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Harald Mischak

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Dhillon Amardeep S; Yip Yan Yan; Grindlay G Joan; Pakay Julian L; Dangers Marc; Hillmann Meike; Clark William; Pitt Andrew; Mischak Harald; Kolch Walter
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Haubitz Marion; Good David M; Woywodt Alexander; Haller Hermann; Rupprecht Harald; Theodorescu Dan; Dakna Mohammed; Coon Joshua J; Mischak Harald
Identification and validation of urinary biomarkers for differential diagnosis and evaluation of therapeutic intervention in anti-neutrophil cytoplasmic antibody-associated vasculitis.
Mischak Harald; Coon Joshua J; Novak Jan; Weissinger Eva M; Schanstra Joost P; Dominiczak Anna F
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments.

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All Publications

2009: Dhillon Amardeep S; Yip Yan Yan; Grindlay G Joan; Pakay Julian L; Dangers Marc; Hillmann Meike; Clark William; Pitt Andrew; Mischak Harald; Kolch Walter
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Cellular signalling 2009;21(11):1645-51.
2009: Haubitz Marion; Good David M; Woywodt Alexander; Haller Hermann; Rupprecht Harald; Theodorescu Dan; Dakna Mohammed; Coon Joshua J; Mischak Harald
Identification and validation of urinary biomarkers for differential diagnosis and evaluation of therapeutic intervention in anti-neutrophil cytoplasmic antibody-associated vasculitis.
Molecular & cellular proteomics : MCP 2009;8(10):2296-307.
2009: Mischak Harald; Coon Joshua J; Novak Jan; Weissinger Eva M; Schanstra Joost P; Dominiczak Anna F
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments.
Mass spectrometry reviews 2009;28(5):703-24.
2009: Schiffer Eric; Vlahou Antonia; Petrolekas Andreas; Stravodimos Konstantinos; Tauber Robert; Geschwend Jürgen E; Neuhaus Jochen; Stolzenburg Jens-Uwe; Conaway Mark R; Mischak Harald; Theodorescu Dan
Prediction of muscle-invasive bladder cancer using urinary proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4935-43.
2009: Jankowski Vera; van der Giet Markus; Mischak Harald; Morgan Michael; Zidek Walter; Jankowski Joachim
Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.
British journal of pharmacology 2009;157(7):1142-53.
2009: Mischak Harald; Massy Ziad A; Jankowski Joachim
Proteomics in uremia and renal disease.
Seminars in dialysis 2009;22(4):409-16.
2009: Vanholder Raymond; Abou-Deif Omar; Argiles Angel; Baurmeister Ulrich; Beige Joachim; Brouckaert Peter; Brunet Philippe; Cohen Gerald; De Deyn Peter Paul; Drüeke Tilman B; Fliser Danilo; Glorieux Griet; Herget-Rosenthal Stefan; Hörl Walter H; Jankowski Joachim; Jörres Achim; Massy Ziad A; Mischak Harald; Perna Alessandra F; Rodriguez-Portillo Juan Mariano; Spasovski Goce; Stegmayr Bernd G; Stenvinkel Peter; Thornalley Paul J; Wanner Christoph; Wiecek Andrzej
The role of EUTox in uremic toxin research.
Seminars in dialysis 2009;22(4):323-8.
2009: Kistler Andreas D; Mischak Harald; Poster Diane; Dakna Mohammed; Wüthrich Rudolf P; Serra Andreas L
Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease.
Kidney international 2009;76(1):89-96.
2009: Drube Jens; Schiffer Eric; Mischak Harald; Kemper Markus J; Neuhaus Thomas; Pape Lars; Lichtinghagen Ralf; Ehrich Jochen H H
Urinary proteome pattern in children with renal Fanconi syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(7):2161-9.
2009: Dakna Mohammed; He Zengyou; Yu Wei Chuan; Mischak Harald; Kolch Walter
Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: a critical assessment.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1250-8.
2009: Zürbig Petra; Decramer Stéphane; Dakna Mohammed; Jantos Justyna; Good David M; Coon Joshua J; Bandin Flavio; Mischak Harald; Bascands Jean-Loup; Schanstra Joost P
The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease.
Proteomics 2009;9(8):2108-17.
2009: Metzger Jochen; Schanstra Joost P; Mischak Harald
Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments.
