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Filippo Minutolo

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Tiziano Tuccinardi; Simone Bertini; Carlotta Granchi; Marco Macchia; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Claudiu T Supuran
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Carlotta Granchi; Filippo Minutolo
Anticancer agents that counteract tumor glycolysis.
Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Marco Mottinelli; Elisa Nardini; Sarabindu Roy; Tiziano Tuccinardi; Laura Betti; Fabio Campinoti; Gino Giannaccini; Filippo Minutolo
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.

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All Publications

2013: Tiziano Tuccinardi; Simone Bertini; Carlotta Granchi; Marco Macchia; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Claudiu T Supuran
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Bioorganic & medicinal chemistry 2013;21(6):1511-5.
2012: Carlotta Granchi; Filippo Minutolo
Anticancer agents that counteract tumor glycolysis.
ChemMedChem 2012;7(8):1318-50.
2011: Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Marco Mottinelli; Elisa Nardini; Sarabindu Roy; Tiziano Tuccinardi; Laura Betti; Fabio Campinoti; Gino Giannaccini; Filippo Minutolo
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.
Bioorganic & medicinal chemistry letters 2011;21(24):7331-6.
2011: Valeria Di Bussolo; Filippo Minutolo
Curaxins: a new family of non-genotoxic multitargeted anticancer agents.
ChemMedChem 2011;6(12):2133-6.
2011: Simone Bertini; Andrea Bortolato; Elisa Ghilardi; Carlotta Granchi; Clementina Manera; Jonathan Mason; Filippo Minutolo; Stefano Moro; Giuseppe Saccomanni; Valentina Asso; Marco Macchia
Carbazole-containing arylcarboxamides as BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(22):6657-61.
2011: Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Laura Betti; Alessio De Simone; Gino Giannaccini; Elisa Giovannetti; Godefridus J Peters; Sarabindu Roy; Irene Salvetti; Rocco Sciarrillo; Tiziano Tuccinardi; Filippo Minutolo
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.
European journal of medicinal chemistry 2011;46(11):5398-407.
2011: Mehdi Rajabi; Simone Bertini; Marco Macchia; Filippo Minutolo; Riccardo Ghidoni
Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines.
DNA and cell biology 2011;30(8):617-21.
2011: Simone Bertini; Andrea De Cupertinis; Carlotta Granchi; Barbara Bargagli; Tiziano Tuccinardi; Adriano Martinelli; Marco Macchia; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Filippo Minutolo
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.
European journal of medicinal chemistry 2011;46(6):2453-62.
2011: Filippo Minutolo; Marco Macchia; Benita S Katzenellenbogen; John A Katzenellenbogen
Estrogen receptor β ligands: recent advances and biomedical applications.
Medicinal research reviews 2011;31(3):364-442.
2011: Carlotta Granchi; Sarabindu Roy; Chiara Giacomelli; Marco Macchia; Tiziano Tuccinardi; Adriano Martinelli; Mario Lanza; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Nicola Funel; Leticia G León; Elisa Giovannetti; Godefridus J Peters; Rahul Palchaudhuri; Emilia C Calvaresi; Paul J Hergenrother; Filippo Minutolo
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Journal of medicinal chemistry 2011;54(6):1599-612.
2010: Simone Bertini; Elisa Ghilardi; Valentina Asso; Carlotta Granchi; Filippo Minutolo; Mauro Pineschi; Valeria Di Bussolo; Andrea Bortolato; Stefano Moro; Alessandro Saba; Marco Macchia
BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides.
Bioorganic & medicinal chemistry 2010;18(22):7991-6.
2010: Simone Bertini; Vincenzo Calderone; Isabella Carboni; Roberta Maffei; Alma Martelli; Adriano Martinelli; Filippo Minutolo; Mehdi Rajabi; Lara Testai; Tiziano Tuccinardi; Riccardo Ghidoni; Marco Macchia
Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.
Bioorganic & medicinal chemistry 2010;18(18):6715-24.
2010: C Granchi; S Bertini; M Macchia; Filippo Minutolo
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials.
