Beavo; Michael Wigler
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(17):12925-32.
1993: S C Chan; D Reifsnyder; Joseph A Beavo; Jon M Hanifin
Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis.
The Journal of allergy and clinical immunology 1993;91(6):1179-88.
1993: Susan E Hamilton; R K Prusti; Kelley Bentley; Joseph A Beavo; James B Hurley
Affinities of bovine photoreceptor cGMP phosphodiesterases for rod and cone inhibitory subunits.
FEBS letters 1993;318(2):157-61.
1993: William K Sonnenburg; D Seger; Joseph A Beavo
Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms.
The Journal of biological chemistry 1993;268(1):645-52.
1992: Kelley Bentley; A Kadlecek; C H Sherbert; D Seger; William K Sonnenburg; H Charbonneau; J P Novack; Joseph A Beavo
Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain.
The Journal of biological chemistry 1992;267(26):18676-82.
1992: E Butt; C Nolte; S Schulz; J Beltman; Joseph A Beavo; B Jastorff; Ulrich Walter
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP.
Biochemical pharmacology 1992;43(12):2591-600.
1992: Kelley Bentley; Joseph A Beavo
Regulation and function of cyclic nucleotides.
Current opinion in cell biology 1992;4(2):233-40.
1992: S D Stroop; Joseph A Beavo
Sequence homology and structure--function studies of the bovine cyclic-GMP-stimulated and retinal phosphodiesterases.
Advances in second messenger and phosphoprotein research 1992;25():55-71.
1991: S D Stroop; Joseph A Beavo
Structure and function studies of the cGMP-stimulated phosphodiesterase.
The Journal of biological chemistry 1991;266(35):23802-9.
1991: William K Sonnenburg; P J Mullaney; Joseph A Beavo
Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants.
The Journal of biological chemistry 1991;266(26):17655-61.
1991: J P Novack; H Charbonneau; Kelley Bentley; KA Walsh; Joseph A Beavo
Sequence comparison of the 63-, 61-, and 59-kDa calmodulin-dependent cyclic nucleotide phosphodiesterases.
Biochemistry 1991;30(32):7940-7.
1991: H Charbonneau; S Kumar; J P Novack; D K Blumenthal; P R Griffin; Jeffrey Shabanowitz; Donald F Hunt; Joseph A Beavo; KA Walsh
Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain.
Biochemistry 1991;30(32):7931-40.
1991: R T MacFarland; B D Zelus; Joseph A Beavo
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.
The Journal of biological chemistry 1991;266(1):136-42.
1990: H L Trong; N Beier; William K Sonnenburg; S D Stroop; KA Walsh; Joseph A Beavo; H Charbonneau
Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart.
Biochemistry 1990;29(44):10280-8.
1990: Eileen L Watson; Jean C Singh; C McPhee; Joseph A Beavo; Kerry L Jacobson
Regulation of cAMP metabolism in mouse parotid gland by cGMP and calcium.
Molecular pharmacology 1990;38(4):547-53.
1990: Joseph A Beavo; D H Reifsnyder
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.
Trends in pharmacological sciences 1990;11(4):150-5.
1990: H Charbonneau; R K Prusti; H LeTrong; William K Sonnenburg; P J Mullaney; KA Walsh; Joseph A Beavo
Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):288-92.
1989: Peter G Gillespie; Joseph A Beavo
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948.
Molecular pharmacology 1989;36(5):773-81.
1989: S D Stroop; H Charbonneau; Joseph A Beavo
Direct photolabeling of the cGMP-stimulated cyclic nucleotide phosphodiesterase.
The Journal of biological chemistry 1989;264(23):13718-25.
1989: Peter G Gillespie; R K Prusti; E D Apel; Joseph A Beavo
A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunit.
The Journal of biological chemistry 1989;264(21):12187-93.
1989: Peter G Gillespie; Joseph A Beavo
cGMP is tightly bound to bovine retinal rod phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4311-5.
1989: J P Novack; H Charbonneau; D K Blumenthal; KA Walsh; Joseph A Beavo
The domain structure of the calmodulin-dependent phosphodiesterase isozymes.
Advances in experimental medicine and biology 1989;255():387-95.
1988: D K Blumenthal; H Charbonneau; A M Edelman; Thomas R Hinds; G B Rosenberg; Daniel R Storm; F F Vincenzi; Joseph A Beavo; Edwin G Krebs
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.
Biochemical and biophysical research communications 1988;156(2):860-5.
1988: C H Macphee; D H Reifsnyder; T A Moore; K M Lerea; Joseph A Beavo
Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.
The Journal of biological chemistry 1988;263(21):10353-8.
1988: Peter G Gillespie; Joseph A Beavo
Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography.
The Journal of biological chemistry 1988;263(17):8133-41.
1988: Joseph A Beavo
Multiple isozymes of cyclic nucleotide phosphodiesterase.
Advances in second messenger and phosphoprotein research 1988;22():1-38.
1988: S A Harrison; N Beier; T J Martins; Joseph A Beavo
Isolation and comparison of bovine heart cGMP-inhibited and cGMP-stimulated phosphodiesterases.
Methods in enzymology 1988;159():685-702.
1988: R S Hansen; H Charbonneau; Joseph A Beavo
Purification of calmodulin-stimulated cyclic nucleotide phosphodiesterase by monoclonal antibody affinity chromatography.
Methods in enzymology 1988;159():543-57.
1986: H Charbonneau; N Beier; KA Walsh; Joseph A Beavo
Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9308-12.
1986: R S Hansen; Joseph A Beavo
Differential recognition of calmodulin-enzyme complexes by a conformation-specific anti-calmodulin monoclonal antibody.
The Journal of biological chemistry 1986;261(31):14636-45.
1986: C H Macphee; S A Harrison; Joseph A Beavo
Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6660-3.
1986: S A Harrison; D H Reifsnyder; B Gallis; G G Cadd; Joseph A Beavo
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs.
Molecular pharmacology 1986;29(5):506-14.
1986: S A Harrison; M L Chang; Joseph A Beavo
Differential inhibition of cardiac cyclic nucleotide phosphodiesterase isozymes by cardiotonic drugs.
Circulation 1986;73(3 Pt 2):III109-16.
1986: C H Macphee; D H Reifsnyder; T A Moore; Joseph A Beavo
Intact cell and cell-free phosphorylation and concomitant activation of a low Km, cAMP phosphodiesterase found in human platelets.
Journal of cyclic nucleotide and protein phosphorylation research 1986;11(7):487-96.
1984: R L Hurwitz; R S Hansen; S A Harrison; T J Martins; M C Mumby; Joseph A Beavo
Immunologic approaches to the study of cyclic nucleotide phosphodiesterases.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():89-106.
1982: M C Mumby; T J Martins; M L Chang; Joseph A Beavo
Identification of cGMP-stimulated cyclic nucleotide phosphodiesterase in lung tissue with monoclonal antibodies.
The Journal of biological chemistry 1982;257(22):13283-90.
1982: Joseph A Beavo; R S Hansen; S A Harrison; R L Hurwitz; T J Martins; M C Mumby
Identification and properties of cyclic nucleotide phosphodiesterases.
Molecular and cellular endocrinology 1982;28(3):387-410.
1982: R S Hansen; Joseph A Beavo
Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(9):2788-92.
1982: T J Martins; M C Mumby; Joseph A Beavo
Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.
The Journal of biological chemistry 1982;257(4):1973-9.