Analytical and bioanalytical chemistry 2009;393(5):1431-42.
2009: Snell-Bergeon Janet K; Maahs David M; Ogden Lorraine G; Kinney Gregory L; Hokanson John E; Schiffer Eric; Rewers Marian; Mischak Harald
Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease.
Diabetes technology & therapeutics 2009;11(1):1-9.
2009: von Zur Muhlen Constantin; Schiffer Eric; Zuerbig Petra; Kellmann Marcus; Brasse Mario; Meert Natalie; Vanholder Raymond C; Dominiczak Anna F; Chen Yung Chih; Mischak Harald; Bode Christoph; Peter Karlheinz
Evaluation of urine proteome pattern analysis for its potential to reflect coronary artery atherosclerosis in symptomatic patients.
Journal of proteome research 2009;8(1):335-45.
2009: Jantos-Siwy Justyna; Schiffer Eric; Brand Korbinian; Schumann Gerhard; Rossing Kasper; Delles Christian; Mischak Harald; Metzger Jochen
Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease.
Journal of proteome research 2009;8(1):268-81.
2009: Zürbig Petra; Schiffer Eric; Mischak Harald
Capillary electrophoresis coupled to mass spectrometry for proteomic profiling of human urine and biomarker discovery.
Methods in molecular biology (Clifton, N.J.) 2009;564():105-21.
2009: Metzger Jochen; Luppa Peter B; Good David M; Mischak Harald
Adapting mass spectrometry-based platforms for clinical proteomics applications: The capillary electrophoresis coupled mass spectrometry paradigm.
Critical reviews in clinical laboratory sciences 2009;46(3):129-52.
2009: Schiffer E; Mischak H; Zimmerli L U
Proteomics in gerontology: current applications and future aspects--a mini-review.
Gerontology 2009;55(2):123-37.
2008: Decramer Stéphane; Gonzalez de Peredo Anne; Breuil Benjamin; Mischak Harald; Monsarrat Bernard; Bascands Jean-Loup; Schanstra Joost P
Urine in clinical proteomics.
Molecular & cellular proteomics : MCP 2008;7(10):1850-62.
2008: Vlahou Antonia; Schanstra Joost; Frokiaer Jorgen; El Nahas Meguid; Spasovski Goce; Mischak Harald; Domon Bruno; Allmaier Guenter; Bongcam-Rudloff Erik; Attwood Teresa;
Establishment of a European Network for Urine and Kidney Proteomics.
Journal of proteomics 2008;71(4):490-2.
2008: Jiang Hong; Schiffer Eric; Song Zhangfa; Wang Jianwei; Zürbig Petra; Thedieck Kathrin; Moes Suzette; Bantel Heike; Saal Nadja; Jantos Justyna; Brecht Meiken; Jenö Paul; Hall Michael N; Hager Klaus; Manns Michael P; Hecker Hartmut; Ganser Arnold; Döhner Konstanze; Bartke Andrzej; Meissner Christoph; Mischak Harald; Ju Zhenyu; Rudolph K Lenhard
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11299-304.
2008: Rossing Kasper; Mischak Harald; Dakna Mohammed; Zürbig Petra; Novak Jan; Julian Bruce A; Good David M; Coon Joshua J; Tarnow Lise; Rossing Peter;
Urinary proteomics in diabetes and CKD.
Journal of the American Society of Nephrology : JASN 2008;19(7):1283-90.
2008: Raedler Thomas J; Wittke Stefan; Jahn Holger; Koessler Andreas; Mischak Harald; Wiedemann Klaus
Capillary electrophoresis mass spectrometry as a potential tool to detect lithium-induced nephropathy: Preliminary results.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(3):673-8.
2008: Schiffer Eric; Mischak Harald; Theodorescu Dan; Vlahou Antonia
Challenges of using mass spectrometry as a bladder cancer biomarker discovery platform.
World journal of urology 2008;26(1):67-74.
2008: Zimmerli Lukas U; Schiffer Eric; Zürbig Petra; Good David M; Kellmann Markus; Mouls Laetitia; Pitt Andrew R; Coon Joshua J; Schmieder Roland E; Peter Karlheinz H; Mischak Harald; Kolch Walter; Delles Christian; Dominiczak Anna F
Urinary proteomic biomarkers in coronary artery disease.
