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Giorgio Minotti

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Emanuela Salvatorelli; Jack W Singer; Odalys Gonzalez Paz; Massimo Chello; Elvio Covino; Pierantonio Menna; Giorgio Minotti
The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.
Emanuela Salvatorelli; Consiglia Carella; Antonella Colasante; Michele De Tursi; Stefano Iacobelli; Renato Massari; Pierantonio Menna; Giorgio Minotti
Pharmacokinetics of pegylated liposomal doxorubicin administered by intraoperative hyperthermic intraperitoneal chemotherapy to patients with advanced ovarian cancer and peritoneal carcinomatosis.
Emanuela Salvatorelli; Victoria Sung; Sekhar Surapaneni; Sharon L Aukerman; Massimo Chello; Elvio Covino; Odalys Gonzalez Paz; Pierantonio Menna; Giorgio Minotti
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. II. Amrubicin shows metabolic advantages over doxorubicin and epirubicin.

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2013: Emanuela Salvatorelli; Jack W Singer; Odalys Gonzalez Paz; Massimo Chello; Elvio Covino; Pierantonio Menna; Giorgio Minotti
The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.
The Journal of pharmacology and experimental therapeutics 2013;344(2):467-78.
2012: Emanuela Salvatorelli; Consiglia Carella; Antonella Colasante; Michele De Tursi; Stefano Iacobelli; Renato Massari; Pierantonio Menna; Giorgio Minotti
Pharmacokinetics of pegylated liposomal doxorubicin administered by intraoperative hyperthermic intraperitoneal chemotherapy to patients with advanced ovarian cancer and peritoneal carcinomatosis.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(12):2365-73.
2012: Emanuela Salvatorelli; Victoria Sung; Sekhar Surapaneni; Sharon L Aukerman; Massimo Chello; Elvio Covino; Odalys Gonzalez Paz; Pierantonio Menna; Giorgio Minotti
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. II. Amrubicin shows metabolic advantages over doxorubicin and epirubicin.
The Journal of pharmacology and experimental therapeutics 2012;341(2):474-83.
2012: Emanuela Salvatorelli; Victoria Sung; Sekhar Surapaneni; Sharon L Aukerman; Massimo Chello; Elvio Covino; Pierantonio Menna; Giorgio Minotti
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. I. Amrubicin accumulates to a lower level than doxorubicin or epirubicin.
The Journal of pharmacology and experimental therapeutics 2012;341(2):464-73.
2012: Pierantonio Menna; Massimo Chello; Elvio Covino; Emanuela Salvatorelli; Odalys Gonzalez Paz; Giorgio Minotti
Anthracycline cardiotoxicity.
Expert opinion on drug safety 2012;11 Suppl 1():S21-36.
2011: Fabio Cacciapaglia; Pierantonio Menna; Giorgio Minotti; Luca Navarini; Emanuela Salvatorelli; Antonella Afeltra
Cardiovascular safety of anti-TNF-alpha therapies: facts and unsettled issues.
Autoimmunity reviews 2011;10(10):631-5.
2010: Stefania Recalcati; Giorgio Minotti; Gaetano Cairo
Iron regulatory proteins: from molecular mechanisms to drug development.
Antioxidants & redox signaling 2010;13(10):1593-616.
2008: Pierantonio Menna; Luca Gianni; Emanuela Salvatorelli; Giorgio Minotti
Anthracycline cardiotoxicity.
Topics in current chemistry 2008;283():21-44.
2007: Pierantonio Menna; Emanuela Salvatorelli; Giorgio Minotti
Doxorubicin degradation in cardiomyocytes.
The Journal of pharmacology and experimental therapeutics 2007;322(1):408-19.
2007: Emanuela Salvatorelli; Pierantonio Menna; Luca Gianni; Giorgio Minotti
Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-taxane chemotherapies.
The Journal of pharmacology and experimental therapeutics 2007;320(2):790-800.
2007: Pierantonio Menna; Stefania Recalcati; Gaetano Cairo; Giorgio Minotti
An introduction to the metabolic determinants of anthracycline cardiotoxicity.
Cardiovascular toxicology 2007;7(2):80-5.
2007: Luca Gianni; Emanuela Salvatorelli; Giorgio Minotti
Anthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanes.
