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Katrina Miranda

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Nitrosation

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Publications

TOP 3
Wilmarie Flores-Santana; Debra J Salmon; Sonia Donzelli; Christopher H Switzer; Debashree Basudhar; Lisa A Ridnour; Robert Cheng; Sharon Anneve Glynn; Nazareno Paolocci; Jon M Fukuto; Katrina M Miranda; David A Wink
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
Debra J Salmon; Claudia L Torres de Holding; Lynta Thomas; Kyle V Peterson; Gens P Goodman; Joseph E Saavedra; Aloka Srinivasan; Keith M Davies; Larry K Keefer; Katrina M Miranda
HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH.
Daniela Andrei; Debra J Salmon; Sonia Donzelli; Azadeh Wahab; John R Klose; Michael L Citro; Joseph E Saavedra; David A Wink; Katrina M Miranda; Larry K Keefer
Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

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All Publications

2011: Wilmarie Flores-Santana; Debra J Salmon; Sonia Donzelli; Christopher H Switzer; Debashree Basudhar; Lisa A Ridnour; Robert Cheng; Sharon Anneve Glynn; Nazareno Paolocci; Jon M Fukuto; Katrina M Miranda; David A Wink
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
Antioxidants & redox signaling 2011;14(9):1659-74.
2011: Debra J Salmon; Claudia L Torres de Holding; Lynta Thomas; Kyle V Peterson; Gens P Goodman; Joseph E Saavedra; Aloka Srinivasan; Keith M Davies; Larry K Keefer; Katrina M Miranda
HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH.
Inorganic chemistry 2011;50(8):3262-70.
2010: Daniela Andrei; Debra J Salmon; Sonia Donzelli; Azadeh Wahab; John R Klose; Michael L Citro; Joseph E Saavedra; David A Wink; Katrina M Miranda; Larry K Keefer
Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.
Journal of the American Chemical Society 2010;132(46):16526-32.
2009: Matthew I Jackson; Tae H Han; Laura Serbulea; Andrew Dutton; Eleonora Ford; Katrina M Miranda; K N Houk; David A Wink; Jon M Fukuto
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Free radical biology & medicine 2009;47(8):1130-9.
2009: Thomas W Miller; Melisa M Cherney; Andrea J Lee; Nestor E Francoleon; Patrick J Farmer; S Bruce King; Adrian J Hobbs; Katrina M Miranda; Judith N Burstyn; Jon M Fukuto
The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.
The Journal of biological chemistry 2009;284(33):21788-96.
2009: Wilmarie Flores-Santana; Christopher H Switzer; Lisa A Ridnour; Debashree Basudhar; Daniele Mancardi; Sonia Donzelli; Douglas D Thomas; Katrina M Miranda; Jon M Fukuto; David A Wink
Comparing the chemical biology of NO and HNO.
Archives of pharmacal research 2009;32(8):1139-53.
2009: Christopher H Switzer; Wilmarie Flores-Santana; Daniele Mancardi; Sonia Donzelli; Debashree Basudhar; Lisa A Ridnour; Katrina M Miranda; Jon M Fukuto; Nazareno Paolocci; David A Wink
The emergence of nitroxyl (HNO) as a pharmacological agent.
Biochimica et biophysica acta 2009;1787(7):835-40.
2008: Sonia Donzelli; Michael G Espey; Wilmarie Flores-Santana; Christopher H Switzer; Grace C Yeh; Jinming Huang; Dennis J Stuehr; S Bruce King; Katrina M Miranda; David A Wink
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.
Free radical biology & medicine 2008;45(5):578-84.
2008: Anders Omsland; Katrina M Miranda; Richard L Friedman; Scott Boitano
Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses.
FEMS microbiology letters 2008;284(1):92-101.
2007: Nazareno Paolocci; Matthew I Jackson; Brenda E Lopez; Katrina M Miranda; Carlo G Tocchetti; David A Wink; Adrian J Hobbs; Jon M Fukuto
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.
Pharmacology & therapeutics 2007;113(2):442-58.
2006: Tatsuo Katori; Sonia Donzelli; Carlo G Tocchetti; Katrina M Miranda; Gianfrancesco Cormaci; Douglas D Thomas; Elizabeth A Ketner; Myung Jae Lee; Daniele Mancardi; David A Wink; David A Kass; Nazareno Paolocci
Peroxynitrite and myocardial contractility: in vivo versus in vitro effects.
Free radical biology & medicine 2006;41(10):1606-18.