Molecular & cellular proteomics : MCP 2008;7(2):290-8.
2008: Schiffer Eric; Mischak Harald; Vanholder Raymond C
Exploring the uremic toxins using proteomic technologies.
Contributions to nephrology 2008;160():159-71.
2008: Decramer Stephane; Z Uuml Rbig Petra; Wittke Stefan; Mischak Harald; Bascands Jean-Loup; Schanstra Joost P
Identification of urinary biomarkers by proteomics in newborns: use in obstructive nephropathy.
Contributions to nephrology 2008;160():127-41.
2008: Zürbig Petra; Mischak Harald
Capillary electrophoresis coupled to mass spectrometry for biomarker discovery and diagnosis of kidney diseases.
Contributions to nephrology 2008;160():107-26.
2007: Julian Bruce A; Wittke Stefan; Novak Jan; Good David M; Coon Joshua J; Kellmann Markus; Zürbig Petra; Schiffer Eric; Haubitz Marion; Moldoveanu Zina; Calcatera Shannon M; Wyatt Robert J; Sýkora Josef; Sládková Eva; Hes Ondrej; Mischak Harald; McGuire Brendan M
Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases.
Electrophoresis 2007;28(23):4469-83.
2007: Good David M; Thongboonkerd Visith; Novak Jan; Bascands Jean-Loup; Schanstra Joost P; Coon Joshua J; Dominiczak Anna; Mischak Harald
Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.
Journal of proteome research 2007;6(12):4549-55.
2007: Vanholder Raymond; Meert Nathalie; Schepers Eva; Glorieux Griet; Argiles Angel; Brunet Philippe; Cohen Gerald; Drüeke Tilman; Mischak Harald; Spasovski Goce; Massy Ziad; Jankowski Joachim;
Review on uraemic solutes II--variability in reported concentrations: causes and consequences.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(11):3115-21.
2007: Theodorescu Dan; Mischak Harald
Mass spectrometry based proteomics in urine biomarker discovery.
World journal of urology 2007;25(5):435-43.
2007: Sniehotta Maike; Schiffer Eric; Zürbig Petra; Novak Jan; Mischak Harald
CE - a multifunctional application for clinical diagnosis.
Electrophoresis 2007;28(9):1407-17.
2007: Fliser Danilo; Novak Jan; Thongboonkerd Visith; Argilés Angel; Jankowski Vera; Girolami Mark A; Jankowski Joachim; Mischak Harald
Advances in urinary proteome analysis and biomarker discovery.
Journal of the American Society of Nephrology : JASN 2007;18(4):1057-71.
2007: Weissinger Eva M; Mischak Harald
Application of proteomics to posttransplantational follow-up.
Methods in molecular medicine 2007;134():217-28.
2006: Schiffer Eric; Mischak Harald; Novak Jan
High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS.
Proteomics 2006;6(20):5615-27.
2006: Zürbig Petra; Renfrow Matthew B; Schiffer Eric; Novak Jan; Walden Michael; Wittke Stefan; Just Ingo; Pelzing Matthias; Neusüss Christian; Theodorescu Dan; Root Karen E; Ross Mark M; Mischak Harald
Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation.
Electrophoresis 2006;27(11):2111-25.
2006: Decramer Stephane; Wittke Stefan; Mischak Harald; Zürbig Petra; Walden Michael; Bouissou François; Bascands Jean-Loup; Schanstra Joost P
Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis.
Nature medicine 2006;12(4):398-400.
2006: Weissinger Eva M; Mischak Harald; Ganser Arnold; Hertenstein Bernd
Value of proteomics applied to the follow-up in stem cell transplantation.
Annals of hematology 2006;85(4):205-11.
2006: Theodorescu Dan; Wittke Stefan; Ross Mark M; Walden Michael; Conaway Mark; Just Ingo; Mischak Harald; Frierson Henry F
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.
The lancet oncology 2006;7(3):230-40.
2006: Weissinger Eva M; Nguyen-Khoa Thao; Fumeron Christine; Saltiel Claudine; Walden Michael; Kaiser Thorsten; Mischak Harald; Drüeke Tilman B; Lacour Bernard; Massy Ziad A
Effects of oral vitamin C supplementation in hemodialysis patients: a proteomic assessment.
Proteomics 2006;6(3):993-1000.