Cardiovascular toxicology 2007;7(2):67-71.
2007: Pierantonio Menna; Giorgio Minotti; Emanuela Salvatorelli
In vitro modeling of the structure-activity determinants of anthracycline cardiotoxicity.
Cell biology and toxicology 2007;23(1):49-62.
2006: Emanuela Salvatorelli; Pierantonio Menna; Sabrina Cascegna; Giovanni Liberi; Antonio M Calafiore; Luca Gianni; Giorgio Minotti
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies.
The Journal of pharmacology and experimental therapeutics 2006;318(1):424-33.
2006: Emanuela Salvatorelli; Simone Guarnieri; Pierantonio Menna; Giovanni Liberi; Antonio M Calafiore; Maria A Mariggiò; Alvaro Mordente; Luca Gianni; Giorgio Minotti
Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.
The Journal of biological chemistry 2006;281(16):10990-1001.
2004: Giorgio Minotti; Pierantonio Menna; Emanuela Salvatorelli; Gaetano Cairo; Luca Gianni
Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity.
Pharmacological reviews 2004;56(2):185-229.
2004: Gianfranca Corna; Paolo Santambrogio; Giorgio Minotti; Gaetano Cairo
Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin.
The Journal of biological chemistry 2004;279(14):13738-45.
2004: Cristiana Sessa; Antonella Perotti; Emanuela Salvatorelli; Giorgio Minotti; Lucia Viganò; Anna Lladò; Giuseppe Capri; Alberta Locatelli; S Colombini; Fedro Alessandro Peccatori; Maurizio Voi; Silvia Marsoni; Luca Gianni
Phase IB and pharmacological study of the novel taxane BMS-184476 in combination with doxorubicin.
European journal of cancer (Oxford, England : 1990) 2004;40(4):563-70.
2004: Antonella Cartoni; Pierantonio Menna; Emanuela Salvatorelli; Daniela Braghiroli; Rossella Giampietro; Fabio Animati; Andrea Urbani; Piero Del Boccio; Giorgio Minotti
Oxidative degradation of cardiotoxic anticancer anthracyclines to phthalic acids. Novel function or ferrylmyoglobin.
The Journal of biological chemistry 2004;279(7):5088-99.
2004: Giorgio Minotti; Stefania Recalcati; Pierantonio Menna; Emanuela Salvatorelli; Gianfranca Corna; Gaetano Cairo
Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms.
Methods in enzymology 2004;378():340-61.
2003: Alvaro Mordente; Giorgio Minotti; Giuseppe Ettore Martorana; Andrea Silvestrini; Bruno Giardina; Elisabetta Meucci
Anthracycline secondary alcohol metabolite formation in human or rabbit heart: biochemical aspects and pharmacologic implications.
Biochemical pharmacology 2003;66(6):989-98.
2003: Giuseppe Sacco; Rossella Giampietro; Emanuela Salvatorelli; Pierantonio Menna; Nicoletta Bertani; Gallia Graiani; Fabio Animati; Cristina Goso; Carlo Alberto Maggi; Stefano Manzini; Giorgio Minotti
Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity.
British journal of pharmacology 2003;139(3):641-51.
2003: Luca Gianni; Giacomo Grasselli; Sara Cresta; Alberta Locatelli; Lucia Viganò; Giorgio Minotti
Anthracyclines.
Cancer chemotherapy and biological response modifiers 2003;21():29-40.
2003: Antonella Perotti; Sara Cresta; Giacomo Grasselli; Giuseppe Capri; Giorgio Minotti; Luca Gianni
Cardiotoxic effects of anthracycline-taxane combinations.
Expert opinion on drug safety 2003;2(1):59-71.
2002: Pierantonio Menna; Emanuela Salvatorelli; Rossella Giampietro; Giovanni Liberi; Giovanni Teodori; Antonio M Calafiore; Giorgio Minotti
Doxorubicin-dependent reduction of ferrylmyoglobin and inhibition of lipid peroxidation: implications for cardiotoxicity of anticancer anthracyclines.
Chemical research in toxicology 2002;15(9):1179-89.
2002: Gaetano Cairo; Stefania Recalcati; Antonello Pietrangelo; Giorgio Minotti
The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.