2006: Sonia Donzelli; Christopher H Switzer; Douglas D Thomas; Lisa A Ridnour; Michael G Espey; Jeff S Isenberg; Carlo G Tocchetti; S Bruce King; Giuseppe Lazzarino; Katrina M Miranda; David D Roberts; Martin Feelisch; David A Wink
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.
Antioxidants & redox signaling 2006;8(7-8):1363-71.
2006: Andrew S Dutton; Christopher P Suhrada; Katrina M Miranda; David A Wink; Jon M Fukuto; Kendall N Houk
Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations.
Inorganic chemistry 2006;45(6):2448-56.
2006: Sonia Donzelli; Michael G Espey; Douglas D Thomas; Daniele Mancardi; Carlo G Tocchetti; Lisa A Ridnour; Nazareno Paolocci; S Bruce King; Katrina M Miranda; Giuseppe Lazzarino; Jon M Fukuto; David A Wink
Discriminating formation of HNO from other reactive nitrogen oxide species.
Free radical biology & medicine 2006;40(6):1056-66.
2005: Katrina M Miranda; Tatsuo Katori; Claudia L Torres de Holding; Lynta Thomas; Lisa A Ridnour; William J McLendon; Stephanie M Cologna; Andrew S Dutton; Hunter C Champion; Daniele Mancardi; Carlo G Tocchetti; Joseph E Saavedra; Larry K Keefer; Kendall N Houk; Jon M Fukuto; David A Kass; Nazareno Paolocci; David A Wink
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
Journal of medicinal chemistry 2005;48(26):8220-8.
2005: Katrina M Miranda; Andrew S Dutton; Lisa A Ridnour; Christian A Foreman; Eleonora Ford; Nazareno Paolocci; Tatsuo Katori; Carlo G Tocchetti; Daniele Mancardi; Douglas D Thomas; Michael G Espey; Kendall N Houk; Jon M Fukuto; David A Wink
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
Journal of the American Chemical Society 2005;127(2):722-31.
2005: Katrina M Miranda; Herbert T Nagasawa; John P Toscano
Donors of HNO.
Current topics in medicinal chemistry 2005;5(7):649-64.
2005: Jon M Fukuto; Christopher H Switzer; Katrina M Miranda; David A Wink
Nitroxyl (HNO): chemistry, biochemistry, and pharmacology.
Annual review of pharmacology and toxicology 2005;45():335-55.
2004: Daniele Mancardi; Lisa A Ridnour; Douglas D Thomas; Tatsuo Katori; Carlo G Tocchetti; Michael G Espey; Katrina M Miranda; Nazareno Paolocci; David A Wink
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.
Current molecular medicine 2004;4(7):723-40.
2004: Lisa A Ridnour; Douglas D Thomas; Daniele Mancardi; Michael G Espey; Katrina M Miranda; Nazareno Paolocci; Martin Feelisch; Jon M Fukuto; David A Wink
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
Biological chemistry 2004;385(1):1-10.
2003: David A Wink; Katrina M Miranda; Tatsuo Katori; Daniele Mancardi; Douglas D Thomas; Lisa A Ridnour; Michael G Espey; Martin Feelisch; Carol A. Colton; Jon M Fukuto; Pasquale Pagliaro; David A Kass; Nazareno Paolocci
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2264-76.
2003: Katrina M Miranda; Nazareno Paolocci; Tatsuo Katori; Douglas D Thomas; Eleonora Ford; Michael D Bartberger; Michael G Espey; David A Kass; Martin Feelisch; Jon M Fukuto; David A Wink
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9196-201.
2003: Douglas D Thomas; Katrina M Miranda; Carol A. Colton; Deborah Citrin; Michael G Espey; David A Wink
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.
Antioxidants & redox signaling 2003;5(3):307-17.
2003: Nazareno Paolocci; Tatsuo Katori; Hunter C Champion; Marcus E St John; Katrina M Miranda; Jon M Fukuto; David A Wink; David A Kass
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5537-42.
2003: Lorne J Hofseth; Shin'ichi Saito; S Perwez Hussain; Michael G Espey; Katrina M Miranda; Yuzuru Araki; Chamelli Jhappan; Yuichiro Higashimoto; Peijun He; Steven P Linke; Martha Quezado; Irit Zurer; Varda Rotter; David A Wink; Ettore Appella; Curtis C Harris
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):143-8.
2003: Katrina M Miranda; Raymond W Nims; Douglas D Thomas; Michael G Espey; Deborah Citrin; Michael D Bartberger; Nazareno Paolocci; Jon M Fukuto; Martin Feelisch; David A Wink
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
Journal of inorganic biochemistry 2003;93(1-2):52-60.