2005: Chalmers Michael J; Mackay Colin Logan; Hendrickson Christopher L; Wittke Stefan; Walden Michael; Mischak Harald; Fliser Danilo; Just Ingo; Marshall Alan G
Combined top-down and bottom-up mass spectrometric approach to characterization of biomarkers for renal disease.
Analytical chemistry 2005;77(22):7163-71.
2005: Kolch Walter; Neusüss Christian; Pelzing Matthias; Mischak Harald
Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery.
Mass spectrometry reviews 2005;24(6):959-77.
2005: Weissinger Eva M; Hertenstein Bernd; Mischak Harald; Ganser Arnold
Online coupling of capillary electrophoresis with mass spectrometry for the identification of biomarkers for clinical diagnosis.
Expert review of proteomics 2005;2(5):639-47.
2005: Wittke Stefan; Haubitz Marion; Walden Michael; Rohde Frank; Schwarz Anke; Mengel Michael; Mischak Harald; Haller Hermann; Gwinner Wilfried
Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(10):2479-88.
2005: Meier Matthias; Kaiser Thorsten; Herrmann Alena; Knueppel Stefan; Hillmann Meike; Koester Peer; Danne Thomas; Haller Hermann; Fliser Danilo; Mischak Harald
Identification of urinary protein pattern in type 1 diabetic adolescents with early diabetic nephropathy by a novel combined proteome analysis.
Journal of diabetes and its complications 2005;19(4):223-32.
2005: Theodorescu Dan; Fliser Danilo; Wittke Stefan; Mischak Harald; Krebs Ronald; Walden Michael; Ross Mark; Eltze Elke; Bettendorf Olaf; Wulfing Christian; Semjonow Axel
Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine.
Electrophoresis 2005;26(14):2797-808.
2005: Fliser Danilo; Wittke Stefan; Mischak Harald
Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes.
Electrophoresis 2005;26(14):2708-16.
2005: Rossing Kasper; Mischak Harald; Parving Hans-Henrik; Christensen Per K; Walden Michael; Hillmann Meike; Kaiser Thorsten
Impact of diabetic nephropathy and angiotensin II receptor blockade on urinary polypeptide patterns.
Kidney international 2005;68(1):193-205.
2005: Haubitz Marion; Wittke Stefan; Weissinger Eva M; Walden Michael; Rupprecht Harald D; Floege Jürgen; Haller Hermann; Mischak Harald
Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy.
Kidney international 2005;67(6):2313-20.
2005: Kolch Walter; Mischak Harald; Pitt Andrew R
The molecular make-up of a tumour: proteomics in cancer research.
Clinical science (London, England : 1979) 2005;108(5):369-83.
2005: Wittke Stefan; Mischak Harald; Walden Michael; Kolch Walter; Rädler Thomas; Wiedemann Klaus
Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches.
Electrophoresis 2005;26(7-8):1476-87.
2004: Weissinger Eva M; Kaiser Thorsten; Meert Natalie; De Smet Rita; Walden Michael; Mischak Harald; Vanholder Raymond C
Proteomics: a novel tool to unravel the patho-physiology of uraemia.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(12):3068-77.
2004: Mischak Harald; Kaiser Thorsten; Walden Michael; Hillmann Meike; Wittke Stefan; Herrmann Alena; Knueppel Stefan; Haller Hermann; Fliser Danilo
Proteomic analysis for the assessment of diabetic renal damage in humans.
Clinical science (London, England : 1979) 2004;107(5):485-95.
2004: Canagarajah Bertram; Leskow Federico Coluccio; Ho Jonathan Yew Seng; Mischak Harald; Saidi Layla F; Kazanietz Marcelo G; Hurley James H
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
Cell 2004;119(3):407-18.
2004: Schaefer Michael; Mischak Harald; Schnell Susanne; Griese Anne; Iakubov Roman; Riepenhausen Gabriele; Schöfl Christof
Mechanisms of arginine-vasopressin-induced Ca2+ oscillations in beta-cells (HIT-T15): a role for oscillating protein kinase C.
Endocrinology 2004;145(10):4635-44.
2004: Kaiser Thorsten; Wittke Stefan; Just Ingo; Krebs Ronald; Bartel Sebastian; Fliser Danilo; Mischak Harald; Weissinger Eva M
Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use.
Electrophoresis 2004;25(13):2044-55.