Current medicinal chemistry 2010;17(7):672-97.
2009: Carlotta Granchi; Tiziana Funaioli; Janine T Erler; Amato J Giaccia; Marco Macchia; Filippo Minutolo
Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.
ChemMedChem 2009;4(10):1590-4.
2009: Ilaria Massarelli; Marco Macchia; Filippo Minutolo; G Prota; Anna Maria Bianucci
QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design.
Bioorganic & medicinal chemistry 2009;17(10):3543-56.
2009: Filippo Minutolo; Simone Bertini; Carlotta Granchi; Teresa Marchitiello; Giovanni Prota; Simona Rapposelli; Tiziano Tuccinardi; Adriano Martinelli; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.
Journal of medicinal chemistry 2009;52(3):858-67.
2008: Maria Cristina Breschi; Vincenzo Calderone; Maria Digiacomo; Mariaelisa Manganaro; Alma Martelli; Filippo Minutolo; Simona Rapposelli; Lara Testai; Federica Tonelli; Aldo Balsamo
Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.
Journal of medicinal chemistry 2008;51(21):6945-54.
2008: Valentina Asso; Elisa Ghilardi; Simone Bertini; Maria Digiacomo; Carlotta Granchi; Filippo Minutolo; Simona Rapposelli; Andrea Bortolato; Stefano Moro; Marco Macchia
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors.
ChemMedChem 2008;3(10):1530-4.
2008: Filippo Minutolo; R Bellini; Simone Bertini; Isabella Carboni; Annalina Lapucci; Letizia Pistolesi; Giovanni Prota; Simona Rapposelli; Francesca Solati; Tiziano Tuccinardi; Adriano Martinelli; Fabio Stossi; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen; Marco Macchia
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.
Journal of medicinal chemistry 2008;51(5):1344-51.
2008: Vincenzo Calderone; Maria Digiacomo; Alma Martelli; Filippo Minutolo; Simona Rapposelli; Lara Testai; Aldo Balsamo
Evaluation of the NO-releasing properties of NO-donor linkers.
The Journal of pharmacy and pharmacology 2008;60(2):189-95.
2007: Filippo Minutolo; Maria Grazia Cascio; I Carboni; Tiziana Bisogno; Giovanni Prota; Simone Bertini; Maria Digiacomo; Maurizio Bifulco; Vincenzo Di Marzo; Marco Macchia
Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.
Bioorganic & medicinal chemistry letters 2007;17(17):4878-81.
2006: Maria Cristina Breschi; Vincenzo Calderone; Alma Martelli; Filippo Minutolo; Simona Rapposelli; Lara Testai; Federica Tonelli; Aldo Balsamo
New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
Journal of medicinal chemistry 2006;49(26):7600-2.
2006: Tiziano Tuccinardi; Simone Bertini; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Giorgio Placanica; Giovanni Prota; Simona Rapposelli; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.
Journal of medicinal chemistry 2006;49(16):5001-12.
2006: Maria Cristina Breschi; Vincenzo Calderone; Maria Digiacomo; Marco Macchia; Alma Martelli; Enrica Martinotti; Filippo Minutolo; Simona Rapposelli; Armando Rossello; Lara Testai; Aldo Balsamo
New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.
Journal of medicinal chemistry 2006;49(8):2628-39.
2006: Chiara Laezza; Maria Notarnicola; Maria Gabriella Caruso; Caterina Messa; Marco Macchia; Simone Bertini; Filippo Minutolo; Giuseppe Portella; Laura Fiorentino; Stefania Stingo; Maurizio Bifulco
N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):412-8.
2006: Filippo Minutolo; Simone Bertini; Laura Betti; Romano Danesi; Gianbattista Gervasi; Gino Giannaccini; Adriano Martinelli; Anna Maria Papini; Elisa Peroni; Giorgio Placanica; Simona Rapposelli; Tiziano Tuccinardi; Marco Macchia
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.
ChemMedChem 2006;1(2):218-24.