2003: Pasquale Pagliaro; Daniele Mancardi; Raffaella Rastaldo; Claudia Penna; Donatella Gattullo; Katrina M Miranda; Martin Feelisch; David A Wink; David A Kass; Nazareno Paolocci
Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.
Free radical biology & medicine 2003;34(1):33-43.
2002: Douglas D Thomas; Michael G Espey; Michael P. Vitek; Katrina M Miranda; David A Wink
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12691-6.
2002: Michael G Espey; Katrina M Miranda; Douglas D Thomas; David A Wink
Ingress and reactive chemistry of nitroxyl-derived species within human cells.
Free radical biology & medicine 2002;33(6):827-34.
2002: Michael D Bartberger; Wei Liu; Eleonora Ford; Katrina M Miranda; Christopher H Switzer; Jon M Fukuto; Patrick J Farmer; David A Wink; Kendall N Houk
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):10958-63.
2002: Michael G Espey; Douglas D Thomas; Katrina M Miranda; David A Wink
Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11127-32.
2002: Katrina M Miranda; Ken-ichi Yamada; Michael G Espey; Douglas D Thomas; William DeGraff; James B Mitchell; Murali K Cherukuri; Carol A. Colton; David A Wink
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
Archives of biochemistry and biophysics 2002;401(2):134-44.
2002: Michael G Espey; Katrina M Miranda; Douglas D Thomas; Sandhya Xavier; Deborah Citrin; Michael P. Vitek; David A Wink
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.
Annals of the New York Academy of Sciences 2002;962():195-206.
2002: Michael G Espey; Sandhya Xavier; Douglas D Thomas; Katrina M Miranda; David A Wink
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3481-6.
2002: Douglas D Thomas; Katrina M Miranda; Michael G Espey; Deborah Citrin; David Jourd'heuil; Nazareno Paolocci; Sandra J Hewett; Carol A. Colton; Matthew B Grisham; Martin Feelisch; David A Wink
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems.
Methods in enzymology 2002;359():84-105.
2001: Carol A. Colton; M Gbadegesin; D A Wink; Katrina M Miranda; Michael G Espey; Stefano Vicini
Nitroxyl anion regulation of the NMDA receptor.
Journal of neurochemistry 2001;78(5):1126-34.
2001: Nazareno Paolocci; Walter F Saavedra; Katrina M Miranda; C Martignani; Takayoshi Isoda; Joshua M Hare; Michael G Espey; Jon M Fukuto; Martin Feelisch; David A Wink; David A Kass
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10463-8.
2001: Michael G Espey; Katrina M Miranda; Douglas D Thomas; David A Wink
Distinction between nitrosating mechanisms within human cells and aqueous solution.
The Journal of biological chemistry 2001;276(32):30085-91.
2001: David A Wink; Katrina M Miranda; Michael G Espey; Ryszard M Pluta; Sandra J Hewett; Carol A. Colton; Michael P. Vitek; Martin Feelisch; Matthew B Grisham
Mechanisms of the antioxidant effects of nitric oxide.
Antioxidants & redox signaling 2001;3(2):203-13.
2001: Katrina M Miranda; Michael G Espey; Kenichi Yamada; M Krishna; N Ludwick; S Kim; David Jourd'heuil; Matthew B Grisham; Martin Feelisch; Jon M Fukuto; David A Wink
Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion.
The Journal of biological chemistry 2001;276(3):1720-7.
2000: X Zhou; Michael G Espey; J X Chen; Lorne J Hofseth; Katrina M Miranda; S Perwez Hussain; David A Wink; Curtis C Harris
Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase.
The Journal of biological chemistry 2000;275(28):21241-6.
2000: Michael G Espey; Katrina M Miranda; Ryszard M Pluta; David A Wink
Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals.
The Journal of biological chemistry 2000;275(15):11341-7.
2000: Katrina M Miranda; Michael G Espey; David A Wink
A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity.
Journal of inorganic biochemistry 2000;79(1-4):237-40.
2000: David A Wink; Katrina M Miranda; Michael G Espey
Effects of oxidative and nitrosative stress in cytotoxicity.
Seminars in perinatology 2000;24(1):20-3.
2000: Michael G Espey; Katrina M Miranda; Martin Feelisch; Jon M Fukuto; M B Grisham; Michael P. Vitek; David A Wink
Mechanisms of cell death governed by the balance between nitrosative and oxidative stress.
Annals of the New York Academy of Sciences 2000;899():209-21.