2004: Weissinger E M; Oettrich K; Evans C; Genieser H-G; Schwede F; Dangers M; Dammann E; Kolb H-J; Mischak H; Ganser A; Kolch W
Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy.
British journal of cancer 2004;91(1):186-92.
2004: Kaiser Thorsten; Kamal Haytham; Rank Andreas; Kolb Hans-Jochem; Holler Ernst; Ganser Arnold; Hertenstein Bernd; Mischak Harald; Weissinger Eva Maria
Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation.
Blood 2004;104(2):340-9.
2004: Weissinger Eva M; Wittke Stefan; Kaiser Thorsten; Haller Hermann; Bartel Sebastian; Krebs Ronald; Golovko Igor; Rupprecht Harald D; Haubitz Marion; Hecker Hartmut; Mischak Harald; Fliser Danilo
Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes.
Kidney international 2004;65(6):2426-34.
2004: Chalmers Michael J; Kolch Walter; Emmett Mark R; Marshall Alan G; Mischak Harald
Identification and analysis of phosphopeptides.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(1):111-20.
2004: Wittke Stefan; Kaiser Thorsten; Mischak Harald
Differential polypeptide display: the search for the elusive target.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(1):17-26.
2004: Wang Qiming Jane; Lu Ganwei; Schlapkohl Walter A; Goerke Axel; Larsson Christer; Mischak Harald; Blumberg Peter M; Mushinski J Frederic
The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon.
Molecular cancer research : MCR 2004;2(2):129-40.
2004: Kolch Walter; Mischak Harald; Chalmers Michael J; Pitt Andy; Marshall Alan G
Clinical proteomics: a question of technology.
Rapid communications in mass spectrometry : RCM 2004;18(19):2365-6.
2004: Neuhoff Nils v; Kaiser Thorsten; Wittke Stefan; Krebs Ronald; Pitt Andrew; Burchard Aurea; Sundmacher Astrid; Schlegelberger Brigitte; Kolch Walter; Mischak Harald
Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(2):149-56.
2003: Wittke Stefan; Fliser Danilo; Haubitz Marion; Bartel Sebastian; Krebs Ronald; Hausadel Frank; Hillmann Meike; Golovko Igor; Koester Peer; Haller Hermann; Kaiser Thorsten; Mischak Harald; Weissinger Eva M
Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers.
Journal of chromatography. A 2003;1013(1-2):173-81.
2003: Kaiser Thorsten; Hermann Alena; Kielstein Jan T; Wittke Stefan; Bartel Sebastian; Krebs Ronald; Hausadel Frank; Hillmann Meike; Golovko Igor; Koester Peer; Haller Hermann; Weissinger Eva M; Fliser Danilo; Mischak Harald
Capillary electrophoresis coupled to mass spectrometry to establish polypeptide patterns in dialysis fluids.
Journal of chromatography. A 2003;1013(1-2):157-71.
2003: Brandt Dominique T; Goerke Axel; Heuer Marion; Gimona Mario; Leitges Michael; Kremmer Elisabeth; Lammers Reiner; Haller Hermann; Mischak Harald
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.
The Journal of biological chemistry 2003;278(36):34073-8.
2003: Chalmers Michael J; Quinn John P; Blakney Greg T; Emmett Mark R; Mischak Harold; Gaskell Simon J; Marshall Alan G
Liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometric characterization of protein kinase C phosphorylation.
Journal of proteome research 2003;2(4):373-82.
2003: Eitel Katrin; Staiger Harald; Rieger Johannes; Mischak Harald; Brandhorst Heide; Brendel Mathias D; Bretzel Reinhard G; Häring Hans-Ulrich; Kellerer Monika
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.
Diabetes 2003;52(4):991-7.
2003: Dhillon Amardeep S; Meikle Sharon; Peyssonnaux Carole; Grindlay Joan; Kaiser Christian; Steen Helge; Shaw Peter E; Mischak Harald; Eychène Alain; Kolch Walter
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.
Molecular and cellular biology 2003;23(6):1983-93.
2002: Goerke Axel; Sakai Norio; Gutjahr Elisabeth; Schlapkohl Walter A; Mushinski J Frederic; Haller Hermann; Kolch Walter; Saito Naoaki; Mischak Harald
Induction of apoptosis by protein kinase C delta is independent of its kinase activity.