2005: Filippo Minutolo; Giusy Sala; Annalisa Bagnacani; Simone Bertini; Isabella Carboni; Giorgio Placanica; Giovanni Prota; Simona Rapposelli; Nicoletta Sacchi; Marco Macchia; Riccardo Ghidoni
Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.
Journal of medicinal chemistry 2005;48(22):6783-6.
2005: Filippo Minutolo; Valentina Asso; Simone Bertini; Laura Betti; Massimiliano Ciriaco; Romano Danesi; Gianbattista Gervasi; Elisa Ghilardi; Elisa Giovanetti; Gino Giannaccini; Giorgio Placanica; Giovanni Prota; Simona Rapposelli; Marco Macchia
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2005;1(3):239-44.
2004: Maria Cristina Breschi; Vincenzo Calderone; Maria Digiacomo; Alma Martelli; Enrica Martinotti; Filippo Minutolo; Simona Rapposelli; Aldo Balsamo
NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs.
Journal of medicinal chemistry 2004;47(23):5597-600.
2004: Filippo Minutolo; Michela Antonello; Silvia Barontini; Simone Bertini; Laura Betti; Romano Danesi; Gianbattista Gervasi; Gino Giannaccini; Chiara Papi; Giorgio Placanica; Simona Rapposelli; Marco Macchia
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.
Farmaco (Società chimica italiana : 1989) 2004;59(11):887-92.
2004: Filippo Minutolo; Valentina Asso; Simone Bertini; Laura Betti; Gianbattista Gervasi; Elisa Ghilardi; Gino Giannaccini; Giorgio Placanica; Giovanni Prota; Simona Rapposelli; Marco Macchia
Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase.
Farmaco (Società chimica italiana : 1989) 2004;59(11):857-61.
2004: Filippo Minutolo; Michela Antonello; Simone Bertini; Giorgio Placanica; Simona Rapposelli; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.
Farmaco (Società chimica italiana : 1989) 2004;59(8):601-7.
2004: Armando Rossello; Elisa Nuti; Elisabetta Orlandini; Paolo Carelli; Simona Rapposelli; Marco Macchia; Filippo Minutolo; Laura Carbonaro; Adriana Albini; Roberto Benelli; Giovanni Cercignani; Gillian Murphy; Aldo Balsamo
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).
Bioorganic & medicinal chemistry 2004;12(9):2441-50.
2004: Simona Rapposelli; Annalina Lapucci; Filippo Minutolo; Elisabetta Orlandini; Gabriella Ortore; Mario Pinza; Aldo Balsamo
Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.
Farmaco (Società chimica italiana : 1989) 2004;59(1):25-31.
2003: Filippo Minutolo; Simone Bertini; Laura Betti; Romano Danesi; Gianbattista Gervasi; Gino Giannaccini; Chiara Papi; Giorgio Placanica; Silvia Barontini; Simona Rapposelli; Marco Macchia
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.
Bioorganic & medicinal chemistry letters 2003;13(24):4405-8.
2003: Filippo Minutolo; Simone Bertini; Laura Betti; Valeria Di Bussolo; Gino Giannaccini; Giorgio Placanica; Simona Rapposelli; H Peter Spielmann; Marco Macchia
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity.
Farmaco (Società chimica italiana : 1989) 2003;58(12):1277-81.
2003: Filippo Minutolo; Michela Antonello; Simone Bertini; Gabriella Ortore; Giorgio Placanica; Simona Rapposelli; Shubin Sheng; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen; Marco Macchia
Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.
Journal of medicinal chemistry 2003;46(19):4032-42.
2003: Filippo Minutolo; Michela Antonello; Simone Bertini; Simona Rapposelli; Armando Rossello; Shubin Sheng; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta.
Bioorganic & medicinal chemistry 2003;11(7):1247-57.
2003: Marco Macchia; Simone Bertini; Stefano Fogli; Elisa Giovannetti; Filippo Minutolo; Simona Rapposelli; Romano Danesi
Ceramide analogues in apoptosis: a new strategy for anticancer drug development.
Farmaco (Società chimica italiana : 1989) 2003;58(3):205-11.
