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Françoise Miot

Research Profile

Anatomy

Chemicals & Drugs

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Thyroid Neoplasms

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Karin Fink; Emmanuelle Brochiero; Stéfany Chartier; Xavier De Deken; Lydie Martin; Françoise Miot; Esperance Mukawera; Nathalie Grandvaux
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response.
Houssam Raad; Bernard Corvilain; Zineb Eskalli; Françoise Miot; Xavier De Deken
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
Ielham Hadad; Agnès Mendes Da Costa; Françoise Miot; Robert Naeije; Panagiota A Sotiropoulou; Jean-Yves Springael; Alex Veithen; Xavier De Deken; Kathleen Mc Entee
Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes.

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All Publications

2013: Karin Fink; Emmanuelle Brochiero; Stéfany Chartier; Xavier De Deken; Lydie Martin; Françoise Miot; Esperance Mukawera; Nathalie Grandvaux
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response.
Cell research 2013;23(5):673-90.
2013: Houssam Raad; Bernard Corvilain; Zineb Eskalli; Françoise Miot; Xavier De Deken
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
Free radical biology & medicine 2013;56():216-25.
2013: Ielham Hadad; Agnès Mendes Da Costa; Françoise Miot; Robert Naeije; Panagiota A Sotiropoulou; Jean-Yves Springael; Alex Veithen; Xavier De Deken; Kathleen Mc Entee
Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes.
PloS one 2013;8(2):e56007.
2012: Candice Hoste; Françoise Miot; Jacques Emile Dumont; Xavier De Deken
The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.
Experimental cell research 2012;318(18):2353-64.
2010: Candice Hoste; Sabrina Rigutto; Guy Van Vliet; Françoise Miot; Xavier De Deken
Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism.
Human mutation 2010;31(4):E1304-19.
2009: Natacha Driessens; Soetkin Versteyhe; Chiraz Ghaddhab; Agnès Burniat; Xavier De Deken; Jacqueline Van Sande; Jacques-Emile Dumont; Françoise Miot; Bernard Corvilain
Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ.
Endocrine-related cancer 2009;16(3):845-56.
2009: Sabrina Rigutto; Candice Hoste; Helmut Grasberger; Milutin Milenkovic; David Communi; Jacques E Dumont; Bernard Corvilain; Françoise Miot; Xavier De Deken
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.
The Journal of biological chemistry 2009;284(11):6725-34.
2008: L Jin; A Burniat; Jacques E Dumont; Françoise Miot; Bernard Corvilain; Brigitte Franc
Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice.
British journal of cancer 2008;99(11):1874-83.
2008: Agnès Burniat; Ling Jin; Vincent Detours; Natacha Driessens; Jean-Christophe Goffard; Massimo Santoro; Jay Rothstein; Jacques E Dumont; Françoise Miot; Bernard Corvilain
Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers.
Endocrinology 2008;149(10):5107-17.
2007: Sabrina Rigutto; Candice Hoste; Jacques E Dumont; Bernard Corvilain; Françoise Miot; Xavier De Deken
Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3.
Experimental cell research 2007;313(18):3892-901.
2007: Y Song; N Driessens; M Costa; Xavier De Deken; Vincent Detours; Bernard Corvilain; Carine Maenhaut; Françoise Miot; Jacqueline Van Sande; Marie-Christine Many; Jacques E Dumont
Roles of hydrogen peroxide in thyroid physiology and disease.
The Journal of clinical endocrinology and metabolism 2007;92(10):3764-73.
2007: Helmut Grasberger; Xavier De Deken; Françoise Miot; Joachim Pohlenz; Samuel Refetoff
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1408-21.
2007: Milutin Milenkovic; Xavier De Deken; Ling Jin; Mario De Felice; Roberto Di Lauro; Jacques E Dumont; Bernard Corvilain; Françoise Miot
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.
The Journal of endocrinology 2007;192(3):615-26.
2005: Dantong Wang; Xavier De Deken; Milutin Milenkovic; Yue Song; Isabelle Pirson; Jacques E Dumont; Françoise Miot
Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
The Journal of biological chemistry 2005;280(4):3096-103.
2005: Nathalie Fortemaison; Françoise Miot; Jacques E Dumont; Sarah Dremier
Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(1):127-33.
2004: J Pachucki; D Wang; Daniel Christophe; Françoise Miot
Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.
Molecular and cellular endocrinology 2004;214(1-2):53-62.
2003: Anne-Catherine Gérard; Chantal Daumerie; C Mestdagh; S Gohy; Claire de Burbure; Sabine Costagliola; Françoise Miot; MC Nollevaux; Jean-François Denef; Jacques Rahier; B Franc; Jan J M de Vijlder; Ides M Colin; Marie-Christine Many
Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas.
The Journal of clinical endocrinology and metabolism 2003;88(10):4977-83.
2002: Anne-Catherine Gérard; Marie-Christine Many; Chantal Daumerie; Sabine Costagliola; Françoise Miot; J J M DeVijlder; Ides M Colin; Jean-François Denef
Structural changes in the angiofollicular units between active and hypofunctioning follicles align with differences in the epithelial expression of newly discovered proteins involved in iodine transport and organification.
The Journal of clinical endocrinology and metabolism 2002;87(3):1291-9.
2002: Xavier De Deken; Dantong Wang; Jacques E Dumont; Françoise Miot
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.
Experimental cell research 2002;273(2):187-96.
2000: Xavier De Deken; Dantong Wang; Marie-Christine Many; Sabine Costagliola; Frédérick Libert; Gilbert Vassart; Jacques E Dumont; Françoise Miot
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
The Journal of biological chemistry 2000;275(30):23227-33.
1999: J Golstein; T Kimura; Françoise Miot; Jacques E Dumont
Loss of several cell functions including okadaic acid-induced apoptosis after multiple passages in FRTL-5 cells.
Molecular and cellular endocrinology 1999;150(1-2):141-9.
1999: N Uyttersprot; S Costagliola; Jacques E Dumont; Françoise Miot
Requirement for cAMP-response element (CRE) binding protein/CRE modulator transcription factors in thyrotropin-induced proliferation of dog thyroid cells in primary culture.
European journal of biochemistry / FEBS 1999;259(1-2):370-8.
1998: Xavier De Deken; C Vilain; Jacqueline Van Sande; Jacques E Dumont; Françoise Miot
Decrease of telomere length in thyroid adenomas without telomerase activity.
The Journal of clinical endocrinology and metabolism 1998;83(12):4368-72.
1998: N Uyttersprot; S Costagliola; Françoise Miot
A new tool for efficient transfection of dog and human thyrocytes in primary culture.
Molecular and cellular endocrinology 1998;142(1-2):35-9.
1997: N Uyttersprot; N Pelgrims; Nancy Carrasco; C Gervy; Carine Maenhaut; Jacques E Dumont; Françoise Miot
Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid.
Molecular and cellular endocrinology 1997;131(2):195-203.
1997: N Uyttersprot; Françoise Miot
Dog CREM transcription factors: cloning, tissue distribution, and identification of new isoforms.
Biochemical and biophysical research communications 1997;237(1):74-8.
1997: Valérie Savonet; Carine Maenhaut; Françoise Miot; Isabelle Pirson
Pitfalls in the use of several "housekeeping" genes as standards for quantitation of mRNA: the example of thyroid cells.
Analytical biochemistry 1997;247(1):165-7.
1997: N Uyttersprot; A Allgeier; M Baptist; Daniel Christophe; F Coppee; Katia Coulonval; S Deleu; F Depoortere; Sarah Dremier; Françoise Lamy; C Ledent; Carine Maenhaut; Françoise Miot; V Panneels; Jasmine Parma; M Parmentier; Isabelle Pirson; Viviane Pohl; P Roger; Valérie Savonet; M Taton; M Tonacchera; Jacqueline Van Sande; Françoise Wilkin; Gilbert Vassart
The cAMP in thyroid: from the TSH receptor to mitogenesis and tumorigenesis.
Advances in second messenger and phosphoprotein research 1997;31():125-40.
1994: Françoise Miot; Françoise Wilkin; Sarah Dremier; N Uyttersprot; Françoise Lamy; Jacques E Dumont; Carine Maenhaut
Cloning of cDNA specifically involved in the thyroid cAMP mitogenic pathway.
Hormone research 1994;42(1-2):27-30.
1989: A Vandekerckhove; Françoise Miot; S Keppens; H De Wulf
Lack of V1 vasopressin receptors in rabbit hepatocytes.
The Biochemical journal 1989;259(2):609-11.
1988: Françoise Miot; S Keppens; C Erneux; J N Wells; H De Wulf
Involvement of a plasma membrane phosphodiesterase in the negative control of cyclic AMP levels by vasopressin in rat hepatocytes.
Biochemical pharmacology 1988;37(18):3447-53.
1985: C Erneux; Jacqueline Van Sande; Françoise Miot; P Cochaux; C Decoster; Jacques E Dumont
A mechanism in the control of intracellular cAMP level: the activation of a calmodulin-sensitive phosphodiesterase by a rise of intracellular free calcium.
Molecular and cellular endocrinology 1985;43(2-3):123-34.
1984: Françoise Miot; C Erneux; J N Wells; Jacques E Dumont
The effects of alkylated xanthines on cyclic AMP accumulation in dog thyroid slices exposed to carbamylcholine.
Molecular pharmacology 1984;25(2):261-6.
1984: Jacques E Dumont; Françoise Miot; C Erneux; D Couchie; P Cochaux; C Gervy-Decoster; Jacqueline Van Sande; J N Wells
Negative regulation of cyclic AMP levels by activation of cyclic nucleotide phosphodiesterases: the example of the dog thyroid.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():325-36.