The Journal of biological chemistry 2002;277(35):32054-62.
2002: Brandt Dominique; Gimona Mario; Hillmann Meike; Haller Hermann; Mischak Harald
Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway.
The Journal of biological chemistry 2002;277(23):20903-10.
2002: Dhillon Amardeep S; Pollock Claire; Steen Helge; Shaw Peter E; Mischak Harald; Kolch Walter
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
Molecular and cellular biology 2002;22(10):3237-46.
2002: Hennige Anita M; Fritsche Andreas; Strack Volker; Weigert Cora; Mischak Harald; Borboni Patricia; Renn Walter; Häring Hans-Ulrich; Kellerer Monika
PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38.
Biochemical and biophysical research communications 2002;290(1):85-90.
2002: Walter Robert; Mischak Harald; Haller Hermann
Haemodialysis, atherosclerosis and inflammation-identifying molecular mechanisms of chronic vascular disease in ESDR patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17 Suppl 3():24-9.
2001: Krasel C; Dammeier S; Winstel R; Brockmann J; Mischak H; Lohse M J
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
The Journal of biological chemistry 2001;276(3):1911-5.
2000: Janosch P; Kieser A; Eulitz M; Lovric J; Sauer G; Reichert M; Gounari F; Büscher D; Baccarini M; Mischak H; Kolch W
The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2008-21.
2000: Dammeier S; Lovric J; Eulitz M; Kolch W; Mushinski J F; Mischak H
Identification of the smooth muscle-specific protein, sm22, as a novel protein kinase C substrate using two-dimensional gel electrophoresis and mass spectrometry.
Electrophoresis 2000;21(12):2443-53.
2000: Abraham D; Podar K; Pacher M; Kubicek M; Welzel N; Hemmings B A; Dilworth S M; Mischak H; Kolch W; Baccarini M
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.
The Journal of biological chemistry 2000;275(29):22300-4.
2000: Yeung K; Janosch P; McFerran B; Rose D W; Mischak H; Sedivy J M; Kolch W
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.
Molecular and cellular biology 2000;20(9):3079-85.
1999: Cooper D R; Watson J E; Patel N; Illingworth P; Acevedo-Duncan M; Goodnight J; Chalfant C E; Mischak H
Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells.
Archives of biochemistry and biophysics 1999;372(1):69-79.
1999: Yeung K; Seitz T; Li S; Janosch P; McFerran B; Kaiser C; Fee F; Katsanakis K D; Rose D W; Mischak H; Sedivy J M; Kolch W
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
Nature 1999;401(6749):173-7.
1998: Lovric J; Dammeier S; Kieser A; Mischak H; Kolch W
Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network.
The Journal of biological chemistry 1998;273(35):22848-55.
1998: Kellerer M; Mushack J; Seffer E; Mischak H; Ullrich A; Häring H U
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).
Diabetologia 1998;41(7):833-8.
1998: Maucher C; Weissinger E M; Kremmer E; Baccarini M; Procyk K; Henderson D W; Wolff L; Kolch W; Kaspers B; Mushinski J F; Mischak H
Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines.
FEBS letters 1998;427(1):29-35.
1998: Prouty S M; Maroo A; Maucher C; Mischak H; Kolch W; Sedivy J M
Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts.
Biochimica et biophysica acta 1998;1402(1):6-16.
1998: Müller G; Storz P; Bourteele S; Döppler H; Pfizenmaier K; Mischak H; Philipp A; Kaiser C; Kolch W
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.
The EMBO journal 1998;17(3):732-42.
1998: Wang Q J; Acs P; Goodnight J; Blumberg P M; Mischak H; Mushinski J F
The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation.
Oncogene 1998;16(1):53-60.
1997: Ueffing M; Lovric J; Philipp A; Mischak H; Kolch W
Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity.
Oncogene 1997;15(24):2921-7.
1997: Kellerer M; Mushack J; Mischak H; Häring H U
Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells.
FEBS letters 1997;418(1-2):119-22.
1997: Weissinger E M; Eissner G; Grammer C; Fackler S; Haefner B; Yoon L S; Lu K S; Bazarov A; Sedivy J M; Mischak H; Kolch W
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.
Molecular and cellular biology 1997;17(6):3229-41.
1997: Wang Q J; Acs P; Goodnight J; Giese T; Blumberg P M; Mischak H; Mushinski J F
The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes.