2003: Aldo Balsamo; Isabella Coletta; Angelo Guglielmotti; Carla Landolfi; Francesca Mancini; Adriano Martinelli; Claudio Milanese; Filippo Minutolo; Susanna Nencetti; Elisabetta Orlandini; Mario Pinza; Simona Rapposelli; Armando Rossello
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
European journal of medicinal chemistry 2003;38(2):157-68.
2003: Marco Macchia; Luigi Cervetto; Gian Carlo Demontis; Biancamaria Longoni; Filippo Minutolo; Elisabetta Orlandini; Gabriella Ortore; Chiara Papi; Alfredo Sbrana; Bruno Macchia
New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
Journal of medicinal chemistry 2003;46(1):161-8.
2003: Giusy Sala; Filippo Minutolo; Marco Macchia; Nicoletta Sacchi; Riccardo Ghidoni
Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells.
Drugs under experimental and clinical research 2003;29(5-6):263-9.
2003: Marco Macchia; Michela Antonello; Simone Bertini; Valeria Di Bussolo; Stefano Fogli; Elisa Giovannetti; Filippo Minutolo; Simona Rapposelli; Romano Danesi
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.
Farmaco (Società chimica italiana : 1989) 2003;58(1):85-9.
2002: Marco Macchia; Simone Bertini; Valeria Di Bussolo; Clementina Manera; Claudia Martini; Filippo Minutolo; Claudio Mori; Giuseppe Saccomanni; Daniela Tuscano; Pier Luigi Ferrarini
4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.
Farmaco (Società chimica italiana : 1989) 2002;57(10):783-6.
2002: Aldo Balsamo; Isabella Coletta; Angelo Guglielmotti; Carla Landolfi; Annalina Lapucci; Francesca Mancini; Claudio Milanese; Filippo Minutolo; Elisabetta Orlandini; Gabriella Ortore; Mario Pinza; Simona Rapposelli
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties.
European journal of medicinal chemistry 2002;37(7):585-94.
2001: Marco Macchia; teresina laragione; Simone Bertini; Valeria Di Bussolo; L Gattuso; Marco Gesi; Mahmoud Hamdan; Karl-Norbert Klotz; T Laragione; Antonio Lucacchini; Filippo Minutolo; Susanna Nencetti; Chiara Papi; Daniela Tuscano; Claudia Martini
7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.
Bioorganic & medicinal chemistry letters 2001;11(23):3023-6.
2001: Filippo Minutolo; Simone Bertini; Chiara Papi; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Salicylaldoxime moiety as a phenolic "A-Ring" substitute in estrogen receptor ligands.
Journal of medicinal chemistry 2001;44(24):4288-91.
2001: Marco Macchia; Silvia Barontini; Simone Bertini; Valeria Di Bussolo; Stefano Fogli; Elisa Giovannetti; enzo grossi; Filippo Minutolo; Romano Danesi
Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues.
Journal of medicinal chemistry 2001;44(23):3994-4000.
2001: Mark C Schulbach; Sebabrata Mahapatra; Marco Macchia; Silvia Barontini; Chiara Papi; Filippo Minutolo; Simone Bertini; Patrick J Brennan; Dean Crick
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2001;276(15):11624-30.
2001: Bruno Macchia; Luigi Cervetto; Gian Carlo Demontis; P Domiano; Biancamaria Longoni; Marco Macchia; Filippo Minutolo; Elisabetta Orlandini; Gabriella Ortore; Chiara Papi
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.
Bioorganic & medicinal chemistry letters 2001;11(2):223-6.
2000: Marco Macchia; Guido Antonelli; Simone Bertini; F Calvani; Valeria Di Bussolo; Filippo Minutolo; R Tesoro; I Tonetti; Ombretta Turriziani
Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir.
Farmaco (Società chimica italiana : 1989) 2000;55(4):322-7.
2000: Marco Macchia; Guido Antonelli; F Calvani; Valeria Di Bussolo; Filippo Minutolo; Elisabetta Orlandini; R Tesoro; Ombretta Turriziani
Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues.
Farmaco (Società chimica italiana : 1989) 2000;55(2):104-8.