Free radical biology & medicine 2002;32(12):1237-43.
2002: Gaetano Cairo; Raffaella Ronchi; Stefania Recalcati; Alessandro Campanella; Giorgio Minotti
Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.
Biochemistry 2002;41(23):7435-42.
2002: Luca Gianni; Giacomo Grasselli; Sara Cresta; Alberta Locatelli; Lucia Viganò; Giorgio Minotti
Anthracyclines.
Cancer chemotherapy and biological response modifiers 2002;20():59-69.
2001: Giorgio Minotti; Raffaella Ronchi; Emanuela Salvatorelli; Pierantonio Menna; Gaetano Cairo
Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy.
Cancer research 2001;61(23):8422-8.
2001: Giorgio Minotti; Massimo Parlani; Emanuela Salvatorelli; Pierantonio Menna; A Cipollone; Fabio Animati; Carlo Alberto Maggi; Stefano Manzini
Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue.
British journal of pharmacology 2001;134(6):1271-8.
2001: Alvaro Mordente; Elisabetta Meucci; Giuseppe Ettore Martorana; Bruno Giardina; Giorgio Minotti
Human heart cytosolic reductases and anthracycline cardiotoxicity.
IUBMB life 2001;52(1-2):83-8.
2001: Giorgio Minotti; A Saponiero; S Licata; Pierantonio Menna; Antonio M Calafiore; G Teodori; Luca Gianni
Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(6):1511-5.
2000: Giorgio Minotti; S Licata; A Saponiero; Pierantonio Menna; Antonio M Calafiore; G Di Giammarco; Giovanni Liberi; Fabio Animati; A Cipollone; Stefano Manzini; Carlo Alberto Maggi
Anthracycline metabolism and toxicity in human myocardium: comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite.
Chemical research in toxicology 2000;13(12):1336-41.
2000: S Licata; A Saponiero; Alvaro Mordente; Giorgio Minotti
Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction.
Chemical research in toxicology 2000;13(5):414-20.
1999: Giorgio Minotti; Gaetano Cairo; E Monti
Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(2):199-212.
1998: Gaetano Cairo; Lorenza Tacchini; Stefania Recalcati; B Azzimonti; Giorgio Minotti; Aldo Bernelli-Zazzera
Effect of reactive oxygen species on iron regulatory protein activity.
Annals of the New York Academy of Sciences 1998;851():179-86.
1998: Giorgio Minotti; Stefania Recalcati; Alvaro Mordente; Giovanni Liberi; Antonio M Calafiore; Cesare Mancuso; P Preziosi; Gaetano Cairo
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(7):541-52.
1998: Alvaro Mordente; Giuseppe Ettore Martorana; Giorgio Minotti; Bruno Giardina
Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone).
Chemical research in toxicology 1998;11(1):54-63.
1997: Cesare Mancuso; Ifigenia Kostoglou-Athanassiou; ML Forsling; Ashley B Grossman; P Preziosi; P Navarra; Giorgio Minotti
Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function.
Brain research. Molecular brain research 1997;50(1-2):267-76.
1996: Gaetano Cairo; E Castrusini; Giorgio Minotti; Aldo Bernelli-Zazzera
Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory protein activity: a protective stratagem against oxidative injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(11):1326-35.
1996: Giorgio Minotti; Cesare Mancuso; A Frustaci; Alvaro Mordente; S A Santini; A M Calafiore; G Liberi; Nicola Gentiloni
Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin. Pharmacologic and molecular reappraisal of anthracycline cardiotoxicity.
The Journal of clinical investigation 1996;98(3):650-61.
1995: Giorgio Minotti; A F Cavaliere; Alvaro Mordente; M Rossi; R Schiavello; R Zamparelli; G Possati
Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. Novel linkage between anthracycline metabolism and iron-induced cardiotoxicity.
The Journal of clinical investigation 1995;95(4):1595-605.
1994: Alvaro Mordente; S A Santini; A G Miggiano; Giuseppe Ettore Martorana; T Petiti; Giorgio Minotti; Bruno Giardina
The interaction of short chain coenzyme Q analogs with different redox states of myoglobin.
The Journal of biological chemistry 1994;269(44):27394-400.