The Journal of biological chemistry 1997;272(1):76-82.
1996: Mischak H; Seitz T; Janosch P; Eulitz M; Steen H; Schellerer M; Philipp A; Kolch W
Negative regulation of Raf-1 by phosphorylation of serine 621.
Molecular and cellular biology 1996;16(10):5409-18.
1996: Kolch W; Philipp A; Mischak H; Dutil E M; Mullen T M; Feramisco J R; Meinkoth J L; Rose D W
Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding.
Oncogene 1996;13(6):1305-14.
1996: Kieser A; Seitz T; Adler H S; Coffer P; Kremmer E; Crespo P; Gutkind J S; Henderson D W; Mushinski J F; Kolch W; Mischak H
Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.
Genes & development 1996;10(12):1455-66.
1996: Janosch P; Schellerer M; Seitz T; Reim P; Eulitz M; Brielmeier M; Kölch W; Sedivy J M; Mischak H
Characterization of IkappaB kinases. IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate.
The Journal of biological chemistry 1996;271(23):13868-74.
1996: Morawetz R; Lendenfeld T; Mischak H; Mühlbauer M; Gruber F; Goodnight J; de Graaff L H; Visser J; Mushinski J F; Kubicek C P
Cloning and characterisation of genes (pkc1 and pkcA) encoding protein kinase C homologues from Trichoderma reesei and Aspergillus niger.
Molecular & general genetics : MGG 1996;250(1):17-28.
1995: Kieser A; Goodnight J; Kölch W; Mischak H; Mushinski J F
Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes.
FEBS letters 1995;372(2-3):189-93.
1995: Crespo P; Mischak H; Gutkind J S
Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells.
Biochemical and biophysical research communications 1995;213(1):266-72.
1995: Chalfant C E; Mischak H; Watson J E; Winkler B C; Goodnight J; Farese R V; Cooper D R
Regulation of alternative splicing of protein kinase C beta by insulin.
The Journal of biological chemistry 1995;270(22):13326-32.
1995: Goodnight J A; Mischak H; Kolch W; Mushinski J F
Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes.
The Journal of biological chemistry 1995;270(17):9991-10001.
1995: Li S; Janosch P; Tanji M; Rosenfeld G C; Waymire J C; Mischak H; Kolch W; Sedivy J M
Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.
The EMBO journal 1995;14(4):685-96.
1994: Goodnight J; Mischak H; Mushinski J F
Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia.
Molecular carcinogenesis 1994;11(3):131-7.
1994: Eissner G; Kölch W; Mischak H; Bornkamm G W; Holler E
Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro.
Scandinavian journal of immunology 1994;40(4):395-402.
1994: Häfner S; Adler H S; Mischak H; Janosch P; Heidecker G; Wolfman A; Pippig S; Lohse M; Ueffing M; Kolch W
Mechanism of inhibition of Raf-1 by protein kinase A.
Molecular and cellular biology 1994;14(10):6696-703.
1994: Morawetz R; Mischak H; Goodnight J; Lendenfeld T; Mushinsky J F; Kubicek C P
A protein kinase-encoding gene, pkt1, from Trichoderma reesei, homologous to the yeast YPK1 and YPK2 (YKR2) genes.
Gene 1994;146(2):309-10.
1994: Farese R V; Standaert M L; Arnold T P; Yamada K; Musunuru K; Hernandez H; Mischak H; Cooper D R
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes.
The Journal of clinical investigation 1994;93(5):1894-9.
1994: Kazanietz M G; Bustelo X R; Barbacid M; Kolch W; Mischak H; Wong G; Pettit G R; Bruns J D; Blumberg P M
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products.
The Journal of biological chemistry 1994;269(15):11590-4.
1994: Lehel C; Olah Z; Mischak H; Mushinski J F; Anderson W B
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.
The Journal of biological chemistry 1994;269(7):4761-6.
1994: Weissinger E M; Henderson D W; Mischak H; Goodnight J; Mushinski J F
Induction of plasmacytomas that secrete monoclonal anti-peptide antibodies by retroviral transformation.
Journal of immunological methods 1994;168(1):123-30.
1994: Huppi K; Siwarski D; Goodnight J; Mischak H
Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14.
Genomics 1994;19(1):161-2.
1994: Li W; Mischak H; Yu J C; Wang L M; Mushinski J F; Heidaran M A; Pierce J H
Tyrosine phosphorylation of protein kinase C-delta in response to its activation.
The Journal of biological chemistry 1994;269(4):2349-52.
1994: Goodnight J; Mischak H; Mushinski J F
Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation.
Advances in cancer research 1994;64():159-209.
1993: Arnold T P; Standaert M L; Hernandez H; Watson J; Mischak H; Kazanietz M G; Zhao L; Cooper D R; Farese R V
Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes.
The Biochemical journal 1993;295 ( Pt 1)():155-64.
1993: Mischak H; Pierce J H; Goodnight J; Kazanietz M G; Blumberg P M; Mushinski J F
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.
The Journal of biological chemistry 1993;268(27):20110-5.
1993: Kazanietz M G; Areces L B; Bahador A; Mischak H; Goodnight J; Mushinski J F; Blumberg P M
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1993;44(2):298-307.
1993: Mischak H; Goodnight J; Henderson D W; Osada S; Ohno S; Mushinski J F
Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms.
FEBS letters 1993;326(1-3):51-5.
1993: Kolch W; Heidecker G; Kochs G; Hummel R; Vahidi H; Mischak H; Finkenzeller G; Marmé D; Rapp U R
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
Nature 1993;364(6434):249-52.
1993: Martiny-Baron G; Kazanietz M G; Mischak H; Blumberg P M; Kochs G; Hug H; Marmé D; Schächtele C
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
The Journal of biological chemistry 1993;268(13):9194-7.
1993: Weissinger E M; Mischak H; Goodnight J; Davidson W F; Mushinski J F
Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas.
Molecular and cellular biology 1993;13(4):2578-85.
1993: Mischak H; Goodnight J A; Kolch W; Martiny-Baron G; Schaechtle C; Kazanietz M G; Blumberg P M; Pierce J H; Mushinski J F
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.
The Journal of biological chemistry 1993;268(9):6090-6.
1993: Ozawa K; Szallasi Z; Kazanietz M G; Blumberg P M; Mischak H; Mushinski J F; Beaven M A
Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.
The Journal of biological chemistry 1993;268(3):1749-56.
1992: Goodnight J; Kazanietz M G; Blumberg P M; Mushinski J F; Mischak H
The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.
Gene 1992;122(2):305-11.
1992: Dlugosz A A; Mischak H; Mushinski J F; Yuspa S H
Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells.
Molecular carcinogenesis 1992;5(4):286-92.
1991: Mischak H; Kolch W; Goodnight J; Davidson W F; Rapp U; Rose-John S; Mushinski J F
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3981-7.
1991: Weissinger E M; Mischak H; Largaespada D A; Kaehler D A; Mitchell T; Smith-Gill S J; Risser R; Mushinski J F
Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8735-9.
1991: Mischak H; Bodenteich A; Kolch W; Goodnight J; Hofer F; Mushinski J F
Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein.
Biochemistry 1991;30(32):7925-31.
1990: Mischak H; Kolch W; Hofer F; Weissinger E; Gessl A; Davidson W F; Aiello F B; Blaas D; Rapp U R
A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas.
Oncogene 1990;5(9):1377-82.
1990: Kolch W; Weissinger E; Mischak H; Troppmair J; Showalter S D; Lloyd P; Heidecker G; Rapp U R
Probing structure and function of the raf protein kinase domain with monoclonal antibodies.
Oncogene 1990;5(5):713-20.
1990: Largaespada D; Kaehler D; Weissinger E; Mischak H; Mushinski F; Risser R
The activity of an ABL-MYC retrovirus in fibroblast cell lines and in lymphocytes.
Current topics in microbiology and immunology 1990;166():91-6.
1990: Weissinger E M; Largaespada D; Smith-Gill S J; Risser R; Mushinski J F; Mischak H
A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult pristane-primed BALB/c mice.
Current topics in microbiology and immunology 1990;166():121-7.
1989: Mischak H; Hofer F; Messner R; Weissinger E; Hayn M; Tomme P; Esterbauer H; Küchler E; Claeyssens M; Kubicek C P
Monoclonal antibodies against different domains of cellobiohydrolase I and II from Trichoderma reesei.
Biochimica et biophysica acta 1989;990(1):1-7.

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